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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome analysis of the platypus reveals unique signatures of evolution</title><author><name sortKey="Warren, Wesley C" sort="Warren, Wesley C" uniqKey="Warren W" first="Wesley C." last="Warren">Wesley C. Warren</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Hillier, Ladeana W" sort="Hillier, Ladeana W" uniqKey="Hillier L" first="Ladeana W." last="Hillier">Ladeana W. Hillier</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Marshall Graves, Jennifer A" sort="Marshall Graves, Jennifer A" uniqKey="Marshall Graves J" first="Jennifer A." last="Marshall Graves">Jennifer A. Marshall Graves</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Birney, Ewan" sort="Birney, Ewan" uniqKey="Birney E" first="Ewan" last="Birney">Ewan Birney</name><affiliation><nlm:aff id="A3">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Ponting, Chris P" sort="Ponting, Chris P" uniqKey="Ponting C" first="Chris P." last="Ponting">Chris P. Ponting</name><affiliation><nlm:aff id="A4">MRC Functional Genetics Unit, University of Oxford, Department of Human Physiology, Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK.</nlm:aff></affiliation></author><author><name sortKey="Grutzner, Frank" sort="Grutzner, Frank" uniqKey="Grutzner F" first="Frank" last="Grützner">Frank Grützner</name><affiliation><nlm:aff id="A5">Discipline of Genetics, School of Molecular & Biomedical Science, The University of Adelaide, 5005 South Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Belov, Katherine" sort="Belov, Katherine" uniqKey="Belov K" first="Katherine" last="Belov">Katherine Belov</name><affiliation><nlm:aff id="A6">Faculty of Veterinary Science, The University of Sydney, Sydney, New South Wales 2006, Australia.</nlm:aff></affiliation></author><author><name sortKey="Miller, Webb" sort="Miller, Webb" uniqKey="Miller W" first="Webb" last="Miller">Webb Miller</name><affiliation><nlm:aff id="A7">Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.</nlm:aff></affiliation></author><author><name sortKey="Clarke, Laura" sort="Clarke, Laura" uniqKey="Clarke L" first="Laura" last="Clarke">Laura Clarke</name><affiliation><nlm:aff id="A8">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:aff></affiliation></author><author><name sortKey="Chinwalla, Asif T" sort="Chinwalla, Asif T" uniqKey="Chinwalla A" first="Asif T." last="Chinwalla">Asif T. Chinwalla</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Yang, Shiaw Pyng" sort="Yang, Shiaw Pyng" uniqKey="Yang S" first="Shiaw-Pyng" last="Yang">Shiaw-Pyng Yang</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Heger, Andreas" sort="Heger, Andreas" uniqKey="Heger A" first="Andreas" last="Heger">Andreas Heger</name><affiliation><nlm:aff id="A4">MRC Functional Genetics Unit, University of Oxford, Department of Human Physiology, Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK.</nlm:aff></affiliation></author><author><name sortKey="Locke, Devin P" sort="Locke, Devin P" uniqKey="Locke D" first="Devin P." last="Locke">Devin P. Locke</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Miethke, Pat" sort="Miethke, Pat" uniqKey="Miethke P" first="Pat" last="Miethke">Pat Miethke</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Waters, Paul D" sort="Waters, Paul D" uniqKey="Waters P" first="Paul D." last="Waters">Paul D. Waters</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Veyrunes, Frederic" sort="Veyrunes, Frederic" uniqKey="Veyrunes F" first="Frédéric" last="Veyrunes">Frédéric Veyrunes</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Cambridge University, Department of Veterinary Medicine, Madingley Road, Cambridge CB3 0ES, UK.</nlm:aff></affiliation></author><author><name sortKey="Fulton, Lucinda" sort="Fulton, Lucinda" uniqKey="Fulton L" first="Lucinda" last="Fulton">Lucinda Fulton</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Fulton, Bob" sort="Fulton, Bob" uniqKey="Fulton B" first="Bob" last="Fulton">Bob Fulton</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Graves, Tina" sort="Graves, Tina" uniqKey="Graves T" first="Tina" last="Graves">Tina Graves</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Wallis, John" sort="Wallis, John" uniqKey="Wallis J" first="John" last="Wallis">John Wallis</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Puente, Xose S" sort="Puente, Xose S" uniqKey="Puente X" first="Xose S." last="Puente">Xose S. Puente</name><affiliation><nlm:aff id="A10">Instituto Universitario de Oncologia, Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, 33006-Oviedo, Spain.</nlm:aff></affiliation></author><author><name sortKey="L Pez Otin, Carlos" sort="L Pez Otin, Carlos" uniqKey="L Pez Otin C" first="Carlos" last="L Pez-Otín">Carlos L Pez-Otín</name><affiliation><nlm:aff id="A10">Instituto Universitario de Oncologia, Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, 33006-Oviedo, Spain.</nlm:aff></affiliation></author><author><name sortKey="Ord Ez, Gonzalo R" sort="Ord Ez, Gonzalo R" uniqKey="Ord Ez G" first="Gonzalo R." last="Ord Ez">Gonzalo R. Ord Ez</name><affiliation><nlm:aff id="A10">Instituto Universitario de Oncologia, Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, 33006-Oviedo, Spain.</nlm:aff></affiliation></author><author><name sortKey="Eichler, Evan E" sort="Eichler, Evan E" uniqKey="Eichler E" first="Evan E." last="Eichler">Evan E. Eichler</name><affiliation><nlm:aff id="A11">Department of Genome Sciences, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA.</nlm:aff></affiliation></author><author><name sortKey="Chen, Lin" sort="Chen, Lin" uniqKey="Chen L" first="Lin" last="Chen">Lin Chen</name><affiliation><nlm:aff id="A11">Department of Genome Sciences, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA.</nlm:aff></affiliation></author><author><name sortKey="Cheng, Ze" sort="Cheng, Ze" uniqKey="Cheng Z" first="Ze" last="Cheng">Ze Cheng</name><affiliation><nlm:aff id="A11">Department of Genome Sciences, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA.</nlm:aff></affiliation></author><author><name sortKey="Deakin, Janine E" sort="Deakin, Janine E" uniqKey="Deakin J" first="Janine E." last="Deakin">Janine E. Deakin</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Alsop, Amber" sort="Alsop, Amber" uniqKey="Alsop A" first="Amber" last="Alsop">Amber Alsop</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Thompson, Katherine" sort="Thompson, Katherine" uniqKey="Thompson K" first="Katherine" last="Thompson">Katherine Thompson</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Kirby, Patrick" sort="Kirby, Patrick" uniqKey="Kirby P" first="Patrick" last="Kirby">Patrick Kirby</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Papenfuss, Anthony T" sort="Papenfuss, Anthony T" uniqKey="Papenfuss A" first="Anthony T." last="Papenfuss">Anthony T. Papenfuss</name><affiliation><nlm:aff id="A12">The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.</nlm:aff></affiliation></author><author><name sortKey="Wakefield, Matthew J" sort="Wakefield, Matthew J" uniqKey="Wakefield M" first="Matthew J." last="Wakefield">Matthew J. Wakefield</name><affiliation><nlm:aff id="A12">The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.</nlm:aff></affiliation></author><author><name sortKey="Olender, Tsviya" sort="Olender, Tsviya" uniqKey="Olender T" first="Tsviya" last="Olender">Tsviya Olender</name><affiliation><nlm:aff id="A13">Crown Human Genome Center, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.</nlm:aff></affiliation></author><author><name sortKey="Lancet, Doron" sort="Lancet, Doron" uniqKey="Lancet D" first="Doron" last="Lancet">Doron Lancet</name><affiliation><nlm:aff id="A13">Crown Human Genome Center, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.</nlm:aff></affiliation></author><author><name sortKey="Huttley, Gavin A" sort="Huttley, Gavin A" uniqKey="Huttley G" first="Gavin A." last="Huttley">Gavin A. Huttley</name><affiliation><nlm:aff id="A14">John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Smit, Arian F A" sort="Smit, Arian F A" uniqKey="Smit A" first="Arian F. A." last="Smit">Arian F. A. Smit</name><affiliation><nlm:aff id="A15">Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103-8904, USA.</nlm:aff></affiliation></author><author><name sortKey="Pask, Andrew" sort="Pask, Andrew" uniqKey="Pask A" first="Andrew" last="Pask">Andrew Pask</name><affiliation><nlm:aff id="A16">Department of Zoology, The University of Melbourne, Victoria 3010, Australia.</nlm:aff></affiliation></author><author><name sortKey="Temple Smith, Peter" sort="Temple Smith, Peter" uniqKey="Temple Smith P" first="Peter" last="Temple-Smith">Peter Temple-Smith</name><affiliation><nlm:aff id="A16">Department of Zoology, The University of Melbourne, Victoria 3010, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Monash Institute of Medical Research, 27–31 Wright Street, Clayton, Victoria 3168, Australia.</nlm:aff></affiliation></author><author><name sortKey="Batzer, Mark A" sort="Batzer, Mark A" uniqKey="Batzer M" first="Mark A." last="Batzer">Mark A. Batzer</name><affiliation><nlm:aff id="A18">Department of Biological Sciences, Center for Bio-Modular Multi-Scale Systems, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA.</nlm:aff></affiliation></author><author><name sortKey="Walker, Jerilyn A" sort="Walker, Jerilyn A" uniqKey="Walker J" first="Jerilyn A." last="Walker">Jerilyn A. Walker</name><affiliation><nlm:aff id="A18">Department of Biological Sciences, Center for Bio-Modular Multi-Scale Systems, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA.</nlm:aff></affiliation></author><author><name sortKey="Konkel, Miriam K" sort="Konkel, Miriam K" uniqKey="Konkel M" first="Miriam K." last="Konkel">Miriam K. Konkel</name><affiliation><nlm:aff id="A18">Department of Biological Sciences, Center for Bio-Modular Multi-Scale Systems, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA.</nlm:aff></affiliation></author><author><name sortKey="Harris, Robert S" sort="Harris, Robert S" uniqKey="Harris R" first="Robert S." last="Harris">Robert S. Harris</name><affiliation><nlm:aff id="A7">Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.</nlm:aff></affiliation></author><author><name sortKey="Whittington, Camilla M" sort="Whittington, Camilla M" uniqKey="Whittington C" first="Camilla M." last="Whittington">Camilla M. Whittington</name><affiliation><nlm:aff id="A6">Faculty of Veterinary Science, The University of Sydney, Sydney, New South Wales 2006, Australia.</nlm:aff></affiliation></author><author><name sortKey="Wong, Emily S W" sort="Wong, Emily S W" uniqKey="Wong E" first="Emily S. W." last="Wong">Emily S. W. Wong</name><affiliation><nlm:aff id="A6">Faculty of Veterinary Science, The University of Sydney, Sydney, New South Wales 2006, Australia.</nlm:aff></affiliation></author><author><name sortKey="Gemmell, Neil J" sort="Gemmell, Neil J" uniqKey="Gemmell N" first="Neil J." last="Gemmell">Neil J. Gemmell</name><affiliation><nlm:aff id="A19">School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand.</nlm:aff></affiliation></author><author><name sortKey="Buschiazzo, Emmanuel" sort="Buschiazzo, Emmanuel" uniqKey="Buschiazzo E" first="Emmanuel" last="Buschiazzo">Emmanuel Buschiazzo</name><affiliation><nlm:aff id="A19">School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand.</nlm:aff></affiliation></author><author><name sortKey="Vargas Jentzsch, Iris M" sort="Vargas Jentzsch, Iris M" uniqKey="Vargas Jentzsch I" first="Iris M." last="Vargas Jentzsch">Iris M. Vargas Jentzsch</name><affiliation><nlm:aff id="A19">School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand.</nlm:aff></affiliation></author><author><name sortKey="Merkel, Angelika" sort="Merkel, Angelika" uniqKey="Merkel A" first="Angelika" last="Merkel">Angelika Merkel</name><affiliation><nlm:aff id="A19">School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand.</nlm:aff></affiliation></author><author><name sortKey="Schmitz, Juergen" sort="Schmitz, Juergen" uniqKey="Schmitz J" first="Juergen" last="Schmitz">Juergen Schmitz</name><affiliation><nlm:aff id="A20">Institute of Experimental Pathology, University of Muenster, Von-Esmarch-Strasse 56, D-48149 Muenster, Germany.</nlm:aff></affiliation></author><author><name sortKey="Zemann, Anja" sort="Zemann, Anja" uniqKey="Zemann A" first="Anja" last="Zemann">Anja Zemann</name><affiliation><nlm:aff id="A20">Institute of Experimental Pathology, University of Muenster, Von-Esmarch-Strasse 56, D-48149 Muenster, Germany.</nlm:aff></affiliation></author><author><name sortKey="Churakov, Gennady" sort="Churakov, Gennady" uniqKey="Churakov G" first="Gennady" last="Churakov">Gennady Churakov</name><affiliation><nlm:aff id="A20">Institute of Experimental Pathology, University of Muenster, Von-Esmarch-Strasse 56, D-48149 Muenster, Germany.</nlm:aff></affiliation></author><author><name sortKey="Kriegs, Jan Ole" sort="Kriegs, Jan Ole" uniqKey="Kriegs J" first="Jan Ole" last="Kriegs">Jan Ole Kriegs</name><affiliation><nlm:aff id="A20">Institute of Experimental Pathology, University of Muenster, Von-Esmarch-Strasse 56, D-48149 Muenster, Germany.</nlm:aff></affiliation></author><author><name sortKey="Brosius, Juergen" sort="Brosius, Juergen" uniqKey="Brosius J" first="Juergen" last="Brosius">Juergen Brosius</name><affiliation><nlm:aff id="A20">Institute of Experimental Pathology, University of Muenster, Von-Esmarch-Strasse 56, D-48149 Muenster, Germany.</nlm:aff></affiliation></author><author><name sortKey="Murchison, Elizabeth P" sort="Murchison, Elizabeth P" uniqKey="Murchison E" first="Elizabeth P." last="Murchison">Elizabeth P. Murchison</name><affiliation><nlm:aff id="A21">Cold Spring Harbor Laboratory, Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA.</nlm:aff></affiliation></author><author><name sortKey="Sachidanandam, Ravi" sort="Sachidanandam, Ravi" uniqKey="Sachidanandam R" first="Ravi" last="Sachidanandam">Ravi Sachidanandam</name><affiliation><nlm:aff id="A21">Cold Spring Harbor Laboratory, Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA.</nlm:aff></affiliation></author><author><name sortKey="Smith, Carly" sort="Smith, Carly" uniqKey="Smith C" first="Carly" last="Smith">Carly Smith</name><affiliation><nlm:aff id="A21">Cold Spring Harbor Laboratory, Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA.</nlm:aff></affiliation></author><author><name sortKey="Hannon, Gregory J" sort="Hannon, Gregory J" uniqKey="Hannon G" first="Gregory J." last="Hannon">Gregory J. Hannon</name><affiliation><nlm:aff id="A21">Cold Spring Harbor Laboratory, Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA.</nlm:aff></affiliation></author><author><name sortKey="Tsend Ayush, Enkhjargal" sort="Tsend Ayush, Enkhjargal" uniqKey="Tsend Ayush E" first="Enkhjargal" last="Tsend-Ayush">Enkhjargal Tsend-Ayush</name><affiliation><nlm:aff id="A5">Discipline of Genetics, School of Molecular & Biomedical Science, The University of Adelaide, 5005 South Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Mcmillan, Daniel" sort="Mcmillan, Daniel" uniqKey="Mcmillan D" first="Daniel" last="Mcmillan">Daniel Mcmillan</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Attenborough, Rosalind" sort="Attenborough, Rosalind" uniqKey="Attenborough R" first="Rosalind" last="Attenborough">Rosalind Attenborough</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Rens, Willem" sort="Rens, Willem" uniqKey="Rens W" first="Willem" last="Rens">Willem Rens</name><affiliation><nlm:aff id="A9">Cambridge University, Department of Veterinary Medicine, Madingley Road, Cambridge CB3 0ES, UK.</nlm:aff></affiliation></author><author><name sortKey="Ferguson Smith, Malcolm" sort="Ferguson Smith, Malcolm" uniqKey="Ferguson Smith M" first="Malcolm" last="Ferguson-Smith">Malcolm Ferguson-Smith</name><affiliation><nlm:aff id="A9">Cambridge University, Department of Veterinary Medicine, Madingley Road, Cambridge CB3 0ES, UK.</nlm:aff></affiliation></author><author><name sortKey="Lefevre, Christophe M" sort="Lefevre, Christophe M" uniqKey="Lefevre C" first="Christophe M." last="Lefèvre">Christophe M. Lefèvre</name><affiliation><nlm:aff id="A22">Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria 3080, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Victoria 3010, Australia.</nlm:aff></affiliation></author><author><name sortKey="Sharp, Julie A" sort="Sharp, Julie A" uniqKey="Sharp J" first="Julie A." last="Sharp">Julie A. Sharp</name><affiliation><nlm:aff id="A23">CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Victoria 3010, Australia.</nlm:aff></affiliation></author><author><name sortKey="Nicholas, Kevin R" sort="Nicholas, Kevin R" uniqKey="Nicholas K" first="Kevin R." last="Nicholas">Kevin R. Nicholas</name><affiliation><nlm:aff id="A23">CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Victoria 3010, Australia.</nlm:aff></affiliation></author><author><name sortKey="Ray, David A" sort="Ray, David A" uniqKey="Ray D" first="David A." last="Ray">David A. Ray</name><affiliation><nlm:aff id="A24">Department of Biology, West Virginia University, Morgantown, West Virginia 26505, USA.</nlm:aff></affiliation></author><author><name sortKey="Kube, Michael" sort="Kube, Michael" uniqKey="Kube M" first="Michael" last="Kube">Michael Kube</name><affiliation><nlm:aff id="A25">MPI Molecular Genetics, D-14195 Berlin-Dahlem, Ihnestrasse 73, Germany.</nlm:aff></affiliation></author><author><name sortKey="Reinhardt, Richard" sort="Reinhardt, Richard" uniqKey="Reinhardt R" first="Richard" last="Reinhardt">Richard Reinhardt</name><affiliation><nlm:aff id="A25">MPI Molecular Genetics, D-14195 Berlin-Dahlem, Ihnestrasse 73, Germany.</nlm:aff></affiliation></author><author><name sortKey="Pringle, Thomas H" sort="Pringle, Thomas H" uniqKey="Pringle T" first="Thomas H." last="Pringle">Thomas H. Pringle</name><affiliation><nlm:aff id="A26">Sperling Foundation, Eugene, Oregon 97405, USA.</nlm:aff></affiliation></author><author><name sortKey="Taylor, James" sort="Taylor, James" uniqKey="Taylor J" first="James" last="Taylor">James Taylor</name><affiliation><nlm:aff id="A27">Courant Institute, New York University, New York, New York 10012, USA.</nlm:aff></affiliation></author><author><name sortKey="Jones, Russell C" sort="Jones, Russell C" uniqKey="Jones R" first="Russell C." last="Jones">Russell C. Jones</name><affiliation><nlm:aff id="A28">Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, New South Wales 2308, Australia.</nlm:aff></affiliation></author><author><name sortKey="Nixon, Brett" sort="Nixon, Brett" uniqKey="Nixon B" first="Brett" last="Nixon">Brett Nixon</name><affiliation><nlm:aff id="A28">Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, New South Wales 2308, Australia.</nlm:aff></affiliation></author><author><name sortKey="Dacheux, Jean Louis" sort="Dacheux, Jean Louis" uniqKey="Dacheux J" first="Jean-Louis" last="Dacheux">Jean-Louis Dacheux</name><affiliation><nlm:aff id="A29">UMR INRA-CNRS 6073, Physiologie de la Reproduction et des Comportements, Nouzilly 37380, France.</nlm:aff></affiliation></author><author><name sortKey="Niwa, Hitoshi" sort="Niwa, Hitoshi" uniqKey="Niwa H" first="Hitoshi" last="Niwa">Hitoshi Niwa</name><affiliation><nlm:aff id="A30">Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology (CDB), 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 6500047, Japan.</nlm:aff></affiliation></author><author><name sortKey="Sekita, Yoko" sort="Sekita, Yoko" uniqKey="Sekita Y" first="Yoko" last="Sekita">Yoko Sekita</name><affiliation><nlm:aff id="A30">Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology (CDB), 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 6500047, Japan.</nlm:aff></affiliation></author><author><name sortKey="Huang, Xiaoqiu" sort="Huang, Xiaoqiu" uniqKey="Huang X" first="Xiaoqiu" last="Huang">Xiaoqiu Huang</name><affiliation><nlm:aff id="A31">Department of Computer Science, Iowa State University, 226 Atanasoff Hall, Ames, Iowa 50011, USA.</nlm:aff></affiliation></author><author><name sortKey="Stark, Alexander" sort="Stark, Alexander" uniqKey="Stark A" first="Alexander" last="Stark">Alexander Stark</name><affiliation><nlm:aff id="A32">The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02139, USA.</nlm:aff></affiliation></author><author><name sortKey="Kheradpour, Pouya" sort="Kheradpour, Pouya" uniqKey="Kheradpour P" first="Pouya" last="Kheradpour">Pouya Kheradpour</name><affiliation><nlm:aff id="A32">The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02139, USA.</nlm:aff></affiliation></author><author><name sortKey="Kellis, Manolis" sort="Kellis, Manolis" uniqKey="Kellis M" first="Manolis" last="Kellis">Manolis Kellis</name><affiliation><nlm:aff id="A32">The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02139, USA.</nlm:aff></affiliation></author><author><name sortKey="Flicek, Paul" sort="Flicek, Paul" uniqKey="Flicek P" first="Paul" last="Flicek">Paul Flicek</name><affiliation><nlm:aff id="A3">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Chen, Yuan" sort="Chen, Yuan" uniqKey="Chen Y" first="Yuan" last="Chen">Yuan Chen</name><affiliation><nlm:aff id="A3">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Webber, Caleb" sort="Webber, Caleb" uniqKey="Webber C" first="Caleb" last="Webber">Caleb Webber</name><affiliation><nlm:aff id="A4">MRC Functional Genetics Unit, University of Oxford, Department of Human Physiology, Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK.</nlm:aff></affiliation></author><author><name sortKey="Hardison, Ross" sort="Hardison, Ross" uniqKey="Hardison R" first="Ross" last="Hardison">Ross Hardison</name><affiliation><nlm:aff id="A7">Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.</nlm:aff></affiliation></author><author><name sortKey="Nelson, Joanne" sort="Nelson, Joanne" uniqKey="Nelson J" first="Joanne" last="Nelson">Joanne Nelson</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Hallsworth Pepin, Kym" sort="Hallsworth Pepin, Kym" uniqKey="Hallsworth Pepin K" first="Kym" last="Hallsworth-Pepin">Kym Hallsworth-Pepin</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Delehaunty, Kim" sort="Delehaunty, Kim" uniqKey="Delehaunty K" first="Kim" last="Delehaunty">Kim Delehaunty</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Markovic, Chris" sort="Markovic, Chris" uniqKey="Markovic C" first="Chris" last="Markovic">Chris Markovic</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Minx, Pat" sort="Minx, Pat" uniqKey="Minx P" first="Pat" last="Minx">Pat Minx</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Feng, Yucheng" sort="Feng, Yucheng" uniqKey="Feng Y" first="Yucheng" last="Feng">Yucheng Feng</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Kremitzki, Colin" sort="Kremitzki, Colin" uniqKey="Kremitzki C" first="Colin" last="Kremitzki">Colin Kremitzki</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Mitreva, Makedonka" sort="Mitreva, Makedonka" uniqKey="Mitreva M" first="Makedonka" last="Mitreva">Makedonka Mitreva</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Glasscock, Jarret" sort="Glasscock, Jarret" uniqKey="Glasscock J" first="Jarret" last="Glasscock">Jarret Glasscock</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Wylie, Todd" sort="Wylie, Todd" uniqKey="Wylie T" first="Todd" last="Wylie">Todd Wylie</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Wohldmann, Patricia" sort="Wohldmann, Patricia" uniqKey="Wohldmann P" first="Patricia" last="Wohldmann">Patricia Wohldmann</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Thiru, Prathapan" sort="Thiru, Prathapan" uniqKey="Thiru P" first="Prathapan" last="Thiru">Prathapan Thiru</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Nhan, Michael N" sort="Nhan, Michael N" uniqKey="Nhan M" first="Michael N." last="Nhan">Michael N. Nhan</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Pohl, Craig S" sort="Pohl, Craig S" uniqKey="Pohl C" first="Craig S." last="Pohl">Craig S. Pohl</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Smith, Scott M" sort="Smith, Scott M" uniqKey="Smith S" first="Scott M." last="Smith">Scott M. Smith</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Hou, Shunfeng" sort="Hou, Shunfeng" uniqKey="Hou S" first="Shunfeng" last="Hou">Shunfeng Hou</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Renfree, Marilyn B" sort="Renfree, Marilyn B" uniqKey="Renfree M" first="Marilyn B." last="Renfree">Marilyn B. Renfree</name><affiliation><nlm:aff id="A16">Department of Zoology, The University of Melbourne, Victoria 3010, Australia.</nlm:aff></affiliation></author><author><name sortKey="Mardis, Elaine R" sort="Mardis, Elaine R" uniqKey="Mardis E" first="Elaine R." last="Mardis">Elaine R. Mardis</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Wilson, Richard K" sort="Wilson, Richard K" uniqKey="Wilson R" first="Richard K." last="Wilson">Richard K. Wilson</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18464734</idno><idno type="pmc">2803040</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803040</idno><idno type="RBID">PMC:2803040</idno><idno type="doi">10.1038/nature06936</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">001413</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001413</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome analysis of the platypus reveals unique signatures of evolution</title><author><name sortKey="Warren, Wesley C" sort="Warren, Wesley C" uniqKey="Warren W" first="Wesley C." last="Warren">Wesley C. Warren</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Hillier, Ladeana W" sort="Hillier, Ladeana W" uniqKey="Hillier L" first="Ladeana W." last="Hillier">Ladeana W. Hillier</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Marshall Graves, Jennifer A" sort="Marshall Graves, Jennifer A" uniqKey="Marshall Graves J" first="Jennifer A." last="Marshall Graves">Jennifer A. Marshall Graves</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Birney, Ewan" sort="Birney, Ewan" uniqKey="Birney E" first="Ewan" last="Birney">Ewan Birney</name><affiliation><nlm:aff id="A3">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Ponting, Chris P" sort="Ponting, Chris P" uniqKey="Ponting C" first="Chris P." last="Ponting">Chris P. Ponting</name><affiliation><nlm:aff id="A4">MRC Functional Genetics Unit, University of Oxford, Department of Human Physiology, Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK.</nlm:aff></affiliation></author><author><name sortKey="Grutzner, Frank" sort="Grutzner, Frank" uniqKey="Grutzner F" first="Frank" last="Grützner">Frank Grützner</name><affiliation><nlm:aff id="A5">Discipline of Genetics, School of Molecular & Biomedical Science, The University of Adelaide, 5005 South Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Belov, Katherine" sort="Belov, Katherine" uniqKey="Belov K" first="Katherine" last="Belov">Katherine Belov</name><affiliation><nlm:aff id="A6">Faculty of Veterinary Science, The University of Sydney, Sydney, New South Wales 2006, Australia.</nlm:aff></affiliation></author><author><name sortKey="Miller, Webb" sort="Miller, Webb" uniqKey="Miller W" first="Webb" last="Miller">Webb Miller</name><affiliation><nlm:aff id="A7">Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.</nlm:aff></affiliation></author><author><name sortKey="Clarke, Laura" sort="Clarke, Laura" uniqKey="Clarke L" first="Laura" last="Clarke">Laura Clarke</name><affiliation><nlm:aff id="A8">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:aff></affiliation></author><author><name sortKey="Chinwalla, Asif T" sort="Chinwalla, Asif T" uniqKey="Chinwalla A" first="Asif T." last="Chinwalla">Asif T. Chinwalla</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Yang, Shiaw Pyng" sort="Yang, Shiaw Pyng" uniqKey="Yang S" first="Shiaw-Pyng" last="Yang">Shiaw-Pyng Yang</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Heger, Andreas" sort="Heger, Andreas" uniqKey="Heger A" first="Andreas" last="Heger">Andreas Heger</name><affiliation><nlm:aff id="A4">MRC Functional Genetics Unit, University of Oxford, Department of Human Physiology, Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK.</nlm:aff></affiliation></author><author><name sortKey="Locke, Devin P" sort="Locke, Devin P" uniqKey="Locke D" first="Devin P." last="Locke">Devin P. Locke</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Miethke, Pat" sort="Miethke, Pat" uniqKey="Miethke P" first="Pat" last="Miethke">Pat Miethke</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Waters, Paul D" sort="Waters, Paul D" uniqKey="Waters P" first="Paul D." last="Waters">Paul D. Waters</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Veyrunes, Frederic" sort="Veyrunes, Frederic" uniqKey="Veyrunes F" first="Frédéric" last="Veyrunes">Frédéric Veyrunes</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Cambridge University, Department of Veterinary Medicine, Madingley Road, Cambridge CB3 0ES, UK.</nlm:aff></affiliation></author><author><name sortKey="Fulton, Lucinda" sort="Fulton, Lucinda" uniqKey="Fulton L" first="Lucinda" last="Fulton">Lucinda Fulton</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Fulton, Bob" sort="Fulton, Bob" uniqKey="Fulton B" first="Bob" last="Fulton">Bob Fulton</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Graves, Tina" sort="Graves, Tina" uniqKey="Graves T" first="Tina" last="Graves">Tina Graves</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Wallis, John" sort="Wallis, John" uniqKey="Wallis J" first="John" last="Wallis">John Wallis</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Puente, Xose S" sort="Puente, Xose S" uniqKey="Puente X" first="Xose S." last="Puente">Xose S. Puente</name><affiliation><nlm:aff id="A10">Instituto Universitario de Oncologia, Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, 33006-Oviedo, Spain.</nlm:aff></affiliation></author><author><name sortKey="L Pez Otin, Carlos" sort="L Pez Otin, Carlos" uniqKey="L Pez Otin C" first="Carlos" last="L Pez-Otín">Carlos L Pez-Otín</name><affiliation><nlm:aff id="A10">Instituto Universitario de Oncologia, Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, 33006-Oviedo, Spain.</nlm:aff></affiliation></author><author><name sortKey="Ord Ez, Gonzalo R" sort="Ord Ez, Gonzalo R" uniqKey="Ord Ez G" first="Gonzalo R." last="Ord Ez">Gonzalo R. Ord Ez</name><affiliation><nlm:aff id="A10">Instituto Universitario de Oncologia, Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, 33006-Oviedo, Spain.</nlm:aff></affiliation></author><author><name sortKey="Eichler, Evan E" sort="Eichler, Evan E" uniqKey="Eichler E" first="Evan E." last="Eichler">Evan E. Eichler</name><affiliation><nlm:aff id="A11">Department of Genome Sciences, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA.</nlm:aff></affiliation></author><author><name sortKey="Chen, Lin" sort="Chen, Lin" uniqKey="Chen L" first="Lin" last="Chen">Lin Chen</name><affiliation><nlm:aff id="A11">Department of Genome Sciences, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA.</nlm:aff></affiliation></author><author><name sortKey="Cheng, Ze" sort="Cheng, Ze" uniqKey="Cheng Z" first="Ze" last="Cheng">Ze Cheng</name><affiliation><nlm:aff id="A11">Department of Genome Sciences, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA.</nlm:aff></affiliation></author><author><name sortKey="Deakin, Janine E" sort="Deakin, Janine E" uniqKey="Deakin J" first="Janine E." last="Deakin">Janine E. Deakin</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Alsop, Amber" sort="Alsop, Amber" uniqKey="Alsop A" first="Amber" last="Alsop">Amber Alsop</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Thompson, Katherine" sort="Thompson, Katherine" uniqKey="Thompson K" first="Katherine" last="Thompson">Katherine Thompson</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Kirby, Patrick" sort="Kirby, Patrick" uniqKey="Kirby P" first="Patrick" last="Kirby">Patrick Kirby</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Papenfuss, Anthony T" sort="Papenfuss, Anthony T" uniqKey="Papenfuss A" first="Anthony T." last="Papenfuss">Anthony T. Papenfuss</name><affiliation><nlm:aff id="A12">The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.</nlm:aff></affiliation></author><author><name sortKey="Wakefield, Matthew J" sort="Wakefield, Matthew J" uniqKey="Wakefield M" first="Matthew J." last="Wakefield">Matthew J. Wakefield</name><affiliation><nlm:aff id="A12">The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.</nlm:aff></affiliation></author><author><name sortKey="Olender, Tsviya" sort="Olender, Tsviya" uniqKey="Olender T" first="Tsviya" last="Olender">Tsviya Olender</name><affiliation><nlm:aff id="A13">Crown Human Genome Center, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.</nlm:aff></affiliation></author><author><name sortKey="Lancet, Doron" sort="Lancet, Doron" uniqKey="Lancet D" first="Doron" last="Lancet">Doron Lancet</name><affiliation><nlm:aff id="A13">Crown Human Genome Center, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.</nlm:aff></affiliation></author><author><name sortKey="Huttley, Gavin A" sort="Huttley, Gavin A" uniqKey="Huttley G" first="Gavin A." last="Huttley">Gavin A. Huttley</name><affiliation><nlm:aff id="A14">John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Smit, Arian F A" sort="Smit, Arian F A" uniqKey="Smit A" first="Arian F. A." last="Smit">Arian F. A. Smit</name><affiliation><nlm:aff id="A15">Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103-8904, USA.</nlm:aff></affiliation></author><author><name sortKey="Pask, Andrew" sort="Pask, Andrew" uniqKey="Pask A" first="Andrew" last="Pask">Andrew Pask</name><affiliation><nlm:aff id="A16">Department of Zoology, The University of Melbourne, Victoria 3010, Australia.</nlm:aff></affiliation></author><author><name sortKey="Temple Smith, Peter" sort="Temple Smith, Peter" uniqKey="Temple Smith P" first="Peter" last="Temple-Smith">Peter Temple-Smith</name><affiliation><nlm:aff id="A16">Department of Zoology, The University of Melbourne, Victoria 3010, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Monash Institute of Medical Research, 27–31 Wright Street, Clayton, Victoria 3168, Australia.</nlm:aff></affiliation></author><author><name sortKey="Batzer, Mark A" sort="Batzer, Mark A" uniqKey="Batzer M" first="Mark A." last="Batzer">Mark A. Batzer</name><affiliation><nlm:aff id="A18">Department of Biological Sciences, Center for Bio-Modular Multi-Scale Systems, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA.</nlm:aff></affiliation></author><author><name sortKey="Walker, Jerilyn A" sort="Walker, Jerilyn A" uniqKey="Walker J" first="Jerilyn A." last="Walker">Jerilyn A. Walker</name><affiliation><nlm:aff id="A18">Department of Biological Sciences, Center for Bio-Modular Multi-Scale Systems, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA.</nlm:aff></affiliation></author><author><name sortKey="Konkel, Miriam K" sort="Konkel, Miriam K" uniqKey="Konkel M" first="Miriam K." last="Konkel">Miriam K. Konkel</name><affiliation><nlm:aff id="A18">Department of Biological Sciences, Center for Bio-Modular Multi-Scale Systems, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA.</nlm:aff></affiliation></author><author><name sortKey="Harris, Robert S" sort="Harris, Robert S" uniqKey="Harris R" first="Robert S." last="Harris">Robert S. Harris</name><affiliation><nlm:aff id="A7">Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.</nlm:aff></affiliation></author><author><name sortKey="Whittington, Camilla M" sort="Whittington, Camilla M" uniqKey="Whittington C" first="Camilla M." last="Whittington">Camilla M. Whittington</name><affiliation><nlm:aff id="A6">Faculty of Veterinary Science, The University of Sydney, Sydney, New South Wales 2006, Australia.</nlm:aff></affiliation></author><author><name sortKey="Wong, Emily S W" sort="Wong, Emily S W" uniqKey="Wong E" first="Emily S. W." last="Wong">Emily S. W. Wong</name><affiliation><nlm:aff id="A6">Faculty of Veterinary Science, The University of Sydney, Sydney, New South Wales 2006, Australia.</nlm:aff></affiliation></author><author><name sortKey="Gemmell, Neil J" sort="Gemmell, Neil J" uniqKey="Gemmell N" first="Neil J." last="Gemmell">Neil J. Gemmell</name><affiliation><nlm:aff id="A19">School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand.</nlm:aff></affiliation></author><author><name sortKey="Buschiazzo, Emmanuel" sort="Buschiazzo, Emmanuel" uniqKey="Buschiazzo E" first="Emmanuel" last="Buschiazzo">Emmanuel Buschiazzo</name><affiliation><nlm:aff id="A19">School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand.</nlm:aff></affiliation></author><author><name sortKey="Vargas Jentzsch, Iris M" sort="Vargas Jentzsch, Iris M" uniqKey="Vargas Jentzsch I" first="Iris M." last="Vargas Jentzsch">Iris M. Vargas Jentzsch</name><affiliation><nlm:aff id="A19">School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand.</nlm:aff></affiliation></author><author><name sortKey="Merkel, Angelika" sort="Merkel, Angelika" uniqKey="Merkel A" first="Angelika" last="Merkel">Angelika Merkel</name><affiliation><nlm:aff id="A19">School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand.</nlm:aff></affiliation></author><author><name sortKey="Schmitz, Juergen" sort="Schmitz, Juergen" uniqKey="Schmitz J" first="Juergen" last="Schmitz">Juergen Schmitz</name><affiliation><nlm:aff id="A20">Institute of Experimental Pathology, University of Muenster, Von-Esmarch-Strasse 56, D-48149 Muenster, Germany.</nlm:aff></affiliation></author><author><name sortKey="Zemann, Anja" sort="Zemann, Anja" uniqKey="Zemann A" first="Anja" last="Zemann">Anja Zemann</name><affiliation><nlm:aff id="A20">Institute of Experimental Pathology, University of Muenster, Von-Esmarch-Strasse 56, D-48149 Muenster, Germany.</nlm:aff></affiliation></author><author><name sortKey="Churakov, Gennady" sort="Churakov, Gennady" uniqKey="Churakov G" first="Gennady" last="Churakov">Gennady Churakov</name><affiliation><nlm:aff id="A20">Institute of Experimental Pathology, University of Muenster, Von-Esmarch-Strasse 56, D-48149 Muenster, Germany.</nlm:aff></affiliation></author><author><name sortKey="Kriegs, Jan Ole" sort="Kriegs, Jan Ole" uniqKey="Kriegs J" first="Jan Ole" last="Kriegs">Jan Ole Kriegs</name><affiliation><nlm:aff id="A20">Institute of Experimental Pathology, University of Muenster, Von-Esmarch-Strasse 56, D-48149 Muenster, Germany.</nlm:aff></affiliation></author><author><name sortKey="Brosius, Juergen" sort="Brosius, Juergen" uniqKey="Brosius J" first="Juergen" last="Brosius">Juergen Brosius</name><affiliation><nlm:aff id="A20">Institute of Experimental Pathology, University of Muenster, Von-Esmarch-Strasse 56, D-48149 Muenster, Germany.</nlm:aff></affiliation></author><author><name sortKey="Murchison, Elizabeth P" sort="Murchison, Elizabeth P" uniqKey="Murchison E" first="Elizabeth P." last="Murchison">Elizabeth P. Murchison</name><affiliation><nlm:aff id="A21">Cold Spring Harbor Laboratory, Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA.</nlm:aff></affiliation></author><author><name sortKey="Sachidanandam, Ravi" sort="Sachidanandam, Ravi" uniqKey="Sachidanandam R" first="Ravi" last="Sachidanandam">Ravi Sachidanandam</name><affiliation><nlm:aff id="A21">Cold Spring Harbor Laboratory, Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA.</nlm:aff></affiliation></author><author><name sortKey="Smith, Carly" sort="Smith, Carly" uniqKey="Smith C" first="Carly" last="Smith">Carly Smith</name><affiliation><nlm:aff id="A21">Cold Spring Harbor Laboratory, Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA.</nlm:aff></affiliation></author><author><name sortKey="Hannon, Gregory J" sort="Hannon, Gregory J" uniqKey="Hannon G" first="Gregory J." last="Hannon">Gregory J. Hannon</name><affiliation><nlm:aff id="A21">Cold Spring Harbor Laboratory, Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA.</nlm:aff></affiliation></author><author><name sortKey="Tsend Ayush, Enkhjargal" sort="Tsend Ayush, Enkhjargal" uniqKey="Tsend Ayush E" first="Enkhjargal" last="Tsend-Ayush">Enkhjargal Tsend-Ayush</name><affiliation><nlm:aff id="A5">Discipline of Genetics, School of Molecular & Biomedical Science, The University of Adelaide, 5005 South Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Mcmillan, Daniel" sort="Mcmillan, Daniel" uniqKey="Mcmillan D" first="Daniel" last="Mcmillan">Daniel Mcmillan</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Attenborough, Rosalind" sort="Attenborough, Rosalind" uniqKey="Attenborough R" first="Rosalind" last="Attenborough">Rosalind Attenborough</name><affiliation><nlm:aff id="A2">Australian National University, Canberra, Australian Capital Territory 0200, Australia.</nlm:aff></affiliation></author><author><name sortKey="Rens, Willem" sort="Rens, Willem" uniqKey="Rens W" first="Willem" last="Rens">Willem Rens</name><affiliation><nlm:aff id="A9">Cambridge University, Department of Veterinary Medicine, Madingley Road, Cambridge CB3 0ES, UK.</nlm:aff></affiliation></author><author><name sortKey="Ferguson Smith, Malcolm" sort="Ferguson Smith, Malcolm" uniqKey="Ferguson Smith M" first="Malcolm" last="Ferguson-Smith">Malcolm Ferguson-Smith</name><affiliation><nlm:aff id="A9">Cambridge University, Department of Veterinary Medicine, Madingley Road, Cambridge CB3 0ES, UK.</nlm:aff></affiliation></author><author><name sortKey="Lefevre, Christophe M" sort="Lefevre, Christophe M" uniqKey="Lefevre C" first="Christophe M." last="Lefèvre">Christophe M. Lefèvre</name><affiliation><nlm:aff id="A22">Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria 3080, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Victoria 3010, Australia.</nlm:aff></affiliation></author><author><name sortKey="Sharp, Julie A" sort="Sharp, Julie A" uniqKey="Sharp J" first="Julie A." last="Sharp">Julie A. Sharp</name><affiliation><nlm:aff id="A23">CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Victoria 3010, Australia.</nlm:aff></affiliation></author><author><name sortKey="Nicholas, Kevin R" sort="Nicholas, Kevin R" uniqKey="Nicholas K" first="Kevin R." last="Nicholas">Kevin R. Nicholas</name><affiliation><nlm:aff id="A23">CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Victoria 3010, Australia.</nlm:aff></affiliation></author><author><name sortKey="Ray, David A" sort="Ray, David A" uniqKey="Ray D" first="David A." last="Ray">David A. Ray</name><affiliation><nlm:aff id="A24">Department of Biology, West Virginia University, Morgantown, West Virginia 26505, USA.</nlm:aff></affiliation></author><author><name sortKey="Kube, Michael" sort="Kube, Michael" uniqKey="Kube M" first="Michael" last="Kube">Michael Kube</name><affiliation><nlm:aff id="A25">MPI Molecular Genetics, D-14195 Berlin-Dahlem, Ihnestrasse 73, Germany.</nlm:aff></affiliation></author><author><name sortKey="Reinhardt, Richard" sort="Reinhardt, Richard" uniqKey="Reinhardt R" first="Richard" last="Reinhardt">Richard Reinhardt</name><affiliation><nlm:aff id="A25">MPI Molecular Genetics, D-14195 Berlin-Dahlem, Ihnestrasse 73, Germany.</nlm:aff></affiliation></author><author><name sortKey="Pringle, Thomas H" sort="Pringle, Thomas H" uniqKey="Pringle T" first="Thomas H." last="Pringle">Thomas H. Pringle</name><affiliation><nlm:aff id="A26">Sperling Foundation, Eugene, Oregon 97405, USA.</nlm:aff></affiliation></author><author><name sortKey="Taylor, James" sort="Taylor, James" uniqKey="Taylor J" first="James" last="Taylor">James Taylor</name><affiliation><nlm:aff id="A27">Courant Institute, New York University, New York, New York 10012, USA.</nlm:aff></affiliation></author><author><name sortKey="Jones, Russell C" sort="Jones, Russell C" uniqKey="Jones R" first="Russell C." last="Jones">Russell C. Jones</name><affiliation><nlm:aff id="A28">Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, New South Wales 2308, Australia.</nlm:aff></affiliation></author><author><name sortKey="Nixon, Brett" sort="Nixon, Brett" uniqKey="Nixon B" first="Brett" last="Nixon">Brett Nixon</name><affiliation><nlm:aff id="A28">Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, New South Wales 2308, Australia.</nlm:aff></affiliation></author><author><name sortKey="Dacheux, Jean Louis" sort="Dacheux, Jean Louis" uniqKey="Dacheux J" first="Jean-Louis" last="Dacheux">Jean-Louis Dacheux</name><affiliation><nlm:aff id="A29">UMR INRA-CNRS 6073, Physiologie de la Reproduction et des Comportements, Nouzilly 37380, France.</nlm:aff></affiliation></author><author><name sortKey="Niwa, Hitoshi" sort="Niwa, Hitoshi" uniqKey="Niwa H" first="Hitoshi" last="Niwa">Hitoshi Niwa</name><affiliation><nlm:aff id="A30">Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology (CDB), 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 6500047, Japan.</nlm:aff></affiliation></author><author><name sortKey="Sekita, Yoko" sort="Sekita, Yoko" uniqKey="Sekita Y" first="Yoko" last="Sekita">Yoko Sekita</name><affiliation><nlm:aff id="A30">Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology (CDB), 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 6500047, Japan.</nlm:aff></affiliation></author><author><name sortKey="Huang, Xiaoqiu" sort="Huang, Xiaoqiu" uniqKey="Huang X" first="Xiaoqiu" last="Huang">Xiaoqiu Huang</name><affiliation><nlm:aff id="A31">Department of Computer Science, Iowa State University, 226 Atanasoff Hall, Ames, Iowa 50011, USA.</nlm:aff></affiliation></author><author><name sortKey="Stark, Alexander" sort="Stark, Alexander" uniqKey="Stark A" first="Alexander" last="Stark">Alexander Stark</name><affiliation><nlm:aff id="A32">The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02139, USA.</nlm:aff></affiliation></author><author><name sortKey="Kheradpour, Pouya" sort="Kheradpour, Pouya" uniqKey="Kheradpour P" first="Pouya" last="Kheradpour">Pouya Kheradpour</name><affiliation><nlm:aff id="A32">The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02139, USA.</nlm:aff></affiliation></author><author><name sortKey="Kellis, Manolis" sort="Kellis, Manolis" uniqKey="Kellis M" first="Manolis" last="Kellis">Manolis Kellis</name><affiliation><nlm:aff id="A32">The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02139, USA.</nlm:aff></affiliation></author><author><name sortKey="Flicek, Paul" sort="Flicek, Paul" uniqKey="Flicek P" first="Paul" last="Flicek">Paul Flicek</name><affiliation><nlm:aff id="A3">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Chen, Yuan" sort="Chen, Yuan" uniqKey="Chen Y" first="Yuan" last="Chen">Yuan Chen</name><affiliation><nlm:aff id="A3">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Webber, Caleb" sort="Webber, Caleb" uniqKey="Webber C" first="Caleb" last="Webber">Caleb Webber</name><affiliation><nlm:aff id="A4">MRC Functional Genetics Unit, University of Oxford, Department of Human Physiology, Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK.</nlm:aff></affiliation></author><author><name sortKey="Hardison, Ross" sort="Hardison, Ross" uniqKey="Hardison R" first="Ross" last="Hardison">Ross Hardison</name><affiliation><nlm:aff id="A7">Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.</nlm:aff></affiliation></author><author><name sortKey="Nelson, Joanne" sort="Nelson, Joanne" uniqKey="Nelson J" first="Joanne" last="Nelson">Joanne Nelson</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Hallsworth Pepin, Kym" sort="Hallsworth Pepin, Kym" uniqKey="Hallsworth Pepin K" first="Kym" last="Hallsworth-Pepin">Kym Hallsworth-Pepin</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Delehaunty, Kim" sort="Delehaunty, Kim" uniqKey="Delehaunty K" first="Kim" last="Delehaunty">Kim Delehaunty</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Markovic, Chris" sort="Markovic, Chris" uniqKey="Markovic C" first="Chris" last="Markovic">Chris Markovic</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Minx, Pat" sort="Minx, Pat" uniqKey="Minx P" first="Pat" last="Minx">Pat Minx</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Feng, Yucheng" sort="Feng, Yucheng" uniqKey="Feng Y" first="Yucheng" last="Feng">Yucheng Feng</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Kremitzki, Colin" sort="Kremitzki, Colin" uniqKey="Kremitzki C" first="Colin" last="Kremitzki">Colin Kremitzki</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Mitreva, Makedonka" sort="Mitreva, Makedonka" uniqKey="Mitreva M" first="Makedonka" last="Mitreva">Makedonka Mitreva</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Glasscock, Jarret" sort="Glasscock, Jarret" uniqKey="Glasscock J" first="Jarret" last="Glasscock">Jarret Glasscock</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Wylie, Todd" sort="Wylie, Todd" uniqKey="Wylie T" first="Todd" last="Wylie">Todd Wylie</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Wohldmann, Patricia" sort="Wohldmann, Patricia" uniqKey="Wohldmann P" first="Patricia" last="Wohldmann">Patricia Wohldmann</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Thiru, Prathapan" sort="Thiru, Prathapan" uniqKey="Thiru P" first="Prathapan" last="Thiru">Prathapan Thiru</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Nhan, Michael N" sort="Nhan, Michael N" uniqKey="Nhan M" first="Michael N." last="Nhan">Michael N. Nhan</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Pohl, Craig S" sort="Pohl, Craig S" uniqKey="Pohl C" first="Craig S." last="Pohl">Craig S. Pohl</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Smith, Scott M" sort="Smith, Scott M" uniqKey="Smith S" first="Scott M." last="Smith">Scott M. Smith</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Hou, Shunfeng" sort="Hou, Shunfeng" uniqKey="Hou S" first="Shunfeng" last="Hou">Shunfeng Hou</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Renfree, Marilyn B" sort="Renfree, Marilyn B" uniqKey="Renfree M" first="Marilyn B." last="Renfree">Marilyn B. Renfree</name><affiliation><nlm:aff id="A16">Department of Zoology, The University of Melbourne, Victoria 3010, Australia.</nlm:aff></affiliation></author><author><name sortKey="Mardis, Elaine R" sort="Mardis, Elaine R" uniqKey="Mardis E" first="Elaine R." last="Mardis">Elaine R. Mardis</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author><author><name sortKey="Wilson, Richard K" sort="Wilson, Richard K" uniqKey="Wilson R" first="Richard K." last="Wilson">Richard K. Wilson</name><affiliation><nlm:aff id="A1">Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</nlm:aff></affiliation></author></analytic><series><title level="j">Nature</title><idno type="ISSN">0028-0836</idno><idno type="eISSN">1476-4687</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We present a draft genome sequence of the platypus, <italic>Ornithorhynchus anatinus</italic>. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non-protein-coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0410462</journal-id><journal-id journal-id-type="pubmed-jr-id">6011</journal-id><journal-id journal-id-type="nlm-ta">Nature</journal-id><journal-title>Nature</journal-title><issn pub-type="ppub">0028-0836</issn><issn pub-type="epub">1476-4687</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18464734</article-id><article-id pub-id-type="pmc">2803040</article-id><article-id pub-id-type="doi">10.1038/nature06936</article-id><article-id pub-id-type="manuscript">NIHMS162936</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Genome analysis of the platypus reveals unique signatures of evolution</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Warren</surname><given-names>Wesley C.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib 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contrib-type="author"><name><surname>Renfree</surname><given-names>Marilyn B.</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Mardis</surname><given-names>Elaine R.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>Richard K.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.</aff><aff id="A2"><label>2</label>Australian National University, Canberra, Australian Capital Territory 0200, Australia.</aff><aff id="A3"><label>3</label>EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</aff><aff id="A4"><label>4</label>MRC Functional Genetics Unit, University of Oxford, Department of Human Physiology, Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK.</aff><aff id="A5"><label>5</label>Discipline of Genetics, School of Molecular & Biomedical Science, The University of Adelaide, 5005 South Australia, Australia.</aff><aff id="A6"><label>6</label>Faculty of Veterinary Science, The University of Sydney, Sydney, New South Wales 2006, Australia.</aff><aff id="A7"><label>7</label>Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.</aff><aff id="A8"><label>8</label>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</aff><aff id="A9"><label>9</label>Cambridge University, Department of Veterinary Medicine, Madingley Road, Cambridge CB3 0ES, UK.</aff><aff id="A10"><label>10</label>Instituto Universitario de Oncologia, Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, 33006-Oviedo, Spain.</aff><aff id="A11"><label>11</label>Department of Genome Sciences, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA.</aff><aff id="A12"><label>12</label>The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.</aff><aff id="A13"><label>13</label>Crown Human Genome Center, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.</aff><aff id="A14"><label>14</label>John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 0200, Australia.</aff><aff id="A15"><label>15</label>Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103-8904, USA.</aff><aff id="A16"><label>16</label>Department of Zoology, The University of Melbourne, Victoria 3010, Australia.</aff><aff id="A17"><label>17</label>Monash Institute of Medical Research, 27–31 Wright Street, Clayton, Victoria 3168, Australia.</aff><aff id="A18"><label>18</label>Department of Biological Sciences, Center for Bio-Modular Multi-Scale Systems, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA.</aff><aff id="A19"><label>19</label>School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand.</aff><aff id="A20"><label>20</label>Institute of Experimental Pathology, University of Muenster, Von-Esmarch-Strasse 56, D-48149 Muenster, Germany.</aff><aff id="A21"><label>21</label>Cold Spring Harbor Laboratory, Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA.</aff><aff id="A22"><label>22</label>Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria 3080, Australia.</aff><aff id="A23"><label>23</label>CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Victoria 3010, Australia.</aff><aff id="A24"><label>24</label>Department of Biology, West Virginia University, Morgantown, West Virginia 26505, USA.</aff><aff id="A25"><label>25</label>MPI Molecular Genetics, D-14195 Berlin-Dahlem, Ihnestrasse 73, Germany.</aff><aff id="A26"><label>26</label>Sperling Foundation, Eugene, Oregon 97405, USA.</aff><aff id="A27"><label>27</label>Courant Institute, New York University, New York, New York 10012, USA.</aff><aff id="A28"><label>28</label>Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, New South Wales 2308, Australia.</aff><aff id="A29"><label>29</label>UMR INRA-CNRS 6073, Physiologie de la Reproduction et des Comportements, Nouzilly 37380, France.</aff><aff id="A30"><label>30</label>Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology (CDB), 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 6500047, Japan.</aff><aff id="A31"><label>31</label>Department of Computer Science, Iowa State University, 226 Atanasoff Hall, Ames, Iowa 50011, USA.</aff><aff id="A32"><label>32</label>The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02139, USA.</aff><author-notes><corresp id="CR1">Correspondence and requests for materials should be addressed to W.C.W. (<email>wwarren@wustl.edu</email>) or R.K.W. (<email>rwilson@wustl.edu</email>).</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>12</month><year>2009</year></pub-date><pub-date pub-type="ppub"><day>8</day><month>5</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>7</day><month>1</month><year>2010</year></pub-date><volume>453</volume><issue>7192</issue><fpage>175</fpage><lpage>183</lpage><permissions><copyright-statement>©2008 Nature Publishing Group</copyright-statement><copyright-year>2008</copyright-year></permissions><related-article journal-id-type="nlm-ta" journal-id="Nature" related-article-type="correction-forward" vol="455" page="256" id="N0x1c8f2b0N0x29fdaf0" ext-link-type="pmc"></related-article><abstract><p id="P1">We present a draft genome sequence of the platypus, <italic>Ornithorhynchus anatinus</italic>. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non-protein-coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.</p></abstract><contract-num rid="HG1">R01 HG004037-02
||HG</contract-num><contract-num rid="CA1">P01 CA013106-37
||CA</contract-num><contract-sponsor id="HG1">National Human Genome Research Institute : NHGRI</contract-sponsor><contract-sponsor id="CA1">National Cancer Institute : NCI</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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