Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Detection of Influenza Viruses Resistant to Neuraminidase Inhibitors in Global Surveillance during the First 3 Years of Their Use</title><author><name sortKey="Monto, Arnold S" sort="Monto, Arnold S" uniqKey="Monto A" first="Arnold S." last="Monto">Arnold S. Monto</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mckimm Breschkin, Jennifer L" sort="Mckimm Breschkin, Jennifer L" uniqKey="Mckimm Breschkin J" first="Jennifer L." last="Mckimm-Breschkin">Jennifer L. Mckimm-Breschkin</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Macken, Catherine" sort="Macken, Catherine" uniqKey="Macken C" first="Catherine" last="Macken">Catherine Macken</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hampson, Alan W" sort="Hampson, Alan W" uniqKey="Hampson A" first="Alan W." last="Hampson">Alan W. Hampson</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hay, Alan" sort="Hay, Alan" uniqKey="Hay A" first="Alan" last="Hay">Alan Hay</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Klimov, Alexander" sort="Klimov, Alexander" uniqKey="Klimov A" first="Alexander" last="Klimov">Alexander Klimov</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Aymard, Michelle" sort="Aymard, Michelle" uniqKey="Aymard M" first="Michelle" last="Aymard">Michelle Aymard</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zambon, Maria" sort="Zambon, Maria" uniqKey="Zambon M" first="Maria" last="Zambon">Maria Zambon</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16801417</idno><idno type="pmc">1489772</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489772</idno><idno type="RBID">PMC:1489772</idno><idno type="doi">10.1128/AAC.01339-05</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000F54</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F54</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Detection of Influenza Viruses Resistant to Neuraminidase Inhibitors in Global Surveillance during the First 3 Years of Their Use</title><author><name sortKey="Monto, Arnold S" sort="Monto, Arnold S" uniqKey="Monto A" first="Arnold S." last="Monto">Arnold S. Monto</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mckimm Breschkin, Jennifer L" sort="Mckimm Breschkin, Jennifer L" uniqKey="Mckimm Breschkin J" first="Jennifer L." last="Mckimm-Breschkin">Jennifer L. Mckimm-Breschkin</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Macken, Catherine" sort="Macken, Catherine" uniqKey="Macken C" first="Catherine" last="Macken">Catherine Macken</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hampson, Alan W" sort="Hampson, Alan W" uniqKey="Hampson A" first="Alan W." last="Hampson">Alan W. Hampson</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hay, Alan" sort="Hay, Alan" uniqKey="Hay A" first="Alan" last="Hay">Alan Hay</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Klimov, Alexander" sort="Klimov, Alexander" uniqKey="Klimov A" first="Alexander" last="Klimov">Alexander Klimov</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Aymard, Michelle" sort="Aymard, Michelle" uniqKey="Aymard M" first="Michelle" last="Aymard">Michelle Aymard</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zambon, Maria" sort="Zambon, Maria" uniqKey="Zambon M" first="Maria" last="Zambon">Maria Zambon</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Antimicrobial Agents and Chemotherapy</title><idno type="ISSN">0066-4804</idno><idno type="eISSN">1098-6596</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Emergence of influenza viruses with reduced susceptibility to neuraminidase inhibitors (NAIs) develops at a low level following drug treatment, and person-to-person transmission of resistant virus has not been recognized to date. The Neuraminidase Inhibitor Susceptibility Network (NISN) was established to follow susceptibility of isolates and occurrence of NAI resistance at a population level in various parts of the world. Isolates from the WHO influenza collaborating centers were screened for susceptibilities to oseltamivir and zanamivir by a chemiluminescent enzyme inhibition assay, and those considered potentially resistant were analyzed by sequence analysis of the neuraminidase genes. During the first 3 years of NAI use (1999 to 2002), 2,287 isolates were tested. Among them, eight (0.33%) viruses had a >10-fold decrease in susceptibility to oseltamivir, one (0.22%) in 1999 to 2000, three (0.36%) in 2000 to 2001, and four (0.41%) in 2001 to 2002. Six had unique changes in the neuraminidase gene compared to neuraminidases of the same subtype in the influenza sequence database. Although only one of the mutations had previously been recognized in persons receiving NAIs, none were from patients who were known to have received the drugs. During the 3 years preceding NAI use, no resistant variants were detected among 1,054 viruses. Drug use was relatively stable during the period, except for an approximate 10-fold increase in oseltamivir use in Japan during the third year. The frequency of variants with decreased sensitivity to the NAIs did not increase significantly during this period, but continued surveillance is required, especially in regions with higher NAI use.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Antimicrob Agents Chemother</journal-id><journal-id journal-id-type="publisher-id">aac</journal-id><journal-title>Antimicrobial Agents and Chemotherapy</journal-title><issn pub-type="ppub">0066-4804</issn><issn pub-type="epub">1098-6596</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16801417</article-id><article-id pub-id-type="pmc">1489772</article-id><article-id pub-id-type="publisher-id">1339-05</article-id><article-id pub-id-type="doi">10.1128/AAC.01339-05</article-id><article-categories><subj-group subj-group-type="heading"><subject>Antiviral Agents</subject></subj-group></article-categories><title-group><article-title>Detection of Influenza Viruses Resistant to Neuraminidase Inhibitors in Global Surveillance during the First 3 Years of Their Use</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Monto</surname><given-names>Arnold S.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>McKimm-Breschkin</surname><given-names>Jennifer L.</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Macken</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Hampson</surname><given-names>Alan W.</given-names></name><xref ref-type="aff" rid="aff1">4</xref></contrib><contrib contrib-type="author"><name><surname>Hay</surname><given-names>Alan</given-names></name><xref ref-type="aff" rid="aff1">5</xref></contrib><contrib contrib-type="author"><name><surname>Klimov</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="aff1">6</xref></contrib><contrib contrib-type="author"><name><surname>Tashiro</surname><given-names>Masato</given-names></name><xref ref-type="aff" rid="aff1">7</xref></contrib><contrib contrib-type="author"><name><surname>Webster</surname><given-names>Robert G.</given-names></name><xref ref-type="aff" rid="aff1">8</xref></contrib><contrib contrib-type="author"><name><surname>Aymard</surname><given-names>Michelle</given-names></name><xref ref-type="aff" rid="aff1">9</xref></contrib><contrib contrib-type="author"><name><surname>Hayden</surname><given-names>Frederick G.</given-names></name><xref ref-type="aff" rid="aff1">10</xref></contrib><contrib contrib-type="author"><name><surname>Zambon</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="aff1">11</xref></contrib></contrib-group><aff id="aff1">University of Michigan School of Public Health, Ann Arbor, Michigan,<label>1</label> CSIRO Molecular and Health Technologies, Parkville, Australia,<label>2</label> Los Alamos National Laboratory, Los Alamos, New Mexico,<label>3</label> WHO Collaborating Centre for Reference & Research on Influenza, Melbourne, Australia,<label>4</label> WHO Collaborating Center for Reference & Research on Influenza, National Institute for Medical Research, Mill Hill, London, United Kingdom,<label>5</label> WHO Collaborating Center for Surveillance, Epidemiology and Control of Influenza, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, Georgia,<label>6</label> WHO Collaborating Center for Reference & Research on Influenza, National Institute of Infectious Diseases, Tokyo, Japan,<label>7</label> WHO Collaborating Center for the Studies on the Ecology of Influenza in Animals and Birds, St. Jude Children's Research Hospital, Memphis, Tennessee,<label>8</label> Universit é Claude Bernard, Lyon, France,<label>9</label> University of Virginia School of Medicine, Charlottesville, Virginia,<label>10</label> Health Protection Agency, Colindale, London, United Kingdom<label>11</label></aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address: School of Public Health, University of Michigan, 109 Observatory Street, Ann Arbor, MI 48109. Phone: (734) 764-5453. Fax: (734) 764-3192. E-mail: <email>asmonto@umich.edu</email>.</p></fn></author-notes><pub-date pub-type="ppub"><month>7</month><year>2006</year></pub-date><volume>50</volume><issue>7</issue><fpage>2395</fpage><lpage>2402</lpage><history><date date-type="received"><day>12</day><month>10</month><year>2005</year></date><date date-type="rev-recd"><day>6</day><month>1</month><year>2006</year></date><date date-type="accepted"><day>20</day><month>4</month><year>2006</year></date></history><copyright-statement>Copyright © 2006, American Society for Microbiology</copyright-statement><copyright-year>2006</copyright-year><self-uri xlink:title="pdf" xlink:href="zac00706002395.pdf"></self-uri><abstract><p>Emergence of influenza viruses with reduced susceptibility to neuraminidase inhibitors (NAIs) develops at a low level following drug treatment, and person-to-person transmission of resistant virus has not been recognized to date. The Neuraminidase Inhibitor Susceptibility Network (NISN) was established to follow susceptibility of isolates and occurrence of NAI resistance at a population level in various parts of the world. Isolates from the WHO influenza collaborating centers were screened for susceptibilities to oseltamivir and zanamivir by a chemiluminescent enzyme inhibition assay, and those considered potentially resistant were analyzed by sequence analysis of the neuraminidase genes. During the first 3 years of NAI use (1999 to 2002), 2,287 isolates were tested. Among them, eight (0.33%) viruses had a >10-fold decrease in susceptibility to oseltamivir, one (0.22%) in 1999 to 2000, three (0.36%) in 2000 to 2001, and four (0.41%) in 2001 to 2002. Six had unique changes in the neuraminidase gene compared to neuraminidases of the same subtype in the influenza sequence database. Although only one of the mutations had previously been recognized in persons receiving NAIs, none were from patients who were known to have received the drugs. During the 3 years preceding NAI use, no resistant variants were detected among 1,054 viruses. Drug use was relatively stable during the period, except for an approximate 10-fold increase in oseltamivir use in Japan during the third year. The frequency of variants with decreased sensitivity to the NAIs did not increase significantly during this period, but continued surveillance is required, especially in regions with higher NAI use.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F549 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000F549 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |