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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder</title><author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation><nlm:aff id="aff1">Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, D-52425 Juelich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Degenhardt, Franziska A" sort="Degenhardt, Franziska A" uniqKey="Degenhardt F" first="Franziska A." last="Degenhardt">Franziska A. Degenhardt</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Institute of Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Mir, Xavier" sort="Mir, Xavier" uniqKey="Mir X" first="Xavier" last="Mir">Xavier Mir</name><affiliation><nlm:aff id="aff5">Institute of Molecular Psychiatry, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Strohmaier, Jana" sort="Strohmaier, Jana" uniqKey="Strohmaier J" first="Jana" last="Strohmaier">Jana Strohmaier</name><affiliation><nlm:aff id="aff6">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Mannheim, D-68159 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Steffens, Michael" sort="Steffens, Michael" uniqKey="Steffens M" first="Michael" last="Steffens">Michael Steffens</name><affiliation><nlm:aff id="aff4">Institute of Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Meesters, Christian" sort="Meesters, Christian" uniqKey="Meesters C" first="Christian" last="Meesters">Christian Meesters</name><affiliation><nlm:aff id="aff4">Institute of Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Weingarten, Moritz" sort="Weingarten, Moritz" uniqKey="Weingarten M" first="Moritz" last="Weingarten">Moritz Weingarten</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Priebe, Lutz" sort="Priebe, Lutz" uniqKey="Priebe L" first="Lutz" last="Priebe">Lutz Priebe</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Haenisch, Britta" sort="Haenisch, Britta" uniqKey="Haenisch B" first="Britta" last="Haenisch">Britta Haenisch</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Alexander, Michael" sort="Alexander, Michael" uniqKey="Alexander M" first="Michael" last="Alexander">Michael Alexander</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Vollmer, Jennifer" sort="Vollmer, Jennifer" uniqKey="Vollmer J" first="Jennifer" last="Vollmer">Jennifer Vollmer</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Breuer, Rene" sort="Breuer, Rene" uniqKey="Breuer R" first="René" last="Breuer">René Breuer</name><affiliation><nlm:aff id="aff6">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Mannheim, D-68159 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Schm L, Christine" sort="Schm L, Christine" uniqKey="Schm L C" first="Christine" last="Schm L">Christine Schm L</name><affiliation><nlm:aff id="aff6">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Mannheim, D-68159 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Tessmann, Peter" sort="Tessmann, Peter" uniqKey="Tessmann P" first="Peter" last="Tessmann">Peter Tessmann</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation><nlm:aff id="aff7">Institute of Medical Informatics, Biometry, and Epidemiology, University Duisburg-Essen, D-45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation><nlm:aff id="aff8">Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff9">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Klinikum Grosshadern, D-81377 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation><nlm:aff id="aff11">Institute of Clinical Molecular Biology, University of Kiel, D-24105 Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation><nlm:aff id="aff12">Max-Planck-Institute of Psychiatry, D-80804 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Lucae, Susanne" sort="Lucae, Susanne" uniqKey="Lucae S" first="Susanne" last="Lucae">Susanne Lucae</name><affiliation><nlm:aff id="aff12">Max-Planck-Institute of Psychiatry, D-80804 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Jamain, Stephane" sort="Jamain, Stephane" uniqKey="Jamain S" first="Stéphane" last="Jamain">Stéphane Jamain</name><affiliation><nlm:aff id="aff13">INSERM U 955, IMRB, Psychiatry Genetics, Fondation Fondamental, ENBREC, F-94010 Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Faculty of Medicine, University of Paris Est, F-75005 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">AP-HP, Henri Mondor-Albert Chenevier Group, Department of Psychiatry, F-94000 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><affiliation><nlm:aff id="aff13">INSERM U 955, IMRB, Psychiatry Genetics, Fondation Fondamental, ENBREC, F-94010 Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Faculty of Medicine, University of Paris Est, F-75005 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">AP-HP, Henri Mondor-Albert Chenevier Group, Department of Psychiatry, F-94000 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><affiliation><nlm:aff id="aff13">INSERM U 955, IMRB, Psychiatry Genetics, Fondation Fondamental, ENBREC, F-94010 Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Faculty of Medicine, University of Paris Est, F-75005 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">AP-HP, Henri Mondor-Albert Chenevier Group, Department of Psychiatry, F-94000 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Etain">Bruno Etain</name><affiliation><nlm:aff id="aff13">INSERM U 955, IMRB, Psychiatry Genetics, Fondation Fondamental, ENBREC, F-94010 Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Faculty of Medicine, University of Paris Est, F-75005 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">AP-HP, Henri Mondor-Albert Chenevier Group, Department of Psychiatry, F-94000 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Henry, Chantal" sort="Henry, Chantal" uniqKey="Henry C" first="Chantal" last="Henry">Chantal Henry</name><affiliation><nlm:aff id="aff13">INSERM U 955, IMRB, Psychiatry Genetics, Fondation Fondamental, ENBREC, F-94010 Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Faculty of Medicine, University of Paris Est, F-75005 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">AP-HP, Henri Mondor-Albert Chenevier Group, Department of Psychiatry, F-94000 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Kahn, Jean Pierre" sort="Kahn, Jean Pierre" uniqKey="Kahn J" first="Jean-Pierre" last="Kahn">Jean-Pierre Kahn</name><affiliation><nlm:aff id="aff16">Department of Psychiatry and Clinical Psychology, CHU de Nancy, Jeanne-d'Arc Hospital, F-54200 Toul, France, and Fondation Fondamental, F-94010 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Heath, Simon" sort="Heath, Simon" uniqKey="Heath S" first="Simon" last="Heath">Simon Heath</name><affiliation><nlm:aff id="aff17">Centre National de Génotypage, F-91057 Evry, France</nlm:aff></affiliation></author><author><name sortKey="Hamshere, Marian" sort="Hamshere, Marian" uniqKey="Hamshere M" first="Marian" last="Hamshere">Marian Hamshere</name><affiliation><nlm:aff id="aff19">Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="O Donovan, Michael C" sort="O Donovan, Michael C" uniqKey="O Donovan M" first="Michael C." last="O'Donovan">Michael C. O'Donovan</name><affiliation><nlm:aff id="aff19">Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J." last="Owen">Michael J. Owen</name><affiliation><nlm:aff id="aff19">Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Craddock, Nick" sort="Craddock, Nick" uniqKey="Craddock N" first="Nick" last="Craddock">Nick Craddock</name><affiliation><nlm:aff id="aff19">Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Schwarz, Markus" sort="Schwarz, Markus" uniqKey="Schwarz M" first="Markus" last="Schwarz">Markus Schwarz</name><affiliation><nlm:aff id="aff20">Psychiatric Center Nordbaden, D-69168 Wiesloch, Germany</nlm:aff></affiliation></author><author><name sortKey="Vedder, Helmut" sort="Vedder, Helmut" uniqKey="Vedder H" first="Helmut" last="Vedder">Helmut Vedder</name><affiliation><nlm:aff id="aff20">Psychiatric Center Nordbaden, D-69168 Wiesloch, Germany</nlm:aff></affiliation></author><author><name sortKey="Kammerer Ciernioch, Jutta" sort="Kammerer Ciernioch, Jutta" uniqKey="Kammerer Ciernioch J" first="Jutta" last="Kammerer-Ciernioch">Jutta Kammerer-Ciernioch</name><affiliation><nlm:aff id="aff20">Psychiatric Center Nordbaden, D-69168 Wiesloch, Germany</nlm:aff></affiliation></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation><nlm:aff id="aff21">Department of Psychiatry, University of Würzburg, D-97070 Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sasse, Johanna" sort="Sasse, Johanna" uniqKey="Sasse J" first="Johanna" last="Sasse">Johanna Sasse</name><affiliation><nlm:aff id="aff22">Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, D-01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><affiliation><nlm:aff id="aff22">Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, D-01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Hautzinger, Martin" sort="Hautzinger, Martin" uniqKey="Hautzinger M" first="Martin" last="Hautzinger">Martin Hautzinger</name><affiliation><nlm:aff id="aff23">Department of Clinical and Developmental Psychology, Institute of Psychology, University of Tübingen, D-72074 Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name><affiliation><nlm:aff id="aff24">School of Psychiatry, University of New South Wales, NSW 2052, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff25">Black Dog Institute, Prince of Wales Hospital, Randwick, NSW 2031, Australia</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B." last="Mitchell">Philip B. Mitchell</name><affiliation><nlm:aff id="aff24">School of Psychiatry, University of New South Wales, NSW 2052, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff25">Black Dog Institute, Prince of Wales Hospital, Randwick, NSW 2031, Australia</nlm:aff></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name><affiliation><nlm:aff id="aff26">Neuroscience Research Australia, Barker Street, Randwick, Sydney NSW 2031, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff27">School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney NSW 2052, Australia</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="aff28">Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><affiliation><nlm:aff id="aff28">Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Gordon, Scott D" sort="Gordon, Scott D" uniqKey="Gordon S" first="Scott D." last="Gordon">Scott D. Gordon</name><affiliation><nlm:aff id="aff28">Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="aff28">Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Gustafsson, Omar" sort="Gustafsson, Omar" uniqKey="Gustafsson O" first="Omar" last="Gustafsson">Omar Gustafsson</name><affiliation><nlm:aff id="aff29">Department of Psychiatry, Oslo University Hospital, N-0407 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Andreassen, Ole" sort="Andreassen, Ole" uniqKey="Andreassen O" first="Ole" last="Andreassen">Ole Andreassen</name><affiliation><nlm:aff id="aff29">Department of Psychiatry, Oslo University Hospital, N-0407 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="aff30">Institute of Psychiatry, University of Oslo, N-0450 Oslo</nlm:aff></affiliation></author><author><name sortKey="Djurovic, Srdjan" sort="Djurovic, Srdjan" uniqKey="Djurovic S" first="Srdjan" last="Djurovic">Srdjan Djurovic</name><affiliation><nlm:aff id="aff29">Department of Psychiatry, Oslo University Hospital, N-0407 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="aff30">Institute of Psychiatry, University of Oslo, N-0450 Oslo</nlm:aff></affiliation><affiliation><nlm:aff id="aff31">Department of Medical Genetics, Oslo University Hospital, N-0407 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Sigurdsson, Engilbert" sort="Sigurdsson, Engilbert" uniqKey="Sigurdsson E" first="Engilbert" last="Sigurdsson">Engilbert Sigurdsson</name><affiliation><nlm:aff id="aff32">Department of Psychiatry, University of Iceland, National University Hospital, Hringbraut, IS-101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Steinberg, Stacy" sort="Steinberg, Stacy" uniqKey="Steinberg S" first="Stacy" last="Steinberg">Stacy Steinberg</name><affiliation><nlm:aff id="aff33">CNS Division, deCODE Genetics, Sturlugata 8, IS-101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Hreinn" sort="Stefansson, Hreinn" uniqKey="Stefansson H" first="Hreinn" last="Stefansson">Hreinn Stefansson</name><affiliation><nlm:aff id="aff33">CNS Division, deCODE Genetics, Sturlugata 8, IS-101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="aff33">CNS Division, deCODE Genetics, Sturlugata 8, IS-101 Reykjavík, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="aff34">School of Medicine, University of Iceland, IS-101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Kapur Pojskic, Lejla" sort="Kapur Pojskic, Lejla" uniqKey="Kapur Pojskic L" first="Lejla" last="Kapur-Pojskic">Lejla Kapur-Pojskic</name><affiliation><nlm:aff id="aff35">Laboratory for Human Genetics, INGEB, University of Sarajevo, BA-71000 Sarajevo, Bosnia and Herzegovina</nlm:aff></affiliation></author><author><name sortKey="Oruc, Liliana" sort="Oruc, Liliana" uniqKey="Oruc L" first="Liliana" last="Oruc">Liliana Oruc</name><affiliation><nlm:aff id="aff36">Psychiatric Clinic, Clinical Center, University of Sarajevo, BA-71000 Sarajevo, Bosnia and Herzegovina</nlm:aff></affiliation></author><author><name sortKey="Rivas, Fabio" sort="Rivas, Fabio" uniqKey="Rivas F" first="Fabio" last="Rivas">Fabio Rivas</name><affiliation><nlm:aff id="aff37">Civil Hospital Carlos Haya, ES-29010 Málaga, Spain</nlm:aff></affiliation></author><author><name sortKey="Mayoral, Fermin" sort="Mayoral, Fermin" uniqKey="Mayoral F" first="Fermín" last="Mayoral">Fermín Mayoral</name><affiliation><nlm:aff id="aff37">Civil Hospital Carlos Haya, ES-29010 Málaga, Spain</nlm:aff></affiliation></author><author><name sortKey="Chuchalin, Alexander" sort="Chuchalin, Alexander" uniqKey="Chuchalin A" first="Alexander" last="Chuchalin">Alexander Chuchalin</name><affiliation><nlm:aff id="aff38">Institute of Pulmonology, Russian State Medical University, 105077 Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Babadjanova, Gulja" sort="Babadjanova, Gulja" uniqKey="Babadjanova G" first="Gulja" last="Babadjanova">Gulja Babadjanova</name><affiliation><nlm:aff id="aff38">Institute of Pulmonology, Russian State Medical University, 105077 Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Tiganov, Alexander S" sort="Tiganov, Alexander S" uniqKey="Tiganov A" first="Alexander S." last="Tiganov">Alexander S. Tiganov</name><affiliation><nlm:aff id="aff39">Russian Academy of Medical Sciences, Mental Health Research Center, 115522 Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Pantelejeva, Galina" sort="Pantelejeva, Galina" uniqKey="Pantelejeva G" first="Galina" last="Pantelejeva">Galina Pantelejeva</name><affiliation><nlm:aff id="aff39">Russian Academy of Medical Sciences, Mental Health Research Center, 115522 Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Abramova, Lilia I" sort="Abramova, Lilia I" uniqKey="Abramova L" first="Lilia I." last="Abramova">Lilia I. Abramova</name><affiliation><nlm:aff id="aff39">Russian Academy of Medical Sciences, Mental Health Research Center, 115522 Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name><affiliation><nlm:aff id="aff40">Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, RO-041914 Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Diaconu, Carmen C" sort="Diaconu, Carmen C" uniqKey="Diaconu C" first="Carmen C." last="Diaconu">Carmen C. Diaconu</name><affiliation><nlm:aff id="aff41">Stefan S. Nicolau Institute of Virology, Romanian Academy, RO-030304 Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Czerski, Piotr M" sort="Czerski, Piotr M" uniqKey="Czerski P" first="Piotr M." last="Czerski">Piotr M. Czerski</name><affiliation><nlm:aff id="aff42">Department of Psychiatry, Poznan University of Medical Sciences, PL-60-572 Poznan, Poland</nlm:aff></affiliation></author><author><name sortKey="Hauser, Joanna" sort="Hauser, Joanna" uniqKey="Hauser J" first="Joanna" last="Hauser">Joanna Hauser</name><affiliation><nlm:aff id="aff42">Department of Psychiatry, Poznan University of Medical Sciences, PL-60-572 Poznan, Poland</nlm:aff></affiliation></author><author><name sortKey="Zimmer, Andreas" sort="Zimmer, Andreas" uniqKey="Zimmer A" first="Andreas" last="Zimmer">Andreas Zimmer</name><affiliation><nlm:aff id="aff5">Institute of Molecular Psychiatry, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="aff17">Centre National de Génotypage, F-91057 Evry, France</nlm:aff></affiliation></author><author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G." last="Schulze">Thomas G. Schulze</name><affiliation><nlm:aff id="aff43">Department of Psychiatry and Psychotherapy, University Medical Center, University of Göttingen, D-37075 Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Wienker, Thomas F" sort="Wienker, Thomas F" uniqKey="Wienker T" first="Thomas F." last="Wienker">Thomas F. Wienker</name><affiliation><nlm:aff id="aff4">Institute of Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Johannes" sort="Schumacher, Johannes" uniqKey="Schumacher J" first="Johannes" last="Schumacher">Johannes Schumacher</name><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name><affiliation><nlm:aff id="aff44">Department of Psychiatry, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Propping, Peter" sort="Propping, Peter" uniqKey="Propping P" first="Peter" last="Propping">Peter Propping</name><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><affiliation><nlm:aff id="aff6">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Mannheim, D-68159 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21353194</idno><idno type="pmc">3059436</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059436</idno><idno type="RBID">PMC:3059436</idno><idno type="doi">10.1016/j.ajhg.2011.01.017</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001193</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001193</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder</title><author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation><nlm:aff id="aff1">Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, D-52425 Juelich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Degenhardt, Franziska A" sort="Degenhardt, Franziska A" uniqKey="Degenhardt F" first="Franziska A." last="Degenhardt">Franziska A. Degenhardt</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Institute of Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Mir, Xavier" sort="Mir, Xavier" uniqKey="Mir X" first="Xavier" last="Mir">Xavier Mir</name><affiliation><nlm:aff id="aff5">Institute of Molecular Psychiatry, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Strohmaier, Jana" sort="Strohmaier, Jana" uniqKey="Strohmaier J" first="Jana" last="Strohmaier">Jana Strohmaier</name><affiliation><nlm:aff id="aff6">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Mannheim, D-68159 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Steffens, Michael" sort="Steffens, Michael" uniqKey="Steffens M" first="Michael" last="Steffens">Michael Steffens</name><affiliation><nlm:aff id="aff4">Institute of Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Meesters, Christian" sort="Meesters, Christian" uniqKey="Meesters C" first="Christian" last="Meesters">Christian Meesters</name><affiliation><nlm:aff id="aff4">Institute of Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Weingarten, Moritz" sort="Weingarten, Moritz" uniqKey="Weingarten M" first="Moritz" last="Weingarten">Moritz Weingarten</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Priebe, Lutz" sort="Priebe, Lutz" uniqKey="Priebe L" first="Lutz" last="Priebe">Lutz Priebe</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Haenisch, Britta" sort="Haenisch, Britta" uniqKey="Haenisch B" first="Britta" last="Haenisch">Britta Haenisch</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Alexander, Michael" sort="Alexander, Michael" uniqKey="Alexander M" first="Michael" last="Alexander">Michael Alexander</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Vollmer, Jennifer" sort="Vollmer, Jennifer" uniqKey="Vollmer J" first="Jennifer" last="Vollmer">Jennifer Vollmer</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Breuer, Rene" sort="Breuer, Rene" uniqKey="Breuer R" first="René" last="Breuer">René Breuer</name><affiliation><nlm:aff id="aff6">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Mannheim, D-68159 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Schm L, Christine" sort="Schm L, Christine" uniqKey="Schm L C" first="Christine" last="Schm L">Christine Schm L</name><affiliation><nlm:aff id="aff6">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Mannheim, D-68159 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Tessmann, Peter" sort="Tessmann, Peter" uniqKey="Tessmann P" first="Peter" last="Tessmann">Peter Tessmann</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation><nlm:aff id="aff7">Institute of Medical Informatics, Biometry, and Epidemiology, University Duisburg-Essen, D-45147 Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation><nlm:aff id="aff8">Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff9">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Klinikum Grosshadern, D-81377 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation><nlm:aff id="aff11">Institute of Clinical Molecular Biology, University of Kiel, D-24105 Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation><nlm:aff id="aff12">Max-Planck-Institute of Psychiatry, D-80804 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Lucae, Susanne" sort="Lucae, Susanne" uniqKey="Lucae S" first="Susanne" last="Lucae">Susanne Lucae</name><affiliation><nlm:aff id="aff12">Max-Planck-Institute of Psychiatry, D-80804 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Jamain, Stephane" sort="Jamain, Stephane" uniqKey="Jamain S" first="Stéphane" last="Jamain">Stéphane Jamain</name><affiliation><nlm:aff id="aff13">INSERM U 955, IMRB, Psychiatry Genetics, Fondation Fondamental, ENBREC, F-94010 Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Faculty of Medicine, University of Paris Est, F-75005 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">AP-HP, Henri Mondor-Albert Chenevier Group, Department of Psychiatry, F-94000 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><affiliation><nlm:aff id="aff13">INSERM U 955, IMRB, Psychiatry Genetics, Fondation Fondamental, ENBREC, F-94010 Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Faculty of Medicine, University of Paris Est, F-75005 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">AP-HP, Henri Mondor-Albert Chenevier Group, Department of Psychiatry, F-94000 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><affiliation><nlm:aff id="aff13">INSERM U 955, IMRB, Psychiatry Genetics, Fondation Fondamental, ENBREC, F-94010 Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Faculty of Medicine, University of Paris Est, F-75005 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">AP-HP, Henri Mondor-Albert Chenevier Group, Department of Psychiatry, F-94000 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Etain">Bruno Etain</name><affiliation><nlm:aff id="aff13">INSERM U 955, IMRB, Psychiatry Genetics, Fondation Fondamental, ENBREC, F-94010 Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Faculty of Medicine, University of Paris Est, F-75005 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">AP-HP, Henri Mondor-Albert Chenevier Group, Department of Psychiatry, F-94000 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Henry, Chantal" sort="Henry, Chantal" uniqKey="Henry C" first="Chantal" last="Henry">Chantal Henry</name><affiliation><nlm:aff id="aff13">INSERM U 955, IMRB, Psychiatry Genetics, Fondation Fondamental, ENBREC, F-94010 Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Faculty of Medicine, University of Paris Est, F-75005 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">AP-HP, Henri Mondor-Albert Chenevier Group, Department of Psychiatry, F-94000 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Kahn, Jean Pierre" sort="Kahn, Jean Pierre" uniqKey="Kahn J" first="Jean-Pierre" last="Kahn">Jean-Pierre Kahn</name><affiliation><nlm:aff id="aff16">Department of Psychiatry and Clinical Psychology, CHU de Nancy, Jeanne-d'Arc Hospital, F-54200 Toul, France, and Fondation Fondamental, F-94010 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Heath, Simon" sort="Heath, Simon" uniqKey="Heath S" first="Simon" last="Heath">Simon Heath</name><affiliation><nlm:aff id="aff17">Centre National de Génotypage, F-91057 Evry, France</nlm:aff></affiliation></author><author><name sortKey="Hamshere, Marian" sort="Hamshere, Marian" uniqKey="Hamshere M" first="Marian" last="Hamshere">Marian Hamshere</name><affiliation><nlm:aff id="aff19">Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="O Donovan, Michael C" sort="O Donovan, Michael C" uniqKey="O Donovan M" first="Michael C." last="O'Donovan">Michael C. O'Donovan</name><affiliation><nlm:aff id="aff19">Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J." last="Owen">Michael J. Owen</name><affiliation><nlm:aff id="aff19">Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Craddock, Nick" sort="Craddock, Nick" uniqKey="Craddock N" first="Nick" last="Craddock">Nick Craddock</name><affiliation><nlm:aff id="aff19">Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Schwarz, Markus" sort="Schwarz, Markus" uniqKey="Schwarz M" first="Markus" last="Schwarz">Markus Schwarz</name><affiliation><nlm:aff id="aff20">Psychiatric Center Nordbaden, D-69168 Wiesloch, Germany</nlm:aff></affiliation></author><author><name sortKey="Vedder, Helmut" sort="Vedder, Helmut" uniqKey="Vedder H" first="Helmut" last="Vedder">Helmut Vedder</name><affiliation><nlm:aff id="aff20">Psychiatric Center Nordbaden, D-69168 Wiesloch, Germany</nlm:aff></affiliation></author><author><name sortKey="Kammerer Ciernioch, Jutta" sort="Kammerer Ciernioch, Jutta" uniqKey="Kammerer Ciernioch J" first="Jutta" last="Kammerer-Ciernioch">Jutta Kammerer-Ciernioch</name><affiliation><nlm:aff id="aff20">Psychiatric Center Nordbaden, D-69168 Wiesloch, Germany</nlm:aff></affiliation></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation><nlm:aff id="aff21">Department of Psychiatry, University of Würzburg, D-97070 Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sasse, Johanna" sort="Sasse, Johanna" uniqKey="Sasse J" first="Johanna" last="Sasse">Johanna Sasse</name><affiliation><nlm:aff id="aff22">Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, D-01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><affiliation><nlm:aff id="aff22">Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, D-01307 Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Hautzinger, Martin" sort="Hautzinger, Martin" uniqKey="Hautzinger M" first="Martin" last="Hautzinger">Martin Hautzinger</name><affiliation><nlm:aff id="aff23">Department of Clinical and Developmental Psychology, Institute of Psychology, University of Tübingen, D-72074 Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name><affiliation><nlm:aff id="aff24">School of Psychiatry, University of New South Wales, NSW 2052, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff25">Black Dog Institute, Prince of Wales Hospital, Randwick, NSW 2031, Australia</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B." last="Mitchell">Philip B. Mitchell</name><affiliation><nlm:aff id="aff24">School of Psychiatry, University of New South Wales, NSW 2052, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff25">Black Dog Institute, Prince of Wales Hospital, Randwick, NSW 2031, Australia</nlm:aff></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name><affiliation><nlm:aff id="aff26">Neuroscience Research Australia, Barker Street, Randwick, Sydney NSW 2031, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff27">School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney NSW 2052, Australia</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="aff28">Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><affiliation><nlm:aff id="aff28">Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Gordon, Scott D" sort="Gordon, Scott D" uniqKey="Gordon S" first="Scott D." last="Gordon">Scott D. Gordon</name><affiliation><nlm:aff id="aff28">Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="aff28">Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Gustafsson, Omar" sort="Gustafsson, Omar" uniqKey="Gustafsson O" first="Omar" last="Gustafsson">Omar Gustafsson</name><affiliation><nlm:aff id="aff29">Department of Psychiatry, Oslo University Hospital, N-0407 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Andreassen, Ole" sort="Andreassen, Ole" uniqKey="Andreassen O" first="Ole" last="Andreassen">Ole Andreassen</name><affiliation><nlm:aff id="aff29">Department of Psychiatry, Oslo University Hospital, N-0407 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="aff30">Institute of Psychiatry, University of Oslo, N-0450 Oslo</nlm:aff></affiliation></author><author><name sortKey="Djurovic, Srdjan" sort="Djurovic, Srdjan" uniqKey="Djurovic S" first="Srdjan" last="Djurovic">Srdjan Djurovic</name><affiliation><nlm:aff id="aff29">Department of Psychiatry, Oslo University Hospital, N-0407 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="aff30">Institute of Psychiatry, University of Oslo, N-0450 Oslo</nlm:aff></affiliation><affiliation><nlm:aff id="aff31">Department of Medical Genetics, Oslo University Hospital, N-0407 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Sigurdsson, Engilbert" sort="Sigurdsson, Engilbert" uniqKey="Sigurdsson E" first="Engilbert" last="Sigurdsson">Engilbert Sigurdsson</name><affiliation><nlm:aff id="aff32">Department of Psychiatry, University of Iceland, National University Hospital, Hringbraut, IS-101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Steinberg, Stacy" sort="Steinberg, Stacy" uniqKey="Steinberg S" first="Stacy" last="Steinberg">Stacy Steinberg</name><affiliation><nlm:aff id="aff33">CNS Division, deCODE Genetics, Sturlugata 8, IS-101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Hreinn" sort="Stefansson, Hreinn" uniqKey="Stefansson H" first="Hreinn" last="Stefansson">Hreinn Stefansson</name><affiliation><nlm:aff id="aff33">CNS Division, deCODE Genetics, Sturlugata 8, IS-101 Reykjavík, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="aff33">CNS Division, deCODE Genetics, Sturlugata 8, IS-101 Reykjavík, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="aff34">School of Medicine, University of Iceland, IS-101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Kapur Pojskic, Lejla" sort="Kapur Pojskic, Lejla" uniqKey="Kapur Pojskic L" first="Lejla" last="Kapur-Pojskic">Lejla Kapur-Pojskic</name><affiliation><nlm:aff id="aff35">Laboratory for Human Genetics, INGEB, University of Sarajevo, BA-71000 Sarajevo, Bosnia and Herzegovina</nlm:aff></affiliation></author><author><name sortKey="Oruc, Liliana" sort="Oruc, Liliana" uniqKey="Oruc L" first="Liliana" last="Oruc">Liliana Oruc</name><affiliation><nlm:aff id="aff36">Psychiatric Clinic, Clinical Center, University of Sarajevo, BA-71000 Sarajevo, Bosnia and Herzegovina</nlm:aff></affiliation></author><author><name sortKey="Rivas, Fabio" sort="Rivas, Fabio" uniqKey="Rivas F" first="Fabio" last="Rivas">Fabio Rivas</name><affiliation><nlm:aff id="aff37">Civil Hospital Carlos Haya, ES-29010 Málaga, Spain</nlm:aff></affiliation></author><author><name sortKey="Mayoral, Fermin" sort="Mayoral, Fermin" uniqKey="Mayoral F" first="Fermín" last="Mayoral">Fermín Mayoral</name><affiliation><nlm:aff id="aff37">Civil Hospital Carlos Haya, ES-29010 Málaga, Spain</nlm:aff></affiliation></author><author><name sortKey="Chuchalin, Alexander" sort="Chuchalin, Alexander" uniqKey="Chuchalin A" first="Alexander" last="Chuchalin">Alexander Chuchalin</name><affiliation><nlm:aff id="aff38">Institute of Pulmonology, Russian State Medical University, 105077 Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Babadjanova, Gulja" sort="Babadjanova, Gulja" uniqKey="Babadjanova G" first="Gulja" last="Babadjanova">Gulja Babadjanova</name><affiliation><nlm:aff id="aff38">Institute of Pulmonology, Russian State Medical University, 105077 Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Tiganov, Alexander S" sort="Tiganov, Alexander S" uniqKey="Tiganov A" first="Alexander S." last="Tiganov">Alexander S. Tiganov</name><affiliation><nlm:aff id="aff39">Russian Academy of Medical Sciences, Mental Health Research Center, 115522 Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Pantelejeva, Galina" sort="Pantelejeva, Galina" uniqKey="Pantelejeva G" first="Galina" last="Pantelejeva">Galina Pantelejeva</name><affiliation><nlm:aff id="aff39">Russian Academy of Medical Sciences, Mental Health Research Center, 115522 Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Abramova, Lilia I" sort="Abramova, Lilia I" uniqKey="Abramova L" first="Lilia I." last="Abramova">Lilia I. Abramova</name><affiliation><nlm:aff id="aff39">Russian Academy of Medical Sciences, Mental Health Research Center, 115522 Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name><affiliation><nlm:aff id="aff40">Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, RO-041914 Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Diaconu, Carmen C" sort="Diaconu, Carmen C" uniqKey="Diaconu C" first="Carmen C." last="Diaconu">Carmen C. Diaconu</name><affiliation><nlm:aff id="aff41">Stefan S. Nicolau Institute of Virology, Romanian Academy, RO-030304 Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Czerski, Piotr M" sort="Czerski, Piotr M" uniqKey="Czerski P" first="Piotr M." last="Czerski">Piotr M. Czerski</name><affiliation><nlm:aff id="aff42">Department of Psychiatry, Poznan University of Medical Sciences, PL-60-572 Poznan, Poland</nlm:aff></affiliation></author><author><name sortKey="Hauser, Joanna" sort="Hauser, Joanna" uniqKey="Hauser J" first="Joanna" last="Hauser">Joanna Hauser</name><affiliation><nlm:aff id="aff42">Department of Psychiatry, Poznan University of Medical Sciences, PL-60-572 Poznan, Poland</nlm:aff></affiliation></author><author><name sortKey="Zimmer, Andreas" sort="Zimmer, Andreas" uniqKey="Zimmer A" first="Andreas" last="Zimmer">Andreas Zimmer</name><affiliation><nlm:aff id="aff5">Institute of Molecular Psychiatry, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="aff17">Centre National de Génotypage, F-91057 Evry, France</nlm:aff></affiliation></author><author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G." last="Schulze">Thomas G. Schulze</name><affiliation><nlm:aff id="aff43">Department of Psychiatry and Psychotherapy, University Medical Center, University of Göttingen, D-37075 Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Wienker, Thomas F" sort="Wienker, Thomas F" uniqKey="Wienker T" first="Thomas F." last="Wienker">Thomas F. Wienker</name><affiliation><nlm:aff id="aff4">Institute of Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Johannes" sort="Schumacher, Johannes" uniqKey="Schumacher J" first="Johannes" last="Schumacher">Johannes Schumacher</name><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name><affiliation><nlm:aff id="aff44">Department of Psychiatry, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Propping, Peter" sort="Propping, Peter" uniqKey="Propping P" first="Peter" last="Propping">Peter Propping</name><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><affiliation><nlm:aff id="aff6">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Mannheim, D-68159 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:aff id="aff2">Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</nlm:aff></affiliation></author></analytic><series><title level="j">American Journal of Human Genetics</title><idno type="ISSN">0002-9297</idno><idno type="eISSN">1537-6605</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar disorder (BD), a common neuropsychiatric disorder. In the GWAS, we investigated 499,494 autosomal and 12,484 X-chromosomal SNPs in 682 patients with BD and in 1300 controls. In the first follow-up step, we tested the most significant 48 SNPs in 1729 patients with BD and in 2313 controls. Eight SNPs showed nominally significant association with BD and were introduced to a meta-analysis of the GWAS and the first follow-up samples. Genetic variation in the neurocan gene (<italic>NCAN</italic>) showed genome-wide significant association with BD in 2411 patients and 3613 controls (rs1064395, p = 3.02 × 10<sup>−8</sup>; odds ratio = 1.31). In a second follow-up step, we replicated this finding in independent samples of BD, totaling 6030 patients and 31,749 controls (p = 2.74 × 10<sup>−4</sup>; odds ratio = 1.12). The combined analysis of all study samples yielded a p value of 2.14 × 10<sup>−9</sup> (odds ratio = 1.17). Our results provide evidence that rs1064395 is a common risk factor for BD. <italic>NCAN</italic> encodes neurocan, an extracellular matrix glycoprotein, which is thought to be involved in cell adhesion and migration. We found that expression in mice is localized within cortical and hippocampal areas. These areas are involved in cognition and emotion regulation and have previously been implicated in BD by neuropsychological, neuroimaging, and postmortem studies.</p></div></front></TEI><pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Hum Genet</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Hum. Genet</journal-id><journal-title-group><journal-title>American Journal of Human Genetics</journal-title></journal-title-group><issn pub-type="ppub">0002-9297</issn><issn pub-type="epub">1537-6605</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21353194</article-id><article-id pub-id-type="pmc">3059436</article-id><article-id pub-id-type="publisher-id">S0002-9297(11)00018-8</article-id><article-id pub-id-type="doi">10.1016/j.ajhg.2011.01.017</article-id><article-categories><subj-group subj-group-type="heading"><subject>Report</subject></subj-group></article-categories><title-group><article-title>Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cichon</surname><given-names>Sven</given-names></name><email>sven.cichon@uni-bonn.de</email><xref 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ref-type="aff">29</xref></contrib><contrib contrib-type="author"><name><surname>Andreassen</surname><given-names>Ole</given-names></name><xref rid="aff29" ref-type="aff">29</xref><xref rid="aff30" ref-type="aff">30</xref></contrib><contrib contrib-type="author"><name><surname>Djurovic</surname><given-names>Srdjan</given-names></name><xref rid="aff29" ref-type="aff">29</xref><xref rid="aff30" ref-type="aff">30</xref><xref rid="aff31" ref-type="aff">31</xref></contrib><contrib contrib-type="author"><name><surname>Sigurdsson</surname><given-names>Engilbert</given-names></name><xref rid="aff32" ref-type="aff">32</xref></contrib><contrib contrib-type="author"><name><surname>Steinberg</surname><given-names>Stacy</given-names></name><xref rid="aff33" ref-type="aff">33</xref></contrib><contrib contrib-type="author"><name><surname>Stefansson</surname><given-names>Hreinn</given-names></name><xref rid="aff33" ref-type="aff">33</xref></contrib><contrib contrib-type="author"><name><surname>Stefansson</surname><given-names>Kari</given-names></name><xref rid="aff33" ref-type="aff">33</xref><xref rid="aff34" ref-type="aff">34</xref></contrib><contrib contrib-type="author"><name><surname>Kapur-Pojskic</surname><given-names>Lejla</given-names></name><xref rid="aff35" ref-type="aff">35</xref></contrib><contrib contrib-type="author"><name><surname>Oruc</surname><given-names>Liliana</given-names></name><xref rid="aff36" ref-type="aff">36</xref></contrib><contrib contrib-type="author"><name><surname>Rivas</surname><given-names>Fabio</given-names></name><xref rid="aff37" ref-type="aff">37</xref></contrib><contrib contrib-type="author"><name><surname>Mayoral</surname><given-names>Fermín</given-names></name><xref rid="aff37" ref-type="aff">37</xref></contrib><contrib contrib-type="author"><name><surname>Chuchalin</surname><given-names>Alexander</given-names></name><xref rid="aff38" ref-type="aff">38</xref></contrib><contrib contrib-type="author"><name><surname>Babadjanova</surname><given-names>Gulja</given-names></name><xref rid="aff38" ref-type="aff">38</xref></contrib><contrib contrib-type="author"><name><surname>Tiganov</surname><given-names>Alexander S.</given-names></name><xref rid="aff39" ref-type="aff">39</xref></contrib><contrib contrib-type="author"><name><surname>Pantelejeva</surname><given-names>Galina</given-names></name><xref rid="aff39" ref-type="aff">39</xref></contrib><contrib contrib-type="author"><name><surname>Abramova</surname><given-names>Lilia I.</given-names></name><xref rid="aff39" ref-type="aff">39</xref></contrib><contrib contrib-type="author"><name><surname>Grigoroiu-Serbanescu</surname><given-names>Maria</given-names></name><xref rid="aff40" ref-type="aff">40</xref></contrib><contrib contrib-type="author"><name><surname>Diaconu</surname><given-names>Carmen C.</given-names></name><xref rid="aff41" ref-type="aff">41</xref></contrib><contrib contrib-type="author"><name><surname>Czerski</surname><given-names>Piotr M.</given-names></name><xref rid="aff42" ref-type="aff">42</xref></contrib><contrib contrib-type="author"><name><surname>Hauser</surname><given-names>Joanna</given-names></name><xref rid="aff42" ref-type="aff">42</xref></contrib><contrib contrib-type="author"><name><surname>Zimmer</surname><given-names>Andreas</given-names></name><xref rid="aff5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Lathrop</surname><given-names>Mark</given-names></name><xref rid="aff17" ref-type="aff">17</xref></contrib><contrib contrib-type="author"><name><surname>Schulze</surname><given-names>Thomas G.</given-names></name><xref rid="aff43" ref-type="aff">43</xref></contrib><contrib contrib-type="author"><name><surname>Wienker</surname><given-names>Thomas F.</given-names></name><xref rid="aff4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Schumacher</surname><given-names>Johannes</given-names></name><xref rid="aff3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Maier</surname><given-names>Wolfgang</given-names></name><xref rid="aff44" ref-type="aff">44</xref></contrib><contrib contrib-type="author"><name><surname>Propping</surname><given-names>Peter</given-names></name><xref rid="aff3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Rietschel</surname><given-names>Marcella</given-names></name><xref rid="aff6" ref-type="aff">6</xref><xref rid="fn1" ref-type="fn">45</xref></contrib><contrib contrib-type="author"><name><surname>Nöthen</surname><given-names>Markus M.</given-names></name><xref rid="aff2" ref-type="aff">2</xref><xref rid="aff3" ref-type="aff">3</xref><xref rid="fn1" ref-type="fn">45</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, D-52425 Juelich, Germany</aff><aff id="aff2"><label>2</label>Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany</aff><aff id="aff3"><label>3</label>Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany</aff><aff id="aff4"><label>4</label>Institute of Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany</aff><aff id="aff5"><label>5</label>Institute of Molecular Psychiatry, University of Bonn, D-53127 Bonn, Germany</aff><aff id="aff6"><label>6</label>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Mannheim, D-68159 Mannheim, Germany</aff><aff id="aff7"><label>7</label>Institute of Medical Informatics, Biometry, and Epidemiology, University Duisburg-Essen, D-45147 Essen, Germany</aff><aff id="aff8"><label>8</label>Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</aff><aff id="aff9"><label>9</label>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany</aff><aff id="aff10"><label>10</label>Klinikum Grosshadern, D-81377 Munich, Germany</aff><aff id="aff11"><label>11</label>Institute of Clinical Molecular Biology, University of Kiel, D-24105 Kiel, Germany</aff><aff id="aff12"><label>12</label>Max-Planck-Institute of Psychiatry, D-80804 Munich, Germany</aff><aff id="aff13"><label>13</label>INSERM U 955, IMRB, Psychiatry Genetics, Fondation Fondamental, ENBREC, F-94010 Créteil, France</aff><aff id="aff14"><label>14</label>Faculty of Medicine, University of Paris Est, F-75005 Paris, France</aff><aff id="aff15"><label>15</label>AP-HP, Henri Mondor-Albert Chenevier Group, Department of Psychiatry, F-94000 Créteil, France</aff><aff id="aff16"><label>16</label>Department of Psychiatry and Clinical Psychology, CHU de Nancy, Jeanne-d'Arc Hospital, F-54200 Toul, France, and Fondation Fondamental, F-94010 Créteil, France</aff><aff id="aff17"><label>17</label>Centre National de Génotypage, F-91057 Evry, France</aff><aff id="aff18"><label>18</label>A full list of authors is provided in the Supplemental Data</aff><aff id="aff19"><label>19</label>Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom</aff><aff id="aff20"><label>20</label>Psychiatric Center Nordbaden, D-69168 Wiesloch, Germany</aff><aff id="aff21"><label>21</label>Department of Psychiatry, University of Würzburg, D-97070 Würzburg, Germany</aff><aff id="aff22"><label>22</label>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, D-01307 Dresden, Germany</aff><aff id="aff23"><label>23</label>Department of Clinical and Developmental Psychology, Institute of Psychology, University of Tübingen, D-72074 Tübingen, Germany</aff><aff id="aff24"><label>24</label>School of Psychiatry, University of New South Wales, NSW 2052, Australia</aff><aff id="aff25"><label>25</label>Black Dog Institute, Prince of Wales Hospital, Randwick, NSW 2031, Australia</aff><aff id="aff26"><label>26</label>Neuroscience Research Australia, Barker Street, Randwick, Sydney NSW 2031, Australia</aff><aff id="aff27"><label>27</label>School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney NSW 2052, Australia</aff><aff id="aff28"><label>28</label>Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia</aff><aff id="aff29"><label>29</label>Department of Psychiatry, Oslo University Hospital, N-0407 Oslo, Norway</aff><aff id="aff30"><label>30</label>Institute of Psychiatry, University of Oslo, N-0450 Oslo</aff><aff id="aff31"><label>31</label>Department of Medical Genetics, Oslo University Hospital, N-0407 Oslo, Norway</aff><aff id="aff32"><label>32</label>Department of Psychiatry, University of Iceland, National University Hospital, Hringbraut, IS-101 Reykjavík, Iceland</aff><aff id="aff33"><label>33</label>CNS Division, deCODE Genetics, Sturlugata 8, IS-101 Reykjavík, Iceland</aff><aff id="aff34"><label>34</label>School of Medicine, University of Iceland, IS-101 Reykjavik, Iceland</aff><aff id="aff35"><label>35</label>Laboratory for Human Genetics, INGEB, University of Sarajevo, BA-71000 Sarajevo, Bosnia and Herzegovina</aff><aff id="aff36"><label>36</label>Psychiatric Clinic, Clinical Center, University of Sarajevo, BA-71000 Sarajevo, Bosnia and Herzegovina</aff><aff id="aff37"><label>37</label>Civil Hospital Carlos Haya, ES-29010 Málaga, Spain</aff><aff id="aff38"><label>38</label>Institute of Pulmonology, Russian State Medical University, 105077 Moscow, Russia</aff><aff id="aff39"><label>39</label>Russian Academy of Medical Sciences, Mental Health Research Center, 115522 Moscow, Russia</aff><aff id="aff40"><label>40</label>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, RO-041914 Bucharest, Romania</aff><aff id="aff41"><label>41</label>Stefan S. Nicolau Institute of Virology, Romanian Academy, RO-030304 Bucharest, Romania</aff><aff id="aff42"><label>42</label>Department of Psychiatry, Poznan University of Medical Sciences, PL-60-572 Poznan, Poland</aff><aff id="aff43"><label>43</label>Department of Psychiatry and Psychotherapy, University Medical Center, University of Göttingen, D-37075 Göttingen, Germany</aff><aff id="aff44"><label>44</label>Department of Psychiatry, University of Bonn, D-53127 Bonn, Germany</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author <email>sven.cichon@uni-bonn.de</email></corresp><fn id="fn1"><label>45</label><p>These authors contributed equally to this work</p></fn></author-notes><pub-date pub-type="ppub"><day>11</day><month>3</month><year>2011</year></pub-date><volume>88</volume><issue>3</issue><fpage>372</fpage><lpage>381</lpage><history><date date-type="received"><day>1</day><month>10</month><year>2010</year></date><date date-type="rev-recd"><day>14</day><month>1</month><year>2011</year></date><date date-type="accepted"><day>29</day><month>1</month><year>2011</year></date></history><permissions><copyright-statement>© 2011 The American Society of Human Genetics. Published by Elsevier Ltd. All right reserved.</copyright-statement><copyright-year>2011</copyright-year><copyright-holder>The American Society of Human Genetics</copyright-holder></permissions><abstract><p>We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar disorder (BD), a common neuropsychiatric disorder. In the GWAS, we investigated 499,494 autosomal and 12,484 X-chromosomal SNPs in 682 patients with BD and in 1300 controls. In the first follow-up step, we tested the most significant 48 SNPs in 1729 patients with BD and in 2313 controls. Eight SNPs showed nominally significant association with BD and were introduced to a meta-analysis of the GWAS and the first follow-up samples. Genetic variation in the neurocan gene (<italic>NCAN</italic>) showed genome-wide significant association with BD in 2411 patients and 3613 controls (rs1064395, p = 3.02 × 10<sup>−8</sup>; odds ratio = 1.31). In a second follow-up step, we replicated this finding in independent samples of BD, totaling 6030 patients and 31,749 controls (p = 2.74 × 10<sup>−4</sup>; odds ratio = 1.12). The combined analysis of all study samples yielded a p value of 2.14 × 10<sup>−9</sup> (odds ratio = 1.17). Our results provide evidence that rs1064395 is a common risk factor for BD. <italic>NCAN</italic> encodes neurocan, an extracellular matrix glycoprotein, which is thought to be involved in cell adhesion and migration. We found that expression in mice is localized within cortical and hippocampal areas. These areas are involved in cognition and emotion regulation and have previously been implicated in BD by neuropsychological, neuroimaging, and postmortem studies.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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