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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Patients with myeloid malignancies bearing <italic>PDGFRB</italic>
fusion genes achieve durable long-term remissions with imatinib</title>
<author><name sortKey="Cheah, Chan Y" sort="Cheah, Chan Y" uniqKey="Cheah C" first="Chan Y." last="Cheah">Chan Y. Cheah</name>
<affiliation><nlm:aff id="aff1">Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">University of Melbourne, Parkville, VIC, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Burbury, Kate" sort="Burbury, Kate" uniqKey="Burbury K" first="Kate" last="Burbury">Kate Burbury</name>
<affiliation><nlm:aff id="aff1">Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">University of Melbourne, Parkville, VIC, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Apperley, Jane F" sort="Apperley, Jane F" uniqKey="Apperley J" first="Jane F." last="Apperley">Jane F. Apperley</name>
<affiliation><nlm:aff id="aff3">Department of Haematology, Faculty of Medicine, Imperial College London, London, United Kingdom;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Huguet, Francoise" sort="Huguet, Francoise" uniqKey="Huguet F" first="Francoise" last="Huguet">Francoise Huguet</name>
<affiliation><nlm:aff id="aff4">Department of Haematology, Centre Hospitalier Universitaire, Toulouse, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pitini, Vincenzo" sort="Pitini, Vincenzo" uniqKey="Pitini V" first="Vincenzo" last="Pitini">Vincenzo Pitini</name>
<affiliation><nlm:aff id="aff5">Oncologia Medica e Trapianto di Midollo Osseo, Messina, Italy;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gardembas, Martine" sort="Gardembas, Martine" uniqKey="Gardembas M" first="Martine" last="Gardembas">Martine Gardembas</name>
<affiliation><nlm:aff id="aff6">Department of Haematology, Centre Hospitalier Universitaire, Angers, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ross, David M" sort="Ross, David M" uniqKey="Ross D" first="David M." last="Ross">David M. Ross</name>
<affiliation><nlm:aff id="aff7">Haematology, South Australia Pathology, Adelaide, SA, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff8">School of Medicine, University of Adelaide, Adelaide, SA, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff9">School of Medicine, Flinders University, Adelaide, SA, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Forrest, Donna" sort="Forrest, Donna" uniqKey="Forrest D" first="Donna" last="Forrest">Donna Forrest</name>
<affiliation><nlm:aff id="aff10">British Columbia Cancer Agency, Vancouver, BC, Canada;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Genet, Philippe" sort="Genet, Philippe" uniqKey="Genet P" first="Philippe" last="Genet">Philippe Genet</name>
<affiliation><nlm:aff id="aff11">Department of Haematology, Hôpital Victor Dupouy, Argenteuil, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rousselot, Philippe" sort="Rousselot, Philippe" uniqKey="Rousselot P" first="Philippe" last="Rousselot">Philippe Rousselot</name>
<affiliation><nlm:aff id="aff12">Department of Haematology, Hôpital de Versailles and Université de Versailles Saint-Quentin, Le Chesnay, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Patton, Nigel" sort="Patton, Nigel" uniqKey="Patton N" first="Nigel" last="Patton">Nigel Patton</name>
<affiliation><nlm:aff id="aff13">Department of Haematology, Auckland City Hospital, Auckland, New Zealand;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smith, Graeme" sort="Smith, Graeme" uniqKey="Smith G" first="Graeme" last="Smith">Graeme Smith</name>
<affiliation><nlm:aff id="aff14">Department of Haematology, St. James’s University Hospital, Leeds, United Kingdom;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dunbar, Cynthia E" sort="Dunbar, Cynthia E" uniqKey="Dunbar C" first="Cynthia E." last="Dunbar">Cynthia E. Dunbar</name>
<affiliation><nlm:aff id="aff15">Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ito, Sawa" sort="Ito, Sawa" uniqKey="Ito S" first="Sawa" last="Ito">Sawa Ito</name>
<affiliation><nlm:aff id="aff15">Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aguiar, Ricardo C T" sort="Aguiar, Ricardo C T" uniqKey="Aguiar R" first="Ricardo C. T." last="Aguiar">Ricardo C. T. Aguiar</name>
<affiliation><nlm:aff id="aff16">Department of Medicine, University of Texas Health Science Center, San Antonio, TX;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff17">Audie Murphy Veterans Affairs Hospital, San Antonio, TX;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Odenike, Olatoyosi" sort="Odenike, Olatoyosi" uniqKey="Odenike O" first="Olatoyosi" last="Odenike">Olatoyosi Odenike</name>
<affiliation><nlm:aff id="aff18">Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gimelfarb, Alla" sort="Gimelfarb, Alla" uniqKey="Gimelfarb A" first="Alla" last="Gimelfarb">Alla Gimelfarb</name>
<affiliation><nlm:aff id="aff19">Northshore University Health Systems, Chicago, IL;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cross, Nicholas C P" sort="Cross, Nicholas C P" uniqKey="Cross N" first="Nicholas C. P." last="Cross">Nicholas C. P. Cross</name>
<affiliation><nlm:aff id="aff20">Faculty of Medicine, University of Southampton, Southampton, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Seymour, John F" sort="Seymour, John F" uniqKey="Seymour J" first="John F." last="Seymour">John F. Seymour</name>
<affiliation><nlm:aff id="aff1">Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">University of Melbourne, Parkville, VIC, Australia;</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24687085</idno>
<idno type="pmc">4047496</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047496</idno>
<idno type="RBID">PMC:4047496</idno>
<idno type="doi">10.1182/blood-2014-02-555607</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001230</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001230</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Patients with myeloid malignancies bearing <italic>PDGFRB</italic>
fusion genes achieve durable long-term remissions with imatinib</title>
<author><name sortKey="Cheah, Chan Y" sort="Cheah, Chan Y" uniqKey="Cheah C" first="Chan Y." last="Cheah">Chan Y. Cheah</name>
<affiliation><nlm:aff id="aff1">Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">University of Melbourne, Parkville, VIC, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Burbury, Kate" sort="Burbury, Kate" uniqKey="Burbury K" first="Kate" last="Burbury">Kate Burbury</name>
<affiliation><nlm:aff id="aff1">Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">University of Melbourne, Parkville, VIC, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Apperley, Jane F" sort="Apperley, Jane F" uniqKey="Apperley J" first="Jane F." last="Apperley">Jane F. Apperley</name>
<affiliation><nlm:aff id="aff3">Department of Haematology, Faculty of Medicine, Imperial College London, London, United Kingdom;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Huguet, Francoise" sort="Huguet, Francoise" uniqKey="Huguet F" first="Francoise" last="Huguet">Francoise Huguet</name>
<affiliation><nlm:aff id="aff4">Department of Haematology, Centre Hospitalier Universitaire, Toulouse, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pitini, Vincenzo" sort="Pitini, Vincenzo" uniqKey="Pitini V" first="Vincenzo" last="Pitini">Vincenzo Pitini</name>
<affiliation><nlm:aff id="aff5">Oncologia Medica e Trapianto di Midollo Osseo, Messina, Italy;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gardembas, Martine" sort="Gardembas, Martine" uniqKey="Gardembas M" first="Martine" last="Gardembas">Martine Gardembas</name>
<affiliation><nlm:aff id="aff6">Department of Haematology, Centre Hospitalier Universitaire, Angers, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ross, David M" sort="Ross, David M" uniqKey="Ross D" first="David M." last="Ross">David M. Ross</name>
<affiliation><nlm:aff id="aff7">Haematology, South Australia Pathology, Adelaide, SA, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff8">School of Medicine, University of Adelaide, Adelaide, SA, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff9">School of Medicine, Flinders University, Adelaide, SA, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Forrest, Donna" sort="Forrest, Donna" uniqKey="Forrest D" first="Donna" last="Forrest">Donna Forrest</name>
<affiliation><nlm:aff id="aff10">British Columbia Cancer Agency, Vancouver, BC, Canada;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Genet, Philippe" sort="Genet, Philippe" uniqKey="Genet P" first="Philippe" last="Genet">Philippe Genet</name>
<affiliation><nlm:aff id="aff11">Department of Haematology, Hôpital Victor Dupouy, Argenteuil, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rousselot, Philippe" sort="Rousselot, Philippe" uniqKey="Rousselot P" first="Philippe" last="Rousselot">Philippe Rousselot</name>
<affiliation><nlm:aff id="aff12">Department of Haematology, Hôpital de Versailles and Université de Versailles Saint-Quentin, Le Chesnay, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Patton, Nigel" sort="Patton, Nigel" uniqKey="Patton N" first="Nigel" last="Patton">Nigel Patton</name>
<affiliation><nlm:aff id="aff13">Department of Haematology, Auckland City Hospital, Auckland, New Zealand;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smith, Graeme" sort="Smith, Graeme" uniqKey="Smith G" first="Graeme" last="Smith">Graeme Smith</name>
<affiliation><nlm:aff id="aff14">Department of Haematology, St. James’s University Hospital, Leeds, United Kingdom;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dunbar, Cynthia E" sort="Dunbar, Cynthia E" uniqKey="Dunbar C" first="Cynthia E." last="Dunbar">Cynthia E. Dunbar</name>
<affiliation><nlm:aff id="aff15">Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ito, Sawa" sort="Ito, Sawa" uniqKey="Ito S" first="Sawa" last="Ito">Sawa Ito</name>
<affiliation><nlm:aff id="aff15">Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aguiar, Ricardo C T" sort="Aguiar, Ricardo C T" uniqKey="Aguiar R" first="Ricardo C. T." last="Aguiar">Ricardo C. T. Aguiar</name>
<affiliation><nlm:aff id="aff16">Department of Medicine, University of Texas Health Science Center, San Antonio, TX;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff17">Audie Murphy Veterans Affairs Hospital, San Antonio, TX;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Odenike, Olatoyosi" sort="Odenike, Olatoyosi" uniqKey="Odenike O" first="Olatoyosi" last="Odenike">Olatoyosi Odenike</name>
<affiliation><nlm:aff id="aff18">Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gimelfarb, Alla" sort="Gimelfarb, Alla" uniqKey="Gimelfarb A" first="Alla" last="Gimelfarb">Alla Gimelfarb</name>
<affiliation><nlm:aff id="aff19">Northshore University Health Systems, Chicago, IL;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cross, Nicholas C P" sort="Cross, Nicholas C P" uniqKey="Cross N" first="Nicholas C. P." last="Cross">Nicholas C. P. Cross</name>
<affiliation><nlm:aff id="aff20">Faculty of Medicine, University of Southampton, Southampton, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Seymour, John F" sort="Seymour, John F" uniqKey="Seymour J" first="John F." last="Seymour">John F. Seymour</name>
<affiliation><nlm:aff id="aff1">Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">University of Melbourne, Parkville, VIC, Australia;</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="ISSN">0006-4971</idno>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Key Points</title>
<p><list list-type="bullet"><list-item><p>Imatinib achieves deep and durable remissions in patients with myeloid neoplasms bearing <italic>PDGFRB.</italic>
</p>
</list-item>
<list-item><p>Allogeneic stem cell transplantation is no longer indicated for patients with chronic myeloproliferative neoplasm bearing <italic>PDGFRB</italic>
who respond to imatinib.</p>
</list-item>
</list>
</p>
</div>
</front>
</TEI>
<pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id>
<journal-id journal-id-type="iso-abbrev">Blood</journal-id>
<journal-id journal-id-type="hwp">bloodjournal</journal-id>
<journal-id journal-id-type="pmc">blood</journal-id>
<journal-id journal-id-type="publisher-id">Blood</journal-id>
<journal-title-group><journal-title>Blood</journal-title>
</journal-title-group>
<issn pub-type="ppub">0006-4971</issn>
<issn pub-type="epub">1528-0020</issn>
<publisher><publisher-name>American Society of Hematology</publisher-name>
<publisher-loc>Washington, DC</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24687085</article-id>
<article-id pub-id-type="pmc">4047496</article-id>
<article-id pub-id-type="publisher-id">2014/555607</article-id>
<article-id pub-id-type="doi">10.1182/blood-2014-02-555607</article-id>
<article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>6</subject>
<subject>29</subject>
<subject>8</subject>
<subject>33</subject>
<subject>37</subject>
</subj-group>
<subj-group subj-group-type="heading"><subject>Clinical Trials and Observations</subject>
</subj-group>
<subj-group subj-group-type="leader"><subject>Brief Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Patients with myeloid malignancies bearing <italic>PDGFRB</italic>
fusion genes achieve durable long-term remissions with imatinib</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Cheah</surname>
<given-names>Chan Y.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Burbury</surname>
<given-names>Kate</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Apperley</surname>
<given-names>Jane F.</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huguet</surname>
<given-names>Francoise</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pitini</surname>
<given-names>Vincenzo</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gardembas</surname>
<given-names>Martine</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ross</surname>
<given-names>David M.</given-names>
</name>
<xref ref-type="aff" rid="aff7">7</xref>
<xref ref-type="aff" rid="aff8">8</xref>
<xref ref-type="aff" rid="aff9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Forrest</surname>
<given-names>Donna</given-names>
</name>
<xref ref-type="aff" rid="aff10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Genet</surname>
<given-names>Philippe</given-names>
</name>
<xref ref-type="aff" rid="aff11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rousselot</surname>
<given-names>Philippe</given-names>
</name>
<xref ref-type="aff" rid="aff12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Patton</surname>
<given-names>Nigel</given-names>
</name>
<xref ref-type="aff" rid="aff13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smith</surname>
<given-names>Graeme</given-names>
</name>
<xref ref-type="aff" rid="aff14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dunbar</surname>
<given-names>Cynthia E.</given-names>
</name>
<xref ref-type="aff" rid="aff15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ito</surname>
<given-names>Sawa</given-names>
</name>
<xref ref-type="aff" rid="aff15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aguiar</surname>
<given-names>Ricardo C. T.</given-names>
</name>
<xref ref-type="aff" rid="aff16">16</xref>
<xref ref-type="aff" rid="aff17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Odenike</surname>
<given-names>Olatoyosi</given-names>
</name>
<xref ref-type="aff" rid="aff18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gimelfarb</surname>
<given-names>Alla</given-names>
</name>
<xref ref-type="aff" rid="aff19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cross</surname>
<given-names>Nicholas C. P.</given-names>
</name>
<xref ref-type="aff" rid="aff20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Seymour</surname>
<given-names>John F.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<aff id="aff1"><label>1</label>
Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;</aff>
<aff id="aff2"><label>2</label>
University of Melbourne, Parkville, VIC, Australia;</aff>
<aff id="aff3"><label>3</label>
Department of Haematology, Faculty of Medicine, Imperial College London, London, United Kingdom;</aff>
<aff id="aff4"><label>4</label>
Department of Haematology, Centre Hospitalier Universitaire, Toulouse, France;</aff>
<aff id="aff5"><label>5</label>
Oncologia Medica e Trapianto di Midollo Osseo, Messina, Italy;</aff>
<aff id="aff6"><label>6</label>
Department of Haematology, Centre Hospitalier Universitaire, Angers, France;</aff>
<aff id="aff7"><label>7</label>
Haematology, South Australia Pathology, Adelaide, SA, Australia;</aff>
<aff id="aff8"><label>8</label>
School of Medicine, University of Adelaide, Adelaide, SA, Australia;</aff>
<aff id="aff9"><label>9</label>
School of Medicine, Flinders University, Adelaide, SA, Australia;</aff>
<aff id="aff10"><label>10</label>
British Columbia Cancer Agency, Vancouver, BC, Canada;</aff>
<aff id="aff11"><label>11</label>
Department of Haematology, Hôpital Victor Dupouy, Argenteuil, France;</aff>
<aff id="aff12"><label>12</label>
Department of Haematology, Hôpital de Versailles and Université de Versailles Saint-Quentin, Le Chesnay, France;</aff>
<aff id="aff13"><label>13</label>
Department of Haematology, Auckland City Hospital, Auckland, New Zealand;</aff>
<aff id="aff14"><label>14</label>
Department of Haematology, St. James’s University Hospital, Leeds, United Kingdom;</aff>
<aff id="aff15"><label>15</label>
Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD;</aff>
<aff id="aff16"><label>16</label>
Department of Medicine, University of Texas Health Science Center, San Antonio, TX;</aff>
<aff id="aff17"><label>17</label>
Audie Murphy Veterans Affairs Hospital, San Antonio, TX;</aff>
<aff id="aff18"><label>18</label>
Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL;</aff>
<aff id="aff19"><label>19</label>
Northshore University Health Systems, Chicago, IL;</aff>
<aff id="aff20"><label>20</label>
Faculty of Medicine, University of Southampton, Southampton, United Kingdom</aff>
</contrib-group>
<pub-date pub-type="ppub"><day>5</day>
<month>6</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epreprint"><day>31</day>
<month>3</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>5</day>
<month>6</month>
<year>2015</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and
0 days and was based on the . </pmc-comment>
<volume>123</volume>
<issue>23</issue>
<fpage>3574</fpage>
<lpage>3577</lpage>
<history><date date-type="received"><day>18</day>
<month>2</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>24</day>
<month>3</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-year>2014</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="3574.pdf"></self-uri>
<related-article related-article-type="article-reference" id="d35e342" vol="123" page="3526" issue="23" ext-link-type="pmc"></related-article>
<abstract abstract-type="executive-summary"><title>Key Points</title>
<p><list list-type="bullet"><list-item><p>Imatinib achieves deep and durable remissions in patients with myeloid neoplasms bearing <italic>PDGFRB.</italic>
</p>
</list-item>
<list-item><p>Allogeneic stem cell transplantation is no longer indicated for patients with chronic myeloproliferative neoplasm bearing <italic>PDGFRB</italic>
who respond to imatinib.</p>
</list-item>
</list>
</p>
</abstract>
<abstract><p>Myeloid neoplasms and eosinophilia with rearrangements of <italic>PDGFRB</italic>
are uncommon Philadelphia-negative myeloproliferative neoplasms. Patients are typically male, with morphologic features of a Philadelphia-negative chronic myeloproliferative syndrome or chronic myelomonocytic leukemia with eosinophilia. Reciprocal translocations involving <italic>PDGFRB</italic>
result in fusion genes with constitutively activated receptor tyrosine kinase sensitive to inhibition with imatinib. We present an updated and expanded analysis of a cohort of 26 such patients treated with imatinib. After a median follow-up of 10.2 years (range, 1.8-17 years), the 10-year overall survival rate was 90% (95% confidence interval, 64%-97%); after median imatinib duration of 6.6 years (range, 0.1-12 years), the 6-year progression-free survival rate was 88% (95% confidence interval, 65%-96%). Of the patients, 96% responded; no patients who achieved a complete cytogenetic (n = 13) or molecular (n = 8) remission lost their response or progressed to blast crisis. Imatinib is well-tolerated and achieves excellent long-term responses in patients with <italic>PDGFRB</italic>
rearrangements.</p>
</abstract>
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</front>
</pmc>
</record>
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