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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Patients with myeloid malignancies bearing <italic>PDGFRB</italic> fusion genes achieve durable long-term remissions with imatinib</title><author><name sortKey="Cheah, Chan Y" sort="Cheah, Chan Y" uniqKey="Cheah C" first="Chan Y." last="Cheah">Chan Y. Cheah</name><affiliation><nlm:aff id="aff1">Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">University of Melbourne, Parkville, VIC, Australia;</nlm:aff></affiliation></author><author><name sortKey="Burbury, Kate" sort="Burbury, Kate" uniqKey="Burbury K" first="Kate" last="Burbury">Kate Burbury</name><affiliation><nlm:aff id="aff1">Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">University of Melbourne, Parkville, VIC, Australia;</nlm:aff></affiliation></author><author><name sortKey="Apperley, Jane F" sort="Apperley, Jane F" uniqKey="Apperley J" first="Jane F." last="Apperley">Jane F. Apperley</name><affiliation><nlm:aff id="aff3">Department of Haematology, Faculty of Medicine, Imperial College London, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Huguet, Francoise" sort="Huguet, Francoise" uniqKey="Huguet F" first="Francoise" last="Huguet">Francoise Huguet</name><affiliation><nlm:aff id="aff4">Department of Haematology, Centre Hospitalier Universitaire, Toulouse, France;</nlm:aff></affiliation></author><author><name sortKey="Pitini, Vincenzo" sort="Pitini, Vincenzo" uniqKey="Pitini V" first="Vincenzo" last="Pitini">Vincenzo Pitini</name><affiliation><nlm:aff id="aff5">Oncologia Medica e Trapianto di Midollo Osseo, Messina, Italy;</nlm:aff></affiliation></author><author><name sortKey="Gardembas, Martine" sort="Gardembas, Martine" uniqKey="Gardembas M" first="Martine" last="Gardembas">Martine Gardembas</name><affiliation><nlm:aff id="aff6">Department of Haematology, Centre Hospitalier Universitaire, Angers, France;</nlm:aff></affiliation></author><author><name sortKey="Ross, David M" sort="Ross, David M" uniqKey="Ross D" first="David M." last="Ross">David M. Ross</name><affiliation><nlm:aff id="aff7">Haematology, South Australia Pathology, Adelaide, SA, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff8">School of Medicine, University of Adelaide, Adelaide, SA, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff9">School of Medicine, Flinders University, Adelaide, SA, Australia;</nlm:aff></affiliation></author><author><name sortKey="Forrest, Donna" sort="Forrest, Donna" uniqKey="Forrest D" first="Donna" last="Forrest">Donna Forrest</name><affiliation><nlm:aff id="aff10">British Columbia Cancer Agency, Vancouver, BC, Canada;</nlm:aff></affiliation></author><author><name sortKey="Genet, Philippe" sort="Genet, Philippe" uniqKey="Genet P" first="Philippe" last="Genet">Philippe Genet</name><affiliation><nlm:aff id="aff11">Department of Haematology, Hôpital Victor Dupouy, Argenteuil, France;</nlm:aff></affiliation></author><author><name sortKey="Rousselot, Philippe" sort="Rousselot, Philippe" uniqKey="Rousselot P" first="Philippe" last="Rousselot">Philippe Rousselot</name><affiliation><nlm:aff id="aff12">Department of Haematology, Hôpital de Versailles and Université de Versailles Saint-Quentin, Le Chesnay, France;</nlm:aff></affiliation></author><author><name sortKey="Patton, Nigel" sort="Patton, Nigel" uniqKey="Patton N" first="Nigel" last="Patton">Nigel Patton</name><affiliation><nlm:aff id="aff13">Department of Haematology, Auckland City Hospital, Auckland, New Zealand;</nlm:aff></affiliation></author><author><name sortKey="Smith, Graeme" sort="Smith, Graeme" uniqKey="Smith G" first="Graeme" last="Smith">Graeme Smith</name><affiliation><nlm:aff id="aff14">Department of Haematology, St. James’s University Hospital, Leeds, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Dunbar, Cynthia E" sort="Dunbar, Cynthia E" uniqKey="Dunbar C" first="Cynthia E." last="Dunbar">Cynthia E. Dunbar</name><affiliation><nlm:aff id="aff15">Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Ito, Sawa" sort="Ito, Sawa" uniqKey="Ito S" first="Sawa" last="Ito">Sawa Ito</name><affiliation><nlm:aff id="aff15">Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Aguiar, Ricardo C T" sort="Aguiar, Ricardo C T" uniqKey="Aguiar R" first="Ricardo C. T." last="Aguiar">Ricardo C. T. Aguiar</name><affiliation><nlm:aff id="aff16">Department of Medicine, University of Texas Health Science Center, San Antonio, TX;</nlm:aff></affiliation><affiliation><nlm:aff id="aff17">Audie Murphy Veterans Affairs Hospital, San Antonio, TX;</nlm:aff></affiliation></author><author><name sortKey="Odenike, Olatoyosi" sort="Odenike, Olatoyosi" uniqKey="Odenike O" first="Olatoyosi" last="Odenike">Olatoyosi Odenike</name><affiliation><nlm:aff id="aff18">Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL;</nlm:aff></affiliation></author><author><name sortKey="Gimelfarb, Alla" sort="Gimelfarb, Alla" uniqKey="Gimelfarb A" first="Alla" last="Gimelfarb">Alla Gimelfarb</name><affiliation><nlm:aff id="aff19">Northshore University Health Systems, Chicago, IL;</nlm:aff></affiliation></author><author><name sortKey="Cross, Nicholas C P" sort="Cross, Nicholas C P" uniqKey="Cross N" first="Nicholas C. P." last="Cross">Nicholas C. P. Cross</name><affiliation><nlm:aff id="aff20">Faculty of Medicine, University of Southampton, Southampton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Seymour, John F" sort="Seymour, John F" uniqKey="Seymour J" first="John F." last="Seymour">John F. Seymour</name><affiliation><nlm:aff id="aff1">Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">University of Melbourne, Parkville, VIC, Australia;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24687085</idno><idno type="pmc">4047496</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047496</idno><idno type="RBID">PMC:4047496</idno><idno type="doi">10.1182/blood-2014-02-555607</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001230</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001230</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Patients with myeloid malignancies bearing <italic>PDGFRB</italic> fusion genes achieve durable long-term remissions with imatinib</title><author><name sortKey="Cheah, Chan Y" sort="Cheah, Chan Y" uniqKey="Cheah C" first="Chan Y." last="Cheah">Chan Y. Cheah</name><affiliation><nlm:aff id="aff1">Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">University of Melbourne, Parkville, VIC, Australia;</nlm:aff></affiliation></author><author><name sortKey="Burbury, Kate" sort="Burbury, Kate" uniqKey="Burbury K" first="Kate" last="Burbury">Kate Burbury</name><affiliation><nlm:aff id="aff1">Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">University of Melbourne, Parkville, VIC, Australia;</nlm:aff></affiliation></author><author><name sortKey="Apperley, Jane F" sort="Apperley, Jane F" uniqKey="Apperley J" first="Jane F." last="Apperley">Jane F. Apperley</name><affiliation><nlm:aff id="aff3">Department of Haematology, Faculty of Medicine, Imperial College London, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Huguet, Francoise" sort="Huguet, Francoise" uniqKey="Huguet F" first="Francoise" last="Huguet">Francoise Huguet</name><affiliation><nlm:aff id="aff4">Department of Haematology, Centre Hospitalier Universitaire, Toulouse, France;</nlm:aff></affiliation></author><author><name sortKey="Pitini, Vincenzo" sort="Pitini, Vincenzo" uniqKey="Pitini V" first="Vincenzo" last="Pitini">Vincenzo Pitini</name><affiliation><nlm:aff id="aff5">Oncologia Medica e Trapianto di Midollo Osseo, Messina, Italy;</nlm:aff></affiliation></author><author><name sortKey="Gardembas, Martine" sort="Gardembas, Martine" uniqKey="Gardembas M" first="Martine" last="Gardembas">Martine Gardembas</name><affiliation><nlm:aff id="aff6">Department of Haematology, Centre Hospitalier Universitaire, Angers, France;</nlm:aff></affiliation></author><author><name sortKey="Ross, David M" sort="Ross, David M" uniqKey="Ross D" first="David M." last="Ross">David M. Ross</name><affiliation><nlm:aff id="aff7">Haematology, South Australia Pathology, Adelaide, SA, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff8">School of Medicine, University of Adelaide, Adelaide, SA, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff9">School of Medicine, Flinders University, Adelaide, SA, Australia;</nlm:aff></affiliation></author><author><name sortKey="Forrest, Donna" sort="Forrest, Donna" uniqKey="Forrest D" first="Donna" last="Forrest">Donna Forrest</name><affiliation><nlm:aff id="aff10">British Columbia Cancer Agency, Vancouver, BC, Canada;</nlm:aff></affiliation></author><author><name sortKey="Genet, Philippe" sort="Genet, Philippe" uniqKey="Genet P" first="Philippe" last="Genet">Philippe Genet</name><affiliation><nlm:aff id="aff11">Department of Haematology, Hôpital Victor Dupouy, Argenteuil, France;</nlm:aff></affiliation></author><author><name sortKey="Rousselot, Philippe" sort="Rousselot, Philippe" uniqKey="Rousselot P" first="Philippe" last="Rousselot">Philippe Rousselot</name><affiliation><nlm:aff id="aff12">Department of Haematology, Hôpital de Versailles and Université de Versailles Saint-Quentin, Le Chesnay, France;</nlm:aff></affiliation></author><author><name sortKey="Patton, Nigel" sort="Patton, Nigel" uniqKey="Patton N" first="Nigel" last="Patton">Nigel Patton</name><affiliation><nlm:aff id="aff13">Department of Haematology, Auckland City Hospital, Auckland, New Zealand;</nlm:aff></affiliation></author><author><name sortKey="Smith, Graeme" sort="Smith, Graeme" uniqKey="Smith G" first="Graeme" last="Smith">Graeme Smith</name><affiliation><nlm:aff id="aff14">Department of Haematology, St. James’s University Hospital, Leeds, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Dunbar, Cynthia E" sort="Dunbar, Cynthia E" uniqKey="Dunbar C" first="Cynthia E." last="Dunbar">Cynthia E. Dunbar</name><affiliation><nlm:aff id="aff15">Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Ito, Sawa" sort="Ito, Sawa" uniqKey="Ito S" first="Sawa" last="Ito">Sawa Ito</name><affiliation><nlm:aff id="aff15">Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Aguiar, Ricardo C T" sort="Aguiar, Ricardo C T" uniqKey="Aguiar R" first="Ricardo C. T." last="Aguiar">Ricardo C. T. Aguiar</name><affiliation><nlm:aff id="aff16">Department of Medicine, University of Texas Health Science Center, San Antonio, TX;</nlm:aff></affiliation><affiliation><nlm:aff id="aff17">Audie Murphy Veterans Affairs Hospital, San Antonio, TX;</nlm:aff></affiliation></author><author><name sortKey="Odenike, Olatoyosi" sort="Odenike, Olatoyosi" uniqKey="Odenike O" first="Olatoyosi" last="Odenike">Olatoyosi Odenike</name><affiliation><nlm:aff id="aff18">Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL;</nlm:aff></affiliation></author><author><name sortKey="Gimelfarb, Alla" sort="Gimelfarb, Alla" uniqKey="Gimelfarb A" first="Alla" last="Gimelfarb">Alla Gimelfarb</name><affiliation><nlm:aff id="aff19">Northshore University Health Systems, Chicago, IL;</nlm:aff></affiliation></author><author><name sortKey="Cross, Nicholas C P" sort="Cross, Nicholas C P" uniqKey="Cross N" first="Nicholas C. P." last="Cross">Nicholas C. P. Cross</name><affiliation><nlm:aff id="aff20">Faculty of Medicine, University of Southampton, Southampton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Seymour, John F" sort="Seymour, John F" uniqKey="Seymour J" first="John F." last="Seymour">John F. Seymour</name><affiliation><nlm:aff id="aff1">Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">University of Melbourne, Parkville, VIC, Australia;</nlm:aff></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p><list list-type="bullet"><list-item><p>Imatinib achieves deep and durable remissions in patients with myeloid neoplasms bearing <italic>PDGFRB.</italic></p></list-item><list-item><p>Allogeneic stem cell transplantation is no longer indicated for patients with chronic myeloproliferative neoplasm bearing <italic>PDGFRB</italic> who respond to imatinib.</p></list-item></list></p></div></front></TEI><pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id><journal-id journal-id-type="iso-abbrev">Blood</journal-id><journal-id journal-id-type="hwp">bloodjournal</journal-id><journal-id journal-id-type="pmc">blood</journal-id><journal-id journal-id-type="publisher-id">Blood</journal-id><journal-title-group><journal-title>Blood</journal-title></journal-title-group><issn pub-type="ppub">0006-4971</issn><issn pub-type="epub">1528-0020</issn><publisher><publisher-name>American Society of Hematology</publisher-name><publisher-loc>Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24687085</article-id><article-id pub-id-type="pmc">4047496</article-id><article-id pub-id-type="publisher-id">2014/555607</article-id><article-id pub-id-type="doi">10.1182/blood-2014-02-555607</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>6</subject><subject>29</subject><subject>8</subject><subject>33</subject><subject>37</subject></subj-group><subj-group subj-group-type="heading"><subject>Clinical Trials and Observations</subject></subj-group><subj-group subj-group-type="leader"><subject>Brief Report</subject></subj-group></article-categories><title-group><article-title>Patients with myeloid malignancies bearing <italic>PDGFRB</italic> fusion genes achieve durable long-term remissions with imatinib</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cheah</surname><given-names>Chan Y.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Burbury</surname><given-names>Kate</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Apperley</surname><given-names>Jane F.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Huguet</surname><given-names>Francoise</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Pitini</surname><given-names>Vincenzo</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Gardembas</surname><given-names>Martine</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Ross</surname><given-names>David M.</given-names></name><xref ref-type="aff" rid="aff7">7</xref><xref ref-type="aff" rid="aff8">8</xref><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Forrest</surname><given-names>Donna</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Genet</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Rousselot</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Patton</surname><given-names>Nigel</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Graeme</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Dunbar</surname><given-names>Cynthia E.</given-names></name><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Ito</surname><given-names>Sawa</given-names></name><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Aguiar</surname><given-names>Ricardo C. T.</given-names></name><xref ref-type="aff" rid="aff16">16</xref><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>Odenike</surname><given-names>Olatoyosi</given-names></name><xref ref-type="aff" rid="aff18">18</xref></contrib><contrib contrib-type="author"><name><surname>Gimelfarb</surname><given-names>Alla</given-names></name><xref ref-type="aff" rid="aff19">19</xref></contrib><contrib contrib-type="author"><name><surname>Cross</surname><given-names>Nicholas C. P.</given-names></name><xref ref-type="aff" rid="aff20">20</xref></contrib><contrib contrib-type="author"><name><surname>Seymour</surname><given-names>John F.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><aff id="aff1"><label>1</label>Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</aff><aff id="aff2"><label>2</label>University of Melbourne, Parkville, VIC, Australia;</aff><aff id="aff3"><label>3</label>Department of Haematology, Faculty of Medicine, Imperial College London, London, United Kingdom;</aff><aff id="aff4"><label>4</label>Department of Haematology, Centre Hospitalier Universitaire, Toulouse, France;</aff><aff id="aff5"><label>5</label>Oncologia Medica e Trapianto di Midollo Osseo, Messina, Italy;</aff><aff id="aff6"><label>6</label>Department of Haematology, Centre Hospitalier Universitaire, Angers, France;</aff><aff id="aff7"><label>7</label>Haematology, South Australia Pathology, Adelaide, SA, Australia;</aff><aff id="aff8"><label>8</label>School of Medicine, University of Adelaide, Adelaide, SA, Australia;</aff><aff id="aff9"><label>9</label>School of Medicine, Flinders University, Adelaide, SA, Australia;</aff><aff id="aff10"><label>10</label>British Columbia Cancer Agency, Vancouver, BC, Canada;</aff><aff id="aff11"><label>11</label>Department of Haematology, Hôpital Victor Dupouy, Argenteuil, France;</aff><aff id="aff12"><label>12</label>Department of Haematology, Hôpital de Versailles and Université de Versailles Saint-Quentin, Le Chesnay, France;</aff><aff id="aff13"><label>13</label>Department of Haematology, Auckland City Hospital, Auckland, New Zealand;</aff><aff id="aff14"><label>14</label>Department of Haematology, St. James’s University Hospital, Leeds, United Kingdom;</aff><aff id="aff15"><label>15</label>Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD;</aff><aff id="aff16"><label>16</label>Department of Medicine, University of Texas Health Science Center, San Antonio, TX;</aff><aff id="aff17"><label>17</label>Audie Murphy Veterans Affairs Hospital, San Antonio, TX;</aff><aff id="aff18"><label>18</label>Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL;</aff><aff id="aff19"><label>19</label>Northshore University Health Systems, Chicago, IL;</aff><aff id="aff20"><label>20</label>Faculty of Medicine, University of Southampton, Southampton, United Kingdom</aff></contrib-group><pub-date pub-type="ppub"><day>5</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="epreprint"><day>31</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>5</day><month>6</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>123</volume><issue>23</issue><fpage>3574</fpage><lpage>3577</lpage><history><date date-type="received"><day>18</day><month>2</month><year>2014</year></date><date date-type="accepted"><day>24</day><month>3</month><year>2014</year></date></history><permissions><copyright-year>2014</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="3574.pdf"></self-uri><related-article related-article-type="article-reference" id="d35e342" vol="123" page="3526" issue="23" ext-link-type="pmc"></related-article><abstract abstract-type="executive-summary"><title>Key Points</title><p><list list-type="bullet"><list-item><p>Imatinib achieves deep and durable remissions in patients with myeloid neoplasms bearing <italic>PDGFRB.</italic></p></list-item><list-item><p>Allogeneic stem cell transplantation is no longer indicated for patients with chronic myeloproliferative neoplasm bearing <italic>PDGFRB</italic> who respond to imatinib.</p></list-item></list></p></abstract><abstract><p>Myeloid neoplasms and eosinophilia with rearrangements of <italic>PDGFRB</italic> are uncommon Philadelphia-negative myeloproliferative neoplasms. Patients are typically male, with morphologic features of a Philadelphia-negative chronic myeloproliferative syndrome or chronic myelomonocytic leukemia with eosinophilia. Reciprocal translocations involving <italic>PDGFRB</italic> result in fusion genes with constitutively activated receptor tyrosine kinase sensitive to inhibition with imatinib. We present an updated and expanded analysis of a cohort of 26 such patients treated with imatinib. After a median follow-up of 10.2 years (range, 1.8-17 years), the 10-year overall survival rate was 90% (95% confidence interval, 64%-97%); after median imatinib duration of 6.6 years (range, 0.1-12 years), the 6-year progression-free survival rate was 88% (95% confidence interval, 65%-96%). Of the patients, 96% responded; no patients who achieved a complete cytogenetic (n = 13) or molecular (n = 8) remission lost their response or progressed to blast crisis. Imatinib is well-tolerated and achieves excellent long-term responses in patients with <italic>PDGFRB</italic> rearrangements.</p></abstract><counts><page-count count="4"></page-count></counts><custom-meta-group><custom-meta><meta-name>access</meta-name><meta-value>free</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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