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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Stress-induced decrease in TRAF2 stability is mediated by Siah2</title><author><name sortKey="Habelhah, Hasem" sort="Habelhah, Hasem" uniqKey="Habelhah H" first="Hasem" last="Habelhah">Hasem Habelhah</name></author><author><name sortKey="Frew, Ian J" sort="Frew, Ian J" uniqKey="Frew I" first="Ian J." last="Frew">Ian J. Frew</name><affiliation><nlm:aff id="N0x9a7ddc8.0x998b8c0"></nlm:aff></affiliation></author><author><name sortKey="Laine, Aaron" sort="Laine, Aaron" uniqKey="Laine A" first="Aaron" last="Laine">Aaron Laine</name></author><author><name sortKey="Janes, Peter W" sort="Janes, Peter W" uniqKey="Janes P" first="Peter W." last="Janes">Peter W. Janes</name><affiliation><nlm:aff id="N0x9a7ddc8.0x998b8c0"></nlm:aff></affiliation></author><author><name sortKey="Relaix, Frederic" sort="Relaix, Frederic" uniqKey="Relaix F" first="Frederic" last="Relaix">Frederic Relaix</name><affiliation><nlm:aff id="N0x9a7ddc8.0x998b8c0"></nlm:aff></affiliation></author><author><name sortKey="Sassoon, David" sort="Sassoon, David" uniqKey="Sassoon D" first="David" last="Sassoon">David Sassoon</name><affiliation><nlm:aff id="N0x9a7ddc8.0x998b8c0"></nlm:aff></affiliation></author><author><name sortKey="Bowtell, David D L" sort="Bowtell, David D L" uniqKey="Bowtell D" first="David D. L." last="Bowtell">David D. L. Bowtell</name><affiliation><nlm:aff id="N0x9a7ddc8.0x998b8c0"></nlm:aff></affiliation></author><author><name sortKey="Ronai, Ze V" sort="Ronai, Ze V" uniqKey="Ronai Z" first="Ze V" last="Ronai">Ze V Ronai</name><affiliation><nlm:aff id="N0x9a7ddc8.0x998b8c0"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">12411493</idno><idno type="pmc">131073</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC131073</idno><idno type="RBID">PMC:131073</idno><idno type="doi">10.1093/emboj/cdf576</idno><date when="2002">2002</date><idno type="wicri:Area/Pmc/Corpus">000F75</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Stress-induced decrease in TRAF2 stability is mediated by Siah2</title><author><name sortKey="Habelhah, Hasem" sort="Habelhah, Hasem" uniqKey="Habelhah H" first="Hasem" last="Habelhah">Hasem Habelhah</name></author><author><name sortKey="Frew, Ian J" sort="Frew, Ian J" uniqKey="Frew I" first="Ian J." last="Frew">Ian J. Frew</name><affiliation><nlm:aff id="N0x9a7ddc8.0x998b8c0"></nlm:aff></affiliation></author><author><name sortKey="Laine, Aaron" sort="Laine, Aaron" uniqKey="Laine A" first="Aaron" last="Laine">Aaron Laine</name></author><author><name sortKey="Janes, Peter W" sort="Janes, Peter W" uniqKey="Janes P" first="Peter W." last="Janes">Peter W. Janes</name><affiliation><nlm:aff id="N0x9a7ddc8.0x998b8c0"></nlm:aff></affiliation></author><author><name sortKey="Relaix, Frederic" sort="Relaix, Frederic" uniqKey="Relaix F" first="Frederic" last="Relaix">Frederic Relaix</name><affiliation><nlm:aff id="N0x9a7ddc8.0x998b8c0"></nlm:aff></affiliation></author><author><name sortKey="Sassoon, David" sort="Sassoon, David" uniqKey="Sassoon D" first="David" last="Sassoon">David Sassoon</name><affiliation><nlm:aff id="N0x9a7ddc8.0x998b8c0"></nlm:aff></affiliation></author><author><name sortKey="Bowtell, David D L" sort="Bowtell, David D L" uniqKey="Bowtell D" first="David D. L." last="Bowtell">David D. L. Bowtell</name><affiliation><nlm:aff id="N0x9a7ddc8.0x998b8c0"></nlm:aff></affiliation></author><author><name sortKey="Ronai, Ze V" sort="Ronai, Ze V" uniqKey="Ronai Z" first="Ze V" last="Ronai">Ze V Ronai</name><affiliation><nlm:aff id="N0x9a7ddc8.0x998b8c0"></nlm:aff></affiliation></author></analytic><series><title level="j">The EMBO Journal</title><idno type="ISSN">0261-4189</idno><idno type="eISSN">1460-2075</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>TRAF2 serves as a central regulator of the cellular response to stress and cytokines through the regulation of key stress-signaling cascades. Here we demonstrate that wild-type, but not RING mutant, Siah2 targets TRAF2 for ubiquitylation and degradation <italic>in vitro</italic>. Siah2 mediates equally efficient ubiquitylation of RING mutant TRAF2. <italic>In vivo</italic>, Siah2 primarily targets TRAF2 for degradation under stress conditions. Tumor necrosis factor-α (TNF-α) and actinomycin D treatment results in accelerated TRAF2 degradation in wild-type mouse embryo fibroblasts (MEFs), as compared with <italic>Siah2</italic><sup>–/–</sup> cells. Similarly, TRAF2 half-life is prolonged in <italic>Siah2</italic><sup>–/–</sup> compared with wild-type MEFs subjected to stress stimuli. Siah2 efficiently decreases TNF-α-dependent induction of JNK activity and transcriptional activation of NF-κB. Apoptosis induced by TNF-α and actinomycin D treatment is increased upon expression of Siah2, or attenuated upon expression of TRAF2 or RING mutant Siah2. Identifying Siah2 as a regulator of TRAF2 stability reveals its role in the regulation of TRAF2 signaling following exposure to stress.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">EMBO J</journal-id><journal-title>The EMBO Journal</journal-title><issn pub-type="ppub">0261-4189</issn><issn pub-type="epub">1460-2075</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>Oxford, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">12411493</article-id><article-id pub-id-type="pmc">131073</article-id><article-id pub-id-type="publisher-id">cdf576</article-id><article-id pub-id-type="doi">10.1093/emboj/cdf576</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Stress-induced decrease in TRAF2 stability is mediated by Siah2</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Habelhah</surname><given-names>Hasem</given-names></name></contrib><contrib contrib-type="author"><name><surname>Frew</surname><given-names>Ian J.</given-names></name><xref ref-type="aff" rid="N0x9a7ddc8.0x998b8c0">1</xref></contrib><contrib contrib-type="author"><name><surname>Laine</surname><given-names>Aaron</given-names></name></contrib><contrib contrib-type="author"><name><surname>Janes</surname><given-names>Peter W.</given-names></name><xref ref-type="aff" rid="N0x9a7ddc8.0x998b8c0">1</xref></contrib><contrib contrib-type="author"><name><surname>Relaix</surname><given-names>Frederic</given-names></name><xref ref-type="aff" rid="N0x9a7ddc8.0x998b8c0">2</xref></contrib><contrib contrib-type="author"><name><surname>Sassoon</surname><given-names>David</given-names></name><xref ref-type="aff" rid="N0x9a7ddc8.0x998b8c0">3</xref></contrib><contrib contrib-type="author"><name><surname>Bowtell</surname><given-names>David D.L.</given-names></name><xref ref-type="aff" rid="N0x9a7ddc8.0x998b8c0">1</xref></contrib><contrib contrib-type="author"><name><surname>Ronai</surname><given-names>Ze’ev</given-names></name><xref ref-type="aff" rid="N0x9a7ddc8.0x998b8c0">4</xref></contrib></contrib-group><aff id="N0x9a7ddc8.0x998b8c0">Ruttenberg Cancer Center and<label>3</label>Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA,<label>1</label>Peter MacCallum Cancer Institute, Melbourne 3002, Victoria, Australia and<label>2</label>Department of Molecular Biology, Institute Pasteur, 75724 Paris, France<label>4</label>Corresponding author e-mail:<email>zeev.ronai@mssm.edu</email></aff><pub-date pub-type="ppub"><day>1</day><month>11</month><year>2002</year></pub-date><volume>21</volume><issue>21</issue><fpage>5756</fpage><lpage>5765</lpage><ext-link ext-link-type="uri" xlink:href="http://www.emboj.oupjournals.org/content/vol21/issue21/"></ext-link><history><date date-type="received"><day>7</day><month>6</month><year>2002</year></date><date date-type="rev-recd"><day>21</day><month>8</month><year>2002</year></date><date date-type="accepted"><day>10</day><month>9</month><year>2002</year></date></history><copyright-statement>Copyright © 2002 European Molecular Biology Organization</copyright-statement><copyright-year>2002</copyright-year><abstract><p>TRAF2 serves as a central regulator of the cellular response to stress and cytokines through the regulation of key stress-signaling cascades. Here we demonstrate that wild-type, but not RING mutant, Siah2 targets TRAF2 for ubiquitylation and degradation <italic>in vitro</italic>. Siah2 mediates equally efficient ubiquitylation of RING mutant TRAF2. <italic>In vivo</italic>, Siah2 primarily targets TRAF2 for degradation under stress conditions. Tumor necrosis factor-α (TNF-α) and actinomycin D treatment results in accelerated TRAF2 degradation in wild-type mouse embryo fibroblasts (MEFs), as compared with <italic>Siah2</italic><sup>–/–</sup> cells. Similarly, TRAF2 half-life is prolonged in <italic>Siah2</italic><sup>–/–</sup> compared with wild-type MEFs subjected to stress stimuli. Siah2 efficiently decreases TNF-α-dependent induction of JNK activity and transcriptional activation of NF-κB. Apoptosis induced by TNF-α and actinomycin D treatment is increased upon expression of Siah2, or attenuated upon expression of TRAF2 or RING mutant Siah2. Identifying Siah2 as a regulator of TRAF2 stability reveals its role in the regulation of TRAF2 signaling following exposure to stress.</p></abstract><kwd-group><kwd>JNK/NF-κB/Siah2/stress/TRAF2</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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