Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genotypic Diversity of Coagulase-Negative Staphylococci Causing Endocarditis: a Global Perspective<xref ref-type="fn" rid="fn1">▿</xref> </title><author><name sortKey="Petti, Cathy A" sort="Petti, Cathy A" uniqKey="Petti C" first="Cathy A." last="Petti">Cathy A. Petti</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Simmon, Keith E" sort="Simmon, Keith E" uniqKey="Simmon K" first="Keith E." last="Simmon">Keith E. Simmon</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Miro, Jose M" sort="Miro, Jose M" uniqKey="Miro J" first="Jose M." last="Miro">Jose M. Miro</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hoen, Bruno" sort="Hoen, Bruno" uniqKey="Hoen B" first="Bruno" last="Hoen">Bruno Hoen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Marco, Francesc" sort="Marco, Francesc" uniqKey="Marco F" first="Francesc" last="Marco">Francesc Marco</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chu, Vivian H" sort="Chu, Vivian H" uniqKey="Chu V" first="Vivian H." last="Chu">Vivian H. Chu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Athan, Eugene" sort="Athan, Eugene" uniqKey="Athan E" first="Eugene" last="Athan">Eugene Athan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bukovski, Suzana" sort="Bukovski, Suzana" uniqKey="Bukovski S" first="Suzana" last="Bukovski">Suzana Bukovski</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bouza, Emilio" sort="Bouza, Emilio" uniqKey="Bouza E" first="Emilio" last="Bouza">Emilio Bouza</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bradley, Suzanne" sort="Bradley, Suzanne" uniqKey="Bradley S" first="Suzanne" last="Bradley">Suzanne Bradley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Fowler, Vance G" sort="Fowler, Vance G" uniqKey="Fowler V" first="Vance G." last="Fowler">Vance G. Fowler</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Giannitsioti, Efthymia" sort="Giannitsioti, Efthymia" uniqKey="Giannitsioti E" first="Efthymia" last="Giannitsioti">Efthymia Giannitsioti</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gordon, David" sort="Gordon, David" uniqKey="Gordon D" first="David" last="Gordon">David Gordon</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Reinbott, Porl" sort="Reinbott, Porl" uniqKey="Reinbott P" first="Porl" last="Reinbott">Porl Reinbott</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Korman, Tony" sort="Korman, Tony" uniqKey="Korman T" first="Tony" last="Korman">Tony Korman</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lang, Selwyn" sort="Lang, Selwyn" uniqKey="Lang S" first="Selwyn" last="Lang">Selwyn Lang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Garcia De La Maria, Cristina" sort="Garcia De La Maria, Cristina" uniqKey="Garcia De La Maria C" first="Cristina" last="Garcia-De-La-Maria">Cristina Garcia-De-La-Maria</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Raglio, Annibale" sort="Raglio, Annibale" uniqKey="Raglio A" first="Annibale" last="Raglio">Annibale Raglio</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Morris, Arthur J" sort="Morris, Arthur J" uniqKey="Morris A" first="Arthur J." last="Morris">Arthur J. Morris</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Plesiat, Patrick" sort="Plesiat, Patrick" uniqKey="Plesiat P" first="Patrick" last="Plesiat">Patrick Plesiat</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ryan, Suzanne" sort="Ryan, Suzanne" uniqKey="Ryan S" first="Suzanne" last="Ryan">Suzanne Ryan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Doco Lecompte, Thanh" sort="Doco Lecompte, Thanh" uniqKey="Doco Lecompte T" first="Thanh" last="Doco-Lecompte">Thanh Doco-Lecompte</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Tripodi, Francesca" sort="Tripodi, Francesca" uniqKey="Tripodi F" first="Francesca" last="Tripodi">Francesca Tripodi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Utili, Riccardo" sort="Utili, Riccardo" uniqKey="Utili R" first="Riccardo" last="Utili">Riccardo Utili</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wray, Dannah" sort="Wray, Dannah" uniqKey="Wray D" first="Dannah" last="Wray">Dannah Wray</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Federspiel, J Jeffrey" sort="Federspiel, J Jeffrey" uniqKey="Federspiel J" first="J. Jeffrey" last="Federspiel">J. Jeffrey Federspiel</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Boisson, K" sort="Boisson, K" uniqKey="Boisson K" first="K." last="Boisson">K. Boisson</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Reller, L Barth" sort="Reller, L Barth" uniqKey="Reller L" first="L. Barth" last="Reller">L. Barth Reller</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Murdoch, David R" sort="Murdoch, David R" uniqKey="Murdoch D" first="David R." last="Murdoch">David R. Murdoch</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Woods, Christopher W" sort="Woods, Christopher W" uniqKey="Woods C" first="Christopher W." last="Woods">Christopher W. Woods</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18367572</idno><idno type="pmc">2395089</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395089</idno><idno type="RBID">PMC:2395089</idno><idno type="doi">10.1128/JCM.02405-07</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">001011</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001011</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genotypic Diversity of Coagulase-Negative Staphylococci Causing Endocarditis: a Global Perspective<xref ref-type="fn" rid="fn1">▿</xref> </title><author><name sortKey="Petti, Cathy A" sort="Petti, Cathy A" uniqKey="Petti C" first="Cathy A." last="Petti">Cathy A. Petti</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Simmon, Keith E" sort="Simmon, Keith E" uniqKey="Simmon K" first="Keith E." last="Simmon">Keith E. Simmon</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Miro, Jose M" sort="Miro, Jose M" uniqKey="Miro J" first="Jose M." last="Miro">Jose M. Miro</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hoen, Bruno" sort="Hoen, Bruno" uniqKey="Hoen B" first="Bruno" last="Hoen">Bruno Hoen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Marco, Francesc" sort="Marco, Francesc" uniqKey="Marco F" first="Francesc" last="Marco">Francesc Marco</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chu, Vivian H" sort="Chu, Vivian H" uniqKey="Chu V" first="Vivian H." last="Chu">Vivian H. Chu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Athan, Eugene" sort="Athan, Eugene" uniqKey="Athan E" first="Eugene" last="Athan">Eugene Athan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bukovski, Suzana" sort="Bukovski, Suzana" uniqKey="Bukovski S" first="Suzana" last="Bukovski">Suzana Bukovski</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bouza, Emilio" sort="Bouza, Emilio" uniqKey="Bouza E" first="Emilio" last="Bouza">Emilio Bouza</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bradley, Suzanne" sort="Bradley, Suzanne" uniqKey="Bradley S" first="Suzanne" last="Bradley">Suzanne Bradley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Fowler, Vance G" sort="Fowler, Vance G" uniqKey="Fowler V" first="Vance G." last="Fowler">Vance G. Fowler</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Giannitsioti, Efthymia" sort="Giannitsioti, Efthymia" uniqKey="Giannitsioti E" first="Efthymia" last="Giannitsioti">Efthymia Giannitsioti</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gordon, David" sort="Gordon, David" uniqKey="Gordon D" first="David" last="Gordon">David Gordon</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Reinbott, Porl" sort="Reinbott, Porl" uniqKey="Reinbott P" first="Porl" last="Reinbott">Porl Reinbott</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Korman, Tony" sort="Korman, Tony" uniqKey="Korman T" first="Tony" last="Korman">Tony Korman</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lang, Selwyn" sort="Lang, Selwyn" uniqKey="Lang S" first="Selwyn" last="Lang">Selwyn Lang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Garcia De La Maria, Cristina" sort="Garcia De La Maria, Cristina" uniqKey="Garcia De La Maria C" first="Cristina" last="Garcia-De-La-Maria">Cristina Garcia-De-La-Maria</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Raglio, Annibale" sort="Raglio, Annibale" uniqKey="Raglio A" first="Annibale" last="Raglio">Annibale Raglio</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Morris, Arthur J" sort="Morris, Arthur J" uniqKey="Morris A" first="Arthur J." last="Morris">Arthur J. Morris</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Plesiat, Patrick" sort="Plesiat, Patrick" uniqKey="Plesiat P" first="Patrick" last="Plesiat">Patrick Plesiat</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ryan, Suzanne" sort="Ryan, Suzanne" uniqKey="Ryan S" first="Suzanne" last="Ryan">Suzanne Ryan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Doco Lecompte, Thanh" sort="Doco Lecompte, Thanh" uniqKey="Doco Lecompte T" first="Thanh" last="Doco-Lecompte">Thanh Doco-Lecompte</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Tripodi, Francesca" sort="Tripodi, Francesca" uniqKey="Tripodi F" first="Francesca" last="Tripodi">Francesca Tripodi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Utili, Riccardo" sort="Utili, Riccardo" uniqKey="Utili R" first="Riccardo" last="Utili">Riccardo Utili</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wray, Dannah" sort="Wray, Dannah" uniqKey="Wray D" first="Dannah" last="Wray">Dannah Wray</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Federspiel, J Jeffrey" sort="Federspiel, J Jeffrey" uniqKey="Federspiel J" first="J. Jeffrey" last="Federspiel">J. Jeffrey Federspiel</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Boisson, K" sort="Boisson, K" uniqKey="Boisson K" first="K." last="Boisson">K. Boisson</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Reller, L Barth" sort="Reller, L Barth" uniqKey="Reller L" first="L. Barth" last="Reller">L. Barth Reller</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Murdoch, David R" sort="Murdoch, David R" uniqKey="Murdoch D" first="David R." last="Murdoch">David R. Murdoch</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Woods, Christopher W" sort="Woods, Christopher W" uniqKey="Woods C" first="Christopher W." last="Woods">Christopher W. Woods</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Microbiology</title><idno type="ISSN">0095-1137</idno><idno type="eISSN">1098-660X</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Coagulase-negative staphylococci (CNS) are important causes of infective endocarditis (IE), but their microbiological profiles are poorly described. We performed DNA target sequencing and susceptibility testing for 91 patients with definite CNS IE who were identified from the International Collaboration on Endocarditis—Microbiology, a large, multicenter, multinational consortium. A hierarchy of gene sequences demonstrated great genetic diversity within CNS from patients with definite endocarditis that represented diverse geographic regions. In particular, <italic>rpoB</italic> sequence data demonstrated unique genetic signatures with the potential to serve as an important tool for global surveillance.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Microbiol</journal-id><journal-id journal-id-type="publisher-id">jcm</journal-id><journal-title>Journal of Clinical Microbiology</journal-title><issn pub-type="ppub">0095-1137</issn><issn pub-type="epub">1098-660X</issn><publisher><publisher-name>American Society for Microbiology (ASM)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18367572</article-id><article-id pub-id-type="pmc">2395089</article-id><article-id pub-id-type="publisher-id">2405-07</article-id><article-id pub-id-type="doi">10.1128/JCM.02405-07</article-id><article-categories><subj-group subj-group-type="heading"><subject>Epidemiology</subject></subj-group></article-categories><title-group><article-title>Genotypic Diversity of Coagulase-Negative Staphylococci Causing Endocarditis: a Global Perspective<xref ref-type="fn" rid="fn1">▿</xref> </article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Petti</surname><given-names>Cathy A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Simmon</surname><given-names>Keith E.</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Miro</surname><given-names>Jose M.</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Hoen</surname><given-names>Bruno</given-names></name><xref ref-type="aff" rid="aff1">4</xref></contrib><contrib contrib-type="author"><name><surname>Marco</surname><given-names>Francesc</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Chu</surname><given-names>Vivian H.</given-names></name><xref ref-type="aff" rid="aff1">5</xref></contrib><contrib contrib-type="author"><name><surname>Athan</surname><given-names>Eugene</given-names></name><xref ref-type="aff" rid="aff1">7</xref></contrib><contrib contrib-type="author"><name><surname>Bukovski</surname><given-names>Suzana</given-names></name><xref ref-type="aff" rid="aff1">8</xref></contrib><contrib contrib-type="author"><name><surname>Bouza</surname><given-names>Emilio</given-names></name><xref ref-type="aff" rid="aff1">9</xref></contrib><contrib contrib-type="author"><name><surname>Bradley</surname><given-names>Suzanne</given-names></name><xref ref-type="aff" rid="aff1">10</xref></contrib><contrib contrib-type="author"><name><surname>Fowler</surname><given-names>Vance G.</given-names></name><xref ref-type="aff" rid="aff1">5</xref></contrib><contrib contrib-type="author"><name><surname>Giannitsioti</surname><given-names>Efthymia</given-names></name><xref ref-type="aff" rid="aff1">11</xref></contrib><contrib contrib-type="author"><name><surname>Gordon</surname><given-names>David</given-names></name><xref ref-type="aff" rid="aff1">12</xref></contrib><contrib contrib-type="author"><name><surname>Reinbott</surname><given-names>Porl</given-names></name><xref ref-type="aff" rid="aff1">13</xref></contrib><contrib contrib-type="author"><name><surname>Korman</surname><given-names>Tony</given-names></name><xref ref-type="aff" rid="aff1">14</xref></contrib><contrib contrib-type="author"><name><surname>Lang</surname><given-names>Selwyn</given-names></name><xref ref-type="aff" rid="aff1">15</xref></contrib><contrib contrib-type="author"><name><surname>Garcia-de-la-Maria</surname><given-names>Cristina</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Raglio</surname><given-names>Annibale</given-names></name><xref ref-type="aff" rid="aff1">16</xref></contrib><contrib contrib-type="author"><name><surname>Morris</surname><given-names>Arthur J.</given-names></name><xref ref-type="aff" rid="aff1">17</xref></contrib><contrib contrib-type="author"><name><surname>Plesiat</surname><given-names>Patrick</given-names></name><xref ref-type="aff" rid="aff1">4</xref></contrib><contrib contrib-type="author"><name><surname>Ryan</surname><given-names>Suzanne</given-names></name><xref ref-type="aff" rid="aff1">18</xref></contrib><contrib contrib-type="author"><name><surname>Doco-Lecompte</surname><given-names>Thanh</given-names></name><xref ref-type="aff" rid="aff1">19</xref></contrib><contrib contrib-type="author"><name><surname>Tripodi</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="aff1">20</xref></contrib><contrib contrib-type="author"><name><surname>Utili</surname><given-names>Riccardo</given-names></name><xref ref-type="aff" rid="aff1">20</xref></contrib><contrib contrib-type="author"><name><surname>Wray</surname><given-names>Dannah</given-names></name><xref ref-type="aff" rid="aff1">21</xref></contrib><contrib contrib-type="author"><name><surname>Federspiel</surname><given-names>J. Jeffrey</given-names></name><xref ref-type="aff" rid="aff1">5</xref></contrib><contrib contrib-type="author"><name><surname>Boisson</surname><given-names>K.</given-names></name><xref ref-type="aff" rid="aff1">4</xref></contrib><contrib contrib-type="author"><name><surname>Reller</surname><given-names>L. Barth</given-names></name><xref ref-type="aff" rid="aff1">5</xref></contrib><contrib contrib-type="author"><name><surname>Murdoch</surname><given-names>David R.</given-names></name><xref ref-type="aff" rid="aff1">22</xref></contrib><contrib contrib-type="author"><name><surname>Woods</surname><given-names>Christopher W.</given-names></name><xref ref-type="aff" rid="aff1">5</xref><xref ref-type="aff" rid="aff1">6</xref></contrib><contrib contrib-type="author"><collab>and the International Collaboration on Endocarditis—Microbiology Investigators</collab></contrib></contrib-group><aff id="aff1">Departments of Medicine and Pathology, University of Utah School of Medicine, Salt Lake City, Utah,<label>1</label> ARUP Laboratories, Salt Lake City, Utah,<label>2</label> Hospital Clinic Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain,<label>3</label> University Medical Center of Besançon, Besançon, France,<label>4</label> Duke University Medical Center,<label>5</label> Veterans Administration Medical Center, Durham, North Carolina,<label>6</label> Barwon Health, Geelong, Australia,<label>7</label> University Hospital for Infectious Disease, Zagreb, Croatia,<label>8</label> Hospital General Universitario Gregorio Marañón, Madrid, Spain,<label>9</label> Veterans Administration Medical Center, Ann Arbor, Michigan,<label>10</label> Attikon University General Hospital, Athens, Greece,<label>11</label> Flinders Medical Centre, Adelaide, Australia,<label>12</label> The University of South Wales, Sydney, Australia,<label>13</label> Southern Health, Clayton, Australia,<label>14</label> Middlemore Hospital, Auckland, New Zealand,<label>15</label> Ospedali Riuniti di Bergamo, Bergamo, Italy,<label>16</label> Auckland City Hospital, Auckland, New Zealand,<label>17</label> South Eastern Sydney and Illawarra Area Health Service, Australia,<label>18</label> CHU Nancy-Brabois, Nancy, France,<label>19</label> Second University of Naples, Naples, Italy,<label>20</label> Medical University of South Carolina, Charleston, South Carolina,<label>21</label> University of Otago, Christchurch, New Zealand<label>22</label></aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address: University of Utah School of Medicine, ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108. Phone: (801) 583-2787. Fax: (801) 584-5207. E-mail: <email>cathy.petti@aruplab.com</email></p></fn></author-notes><pub-date pub-type="ppub"><month>5</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>26</day><month>3</month><year>2008</year></pub-date><volume>46</volume><issue>5</issue><fpage>1780</fpage><lpage>1784</lpage><history><date date-type="received"><day>16</day><month>12</month><year>2007</year></date><date date-type="rev-recd"><day>26</day><month>2</month><year>2008</year></date><date date-type="accepted"><day>14</day><month>3</month><year>2008</year></date></history><permissions><copyright-statement>Copyright © 2008, American Society for Microbiology</copyright-statement></permissions><self-uri xlink:title="pdf" xlink:href="zjm00508001780.pdf"></self-uri><abstract><p>Coagulase-negative staphylococci (CNS) are important causes of infective endocarditis (IE), but their microbiological profiles are poorly described. We performed DNA target sequencing and susceptibility testing for 91 patients with definite CNS IE who were identified from the International Collaboration on Endocarditis—Microbiology, a large, multicenter, multinational consortium. A hierarchy of gene sequences demonstrated great genetic diversity within CNS from patients with definite endocarditis that represented diverse geographic regions. In particular, <italic>rpoB</italic> sequence data demonstrated unique genetic signatures with the potential to serve as an important tool for global surveillance.</p></abstract></article-meta></front><floats-wrap><fig position="float" id="f1"><label>FIG. 1.</label><caption><p>Neighbor-joining radial dendrograms of the 16S rRNA (A), <italic>tuf</italic> (B), and <italic>rpoB</italic> (C) genes of CNS isolates from patients with endocarditis. Each entry represents a unique sequence among the study isolates. The number of isolates sharing 100% identity with the representative sequence is noted. Intraspecies variability is recorded as the percent difference between isolates of the same species, as well as the number of base pair positions in the interrogated sequence with instability. To the side of each tree, the relative distance from each species to its nearest neighbor is recorded in terms of percent distance. A superscript letter <italic>a</italic> indicates two isolates identified by Microscan as <italic>S. hominis</italic> subsp. <italic>novobiosepticus</italic> that had unique <italic>tuf</italic> and <italic>rpoB</italic> sequences which differed by at least 4 bp (0.6%) and 2 bp (0.3%) from the other <italic>S. hominis</italic> sequences, respectively. A superscript letter <italic>b</italic> indicates rifampin-resistant isolates.</p></caption><graphic xlink:href="zjm0050881230001"></graphic></fig><table-wrap position="float" id="t1"><label>TABLE 1.</label><caption><p>Identification by conventional method and gene sequencing</p></caption><table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="2" align="center" valign="middle">Final identification by phylogenetic resolution (no. of isolates)</th><th colspan="4" rowspan="1" align="center" valign="bottom">Identity according to following test method:
<hr></hr></th></tr><tr><th colspan="1" rowspan="1" align="center" valign="bottom">Conventional<xref ref-type="table-fn" rid="t1fn1"><italic>a</italic></xref></th><th colspan="1" rowspan="1" align="center" valign="bottom">16S rRNA</th><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>tuf</italic></th><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>rpoB</italic></th></tr></thead><tbody><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic> (59)</td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic> (3)</td><td colspan="1" rowspan="1" align="left" valign="top"><italic><bold>S. hominis</bold></italic><bold>subsp.</bold><italic><bold>hominis</bold></italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic> (1)</td><td colspan="1" rowspan="1" align="left" valign="top"><italic><bold>S. capitis</bold></italic><bold>subsp.</bold><italic><bold>urealyticus</bold></italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic> (1)</td><td colspan="1" rowspan="1" align="left" valign="top"><italic><bold>S. hyicus</bold></italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic> (1)</td><td colspan="1" rowspan="1" align="left" valign="top"><italic><bold>S. warneri</bold></italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. epidermidis</italic></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. lugdunensis</italic> (8)</td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. lugdunensis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. lugdunensis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. lugdunensis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. lugdunensis</italic></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. hominis</italic> (6)</td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. hominis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. hominis</italic>/<italic>xylosus</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. hominis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. hominis</italic></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. haemolyticus</italic> (3)</td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. haemolyticus</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. haemolyticus</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. haemolyticus</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. haemolyticus</italic></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. capitis</italic> (5)</td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. capitis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. capitis</italic>/<italic>caprae</italic>/<italic>arlettae</italic>/<italic>epidermidis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. capitis</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. capitis</italic></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. schleiferi</italic> (1)</td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. schleiferi</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. schleiferi</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>Staphylococcus</italic> sp.</td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. schleiferi</italic></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. aureus</italic> (1)</td><td colspan="1" rowspan="1" align="left" valign="top"><italic><bold>S. epidermidis</bold></italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. aureus</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. aureus</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. aureus</italic></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. pasteuri</italic> (1)</td><td colspan="1" rowspan="1" align="left" valign="top"><italic><bold>S. warneri</bold></italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. pasteuri</italic>/<italic>aureus</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>Staphylococcus</italic> sp.</td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. pasteuri</italic></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. warneri</italic> (1)</td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. warneri</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. warneri</italic>/<italic>pasteuri</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. warneri</italic></td><td colspan="1" rowspan="1" align="left" valign="top"><italic>S. warneri</italic></td></tr></tbody></table><table-wrap-foot><fn id="t1fn1"><label>a</label><p>Boldface type indicates misidentification by conventional methods.</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="t2"><label>TABLE 2.</label><caption><p>Distribution of antimicrobial susceptibilities of CNS isolates</p></caption><table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="2" align="center" valign="middle">Antibacterial agent and MIC (μg/ml)<xref ref-type="table-fn" rid="t2fn1"><italic>a</italic></xref></th><th colspan="8" rowspan="1" align="center" valign="bottom">No. of isolates identified by <italic>rpoB</italic> sequence as:
<hr></hr></th></tr><tr><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>S. epidermidis</italic> (<italic>n</italic> = 65)</th><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>S. lugdunensis</italic> (<italic>n</italic> = 8)</th><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>S. hominis</italic> (<italic>n</italic> = 6)</th><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>S. capitis</italic> (<italic>n</italic> = 5)</th><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>S. haemolyticus</italic> (<italic>n</italic> = 3)</th><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>S. pasteuri</italic> (<italic>n</italic> = 1)</th><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>S. schleiferi</italic> (<italic>n</italic> = 1)</th><th colspan="1" rowspan="1" align="center" valign="bottom"><italic>S. warneri</italic> (<italic>n</italic> = 1)</th></tr></thead><tbody><tr><td colspan="1" rowspan="1" align="left" valign="top">Oxacillin</td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"> ≤0.25</td><td colspan="1" rowspan="1" align="char" char="." valign="top">26</td><td colspan="1" rowspan="1" align="char" char="." valign="top">5</td><td colspan="1" rowspan="1" align="char" char="." valign="top">2</td><td colspan="1" rowspan="1" align="char" char="." valign="top">3</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"> <bold>0.5</bold><xref ref-type="table-fn" rid="t2fn2"><italic>b</italic></xref></td><td colspan="1" rowspan="1" align="char" char="." valign="top">2</td><td colspan="1" rowspan="1" align="char" char="." valign="top">3</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"> 1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"> ≥2</td><td colspan="1" rowspan="1" align="char" char="." valign="top">36</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">3</td><td colspan="1" rowspan="1" align="char" char="." valign="top">2</td><td colspan="1" rowspan="1" align="char" char="." valign="top">2</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">Vancomycin</td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"> ≤1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">27</td><td colspan="1" rowspan="1" align="char" char="." valign="top">8</td><td colspan="1" rowspan="1" align="char" char="." valign="top">4</td><td colspan="1" rowspan="1" align="char" char="." valign="top">4</td><td colspan="1" rowspan="1" align="char" char="." valign="top">2</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"> 2</td><td colspan="1" rowspan="1" align="char" char="." valign="top">38</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">2</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">Linezolid</td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"> ≤0.5</td><td colspan="1" rowspan="1" align="char" char="." valign="top">46</td><td colspan="1" rowspan="1" align="char" char="." valign="top">7</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">3</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"> 1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">17</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">6</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">2</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"> 2</td><td colspan="1" rowspan="1" align="char" char="." valign="top">2</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">Daptomycin, ≤1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">65</td><td colspan="1" rowspan="1" align="char" char="." valign="top">8</td><td colspan="1" rowspan="1" align="char" char="." valign="top">6</td><td colspan="1" rowspan="1" align="char" char="." valign="top">5</td><td colspan="1" rowspan="1" align="char" char="." valign="top">3</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">Rifampin</td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td><td colspan="1" rowspan="1" align="char" char="." valign="top"></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"> ≤1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">57</td><td colspan="1" rowspan="1" align="char" char="." valign="top">8</td><td colspan="1" rowspan="1" align="char" char="." valign="top">6</td><td colspan="1" rowspan="1" align="char" char="." valign="top">5</td><td colspan="1" rowspan="1" align="char" char="." valign="top">3</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td><td colspan="1" rowspan="1" align="char" char="." valign="top">1</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"> 2</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top"> <bold>≥4</bold></td><td colspan="1" rowspan="1" align="char" char="." valign="top">8</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td><td colspan="1" rowspan="1" align="char" char="." valign="top">0</td></tr></tbody></table><table-wrap-foot><fn id="t2fn1"><label>a</label><p>Breakpoints for susceptibility are those defined by the Clinical and Laboratory Standards Institute (<xref ref-type="bibr" rid="r8">8</xref>). An MIC in boldface type represents the breakpoint for resistance.</p></fn><fn id="t2fn2"><label>b</label><p>The breakpoint for <italic>S. lugdunensis</italic> oxacillin resistance is ≥4 μg/ml.</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="t3"><label>TABLE 3.</label><caption><p>Variability of the <italic>rpoB</italic> amino acid sequence for <italic>S. epidermidis</italic> isolates<xref ref-type="table-fn" rid="t3fn1"><italic>a</italic></xref></p></caption><table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="1" align="center" valign="bottom">No. of isolates</th><th colspan="1" rowspan="1" align="center" valign="bottom">Nucleotide change(s) in <italic>rpoB</italic></th><th colspan="1" rowspan="1" align="center" valign="bottom">Amino acid alteration</th><th colspan="1" rowspan="1" align="center" valign="bottom">Rifampin resistance (MIC [μg/ml])</th></tr></thead><tbody><tr><td colspan="1" rowspan="1" align="center" valign="top">55</td><td colspan="1" rowspan="1" align="left" valign="top">None</td><td colspan="1" rowspan="1" align="left" valign="top">None</td><td colspan="1" rowspan="1" align="left" valign="top">Susceptible (<1)</td></tr><tr><td colspan="1" rowspan="1" align="center" valign="top">1</td><td colspan="1" rowspan="1" align="left" valign="top">GCT → GAT</td><td colspan="1" rowspan="1" align="left" valign="top">A534 → D</td><td colspan="1" rowspan="1" align="left" valign="top">Susceptible (<1)</td></tr><tr><td colspan="1" rowspan="1" align="center" valign="top">1</td><td colspan="1" rowspan="1" align="left" valign="top">CGT → CAT</td><td colspan="1" rowspan="1" align="left" valign="top">R503 → H</td><td colspan="1" rowspan="1" align="left" valign="top">Susceptible (<1)</td></tr><tr><td colspan="1" rowspan="1" align="center" valign="top">1</td><td colspan="1" rowspan="1" align="left" valign="top">GAT → TAC</td><td colspan="1" rowspan="1" align="left" valign="top">D471 → Y<xref ref-type="table-fn" rid="t3fn2"><italic>b</italic></xref></td><td colspan="1" rowspan="1" align="left" valign="top">Resistant (>32)</td></tr><tr><td colspan="1" rowspan="1" align="center" valign="top"></td><td colspan="1" rowspan="1" align="left" valign="top">CAC → AAC</td><td colspan="1" rowspan="1" align="left" valign="top">H481 → N<xref ref-type="table-fn" rid="t3fn2"><italic>b</italic></xref></td><td colspan="1" rowspan="1" align="left" valign="top"></td></tr><tr><td colspan="1" rowspan="1" align="center" valign="top">1</td><td colspan="1" rowspan="1" align="left" valign="top">CAC → AAC</td><td colspan="1" rowspan="1" align="left" valign="top">H481 → N<xref ref-type="table-fn" rid="t3fn2"><italic>b</italic></xref></td><td colspan="1" rowspan="1" align="left" valign="top">Resistant (>32)</td></tr><tr><td colspan="1" rowspan="1" align="center" valign="top"></td><td colspan="1" rowspan="1" align="left" valign="top">ATA → ATG</td><td colspan="1" rowspan="1" align="left" valign="top">I527 → M<xref ref-type="table-fn" rid="t3fn2"><italic>b</italic></xref></td><td colspan="1" rowspan="1" align="left" valign="top"></td></tr><tr><td colspan="1" rowspan="1" align="center" valign="top">6</td><td colspan="1" rowspan="1" align="left" valign="top">GAT → GAA</td><td colspan="1" rowspan="1" align="left" valign="top">D471 → E<xref ref-type="table-fn" rid="t3fn2"><italic>b</italic></xref></td><td colspan="1" rowspan="1" align="left" valign="top">Resistant (>32)</td></tr><tr><td colspan="1" rowspan="1" align="center" valign="top"></td><td colspan="1" rowspan="1" align="left" valign="top">ATA → ATG</td><td colspan="1" rowspan="1" align="left" valign="top">I527 → M<xref ref-type="table-fn" rid="t3fn2"><italic>b</italic></xref></td><td colspan="1" rowspan="1" align="left" valign="top"></td></tr></tbody></table><table-wrap-foot><fn id="t3fn1"><label>a</label><p>Amino acid sequences of the <italic>rpoB</italic> gene were compared to GenBank sequence <ext-link ext-link-type="gen" xlink:href="NP_763861">NP_763861</ext-link> (ATCC 12228).</p></fn><fn id="t3fn2"><label>b</label><p>Regions known to be involved with resistance to rifampin (<xref ref-type="bibr" rid="r15">15</xref>).</p></fn></table-wrap-foot></table-wrap></floats-wrap></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001011 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001011 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |