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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region</title>
<author><name sortKey="Skibola, Christine F" sort="Skibola, Christine F" uniqKey="Skibola C" first="Christine F." last="Skibola">Christine F. Skibola</name>
<affiliation><nlm:aff id="aff1">Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, AL 35233, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name>
<affiliation><nlm:aff id="aff4">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Conde, Lucia" sort="Conde, Lucia" uniqKey="Conde L" first="Lucia" last="Conde">Lucia Conde</name>
<affiliation><nlm:aff id="aff1">Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, AL 35233, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name>
<affiliation><nlm:aff id="aff5">Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name>
<affiliation><nlm:aff id="aff5">Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name>
<affiliation><nlm:aff id="aff6">Department of Medical Genetics and of Epidemiology, University Medical Center Utrecht, Utrecht 3584 CG, the Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff7">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Birmann, Brenda M" sort="Birmann, Brenda M" uniqKey="Birmann B" first="Brenda M." last="Birmann">Brenda M. Birmann</name>
<affiliation><nlm:aff id="aff8">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vajdic, Claire M" sort="Vajdic, Claire M" uniqKey="Vajdic C" first="Claire M." last="Vajdic">Claire M. Vajdic</name>
<affiliation><nlm:aff id="aff9">Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia-Nee" last="Foo">Jia-Nee Foo</name>
<affiliation><nlm:aff id="aff10">Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M." last="Bracci">Paige M. Bracci</name>
<affiliation><nlm:aff id="aff11">Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA 94118, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vermeulen, Roel C H" sort="Vermeulen, Roel C H" uniqKey="Vermeulen R" first="Roel C. H." last="Vermeulen">Roel C. H. Vermeulen</name>
<affiliation><nlm:aff id="aff7">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff12">Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Slager, Susan L" sort="Slager, Susan L" uniqKey="Slager S" first="Susan L." last="Slager">Susan L. Slager</name>
<affiliation><nlm:aff id="aff13">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjose">Silvia De Sanjose</name>
<affiliation><nlm:aff id="aff14">Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d’Oncologia, IDIBELL, Barcelona 8907, Spain</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff15">Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona 8036, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Sophia S" sort="Wang, Sophia S" uniqKey="Wang S" first="Sophia S." last="Wang">Sophia S. Wang</name>
<affiliation><nlm:aff id="aff16">Department of Cancer Etiology, City of Hope Beckman Research Institute, Duarte, CA 91030, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Linet, Martha S" sort="Linet, Martha S" uniqKey="Linet M" first="Martha S." last="Linet">Martha S. Linet</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name>
<affiliation><nlm:aff id="aff17">Department of Hematology, Hospices Civils de Lyon, Pierre benite Cedex 69495, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff18">Department of Hematology, Université Lyon-1, Pierre benite Cedex 69495, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff19">Laboratoire de Biologie Moléculaire de la Cellule UMR 5239, Centre National de la Recherche Scientifique, Pierre benite Cedex 69495, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lan, Qing" sort="Lan, Qing" uniqKey="Lan Q" first="Qing" last="Lan">Qing Lan</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation><nlm:aff id="aff20">Human Genetics Foundation, Turin 10126, Italy</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff21">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton, VIC 3010, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hjalgrim, Henrik" sort="Hjalgrim, Henrik" uniqKey="Hjalgrim H" first="Henrik" last="Hjalgrim">Henrik Hjalgrim</name>
<affiliation><nlm:aff id="aff23">Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name>
<affiliation><nlm:aff id="aff24">Department of Health Sciences, University of York, York YO10 5DD, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name>
<affiliation><nlm:aff id="aff23">Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff25">Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gu, Jian" sort="Gu, Jian" uniqKey="Gu J" first="Jian" last="Gu">Jian Gu</name>
<affiliation><nlm:aff id="aff26">Department of Epidemiology, M.D. Anderson Cancer Center, Houston, TX 77030, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ghesquieres, Herve" sort="Ghesquieres, Herve" uniqKey="Ghesquieres H" first="Hervé" last="Ghesquières">Hervé Ghesquières</name>
<affiliation><nlm:aff id="aff19">Laboratoire de Biologie Moléculaire de la Cellule UMR 5239, Centre National de la Recherche Scientifique, Pierre benite Cedex 69495, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff27">Department of Hematology, Centre Léon Bérard, Lyon 69008, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Link, Brian K" sort="Link, Brian K" uniqKey="Link B" first="Brian K." last="Link">Brian K. Link</name>
<affiliation><nlm:aff id="aff28">Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morton, Lindsay M" sort="Morton, Lindsay M" uniqKey="Morton L" first="Lindsay M." last="Morton">Lindsay M. Morton</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A." last="Holly">Elizabeth A. Holly</name>
<affiliation><nlm:aff id="aff11">Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA 94118, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smith, Alex" sort="Smith, Alex" uniqKey="Smith A" first="Alex" last="Smith">Alex Smith</name>
<affiliation><nlm:aff id="aff24">Department of Health Sciences, University of York, York YO10 5DD, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tinker, Lesley F" sort="Tinker, Lesley F" uniqKey="Tinker L" first="Lesley F." last="Tinker">Lesley F. Tinker</name>
<affiliation><nlm:aff id="aff29">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98117, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Teras, Lauren R" sort="Teras, Lauren R" uniqKey="Teras L" first="Lauren R." last="Teras">Lauren R. Teras</name>
<affiliation><nlm:aff id="aff30">Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kricker, Anne" sort="Kricker, Anne" uniqKey="Kricker A" first="Anne" last="Kricker">Anne Kricker</name>
<affiliation><nlm:aff id="aff31">Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Becker, Nikolaus" sort="Becker, Nikolaus" uniqKey="Becker N" first="Nikolaus" last="Becker">Nikolaus Becker</name>
<affiliation><nlm:aff id="aff32">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg 69120, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P." last="Purdue">Mark P. Purdue</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J." last="Spinelli">John J. Spinelli</name>
<affiliation><nlm:aff id="aff33">Cancer Control Research, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff34">School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhang, Yawei" sort="Zhang, Yawei" uniqKey="Zhang Y" first="Yawei" last="Zhang">Yawei Zhang</name>
<affiliation><nlm:aff id="aff35">Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation><nlm:aff id="aff21">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton, VIC 3010, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name>
<affiliation><nlm:aff id="aff20">Human Genetics Foundation, Turin 10126, Italy</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff36">MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Monnereau, Alain" sort="Monnereau, Alain" uniqKey="Monnereau A" first="Alain" last="Monnereau">Alain Monnereau</name>
<affiliation><nlm:aff id="aff37">Environmental Epidemiology of Cancer Group, Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Villejuif Cedex 94807, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff38">UMRS 1018, Université Paris Sud, Villejuif Cedex 94807, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff39">Registre des hémopathies malignes de la Gironde, Institut Bergonié, Bordeaux Cedex 33076, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bertrand, Kimberly A" sort="Bertrand, Kimberly A" uniqKey="Bertrand K" first="Kimberly A." last="Bertrand">Kimberly A. Bertrand</name>
<affiliation><nlm:aff id="aff8">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name>
<affiliation><nlm:aff id="aff41">Department of Population Health, New York University School of Medicine, New York, NY 10016, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff42">Cancer Institute, New York University School of Medicine, New York, NY 10016, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gabbas, Attilio" sort="Gabbas, Attilio" uniqKey="Gabbas A" first="Attilio" last="Gabbas">Attilio Gabbas</name>
<affiliation><nlm:aff id="aff43">Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chung, Charles C" sort="Chung, Charles C" uniqKey="Chung C" first="Charles C." last="Chung">Charles C. Chung</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Burdett, Laurie" sort="Burdett, Laurie" uniqKey="Burdett L" first="Laurie" last="Burdett">Laurie Burdett</name>
<affiliation><nlm:aff id="aff5">Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hutchinson, Amy" sort="Hutchinson, Amy" uniqKey="Hutchinson A" first="Amy" last="Hutchinson">Amy Hutchinson</name>
<affiliation><nlm:aff id="aff5">Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lawrence, Charles" sort="Lawrence, Charles" uniqKey="Lawrence C" first="Charles" last="Lawrence">Charles Lawrence</name>
<affiliation><nlm:aff id="aff44">Health Studies Sector, Westat, Rockville, MD 20850, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Montalvan, Rebecca" sort="Montalvan, Rebecca" uniqKey="Montalvan R" first="Rebecca" last="Montalvan">Rebecca Montalvan</name>
<affiliation><nlm:aff id="aff44">Health Studies Sector, Westat, Rockville, MD 20850, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff45">Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Huang, Jinyan" sort="Huang, Jinyan" uniqKey="Huang J" first="Jinyan" last="Huang">Jinyan Huang</name>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ma, Baoshan" sort="Ma, Baoshan" uniqKey="Ma B" first="Baoshan" last="Ma">Baoshan Ma</name>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff46">College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning Province 116026, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name>
<affiliation><nlm:aff id="aff10">Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Adami, Hans Olov" sort="Adami, Hans Olov" uniqKey="Adami H" first="Hans-Olov" last="Adami">Hans-Olov Adami</name>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff47">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name>
<affiliation><nlm:aff id="aff48">Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm 17176, Sweden</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff49">Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala 75105, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ye, Yuanqing" sort="Ye, Yuanqing" uniqKey="Ye Y" first="Yuanqing" last="Ye">Yuanqing Ye</name>
<affiliation><nlm:aff id="aff26">Department of Epidemiology, M.D. Anderson Cancer Center, Houston, TX 77030, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nowakowski, Grzegorz S" sort="Nowakowski, Grzegorz S" uniqKey="Nowakowski G" first="Grzegorz S." last="Nowakowski">Grzegorz S. Nowakowski</name>
<affiliation><nlm:aff id="aff13">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dogan, Ahmet" sort="Dogan, Ahmet" uniqKey="Dogan A" first="Ahmet" last="Dogan">Ahmet Dogan</name>
<affiliation><nlm:aff id="aff50">Departments of Laboratory Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thompson, Carrie A" sort="Thompson, Carrie A" uniqKey="Thompson C" first="Carrie A." last="Thompson">Carrie A. Thompson</name>
<affiliation><nlm:aff id="aff51">Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Habermann, Thomas M" sort="Habermann, Thomas M" uniqKey="Habermann T" first="Thomas M." last="Habermann">Thomas M. Habermann</name>
<affiliation><nlm:aff id="aff51">Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Novak, Anne J" sort="Novak, Anne J" uniqKey="Novak A" first="Anne J." last="Novak">Anne J. Novak</name>
<affiliation><nlm:aff id="aff51">Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liebow, Mark" sort="Liebow, Mark" uniqKey="Liebow M" first="Mark" last="Liebow">Mark Liebow</name>
<affiliation><nlm:aff id="aff51">Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Witzig, Thomas E" sort="Witzig, Thomas E" uniqKey="Witzig T" first="Thomas E." last="Witzig">Thomas E. Witzig</name>
<affiliation><nlm:aff id="aff51">Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Weiner, George J" sort="Weiner, George J" uniqKey="Weiner G" first="George J." last="Weiner">George J. Weiner</name>
<affiliation><nlm:aff id="aff28">Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schenk, Maryjean" sort="Schenk, Maryjean" uniqKey="Schenk M" first="Maryjean" last="Schenk">Maryjean Schenk</name>
<affiliation><nlm:aff id="aff52">Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI 48201, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Roos, Anneclaire J" sort="De Roos, Anneclaire J" uniqKey="De Roos A" first="Anneclaire J." last="De Roos">Anneclaire J. De Roos</name>
<affiliation><nlm:aff id="aff29">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98117, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff53">Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, PA 19104, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cozen, Wendy" sort="Cozen, Wendy" uniqKey="Cozen W" first="Wendy" last="Cozen">Wendy Cozen</name>
<affiliation><nlm:aff id="aff54">Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff55">Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhi, Degui" sort="Zhi, Degui" uniqKey="Zhi D" first="Degui" last="Zhi">Degui Zhi</name>
<affiliation><nlm:aff id="aff56">Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35233, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Akers, Nicholas K" sort="Akers, Nicholas K" uniqKey="Akers N" first="Nicholas K." last="Akers">Nicholas K. Akers</name>
<affiliation><nlm:aff id="aff2">Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Riby, Jacques" sort="Riby, Jacques" uniqKey="Riby J" first="Jacques" last="Riby">Jacques Riby</name>
<affiliation><nlm:aff id="aff1">Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, AL 35233, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smith, Martyn T" sort="Smith, Martyn T" uniqKey="Smith M" first="Martyn T." last="Smith">Martyn T. Smith</name>
<affiliation><nlm:aff id="aff2">Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lacher, Mortimer" sort="Lacher, Mortimer" uniqKey="Lacher M" first="Mortimer" last="Lacher">Mortimer Lacher</name>
<affiliation><nlm:aff id="aff4">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Villano, Danylo J" sort="Villano, Danylo J" uniqKey="Villano D" first="Danylo J." last="Villano">Danylo J. Villano</name>
<affiliation><nlm:aff id="aff4">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Maria, Ann" sort="Maria, Ann" uniqKey="Maria A" first="Ann" last="Maria">Ann Maria</name>
<affiliation><nlm:aff id="aff4">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name>
<affiliation><nlm:aff id="aff24">Department of Health Sciences, University of York, York YO10 5DD, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kane, Eleanor" sort="Kane, Eleanor" uniqKey="Kane E" first="Eleanor" last="Kane">Eleanor Kane</name>
<affiliation><nlm:aff id="aff24">Department of Health Sciences, University of York, York YO10 5DD, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jackson, Rebecca D" sort="Jackson, Rebecca D" uniqKey="Jackson R" first="Rebecca D." last="Jackson">Rebecca D. Jackson</name>
<affiliation><nlm:aff id="aff57">Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E." last="North">Kari E. North</name>
<affiliation><nlm:aff id="aff58">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff59">Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name>
<affiliation><nlm:aff id="aff30">Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Turner, Jenny" sort="Turner, Jenny" uniqKey="Turner J" first="Jenny" last="Turner">Jenny Turner</name>
<affiliation><nlm:aff id="aff60">Department of Anatomical Pathology, Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff61">Department of Histopathology, Douglass Hanly Moir Pathology, Macquarie Park, NSW 2113, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name>
<affiliation><nlm:aff id="aff31">Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Benavente, Yolanda" sort="Benavente, Yolanda" uniqKey="Benavente Y" first="Yolanda" last="Benavente">Yolanda Benavente</name>
<affiliation><nlm:aff id="aff14">Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d’Oncologia, IDIBELL, Barcelona 8907, Spain</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff15">Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona 8036, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name>
<affiliation><nlm:aff id="aff62">The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
<affiliation><nlm:aff id="aff63">Group of Genetic Epidemiology, Section of Genetics, International Agency for Research on Cancer, Lyon 69372, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name>
<affiliation><nlm:aff id="aff64">Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno 656 53, Czech Republic</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadie">Marc Maynadie</name>
<affiliation><nlm:aff id="aff65">EA 4184, Registre des Hémopathies Malignes de Côte d’Or, University of Burgundy and Dijon University Hospital, Dijon 21070, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Staines, Anthony" sort="Staines, Anthony" uniqKey="Staines A" first="Anthony" last="Staines">Anthony Staines</name>
<affiliation><nlm:aff id="aff66">School of Nursing and Human Sciences, Dublin City University, Dublin 9, Ireland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name>
<affiliation><nlm:aff id="aff67">Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer, Lyon 69372, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brooks Wilson, Angela R" sort="Brooks Wilson, Angela R" uniqKey="Brooks Wilson A" first="Angela R." last="Brooks-Wilson">Angela R. Brooks-Wilson</name>
<affiliation><nlm:aff id="aff68">Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff69">Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zheng, Tongzhang" sort="Zheng, Tongzhang" uniqKey="Zheng T" first="Tongzhang" last="Zheng">Tongzhang Zheng</name>
<affiliation><nlm:aff id="aff35">Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Holford, Theodore R" sort="Holford, Theodore R" uniqKey="Holford T" first="Theodore R." last="Holford">Theodore R. Holford</name>
<affiliation><nlm:aff id="aff70">Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chamosa, Saioa" sort="Chamosa, Saioa" uniqKey="Chamosa S" first="Saioa" last="Chamosa">Saioa Chamosa</name>
<affiliation><nlm:aff id="aff71">Health Department, BioDonostia Research Institute, Basque Region 20014, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolph" sort="Kaaks, Rudolph" uniqKey="Kaaks R" first="Rudolph" last="Kaaks">Rudolph Kaaks</name>
<affiliation><nlm:aff id="aff32">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg 69120, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kelly, Rachel S" sort="Kelly, Rachel S" uniqKey="Kelly R" first="Rachel S." last="Kelly">Rachel S. Kelly</name>
<affiliation><nlm:aff id="aff36">MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ohlsson, Bodil" sort="Ohlsson, Bodil" uniqKey="Ohlsson B" first="Bodil" last="Ohlsson">Bodil Ohlsson</name>
<affiliation><nlm:aff id="aff72">Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Lund University, Malmö 205 02, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name>
<affiliation><nlm:aff id="aff73">Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name>
<affiliation><nlm:aff id="aff47">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff74">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Breivika 9037, Norway</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff75">Cancer Registry of Norway, Oslo 0304, Norway</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff76">Department of Genetic Epidemiology, Folkhalsan Research Center, Helsinki 00250, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name>
<affiliation><nlm:aff id="aff37">Environmental Epidemiology of Cancer Group, Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Villejuif Cedex 94807, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff38">UMRS 1018, Université Paris Sud, Villejuif Cedex 94807, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name>
<affiliation><nlm:aff id="aff8">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff77">Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff45">Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name>
<affiliation><nlm:aff id="aff78">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki 00271, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mazza, Patrizio" sort="Mazza, Patrizio" uniqKey="Mazza P" first="Patrizio" last="Mazza">Patrizio Mazza</name>
<affiliation><nlm:aff id="aff79">Department of Hematology, Ospedale Nord, Taranto 74100, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name>
<affiliation><nlm:aff id="aff43">Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ennas, Maria Grazia" sort="Ennas, Maria Grazia" uniqKey="Ennas M" first="Maria Grazia" last="Ennas">Maria Grazia Ennas</name>
<affiliation><nlm:aff id="aff80">Department of Biomedical Science, University of Cagliari, Monserrato, Cagliari 09042, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chiu, Brian C H" sort="Chiu, Brian C H" uniqKey="Chiu B" first="Brian C. H." last="Chiu">Brian C. H. Chiu</name>
<affiliation><nlm:aff id="aff81">Department of Health Studies, University of Chicago, Chicago, IL 60637, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fraumeni, Joseph F" sort="Fraumeni, Joseph F" uniqKey="Fraumeni J" first="Joseph F." last="Fraumeni">Joseph F. Fraumeni</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nieters, Alexandra" sort="Nieters, Alexandra" uniqKey="Nieters A" first="Alexandra" last="Nieters">Alexandra Nieters</name>
<affiliation><nlm:aff id="aff82">Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Baden-Württemberg 79108, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name>
<affiliation><nlm:aff id="aff4">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name>
<affiliation><nlm:aff id="aff26">Department of Epidemiology, M.D. Anderson Cancer Center, Houston, TX 77030, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cerhan, James R" sort="Cerhan, James R" uniqKey="Cerhan J" first="James R." last="Cerhan">James R. Cerhan</name>
<affiliation><nlm:aff id="aff13">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smedby, Karin E" sort="Smedby, Karin E" uniqKey="Smedby K" first="Karin E." last="Smedby">Karin E. Smedby</name>
<affiliation><nlm:aff id="aff83">Department of Medicine Solna, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
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</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25279986</idno>
<idno type="pmc">4185120</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185120</idno>
<idno type="RBID">PMC:4185120</idno>
<idno type="doi">10.1016/j.ajhg.2014.09.004</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001210</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001210</idno>
</publicationStmt>
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<affiliation><nlm:aff id="aff1">Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, AL 35233, USA</nlm:aff>
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<affiliation><nlm:aff id="aff2">Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA</nlm:aff>
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<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
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<affiliation><nlm:aff id="aff4">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
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<affiliation><nlm:aff id="aff1">Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, AL 35233, USA</nlm:aff>
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<affiliation><nlm:aff id="aff2">Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA</nlm:aff>
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<affiliation><nlm:aff id="aff5">Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA</nlm:aff>
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<affiliation><nlm:aff id="aff5">Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA</nlm:aff>
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<affiliation><nlm:aff id="aff6">Department of Medical Genetics and of Epidemiology, University Medical Center Utrecht, Utrecht 3584 CG, the Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff7">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands</nlm:aff>
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<affiliation><nlm:aff id="aff8">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff>
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<affiliation><nlm:aff id="aff9">Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia</nlm:aff>
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<affiliation><nlm:aff id="aff10">Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff>
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<affiliation><nlm:aff id="aff11">Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA 94118, USA</nlm:aff>
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<affiliation><nlm:aff id="aff7">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff12">Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, the Netherlands</nlm:aff>
</affiliation>
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<author><name sortKey="Slager, Susan L" sort="Slager, Susan L" uniqKey="Slager S" first="Susan L." last="Slager">Susan L. Slager</name>
<affiliation><nlm:aff id="aff13">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
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<author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjose">Silvia De Sanjose</name>
<affiliation><nlm:aff id="aff14">Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d’Oncologia, IDIBELL, Barcelona 8907, Spain</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff15">Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona 8036, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Sophia S" sort="Wang, Sophia S" uniqKey="Wang S" first="Sophia S." last="Wang">Sophia S. Wang</name>
<affiliation><nlm:aff id="aff16">Department of Cancer Etiology, City of Hope Beckman Research Institute, Duarte, CA 91030, USA</nlm:aff>
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<author><name sortKey="Linet, Martha S" sort="Linet, Martha S" uniqKey="Linet M" first="Martha S." last="Linet">Martha S. Linet</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name>
<affiliation><nlm:aff id="aff17">Department of Hematology, Hospices Civils de Lyon, Pierre benite Cedex 69495, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff18">Department of Hematology, Université Lyon-1, Pierre benite Cedex 69495, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff19">Laboratoire de Biologie Moléculaire de la Cellule UMR 5239, Centre National de la Recherche Scientifique, Pierre benite Cedex 69495, France</nlm:aff>
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</author>
<author><name sortKey="Lan, Qing" sort="Lan, Qing" uniqKey="Lan Q" first="Qing" last="Lan">Qing Lan</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation><nlm:aff id="aff20">Human Genetics Foundation, Turin 10126, Italy</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff21">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton, VIC 3010, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hjalgrim, Henrik" sort="Hjalgrim, Henrik" uniqKey="Hjalgrim H" first="Henrik" last="Hjalgrim">Henrik Hjalgrim</name>
<affiliation><nlm:aff id="aff23">Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name>
<affiliation><nlm:aff id="aff24">Department of Health Sciences, University of York, York YO10 5DD, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name>
<affiliation><nlm:aff id="aff23">Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff25">Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gu, Jian" sort="Gu, Jian" uniqKey="Gu J" first="Jian" last="Gu">Jian Gu</name>
<affiliation><nlm:aff id="aff26">Department of Epidemiology, M.D. Anderson Cancer Center, Houston, TX 77030, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ghesquieres, Herve" sort="Ghesquieres, Herve" uniqKey="Ghesquieres H" first="Hervé" last="Ghesquières">Hervé Ghesquières</name>
<affiliation><nlm:aff id="aff19">Laboratoire de Biologie Moléculaire de la Cellule UMR 5239, Centre National de la Recherche Scientifique, Pierre benite Cedex 69495, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff27">Department of Hematology, Centre Léon Bérard, Lyon 69008, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Link, Brian K" sort="Link, Brian K" uniqKey="Link B" first="Brian K." last="Link">Brian K. Link</name>
<affiliation><nlm:aff id="aff28">Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morton, Lindsay M" sort="Morton, Lindsay M" uniqKey="Morton L" first="Lindsay M." last="Morton">Lindsay M. Morton</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A." last="Holly">Elizabeth A. Holly</name>
<affiliation><nlm:aff id="aff11">Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA 94118, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smith, Alex" sort="Smith, Alex" uniqKey="Smith A" first="Alex" last="Smith">Alex Smith</name>
<affiliation><nlm:aff id="aff24">Department of Health Sciences, University of York, York YO10 5DD, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tinker, Lesley F" sort="Tinker, Lesley F" uniqKey="Tinker L" first="Lesley F." last="Tinker">Lesley F. Tinker</name>
<affiliation><nlm:aff id="aff29">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98117, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Teras, Lauren R" sort="Teras, Lauren R" uniqKey="Teras L" first="Lauren R." last="Teras">Lauren R. Teras</name>
<affiliation><nlm:aff id="aff30">Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kricker, Anne" sort="Kricker, Anne" uniqKey="Kricker A" first="Anne" last="Kricker">Anne Kricker</name>
<affiliation><nlm:aff id="aff31">Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Becker, Nikolaus" sort="Becker, Nikolaus" uniqKey="Becker N" first="Nikolaus" last="Becker">Nikolaus Becker</name>
<affiliation><nlm:aff id="aff32">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg 69120, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P." last="Purdue">Mark P. Purdue</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J." last="Spinelli">John J. Spinelli</name>
<affiliation><nlm:aff id="aff33">Cancer Control Research, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff34">School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhang, Yawei" sort="Zhang, Yawei" uniqKey="Zhang Y" first="Yawei" last="Zhang">Yawei Zhang</name>
<affiliation><nlm:aff id="aff35">Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation><nlm:aff id="aff21">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton, VIC 3010, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name>
<affiliation><nlm:aff id="aff20">Human Genetics Foundation, Turin 10126, Italy</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff36">MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Monnereau, Alain" sort="Monnereau, Alain" uniqKey="Monnereau A" first="Alain" last="Monnereau">Alain Monnereau</name>
<affiliation><nlm:aff id="aff37">Environmental Epidemiology of Cancer Group, Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Villejuif Cedex 94807, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff38">UMRS 1018, Université Paris Sud, Villejuif Cedex 94807, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff39">Registre des hémopathies malignes de la Gironde, Institut Bergonié, Bordeaux Cedex 33076, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bertrand, Kimberly A" sort="Bertrand, Kimberly A" uniqKey="Bertrand K" first="Kimberly A." last="Bertrand">Kimberly A. Bertrand</name>
<affiliation><nlm:aff id="aff8">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name>
<affiliation><nlm:aff id="aff41">Department of Population Health, New York University School of Medicine, New York, NY 10016, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff42">Cancer Institute, New York University School of Medicine, New York, NY 10016, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gabbas, Attilio" sort="Gabbas, Attilio" uniqKey="Gabbas A" first="Attilio" last="Gabbas">Attilio Gabbas</name>
<affiliation><nlm:aff id="aff43">Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chung, Charles C" sort="Chung, Charles C" uniqKey="Chung C" first="Charles C." last="Chung">Charles C. Chung</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Burdett, Laurie" sort="Burdett, Laurie" uniqKey="Burdett L" first="Laurie" last="Burdett">Laurie Burdett</name>
<affiliation><nlm:aff id="aff5">Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hutchinson, Amy" sort="Hutchinson, Amy" uniqKey="Hutchinson A" first="Amy" last="Hutchinson">Amy Hutchinson</name>
<affiliation><nlm:aff id="aff5">Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lawrence, Charles" sort="Lawrence, Charles" uniqKey="Lawrence C" first="Charles" last="Lawrence">Charles Lawrence</name>
<affiliation><nlm:aff id="aff44">Health Studies Sector, Westat, Rockville, MD 20850, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Montalvan, Rebecca" sort="Montalvan, Rebecca" uniqKey="Montalvan R" first="Rebecca" last="Montalvan">Rebecca Montalvan</name>
<affiliation><nlm:aff id="aff44">Health Studies Sector, Westat, Rockville, MD 20850, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff45">Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Huang, Jinyan" sort="Huang, Jinyan" uniqKey="Huang J" first="Jinyan" last="Huang">Jinyan Huang</name>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ma, Baoshan" sort="Ma, Baoshan" uniqKey="Ma B" first="Baoshan" last="Ma">Baoshan Ma</name>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff46">College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning Province 116026, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name>
<affiliation><nlm:aff id="aff10">Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Adami, Hans Olov" sort="Adami, Hans Olov" uniqKey="Adami H" first="Hans-Olov" last="Adami">Hans-Olov Adami</name>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff47">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name>
<affiliation><nlm:aff id="aff48">Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm 17176, Sweden</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff49">Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala 75105, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ye, Yuanqing" sort="Ye, Yuanqing" uniqKey="Ye Y" first="Yuanqing" last="Ye">Yuanqing Ye</name>
<affiliation><nlm:aff id="aff26">Department of Epidemiology, M.D. Anderson Cancer Center, Houston, TX 77030, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nowakowski, Grzegorz S" sort="Nowakowski, Grzegorz S" uniqKey="Nowakowski G" first="Grzegorz S." last="Nowakowski">Grzegorz S. Nowakowski</name>
<affiliation><nlm:aff id="aff13">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dogan, Ahmet" sort="Dogan, Ahmet" uniqKey="Dogan A" first="Ahmet" last="Dogan">Ahmet Dogan</name>
<affiliation><nlm:aff id="aff50">Departments of Laboratory Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thompson, Carrie A" sort="Thompson, Carrie A" uniqKey="Thompson C" first="Carrie A." last="Thompson">Carrie A. Thompson</name>
<affiliation><nlm:aff id="aff51">Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Habermann, Thomas M" sort="Habermann, Thomas M" uniqKey="Habermann T" first="Thomas M." last="Habermann">Thomas M. Habermann</name>
<affiliation><nlm:aff id="aff51">Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Novak, Anne J" sort="Novak, Anne J" uniqKey="Novak A" first="Anne J." last="Novak">Anne J. Novak</name>
<affiliation><nlm:aff id="aff51">Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liebow, Mark" sort="Liebow, Mark" uniqKey="Liebow M" first="Mark" last="Liebow">Mark Liebow</name>
<affiliation><nlm:aff id="aff51">Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Witzig, Thomas E" sort="Witzig, Thomas E" uniqKey="Witzig T" first="Thomas E." last="Witzig">Thomas E. Witzig</name>
<affiliation><nlm:aff id="aff51">Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Weiner, George J" sort="Weiner, George J" uniqKey="Weiner G" first="George J." last="Weiner">George J. Weiner</name>
<affiliation><nlm:aff id="aff28">Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schenk, Maryjean" sort="Schenk, Maryjean" uniqKey="Schenk M" first="Maryjean" last="Schenk">Maryjean Schenk</name>
<affiliation><nlm:aff id="aff52">Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI 48201, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Roos, Anneclaire J" sort="De Roos, Anneclaire J" uniqKey="De Roos A" first="Anneclaire J." last="De Roos">Anneclaire J. De Roos</name>
<affiliation><nlm:aff id="aff29">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98117, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff53">Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, PA 19104, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cozen, Wendy" sort="Cozen, Wendy" uniqKey="Cozen W" first="Wendy" last="Cozen">Wendy Cozen</name>
<affiliation><nlm:aff id="aff54">Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff55">Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhi, Degui" sort="Zhi, Degui" uniqKey="Zhi D" first="Degui" last="Zhi">Degui Zhi</name>
<affiliation><nlm:aff id="aff56">Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35233, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Akers, Nicholas K" sort="Akers, Nicholas K" uniqKey="Akers N" first="Nicholas K." last="Akers">Nicholas K. Akers</name>
<affiliation><nlm:aff id="aff2">Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Riby, Jacques" sort="Riby, Jacques" uniqKey="Riby J" first="Jacques" last="Riby">Jacques Riby</name>
<affiliation><nlm:aff id="aff1">Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, AL 35233, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smith, Martyn T" sort="Smith, Martyn T" uniqKey="Smith M" first="Martyn T." last="Smith">Martyn T. Smith</name>
<affiliation><nlm:aff id="aff2">Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lacher, Mortimer" sort="Lacher, Mortimer" uniqKey="Lacher M" first="Mortimer" last="Lacher">Mortimer Lacher</name>
<affiliation><nlm:aff id="aff4">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Villano, Danylo J" sort="Villano, Danylo J" uniqKey="Villano D" first="Danylo J." last="Villano">Danylo J. Villano</name>
<affiliation><nlm:aff id="aff4">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Maria, Ann" sort="Maria, Ann" uniqKey="Maria A" first="Ann" last="Maria">Ann Maria</name>
<affiliation><nlm:aff id="aff4">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name>
<affiliation><nlm:aff id="aff24">Department of Health Sciences, University of York, York YO10 5DD, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kane, Eleanor" sort="Kane, Eleanor" uniqKey="Kane E" first="Eleanor" last="Kane">Eleanor Kane</name>
<affiliation><nlm:aff id="aff24">Department of Health Sciences, University of York, York YO10 5DD, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jackson, Rebecca D" sort="Jackson, Rebecca D" uniqKey="Jackson R" first="Rebecca D." last="Jackson">Rebecca D. Jackson</name>
<affiliation><nlm:aff id="aff57">Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E." last="North">Kari E. North</name>
<affiliation><nlm:aff id="aff58">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff59">Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name>
<affiliation><nlm:aff id="aff30">Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Turner, Jenny" sort="Turner, Jenny" uniqKey="Turner J" first="Jenny" last="Turner">Jenny Turner</name>
<affiliation><nlm:aff id="aff60">Department of Anatomical Pathology, Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff61">Department of Histopathology, Douglass Hanly Moir Pathology, Macquarie Park, NSW 2113, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name>
<affiliation><nlm:aff id="aff31">Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Benavente, Yolanda" sort="Benavente, Yolanda" uniqKey="Benavente Y" first="Yolanda" last="Benavente">Yolanda Benavente</name>
<affiliation><nlm:aff id="aff14">Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d’Oncologia, IDIBELL, Barcelona 8907, Spain</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff15">Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona 8036, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name>
<affiliation><nlm:aff id="aff62">The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
<affiliation><nlm:aff id="aff63">Group of Genetic Epidemiology, Section of Genetics, International Agency for Research on Cancer, Lyon 69372, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name>
<affiliation><nlm:aff id="aff64">Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno 656 53, Czech Republic</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadie">Marc Maynadie</name>
<affiliation><nlm:aff id="aff65">EA 4184, Registre des Hémopathies Malignes de Côte d’Or, University of Burgundy and Dijon University Hospital, Dijon 21070, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Staines, Anthony" sort="Staines, Anthony" uniqKey="Staines A" first="Anthony" last="Staines">Anthony Staines</name>
<affiliation><nlm:aff id="aff66">School of Nursing and Human Sciences, Dublin City University, Dublin 9, Ireland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name>
<affiliation><nlm:aff id="aff67">Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer, Lyon 69372, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brooks Wilson, Angela R" sort="Brooks Wilson, Angela R" uniqKey="Brooks Wilson A" first="Angela R." last="Brooks-Wilson">Angela R. Brooks-Wilson</name>
<affiliation><nlm:aff id="aff68">Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff69">Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zheng, Tongzhang" sort="Zheng, Tongzhang" uniqKey="Zheng T" first="Tongzhang" last="Zheng">Tongzhang Zheng</name>
<affiliation><nlm:aff id="aff35">Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Holford, Theodore R" sort="Holford, Theodore R" uniqKey="Holford T" first="Theodore R." last="Holford">Theodore R. Holford</name>
<affiliation><nlm:aff id="aff70">Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chamosa, Saioa" sort="Chamosa, Saioa" uniqKey="Chamosa S" first="Saioa" last="Chamosa">Saioa Chamosa</name>
<affiliation><nlm:aff id="aff71">Health Department, BioDonostia Research Institute, Basque Region 20014, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolph" sort="Kaaks, Rudolph" uniqKey="Kaaks R" first="Rudolph" last="Kaaks">Rudolph Kaaks</name>
<affiliation><nlm:aff id="aff32">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg 69120, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kelly, Rachel S" sort="Kelly, Rachel S" uniqKey="Kelly R" first="Rachel S." last="Kelly">Rachel S. Kelly</name>
<affiliation><nlm:aff id="aff36">MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ohlsson, Bodil" sort="Ohlsson, Bodil" uniqKey="Ohlsson B" first="Bodil" last="Ohlsson">Bodil Ohlsson</name>
<affiliation><nlm:aff id="aff72">Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Lund University, Malmö 205 02, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name>
<affiliation><nlm:aff id="aff73">Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name>
<affiliation><nlm:aff id="aff47">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff74">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Breivika 9037, Norway</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff75">Cancer Registry of Norway, Oslo 0304, Norway</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff76">Department of Genetic Epidemiology, Folkhalsan Research Center, Helsinki 00250, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name>
<affiliation><nlm:aff id="aff37">Environmental Epidemiology of Cancer Group, Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Villejuif Cedex 94807, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff38">UMRS 1018, Université Paris Sud, Villejuif Cedex 94807, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name>
<affiliation><nlm:aff id="aff8">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff77">Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation><nlm:aff id="aff40">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff45">Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name>
<affiliation><nlm:aff id="aff78">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki 00271, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mazza, Patrizio" sort="Mazza, Patrizio" uniqKey="Mazza P" first="Patrizio" last="Mazza">Patrizio Mazza</name>
<affiliation><nlm:aff id="aff79">Department of Hematology, Ospedale Nord, Taranto 74100, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name>
<affiliation><nlm:aff id="aff43">Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ennas, Maria Grazia" sort="Ennas, Maria Grazia" uniqKey="Ennas M" first="Maria Grazia" last="Ennas">Maria Grazia Ennas</name>
<affiliation><nlm:aff id="aff80">Department of Biomedical Science, University of Cagliari, Monserrato, Cagliari 09042, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chiu, Brian C H" sort="Chiu, Brian C H" uniqKey="Chiu B" first="Brian C. H." last="Chiu">Brian C. H. Chiu</name>
<affiliation><nlm:aff id="aff81">Department of Health Studies, University of Chicago, Chicago, IL 60637, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fraumeni, Joseph F" sort="Fraumeni, Joseph F" uniqKey="Fraumeni J" first="Joseph F." last="Fraumeni">Joseph F. Fraumeni</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nieters, Alexandra" sort="Nieters, Alexandra" uniqKey="Nieters A" first="Alexandra" last="Nieters">Alexandra Nieters</name>
<affiliation><nlm:aff id="aff82">Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Baden-Württemberg 79108, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name>
<affiliation><nlm:aff id="aff4">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name>
<affiliation><nlm:aff id="aff26">Department of Epidemiology, M.D. Anderson Cancer Center, Houston, TX 77030, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cerhan, James R" sort="Cerhan, James R" uniqKey="Cerhan J" first="James R." last="Cerhan">James R. Cerhan</name>
<affiliation><nlm:aff id="aff13">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smedby, Karin E" sort="Smedby, Karin E" uniqKey="Smedby K" first="Karin E." last="Smedby">Karin E. Smedby</name>
<affiliation><nlm:aff id="aff83">Department of Medicine Solna, Karolinska Institutet, Stockholm 17176, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name>
<affiliation><nlm:aff id="aff3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">American Journal of Human Genetics</title>
<idno type="ISSN">0002-9297</idno>
<idno type="eISSN">1537-6605</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10<sup>−20</sup>
) near <italic>CXCR5</italic>
; 11q24.3 (rs4937362, p = 6.76 × 10<sup>−11</sup>
) near <italic>ETS1</italic>
; 3q28 (rs6444305, p = 1.10 × 10<sup>−10</sup>
) in <italic>LPP</italic>
; 18q21.33 (rs17749561, p = 8.28 × 10<sup>−10</sup>
) near <italic>BCL2</italic>
; and 8q24.21 (rs13254990, p = 1.06 × 10<sup>−8</sup>
) near <italic>PVT1</italic>
. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (p<sub>omnibus</sub>
= 4.20 × 10<sup>−67</sup>
to 2.67 × 10<sup>−70</sup>
). Additional independent signals included rs17203612 in HLA class II (odds ratio [OR<sub>per-allele</sub>
] = 1.44; p = 4.59 × 10<sup>−16</sup>
) and rs3130437 in HLA class I (OR<sub>per-allele</sub>
= 1.23; p = 8.23 × 10<sup>−9</sup>
). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.</p>
</div>
</front>
</TEI>
<pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Hum Genet</journal-id>
<journal-id journal-id-type="iso-abbrev">Am. J. Hum. Genet</journal-id>
<journal-title-group><journal-title>American Journal of Human Genetics</journal-title>
</journal-title-group>
<issn pub-type="ppub">0002-9297</issn>
<issn pub-type="epub">1537-6605</issn>
<publisher><publisher-name>Elsevier</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25279986</article-id>
<article-id pub-id-type="pmc">4185120</article-id>
<article-id pub-id-type="publisher-id">S0002-9297(14)00387-5</article-id>
<article-id pub-id-type="doi">10.1016/j.ajhg.2014.09.004</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Skibola</surname>
<given-names>Christine F.</given-names>
</name>
<email>cskibola@uab.edu</email>
<xref rid="aff1" ref-type="aff">1</xref>
<xref rid="aff2" ref-type="aff">2</xref>
<xref rid="fn1" ref-type="fn">84</xref>
<xref rid="cor1" ref-type="corresp">∗</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Berndt</surname>
<given-names>Sonja I.</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
<xref rid="fn1" ref-type="fn">84</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vijai</surname>
<given-names>Joseph</given-names>
</name>
<xref rid="aff4" ref-type="aff">4</xref>
<xref rid="fn1" ref-type="fn">84</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Conde</surname>
<given-names>Lucia</given-names>
</name>
<xref rid="aff1" ref-type="aff">1</xref>
<xref rid="aff2" ref-type="aff">2</xref>
<xref rid="fn1" ref-type="fn">84</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Zhaoming</given-names>
</name>
<xref rid="aff5" ref-type="aff">5</xref>
<xref rid="fn1" ref-type="fn">84</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yeager</surname>
<given-names>Meredith</given-names>
</name>
<xref rid="aff5" ref-type="aff">5</xref>
<xref rid="fn1" ref-type="fn">84</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Bakker</surname>
<given-names>Paul I.W.</given-names>
</name>
<xref rid="aff6" ref-type="aff">6</xref>
<xref rid="aff7" ref-type="aff">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Birmann</surname>
<given-names>Brenda M.</given-names>
</name>
<xref rid="aff8" ref-type="aff">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vajdic</surname>
<given-names>Claire M.</given-names>
</name>
<xref rid="aff9" ref-type="aff">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Foo</surname>
<given-names>Jia-Nee</given-names>
</name>
<xref rid="aff10" ref-type="aff">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bracci</surname>
<given-names>Paige M.</given-names>
</name>
<xref rid="aff11" ref-type="aff">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vermeulen</surname>
<given-names>Roel C.H.</given-names>
</name>
<xref rid="aff7" ref-type="aff">7</xref>
<xref rid="aff12" ref-type="aff">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Slager</surname>
<given-names>Susan L.</given-names>
</name>
<xref rid="aff13" ref-type="aff">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Sanjose</surname>
<given-names>Silvia</given-names>
</name>
<xref rid="aff14" ref-type="aff">14</xref>
<xref rid="aff15" ref-type="aff">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Sophia S.</given-names>
</name>
<xref rid="aff16" ref-type="aff">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Linet</surname>
<given-names>Martha S.</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Salles</surname>
<given-names>Gilles</given-names>
</name>
<xref rid="aff17" ref-type="aff">17</xref>
<xref rid="aff18" ref-type="aff">18</xref>
<xref rid="aff19" ref-type="aff">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lan</surname>
<given-names>Qing</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Severi</surname>
<given-names>Gianluca</given-names>
</name>
<xref rid="aff20" ref-type="aff">20</xref>
<xref rid="aff21" ref-type="aff">21</xref>
<xref rid="aff22" ref-type="aff">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hjalgrim</surname>
<given-names>Henrik</given-names>
</name>
<xref rid="aff23" ref-type="aff">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lightfoot</surname>
<given-names>Tracy</given-names>
</name>
<xref rid="aff24" ref-type="aff">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Melbye</surname>
<given-names>Mads</given-names>
</name>
<xref rid="aff23" ref-type="aff">23</xref>
<xref rid="aff25" ref-type="aff">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gu</surname>
<given-names>Jian</given-names>
</name>
<xref rid="aff26" ref-type="aff">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ghesquières</surname>
<given-names>Hervé</given-names>
</name>
<xref rid="aff19" ref-type="aff">19</xref>
<xref rid="aff27" ref-type="aff">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Link</surname>
<given-names>Brian K.</given-names>
</name>
<xref rid="aff28" ref-type="aff">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Morton</surname>
<given-names>Lindsay M.</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Holly</surname>
<given-names>Elizabeth A.</given-names>
</name>
<xref rid="aff11" ref-type="aff">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smith</surname>
<given-names>Alex</given-names>
</name>
<xref rid="aff24" ref-type="aff">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tinker</surname>
<given-names>Lesley F.</given-names>
</name>
<xref rid="aff29" ref-type="aff">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Teras</surname>
<given-names>Lauren R.</given-names>
</name>
<xref rid="aff30" ref-type="aff">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kricker</surname>
<given-names>Anne</given-names>
</name>
<xref rid="aff31" ref-type="aff">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Becker</surname>
<given-names>Nikolaus</given-names>
</name>
<xref rid="aff32" ref-type="aff">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Purdue</surname>
<given-names>Mark P.</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spinelli</surname>
<given-names>John J.</given-names>
</name>
<xref rid="aff33" ref-type="aff">33</xref>
<xref rid="aff34" ref-type="aff">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Yawei</given-names>
</name>
<xref rid="aff35" ref-type="aff">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giles</surname>
<given-names>Graham G.</given-names>
</name>
<xref rid="aff21" ref-type="aff">21</xref>
<xref rid="aff22" ref-type="aff">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vineis</surname>
<given-names>Paolo</given-names>
</name>
<xref rid="aff20" ref-type="aff">20</xref>
<xref rid="aff36" ref-type="aff">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Monnereau</surname>
<given-names>Alain</given-names>
</name>
<xref rid="aff37" ref-type="aff">37</xref>
<xref rid="aff38" ref-type="aff">38</xref>
<xref rid="aff39" ref-type="aff">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bertrand</surname>
<given-names>Kimberly A.</given-names>
</name>
<xref rid="aff8" ref-type="aff">8</xref>
<xref rid="aff40" ref-type="aff">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Albanes</surname>
<given-names>Demetrius</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zeleniuch-Jacquotte</surname>
<given-names>Anne</given-names>
</name>
<xref rid="aff41" ref-type="aff">41</xref>
<xref rid="aff42" ref-type="aff">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gabbas</surname>
<given-names>Attilio</given-names>
</name>
<xref rid="aff43" ref-type="aff">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chung</surname>
<given-names>Charles C.</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Burdett</surname>
<given-names>Laurie</given-names>
</name>
<xref rid="aff5" ref-type="aff">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hutchinson</surname>
<given-names>Amy</given-names>
</name>
<xref rid="aff5" ref-type="aff">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lawrence</surname>
<given-names>Charles</given-names>
</name>
<xref rid="aff44" ref-type="aff">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Montalvan</surname>
<given-names>Rebecca</given-names>
</name>
<xref rid="aff44" ref-type="aff">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liang</surname>
<given-names>Liming</given-names>
</name>
<xref rid="aff40" ref-type="aff">40</xref>
<xref rid="aff45" ref-type="aff">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huang</surname>
<given-names>Jinyan</given-names>
</name>
<xref rid="aff40" ref-type="aff">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ma</surname>
<given-names>Baoshan</given-names>
</name>
<xref rid="aff40" ref-type="aff">40</xref>
<xref rid="aff46" ref-type="aff">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Jianjun</given-names>
</name>
<xref rid="aff10" ref-type="aff">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Adami</surname>
<given-names>Hans-Olov</given-names>
</name>
<xref rid="aff40" ref-type="aff">40</xref>
<xref rid="aff47" ref-type="aff">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Glimelius</surname>
<given-names>Bengt</given-names>
</name>
<xref rid="aff48" ref-type="aff">48</xref>
<xref rid="aff49" ref-type="aff">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ye</surname>
<given-names>Yuanqing</given-names>
</name>
<xref rid="aff26" ref-type="aff">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nowakowski</surname>
<given-names>Grzegorz S.</given-names>
</name>
<xref rid="aff13" ref-type="aff">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dogan</surname>
<given-names>Ahmet</given-names>
</name>
<xref rid="aff50" ref-type="aff">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thompson</surname>
<given-names>Carrie A.</given-names>
</name>
<xref rid="aff51" ref-type="aff">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Habermann</surname>
<given-names>Thomas M.</given-names>
</name>
<xref rid="aff51" ref-type="aff">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Novak</surname>
<given-names>Anne J.</given-names>
</name>
<xref rid="aff51" ref-type="aff">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liebow</surname>
<given-names>Mark</given-names>
</name>
<xref rid="aff51" ref-type="aff">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Witzig</surname>
<given-names>Thomas E.</given-names>
</name>
<xref rid="aff51" ref-type="aff">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weiner</surname>
<given-names>George J.</given-names>
</name>
<xref rid="aff28" ref-type="aff">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schenk</surname>
<given-names>Maryjean</given-names>
</name>
<xref rid="aff52" ref-type="aff">52</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hartge</surname>
<given-names>Patricia</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>De Roos</surname>
<given-names>Anneclaire J.</given-names>
</name>
<xref rid="aff29" ref-type="aff">29</xref>
<xref rid="aff53" ref-type="aff">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cozen</surname>
<given-names>Wendy</given-names>
</name>
<xref rid="aff54" ref-type="aff">54</xref>
<xref rid="aff55" ref-type="aff">55</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhi</surname>
<given-names>Degui</given-names>
</name>
<xref rid="aff56" ref-type="aff">56</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Akers</surname>
<given-names>Nicholas K.</given-names>
</name>
<xref rid="aff2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Riby</surname>
<given-names>Jacques</given-names>
</name>
<xref rid="aff1" ref-type="aff">1</xref>
<xref rid="aff2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smith</surname>
<given-names>Martyn T.</given-names>
</name>
<xref rid="aff2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lacher</surname>
<given-names>Mortimer</given-names>
</name>
<xref rid="aff4" ref-type="aff">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Villano</surname>
<given-names>Danylo J.</given-names>
</name>
<xref rid="aff4" ref-type="aff">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Maria</surname>
<given-names>Ann</given-names>
</name>
<xref rid="aff4" ref-type="aff">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Roman</surname>
<given-names>Eve</given-names>
</name>
<xref rid="aff24" ref-type="aff">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kane</surname>
<given-names>Eleanor</given-names>
</name>
<xref rid="aff24" ref-type="aff">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jackson</surname>
<given-names>Rebecca D.</given-names>
</name>
<xref rid="aff57" ref-type="aff">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>North</surname>
<given-names>Kari E.</given-names>
</name>
<xref rid="aff58" ref-type="aff">58</xref>
<xref rid="aff59" ref-type="aff">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Diver</surname>
<given-names>W. Ryan</given-names>
</name>
<xref rid="aff30" ref-type="aff">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Turner</surname>
<given-names>Jenny</given-names>
</name>
<xref rid="aff60" ref-type="aff">60</xref>
<xref rid="aff61" ref-type="aff">61</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Armstrong</surname>
<given-names>Bruce K.</given-names>
</name>
<xref rid="aff31" ref-type="aff">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Benavente</surname>
<given-names>Yolanda</given-names>
</name>
<xref rid="aff14" ref-type="aff">14</xref>
<xref rid="aff15" ref-type="aff">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Boffetta</surname>
<given-names>Paolo</given-names>
</name>
<xref rid="aff62" ref-type="aff">62</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brennan</surname>
<given-names>Paul</given-names>
</name>
<xref rid="aff63" ref-type="aff">63</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Foretova</surname>
<given-names>Lenka</given-names>
</name>
<xref rid="aff64" ref-type="aff">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Maynadie</surname>
<given-names>Marc</given-names>
</name>
<xref rid="aff65" ref-type="aff">65</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Staines</surname>
<given-names>Anthony</given-names>
</name>
<xref rid="aff66" ref-type="aff">66</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McKay</surname>
<given-names>James</given-names>
</name>
<xref rid="aff67" ref-type="aff">67</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brooks-Wilson</surname>
<given-names>Angela R.</given-names>
</name>
<xref rid="aff68" ref-type="aff">68</xref>
<xref rid="aff69" ref-type="aff">69</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zheng</surname>
<given-names>Tongzhang</given-names>
</name>
<xref rid="aff35" ref-type="aff">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Holford</surname>
<given-names>Theodore R.</given-names>
</name>
<xref rid="aff70" ref-type="aff">70</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chamosa</surname>
<given-names>Saioa</given-names>
</name>
<xref rid="aff71" ref-type="aff">71</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kaaks</surname>
<given-names>Rudolph</given-names>
</name>
<xref rid="aff32" ref-type="aff">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kelly</surname>
<given-names>Rachel S.</given-names>
</name>
<xref rid="aff36" ref-type="aff">36</xref>
<xref rid="aff40" ref-type="aff">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ohlsson</surname>
<given-names>Bodil</given-names>
</name>
<xref rid="aff72" ref-type="aff">72</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Travis</surname>
<given-names>Ruth C.</given-names>
</name>
<xref rid="aff73" ref-type="aff">73</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weiderpass</surname>
<given-names>Elisabete</given-names>
</name>
<xref rid="aff47" ref-type="aff">47</xref>
<xref rid="aff74" ref-type="aff">74</xref>
<xref rid="aff75" ref-type="aff">75</xref>
<xref rid="aff76" ref-type="aff">76</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Clavel</surname>
<given-names>Jacqueline</given-names>
</name>
<xref rid="aff37" ref-type="aff">37</xref>
<xref rid="aff38" ref-type="aff">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giovannucci</surname>
<given-names>Edward</given-names>
</name>
<xref rid="aff8" ref-type="aff">8</xref>
<xref rid="aff40" ref-type="aff">40</xref>
<xref rid="aff77" ref-type="aff">77</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kraft</surname>
<given-names>Peter</given-names>
</name>
<xref rid="aff40" ref-type="aff">40</xref>
<xref rid="aff45" ref-type="aff">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Virtamo</surname>
<given-names>Jarmo</given-names>
</name>
<xref rid="aff78" ref-type="aff">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mazza</surname>
<given-names>Patrizio</given-names>
</name>
<xref rid="aff79" ref-type="aff">79</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cocco</surname>
<given-names>Pierluigi</given-names>
</name>
<xref rid="aff43" ref-type="aff">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ennas</surname>
<given-names>Maria Grazia</given-names>
</name>
<xref rid="aff80" ref-type="aff">80</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chiu</surname>
<given-names>Brian C.H.</given-names>
</name>
<xref rid="aff81" ref-type="aff">81</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fraumeni</surname>
<given-names>Joseph F.</given-names>
<suffix>Jr.</suffix>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nieters</surname>
<given-names>Alexandra</given-names>
</name>
<xref rid="aff82" ref-type="aff">82</xref>
<xref rid="fn2" ref-type="fn">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Offit</surname>
<given-names>Kenneth</given-names>
</name>
<xref rid="aff4" ref-type="aff">4</xref>
<xref rid="fn2" ref-type="fn">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wu</surname>
<given-names>Xifeng</given-names>
</name>
<xref rid="aff26" ref-type="aff">26</xref>
<xref rid="fn2" ref-type="fn">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cerhan</surname>
<given-names>James R.</given-names>
</name>
<xref rid="aff13" ref-type="aff">13</xref>
<xref rid="fn2" ref-type="fn">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smedby</surname>
<given-names>Karin E.</given-names>
</name>
<xref rid="aff83" ref-type="aff">83</xref>
<xref rid="fn2" ref-type="fn">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chanock</surname>
<given-names>Stephen J.</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
<xref rid="fn2" ref-type="fn">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rothman</surname>
<given-names>Nathaniel</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
<xref rid="fn2" ref-type="fn">85</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, AL 35233, USA</aff>
<aff id="aff2"><label>2</label>
Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA</aff>
<aff id="aff3"><label>3</label>
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA</aff>
<aff id="aff4"><label>4</label>
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</aff>
<aff id="aff5"><label>5</label>
Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA</aff>
<aff id="aff6"><label>6</label>
Department of Medical Genetics and of Epidemiology, University Medical Center Utrecht, Utrecht 3584 CG, the Netherlands</aff>
<aff id="aff7"><label>7</label>
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands</aff>
<aff id="aff8"><label>8</label>
Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</aff>
<aff id="aff9"><label>9</label>
Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia</aff>
<aff id="aff10"><label>10</label>
Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore</aff>
<aff id="aff11"><label>11</label>
Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA 94118, USA</aff>
<aff id="aff12"><label>12</label>
Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, the Netherlands</aff>
<aff id="aff13"><label>13</label>
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</aff>
<aff id="aff14"><label>14</label>
Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d’Oncologia, IDIBELL, Barcelona 8907, Spain</aff>
<aff id="aff15"><label>15</label>
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona 8036, Spain</aff>
<aff id="aff16"><label>16</label>
Department of Cancer Etiology, City of Hope Beckman Research Institute, Duarte, CA 91030, USA</aff>
<aff id="aff17"><label>17</label>
Department of Hematology, Hospices Civils de Lyon, Pierre benite Cedex 69495, France</aff>
<aff id="aff18"><label>18</label>
Department of Hematology, Université Lyon-1, Pierre benite Cedex 69495, France</aff>
<aff id="aff19"><label>19</label>
Laboratoire de Biologie Moléculaire de la Cellule UMR 5239, Centre National de la Recherche Scientifique, Pierre benite Cedex 69495, France</aff>
<aff id="aff20"><label>20</label>
Human Genetics Foundation, Turin 10126, Italy</aff>
<aff id="aff21"><label>21</label>
Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</aff>
<aff id="aff22"><label>22</label>
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton, VIC 3010, Australia</aff>
<aff id="aff23"><label>23</label>
Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark</aff>
<aff id="aff24"><label>24</label>
Department of Health Sciences, University of York, York YO10 5DD, UK</aff>
<aff id="aff25"><label>25</label>
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA</aff>
<aff id="aff26"><label>26</label>
Department of Epidemiology, M.D. Anderson Cancer Center, Houston, TX 77030, USA</aff>
<aff id="aff27"><label>27</label>
Department of Hematology, Centre Léon Bérard, Lyon 69008, France</aff>
<aff id="aff28"><label>28</label>
Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA</aff>
<aff id="aff29"><label>29</label>
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98117, USA</aff>
<aff id="aff30"><label>30</label>
Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA</aff>
<aff id="aff31"><label>31</label>
Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia</aff>
<aff id="aff32"><label>32</label>
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg 69120, Germany</aff>
<aff id="aff33"><label>33</label>
Cancer Control Research, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada</aff>
<aff id="aff34"><label>34</label>
School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada</aff>
<aff id="aff35"><label>35</label>
Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA</aff>
<aff id="aff36"><label>36</label>
MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK</aff>
<aff id="aff37"><label>37</label>
Environmental Epidemiology of Cancer Group, Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Villejuif Cedex 94807, France</aff>
<aff id="aff38"><label>38</label>
UMRS 1018, Université Paris Sud, Villejuif Cedex 94807, France</aff>
<aff id="aff39"><label>39</label>
Registre des hémopathies malignes de la Gironde, Institut Bergonié, Bordeaux Cedex 33076, France</aff>
<aff id="aff40"><label>40</label>
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</aff>
<aff id="aff41"><label>41</label>
Department of Population Health, New York University School of Medicine, New York, NY 10016, USA</aff>
<aff id="aff42"><label>42</label>
Cancer Institute, New York University School of Medicine, New York, NY 10016, USA</aff>
<aff id="aff43"><label>43</label>
Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy</aff>
<aff id="aff44"><label>44</label>
Health Studies Sector, Westat, Rockville, MD 20850, USA</aff>
<aff id="aff45"><label>45</label>
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA</aff>
<aff id="aff46"><label>46</label>
College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning Province 116026, China</aff>
<aff id="aff47"><label>47</label>
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</aff>
<aff id="aff48"><label>48</label>
Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm 17176, Sweden</aff>
<aff id="aff49"><label>49</label>
Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala 75105, Sweden</aff>
<aff id="aff50"><label>50</label>
Departments of Laboratory Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</aff>
<aff id="aff51"><label>51</label>
Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA</aff>
<aff id="aff52"><label>52</label>
Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI 48201, USA</aff>
<aff id="aff53"><label>53</label>
Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, PA 19104, USA</aff>
<aff id="aff54"><label>54</label>
Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</aff>
<aff id="aff55"><label>55</label>
Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</aff>
<aff id="aff56"><label>56</label>
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35233, USA</aff>
<aff id="aff57"><label>57</label>
Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH 43210, USA</aff>
<aff id="aff58"><label>58</label>
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</aff>
<aff id="aff59"><label>59</label>
Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</aff>
<aff id="aff60"><label>60</label>
Department of Anatomical Pathology, Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia</aff>
<aff id="aff61"><label>61</label>
Department of Histopathology, Douglass Hanly Moir Pathology, Macquarie Park, NSW 2113, Australia</aff>
<aff id="aff62"><label>62</label>
The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</aff>
<aff id="aff63"><label>63</label>
Group of Genetic Epidemiology, Section of Genetics, International Agency for Research on Cancer, Lyon 69372, France</aff>
<aff id="aff64"><label>64</label>
Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno 656 53, Czech Republic</aff>
<aff id="aff65"><label>65</label>
EA 4184, Registre des Hémopathies Malignes de Côte d’Or, University of Burgundy and Dijon University Hospital, Dijon 21070, France</aff>
<aff id="aff66"><label>66</label>
School of Nursing and Human Sciences, Dublin City University, Dublin 9, Ireland</aff>
<aff id="aff67"><label>67</label>
Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer, Lyon 69372, France</aff>
<aff id="aff68"><label>68</label>
Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada</aff>
<aff id="aff69"><label>69</label>
Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada</aff>
<aff id="aff70"><label>70</label>
Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA</aff>
<aff id="aff71"><label>71</label>
Health Department, BioDonostia Research Institute, Basque Region 20014, Spain</aff>
<aff id="aff72"><label>72</label>
Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Lund University, Malmö 205 02, Sweden</aff>
<aff id="aff73"><label>73</label>
Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK</aff>
<aff id="aff74"><label>74</label>
Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Breivika 9037, Norway</aff>
<aff id="aff75"><label>75</label>
Cancer Registry of Norway, Oslo 0304, Norway</aff>
<aff id="aff76"><label>76</label>
Department of Genetic Epidemiology, Folkhalsan Research Center, Helsinki 00250, Finland</aff>
<aff id="aff77"><label>77</label>
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA</aff>
<aff id="aff78"><label>78</label>
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki 00271, Finland</aff>
<aff id="aff79"><label>79</label>
Department of Hematology, Ospedale Nord, Taranto 74100, Italy</aff>
<aff id="aff80"><label>80</label>
Department of Biomedical Science, University of Cagliari, Monserrato, Cagliari 09042, Italy</aff>
<aff id="aff81"><label>81</label>
Department of Health Studies, University of Chicago, Chicago, IL 60637, USA</aff>
<aff id="aff82"><label>82</label>
Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Baden-Württemberg 79108, Germany</aff>
<aff id="aff83"><label>83</label>
Department of Medicine Solna, Karolinska Institutet, Stockholm 17176, Sweden</aff>
<author-notes><corresp id="cor1"><label>∗</label>
Corresponding author <email>cskibola@uab.edu</email>
</corresp>
<fn id="fn1"><label>84</label>
<p>These authors contributed equally to this work</p>
</fn>
<fn id="fn2"><label>85</label>
<p>These authors contributed equally to this work in a supervisory role</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>02</day>
<month>10</month>
<year>2014</year>
</pub-date>
<volume>95</volume>
<issue>4</issue>
<fpage>462</fpage>
<lpage>471</lpage>
<history><date date-type="received"><day>17</day>
<month>7</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>10</day>
<month>9</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© 2014 The American Society of Human Genetics. Published by Elsevier Ltd. All right reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
<copyright-holder>The American Society of Human Genetics</copyright-holder>
</permissions>
<abstract><p>Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10<sup>−20</sup>
) near <italic>CXCR5</italic>
; 11q24.3 (rs4937362, p = 6.76 × 10<sup>−11</sup>
) near <italic>ETS1</italic>
; 3q28 (rs6444305, p = 1.10 × 10<sup>−10</sup>
) in <italic>LPP</italic>
; 18q21.33 (rs17749561, p = 8.28 × 10<sup>−10</sup>
) near <italic>BCL2</italic>
; and 8q24.21 (rs13254990, p = 1.06 × 10<sup>−8</sup>
) near <italic>PVT1</italic>
. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (p<sub>omnibus</sub>
= 4.20 × 10<sup>−67</sup>
to 2.67 × 10<sup>−70</sup>
). Additional independent signals included rs17203612 in HLA class II (odds ratio [OR<sub>per-allele</sub>
] = 1.44; p = 4.59 × 10<sup>−16</sup>
) and rs3130437 in HLA class I (OR<sub>per-allele</sub>
= 1.23; p = 8.23 × 10<sup>−9</sup>
). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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