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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ecological Genomics of Marine Picocyanobacteria<xref ref-type="fn" rid="fn1">†</xref>
</title>
<author><name sortKey="Scanlan, D J" sort="Scanlan, D J" uniqKey="Scanlan D" first="D. J." last="Scanlan">D. J. Scanlan</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ostrowski, M" sort="Ostrowski, M" uniqKey="Ostrowski M" first="M." last="Ostrowski">M. Ostrowski</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mazard, S" sort="Mazard, S" uniqKey="Mazard S" first="S." last="Mazard">S. Mazard</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dufresne, A" sort="Dufresne, A" uniqKey="Dufresne A" first="A." last="Dufresne">A. Dufresne</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garczarek, L" sort="Garczarek, L" uniqKey="Garczarek L" first="L." last="Garczarek">L. Garczarek</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hess, W R" sort="Hess, W R" uniqKey="Hess W" first="W. R." last="Hess">W. R. Hess</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Post, A F" sort="Post, A F" uniqKey="Post A" first="A. F." last="Post">A. F. Post</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hagemann, M" sort="Hagemann, M" uniqKey="Hagemann M" first="M." last="Hagemann">M. Hagemann</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Paulsen, I" sort="Paulsen, I" uniqKey="Paulsen I" first="I." last="Paulsen">I. Paulsen</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Partensky, F" sort="Partensky, F" uniqKey="Partensky F" first="F." last="Partensky">F. Partensky</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
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<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19487728</idno>
<idno type="pmc">2698417</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698417</idno>
<idno type="RBID">PMC:2698417</idno>
<idno type="doi">10.1128/MMBR.00035-08</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">001027</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001027</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ecological Genomics of Marine Picocyanobacteria<xref ref-type="fn" rid="fn1">†</xref>
</title>
<author><name sortKey="Scanlan, D J" sort="Scanlan, D J" uniqKey="Scanlan D" first="D. J." last="Scanlan">D. J. Scanlan</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ostrowski, M" sort="Ostrowski, M" uniqKey="Ostrowski M" first="M." last="Ostrowski">M. Ostrowski</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mazard, S" sort="Mazard, S" uniqKey="Mazard S" first="S." last="Mazard">S. Mazard</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dufresne, A" sort="Dufresne, A" uniqKey="Dufresne A" first="A." last="Dufresne">A. Dufresne</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garczarek, L" sort="Garczarek, L" uniqKey="Garczarek L" first="L." last="Garczarek">L. Garczarek</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hess, W R" sort="Hess, W R" uniqKey="Hess W" first="W. R." last="Hess">W. R. Hess</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Post, A F" sort="Post, A F" uniqKey="Post A" first="A. F." last="Post">A. F. Post</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hagemann, M" sort="Hagemann, M" uniqKey="Hagemann M" first="M." last="Hagemann">M. Hagemann</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Paulsen, I" sort="Paulsen, I" uniqKey="Paulsen I" first="I." last="Paulsen">I. Paulsen</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Partensky, F" sort="Partensky, F" uniqKey="Partensky F" first="F." last="Partensky">F. Partensky</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Microbiology and Molecular Biology Reviews : MMBR</title>
<idno type="ISSN">1092-2172</idno>
<idno type="eISSN">1098-5557</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<front><div type="abstract" xml:lang="en"><p>Summary: Marine picocyanobacteria of the genera <italic>Prochlorococcus</italic>
and <italic>Synechococcus</italic>
numerically dominate the picophytoplankton of the world ocean, making a key contribution to global primary production. <italic>Prochlorococcus</italic>
was isolated around 20 years ago and is probably the most abundant photosynthetic organism on Earth. The genus comprises specific ecotypes which are phylogenetically distinct and differ markedly in their photophysiology, allowing growth over a broad range of light and nutrient conditions within the 45°N to 40°S latitudinal belt that they occupy. <italic>Synechococcus</italic>
and <italic>Prochlorococcus</italic>
are closely related, together forming a discrete picophytoplankton clade, but are distinguishable by their possession of dissimilar light-harvesting apparatuses and differences in cell size and elemental composition. <italic>Synechococcus</italic>
strains have a ubiquitous oceanic distribution compared to that of <italic>Prochlorococcus</italic>
strains and are characterized by phylogenetically discrete lineages with a wide range of pigmentation. In this review, we put our current knowledge of marine picocyanobacterial genomics into an environmental context and present previously unpublished genomic information arising from extensive genomic comparisons in order to provide insights into the adaptations of these marine microbes to their environment and how they are reflected at the genomic level.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Microbiol Mol Biol Rev</journal-id>
<journal-id journal-id-type="publisher-id">mmbr</journal-id>
<journal-title>Microbiology and Molecular Biology Reviews : MMBR</journal-title>
<issn pub-type="ppub">1092-2172</issn>
<issn pub-type="epub">1098-5557</issn>
<publisher><publisher-name>American Society for Microbiology (ASM)</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19487728</article-id>
<article-id pub-id-type="pmc">2698417</article-id>
<article-id pub-id-type="publisher-id">0035-08</article-id>
<article-id pub-id-type="doi">10.1128/MMBR.00035-08</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Reviews</subject>
</subj-group>
</article-categories>
<title-group><article-title>Ecological Genomics of Marine Picocyanobacteria<xref ref-type="fn" rid="fn1">†</xref>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Scanlan</surname>
<given-names>D. J.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ostrowski</surname>
<given-names>M.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mazard</surname>
<given-names>S.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dufresne</surname>
<given-names>A.</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
<xref ref-type="aff" rid="aff1">3</xref>
<xref ref-type="aff" rid="aff1">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Garczarek</surname>
<given-names>L.</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
<xref ref-type="aff" rid="aff1">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hess</surname>
<given-names>W. R.</given-names>
</name>
<xref ref-type="aff" rid="aff1">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Post</surname>
<given-names>A. F.</given-names>
</name>
<xref ref-type="aff" rid="aff1">6</xref>
<xref ref-type="aff" rid="aff1">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hagemann</surname>
<given-names>M.</given-names>
</name>
<xref ref-type="aff" rid="aff1">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Paulsen</surname>
<given-names>I.</given-names>
</name>
<xref ref-type="aff" rid="aff1">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Partensky</surname>
<given-names>F.</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
<xref ref-type="aff" rid="aff1">3</xref>
</contrib>
</contrib-group>
<aff id="aff1">Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom,<label>1</label>
UPMC-Université Paris 06, Station Biologique, BP 74, 29682 Roscoff Cedex, France,<label>2</label>
CNRS, UMR 7144, Groupe Plancton Océanique, BP 74, 29682 Roscoff Cedex, France,<label>3</label>
Université Rennes 1, UMR 6553 EcoBio, IFR90/FR2116, CAREN, 35042 Rennes, France,<label>4</label>
University Freiburg, Faculty of Biology, Schänzlestrasse 1, D-79104 Freiburg, Germany,<label>5</label>
H. Steinitz Marine Biology Laboratory, The Interuniversity Institute for Marine Science, POB 469, Eilat 88103, Israel,<label>6</label>
Marine Biological Laboratory, Woods Hole, Massachusetts,<label>7</label>
Universität Rostock, Inst. Biowissenschaften, Pflanzenphysiologie, Einsteinstr. 3, D-18051 Rostock, Germany,<label>8</label>
Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales, Australia<label>9</label>
</aff>
<author-notes><fn id="cor1"><label>*</label>
<p>Corresponding author. Mailing address: Dept. of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom. Phone: 44 24 76 528363. Fax: 44 24 76 523701. E-mail: <email>d.j.scanlan@warwick.ac.uk</email>
</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>6</month>
<year>2009</year>
</pub-date>
<volume>73</volume>
<issue>2</issue>
<fpage>249</fpage>
<lpage>299</lpage>
<permissions><copyright-statement>Copyright © 2009, American Society for Microbiology</copyright-statement>
</permissions>
<self-uri xlink:title="pdf" xlink:href="zmr00209000249.pdf"></self-uri>
<abstract><p>Summary: Marine picocyanobacteria of the genera <italic>Prochlorococcus</italic>
and <italic>Synechococcus</italic>
numerically dominate the picophytoplankton of the world ocean, making a key contribution to global primary production. <italic>Prochlorococcus</italic>
was isolated around 20 years ago and is probably the most abundant photosynthetic organism on Earth. The genus comprises specific ecotypes which are phylogenetically distinct and differ markedly in their photophysiology, allowing growth over a broad range of light and nutrient conditions within the 45°N to 40°S latitudinal belt that they occupy. <italic>Synechococcus</italic>
and <italic>Prochlorococcus</italic>
are closely related, together forming a discrete picophytoplankton clade, but are distinguishable by their possession of dissimilar light-harvesting apparatuses and differences in cell size and elemental composition. <italic>Synechococcus</italic>
strains have a ubiquitous oceanic distribution compared to that of <italic>Prochlorococcus</italic>
strains and are characterized by phylogenetically discrete lineages with a wide range of pigmentation. In this review, we put our current knowledge of marine picocyanobacterial genomics into an environmental context and present previously unpublished genomic information arising from extensive genomic comparisons in order to provide insights into the adaptations of these marine microbes to their environment and how they are reflected at the genomic level.</p>
</abstract>
</article-meta>
</front>
<floats-wrap><fig position="float" id="f1"><label>FIG. 1.</label>
<caption><p>Neighbor-joining tree, based on 16S rRNA gene sequences, indicating the phylogenetic relationships among marine picocyanobacteria that are the subject of this review. Bootstrap values of >70% are shown. Strains with sequenced genomes are in boldface.</p>
</caption>
<graphic xlink:href="zmr0020922160001"></graphic>
</fig>
<fig position="float" id="f2"><label>FIG. 2.</label>
<caption><p>Genome sizes of marine picocyanobacteria compared to a representative selection of other cyanobacteria.</p>
</caption>
<graphic xlink:href="zmr0020922160002"></graphic>
</fig>
<fig position="float" id="f3"><label>FIG. 3.</label>
<caption><p>Genome plot of recently acquired genomic islands in marine <italic>Synechococcus</italic>
and <italic>Prochlorococcus</italic>
strains. For each genome predicted islands are highlighted in gray, except for the phycobilisome gene cluster, which is highlighted in orange. The frequency with which an ortholog appears among the 14 genomes (11 <italic>Synechococcus</italic>
and three <italic>Prochlorococcus</italic>
) of the curated Cyanorak database (<ext-link ext-link-type="uri" xlink:href="http://www.sb-roscoff.fr/Phyto/cyanorak/">http://www.sb-roscoff.fr/Phyto/cyanorak/</ext-link>
) is represented by a black bar (a core gene is present in 14 genomes). Giant ORFs are highlighted in blue. Tetranucleotide frequency in overlapping 5,000 bp intervals was transformed by principal-component analysis, and the deviation in tetranucleotide frequency is plotted in the box below each genome as the first principal component (PC1). The positions of tRNA genes (purple bars) and mobility genes, such as those encoding phage integrases and transposases, are also indicated (green bars). While for marine <italic>Synechococcus</italic>
strains and <italic>Prochlorococcus</italic>
sp. strain MIT9313 the deviation in tetranucleotide frequency correlates well with genomic regions bounded by mobility genes and containing unique genes or orthologs common to few genomes, for the streamlined, rapidly evolving A+T-rich genomes of <italic>Prochlorococcus</italic>
there is a poor correlation between tetranucleotide frequency and predicted islands. (Modified from reference <xref ref-type="bibr" rid="r56">56</xref>
with permission of the publisher.)</p>
</caption>
<graphic xlink:href="zmr0020922160003"></graphic>
</fig>
<fig position="float" id="f4"><label>FIG. 4.</label>
<caption><p>Dot blot hybridization data showing the distribution of HLI, HLII, and LL <italic>Prochlorococcus</italic>
ecotypes and <italic>Synechococcus</italic>
clades II to IV in the euphotic zone along an Atlantic Meridional cruise track (AMT 15). Contour plots indicate the percent relative hybridization. For each panel the <italic>y</italic>
axis is the light intensity (percent surface irradiance) and the <italic>x</italic>
axis the latitude (degrees north or south of the equator). Black contour lines indicate the depth in meters, and black dots represent sampling points. (Adapted from reference <xref ref-type="bibr" rid="r340">340</xref>
with permission of Wiley-Blackwell.)</p>
</caption>
<graphic xlink:href="zmr0020922160004"></graphic>
</fig>
<fig position="float" id="f5"><label>FIG. 5.</label>
<caption><p><italic>Synechococcus</italic>
pigment types and associated phycobilisome structures. (A) Photograph of cultures representative of the three main pigment types (1 to 3) and subtypes (3a to 3c). Pigment type 3d corresponds to type IV chromatic adapters that modify their pigmentation from subtype 3b (in green light) to 3c (in blue light). (B) Models of the phycobilisome structures of the three main pigment types. (Adapted from reference <xref ref-type="bibr" rid="r263">263</xref>
with permission of the publisher.)</p>
</caption>
<graphic xlink:href="zmr0020922160005"></graphic>
</fig>
<fig position="float" id="f6"><label>FIG. 6.</label>
<caption><p>Neighbor-joining tree indicating the phylogenetic relatedness of the different peroxiredoxins found in marine picocyanobacteria. The Cyanorak cluster numbers are indicated for each peroxiredoxin type. Color coding: green, <italic>Prochlorococcus</italic>
; orange, marine <italic>Synechococcus</italic>
; blue, other cyanobacteria.</p>
</caption>
<graphic xlink:href="zmr0020922160006"></graphic>
</fig>
<fig position="float" id="f7"><label>FIG. 7.</label>
<caption><p>Phylogenetic analysis of P<sub>II</sub>
proteins in unicellular marine (<italic>Synechococcus</italic>
and <italic>Prochlorococcus</italic>
) and unicellular freshwater (<italic>Synechocystis</italic>
sp. strain PCC6803 and <italic>Synechococcus elongatus</italic>
PCC7942) cyanobacteria. The two P<sub>II</sub>
proteins of <italic>E. coli</italic>
were chosen as outgroups. Bootstrap values are given at nodes if at least 60. The two paralogs of <italic>Synechococcus</italic>
sp. strain WH5701 are indicated in boldface. Color coding: green, <italic>Prochlorococcus</italic>
; orange, marine <italic>Synechococcus</italic>
; blue, other cyanobacteria; black, <italic>E. coli</italic>
.</p>
</caption>
<graphic xlink:href="zmr0020922160007"></graphic>
</fig>
<fig position="float" id="f8"><label>FIG. 8.</label>
<caption><p>Multiple sequence alignment of cyanobacterial P<sub>II</sub>
of marine <italic>Synechococcus</italic>
strains (Syn), selected <italic>Prochlorococcus</italic>
strains (Pro), and the two freshwater strains <italic>Synechocystis</italic>
sp. strain PCC6803 and <italic>Synechococcus elongatus</italic>
PCC7942 and of the two <italic>E. coli</italic>
P<sub>II</sub>
proteins. Sites that belong to a previously suggested cyanobacterial signature (<xref ref-type="bibr" rid="r216">216</xref>
) are indicated by arrows. #, the functionally relevant residue Arg45, required for interaction with NAGK; $, Ser49, which becomes phosphorylated in <italic>S. elongatus</italic>
PCC 7942 (<xref ref-type="bibr" rid="r78">78</xref>
). Asterisks and numbers above the sequences mark every 10th position.</p>
</caption>
<graphic xlink:href="zmr0020922160008"></graphic>
</fig>
<fig position="float" id="f9"><label>FIG. 9.</label>
<caption><p>Partial alignment of a genomic fragment containing the gene clusters for assimilation pathways of major N sources for marine <italic>Synechococcus</italic>
strains organized according to phylogenetic clusters (<xref ref-type="bibr" rid="r56">56</xref>
), i.e., urea (blue), nitrate (green), nitrite (pink), and cyanate (yellow), in addition to N metabolism genes (purple), other nonrelated genes (white), and fully conserved genes flanking this region (red). Genes encoding the enzyme central to each pathway are in dark color, while genes involved in accessory functions (acquisition/cofactor biosynthesis) are in light color. Dotted lines and block arrows indicate mobile fragments of 10 to 25 genes in size that are subject to deletion/insertion events in different lineages. The upper panel presents the relevant genomic regions in <italic>Synechococcus</italic>
sp. strain WH5701.</p>
</caption>
<graphic xlink:href="zmr0020922160009"></graphic>
</fig>
<fig position="float" id="f10"><label>FIG. 10.</label>
<caption><p>Neighbor-joining tree based on the amino acid sequences of PstS and SphX from marine and freshwater cyanobacteria. Three families of phosphate-binding proteins are evident in marine <italic>Synechococcus</italic>
(PstSI, PstSII, and SphX), which suggests that these proteins are functionally distinct (e.g., they may display different affinities for the same substrate). The PstS sequences of HL and LL <italic>Prochlorococcus</italic>
strains, freshwater cyanobacteria, and marine <italic>Synechococcus</italic>
strains form separate clusters, while the SphX sequences all cluster together. The tree was constructed from an alignment using Clustal X v1.83. The bootstrap values were obtained through 1,000 repetitions. The tree was rooted on the PstS sequence of <italic>E. coli</italic>
K-12. Sequences were extracted from BLAST searches of GenBank (<ext-link ext-link-type="uri" xlink:href="www.ncbi.nlm.nih.gov/BLAST">www.ncbi.nlm.nih.gov/BLAST</ext-link>
) or using Cyanorak (<ext-link ext-link-type="uri" xlink:href="http://www.sb-roscoff.fr/Phyto/cyanorak/">http://www.sb-roscoff.fr/Phyto/cyanorak/</ext-link>
) or Cyanobase (<ext-link ext-link-type="uri" xlink:href="www.kazusa.or.jp/cyanobase/">www.kazusa.or.jp/cyanobase/</ext-link>
). The scale bar represents 10 substitutions per 100 nucleotides. Color coding: green, <italic>Prochlorococcus</italic>
; orange, marine <italic>Synechococcus</italic>
; blue, other cyanobacteria; black, cyanophage sequences.</p>
</caption>
<graphic xlink:href="zmr0020922160010"></graphic>
</fig>
<fig position="float" id="f11"><label>FIG. 11.</label>
<caption><p>Schematic representation of the different domain structures of phosphatases present in marine and freshwater cyanobacterial genomes. At least five different families of phosphatases are represented. Notable features include the variable domain structure of the large PhoA-type phosphatases which contain UshA and 5′ nucleotidase domains. SynWH7803_0111 includes an N-terminal insertion of a phytase-like domain (COG4222), homologous to SYNW0762, which is also represented in MED4_ 0708 and MIT9312_0720. COG3391 is a potential Zn-binding domain, which suggests a requirement for Zn as a cofactor. PhoX (<xref ref-type="bibr" rid="r332">332</xref>
) and PhoD (<xref ref-type="bibr" rid="r64">64</xref>
) homologs are also represented in a subset of strains. The approximate molecular mass is indicated by the scale at the bottom. Color coding of sequence names: green, <italic>Prochlorococcus</italic>
; orange, marine <italic>Synechococcus</italic>
; blue, other cyanobacteria; black, other bacteria. a, this ORF contains a potential frameshift; b, this ORF is truncated and hence is a probable pseudogene; c, this ORF spans only the N-terminal portion of PhoX; d, this ORF is truncated at its N terminus. (Adapted from reference <xref ref-type="bibr" rid="r192">192</xref>
with permission of the publisher.)</p>
</caption>
<graphic xlink:href="zmr0020922160011"></graphic>
</fig>
<fig position="float" id="f12"><label>FIG. 12.</label>
<caption><p>Multiple-sequence alignment, using ClustalX v1.83, of the N-terminal region of the PhoR histidine kinase in marine picocyanobacteria. Differences in the N-terminal sequences suggest alternative subcellular locations for PhoR in different strains of picocyanobacteria. Shown at the bottom is the probability of a transmembrane domain for the first 100 amino acids (aa) of the N-terminal regions (predicted by the TMHMM server) for the three groups of organisms defined in the text.</p>
</caption>
<graphic xlink:href="zmr0020922160012"></graphic>
</fig>
<fig position="float" id="f13"><label>FIG. 13.</label>
<caption><p>Phylogenetic relationships among CRP family regulators of marine picocyanobacteria. The identified CRP regulators form four distinct clusters, i.e., NtcA, cluster 2049, cluster 1390, and PtrA, with decreasing levels of conservation and a further diverse group mostly composed of cluster 2546. Color coding: green, <italic>Prochlorococcus</italic>
; orange, marine <italic>Synechococcus</italic>
.</p>
</caption>
<graphic xlink:href="zmr0020922160013"></graphic>
</fig>
<fig position="float" id="f14"><label>FIG. 14.</label>
<caption><p>Marine picocyanobacterial genomic regions centered on a potential Fe regulator of the CRP family (cluster 1390). The genomic region for <italic>Synechococcus</italic>
sp. strain CC9605 is essentially the same as for CC9902/BL107 except that <italic>petF</italic>
, encoding ferredoxin, is located downstream of ferritin and upstream of the hypothetical proteins. For <italic>Synechococcus</italic>
at least, these genes are located in a genomic island (WH7805-ISL3, BL107-ISL6, CC9605-ISL12, CC9902-ISL-11, RS9916 ISL4). <italic>futA</italic>
, ABC-type iron transporter, periplasmic iron-binding protein; <italic>futB</italic>
, ABC-type iron transporter, ATP-binding component; <italic>futC</italic>
, ABC-type iron transporter, membrane component; <italic>feoB</italic>
, ferrous iron uptake protein; <italic>isiB</italic>
, flavodoxin; <italic>som</italic>
, porin; <italic>trxB</italic>
, thioredoxin reductase; A, putative Fe-regulated hydroxylase; B, ABC molybdenum transporter-binding component; C, HupE hydrogenase component; chp, conserved hypothetical protein.</p>
</caption>
<graphic xlink:href="zmr0020922160014"></graphic>
</fig>
<fig position="float" id="f15"><label>FIG. 15.</label>
<caption><p>Phylogenetic relationships among marine picocyanobacterial sigma factors. A total of 136 sigma factors from 22 strains of marine picocyanobacteria (11 <italic>Synechococcus</italic>
[Syn] and 11 <italic>Prochlorococcus</italic>
[Pro] strains) were analyzed. The vegetative major sigma factor SigA and the four alternative type 2 sigma factors from <italic>Synechocystis</italic>
sp. strain PCC6803 were included for orientation. Clades A to E refer to different classes of closely related sigma factors from picocyanobacteria. Bootstrap numbers are given for major nodes. Color coding: green, <italic>Prochlorococcus</italic>
; orange, marine <italic>Synechococcus</italic>
; blue, other cyanobacteria. (See Fig. <xref rid="f16" ref-type="fig">16</xref>
for more information on clade D.)</p>
</caption>
<graphic xlink:href="zmr0020922160015"></graphic>
</fig>
<fig position="float" id="f16"><label>FIG. 16.</label>
<caption><p>Phylogenetic relationships among clade D (Fig. <xref rid="f15" ref-type="fig">15</xref>
) type 2 alternative sigma factors. All <italic>Synechococcus</italic>
factors are indicated in boldface. For easier identification, GenBank tags are given and the respective part indicating the strain is underlined. The genes encoding these proteins are probably rapidly evolving, since a series of independent duplications (black dots) in the progenitors of single strains or two strains, respectively, is suggested by similarity and phylogenetic analysis. The proteins BL107_06099 and SynCC9902_0139 differ only by a single conservative exchange (identity at DNA level, 87%). Bootstrap numbers are given for all nodes. Color coding: green, <italic>Prochlorococcus</italic>
; orange, marine <italic>Synechococcus</italic>
.</p>
</caption>
<graphic xlink:href="zmr0020922160016"></graphic>
</fig>
<fig position="float" id="f17"><label>FIG. 17.</label>
<caption><p>DNA integration into the tmRNA gene of <italic>Synechococcus</italic>
sp. strain WH8102. The start of genomic island 1 is indicated, and the positions of three phage integrase genes are given by the blue boxes, together with their sequence ID. The order of <italic>ssrA</italic>
acceptor (tRNA-like) and coding (mRNA-like) segments is reversed in picocyanobacteria compared to most other bacteria (<xref ref-type="bibr" rid="r94">94</xref>
). The genetic element Synw12X (<xref ref-type="bibr" rid="r325">325</xref>
) is integrated into the 3′ end of <italic>ssrA</italic>
, far from the tRNA-like segment. Within the triplicated 33-bp <italic>attB</italic>
sequences resides an inverted repeat able to fold into a secondary structure (arrows). These elements exhibit compensatory base pair changes, indicating the functional importance of the stem-loop formed by this repeat.</p>
</caption>
<graphic xlink:href="zmr0020922160017"></graphic>
</fig>
<fig position="float" id="f18"><label>FIG. 18.</label>
<caption><p>Predicted secondary structures of the six selected ncRNAs from <italic>Synechococcus</italic>
sp. strain CC9311 belonging to the Yfr2 to -5 class. A characteristic motif is the conserved sequence 5′-GAAAC(U/A)AGG(C/U/A)AA-3′ in the single-stranded loop region labeled by the doughnut. This motif is similarly conserved between all members of this ncRNA class throughout the cyanobacterial radiation. The structures were drawn with mfold (<xref ref-type="bibr" rid="r339">339</xref>
).</p>
</caption>
<graphic xlink:href="zmr0020922160018"></graphic>
</fig>
<table-wrap position="float" id="t1"><label>TABLE 1.</label>
<caption><p>Summary of the different <italic>Prochlorococcus</italic>
and <italic>Synechococcus</italic>
genomes sequenced to date</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="1" align="center" valign="bottom">Genus and strain</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">RCC no.<xref ref-type="table-fn" rid="t1fn1"><italic>a</italic>
</xref>
</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Subcluster or ecotype<xref ref-type="table-fn" rid="t1fn2"><italic>b</italic>
</xref>
</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Clade no.<xref ref-type="table-fn" rid="t1fn3"><italic>c</italic>
</xref>
</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Genome size (Mb)</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">No. of protein-coding genes</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">GC (%)</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Status and accession no.<xref ref-type="table-fn" rid="t1fn4"><italic>d</italic>
</xref>
</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Reference</th>
</tr>
</thead>
<tbody><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9311</td>
<td colspan="1" rowspan="1" align="center" valign="top">1086</td>
<td colspan="1" rowspan="1" align="center" valign="top">5.1B</td>
<td colspan="1" rowspan="1" align="left" valign="top">I</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2.61</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2,892</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">52</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CP000435</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r214">214</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9605</td>
<td colspan="1" rowspan="1" align="center" valign="top">753</td>
<td colspan="1" rowspan="1" align="center" valign="top">5.1A</td>
<td colspan="1" rowspan="1" align="left" valign="top">II</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2.51</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2,645</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">59</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CP000110</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r56">56</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH8102</td>
<td colspan="1" rowspan="1" align="center" valign="top">539</td>
<td colspan="1" rowspan="1" align="center" valign="top">5.1A</td>
<td colspan="1" rowspan="1" align="left" valign="top">III</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2.43</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2,519</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">59</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:BX548020</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r212">212</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9902</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">5.1A</td>
<td colspan="1" rowspan="1" align="left" valign="top">IV</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2.23</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2,358</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">54</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CP000097</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r56">56</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> BL107</td>
<td colspan="1" rowspan="1" align="center" valign="top">515</td>
<td colspan="1" rowspan="1" align="center" valign="top">5.1A</td>
<td colspan="1" rowspan="1" align="left" valign="top">IV</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2.28</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2,553</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">54</td>
<td colspan="1" rowspan="1" align="left" valign="top">[WGS]:AATZ00000000</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r56">56</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7803</td>
<td colspan="1" rowspan="1" align="center" valign="top">752</td>
<td colspan="1" rowspan="1" align="center" valign="top">5.1B</td>
<td colspan="1" rowspan="1" align="left" valign="top">V</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2.37</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2,586</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">60</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CT971583</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r56">56</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7805</td>
<td colspan="1" rowspan="1" align="center" valign="top">1085</td>
<td colspan="1" rowspan="1" align="center" valign="top">5.1B</td>
<td colspan="1" rowspan="1" align="left" valign="top">VI</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2.62</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2,934</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">57</td>
<td colspan="1" rowspan="1" align="left" valign="top">[WGS]:AAOK00000000</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r56">56</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9917</td>
<td colspan="1" rowspan="1" align="center" valign="top">556</td>
<td colspan="1" rowspan="1" align="center" valign="top">5.1B</td>
<td colspan="1" rowspan="1" align="left" valign="top">VIII</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2.58</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2,820</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">65</td>
<td colspan="1" rowspan="1" align="left" valign="top">[WGS]:AANP00000000</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r56">56</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9916</td>
<td colspan="1" rowspan="1" align="center" valign="top">555</td>
<td colspan="1" rowspan="1" align="center" valign="top">5.1B</td>
<td colspan="1" rowspan="1" align="left" valign="top">IX</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2.66</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3,009</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">60</td>
<td colspan="1" rowspan="1" align="left" valign="top">[WGS]:AAUA00000000</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r56">56</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH5701</td>
<td colspan="1" rowspan="1" align="center" valign="top">1084</td>
<td colspan="1" rowspan="1" align="center" valign="top">5.2</td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2.86</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3,129</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">66</td>
<td colspan="1" rowspan="1" align="left" valign="top">[WGS]:AANO00000000</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r56">56</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RCC307</td>
<td colspan="1" rowspan="1" align="center" valign="top">307</td>
<td colspan="1" rowspan="1" align="center" valign="top">5.3</td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2.22</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2,583</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">61</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CT978603</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r56">56</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Prochlorococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MED4</td>
<td colspan="1" rowspan="1" align="center" valign="top">151</td>
<td colspan="1" rowspan="1" align="center" valign="top">HL</td>
<td colspan="1" rowspan="1" align="left" valign="top">HLI</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1.66</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1,716</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">31</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:BX548174</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r239">239</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9515</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">HL</td>
<td colspan="1" rowspan="1" align="left" valign="top">HLI</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1.70</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1,908</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">31</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CP000552</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r136">136</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9301</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">HL</td>
<td colspan="1" rowspan="1" align="left" valign="top">HLII</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1.64</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1,907</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">31</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CP000576</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r136">136</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> AS9601</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">HL</td>
<td colspan="1" rowspan="1" align="left" valign="top">HLII</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1.67</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1,926</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">31</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CP000551</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r136">136</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9215</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">HL</td>
<td colspan="1" rowspan="1" align="left" valign="top">HLII</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1.74</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1,989</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">31</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CP000825</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r136">136</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9312</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">HL</td>
<td colspan="1" rowspan="1" align="left" valign="top">HLII</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1.71</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1,962</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">31</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CP000111</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r136">136</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL1A</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">LL</td>
<td colspan="1" rowspan="1" align="left" valign="top">LLI</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1.86</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2,201</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">35</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CP000553</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r136">136</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL2A</td>
<td colspan="1" rowspan="1" align="center" valign="top">314</td>
<td colspan="1" rowspan="1" align="center" valign="top">LL</td>
<td colspan="1" rowspan="1" align="left" valign="top">LLI</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1.84</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2,158</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">35</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CP000095</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r136">136</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> SS120</td>
<td colspan="1" rowspan="1" align="center" valign="top">154</td>
<td colspan="1" rowspan="1" align="center" valign="top">LL</td>
<td colspan="1" rowspan="1" align="left" valign="top">LLII</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1.75</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1,884</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">36</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:AE017126</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r57">57</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9211</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">LL</td>
<td colspan="1" rowspan="1" align="left" valign="top">LLIII</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1.69</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1,855</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">38</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CP000878</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r136">136</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9303</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">LL</td>
<td colspan="1" rowspan="1" align="left" valign="top">LLIV</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2.68</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3,022</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">50</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:CP000554</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r136">136</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9313</td>
<td colspan="1" rowspan="1" align="center" valign="top">407</td>
<td colspan="1" rowspan="1" align="center" valign="top">LL</td>
<td colspan="1" rowspan="1" align="left" valign="top">LLIV</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2.41</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2,275</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">51</td>
<td colspan="1" rowspan="1" align="left" valign="top">[C]:BX548175</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r239">239</xref>
</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t1fn1"><label>a</label>
<p>RCC, Roscoff Culture Collection.</p>
</fn>
<fn id="t1fn2"><label>b</label>
<p>5.1A and 5.1B, subcluster number as defined in reference <xref ref-type="bibr" rid="r56">56</xref>
.</p>
</fn>
<fn id="t1fn3"><label>c</label>
<p>For <italic>Synechococcus</italic>
, clade number as defined in reference <xref ref-type="bibr" rid="r83">83</xref>
; for <italic>Prochlorococcus</italic>
, ecotype number as defined in reference <xref ref-type="bibr" rid="r136">136</xref>
.</p>
</fn>
<fn id="t1fn4"><label>d</label>
<p>[C]:, complete genome sequence; [WGS]:, incomplete genome sequence (estimated coverage, >99.8%).</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="t2"><label>TABLE 2.</label>
<caption><p>Overview of the broad ecological conditions under which specific picocyanobacterial clades/ecotypes are most frequent</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="1" align="center" valign="bottom">Species (subcluster) and clade</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Ecological conditions of largest relative abundance</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">References</th>
</tr>
</thead>
<tbody><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechococcus</italic>
(5.1)<xref ref-type="table-fn" rid="t2fn1"><italic>a</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> I</td>
<td colspan="1" rowspan="1" align="left" valign="top">Coastal and/or temperate mesotrophic open ocean waters largely above 30°N and below 30°S</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r34">34</xref>
, <xref ref-type="bibr" rid="r340">340</xref>
, <xref ref-type="bibr" rid="r341">341</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> II</td>
<td colspan="1" rowspan="1" align="left" valign="top">Offshore, continent shelf, oligotrophic tropical or subtropical waters between 30°N and 30°S</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r2">2</xref>
, <xref ref-type="bibr" rid="r83">83</xref>
-<xref ref-type="bibr" rid="r85">85</xref>
, <xref ref-type="bibr" rid="r294">294</xref>
, <xref ref-type="bibr" rid="r340">340</xref>
, <xref ref-type="bibr" rid="r341">341</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> III</td>
<td colspan="1" rowspan="1" align="left" valign="top">Ultraoligotrophic open-ocean waters</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r84">84</xref>
, <xref ref-type="bibr" rid="r85">85</xref>
, <xref ref-type="bibr" rid="r341">341</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> IV</td>
<td colspan="1" rowspan="1" align="left" valign="top">Coastal and/or temperate mesotrophic open ocean waters largely above 30°N and below 30°S</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r34">34</xref>
, <xref ref-type="bibr" rid="r340">340</xref>
, <xref ref-type="bibr" rid="r341">341</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> V/VI/VII<xref ref-type="table-fn" rid="t2fn2"><italic>b</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="left" valign="top">Relatively wide distribution but in low abundance in various oceanic waters; have been seen to dominate mesotrophic upwelling regions, e.g., Arabian Sea, while clade VII genotypes specifically have been shown to dominate in the Costa Rica upwelling dome</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r39">39</xref>
, <xref ref-type="bibr" rid="r84">84</xref>
, <xref ref-type="bibr" rid="r245">245</xref>
, <xref ref-type="bibr" rid="r341">341</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Prochlorococcus</italic>
</td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> HLI (eMED4)</td>
<td colspan="1" rowspan="1" align="left" valign="top">More weakly stratified surface waters, particularly between 35° and 48°N and 35° and 40°S</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r26">26</xref>
, <xref ref-type="bibr" rid="r128">128</xref>
, <xref ref-type="bibr" rid="r321">321</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> HLII (eMIT9312)</td>
<td colspan="1" rowspan="1" align="left" valign="top">Strongly stratified surface waters, particularly tropical and subtropical regions between 30°N and 30°S</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r3">3</xref>
, <xref ref-type="bibr" rid="r26">26</xref>
, <xref ref-type="bibr" rid="r128">128</xref>
, <xref ref-type="bibr" rid="r321">321</xref>
, <xref ref-type="bibr" rid="r322">322</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> LLI (eNATL2A)</td>
<td colspan="1" rowspan="1" align="left" valign="top">Occupies an “intermediate” position in the water column in stratified waters; at high latitude (above 40°N/30°S), these cells can be found throughout the euphotic zone up to the surface</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r128">128</xref>
, <xref ref-type="bibr" rid="r335">335</xref>
, <xref ref-type="bibr" rid="r336">336</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> LLIV (eMIT9313)</td>
<td colspan="1" rowspan="1" align="left" valign="top">Widely distributed within the 40°N to 35°S latitudinal range but largely restricted to the deep euphotic zone</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r84">84</xref>
, <xref ref-type="bibr" rid="r128">128</xref>
, <xref ref-type="bibr" rid="r321">321</xref>
, <xref ref-type="bibr" rid="r322">322</xref>
, <xref ref-type="bibr" rid="r335">335</xref>
, <xref ref-type="bibr" rid="r336">336</xref>
, <xref ref-type="bibr" rid="r340">340</xref>
, <xref ref-type="bibr" rid="r341">341</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> LLII (eSS120) and LLIII (eMIT9211)</td>
<td colspan="1" rowspan="1" align="left" valign="top">Present in deep waters at very low concentrations</td>
<td colspan="1" rowspan="1" align="left" valign="top"><xref ref-type="bibr" rid="r90">90</xref>
, <xref ref-type="bibr" rid="r128">128</xref>
, <xref ref-type="bibr" rid="r335">335</xref>
</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t2fn1"><label>a</label>
<p>The low levels of environmental detection of subcluster 5.1 clades VIII and IX, subcluster 5.2 (WH5701), and subcluster 5.3 (RCC307, formerly subcluster 5.1 clade X) using oligonucleotide probes thus far precludes generalizations about the ecological distributions of these clades.</p>
</fn>
<fn id="t2fn2"><label>b</label>
<p>Analyses of ecological distribution patterns for these lineages have largely used an oligonucleotide probe that detects these clades collectively.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="t3"><label>TABLE 3.</label>
<caption><p>Distribution of genes involved in ROS protection and detoxification in marine picocyanobacterial genomes</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="3" align="center" valign="middle">Genus and strain (clade)</th>
<th colspan="21" rowspan="1" align="center" valign="bottom">Presence<xref ref-type="table-fn" rid="t3fn1"><italic>a</italic>
</xref>
of:
<hr></hr>
</th>
</tr>
<tr><th colspan="1" rowspan="2" align="center" valign="middle">KatG, cluster 1897</th>
<th colspan="1" rowspan="2" align="center" valign="middle">Cu/Zn SOD, cluster 1853</th>
<th colspan="1" rowspan="2" align="center" valign="middle">Mn SOD, cluster 7995</th>
<th colspan="1" rowspan="2" align="center" valign="middle">Ni SOD, cluster 1843</th>
<th colspan="1" rowspan="2" align="center" valign="middle">Fe SOD, cluster 1824</th>
<th colspan="1" rowspan="2" align="center" valign="middle">1-Cys Prx, cluster 2925</th>
<th colspan="1" rowspan="2" align="center" valign="middle">2-Cys Prx, cluster 167</th>
<th colspan="1" rowspan="2" align="center" valign="middle">Type II Prx, cluster 3802</th>
<th colspan="1" rowspan="2" align="center" valign="middle">PrxQ, clusters 38, 812, 8024</th>
<th colspan="1" rowspan="2" align="center" valign="middle">Gpx, cluster 308</th>
<th colspan="1" rowspan="2" align="center" valign="middle">TxlA, cluster 471</th>
<th colspan="1" rowspan="2" align="center" valign="middle">GrxC<xref ref-type="table-fn" rid="t3fn3"><italic>c</italic>
</xref>
, cluster 445</th>
<th colspan="1" rowspan="2" align="center" valign="middle">Rub/HoxR, clusters 269, 3931</th>
<th colspan="1" rowspan="2" align="center" valign="middle">RbrA, cluster 1682</th>
<th colspan="1" rowspan="2" align="center" valign="middle">TrxA (m type), cluster 8028</th>
<th colspan="1" rowspan="2" align="center" valign="middle">TrxB (x type), cluster 47</th>
<th colspan="1" rowspan="2" align="center" valign="middle">Putative TrX, clusters 1171, 1233</th>
<th colspan="2" rowspan="1" align="center" valign="bottom">FTR system
<hr></hr>
</th>
<th colspan="1" rowspan="2" align="center" valign="middle">NTR system, clusters 1301, 1904</th>
<th colspan="1" rowspan="2" align="center" valign="middle">DpsA, cluster 1889</th>
</tr>
<tr><th colspan="1" rowspan="1" align="center" valign="bottom">FtrC, cluster 1648</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">FtrV, cluster 1644</th>
</tr>
</thead>
<tbody><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9311 (I)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn2"><italic>b</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9605 (II)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH8102 (III)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9902 (IV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> BL107 (IV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7803 (V)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7805 (VI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9917 (VIII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9916 (IX)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH5701 (5.2)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RCC307 (5.3)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechocystis</italic>
sp. strain PCC6803</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Prochlorococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MED4 (HLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9515 (HLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> AS9601 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9215 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9301 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9312 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL1A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL2A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> SS120 (LLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9211 (LLIII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t3fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9303 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9313 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t3fn1"><label>a</label>
<p>The presence of a single gene is indicated by a closed circle. Where multiple genes are present, the number is given. −, absent.</p>
</fn>
<fn id="t3fn2"><label>b</label>
<p>While one of these <italic>sodN</italic>
genes appears to be cyanobacterial, the other copy has an abnormal percent GC content compared with the rest of the genome and is likely the result of a horizontal gene transfer event (<xref ref-type="bibr" rid="r60">60</xref>
).</p>
</fn>
<fn id="t3fn3"><label>c</label>
<p>All marine picocyanobacteria also possess a protein containing a glutaredoxin domain and a PD1-like DNA-binding domain (cluster 178).</p>
</fn>
<fn id="t3fn4"><label>d</label>
<p>One of these proteins is a large NTR (or NTRC), i.e., thioredoxin reductase fused to a thioredoxin domain as recently identified in <italic>Arabidospis thaliana</italic>
(<xref ref-type="bibr" rid="r257">257</xref>
).</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="t4"><label>TABLE 4.</label>
<caption><p>Phyletic pattern of photolyases and DNA glycosylases potentially involved in the repair of thymine dimers in marine picocyanobacteria</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="2" align="center" valign="middle">Genus and strain (clade)</th>
<th colspan="7" rowspan="1" align="center" valign="bottom">Presence<xref ref-type="table-fn" rid="t4fn1"><italic>a</italic>
</xref>
of:
<hr></hr>
</th>
</tr>
<tr><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>phrA</italic>
, cluster 1330</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>phrB</italic>
, cluster 1584</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Photolyase-related protein, cluster 1460</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">MTFH domain, cluster 1541</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">FAD domain, cluster 1540</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">FAD domain, cluster 3563</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">PD DNA glycosylase, cluster 2679</th>
</tr>
</thead>
<tbody><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechococcus</italic>
(all strains)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Prochlorococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MED4 (HLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9515 (HLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> AS9601 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9215 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9301 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9312 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL1A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL2A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> SS120 (LLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9211 (LLIII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9303 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9313 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t4fn1"><label>a</label>
<p>•, present in single copy; −, absent.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="t5"><label>TABLE 5.</label>
<caption><p>Distribution of gene orthologs in marine picocyanobacteria encoding proteins potentially involved in compatible solute synthesis<xref ref-type="table-fn" rid="t5fn1"><italic>a</italic>
</xref>
and transport</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="2" align="center" valign="middle">Genus and strain (clade)</th>
<th colspan="16" rowspan="1" align="center" valign="bottom">Presence<xref ref-type="table-fn" rid="t5fn2"><italic>b</italic>
</xref>
of:
<hr></hr>
</th>
<th colspan="1" rowspan="2" align="center" valign="middle">Compatible solute accumulation<xref ref-type="table-fn" rid="t5fn3"><italic>c</italic>
</xref>
</th>
</tr>
<tr><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>ggpS</italic>
, cluster 1610</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>ggpP</italic>
(<italic>stpA</italic>
), cluster 1282</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>ggtA</italic>
, cluster 8069</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>ggtB</italic>
, cluster 1455</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>ggtC</italic>
, cluster 1454</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>ggtD</italic>
, cluster 1453</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>proV</italic>
, cluster 8061</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>proW</italic>
, cluster 1943</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>proX</italic>
, cluster 1944</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>gpgP</italic>
, cluster 1370</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>gpgS</italic>
, cluster 1368</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>gbmt1</italic>
, cluster 1941</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>gbmt2</italic>
, cluster 1942</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>spsA</italic>
, cluster 368</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>spp</italic>
, cluster 2483</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>betP</italic>
, cluster 1663</th>
</tr>
</thead>
<tbody><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9311 (I)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9605 (II)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH8102 (III)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="left" valign="top">GG, GB</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9902 (IV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> BL107 (IV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7803 (V)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="left" valign="top">GG, Suc, GB</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7805 (VI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9917 (VIII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9916 (IX)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH5701 (5.2)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RCC307 (5.3)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Prochlorococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="left" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MED4 (HLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9515 (HLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> AS9601 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9215 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9301 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9312 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="left" valign="top">Suc, GGA</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL1A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL2A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="left" valign="top">Suc, GGA</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> SS120 (LLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="left" valign="top">Suc, GGA</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9211 (LLIII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9303 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="left" valign="top">NI</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9313 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="left" valign="top">Suc, GB</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t5fn1"><label>a</label>
<p>No clear homolog of functionally characterized trehalose biosynthetic genes from other bacteria could be found in these marine picocyanobacterial genomes.</p>
</fn>
<fn id="t5fn2"><label>b</label>
<p>The presence of a single gene is indicated by a closed circle. Where multiple genes are present, the number is given. −, absent.</p>
</fn>
<fn id="t5fn3"><label>c</label>
<p>The ability to accumulate specific compatible solutes was analyzed by gas-liquid chromatography in ethanol extracts from selected strains (Klähn and Hagemann, unpublished data). NI, not investigated. Suc, sucrose.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="t6"><label>TABLE 6.</label>
<caption><p>Cross-genome comparison of N metabolism gene contents among <italic>Prochlorococcus</italic>
and <italic>Synechococcus</italic>
strains</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="2" align="center" valign="middle">Genus and strain (clade)</th>
<th colspan="19" rowspan="1" align="center" valign="bottom">Presence<xref ref-type="table-fn" rid="t6fn1"><italic>a</italic>
</xref>
of:
<hr></hr>
</th>
</tr>
<tr><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>ntcA</italic>
, cluster 468</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>amt</italic>
, cluster 244</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>amt</italic>
<xref ref-type="table-fn" rid="t6fn2"><italic>b</italic>
</xref>
, cluster 8701</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>glnA</italic>
, cluster 103</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>glnA</italic>
<xref ref-type="table-fn" rid="t6fn2"><italic>b</italic>
</xref>
, cluster 2090, 2505, 6741, or 8855</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>glnB</italic>
, cluster 186</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>glnB</italic>
<xref ref-type="table-fn" rid="t6fn2"><italic>b</italic>
</xref>
, cluster 2023</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>pipX</italic>
, cluster 1044</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>glsF</italic>
<xref ref-type="table-fn" rid="t6fn3"><italic>c</italic>
</xref>
, cluster 134</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>glsF</italic>
<xref ref-type="table-fn" rid="t6fn2"><italic>b</italic>
</xref>
, cluster 9009</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>gdhA</italic>
, cluster 1539 or 3700</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>ure</italic>
<xref ref-type="table-fn" rid="t6fn4"><italic>d</italic>
</xref>
, clusters 1358-1364</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>speA</italic>
, cluster 415</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>speB</italic>
, cluster 392 or 2247</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>cynS</italic>
, cluster 1552</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>carAB</italic>
, cluster 783 or 962</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>dadA</italic>
, cluster 377</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>nadB</italic>
, cluster 196</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>thiO</italic>
, cluster 417</th>
</tr>
</thead>
<tbody><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9311 (I)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•<xref ref-type="table-fn" rid="t6fn5"><italic>e</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9605 (II)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH8102 (III)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•<xref ref-type="table-fn" rid="t6fn5"><italic>e</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9902 (IV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> BL107 (IV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7803 (V)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7805 (VI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9917 (VIII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•<xref ref-type="table-fn" rid="t6fn6"><italic>f</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9916 (IX)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH5701 (5.2)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4<xref ref-type="table-fn" rid="t6fn7"><italic>g</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RCC307(5.3)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Prochlorococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MED4 (HLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9515 (HLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> AS9601 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9215 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9301 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9312 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL1A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL2A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> SS120 (LLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9211 (LLIII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9303 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9313 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t6fn1"><label>a</label>
<p>The presence of a single gene is indicated by a closed circle. Where multiple genes are present, the number is given. −, absent.</p>
</fn>
<fn id="t6fn2"><label>b</label>
<p><italic>amt</italic>
, <italic>glnA</italic>
, <italic>glnB</italic>
, and <italic>glsF</italic>
homologs.</p>
</fn>
<fn id="t6fn3"><label>c</label>
<p>Synonyms <italic>gltS</italic>
, <italic>gltB</italic>
.</p>
</fn>
<fn id="t6fn4"><label>d</label>
<p><italic>ureABCDEFG</italic>
.</p>
</fn>
<fn id="t6fn5"><label>e</label>
<p>Frameshifted ORF.</p>
</fn>
<fn id="t6fn6"><label>f</label>
<p>There is also a potential second copy of <italic>gdh</italic>
encoded by RS9917_05900 (cluster 4952).</p>
</fn>
<fn id="t6fn7"><label>g</label>
<p>One of these is interrupted by a transposase.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="t7"><label>TABLE 7.</label>
<caption><p>Distribution of P- and arsenate-related gene orthologs in marine picocyanobacteria</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="2" align="center" valign="middle">Genus and strain (clade)</th>
<th colspan="10" rowspan="1" align="center" valign="bottom">Presence<xref ref-type="table-fn" rid="t7fn1"><italic>a</italic>
</xref>
of:
<hr></hr>
</th>
</tr>
<tr><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>phoB/R</italic>
, cluster 8015/1531</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>ptrA</italic>
, cluster 1606</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>pstS</italic>
,<xref ref-type="table-fn" rid="t7fn2"><italic>b</italic>
</xref>
cluster 23(1829)</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>phoA</italic>
/5′ND<xref ref-type="table-fn" rid="t7fn3"><italic>c</italic>
</xref>
(<italic>phoX</italic>
)</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>psip1</italic>
,<xref ref-type="table-fn" rid="t7fn4"><italic>d</italic>
</xref>
cluster 2662</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>pitA</italic>
, cluster 6877</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>phoU</italic>
, cluster 5756</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>arsR</italic>
, cluster 1532</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>arsC</italic>
, cluster 1227</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>arsB</italic>
, cluster 1815</th>
</tr>
</thead>
<tbody><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9311 (I)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9605 (II)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH8102 (III)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4 (1)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4 (1)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9902 (IV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> BL107 (IV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">?<xref ref-type="table-fn" rid="t7fn5"><italic>e</italic>
</xref>
/−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7803 (V)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3 (1)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2 (1)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7805 (VI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2 (1)<xref ref-type="table-fn" rid="t7fn6"><italic>f</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9917 (VIII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">5 (2)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">(1)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9916 (IX)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH5701 (5.2)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3 (1<xref ref-type="table-fn" rid="t7fn7"><italic>g</italic>
</xref>
)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2 (1)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RCC307 (5.3)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4 (1)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">(1)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechocystis</italic>
sp. strain PCC6803</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3 (1)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Prochlorococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MED4 (HLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9515 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> AS9601 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9215 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9301 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9312 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL1A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL2A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> SS120 (LLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9211 (LLIII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9303 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−/•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3<xref ref-type="table-fn" rid="t7fn8"><italic>h</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9313 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•/Δ<xref ref-type="table-fn" rid="t7fn9"><italic>i</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t7fn1"><label>a</label>
<p>The presence of a single gene is indicated by a closed circle. Where multiple genes are present, the number is given. −, absent.</p>
</fn>
<fn id="t7fn2"><label>b</label>
<p>In parentheses is the number of gene copies phylogenetically most closely related to <italic>sphX</italic>
; a single copy of <italic>pstA</italic>
(cluster 165), <italic>pstB</italic>
(cluster 817), and <italic>pstC</italic>
(cluster 818) is present in all marine picocyanobacterial genomes except in <italic>Synechococcus</italic>
sp. strain WH7805, where two copies of <italic>pstA</italic>
exist.</p>
</fn>
<fn id="t7fn3"><label>c</label>
<p>5′ND, 5′ nucleotidase. All marine picocyanobacterial genomes so far examined also contain a <italic>dedA</italic>
-like alkaline phosphatase gene (cluster 302). The <italic>phoA</italic>
/5′ND group encompasses clusters 2917, 3430, 5181, 5416, 5811, 6036, 6582, and 9093. Another predicted phosphatase encompasses part of cluster 1164 and is related to a gene from <italic>Vibrio cholerae</italic>
AAR99475 (<italic>phoX</italic>
), the number of copies of which are indicated within parentheses.</p>
</fn>
<fn id="t7fn4"><label>d</label>
<p><italic>psip1</italic>
encodes a P starvation-inducible polypeptide of unknown function.</p>
</fn>
<fn id="t7fn5"><label>e</label>
<p>In BL107_12310 several conserved residues in PhoB are altered, potentially suggesting a change of function.</p>
</fn>
<fn id="t7fn6"><label>f</label>
<p>A predicted alkaline phosphatase gene in <italic>Synechococcus</italic>
sp. strain WH7805 contains a stop codon which introduces a frameshift, resulting in ORFs WH7805_08937 and WH7805_08942; physiological studies showed no obvious alkaline phosphatase activity in this strain (S. Mazard and D. J. Scanlan, unpublished data).</p>
</fn>
<fn id="t7fn7"><label>g</label>
<p>Another copy of <italic>sphX</italic>
in <italic>Synechococcus</italic>
sp. strain WH5701 is interrupted by a transposase.</p>
</fn>
<fn id="t7fn8"><label>h</label>
<p>One of the <italic>pstS</italic>
copies is a truncated version upstream of <italic>phoR</italic>
.</p>
</fn>
<fn id="t7fn9"><label>i</label>
<p>The <italic>phoR</italic>
gene of MIT9313 contains two frameshifts.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="t8"><label>TABLE 8.</label>
<caption><p>Distribution of Cu-related gene orthologs in marine picocyanobacterial genomes</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="2" align="center" valign="middle">Genus and strain (clade)</th>
<th colspan="6" rowspan="1" align="center" valign="bottom">Presence<xref ref-type="table-fn" rid="t8fn1"><italic>a</italic>
</xref>
of:
<hr></hr>
</th>
</tr>
<tr><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>petE</italic>
, cluster 1274</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>cueO</italic>
, cluster 2933 or 3002</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>ctaA</italic>
, cluster 65</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>pacS</italic>
, cluster 9116</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>atx1</italic>
<xref ref-type="table-fn" rid="t8fn2"><italic>b</italic>
</xref>
</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Cd/Co/Hg/Pb/Zn-translocating P-type ATPase, cluster 9115 or 9117</th>
</tr>
</thead>
<tbody><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9311 (I)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9605 (II)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH8102 (III)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9902 (IV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> BL107 (IV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7803 (V)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">• (2)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7805 (VI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9917 (VIII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9916 (IX)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH5701 (5.2)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RCC307 (5.3)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechocystis</italic>
sp. strain PCC6803</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Prochlorococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MED4 (HLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9515 (HLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> AS9601 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9215 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9301 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9312 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL1A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL2A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> SS120 (LLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9211 (LLIII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9303 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9313 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t8fn1"><label>a</label>
<p>The presence of a single gene is indicated by a closed circle. Where multiple genes are present, the number is given. −, absent.</p>
</fn>
<fn id="t8fn2"><label>b</label>
<p>Searches for Atx1 using BLASTP and TBLASTN gave TBLASTN E values in marine <italic>Synechococcus</italic>
and <italic>Prochlorococcus</italic>
strains of >0.4, so Atx1 is either absent or looks completely different from ssr2857 of <italic>Synechocystis</italic>
sp. strain PCC6803.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="t9"><label>TABLE 9.</label>
<caption><p>Distribution of Fe and Zn related gene orthologs in marine picocyanobacterial genomes</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="2" align="center" valign="middle">Genus and strain (clade)</th>
<th colspan="17" rowspan="1" align="center" valign="bottom">Presence<xref ref-type="table-fn" rid="t9fn1"><italic>a</italic>
</xref>
of:
<hr></hr>
</th>
</tr>
<tr><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>feoB</italic>
, cluster 2464</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>futA</italic>
,<xref ref-type="table-fn" rid="t9fn2"><italic>b</italic>
</xref>
cluster 68</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>futB</italic>
, cluster 639</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>futC</italic>
, cluster 8066</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Ferritin /bacterio-ferritin, cluster 1204, 2936, or 7301</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Crp1390, cluster 1390</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>dpsA</italic>
, cluster 1889</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Putative Fe-regulated hydroxylase, cluster 1755</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">PSI-associated <italic>pcb/isiA</italic>
superfamily, cluster 173/9095</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>isiB</italic>
, cluster 1833</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>fur</italic>
, cluster 956</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>zur</italic>
, cluster 397</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>fur</italic>
-type, cluster 1492</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>smtA</italic>
(Zn), cluster 2886</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>znuA</italic>
, cluster 919</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>znuA</italic>
-like, cluster 2462</th>
<th colspan="1" rowspan="1" align="center" valign="bottom"><italic>smtB</italic>
</th>
</tr>
</thead>
<tbody><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9311 (I)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">5</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9605 (II)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3<xref ref-type="table-fn" rid="t9fn3"><italic>c</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH8102 (III)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9902 (IV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> BL107 (IV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7803 (V)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7805 (VI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9917 (VIII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">?<xref ref-type="table-fn" rid="t9fn4"><italic>d</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9916 (IX)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH5701 (5.2)</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3<xref ref-type="table-fn" rid="t9fn5"><italic>e</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RCC307 (5.3)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•<xref ref-type="table-fn" rid="t9fn5"><italic>e</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechocystis</italic>
sp. strain PCC6803</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">• <italic>isiA</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Prochlorococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MED4 (HLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9515 (HLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">• <italic>pcbB</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> AS9601 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">• <italic>pcbB</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9215 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">• <italic>pcbB</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9301 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">• <italic>pcbB</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9312 (HLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">• <italic>pcbB</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL1A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">• <italic>pcbC</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL2A (LLI)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">• <italic>pcbC</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> SS120 (LLII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">• <italic>pcbC</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9211 (LLIII)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">• <italic>pcbC</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9303 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">• <italic>pcbB</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9313 (LLIV)</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">• <italic>pcbB</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">•</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
<td colspan="1" rowspan="1" align="center" valign="top">−</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t9fn1"><label>a</label>
<p>The presence of a single gene is indicated by a closed circle. Where multiple genes are present, the number is given. −, absent.</p>
</fn>
<fn id="t9fn2"><label>b</label>
<p>It is not possible to determine a homolog of <italic>futA2</italic>
(slr0513), although there are two distinct groups.</p>
</fn>
<fn id="t9fn3"><label>c</label>
<p>One copy is interrupted by a stop codon so may be a pseudogene.</p>
</fn>
<fn id="t9fn4"><label>d</label>
<p><italic>Synechococcus</italic>
sp. strain RS9917 contains two ORFs that are N- and C-terminal halves of an FeoB transporter but which are interrupted by transposase elements.</p>
</fn>
<fn id="t9fn5"><label>e</label>
<p>WH5701 and RCC307 contain a bacterioferritin most closely related to genes from heterotrophic bacteria.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="t10"><label>TABLE 10.</label>
<caption><p>Cross-genome comparison of the number of regulatory genes</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="2" align="center" valign="middle">Genus and strain (clade)</th>
<th colspan="7" rowspan="1" align="center" valign="bottom">No. of:
<hr></hr>
</th>
</tr>
<tr><th colspan="1" rowspan="1" align="center" valign="bottom">Sig70-type sigma factors<xref ref-type="table-fn" rid="t10fn1"><italic>a</italic>
</xref>
</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Type 3 alternative sigma factors</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Histidine kinases</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Response regulators</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">CRP-type regulators</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Yfr2 to -5 ncRNAs</th>
<th colspan="1" rowspan="1" align="center" valign="bottom">Yfr1 ncRNAs</th>
</tr>
</thead>
<tbody><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9311 (I)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">8</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">12</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">16</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">8</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9605 (II)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">6</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">7</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">12</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">5</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH8102 (III)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">6</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">9</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">12</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">5</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1<xref ref-type="table-fn" rid="t10fn3"><italic>c</italic>
</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> CC9902 (IV)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">6</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">8</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">11</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> BL107 (IV)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">6</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">7</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">11</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7803 (V)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">7</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">14</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">15</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH7805 (VI)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">7</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">13</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">17</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9917 (VIII)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">7</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">15</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">18</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">5</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RS9916 (IX)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">7</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">12</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">14</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> WH5701 (5.2)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">7</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">11</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">10</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> RCC307 (5.3)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">8</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">0</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">10</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">16</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Synechocystis</italic>
sp. strain PCC6803</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">5</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">47<xref ref-type="table-fn" rid="t10fn2"><italic>b</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">42</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3<xref ref-type="table-fn" rid="t10fn3"><italic>c</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1<xref ref-type="table-fn" rid="t10fn3"><italic>c</italic>
</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>Prochlorococcus</italic>
</td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
<td colspan="1" rowspan="1" align="center" valign="top"></td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MED4 (HLI)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">5</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">0</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">6</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">6</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4<xref ref-type="table-fn" rid="t10fn3"><italic>c</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1<xref ref-type="table-fn" rid="t10fn3"><italic>c</italic>
</xref>
</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9312 (HLII)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">5</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">0</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">6</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">6</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> NATL2A (LLI)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">5</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">0</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">6</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">6</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> SS120 (LLII)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">5</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">0</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">5</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">6</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">3</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1<xref ref-type="table-fn" rid="t10fn3"><italic>c</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">0</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9211 (LLIII)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">5</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">0</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">5</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">6</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">0</td>
</tr>
<tr><td colspan="1" rowspan="1" align="left" valign="top"> MIT9313 (LLIV)</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">7</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">7</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">10</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">4</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">2<xref ref-type="table-fn" rid="t10fn3"><italic>c</italic>
</xref>
</td>
<td colspan="1" rowspan="1" align="char" char="." valign="top">1<xref ref-type="table-fn" rid="t10fn3"><italic>c</italic>
</xref>
</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t10fn1"><label>a</label>
<p>Sig70-type sigma factors include SigA and the complete set of type 2 factors present in these strains.</p>
</fn>
<fn id="t10fn2"><label>b</label>
<p>The total includes 20 hybrid histidine kinases.</p>
</fn>
<fn id="t10fn3"><label>c</label>
<p>Expression and transcript start sites were verified in experiments (<xref ref-type="bibr" rid="r10">10</xref>
, <xref ref-type="bibr" rid="r309">309</xref>
).</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-wrap>
</pmc>
</record>
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