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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Flowcharts for the diagnosis and treatment of acute cholangitis and cholecystitis: Tokyo Guidelines</title><author><name sortKey="Miura, Fumihiko" sort="Miura, Fumihiko" uniqKey="Miura F" first="Fumihiko" last="Miura">Fumihiko Miura</name><affiliation><nlm:aff id="A1">Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-Ku, Tokyo, 173-8605 Japan</nlm:aff></affiliation></author><author><name sortKey="Takada, Tadahiro" sort="Takada, Tadahiro" uniqKey="Takada T" first="Tadahiro" last="Takada">Tadahiro Takada</name><affiliation><nlm:aff id="A1">Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-Ku, Tokyo, 173-8605 Japan</nlm:aff></affiliation></author><author><name sortKey="Kawarada, Yoshifumi" sort="Kawarada, Yoshifumi" uniqKey="Kawarada Y" first="Yoshifumi" last="Kawarada">Yoshifumi Kawarada</name><affiliation><nlm:aff id="A2">Mie University School of Medicine, Mie, Japan</nlm:aff></affiliation></author><author><name sortKey="Nimura, Yuji" sort="Nimura, Yuji" uniqKey="Nimura Y" first="Yuji" last="Nimura">Yuji Nimura</name><affiliation><nlm:aff id="A3">Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Wada, Keita" sort="Wada, Keita" uniqKey="Wada K" first="Keita" last="Wada">Keita Wada</name><affiliation><nlm:aff id="A1">Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-Ku, Tokyo, 173-8605 Japan</nlm:aff></affiliation></author><author><name sortKey="Hirota, Masahiko" sort="Hirota, Masahiko" uniqKey="Hirota M" first="Masahiko" last="Hirota">Masahiko Hirota</name><affiliation><nlm:aff id="A4">Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Science, Kumamoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Nagino, Masato" sort="Nagino, Masato" uniqKey="Nagino M" first="Masato" last="Nagino">Masato Nagino</name><affiliation><nlm:aff id="A3">Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Tsuyuguchi, Toshio" sort="Tsuyuguchi, Toshio" uniqKey="Tsuyuguchi T" first="Toshio" last="Tsuyuguchi">Toshio Tsuyuguchi</name><affiliation><nlm:aff id="A5">Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan</nlm:aff></affiliation></author><author><name sortKey="Mayumi, Toshihiko" sort="Mayumi, Toshihiko" uniqKey="Mayumi T" first="Toshihiko" last="Mayumi">Toshihiko Mayumi</name><affiliation><nlm:aff id="A6">Department of Emergency Medicine and Critical Care, Nagoya University School of Medicine, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Yoshida, Masahiro" sort="Yoshida, Masahiro" uniqKey="Yoshida M" first="Masahiro" last="Yoshida">Masahiro Yoshida</name><affiliation><nlm:aff id="A1">Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-Ku, Tokyo, 173-8605 Japan</nlm:aff></affiliation></author><author><name sortKey="Strasberg, Steven M" sort="Strasberg, Steven M" uniqKey="Strasberg S" first="Steven M." last="Strasberg">Steven M. Strasberg</name><affiliation><nlm:aff id="A7">Department of Surgery, Washington University in St Louis and Barnes-Jewish Hospital, St Louis, USA</nlm:aff></affiliation></author><author><name sortKey="Pitt, Henry A" sort="Pitt, Henry A" uniqKey="Pitt H" first="Henry A." last="Pitt">Henry A. Pitt</name><affiliation><nlm:aff id="A8">Department of Surgery, Indiana University School of Medicine, Indianapolis, USA</nlm:aff></affiliation></author><author><name sortKey="Belghiti, Jacques" sort="Belghiti, Jacques" uniqKey="Belghiti J" first="Jacques" last="Belghiti">Jacques Belghiti</name><affiliation><nlm:aff id="A9">Department of Digestive Surgery and Transplantation, Hospital Beaujon, Clichy, France</nlm:aff></affiliation></author><author><name sortKey="De Santibanes, Eduardo" sort="De Santibanes, Eduardo" uniqKey="De Santibanes E" first="Eduardo" last="De Santibanes">Eduardo De Santibanes</name><affiliation><nlm:aff id="A10">Department of Surgery, University of Buenos Aires, Buenos Aires, Argentina</nlm:aff></affiliation></author><author><name sortKey="Gadacz, Thomas R" sort="Gadacz, Thomas R" uniqKey="Gadacz T" first="Thomas R." last="Gadacz">Thomas R. Gadacz</name><affiliation><nlm:aff id="A11">Department of Gastrointestinal Surgery, Medical College of Georgia, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Gouma, Dirk J" sort="Gouma, Dirk J" uniqKey="Gouma D" first="Dirk J." last="Gouma">Dirk J. Gouma</name><affiliation><nlm:aff id="A12">Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Fan, Sheung Tat" sort="Fan, Sheung Tat" uniqKey="Fan S" first="Sheung-Tat" last="Fan">Sheung-Tat Fan</name><affiliation><nlm:aff id="A13">Department of Surgery, The University of Hong Kong, Pokfulam Hong Kong, China</nlm:aff></affiliation></author><author><name sortKey="Chen, Miin Fu" sort="Chen, Miin Fu" uniqKey="Chen M" first="Miin-Fu" last="Chen">Miin-Fu Chen</name><affiliation><nlm:aff id="A14">Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Padbury, Robert T" sort="Padbury, Robert T" uniqKey="Padbury R" first="Robert T." last="Padbury">Robert T. Padbury</name><affiliation><nlm:aff id="A15">Division of Surgical and Specialty Services, Flinders Medical Centre, Adelaide, Australia</nlm:aff></affiliation></author><author><name sortKey="Bornman, Philippus C" sort="Bornman, Philippus C" uniqKey="Bornman P" first="Philippus C." last="Bornman">Philippus C. Bornman</name><affiliation><nlm:aff id="A16">Division of General Surgery, University of Cape Town, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Kim, Sun Whe" sort="Kim, Sun Whe" uniqKey="Kim S" first="Sun-Whe" last="Kim">Sun-Whe Kim</name><affiliation><nlm:aff id="A17">Department of Surgery, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Liau, Kui Hin" sort="Liau, Kui Hin" uniqKey="Liau K" first="Kui-Hin" last="Liau">Kui-Hin Liau</name><affiliation><nlm:aff id="A18">Department of Surgery, Tan Tock Seng Hospital / Hepatobiliary Surgery, Medical Centre, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Belli, Giulio" sort="Belli, Giulio" uniqKey="Belli G" first="Giulio" last="Belli">Giulio Belli</name><affiliation><nlm:aff id="A19">Department of General and Hepato-Pancreato-Biliary Surgery, S.M. Loreto Nuovo Hospital, Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Dervenis, Christos" sort="Dervenis, Christos" uniqKey="Dervenis C" first="Christos" last="Dervenis">Christos Dervenis</name><affiliation><nlm:aff id="A20">First Department of Surgery, Agia Olga Hospital, Athens, Greece</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17252294</idno><idno type="pmc">2784508</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784508</idno><idno type="RBID">PMC:2784508</idno><idno type="doi">10.1007/s00534-006-1153-x</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">001145</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001145</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Flowcharts for the diagnosis and treatment of acute cholangitis and cholecystitis: Tokyo Guidelines</title><author><name sortKey="Miura, Fumihiko" sort="Miura, Fumihiko" uniqKey="Miura F" first="Fumihiko" last="Miura">Fumihiko Miura</name><affiliation><nlm:aff id="A1">Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-Ku, Tokyo, 173-8605 Japan</nlm:aff></affiliation></author><author><name sortKey="Takada, Tadahiro" sort="Takada, Tadahiro" uniqKey="Takada T" first="Tadahiro" last="Takada">Tadahiro Takada</name><affiliation><nlm:aff id="A1">Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-Ku, Tokyo, 173-8605 Japan</nlm:aff></affiliation></author><author><name sortKey="Kawarada, Yoshifumi" sort="Kawarada, Yoshifumi" uniqKey="Kawarada Y" first="Yoshifumi" last="Kawarada">Yoshifumi Kawarada</name><affiliation><nlm:aff id="A2">Mie University School of Medicine, Mie, Japan</nlm:aff></affiliation></author><author><name sortKey="Nimura, Yuji" sort="Nimura, Yuji" uniqKey="Nimura Y" first="Yuji" last="Nimura">Yuji Nimura</name><affiliation><nlm:aff id="A3">Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Wada, Keita" sort="Wada, Keita" uniqKey="Wada K" first="Keita" last="Wada">Keita Wada</name><affiliation><nlm:aff id="A1">Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-Ku, Tokyo, 173-8605 Japan</nlm:aff></affiliation></author><author><name sortKey="Hirota, Masahiko" sort="Hirota, Masahiko" uniqKey="Hirota M" first="Masahiko" last="Hirota">Masahiko Hirota</name><affiliation><nlm:aff id="A4">Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Science, Kumamoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Nagino, Masato" sort="Nagino, Masato" uniqKey="Nagino M" first="Masato" last="Nagino">Masato Nagino</name><affiliation><nlm:aff id="A3">Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Tsuyuguchi, Toshio" sort="Tsuyuguchi, Toshio" uniqKey="Tsuyuguchi T" first="Toshio" last="Tsuyuguchi">Toshio Tsuyuguchi</name><affiliation><nlm:aff id="A5">Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan</nlm:aff></affiliation></author><author><name sortKey="Mayumi, Toshihiko" sort="Mayumi, Toshihiko" uniqKey="Mayumi T" first="Toshihiko" last="Mayumi">Toshihiko Mayumi</name><affiliation><nlm:aff id="A6">Department of Emergency Medicine and Critical Care, Nagoya University School of Medicine, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Yoshida, Masahiro" sort="Yoshida, Masahiro" uniqKey="Yoshida M" first="Masahiro" last="Yoshida">Masahiro Yoshida</name><affiliation><nlm:aff id="A1">Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-Ku, Tokyo, 173-8605 Japan</nlm:aff></affiliation></author><author><name sortKey="Strasberg, Steven M" sort="Strasberg, Steven M" uniqKey="Strasberg S" first="Steven M." last="Strasberg">Steven M. Strasberg</name><affiliation><nlm:aff id="A7">Department of Surgery, Washington University in St Louis and Barnes-Jewish Hospital, St Louis, USA</nlm:aff></affiliation></author><author><name sortKey="Pitt, Henry A" sort="Pitt, Henry A" uniqKey="Pitt H" first="Henry A." last="Pitt">Henry A. Pitt</name><affiliation><nlm:aff id="A8">Department of Surgery, Indiana University School of Medicine, Indianapolis, USA</nlm:aff></affiliation></author><author><name sortKey="Belghiti, Jacques" sort="Belghiti, Jacques" uniqKey="Belghiti J" first="Jacques" last="Belghiti">Jacques Belghiti</name><affiliation><nlm:aff id="A9">Department of Digestive Surgery and Transplantation, Hospital Beaujon, Clichy, France</nlm:aff></affiliation></author><author><name sortKey="De Santibanes, Eduardo" sort="De Santibanes, Eduardo" uniqKey="De Santibanes E" first="Eduardo" last="De Santibanes">Eduardo De Santibanes</name><affiliation><nlm:aff id="A10">Department of Surgery, University of Buenos Aires, Buenos Aires, Argentina</nlm:aff></affiliation></author><author><name sortKey="Gadacz, Thomas R" sort="Gadacz, Thomas R" uniqKey="Gadacz T" first="Thomas R." last="Gadacz">Thomas R. Gadacz</name><affiliation><nlm:aff id="A11">Department of Gastrointestinal Surgery, Medical College of Georgia, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Gouma, Dirk J" sort="Gouma, Dirk J" uniqKey="Gouma D" first="Dirk J." last="Gouma">Dirk J. Gouma</name><affiliation><nlm:aff id="A12">Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Fan, Sheung Tat" sort="Fan, Sheung Tat" uniqKey="Fan S" first="Sheung-Tat" last="Fan">Sheung-Tat Fan</name><affiliation><nlm:aff id="A13">Department of Surgery, The University of Hong Kong, Pokfulam Hong Kong, China</nlm:aff></affiliation></author><author><name sortKey="Chen, Miin Fu" sort="Chen, Miin Fu" uniqKey="Chen M" first="Miin-Fu" last="Chen">Miin-Fu Chen</name><affiliation><nlm:aff id="A14">Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Padbury, Robert T" sort="Padbury, Robert T" uniqKey="Padbury R" first="Robert T." last="Padbury">Robert T. Padbury</name><affiliation><nlm:aff id="A15">Division of Surgical and Specialty Services, Flinders Medical Centre, Adelaide, Australia</nlm:aff></affiliation></author><author><name sortKey="Bornman, Philippus C" sort="Bornman, Philippus C" uniqKey="Bornman P" first="Philippus C." last="Bornman">Philippus C. Bornman</name><affiliation><nlm:aff id="A16">Division of General Surgery, University of Cape Town, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Kim, Sun Whe" sort="Kim, Sun Whe" uniqKey="Kim S" first="Sun-Whe" last="Kim">Sun-Whe Kim</name><affiliation><nlm:aff id="A17">Department of Surgery, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Liau, Kui Hin" sort="Liau, Kui Hin" uniqKey="Liau K" first="Kui-Hin" last="Liau">Kui-Hin Liau</name><affiliation><nlm:aff id="A18">Department of Surgery, Tan Tock Seng Hospital / Hepatobiliary Surgery, Medical Centre, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Belli, Giulio" sort="Belli, Giulio" uniqKey="Belli G" first="Giulio" last="Belli">Giulio Belli</name><affiliation><nlm:aff id="A19">Department of General and Hepato-Pancreato-Biliary Surgery, S.M. Loreto Nuovo Hospital, Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Dervenis, Christos" sort="Dervenis, Christos" uniqKey="Dervenis C" first="Christos" last="Dervenis">Christos Dervenis</name><affiliation><nlm:aff id="A20">First Department of Surgery, Agia Olga Hospital, Athens, Greece</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Hepato-Biliary-Pancreatic Surgery</title><idno type="ISSN">0944-1166</idno><idno type="eISSN">1436-0691</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Diagnostic and therapeutic strategies for acute biliary inflammation/infection (acute cholangitis and acute cholecystitis), according to severity grade, have not yet been established in the world. Therefore we formulated flowcharts for the management of acute biliary inflammation/infection in accordance with severity grade. For mild (grade I) acute cholangitis, medical treatment may be sufficient/appropriate. For moderate (grade II) acute cholangitis, early biliary drainage should be performed. For severe (grade III) acute cholangitis, appropriate organ support such as ventilatory/circulatory management is required. After hemodynamic stabilization is achieved, urgent endoscopic or percutaneous transhepatic biliary drainage should be performed. For patients with acute cholangitis of any grade of severity, treatment for the underlying etiology, including endoscopic, percutaneous, or surgical treatment should be performed after the patient’s general condition has improved. For patients with mild (grade I) cholecystitis, early laparoscopic cholecystectomy is the preferred treatment. For patients with moderate (grade II) acute cholecystitis, early laparoscopic or open cholecystectomy is preferred. In patients with extensive local inflammation, elective cholecystectomy is recommended after initial management with percutaneous gallbladder drainage and/or cholecystostomy. For the patient with severe (grade III) acute cholecystitis, multiorgan support is a critical part of management. Biliary peritonitis due to perforation of the gallbladder is an indication for urgent cholecystectomy and/or drainage. Delayed elective cholecystectomy may be performed after initial treatment with gallbladder drainage and improvement of the patient’s general medical condition.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc xml:lang="EN" article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Hepatobiliary Pancreat Surg</journal-id><journal-title>Journal of Hepato-Biliary-Pancreatic Surgery</journal-title><issn pub-type="ppub">0944-1166</issn><issn pub-type="epub">1436-0691</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>Tokyo</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17252294</article-id><article-id pub-id-type="pmc">2784508</article-id><article-id pub-id-type="publisher-id">1153</article-id><article-id pub-id-type="doi">10.1007/s00534-006-1153-x</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Flowcharts for the diagnosis and treatment of acute cholangitis and cholecystitis: Tokyo Guidelines</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Miura</surname><given-names>Fumihiko</given-names></name><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Takada</surname><given-names>Tadahiro</given-names></name><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kawarada</surname><given-names>Yoshifumi</given-names></name><xref ref-type="aff" rid="A2"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Nimura</surname><given-names>Yuji</given-names></name><xref ref-type="aff" rid="A3"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Wada</surname><given-names>Keita</given-names></name><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Hirota</surname><given-names>Masahiko</given-names></name><xref ref-type="aff" rid="A4"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Nagino</surname><given-names>Masato</given-names></name><xref ref-type="aff" rid="A3"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Tsuyuguchi</surname><given-names>Toshio</given-names></name><xref ref-type="aff" rid="A5"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Mayumi</surname><given-names>Toshihiko</given-names></name><xref ref-type="aff" rid="A6"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Yoshida</surname><given-names>Masahiro</given-names></name><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Strasberg</surname><given-names>Steven M.</given-names></name><xref ref-type="aff" rid="A7"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Pitt</surname><given-names>Henry A.</given-names></name><xref ref-type="aff" rid="A8"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Belghiti</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="A9"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>de Santibanes</surname><given-names>Eduardo</given-names></name><xref ref-type="aff" rid="A10"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Gadacz</surname><given-names>Thomas R.</given-names></name><xref ref-type="aff" rid="A11"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Gouma</surname><given-names>Dirk J.</given-names></name><xref ref-type="aff" rid="A12"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Fan</surname><given-names>Sheung-Tat</given-names></name><xref ref-type="aff" rid="A13"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Chen</surname><given-names>Miin-Fu</given-names></name><xref ref-type="aff" rid="A14"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Padbury</surname><given-names>Robert T.</given-names></name><xref ref-type="aff" rid="A15"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Bornman</surname><given-names>Philippus C.</given-names></name><xref ref-type="aff" rid="A16"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kim</surname><given-names>Sun-Whe</given-names></name><xref ref-type="aff" rid="A17"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Liau</surname><given-names>Kui-Hin</given-names></name><xref ref-type="aff" rid="A18"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Belli</surname><given-names>Giulio</given-names></name><xref ref-type="aff" rid="A19"></xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Dervenis</surname><given-names>Christos</given-names></name><xref ref-type="aff" rid="A20"></xref></contrib><aff id="A1"><label></label>Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-Ku, Tokyo, 173-8605 Japan</aff><aff id="A2"><label></label>Mie University School of Medicine, Mie, Japan</aff><aff id="A3"><label></label>Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan</aff><aff id="A4"><label></label>Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Science, Kumamoto, Japan</aff><aff id="A5"><label></label>Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan</aff><aff id="A6"><label></label>Department of Emergency Medicine and Critical Care, Nagoya University School of Medicine, Nagoya, Japan</aff><aff id="A7"><label></label>Department of Surgery, Washington University in St Louis and Barnes-Jewish Hospital, St Louis, USA</aff><aff id="A8"><label></label>Department of Surgery, Indiana University School of Medicine, Indianapolis, USA</aff><aff id="A9"><label></label>Department of Digestive Surgery and Transplantation, Hospital Beaujon, Clichy, France</aff><aff id="A10"><label></label>Department of Surgery, University of Buenos Aires, Buenos Aires, Argentina</aff><aff id="A11"><label></label>Department of Gastrointestinal Surgery, Medical College of Georgia, Georgia, USA</aff><aff id="A12"><label></label>Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands</aff><aff id="A13"><label></label>Department of Surgery, The University of Hong Kong, Pokfulam Hong Kong, China</aff><aff id="A14"><label></label>Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan</aff><aff id="A15"><label></label>Division of Surgical and Specialty Services, Flinders Medical Centre, Adelaide, Australia</aff><aff id="A16"><label></label>Division of General Surgery, University of Cape Town, Cape Town, South Africa</aff><aff id="A17"><label></label>Department of Surgery, Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A18"><label></label>Department of Surgery, Tan Tock Seng Hospital / Hepatobiliary Surgery, Medical Centre, Singapore, Singapore</aff><aff id="A19"><label></label>Department of General and Hepato-Pancreato-Biliary Surgery, S.M. Loreto Nuovo Hospital, Naples, Italy</aff><aff id="A20"><label></label>First Department of Surgery, Agia Olga Hospital, Athens, Greece</aff></contrib-group><pub-date pub-type="epub"><day>30</day><month>01</month><year>2007</year></pub-date><pub-date pub-type="ppub"><month>01</month><year>2007</year></pub-date><volume>14</volume><issue>1</issue><fpage>27</fpage><lpage>34</lpage><history><date date-type="received"><day>31</day><month>05</month><year>2006</year></date><date date-type="accepted"><day>06</day><month>08</month><year>2006</year></date></history><permissions><copyright-statement>© Springer-Verlag Tokyo 2007</copyright-statement></permissions><abstract xml:lang="EN"><p>Diagnostic and therapeutic strategies for acute biliary inflammation/infection (acute cholangitis and acute cholecystitis), according to severity grade, have not yet been established in the world. Therefore we formulated flowcharts for the management of acute biliary inflammation/infection in accordance with severity grade. For mild (grade I) acute cholangitis, medical treatment may be sufficient/appropriate. For moderate (grade II) acute cholangitis, early biliary drainage should be performed. For severe (grade III) acute cholangitis, appropriate organ support such as ventilatory/circulatory management is required. After hemodynamic stabilization is achieved, urgent endoscopic or percutaneous transhepatic biliary drainage should be performed. For patients with acute cholangitis of any grade of severity, treatment for the underlying etiology, including endoscopic, percutaneous, or surgical treatment should be performed after the patient’s general condition has improved. For patients with mild (grade I) cholecystitis, early laparoscopic cholecystectomy is the preferred treatment. For patients with moderate (grade II) acute cholecystitis, early laparoscopic or open cholecystectomy is preferred. In patients with extensive local inflammation, elective cholecystectomy is recommended after initial management with percutaneous gallbladder drainage and/or cholecystostomy. For the patient with severe (grade III) acute cholecystitis, multiorgan support is a critical part of management. Biliary peritonitis due to perforation of the gallbladder is an indication for urgent cholecystectomy and/or drainage. Delayed elective cholecystectomy may be performed after initial treatment with gallbladder drainage and improvement of the patient’s general medical condition.</p></abstract><kwd-group><title>Key words</title><kwd>Cholangitis</kwd><kwd>Acute cholecystitis</kwd><kwd>Cholecystec-tomy</kwd><kwd>Laparoscopic cholecystectomy</kwd><kwd>Biliary</kwd><kwd>Drainage</kwd><kwd>Guidelines</kwd></kwd-group><custom-meta-wrap><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer-Verlag Tokyo 2007</meta-value></custom-meta></custom-meta-wrap></article-meta></front><body><sec id="Sec1" sec-type="introduction"><title>Introduction</title><p>Acute biliary inflammation/infection is classified as either acute cholangitis or acute cholecystitis, and ranges from mild forms that improve with medical treatment to severe forms that require intensive care and urgent intervention. The medical condition of a patient with biliary inflammation/infection is likely to deteriorate rapidly and the condition can become life-threatening. Early diagnosis should be made based on clinical signs/symptoms and laboratory findings. The type and timing of treatment should be based on the grade of severity of the disease.</p><p>Although endoscopic and laparoscopic techniques have advanced recently (level 1b–2b),<xref ref-type="bibr" rid="CR1">1</xref>,<xref ref-type="bibr" rid="CR2">2</xref> the treatment of severe acute biliary inflammation/infection still results in fatalities and increased hospital costs. To our knowledge, there are no definite diagnostic and therapeutic guidelines for acute biliary inflammation/infection according to the grade of severity of the disease. This article describes the management strategy for biliary inflammation/infection in accordance with the severity of the biliary disease. Guidelines were developed, based on best clinical evidence and discussions at the International Consensus Meeting held in Tokyo on April 1–2, 2006.</p></sec><sec id="Sec2"><title>General guidance for the management of acute biliary inflammation/infection</title><p>A flowchart showing general guidance for the management of acute biliary inflammation/infection is presented in Fig. <xref rid="Fig1" ref-type="fig">1</xref>.
<fig id="Fig1"><label>Fig. 1</label><caption><p>Flowchart showing general guidance for the management of acute biliary infection</p></caption><graphic position="anchor" xlink:href="534_2006_Article_1153_Fig1" id="MO1"></graphic></fig></p><sec id="Sec3"><title>Clinical presentation</title><p>Clinical findings associated with acute cholangitis include abdominal pain, jaundice, fever (Charcot’s triad), and rigor. The triad was already reported as an indicator of hepatic fever by Charcot in 1877,<xref ref-type="bibr" rid="CR3">3</xref> and has been, historically, used as the generally accepted clinical findings of acute cholangitis. About 50%–70% of patients with acute cholangitis develop all three symptoms (level 2b-4).<xref ref-type="bibr" rid="CR4">4</xref>–<xref ref-type="bibr" rid="CR7">7</xref> Reynolds’ pentad (Charcot’s triad plus shock and a decreased level of consciousness) was presented in 1959, when Reynolds and Dargan<xref ref-type="bibr" rid="CR8">8</xref> defined acute obstructive cholangitis. The pentad is often used to indicate severe (grade III) cholangitis, but shock and a decreased level of consciousness are observed in only 30% or fewer patients with acute cholangitis (level 2b-4).<xref ref-type="bibr" rid="CR4">4</xref>–<xref ref-type="bibr" rid="CR7">7</xref> A history of biliary disease, such as gallstones, previous biliary procedures, or the placement of a biliary stent are factors that are very helpful to suggest a diagnosis of acute cholangitis.</p><p>Clinical symptoms of acute cholecystitis include abdominal pain (right upper abdominal pain), nausea, vomiting, and fever (level 2b-4).<xref ref-type="bibr" rid="CR9">9</xref>–<xref ref-type="bibr" rid="CR11">11</xref> The most typical symptom is right epigastric pain. Tenderness in the right upper abdomen, a palpable gallbladder, and Murphy’s sign are the characteristic findings of acute cholecystitis. A positive Murphy’s sign has a specificity of 79%–96% (level 2b–3b)<xref ref-type="bibr" rid="CR9">9</xref>,<xref ref-type="bibr" rid="CR11">11</xref> for acute cholecystitis.</p></sec><sec id="Sec4"><title>Blood tests</title><p>The diagnosis of acute cholangitis requires a white blood cell count; measurement of the C-reactive protein level; and liver function tests, including alkaline phosphatase, gamma-glutamyltranspeptidase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and bilirubin. Assessment of the severity of the illness requires knowledge of the platelet count, blood urea nitrogen, creatinine, and prothrombin time (PT). Blood cultures are also helpful for severity assessment, as well as for the selection of antimicrobial drugs. Hyperamylasemia is a useful parameter to identify complications such as choledocholithiasis causing biliary pancreatitis (level 1a).<xref ref-type="bibr" rid="CR12">12</xref></p><p>There is no specific blood test for acute cholecystitis; however, the white blood cell count and the measurement of C-reactive protein is very useful in confirming an inflammatory process. Bilirubin, blood urea nitrogen, creatinine, and PT are very useful in assessing the disease severity status of the patient.</p></sec><sec id="Sec5"><title>Diagnostic imaging</title><p>Abdominal ultrasound (US) and abdominal computerized tomography (CT) with intravenous contrast are very helpful studies in evaluating patients with acute biliary tract disease. Abdominal US should be performed in all patients suspected of having acute biliary inflammation/infection. Ultrasound examination has satisfactory diagnostic capability when it is performed not only by specialists but also by emergency physicians (level 1b).<xref ref-type="bibr" rid="CR13">13</xref>,<xref ref-type="bibr" rid="CR14">14</xref></p><p>The role of diagnostic imaging in acute cholangitis is to determine the presence/absence of biliary obstruction, the level of the obstruction, and the cause of the obstruction, such as gallstones and/or biliary strictures. Assessment should include both US and CT. These studies complement each other and CT may better demonstrate dilatation of the bile duct and pneumobilia.</p><p>Some of the characteristic finding of acute cholecystitis include an enlarged gallbladder, thickened gallbladder wall, gallbladder stones and/or debris in the gallbladder, sonographic Murphy’s sign, pericholecystic fluid, and pericholecystic abscess. Sonographic Murphy’s sign is a very reliable finding of acute cholecystitis, with a specificity exceeding 90% (level 3b,4).<xref ref-type="bibr" rid="CR15">15</xref>,<xref ref-type="bibr" rid="CR16">16</xref> CT scan or even plain X-ray may demonstrate free air, pneumobilia, and ileus.</p></sec><sec id="Sec6"><title>Differential diagnosis</title><p>Diseases which should be differentiated from acute cholangitis are acute cholecystitis, gastric and duodenal ulcer, acute pancreatitis, acute hepatitis, and septicemia of other origins. Diseases which should be differentiated from acute cholecystitis are gastric and duodenal ulcer, hepatitis, pancreatitis, gallbladder cancer, hepatic abscess, Fitz-Hugh-Curtis syndrome, right lower lobar pneumonia, angina pectoris, myocardial infarction, and urinary infection.</p></sec></sec><sec id="Sec7"><title>Flowchart for the management of acute cholangitis</title><p>A flowchart for the management of acute cholangitis is shown in Fig. <xref rid="Fig2" ref-type="fig">2</xref>. The treatment of acute cholangitis should be guided by the grade of severity of the disease. Biliary drainage and antibiotics are the two most important elements of treatment. When a diagnosis of acute cholangitis is suspected, medical treatment, including nil per os (NPO) and the use of intravenous fluids, antibiotics, and analgesia, together with close monitoring of blood pressure, pulse, and urinary output should be initiated. Simultaneously, a severity assessment of the cholangitis should be documented, even if it is mild. Frequent reassessment is important, and patients may need to be reclassified as having mild (grade <bold>I</bold>), moderate (grade <bold>II</bold>), or severe (grade <bold>III</bold>) disease, based on the response to medical treatment. Appropriate treatment should be performed in accordance with the severity grade. Patients with concomitant diseases such as acute pancreatitis or malignant tumor, and elderly patients are likely to progress to a severe level; therefore, such patients should be monitored frequently.
<fig id="Fig2"><label>Fig. 2</label><caption><p>Flowchart for the management of acute cholangitis</p></caption><graphic position="anchor" xlink:href="534_2006_Article_1153_Fig2" id="MO2"></graphic></fig></p><sec id="Sec8"><title>Mild (grade I) acute cholangitis</title><p>Medical treatment may be sufficient. Biliary drainage is not required in most cases. However, for nonresponders to medical treatment, the necessity of biliary drainage should be considered. Treatment options such as endoscopic, percutaneous, or operative intervention may be required, depending on the etiology. Some patients, such as those who develop postoperative cholangitis, may only require antibiotics and generally do not require intervention.</p></sec><sec id="Sec9"><title>Moderate (grade II) acute cholangitis</title><p>Patients with acute cholangitis who do not respond to medical treatment have moderate (grade II) acute cholangitis. In these patients, early endoscopic or percutaneous drainage or even emergent operative drainage with a T-tube should be performed. A definitive procedure should be performed to remove the cause of the obstruction once the patient is in a stable condition.</p></sec><sec id="Sec10"><title>Severe (grade III) acute cholangitis</title><p>Patients with acute cholangitis and organ failure are classified as having severe (grade <bold>III</bold>) acute cholangitis. These patients require organ support, such as ventilatory/circulatory management (e.g., endotracheal intubation, artificial respiration management, and the use of vasopressin), and treatment for disseminated intravascular coagulation (DIC) in addition to the general medical management. Urgent biliary drainage must be anticipated. When the patient is stabilized, urgent (ASAP) endoscopic or percutaneous transhepatic biliary drainage or an emergent operation with decompression of the bile duct with a T-tube should be performed. Definitive treatment of the cause of the obstruction, including endoscopic, percutaneous, or operative intervention, should be considered once the acute illness has resolved.</p></sec><sec id="Sec11"><title>Results of the Tokyo International Consensus Meeting</title><p>At the International Consensus Meeting, responses to the flowcharts for the management of the different grades of acute cholangitis were elicited and a consensus was reached (Fig. <xref rid="Fig3" ref-type="fig">3</xref>).
<fig id="Fig3"><label>Fig. 3</label><caption><p><bold>A</bold> Responses to the question “Do you agree with the flowchart for the management of mild acute (grade I) cholangitis?” The flowchart for the management of mild acute (grade I) cholangitis was agreed upon by 100% and 97% of the panelists and the audience, respectively. <bold>B</bold> Responses to the question “Do you agree with the flowchart for the management of moderate acute (grade II) cholangitis?” The flowchart for the management of moderate acute (grade II) cholangitis was agreed upon by 93% and 97% of the panelists and the audience, respectively. <bold>C</bold> Responses to the question “Do you agree with the flowchart for the management of severe acute (grade III) cholangitis?” The flowchart for the management of severe acute (grade III) cholangitis was agreed upon by 98% and 99% of the panelists and the audience, respectively</p></caption><graphic position="anchor" xlink:href="534_2006_Article_1153_Fig3" id="MO3"></graphic></fig></p></sec></sec><sec id="Sec12"><title>Flowchart for the management of acute cholecystitis</title><p>A flowchart for the management of acute cholecystitis is shown in Fig. <xref rid="Fig4" ref-type="fig">4</xref>. Early cholecystectomy is recommended for most patients, with laparoscopic cholecystectomy as the preferred method. Among high-risk patients, percutaneous gallbladder drainage is an alternative therapy for those patients who cannot safely undergo urgent/early cholecystectomy (level 4).<xref ref-type="bibr" rid="CR17">17</xref>,<xref ref-type="bibr" rid="CR18">18</xref><fig id="Fig4"><label>Fig. 4</label><caption><p>Flowchart for the management of acute cholecystitis. <italic>GB</italic>, gallbladder; <italic>LC</italic>, laparoscopic cholecystectomy</p></caption><graphic position="anchor" xlink:href="534_2006_Article_1153_Fig4" id="MO4"></graphic></fig></p><p>When a diagnosis of acute cholecystitis is suspected, medical treatment, including NPO, intravenous fluids, antibiotics, and analgesia, together with close monitoring of blood pressure, pulse, and urinary output should be initiated. Simultaneously, the grade of severity needs to be established. Appropriate treatment should be performed in accordance with the severity grade. The assessment of operative risk should also be evaluated based on the severity grade.</p><p>After the acute inflammation has been resolved by medical treatment and gallbladder drainage, it is desirable to perform a cholecystectomy to prevent recurrence. In surgically high-risk patients with cholecystolithasis, medical support after percutaneous cholecystolithotomy should be considered (level 4).<xref ref-type="bibr" rid="CR19">19</xref>–<xref ref-type="bibr" rid="CR21">21</xref> For patients with acalculous cholecystitis, cholecystectomy is not required, because recurrence of acute acalculous cholecystitis after gallbladder drainage is rare (level 4).<xref ref-type="bibr" rid="CR17">17</xref>,<xref ref-type="bibr" rid="CR22">22</xref></p><sec id="Sec13"><title>Mild (grade I) acute cholecystitis</title><p>Early laparoscopic cholecystectomy is the preferred treatment. Elective cholecystectomy may be selected (if early cholecystectomy is not performed) in order to improve other medical problems.</p></sec><sec id="Sec14"><title>Moderate (grade II) acute cholecystitis</title><p>Early laparoscopic or open cholecystectomy is preferred. If a patient has serious local inflammation making early cholecystectomy difficult, then percutaneous or operative drainage of the gallbladder is recommended. Elective cholecystectomy can be performed after improvement of the acute inflammatory process.</p></sec><sec id="Sec15"><title>Severe (grade III) acute cholecystitis</title><p>Severe (grade III) acute cholecystitis is accompanied by organ dysfunction and/or severe local inflammation. Appropriate organ support in addition to medical treatment is necessary for patients with organ dysfunction. Management of severe local inflammation by percutaneous gallbladder drainage and/or cholecystectomy is needed. Biliary peritonitis due to perforation of the gallbladder is an indication for urgent cholecystectomy and drainage. Elective cholecystectomy may be performed after improvement of the acute illness by gallbladder drainage.</p></sec><sec id="Sec16"><title>Results of the Tokyo International Consensus Meeting</title><p>At the International Consensus Meeting, flowcharts for the management of mild (grade <bold>I</bold>) and severe (grade <bold>III</bold>) acute cholecystitis were agreed upon by almost all of the participants; however, the flowchart for moderate (grade <bold>II</bold>) acute cholecystitis was agreed upon by fewer than 90% of the participants (Fig. <xref rid="Fig5" ref-type="fig">5</xref>).
<fig id="Fig5"><label>Fig. 5</label><caption><p><bold>A</bold> Responses to the question “Do you agree with the flowchart for the management of mild acute (grade I) cholecystitis?” The flowchart for the management of mild acute (grade I) cholecystitis was agreed upon by 92% and 87% of the panelists and the audience, respectively. <bold>B</bold> Responses to the question “Do you agree with the flowchart for the management of moderate acute (grade II) cholecystitis?” The flowchart for the management of moderate acute (grade II) cholecystitis was agreed upon by 89% and 83% of the Japanese panelists and the Japanese audience, respectively. C Responses to the question “Do you agree with the flowchart for the management of severe acute (grade III) cholecystitis?” The flowchart for the management of severe acute (grade III) cholecystitis was agreed upon by 97% and 95% of the panelists and audience, respectively</p></caption><graphic position="anchor" xlink:href="534_2006_Article_1153_Fig5" id="MO5"></graphic></fig></p></sec></sec></body><back><ack><title>Acknowledgment</title><p>We would like to express our deep gratitude to the Japanese Society for Abdominal Emergency Medicine, the Japan Biliary Association, and the Japanese Society of Hepato-Biliary-Pancreatic Surgery, who provided us with great support and guidance in the preparation of the Guidelines. 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