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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Disruption of the <italic>langerin</italic>/<italic>CD207</italic> Gene Abolishes Birbeck Granules without a Marked Loss of Langerhans Cell Function</title><author><name sortKey="Kissenpfennig, Adrien" sort="Kissenpfennig, Adrien" uniqKey="Kissenpfennig A" first="Adrien" last="Kissenpfennig">Adrien Kissenpfennig</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ait Yahia, Smina" sort="Ait Yahia, Smina" uniqKey="Ait Yahia S" first="Smina" last="Aït-Yahia">Smina Aït-Yahia</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Clair Moninot, Valerie" sort="Clair Moninot, Valerie" uniqKey="Clair Moninot V" first="Valérie" last="Clair-Moninot">Valérie Clair-Moninot</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Stossel, Hella" sort="Stossel, Hella" uniqKey="Stossel H" first="Hella" last="Stössel">Hella Stössel</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Badell, Edgar" sort="Badell, Edgar" uniqKey="Badell E" first="Edgar" last="Badell">Edgar Badell</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bordat, Yann" sort="Bordat, Yann" uniqKey="Bordat Y" first="Yann" last="Bordat">Yann Bordat</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Pooley, Joanne L" sort="Pooley, Joanne L" uniqKey="Pooley J" first="Joanne L." last="Pooley">Joanne L. Pooley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lang, Thierry" sort="Lang, Thierry" uniqKey="Lang T" first="Thierry" last="Lang">Thierry Lang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Prina, Eric" sort="Prina, Eric" uniqKey="Prina E" first="Eric" last="Prina">Eric Prina</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Coste, Isabelle" sort="Coste, Isabelle" uniqKey="Coste I" first="Isabelle" last="Coste">Isabelle Coste</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gresser, Olivia" sort="Gresser, Olivia" uniqKey="Gresser O" first="Olivia" last="Gresser">Olivia Gresser</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Renno, Toufic" sort="Renno, Toufic" uniqKey="Renno T" first="Toufic" last="Renno">Toufic Renno</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Winter, Nathalie" sort="Winter, Nathalie" uniqKey="Winter N" first="Nathalie" last="Winter">Nathalie Winter</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Milon, Genevieve" sort="Milon, Genevieve" uniqKey="Milon G" first="Geneviève" last="Milon">Geneviève Milon</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Shortman, Ken" sort="Shortman, Ken" uniqKey="Shortman K" first="Ken" last="Shortman">Ken Shortman</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Romani, Nikolaus" sort="Romani, Nikolaus" uniqKey="Romani N" first="Nikolaus" last="Romani">Nikolaus Romani</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lebecque, Serge" sort="Lebecque, Serge" uniqKey="Lebecque S" first="Serge" last="Lebecque">Serge Lebecque</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Malissen, Bernard" sort="Malissen, Bernard" uniqKey="Malissen B" first="Bernard" last="Malissen">Bernard Malissen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Saeland, Sem" sort="Saeland, Sem" uniqKey="Saeland S" first="Sem" last="Saeland">Sem Saeland</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Douillard, Patrice" sort="Douillard, Patrice" uniqKey="Douillard P" first="Patrice" last="Douillard">Patrice Douillard</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15601833</idno><idno type="pmc">538791</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC538791</idno><idno type="RBID">PMC:538791</idno><idno type="doi">10.1128/MCB.25.1.88-99.2005</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">001031</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001031</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Disruption of the <italic>langerin</italic>/<italic>CD207</italic> Gene Abolishes Birbeck Granules without a Marked Loss of Langerhans Cell Function</title><author><name sortKey="Kissenpfennig, Adrien" sort="Kissenpfennig, Adrien" uniqKey="Kissenpfennig A" first="Adrien" last="Kissenpfennig">Adrien Kissenpfennig</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ait Yahia, Smina" sort="Ait Yahia, Smina" uniqKey="Ait Yahia S" first="Smina" last="Aït-Yahia">Smina Aït-Yahia</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Clair Moninot, Valerie" sort="Clair Moninot, Valerie" uniqKey="Clair Moninot V" first="Valérie" last="Clair-Moninot">Valérie Clair-Moninot</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Stossel, Hella" sort="Stossel, Hella" uniqKey="Stossel H" first="Hella" last="Stössel">Hella Stössel</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Badell, Edgar" sort="Badell, Edgar" uniqKey="Badell E" first="Edgar" last="Badell">Edgar Badell</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bordat, Yann" sort="Bordat, Yann" uniqKey="Bordat Y" first="Yann" last="Bordat">Yann Bordat</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Pooley, Joanne L" sort="Pooley, Joanne L" uniqKey="Pooley J" first="Joanne L." last="Pooley">Joanne L. Pooley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lang, Thierry" sort="Lang, Thierry" uniqKey="Lang T" first="Thierry" last="Lang">Thierry Lang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Prina, Eric" sort="Prina, Eric" uniqKey="Prina E" first="Eric" last="Prina">Eric Prina</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Coste, Isabelle" sort="Coste, Isabelle" uniqKey="Coste I" first="Isabelle" last="Coste">Isabelle Coste</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gresser, Olivia" sort="Gresser, Olivia" uniqKey="Gresser O" first="Olivia" last="Gresser">Olivia Gresser</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Renno, Toufic" sort="Renno, Toufic" uniqKey="Renno T" first="Toufic" last="Renno">Toufic Renno</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Winter, Nathalie" sort="Winter, Nathalie" uniqKey="Winter N" first="Nathalie" last="Winter">Nathalie Winter</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Milon, Genevieve" sort="Milon, Genevieve" uniqKey="Milon G" first="Geneviève" last="Milon">Geneviève Milon</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Shortman, Ken" sort="Shortman, Ken" uniqKey="Shortman K" first="Ken" last="Shortman">Ken Shortman</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Romani, Nikolaus" sort="Romani, Nikolaus" uniqKey="Romani N" first="Nikolaus" last="Romani">Nikolaus Romani</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lebecque, Serge" sort="Lebecque, Serge" uniqKey="Lebecque S" first="Serge" last="Lebecque">Serge Lebecque</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Malissen, Bernard" sort="Malissen, Bernard" uniqKey="Malissen B" first="Bernard" last="Malissen">Bernard Malissen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Saeland, Sem" sort="Saeland, Sem" uniqKey="Saeland S" first="Sem" last="Saeland">Sem Saeland</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Douillard, Patrice" sort="Douillard, Patrice" uniqKey="Douillard P" first="Patrice" last="Douillard">Patrice Douillard</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Molecular and Cellular Biology</title><idno type="ISSN">0270-7306</idno><idno type="eISSN">1098-5549</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Langerin is a C-type lectin expressed by a subset of dendritic leukocytes, the Langerhans cells (LC). Langerin is a cell surface receptor that induces the formation of an LC-specific organelle, the Birbeck granule (BG). We generated a <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> mouse on a C57BL/6 background which did not display any macroscopic aberrant development. In the absence of langerin, LC were detected in normal numbers in the epidermis but the cells lacked BG. LC of <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> mice did not present other phenotypic alterations compared to wild-type littermates. Functionally, the <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> LC were able to capture antigen, to migrate towards skin draining lymph nodes, and to undergo phenotypic maturation. In addition, <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> mice were not impaired in their capacity to process native OVA protein for <italic>I</italic>-<italic>A</italic><sup><italic>b</italic></sup>-restricted presentation to CD4<sup>+</sup> T lymphocytes or for <italic>H</italic>-<italic>2K</italic><sup><italic>b</italic></sup>-restricted cross-presentation to CD8<sup>+</sup> T lymphocytes. <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> mice inoculated with mannosylated or skin-tropic microorganisms did not display an altered pathogen susceptibility. Finally, chemical mutagenesis resulted in a similar rate of skin tumor development in <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> and wild-type mice. Overall, our data indicate that langerin and BG are dispensable for a number of LC functions. The <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> C57BL/6 mouse should be a valuable model for further functional exploration of langerin and the role of BG.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Mol Cell Biol</journal-id><journal-id journal-id-type="publisher-id">mcb</journal-id><journal-title>Molecular and Cellular Biology</journal-title><issn pub-type="ppub">0270-7306</issn><issn pub-type="epub">1098-5549</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15601833</article-id><article-id pub-id-type="pmc">538791</article-id><article-id pub-id-type="publisher-id">1428-04</article-id><article-id pub-id-type="doi">10.1128/MCB.25.1.88-99.2005</article-id><article-categories><subj-group subj-group-type="heading"><subject>Mammalian Genetic Models with Minimal or Complex Phenotypes</subject></subj-group></article-categories><title-group><article-title>Disruption of the <italic>langerin</italic>/<italic>CD207</italic> Gene Abolishes Birbeck Granules without a Marked Loss of Langerhans Cell Function</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kissenpfennig</surname><given-names>Adrien</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Aït-Yahia</surname><given-names>Smina</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Clair-Moninot</surname><given-names>Valérie</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Stössel</surname><given-names>Hella</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Badell</surname><given-names>Edgar</given-names></name><xref ref-type="aff" rid="aff1">4</xref></contrib><contrib contrib-type="author"><name><surname>Bordat</surname><given-names>Yann</given-names></name><xref ref-type="aff" rid="aff1">4</xref></contrib><contrib contrib-type="author"><name><surname>Pooley</surname><given-names>Joanne L.</given-names></name><xref ref-type="aff" rid="aff1">5</xref></contrib><contrib contrib-type="author"><name><surname>Lang</surname><given-names>Thierry</given-names></name><xref ref-type="aff" rid="aff1">6</xref></contrib><contrib contrib-type="author"><name><surname>Prina</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="aff1">6</xref></contrib><contrib contrib-type="author"><name><surname>Coste</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Gresser</surname><given-names>Olivia</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Renno</surname><given-names>Toufic</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Winter</surname><given-names>Nathalie</given-names></name><xref ref-type="aff" rid="aff1">4</xref></contrib><contrib contrib-type="author"><name><surname>Milon</surname><given-names>Geneviève</given-names></name><xref ref-type="aff" rid="aff1">6</xref></contrib><contrib contrib-type="author"><name><surname>Shortman</surname><given-names>Ken</given-names></name><xref ref-type="aff" rid="aff1">5</xref></contrib><contrib contrib-type="author"><name><surname>Romani</surname><given-names>Nikolaus</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Lebecque</surname><given-names>Serge</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Malissen</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Saeland</surname><given-names>Sem</given-names></name><xref ref-type="aff" rid="aff1">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Douillard</surname><given-names>Patrice</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib></contrib-group><aff id="aff1">Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS-Université de la Méditerranée, Parc Scientifique de Luminy, Marseille,<label>1</label> Laboratory for Immunological Research, Schering Plough, Dardilly,<label>2</label> Unité d'Immunophysiologie et Parasitisme Intracellulaire,<label>6</label> Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France,<label>4</label> Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria,<label>3</label> The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia<label>5</label></aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address for Sem Saeland: Schering Plough, Laboratory for Immunological Research, 27, Chemin des Peupliers, BP 11, 69571 Dardilly cedex, France. Phone: 33 4 72 17 27 00. Fax: 33 4 78 35 47 50. E-mail: <email>semsaeland@yahoo.fr</email>. Mailing address for Bernard Malissen: Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS-Université de la Méditerranée, Parc Scientifique de Luminy, 13288 Marseille Cedex 9, France. Phone: 33 491 26 94 78. Fax: 33 491 26 94 30. E-mail: <email>bernardm@ciml.univ-mrs.fr</email>.</p></fn></author-notes><pub-date pub-type="ppub"><month>1</month><year>2005</year></pub-date><volume>25</volume><issue>1</issue><fpage>88</fpage><lpage>99</lpage><history><date date-type="received"><day>2</day><month>8</month><year>2004</year></date><date date-type="rev-recd"><day>3</day><month>9</month><year>2004</year></date><date date-type="accepted"><day>10</day><month>10</month><year>2004</year></date></history><copyright-statement>Copyright © 2005, American Society for Microbiology</copyright-statement><copyright-year>2005</copyright-year><abstract><p>Langerin is a C-type lectin expressed by a subset of dendritic leukocytes, the Langerhans cells (LC). Langerin is a cell surface receptor that induces the formation of an LC-specific organelle, the Birbeck granule (BG). We generated a <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> mouse on a C57BL/6 background which did not display any macroscopic aberrant development. In the absence of langerin, LC were detected in normal numbers in the epidermis but the cells lacked BG. LC of <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> mice did not present other phenotypic alterations compared to wild-type littermates. Functionally, the <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> LC were able to capture antigen, to migrate towards skin draining lymph nodes, and to undergo phenotypic maturation. In addition, <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> mice were not impaired in their capacity to process native OVA protein for <italic>I</italic>-<italic>A</italic><sup><italic>b</italic></sup>-restricted presentation to CD4<sup>+</sup> T lymphocytes or for <italic>H</italic>-<italic>2K</italic><sup><italic>b</italic></sup>-restricted cross-presentation to CD8<sup>+</sup> T lymphocytes. <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> mice inoculated with mannosylated or skin-tropic microorganisms did not display an altered pathogen susceptibility. Finally, chemical mutagenesis resulted in a similar rate of skin tumor development in <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> and wild-type mice. Overall, our data indicate that langerin and BG are dispensable for a number of LC functions. The <italic>langerin</italic><sup>−</sup><sup>/</sup><sup>−</sup> C57BL/6 mouse should be a valuable model for further functional exploration of langerin and the role of BG.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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