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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">5-Nitroimidazole Drugs Effective against Metronidazole-Resistant <italic>Trichomonas vaginalis</italic> and <italic>Giardia duodenalis</italic></title><author><name sortKey="Upcroft, Jacqueline A" sort="Upcroft, Jacqueline A" uniqKey="Upcroft J" first="Jacqueline A." last="Upcroft">Jacqueline A. Upcroft</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dunn, Linda A" sort="Dunn, Linda A" uniqKey="Dunn L" first="Linda A." last="Dunn">Linda A. Dunn</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wright, Janelle M" sort="Wright, Janelle M" uniqKey="Wright J" first="Janelle M." last="Wright">Janelle M. Wright</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Benakli, Kamel" sort="Benakli, Kamel" uniqKey="Benakli K" first="Kamel" last="Benakli">Kamel Benakli</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Upcroft, Peter" sort="Upcroft, Peter" uniqKey="Upcroft P" first="Peter" last="Upcroft">Peter Upcroft</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Vanelle, Patrice" sort="Vanelle, Patrice" uniqKey="Vanelle P" first="Patrice" last="Vanelle">Patrice Vanelle</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16377707</idno><idno type="pmc">1346785</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1346785</idno><idno type="RBID">PMC:1346785</idno><idno type="doi">10.1128/AAC.50.1.344-347.2006</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000F52</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">5-Nitroimidazole Drugs Effective against Metronidazole-Resistant <italic>Trichomonas vaginalis</italic> and <italic>Giardia duodenalis</italic></title><author><name sortKey="Upcroft, Jacqueline A" sort="Upcroft, Jacqueline A" uniqKey="Upcroft J" first="Jacqueline A." last="Upcroft">Jacqueline A. Upcroft</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dunn, Linda A" sort="Dunn, Linda A" uniqKey="Dunn L" first="Linda A." last="Dunn">Linda A. Dunn</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wright, Janelle M" sort="Wright, Janelle M" uniqKey="Wright J" first="Janelle M." last="Wright">Janelle M. Wright</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Benakli, Kamel" sort="Benakli, Kamel" uniqKey="Benakli K" first="Kamel" last="Benakli">Kamel Benakli</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Upcroft, Peter" sort="Upcroft, Peter" uniqKey="Upcroft P" first="Peter" last="Upcroft">Peter Upcroft</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Vanelle, Patrice" sort="Vanelle, Patrice" uniqKey="Vanelle P" first="Patrice" last="Vanelle">Patrice Vanelle</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Antimicrobial Agents and Chemotherapy</title><idno type="ISSN">0066-4804</idno><idno type="eISSN">1098-6596</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Metronidazole (Mz)-resistant <italic>Giardia</italic> and <italic>Trichomonas</italic> were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-resistance among established 5-nitromidazole antiparasitic drugs.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Antimicrob Agents Chemother</journal-id><journal-id journal-id-type="publisher-id">aac</journal-id><journal-title>Antimicrobial Agents and Chemotherapy</journal-title><issn pub-type="ppub">0066-4804</issn><issn pub-type="epub">1098-6596</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16377707</article-id><article-id pub-id-type="pmc">1346785</article-id><article-id pub-id-type="publisher-id">0692-05</article-id><article-id pub-id-type="doi">10.1128/AAC.50.1.344-347.2006</article-id><article-categories><subj-group subj-group-type="heading"><subject>Susceptibility</subject></subj-group></article-categories><title-group><article-title>5-Nitroimidazole Drugs Effective against Metronidazole-Resistant <italic>Trichomonas vaginalis</italic> and <italic>Giardia duodenalis</italic></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Upcroft</surname><given-names>Jacqueline A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Dunn</surname><given-names>Linda A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>Janelle M.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Benakli</surname><given-names>Kamel</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Upcroft</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Vanelle</surname><given-names>Patrice</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib></contrib-group><aff id="aff1">Queensland Institute of Medical Research and ACITHN, 300 Herston Rd., Brisbane, Queensland 4006, Australia,<label>1</label> School of Population Health, University of Queensland, Brisbane, Queensland 4072, Australia,<label>2</label> Laboratoire de Chimie Organique Pharmaceutique, LCOP-UMR CNRS 6517, Université de la Méditerranée, Faculté de Pharmacie, 27 Bd. J Moulin, 13385 Marseille Cedex 05, France<label>3</label></aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address: The Queensland Institute of Medical Research, P.O. Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. Phone: 61 7 3362 0369. Fax: 61 7 3362 0105. E-mail: <email>Jacqui.Upcroft@qimr.edu.au</email>.</p></fn></author-notes><pub-date pub-type="ppub"><month>1</month><year>2006</year></pub-date><volume>50</volume><issue>1</issue><fpage>344</fpage><lpage>347</lpage><history><date date-type="received"><day>1</day><month>6</month><year>2005</year></date><date date-type="rev-recd"><day>22</day><month>6</month><year>2005</year></date><date date-type="accepted"><day>12</day><month>10</month><year>2005</year></date></history><copyright-statement>Copyright © 2006, American Society for Microbiology</copyright-statement><copyright-year>2006</copyright-year><abstract><p>Metronidazole (Mz)-resistant <italic>Giardia</italic> and <italic>Trichomonas</italic> were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-resistance among established 5-nitromidazole antiparasitic drugs.</p></abstract><custom-meta-wrap><custom-meta><meta-name>PDF filename</meta-name><meta-value>zac00106000344</meta-value></custom-meta></custom-meta-wrap></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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