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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rapid Microtubule-dependent Induction of Neurite-like Extensions in NIH 3T3 Fibroblasts by Inhibition of ROCK and Cbl</title><author><name sortKey="Scaife, Robin M" sort="Scaife, Robin M" uniqKey="Scaife R" first="Robin M." last="Scaife">Robin M. Scaife</name><affiliation><nlm:aff id="aff1"> Department of Pathology, University of Western Australia, Crawley, WA 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff2"> Départment de Réponse et Dynamique Cellulaires, Commissariat à l'Energie Atomique, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Job, Didier" sort="Job, Didier" uniqKey="Job D" first="Didier" last="Job">Didier Job</name><affiliation><nlm:aff id="aff2"> Départment de Réponse et Dynamique Cellulaires, Commissariat à l'Energie Atomique, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Langdon, Wallace Y" sort="Langdon, Wallace Y" uniqKey="Langdon W" first="Wallace Y." last="Langdon">Wallace Y. Langdon</name><affiliation><nlm:aff id="aff1"> Department of Pathology, University of Western Australia, Crawley, WA 6009, Australia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">12960437</idno><idno type="pmc">266776</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC266776</idno><idno type="RBID">PMC:266776</idno><idno type="doi">10.1091/mbc.E02-11-0739</idno><date when="2003">2003</date><idno type="wicri:Area/Pmc/Corpus">001029</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001029</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Rapid Microtubule-dependent Induction of Neurite-like Extensions in NIH 3T3 Fibroblasts by Inhibition of ROCK and Cbl</title><author><name sortKey="Scaife, Robin M" sort="Scaife, Robin M" uniqKey="Scaife R" first="Robin M." last="Scaife">Robin M. Scaife</name><affiliation><nlm:aff id="aff1"> Department of Pathology, University of Western Australia, Crawley, WA 6009, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff2"> Départment de Réponse et Dynamique Cellulaires, Commissariat à l'Energie Atomique, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Job, Didier" sort="Job, Didier" uniqKey="Job D" first="Didier" last="Job">Didier Job</name><affiliation><nlm:aff id="aff2"> Départment de Réponse et Dynamique Cellulaires, Commissariat à l'Energie Atomique, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Langdon, Wallace Y" sort="Langdon, Wallace Y" uniqKey="Langdon W" first="Wallace Y." last="Langdon">Wallace Y. Langdon</name><affiliation><nlm:aff id="aff1"> Department of Pathology, University of Western Australia, Crawley, WA 6009, Australia</nlm:aff></affiliation></author></analytic><series><title level="j">Molecular Biology of the Cell</title><idno type="ISSN">1059-1524</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A number of key cellular functions, such as morphological differentiation and cell motility, are closely associated with changes in cytoskeletal dynamics. Many of the principal signaling components involved in actin cytoskeletal dynamics have been identified, and these have been shown to be critically involved in cell motility. In contrast, signaling to microtubules remains relatively uncharacterized, and the importance of signaling pathways in modulation of microtubule dynamics has so far not been established clearly. We report here that the Rho-effector ROCK and the multiadaptor proto-oncoprotein Cbl can profoundly affect the microtubule cytoskeleton. Simultaneous inhibition of these two signaling molecules induces a dramatic rearrangement of the microtubule cytoskeleton into microtubule bundles. The formation of these microtubule bundles, which does not involve signaling by Rac, Cdc42, Crk, phosphatidylinositol 3-kinase, and Abl, is sufficient to induce distinct neurite-like extensions in NIH 3T3 fibroblasts, even in the absence of microfilaments. This novel microtubule-dependent function that promotes neurite-like extensions is not dependent on net changes in microtubule polymerization or stabilization, but rather involves selective elongation and reorganization of microtubules into long bundles.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Mol Biol Cell</journal-id><journal-id journal-id-type="publisher-id">molbiolcell</journal-id><journal-title>Molecular Biology of the Cell</journal-title><issn pub-type="ppub">1059-1524</issn><publisher><publisher-name>The American Society for Cell Biology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">12960437</article-id><article-id pub-id-type="pmc">266776</article-id><article-id pub-id-type="publisher-id">0144605</article-id><article-id pub-id-type="doi">10.1091/mbc.E02-11-0739</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Rapid Microtubule-dependent Induction of Neurite-like Extensions in NIH 3T3 Fibroblasts by Inhibition of ROCK and Cbl</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Scaife</surname><given-names>Robin M.</given-names></name><xref ref-type="aff" rid="aff1">*</xref><xref ref-type="aff" rid="aff2">†</xref><xref ref-type="corresp" rid="cor1">‡</xref></contrib><contrib contrib-type="author"><name><surname>Job</surname><given-names>Didier</given-names></name><xref ref-type="aff" rid="aff2">†</xref></contrib><contrib contrib-type="author"><name><surname>Langdon</surname><given-names>Wallace Y.</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib></contrib-group><aff id="aff1"><label>*</label> Department of Pathology, University of Western Australia, Crawley, WA 6009, Australia</aff><aff id="aff2"><label>†</label> Départment de Réponse et Dynamique Cellulaires, Commissariat à l'Energie Atomique, Grenoble, France</aff><contrib-group><contrib contrib-type="editor"><name><surname>Salmon</surname><given-names>Ted</given-names></name><role>Monitoring Editor</role></contrib></contrib-group><author-notes><fn id="cor1"><label>‡</label><p> Corresponding author. E-mail address: <email>rscaife@cyllene.uwa.edu.au</email>. </p></fn></author-notes><pub-date pub-type="ppub"><month>11</month><year>2003</year></pub-date><volume>14</volume><issue>11</issue><fpage>4605</fpage><lpage>4617</lpage><history><date date-type="received"><day>18</day><month>11</month><year>2002</year></date><date date-type="rev-recd"><day>26</day><month>6</month><year>2003</year></date><date date-type="accepted"><day>14</day><month>7</month><year>2003</year></date></history><copyright-statement>Copyright © 2003, The American Society for Cell Biology</copyright-statement><copyright-year>2003</copyright-year><abstract><p>A number of key cellular functions, such as morphological differentiation and cell motility, are closely associated with changes in cytoskeletal dynamics. Many of the principal signaling components involved in actin cytoskeletal dynamics have been identified, and these have been shown to be critically involved in cell motility. In contrast, signaling to microtubules remains relatively uncharacterized, and the importance of signaling pathways in modulation of microtubule dynamics has so far not been established clearly. We report here that the Rho-effector ROCK and the multiadaptor proto-oncoprotein Cbl can profoundly affect the microtubule cytoskeleton. Simultaneous inhibition of these two signaling molecules induces a dramatic rearrangement of the microtubule cytoskeleton into microtubule bundles. The formation of these microtubule bundles, which does not involve signaling by Rac, Cdc42, Crk, phosphatidylinositol 3-kinase, and Abl, is sufficient to induce distinct neurite-like extensions in NIH 3T3 fibroblasts, even in the absence of microfilaments. This novel microtubule-dependent function that promotes neurite-like extensions is not dependent on net changes in microtubule polymerization or stabilization, but rather involves selective elongation and reorganization of microtubules into long bundles.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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