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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Limited Polymorphism in the Dihydropteroate Synthetase Gene (<italic>dhps</italic>) of <italic>Plasmodium vivax</italic> Isolates from Thailand</title><author><name sortKey="Imwong, Mallika" sort="Imwong, Mallika" uniqKey="Imwong M" first="Mallika" last="Imwong">Mallika Imwong</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Pukrittayakamee, Sasithon" sort="Pukrittayakamee, Sasithon" uniqKey="Pukrittayakamee S" first="Sasithon" last="Pukrittayakamee">Sasithon Pukrittayakamee</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Cheng, Qin" sort="Cheng, Qin" uniqKey="Cheng Q" first="Qin" last="Cheng">Qin Cheng</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Moore, Catrin" sort="Moore, Catrin" uniqKey="Moore C" first="Catrin" last="Moore">Catrin Moore</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Looareesuwan, Sornchai" sort="Looareesuwan, Sornchai" uniqKey="Looareesuwan S" first="Sornchai" last="Looareesuwan">Sornchai Looareesuwan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Snounou, Georges" sort="Snounou, Georges" uniqKey="Snounou G" first="Georges" last="Snounou">Georges Snounou</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="White, Nicholas J" sort="White, Nicholas J" uniqKey="White N" first="Nicholas J." last="White">Nicholas J. White</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Day, Nicholas P J" sort="Day, Nicholas P J" uniqKey="Day N" first="Nicholas P. J." last="Day">Nicholas P. J. Day</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16189131</idno><idno type="pmc">1251524</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1251524</idno><idno type="RBID">PMC:1251524</idno><idno type="doi">10.1128/AAC.49.10.4393-4395.2005</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000F51</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Limited Polymorphism in the Dihydropteroate Synthetase Gene (<italic>dhps</italic>) of <italic>Plasmodium vivax</italic> Isolates from Thailand</title><author><name sortKey="Imwong, Mallika" sort="Imwong, Mallika" uniqKey="Imwong M" first="Mallika" last="Imwong">Mallika Imwong</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Pukrittayakamee, Sasithon" sort="Pukrittayakamee, Sasithon" uniqKey="Pukrittayakamee S" first="Sasithon" last="Pukrittayakamee">Sasithon Pukrittayakamee</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Cheng, Qin" sort="Cheng, Qin" uniqKey="Cheng Q" first="Qin" last="Cheng">Qin Cheng</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Moore, Catrin" sort="Moore, Catrin" uniqKey="Moore C" first="Catrin" last="Moore">Catrin Moore</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Looareesuwan, Sornchai" sort="Looareesuwan, Sornchai" uniqKey="Looareesuwan S" first="Sornchai" last="Looareesuwan">Sornchai Looareesuwan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Snounou, Georges" sort="Snounou, Georges" uniqKey="Snounou G" first="Georges" last="Snounou">Georges Snounou</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="White, Nicholas J" sort="White, Nicholas J" uniqKey="White N" first="Nicholas J." last="White">Nicholas J. White</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Day, Nicholas P J" sort="Day, Nicholas P J" uniqKey="Day N" first="Nicholas P. J." last="Day">Nicholas P. J. Day</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Antimicrobial Agents and Chemotherapy</title><idno type="ISSN">0066-4804</idno><idno type="eISSN">1098-6596</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The <italic>dhps</italic> sequences of 55 <italic>Plasmodium vivax</italic> isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pv<italic>dhps</italic> at codons 383 and/or 553 (A → G) in 33 isolates, all from Thailand. Mutations of Pv<italic>dhps</italic> and Pv<italic>dhfr</italic> were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Antimicrob Agents Chemother</journal-id><journal-id journal-id-type="publisher-id">aac</journal-id><journal-title>Antimicrobial Agents and Chemotherapy</journal-title><issn pub-type="ppub">0066-4804</issn><issn pub-type="epub">1098-6596</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16189131</article-id><article-id pub-id-type="pmc">1251524</article-id><article-id pub-id-type="publisher-id">0403-05</article-id><article-id pub-id-type="doi">10.1128/AAC.49.10.4393-4395.2005</article-id><article-categories><subj-group subj-group-type="heading"><subject>Mechanisms of Resistance</subject></subj-group></article-categories><title-group><article-title>Limited Polymorphism in the Dihydropteroate Synthetase Gene (<italic>dhps</italic>) of <italic>Plasmodium vivax</italic> Isolates from Thailand</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Imwong</surname><given-names>Mallika</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pukrittayakamee</surname><given-names>Sasithon</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Cheng</surname><given-names>Qin</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Moore</surname><given-names>Catrin</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Looareesuwan</surname><given-names>Sornchai</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Snounou</surname><given-names>Georges</given-names></name><xref ref-type="aff" rid="aff1">4</xref></contrib><contrib contrib-type="author"><name><surname>White</surname><given-names>Nicholas J.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">3</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Day</surname><given-names>Nicholas P. J.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">3</xref></contrib></contrib-group><aff id="aff1">Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand,<label>1</label> Drug Resistance and Diagnostics Department, Australian Army Malaria Institute, Brisbane, Queensland, Australia,<label>2</label> Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom,<label>3</label> Unité de Parasitologie Biomédicale, CNRS URA 2581, Institut Pasteur, Paris, France<label>4</label></aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address: Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand. Phone: 66 2 354 9172. Fax: 66 2 354 9169. E-mail: <email>nickw@tropmedres.ac</email>.</p></fn></author-notes><pub-date pub-type="ppub"><month>10</month><year>2005</year></pub-date><volume>49</volume><issue>10</issue><fpage>4393</fpage><lpage>4395</lpage><history><date date-type="received"><day>30</day><month>3</month><year>2005</year></date><date date-type="rev-recd"><day>12</day><month>5</month><year>2005</year></date><date date-type="accepted"><day>21</day><month>7</month><year>2005</year></date></history><copyright-statement>Copyright © 2005, American Society for Microbiology</copyright-statement><copyright-year>2005</copyright-year><abstract><p>The <italic>dhps</italic> sequences of 55 <italic>Plasmodium vivax</italic> isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pv<italic>dhps</italic> at codons 383 and/or 553 (A → G) in 33 isolates, all from Thailand. Mutations of Pv<italic>dhps</italic> and Pv<italic>dhfr</italic> were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance.</p></abstract><custom-meta-wrap><custom-meta><meta-name>PDF filename</meta-name><meta-value>zac01005004393</meta-value></custom-meta></custom-meta-wrap></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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