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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative Genomics of the Eukaryotes</title><author><name sortKey="Rubin, Gerald M" sort="Rubin, Gerald M" uniqKey="Rubin G" first="Gerald M." last="Rubin">Gerald M. Rubin</name><affiliation><nlm:aff id="A1">Howard Hughes Medical Institute, Berkeley<italic>Drosophila</italic> Genome Project, University of California, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Yandell, Mark D" sort="Yandell, Mark D" uniqKey="Yandell M" first="Mark D." last="Yandell">Mark D. Yandell</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Wortman, Jennifer R" sort="Wortman, Jennifer R" uniqKey="Wortman J" first="Jennifer R." last="Wortman">Jennifer R. Wortman</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Gabor Miklos, George L" sort="Gabor Miklos, George L" uniqKey="Gabor Miklos G" first="George L." last="Gabor Miklos">George L. Gabor Miklos</name><affiliation><nlm:aff id="A4">GenetixXpress, 78 Pacific Road, Palm Beach, Sydney, Australia 2108</nlm:aff></affiliation></author><author><name sortKey="Nelson, Catherine R" sort="Nelson, Catherine R" uniqKey="Nelson C" first="Catherine R." last="Nelson">Catherine R. Nelson</name><affiliation><nlm:aff id="A2">Department of Molecular and Cell Biology, Berkeley<italic>Drosophila</italic> Genome Project, University of California, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Hariharan, Iswar K" sort="Hariharan, Iswar K" uniqKey="Hariharan I" first="Iswar K." last="Hariharan">Iswar K. Hariharan</name><affiliation><nlm:aff id="A5">Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129 USA</nlm:aff></affiliation></author><author><name sortKey="Fortini, Mark E" sort="Fortini, Mark E" uniqKey="Fortini M" first="Mark E." last="Fortini">Mark E. Fortini</name><affiliation><nlm:aff id="A6">Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Peter W" sort="Li, Peter W" uniqKey="Li P" first="Peter W." last="Li">Peter W. Li</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Apweiler, Rolf" sort="Apweiler, Rolf" uniqKey="Apweiler R" first="Rolf" last="Apweiler">Rolf Apweiler</name><affiliation><nlm:aff id="A7">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</nlm:aff></affiliation></author><author><name sortKey="Fleischmann, Wolfgang" sort="Fleischmann, Wolfgang" uniqKey="Fleischmann W" first="Wolfgang" last="Fleischmann">Wolfgang Fleischmann</name><affiliation><nlm:aff id="A7">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</nlm:aff></affiliation></author><author><name sortKey="Cherry, J Michael" sort="Cherry, J Michael" uniqKey="Cherry J" first="J. Michael" last="Cherry">J. Michael Cherry</name><affiliation><nlm:aff id="A8">Department of Genetics, Stanford University, Palo Alto, CA 94305, USA</nlm:aff></affiliation></author><author><name sortKey="Henikoff, Steven" sort="Henikoff, Steven" uniqKey="Henikoff S" first="Steven" last="Henikoff">Steven Henikoff</name><affiliation><nlm:aff id="A9">Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA</nlm:aff></affiliation></author><author><name sortKey="Skupski, Marian P" sort="Skupski, Marian P" uniqKey="Skupski M" first="Marian P." last="Skupski">Marian P. Skupski</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Misra, Sima" sort="Misra, Sima" uniqKey="Misra S" first="Sima" last="Misra">Sima Misra</name><affiliation><nlm:aff id="A2">Department of Molecular and Cell Biology, Berkeley<italic>Drosophila</italic> Genome Project, University of California, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Ashburner, Michael" sort="Ashburner, Michael" uniqKey="Ashburner M" first="Michael" last="Ashburner">Michael Ashburner</name><affiliation><nlm:aff id="A7">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</nlm:aff></affiliation></author><author><name sortKey="Birney, Ewan" sort="Birney, Ewan" uniqKey="Birney E" first="Ewan" last="Birney">Ewan Birney</name><affiliation><nlm:aff id="A7">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</nlm:aff></affiliation></author><author><name sortKey="Boguski, Mark S" sort="Boguski, Mark S" uniqKey="Boguski M" first="Mark S." last="Boguski">Mark S. Boguski</name><affiliation><nlm:aff id="A10">National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA</nlm:aff></affiliation></author><author><name sortKey="Brody, Thomas" sort="Brody, Thomas" uniqKey="Brody T" first="Thomas" last="Brody">Thomas Brody</name><affiliation><nlm:aff id="A11">Neurogenetics Unit, Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Brokstein, Peter" sort="Brokstein, Peter" uniqKey="Brokstein P" first="Peter" last="Brokstein">Peter Brokstein</name><affiliation><nlm:aff id="A2">Department of Molecular and Cell Biology, Berkeley<italic>Drosophila</italic> Genome Project, University of California, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Celniker, Susan E" sort="Celniker, Susan E" uniqKey="Celniker S" first="Susan E." last="Celniker">Susan E. Celniker</name><affiliation><nlm:aff id="A12">Berkeley<italic>Drosophila</italic> Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Chervitz, Stephen A" sort="Chervitz, Stephen A" uniqKey="Chervitz S" first="Stephen A." last="Chervitz">Stephen A. Chervitz</name><affiliation><nlm:aff id="A13">Neomorphic, 2612 Eighth Street, Berkeley, CA 94710, USA</nlm:aff></affiliation></author><author><name sortKey="Coates, David" sort="Coates, David" uniqKey="Coates D" first="David" last="Coates">David Coates</name><affiliation><nlm:aff id="A14">School of Biology, University of Leeds, Leeds LS2 9JT, UK</nlm:aff></affiliation></author><author><name sortKey="Cravchik, Anibal" sort="Cravchik, Anibal" uniqKey="Cravchik A" first="Anibal" last="Cravchik">Anibal Cravchik</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Gabrielian, Andrei" sort="Gabrielian, Andrei" uniqKey="Gabrielian A" first="Andrei" last="Gabrielian">Andrei Gabrielian</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Galle, Richard F" sort="Galle, Richard F" uniqKey="Galle R" first="Richard F." last="Galle">Richard F. Galle</name><affiliation><nlm:aff id="A12">Berkeley<italic>Drosophila</italic> Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Gelbart, William M" sort="Gelbart, William M" uniqKey="Gelbart W" first="William M." last="Gelbart">William M. Gelbart</name><affiliation><nlm:aff id="A15">Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA</nlm:aff></affiliation></author><author><name sortKey="George, Reed A" sort="George, Reed A" uniqKey="George R" first="Reed A." last="George">Reed A. George</name><affiliation><nlm:aff id="A12">Berkeley<italic>Drosophila</italic> Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Goldstein, Lawrence S B" sort="Goldstein, Lawrence S B" uniqKey="Goldstein L" first="Lawrence S. B." last="Goldstein">Lawrence S. B. Goldstein</name><affiliation><nlm:aff id="A16">Departments of Cellular and Molecular Medicine and Pharmacology, Howard Hughes Medical Institute, University of California–San Diego, La Jolla, CA 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Gong, Fangcheng" sort="Gong, Fangcheng" uniqKey="Gong F" first="Fangcheng" last="Gong">Fangcheng Gong</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Guan, Ping" sort="Guan, Ping" uniqKey="Guan P" first="Ping" last="Guan">Ping Guan</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Harris, Nomi L" sort="Harris, Nomi L" uniqKey="Harris N" first="Nomi L." last="Harris">Nomi L. Harris</name><affiliation><nlm:aff id="A12">Berkeley<italic>Drosophila</italic> Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Hay, Bruce A" sort="Hay, Bruce A" uniqKey="Hay B" first="Bruce A." last="Hay">Bruce A. Hay</name><affiliation><nlm:aff id="A17">Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA</nlm:aff></affiliation></author><author><name sortKey="Hoskins, Roger A" sort="Hoskins, Roger A" uniqKey="Hoskins R" first="Roger A." last="Hoskins">Roger A. Hoskins</name><affiliation><nlm:aff id="A12">Berkeley<italic>Drosophila</italic> Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Jiayin" sort="Li, Jiayin" uniqKey="Li J" first="Jiayin" last="Li">Jiayin Li</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Li, Zhenya" sort="Li, Zhenya" uniqKey="Li Z" first="Zhenya" last="Li">Zhenya Li</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Hynes, Richard O" sort="Hynes, Richard O" uniqKey="Hynes R" first="Richard O." last="Hynes">Richard O. Hynes</name><affiliation><nlm:aff id="A18">Howard Hughes Medical Institute, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Jones, S J M" sort="Jones, S J M" uniqKey="Jones S" first="S. J. M." last="Jones">S. J. M. Jones</name><affiliation><nlm:aff id="A19">Genome Sequence Centre, BC Cancer Research Centre, 600 West 10th Avenue, Vancouver, BC, V52 4E6, Canada</nlm:aff></affiliation></author><author><name sortKey="Kuehl, Peter M" sort="Kuehl, Peter M" uniqKey="Kuehl P" first="Peter M." last="Kuehl">Peter M. Kuehl</name><affiliation><nlm:aff id="A20">Molecular and Cell Biology Program, University of Maryland at Baltimore, Baltimore, MD 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Lemaitre, Bruno" sort="Lemaitre, Bruno" uniqKey="Lemaitre B" first="Bruno" last="Lemaitre">Bruno Lemaitre</name><affiliation><nlm:aff id="A21">Centre de Génétique Moléculaire, CNRS, 91198 Gif-sur-Yvette, France</nlm:aff></affiliation></author><author><name sortKey="Littleton, J Troy" sort="Littleton, J Troy" uniqKey="Littleton J" first="J. Troy" last="Littleton">J. Troy Littleton</name><affiliation><nlm:aff id="A22">Center for Learning and Memory, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Morrison, Deborah K" sort="Morrison, Deborah K" uniqKey="Morrison D" first="Deborah K." last="Morrison">Deborah K. Morrison</name><affiliation><nlm:aff id="A23">Regulation of Cell Growth Laboratory, Division of Basic Sciences, National Cancer Institute–Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff></affiliation></author><author><name sortKey="Mungall, Chris" sort="Mungall, Chris" uniqKey="Mungall C" first="Chris" last="Mungall">Chris Mungall</name><affiliation><nlm:aff id="A12">Berkeley<italic>Drosophila</italic> Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="O Farrell, Patrick H" sort="O Farrell, Patrick H" uniqKey="O Farrell P" first="Patrick H." last="O'Farrell">Patrick H. O'Farrell</name><affiliation><nlm:aff id="A24">Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA</nlm:aff></affiliation></author><author><name sortKey="Pickeral, Oxana K" sort="Pickeral, Oxana K" uniqKey="Pickeral O" first="Oxana K." last="Pickeral">Oxana K. Pickeral</name><affiliation><nlm:aff id="A10">National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA</nlm:aff></affiliation></author><author><name sortKey="Shue, Chris" sort="Shue, Chris" uniqKey="Shue C" first="Chris" last="Shue">Chris Shue</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Vosshall, Leslie B" sort="Vosshall, Leslie B" uniqKey="Vosshall L" first="Leslie B." last="Vosshall">Leslie B. Vosshall</name><affiliation><nlm:aff id="A25">Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Jiong" sort="Zhang, Jiong" uniqKey="Zhang J" first="Jiong" last="Zhang">Jiong Zhang</name><affiliation><nlm:aff id="A10">National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, Qi" sort="Zhao, Qi" uniqKey="Zhao Q" first="Qi" last="Zhao">Qi Zhao</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Xiangqun H" sort="Zheng, Xiangqun H" uniqKey="Zheng X" first="Xiangqun H." last="Zheng">Xiangqun H. Zheng</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Zhong, Fei" sort="Zhong, Fei" uniqKey="Zhong F" first="Fei" last="Zhong">Fei Zhong</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Zhong, Wenyan" sort="Zhong, Wenyan" uniqKey="Zhong W" first="Wenyan" last="Zhong">Wenyan Zhong</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Gibbs, Richard" sort="Gibbs, Richard" uniqKey="Gibbs R" first="Richard" last="Gibbs">Richard Gibbs</name><affiliation><nlm:aff id="A26">Baylor College of Medicine Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Venter, J Craig" sort="Venter, J Craig" uniqKey="Venter J" first="J. Craig" last="Venter">J. Craig Venter</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Adams, Mark D" sort="Adams, Mark D" uniqKey="Adams M" first="Mark D." last="Adams">Mark D. Adams</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Lewis, Suzanna" sort="Lewis, Suzanna" uniqKey="Lewis S" first="Suzanna" last="Lewis">Suzanna Lewis</name><affiliation><nlm:aff id="A2">Department of Molecular and Cell Biology, Berkeley<italic>Drosophila</italic> Genome Project, University of California, Berkeley, CA 94720, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">10731134</idno><idno type="pmc">2754258</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754258</idno><idno type="RBID">PMC:2754258</idno><date when="2000">2000</date><idno type="wicri:Area/Pmc/Corpus">001409</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001409</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparative Genomics of the Eukaryotes</title><author><name sortKey="Rubin, Gerald M" sort="Rubin, Gerald M" uniqKey="Rubin G" first="Gerald M." last="Rubin">Gerald M. Rubin</name><affiliation><nlm:aff id="A1">Howard Hughes Medical Institute, Berkeley<italic>Drosophila</italic> Genome Project, University of California, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Yandell, Mark D" sort="Yandell, Mark D" uniqKey="Yandell M" first="Mark D." last="Yandell">Mark D. Yandell</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Wortman, Jennifer R" sort="Wortman, Jennifer R" uniqKey="Wortman J" first="Jennifer R." last="Wortman">Jennifer R. Wortman</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Gabor Miklos, George L" sort="Gabor Miklos, George L" uniqKey="Gabor Miklos G" first="George L." last="Gabor Miklos">George L. Gabor Miklos</name><affiliation><nlm:aff id="A4">GenetixXpress, 78 Pacific Road, Palm Beach, Sydney, Australia 2108</nlm:aff></affiliation></author><author><name sortKey="Nelson, Catherine R" sort="Nelson, Catherine R" uniqKey="Nelson C" first="Catherine R." last="Nelson">Catherine R. Nelson</name><affiliation><nlm:aff id="A2">Department of Molecular and Cell Biology, Berkeley<italic>Drosophila</italic> Genome Project, University of California, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Hariharan, Iswar K" sort="Hariharan, Iswar K" uniqKey="Hariharan I" first="Iswar K." last="Hariharan">Iswar K. Hariharan</name><affiliation><nlm:aff id="A5">Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129 USA</nlm:aff></affiliation></author><author><name sortKey="Fortini, Mark E" sort="Fortini, Mark E" uniqKey="Fortini M" first="Mark E." last="Fortini">Mark E. Fortini</name><affiliation><nlm:aff id="A6">Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Peter W" sort="Li, Peter W" uniqKey="Li P" first="Peter W." last="Li">Peter W. Li</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Apweiler, Rolf" sort="Apweiler, Rolf" uniqKey="Apweiler R" first="Rolf" last="Apweiler">Rolf Apweiler</name><affiliation><nlm:aff id="A7">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</nlm:aff></affiliation></author><author><name sortKey="Fleischmann, Wolfgang" sort="Fleischmann, Wolfgang" uniqKey="Fleischmann W" first="Wolfgang" last="Fleischmann">Wolfgang Fleischmann</name><affiliation><nlm:aff id="A7">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</nlm:aff></affiliation></author><author><name sortKey="Cherry, J Michael" sort="Cherry, J Michael" uniqKey="Cherry J" first="J. Michael" last="Cherry">J. Michael Cherry</name><affiliation><nlm:aff id="A8">Department of Genetics, Stanford University, Palo Alto, CA 94305, USA</nlm:aff></affiliation></author><author><name sortKey="Henikoff, Steven" sort="Henikoff, Steven" uniqKey="Henikoff S" first="Steven" last="Henikoff">Steven Henikoff</name><affiliation><nlm:aff id="A9">Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA</nlm:aff></affiliation></author><author><name sortKey="Skupski, Marian P" sort="Skupski, Marian P" uniqKey="Skupski M" first="Marian P." last="Skupski">Marian P. Skupski</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Misra, Sima" sort="Misra, Sima" uniqKey="Misra S" first="Sima" last="Misra">Sima Misra</name><affiliation><nlm:aff id="A2">Department of Molecular and Cell Biology, Berkeley<italic>Drosophila</italic> Genome Project, University of California, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Ashburner, Michael" sort="Ashburner, Michael" uniqKey="Ashburner M" first="Michael" last="Ashburner">Michael Ashburner</name><affiliation><nlm:aff id="A7">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</nlm:aff></affiliation></author><author><name sortKey="Birney, Ewan" sort="Birney, Ewan" uniqKey="Birney E" first="Ewan" last="Birney">Ewan Birney</name><affiliation><nlm:aff id="A7">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</nlm:aff></affiliation></author><author><name sortKey="Boguski, Mark S" sort="Boguski, Mark S" uniqKey="Boguski M" first="Mark S." last="Boguski">Mark S. Boguski</name><affiliation><nlm:aff id="A10">National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA</nlm:aff></affiliation></author><author><name sortKey="Brody, Thomas" sort="Brody, Thomas" uniqKey="Brody T" first="Thomas" last="Brody">Thomas Brody</name><affiliation><nlm:aff id="A11">Neurogenetics Unit, Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Brokstein, Peter" sort="Brokstein, Peter" uniqKey="Brokstein P" first="Peter" last="Brokstein">Peter Brokstein</name><affiliation><nlm:aff id="A2">Department of Molecular and Cell Biology, Berkeley<italic>Drosophila</italic> Genome Project, University of California, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Celniker, Susan E" sort="Celniker, Susan E" uniqKey="Celniker S" first="Susan E." last="Celniker">Susan E. Celniker</name><affiliation><nlm:aff id="A12">Berkeley<italic>Drosophila</italic> Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Chervitz, Stephen A" sort="Chervitz, Stephen A" uniqKey="Chervitz S" first="Stephen A." last="Chervitz">Stephen A. Chervitz</name><affiliation><nlm:aff id="A13">Neomorphic, 2612 Eighth Street, Berkeley, CA 94710, USA</nlm:aff></affiliation></author><author><name sortKey="Coates, David" sort="Coates, David" uniqKey="Coates D" first="David" last="Coates">David Coates</name><affiliation><nlm:aff id="A14">School of Biology, University of Leeds, Leeds LS2 9JT, UK</nlm:aff></affiliation></author><author><name sortKey="Cravchik, Anibal" sort="Cravchik, Anibal" uniqKey="Cravchik A" first="Anibal" last="Cravchik">Anibal Cravchik</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Gabrielian, Andrei" sort="Gabrielian, Andrei" uniqKey="Gabrielian A" first="Andrei" last="Gabrielian">Andrei Gabrielian</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Galle, Richard F" sort="Galle, Richard F" uniqKey="Galle R" first="Richard F." last="Galle">Richard F. Galle</name><affiliation><nlm:aff id="A12">Berkeley<italic>Drosophila</italic> Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Gelbart, William M" sort="Gelbart, William M" uniqKey="Gelbart W" first="William M." last="Gelbart">William M. Gelbart</name><affiliation><nlm:aff id="A15">Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA</nlm:aff></affiliation></author><author><name sortKey="George, Reed A" sort="George, Reed A" uniqKey="George R" first="Reed A." last="George">Reed A. George</name><affiliation><nlm:aff id="A12">Berkeley<italic>Drosophila</italic> Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Goldstein, Lawrence S B" sort="Goldstein, Lawrence S B" uniqKey="Goldstein L" first="Lawrence S. B." last="Goldstein">Lawrence S. B. Goldstein</name><affiliation><nlm:aff id="A16">Departments of Cellular and Molecular Medicine and Pharmacology, Howard Hughes Medical Institute, University of California–San Diego, La Jolla, CA 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Gong, Fangcheng" sort="Gong, Fangcheng" uniqKey="Gong F" first="Fangcheng" last="Gong">Fangcheng Gong</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Guan, Ping" sort="Guan, Ping" uniqKey="Guan P" first="Ping" last="Guan">Ping Guan</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Harris, Nomi L" sort="Harris, Nomi L" uniqKey="Harris N" first="Nomi L." last="Harris">Nomi L. Harris</name><affiliation><nlm:aff id="A12">Berkeley<italic>Drosophila</italic> Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Hay, Bruce A" sort="Hay, Bruce A" uniqKey="Hay B" first="Bruce A." last="Hay">Bruce A. Hay</name><affiliation><nlm:aff id="A17">Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA</nlm:aff></affiliation></author><author><name sortKey="Hoskins, Roger A" sort="Hoskins, Roger A" uniqKey="Hoskins R" first="Roger A." last="Hoskins">Roger A. Hoskins</name><affiliation><nlm:aff id="A12">Berkeley<italic>Drosophila</italic> Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Jiayin" sort="Li, Jiayin" uniqKey="Li J" first="Jiayin" last="Li">Jiayin Li</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Li, Zhenya" sort="Li, Zhenya" uniqKey="Li Z" first="Zhenya" last="Li">Zhenya Li</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Hynes, Richard O" sort="Hynes, Richard O" uniqKey="Hynes R" first="Richard O." last="Hynes">Richard O. Hynes</name><affiliation><nlm:aff id="A18">Howard Hughes Medical Institute, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Jones, S J M" sort="Jones, S J M" uniqKey="Jones S" first="S. J. M." last="Jones">S. J. M. Jones</name><affiliation><nlm:aff id="A19">Genome Sequence Centre, BC Cancer Research Centre, 600 West 10th Avenue, Vancouver, BC, V52 4E6, Canada</nlm:aff></affiliation></author><author><name sortKey="Kuehl, Peter M" sort="Kuehl, Peter M" uniqKey="Kuehl P" first="Peter M." last="Kuehl">Peter M. Kuehl</name><affiliation><nlm:aff id="A20">Molecular and Cell Biology Program, University of Maryland at Baltimore, Baltimore, MD 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Lemaitre, Bruno" sort="Lemaitre, Bruno" uniqKey="Lemaitre B" first="Bruno" last="Lemaitre">Bruno Lemaitre</name><affiliation><nlm:aff id="A21">Centre de Génétique Moléculaire, CNRS, 91198 Gif-sur-Yvette, France</nlm:aff></affiliation></author><author><name sortKey="Littleton, J Troy" sort="Littleton, J Troy" uniqKey="Littleton J" first="J. Troy" last="Littleton">J. Troy Littleton</name><affiliation><nlm:aff id="A22">Center for Learning and Memory, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Morrison, Deborah K" sort="Morrison, Deborah K" uniqKey="Morrison D" first="Deborah K." last="Morrison">Deborah K. Morrison</name><affiliation><nlm:aff id="A23">Regulation of Cell Growth Laboratory, Division of Basic Sciences, National Cancer Institute–Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff></affiliation></author><author><name sortKey="Mungall, Chris" sort="Mungall, Chris" uniqKey="Mungall C" first="Chris" last="Mungall">Chris Mungall</name><affiliation><nlm:aff id="A12">Berkeley<italic>Drosophila</italic> Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA</nlm:aff></affiliation></author><author><name sortKey="O Farrell, Patrick H" sort="O Farrell, Patrick H" uniqKey="O Farrell P" first="Patrick H." last="O'Farrell">Patrick H. O'Farrell</name><affiliation><nlm:aff id="A24">Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA</nlm:aff></affiliation></author><author><name sortKey="Pickeral, Oxana K" sort="Pickeral, Oxana K" uniqKey="Pickeral O" first="Oxana K." last="Pickeral">Oxana K. Pickeral</name><affiliation><nlm:aff id="A10">National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA</nlm:aff></affiliation></author><author><name sortKey="Shue, Chris" sort="Shue, Chris" uniqKey="Shue C" first="Chris" last="Shue">Chris Shue</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Vosshall, Leslie B" sort="Vosshall, Leslie B" uniqKey="Vosshall L" first="Leslie B." last="Vosshall">Leslie B. Vosshall</name><affiliation><nlm:aff id="A25">Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Jiong" sort="Zhang, Jiong" uniqKey="Zhang J" first="Jiong" last="Zhang">Jiong Zhang</name><affiliation><nlm:aff id="A10">National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, Qi" sort="Zhao, Qi" uniqKey="Zhao Q" first="Qi" last="Zhao">Qi Zhao</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Xiangqun H" sort="Zheng, Xiangqun H" uniqKey="Zheng X" first="Xiangqun H." last="Zheng">Xiangqun H. Zheng</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Zhong, Fei" sort="Zhong, Fei" uniqKey="Zhong F" first="Fei" last="Zhong">Fei Zhong</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Zhong, Wenyan" sort="Zhong, Wenyan" uniqKey="Zhong W" first="Wenyan" last="Zhong">Wenyan Zhong</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Gibbs, Richard" sort="Gibbs, Richard" uniqKey="Gibbs R" first="Richard" last="Gibbs">Richard Gibbs</name><affiliation><nlm:aff id="A26">Baylor College of Medicine Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Venter, J Craig" sort="Venter, J Craig" uniqKey="Venter J" first="J. Craig" last="Venter">J. Craig Venter</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Adams, Mark D" sort="Adams, Mark D" uniqKey="Adams M" first="Mark D." last="Adams">Mark D. Adams</name><affiliation><nlm:aff id="A3">Celera Genomics, Rockville, MD, 20850 USA</nlm:aff></affiliation></author><author><name sortKey="Lewis, Suzanna" sort="Lewis, Suzanna" uniqKey="Lewis S" first="Suzanna" last="Lewis">Suzanna Lewis</name><affiliation><nlm:aff id="A2">Department of Molecular and Cell Biology, Berkeley<italic>Drosophila</italic> Genome Project, University of California, Berkeley, CA 94720, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="ISSN">0036-8075</idno><idno type="eISSN">1095-9203</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">A comparative analysis of the genomes of <italic>Drosophila melanogaster</italic>, <italic>Caenorhabditis elegans</italic>, and <italic>Saccharomyces cerevisiae</italic>—and the proteins they are predicted to encode—was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0404511</journal-id><journal-id journal-id-type="pubmed-jr-id">7473</journal-id><journal-id journal-id-type="nlm-ta">Science</journal-id><journal-title>Science (New York, N.Y.)</journal-title><issn pub-type="ppub">0036-8075</issn><issn pub-type="epub">1095-9203</issn></journal-meta><article-meta><article-id pub-id-type="pmid">10731134</article-id><article-id pub-id-type="pmc">2754258</article-id><article-id pub-id-type="manuscript">NIHMS142596</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Comparative Genomics of the Eukaryotes</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rubin</surname><given-names>Gerald M.</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Yandell</surname><given-names>Mark D.</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Wortman</surname><given-names>Jennifer R.</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Gabor Miklos</surname><given-names>George L.</given-names></name><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Nelson</surname><given-names>Catherine R.</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Hariharan</surname><given-names>Iswar K.</given-names></name><xref rid="A5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Fortini</surname><given-names>Mark E.</given-names></name><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Peter W.</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Apweiler</surname><given-names>Rolf</given-names></name><xref rid="A7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Fleischmann</surname><given-names>Wolfgang</given-names></name><xref rid="A7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Cherry</surname><given-names>J. Michael</given-names></name><xref rid="A8" ref-type="aff">8</xref></contrib><contrib contrib-type="author"><name><surname>Henikoff</surname><given-names>Steven</given-names></name><xref rid="A9" ref-type="aff">9</xref></contrib><contrib contrib-type="author"><name><surname>Skupski</surname><given-names>Marian P.</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Misra</surname><given-names>Sima</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Ashburner</surname><given-names>Michael</given-names></name><xref rid="A7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Birney</surname><given-names>Ewan</given-names></name><xref rid="A7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Boguski</surname><given-names>Mark S.</given-names></name><xref rid="A10" ref-type="aff">10</xref></contrib><contrib contrib-type="author"><name><surname>Brody</surname><given-names>Thomas</given-names></name><xref rid="A11" ref-type="aff">11</xref></contrib><contrib contrib-type="author"><name><surname>Brokstein</surname><given-names>Peter</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Celniker</surname><given-names>Susan E.</given-names></name><xref rid="A12" ref-type="aff">12</xref></contrib><contrib contrib-type="author"><name><surname>Chervitz</surname><given-names>Stephen A.</given-names></name><xref rid="A13" ref-type="aff">13</xref></contrib><contrib contrib-type="author"><name><surname>Coates</surname><given-names>David</given-names></name><xref rid="A14" ref-type="aff">14</xref></contrib><contrib contrib-type="author"><name><surname>Cravchik</surname><given-names>Anibal</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Gabrielian</surname><given-names>Andrei</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Galle</surname><given-names>Richard F.</given-names></name><xref rid="A12" ref-type="aff">12</xref></contrib><contrib contrib-type="author"><name><surname>Gelbart</surname><given-names>William M.</given-names></name><xref rid="A15" ref-type="aff">15</xref></contrib><contrib contrib-type="author"><name><surname>George</surname><given-names>Reed A.</given-names></name><xref rid="A12" ref-type="aff">12</xref></contrib><contrib contrib-type="author"><name><surname>Goldstein</surname><given-names>Lawrence S. B.</given-names></name><xref rid="A16" ref-type="aff">16</xref></contrib><contrib contrib-type="author"><name><surname>Gong</surname><given-names>Fangcheng</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Guan</surname><given-names>Ping</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Harris</surname><given-names>Nomi L.</given-names></name><xref rid="A12" ref-type="aff">12</xref></contrib><contrib contrib-type="author"><name><surname>Hay</surname><given-names>Bruce A.</given-names></name><xref rid="A17" ref-type="aff">17</xref></contrib><contrib contrib-type="author"><name><surname>Hoskins</surname><given-names>Roger A.</given-names></name><xref rid="A12" ref-type="aff">12</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Jiayin</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Zhenya</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Hynes</surname><given-names>Richard O.</given-names></name><xref rid="A18" ref-type="aff">18</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>S. J. M.</given-names></name><xref rid="A19" ref-type="aff">19</xref></contrib><contrib contrib-type="author"><name><surname>Kuehl</surname><given-names>Peter M.</given-names></name><xref rid="A20" ref-type="aff">20</xref></contrib><contrib contrib-type="author"><name><surname>Lemaitre</surname><given-names>Bruno</given-names></name><xref rid="A21" ref-type="aff">21</xref></contrib><contrib contrib-type="author"><name><surname>Littleton</surname><given-names>J. Troy</given-names></name><xref rid="A22" ref-type="aff">22</xref></contrib><contrib contrib-type="author"><name><surname>Morrison</surname><given-names>Deborah K.</given-names></name><xref rid="A23" ref-type="aff">23</xref></contrib><contrib contrib-type="author"><name><surname>Mungall</surname><given-names>Chris</given-names></name><xref rid="A12" ref-type="aff">12</xref></contrib><contrib contrib-type="author"><name><surname>O'Farrell</surname><given-names>Patrick H.</given-names></name><xref rid="A24" ref-type="aff">24</xref></contrib><contrib contrib-type="author"><name><surname>Pickeral</surname><given-names>Oxana K.</given-names></name><xref rid="A10" ref-type="aff">10</xref></contrib><contrib contrib-type="author"><name><surname>Shue</surname><given-names>Chris</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Vosshall</surname><given-names>Leslie B.</given-names></name><xref rid="A25" ref-type="aff">25</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Jiong</given-names></name><xref rid="A10" ref-type="aff">10</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Qi</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Xiangqun H.</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Zhong</surname><given-names>Fei</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Zhong</surname><given-names>Wenyan</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Gibbs</surname><given-names>Richard</given-names></name><xref rid="A26" ref-type="aff">26</xref></contrib><contrib contrib-type="author"><name><surname>Venter</surname><given-names>J. Craig</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Adams</surname><given-names>Mark D.</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Lewis</surname><given-names>Suzanna</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Howard Hughes Medical Institute, Berkeley<italic>Drosophila</italic> Genome Project, University of California, Berkeley, CA 94720, USA</aff><aff id="A2"><label>2</label>Department of Molecular and Cell Biology, Berkeley<italic>Drosophila</italic> Genome Project, University of California, Berkeley, CA 94720, USA</aff><aff id="A3"><label>3</label>Celera Genomics, Rockville, MD, 20850 USA</aff><aff id="A4"><label>4</label>GenetixXpress, 78 Pacific Road, Palm Beach, Sydney, Australia 2108</aff><aff id="A5"><label>5</label>Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129 USA</aff><aff id="A6"><label>6</label>Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA</aff><aff id="A7"><label>7</label>EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</aff><aff id="A8"><label>8</label>Department of Genetics, Stanford University, Palo Alto, CA 94305, USA</aff><aff id="A9"><label>9</label>Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA</aff><aff id="A10"><label>10</label>National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA</aff><aff id="A11"><label>11</label>Neurogenetics Unit, Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA</aff><aff id="A12"><label>12</label>Berkeley<italic>Drosophila</italic> Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA</aff><aff id="A13"><label>13</label>Neomorphic, 2612 Eighth Street, Berkeley, CA 94710, USA</aff><aff id="A14"><label>14</label>School of Biology, University of Leeds, Leeds LS2 9JT, UK</aff><aff id="A15"><label>15</label>Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA</aff><aff id="A16"><label>16</label>Departments of Cellular and Molecular Medicine and Pharmacology, Howard Hughes Medical Institute, University of California–San Diego, La Jolla, CA 92093, USA</aff><aff id="A17"><label>17</label>Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA</aff><aff id="A18"><label>18</label>Howard Hughes Medical Institute, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA</aff><aff id="A19"><label>19</label>Genome Sequence Centre, BC Cancer Research Centre, 600 West 10th Avenue, Vancouver, BC, V52 4E6, Canada</aff><aff id="A20"><label>20</label>Molecular and Cell Biology Program, University of Maryland at Baltimore, Baltimore, MD 21201, USA</aff><aff id="A21"><label>21</label>Centre de Génétique Moléculaire, CNRS, 91198 Gif-sur-Yvette, France</aff><aff id="A22"><label>22</label>Center for Learning and Memory, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA</aff><aff id="A23"><label>23</label>Regulation of Cell Growth Laboratory, Division of Basic Sciences, National Cancer Institute–Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, MD 21702, USA</aff><aff id="A24"><label>24</label>Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA</aff><aff id="A25"><label>25</label>Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA</aff><aff id="A26"><label>26</label>Baylor College of Medicine Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA</aff><pub-date pub-type="nihms-submitted"><day>1</day><month>9</month><year>2009</year></pub-date><pub-date pub-type="ppub"><day>24</day><month>3</month><year>2000</year></pub-date><pub-date pub-type="pmc-release"><day>29</day><month>9</month><year>2009</year></pub-date><volume>287</volume><issue>5461</issue><fpage>2204</fpage><lpage>2215</lpage><abstract><p id="P1">A comparative analysis of the genomes of <italic>Drosophila melanogaster</italic>, <italic>Caenorhabditis elegans</italic>, and <italic>Saccharomyces cerevisiae</italic>—and the proteins they are predicted to encode—was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.</p></abstract><contract-num rid="GM1">R01 GM060988-01</contract-num><contract-num rid="GM1">R01 GM037193-15</contract-num><contract-num rid="GM1">R01 GM037193-14</contract-num><contract-sponsor id="GM1">National Institute of General Medical Sciences : NIGMS</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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