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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions</title><author><name sortKey="Aziz, Athar" sort="Aziz, Athar" uniqKey="Aziz A" first="Athar" last="Aziz">Athar Aziz</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Baxter, E Joanna" sort="Baxter, E Joanna" uniqKey="Baxter E" first="E Joanna" last="Baxter">E Joanna Baxter</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Edwards, Carol" sort="Edwards, Carol" uniqKey="Edwards C" first="Carol" last="Edwards">Carol Edwards</name><affiliation><nlm:aff id="I4">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Cheong, Clara Yujing" sort="Cheong, Clara Yujing" uniqKey="Cheong C" first="Clara Yujing" last="Cheong">Clara Yujing Cheong</name><affiliation><nlm:aff id="I5">A*STAR Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ito, Mitsuteru" sort="Ito, Mitsuteru" uniqKey="Ito M" first="Mitsuteru" last="Ito">Mitsuteru Ito</name><affiliation><nlm:aff id="I4">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Bench, Anthony" sort="Bench, Anthony" uniqKey="Bench A" first="Anthony" last="Bench">Anthony Bench</name><affiliation><nlm:aff id="I3">Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kelley, Rebecca" sort="Kelley, Rebecca" uniqKey="Kelley R" first="Rebecca" last="Kelley">Rebecca Kelley</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Silber, Yvonne" sort="Silber, Yvonne" uniqKey="Silber Y" first="Yvonne" last="Silber">Yvonne Silber</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Beer, Philip A" sort="Beer, Philip A" uniqKey="Beer P" first="Philip A" last="Beer">Philip A. Beer</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chng, Keefe" sort="Chng, Keefe" uniqKey="Chng K" first="Keefe" last="Chng">Keefe Chng</name><affiliation><nlm:aff id="I5">A*STAR Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, Singapore</nlm:aff></affiliation></author><author><name sortKey="Renfree, Marilyn B" sort="Renfree, Marilyn B" uniqKey="Renfree M" first="Marilyn B" last="Renfree">Marilyn B. Renfree</name><affiliation><nlm:aff id="I6">Department of Zoology, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Mcewen, Kirsten" sort="Mcewen, Kirsten" uniqKey="Mcewen K" first="Kirsten" last="Mcewen">Kirsten Mcewen</name><affiliation><nlm:aff id="I4">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Gray, Dionne" sort="Gray, Dionne" uniqKey="Gray D" first="Dionne" last="Gray">Dionne Gray</name><affiliation><nlm:aff id="I4">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Nangalia, Jyoti" sort="Nangalia, Jyoti" uniqKey="Nangalia J" first="Jyoti" last="Nangalia">Jyoti Nangalia</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Mufti, Ghulam J" sort="Mufti, Ghulam J" uniqKey="Mufti G" first="Ghulam J" last="Mufti">Ghulam J. Mufti</name><affiliation><nlm:aff id="I7">Department of Hematological Medicine, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Hellstrom Lindberg, Eva" sort="Hellstrom Lindberg, Eva" uniqKey="Hellstrom Lindberg E" first="Eva" last="Hellstrom-Lindberg">Eva Hellstrom-Lindberg</name><affiliation><nlm:aff id="I8">Karolinska Institute, Department of Medicine, Division of Hematology, Karolinska University Hospital Huddinge, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kiladjian, Jean Jacques" sort="Kiladjian, Jean Jacques" uniqKey="Kiladjian J" first="Jean-Jacques" last="Kiladjian">Jean-Jacques Kiladjian</name><affiliation><nlm:aff id="I9">Hopital Saint-Louis, AP-HP, Centre d’Investigations Cliniques, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="I10">Université Paris 7 Denis Diderot, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mcmullin, Mary Frances" sort="Mcmullin, Mary Frances" uniqKey="Mcmullin M" first="Mary Frances" last="Mcmullin">Mary Frances Mcmullin</name><affiliation><nlm:aff id="I11">Center for Cancer Research and Cell Biology, Queen’s University, Belfast, UK</nlm:aff></affiliation></author><author><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I12">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ferguson Smith, Anne C" sort="Ferguson Smith, Anne C" uniqKey="Ferguson Smith A" first="Anne C" last="Ferguson-Smith">Anne C. Ferguson-Smith</name><affiliation><nlm:aff id="I4">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Green, Anthony R" sort="Green, Anthony R" uniqKey="Green A" first="Anthony R" last="Green">Anthony R. Green</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">3751516</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751516</idno><idno type="RBID">PMC:3751516</idno><idno type="doi">10.1186/1868-7083-5-S1-S5</idno><idno type="pmid">NONE</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001153</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001153</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions</title><author><name sortKey="Aziz, Athar" sort="Aziz, Athar" uniqKey="Aziz A" first="Athar" last="Aziz">Athar Aziz</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Baxter, E Joanna" sort="Baxter, E Joanna" uniqKey="Baxter E" first="E Joanna" last="Baxter">E Joanna Baxter</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Edwards, Carol" sort="Edwards, Carol" uniqKey="Edwards C" first="Carol" last="Edwards">Carol Edwards</name><affiliation><nlm:aff id="I4">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Cheong, Clara Yujing" sort="Cheong, Clara Yujing" uniqKey="Cheong C" first="Clara Yujing" last="Cheong">Clara Yujing Cheong</name><affiliation><nlm:aff id="I5">A*STAR Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ito, Mitsuteru" sort="Ito, Mitsuteru" uniqKey="Ito M" first="Mitsuteru" last="Ito">Mitsuteru Ito</name><affiliation><nlm:aff id="I4">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Bench, Anthony" sort="Bench, Anthony" uniqKey="Bench A" first="Anthony" last="Bench">Anthony Bench</name><affiliation><nlm:aff id="I3">Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kelley, Rebecca" sort="Kelley, Rebecca" uniqKey="Kelley R" first="Rebecca" last="Kelley">Rebecca Kelley</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Silber, Yvonne" sort="Silber, Yvonne" uniqKey="Silber Y" first="Yvonne" last="Silber">Yvonne Silber</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Beer, Philip A" sort="Beer, Philip A" uniqKey="Beer P" first="Philip A" last="Beer">Philip A. Beer</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chng, Keefe" sort="Chng, Keefe" uniqKey="Chng K" first="Keefe" last="Chng">Keefe Chng</name><affiliation><nlm:aff id="I5">A*STAR Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, Singapore</nlm:aff></affiliation></author><author><name sortKey="Renfree, Marilyn B" sort="Renfree, Marilyn B" uniqKey="Renfree M" first="Marilyn B" last="Renfree">Marilyn B. Renfree</name><affiliation><nlm:aff id="I6">Department of Zoology, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Mcewen, Kirsten" sort="Mcewen, Kirsten" uniqKey="Mcewen K" first="Kirsten" last="Mcewen">Kirsten Mcewen</name><affiliation><nlm:aff id="I4">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Gray, Dionne" sort="Gray, Dionne" uniqKey="Gray D" first="Dionne" last="Gray">Dionne Gray</name><affiliation><nlm:aff id="I4">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Nangalia, Jyoti" sort="Nangalia, Jyoti" uniqKey="Nangalia J" first="Jyoti" last="Nangalia">Jyoti Nangalia</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Mufti, Ghulam J" sort="Mufti, Ghulam J" uniqKey="Mufti G" first="Ghulam J" last="Mufti">Ghulam J. Mufti</name><affiliation><nlm:aff id="I7">Department of Hematological Medicine, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Hellstrom Lindberg, Eva" sort="Hellstrom Lindberg, Eva" uniqKey="Hellstrom Lindberg E" first="Eva" last="Hellstrom-Lindberg">Eva Hellstrom-Lindberg</name><affiliation><nlm:aff id="I8">Karolinska Institute, Department of Medicine, Division of Hematology, Karolinska University Hospital Huddinge, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kiladjian, Jean Jacques" sort="Kiladjian, Jean Jacques" uniqKey="Kiladjian J" first="Jean-Jacques" last="Kiladjian">Jean-Jacques Kiladjian</name><affiliation><nlm:aff id="I9">Hopital Saint-Louis, AP-HP, Centre d’Investigations Cliniques, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="I10">Université Paris 7 Denis Diderot, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mcmullin, Mary Frances" sort="Mcmullin, Mary Frances" uniqKey="Mcmullin M" first="Mary Frances" last="Mcmullin">Mary Frances Mcmullin</name><affiliation><nlm:aff id="I11">Center for Cancer Research and Cell Biology, Queen’s University, Belfast, UK</nlm:aff></affiliation></author><author><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I12">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ferguson Smith, Anne C" sort="Ferguson Smith, Anne C" uniqKey="Ferguson Smith A" first="Anne C" last="Ferguson-Smith">Anne C. Ferguson-Smith</name><affiliation><nlm:aff id="I4">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Green, Anthony R" sort="Green, Anthony R" uniqKey="Green A" first="Anthony R" last="Green">Anthony R. Green</name><affiliation><nlm:aff id="I1">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Department of Hematology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Clinical Epigenetics</title><idno type="ISSN">1868-7075</idno><idno type="eISSN">1868-7083</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Epigenetics</journal-id><journal-id journal-id-type="iso-abbrev">Clin Epigenetics</journal-id><journal-title-group><journal-title>Clinical Epigenetics</journal-title></journal-title-group><issn pub-type="ppub">1868-7075</issn><issn pub-type="epub">1868-7083</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">3751516</article-id><article-id pub-id-type="publisher-id">1868-7083-5-S1-S5</article-id><article-id pub-id-type="doi">10.1186/1868-7083-5-S1-S5</article-id><article-categories><subj-group subj-group-type="heading"><subject>Meeting Abstract</subject></subj-group></article-categories><title-group><article-title>Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions</article-title></title-group><contrib-group><contrib contrib-type="author" id="A1"><name><surname>Aziz</surname><given-names>Athar</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref></contrib><contrib contrib-type="author" id="A2"><name><surname>Baxter</surname><given-names>E Joanna</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref></contrib><contrib contrib-type="author" id="A3"><name><surname>Edwards</surname><given-names>Carol</given-names></name><xref ref-type="aff" rid="I4">4</xref></contrib><contrib contrib-type="author" id="A4"><name><surname>Cheong</surname><given-names>Clara Yujing</given-names></name><xref ref-type="aff" rid="I5">5</xref></contrib><contrib contrib-type="author" id="A5"><name><surname>Ito</surname><given-names>Mitsuteru</given-names></name><xref ref-type="aff" rid="I4">4</xref></contrib><contrib contrib-type="author" id="A6"><name><surname>Bench</surname><given-names>Anthony</given-names></name><xref ref-type="aff" rid="I3">3</xref></contrib><contrib contrib-type="author" id="A7"><name><surname>Kelley</surname><given-names>Rebecca</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref></contrib><contrib contrib-type="author" id="A8"><name><surname>Silber</surname><given-names>Yvonne</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref></contrib><contrib contrib-type="author" id="A9"><name><surname>Beer</surname><given-names>Philip A</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref></contrib><contrib contrib-type="author" id="A10"><name><surname>Chng</surname><given-names>Keefe</given-names></name><xref ref-type="aff" rid="I5">5</xref></contrib><contrib contrib-type="author" id="A11"><name><surname>Renfree</surname><given-names>Marilyn B</given-names></name><xref ref-type="aff" rid="I6">6</xref></contrib><contrib contrib-type="author" id="A12"><name><surname>McEwen</surname><given-names>Kirsten</given-names></name><xref ref-type="aff" rid="I4">4</xref></contrib><contrib contrib-type="author" id="A13"><name><surname>Gray</surname><given-names>Dionne</given-names></name><xref ref-type="aff" rid="I4">4</xref></contrib><contrib contrib-type="author" id="A14"><name><surname>Nangalia</surname><given-names>Jyoti</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref></contrib><contrib contrib-type="author" id="A15"><name><surname>Mufti</surname><given-names>Ghulam J</given-names></name><xref ref-type="aff" rid="I7">7</xref></contrib><contrib contrib-type="author" id="A16"><name><surname>Hellstrom-Lindberg</surname><given-names>Eva</given-names></name><xref ref-type="aff" rid="I8">8</xref></contrib><contrib contrib-type="author" id="A17"><name><surname>Kiladjian</surname><given-names>Jean-Jacques</given-names></name><xref ref-type="aff" rid="I9">9</xref><xref ref-type="aff" rid="I10">10</xref></contrib><contrib contrib-type="author" id="A18"><name><surname>McMullin</surname><given-names>Mary Frances</given-names></name><xref ref-type="aff" rid="I11">11</xref></contrib><contrib contrib-type="author" id="A19"><name><surname>Campbell</surname><given-names>Peter J</given-names></name><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref><xref ref-type="aff" rid="I12">12</xref></contrib><contrib contrib-type="author" id="A20"><name><surname>Ferguson-Smith</surname><given-names>Anne C</given-names></name><xref ref-type="aff" rid="I4">4</xref></contrib><contrib contrib-type="author" corresp="yes" id="A21"><name><surname>Green</surname><given-names>Anthony R</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref></contrib></contrib-group><aff id="I1"><label>1</label>Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, UK</aff><aff id="I2"><label>2</label>Department of Hematology, University of Cambridge, Cambridge, UK</aff><aff id="I3"><label>3</label>Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK</aff><aff id="I4"><label>4</label>Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK</aff><aff id="I5"><label>5</label>A*STAR Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, Singapore</aff><aff id="I6"><label>6</label>Department of Zoology, University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="I7"><label>7</label>Department of Hematological Medicine, King’s College London, London, UK</aff><aff id="I8"><label>8</label>Karolinska Institute, Department of Medicine, Division of Hematology, Karolinska University Hospital Huddinge, Stockholm, Sweden</aff><aff id="I9"><label>9</label>Hopital Saint-Louis, AP-HP, Centre d’Investigations Cliniques, Paris, France</aff><aff id="I10"><label>10</label>Université Paris 7 Denis Diderot, Paris, France</aff><aff id="I11"><label>11</label>Center for Cancer Research and Cell Biology, Queen’s University, Belfast, UK</aff><aff id="I12"><label>12</label>Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>19</day><month>8</month><year>2013</year></pub-date><volume>5</volume><issue>Suppl 1</issue><supplement><named-content content-type="supplement-title">Proceedings of the Birmingham Cancer Epigenetics Conference; Translational Opportunities</named-content><named-content content-type="supplement-editor">Ciaran Woodman, Bryan Turner, Constanze Bonnifer, Jennifer Anderton, Sarah Leonard and Lynn Thompson</named-content></supplement><fpage>S5</fpage><lpage>S5</lpage><permissions><copyright-statement>Copyright © 2013 Aziz et al; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>Aziz et al; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.clinicalepigeneticsjournal.com/content/5/S1/S5"></self-uri><conference><conf-date><day>16</day><month>5</month><year>2013</year></conf-date><conf-name>Birminghm Cancer Epigenetics Conference; Translational Opportunities</conf-name><conf-loc>Birmingham, UK</conf-loc></conference></article-meta></front><body><sec><title></title><p>Large regions of recurrent genomic loss are common in cancers; however, with a few well-characterized exceptions, how they contribute to tumor pathogenesis remains largely obscure. Here we identified primate-restricted imprinting of a gene cluster on chromosome 20 in the region commonly deleted in chronic myeloid malignancies. We showed that a single heterozygous 20q deletion consistently resulted in the complete loss of expression of the imprinted genes L3MBTL1 and SGK2, indicative of a pathogenetic role for loss of the active paternally inherited locus. Concomitant loss of both L3MBTL1 and SGK2 dysregulated erythropoiesis and megakaryopoiesis, 2 lineages commonly affected in chronic myeloid malignancies, with distinct consequences in each lineage. We demonstrated that L3MBTL1 and SGK2 collaborated in the transcriptional regulation of MYC by influencing different aspects of chromatin structure. L3MBTL1 is known to regulate nucleosomal compaction, and we here showed that SGK2 inactivated BRG1, a key ATP-dependent helicase within the SWI/SNF complex that regulates nucleosomal positioning. These results demonstrate a link between an imprinted gene cluster and malignancy, reveal a new pathogenetic mechanism associated with acquired regions of genomic loss, and underline the complex molecular and cellular consequences of "simple" cancer-associated chromosome deletions.</p></sec></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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