ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle
Identifieur interne : 000E78 ( Pmc/Corpus ); précédent : 000E77; suivant : 000E79ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle
Auteurs : J. Bousquet ; P. W. Hellings ; I. Agache ; A. Bedbrook ; C. Bachert ; K. C. Bergmann ; M. Bewick ; C. Bindslev-Jensen ; S. Bosnic-Anticevitch ; C. Bucca ; D. P. Caimmi ; P. A. M. Camargos ; G. W. Canonica ; T. Casale ; N. H. Chavannes ; A. A. Cruz ; G. De Carlo ; R. Dahl ; P. Demoly ; P. Devillier ; J. Fonseca ; W. J. Fokkens ; N. A. Guldemond ; T. Haahtela ; M. Illario ; J. Just ; T. Keil ; L. Klimek ; P. Kuna ; D. Larenas-Linnemann ; M. Morais-Almeida ; J. Mullol ; R. Murray ; R. Naclerio ; R. E. O Ehir ; N. G. Papadopoulos ; R. Pawankar ; P. Potter ; D. Ryan ; B. Samolinski ; H. J. Schunemann ; A. Sheikh ; F. E. R. Simons ; C. Stellato ; A. Todo-Bom ; P. V. Tomazic ; A. Valiulis ; E. Valovirta ; M. T. Ventura ; M. Wickman ; I. Young ; A. Yorgancioglu ; T. Zuberbier ; W. Aberer ; C. A. Akdis ; M. Akdis ; I. Annesi-Maesano ; J. Ankri ; I. J. Ansotegui ; J. M. Anto ; S. Arnavielhe ; A. Asarnoj ; H. Arshad ; F. Avolio ; I. Baiardini ; C. Barbara ; M. Barbagallo ; E. D. Bateman ; B. Beghé ; E. H. Bel ; K. S. Bennoor ; M. Benson ; A. Z. Białoszewski ; T. Bieber ; L. Bjermer ; H. Blain ; F. Blasi ; A. L. Boner ; M. Bonini ; S. Bonini ; I. Bosse ; J. Bouchard ; L. P. Boulet ; R. Bourret ; P. J. Bousquet ; F. Braido ; A. H. Briggs ; C. E. Brightling ; J. Brozek ; R. Buhl ; C. Bunu ; E. Burte ; A. Bush ; F. Caballero-Fonseca ; M. A. Calderon ; T. Camuzat ; V. Cardona ; P. Carreiro-Martins ; A. M. Carriazo ; K. H. Carlsen ; W. Carr ; A. M. Cepeda Sarabia ; M. Cesari ; L. Chatzi ; R. Chiron ; T. Chivato ; E. Chkhartishvili ; A. G. Chuchalin ; K. F. Chung ; G. Ciprandi ; J. Correia De Sousa ; L. Cox ; G. Crooks ; A. Custovic ; S. E. Dahlen ; U. Darsow ; T. Dedeu ; D. Deleanu ; J. A. Denburg ; G. De Vries ; A. Didier ; A. T. Dinh-Xuan ; D. Dokic ; H. Douagui ; G. Dray ; R. Dubakiene ; S. R. Durham ; G. Du Toit ; M. S. Dykewicz ; P. Eklund ; Y. El-Gamal ; E. Ellers ; R. Emuzyte ; J. Farrell ; A. Fink Wagner ; A. Fiocchi ; M. Fletcher ; F. Forastiere ; M. Gaga ; A. Gamkrelidze ; B. Gemicio Lu ; J. E. Gereda ; R. Gerth Van Wick ; S. González Diaz ; I. Grisle ; L. Grouse ; Z. Gutter ; M. A. Guzmán ; B. Hellquist-Dahl ; J. Heinrich ; F. Horak ; J. O B. Hourihane ; M. Humbert ; M. Hyland ; G. Iaccarino ; E. J. Jares ; C. Jeandel ; S. L. Johnston ; G. Joos ; O. Jonquet ; K. S. Jung ; M. Jutel ; I. Kaidashev ; M. Khaitov ; O. Kalayci ; A. F. Kalyoncu ; P. Kardas ; P. K. Keith ; M. Kerkhof ; H. A. M. Kerstjens ; N. Khaltaev ; M. Kogevinas ; V. Kolek ; G. H. Koppelman ; M. L. Kowalski ; M. Kuitunen ; I. Kull ; V. Kvedariene ; B. Lambrecht ; S. Lau ; D. Laune ; L. T. T. Le ; P. Lieberman ; B. Lipworth ; J. Li ; K. C. Lodrup Carlsen ; R. Louis ; C. Lupinek ; W. Macnee ; Y. Magar ; A. Magnan ; B. Mahboub ; D. Maier ; I. Majer ; J. Malva ; P. Manning ; E. De Manuel Keenoy ; G. D. Marshall ; M. R. Masjedi ; E. Mathieu-Dupas ; M. Maurer ; S. Mavale-Manuel ; E. Melén ; E. Melo-Gomes ; E. O. Meltzer ; J. Mercier ; H. Merk ; N. Miculinic ; F. Mihaltan ; B. Milenkovic ; J. Millot-Keurinck ; Y. Mohammad ; I. Momas ; R. Mösges ; A. Muraro ; L. Namazova-Baranova ; R. Nadif ; H. Neffen ; K. Nekam ; A. Nieto ; B. Niggemann ; L. Nogueira-Silva ; M. Nogues ; T. D. Nyembue ; K. Ohta ; Y. Okamoto ; K. Okubo ; M. Olive-Elias ; S. Ouedraogo ; P. Paggiaro ; I. Pali-Schöll ; S. Palkonen ; P. Panzner ; A. Papi ; H. S. Park ; G. Passalacqua ; S. Pedersen ; A. M. Pereira ; O. Pfaar ; R. Picard ; B. Pigearias ; I. Pin ; D. Plavec ; W. Pohl ; T. A. Popov ; F. Portejoie ; D. Postma ; L. K. Poulsen ; D. Price ; K. F. Rabe ; F. Raciborski ; G. Roberts ; C. Robalo-Cordeiro ; F. Rodenas ; L. Rodriguez-Ma As ; C. Rolland ; M. Roman Rodriguez ; A. Romano ; J. Rosado-Pinto ; N. Rosario ; M. Rottem ; M. Sanchez-Borges ; J. Sastre-Dominguez ; G. K. Scadding ; N. Scichilone ; P. Schmid-Grendelmeier ; E. Serrano ; M. Shields ; V. Siroux ; J. C. Sisul ; I. Skrindo ; H. A. Smit ; D. Solé ; T. Sooronbaev ; O. Spranger ; R. Stelmach ; P. J. Sterk ; T. Strandberg ; J. Sunyer ; C. Thijs ; M. Triggiani ; R. Valenta ; A. Valero ; M. Van Eerd ; E. Van Ganse ; M. Van Hague ; O. Vandenplas ; L. L. Varona ; B. Vellas ; G. Vezzani ; T. Vazankari ; G. Viegi ; T. Vontetsianos ; M. Wagenmann ; S. Walker ; D. Y. Wang ; U. Wahn ; T. Werfel ; B. Whalley ; D. M. Williams ; S. Williams ; N. Wilson ; J. Wright ; B. P. Yawn ; P. K. Yiallouros ; O. M. Yusuf ; A. Zaidi ; H. J. Zar ; M. E. Zernotti ; L. Zhang ; N. Zhong ; M. ZidarnSource :
- Clinical and Translational Allergy [ 2045-7022 ] ; 2016.
Abstract
The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA—disseminated and implemented in over 70 countries globally—is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (
Url:
DOI: 10.1186/s13601-016-0137-4
PubMed: 28050247
PubMed Central: 5203711
Links to Exploration step
PMC:5203711Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle</title><author><name sortKey="Bousquet, J" sort="Bousquet, J" uniqKey="Bousquet J" first="J." last="Bousquet">J. Bousquet</name><affiliation><nlm:aff id="Aff1">Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2">MACVIA-France, Contre les MAladies Chroniques pour un VIeillissement Actif en France, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3">INSERM, U1168, Ageing and Chronic Diseases Epidemiological and Public Health Approaches, 94800 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff312">CHRU Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France</nlm:aff></affiliation></author><author><name sortKey="Hellings, P W" sort="Hellings, P W" uniqKey="Hellings P" first="P. W." last="Hellings">P. W. Hellings</name><affiliation><nlm:aff id="Aff4">Laboratory of Clinical Immunology, Department of Microbiology and Immunology, KU Leuven, Louvain, Belgium</nlm:aff></affiliation></author><author><name sortKey="Agache, I" sort="Agache, I" uniqKey="Agache I" first="I." last="Agache">I. Agache</name><affiliation><nlm:aff id="Aff5">Transylvania University Brasov, Brasov, Romania</nlm:aff></affiliation></author><author><name sortKey="Bedbrook, A" sort="Bedbrook, A" uniqKey="Bedbrook A" first="A." last="Bedbrook">A. Bedbrook</name><affiliation><nlm:aff id="Aff2">MACVIA-France, Contre les MAladies Chroniques pour un VIeillissement Actif en France, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Bachert, C" sort="Bachert, C" uniqKey="Bachert C" first="C." last="Bachert">C. Bachert</name><affiliation><nlm:aff id="Aff6">Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Bergmann, K C" sort="Bergmann, K C" uniqKey="Bergmann K" first="K. C." last="Bergmann">K. C. Bergmann</name><affiliation><nlm:aff id="Aff7">Allergy-Centre-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff8">Global Allergy and Asthma European Network (GA²LEN), Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Bewick, M" sort="Bewick, M" uniqKey="Bewick M" first="M." last="Bewick">M. Bewick</name><affiliation><nlm:aff id="Aff9">iQ4U Consultants Ltd, London, UK</nlm:aff></affiliation></author><author><name sortKey="Bindslev Jensen, C" sort="Bindslev Jensen, C" uniqKey="Bindslev Jensen C" first="C." last="Bindslev-Jensen">C. Bindslev-Jensen</name><affiliation><nlm:aff id="Aff10">Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bosnic Anticevitch, S" sort="Bosnic Anticevitch, S" uniqKey="Bosnic Anticevitch S" first="S." last="Bosnic-Anticevitch">S. Bosnic-Anticevitch</name><affiliation><nlm:aff id="Aff11">Woolcock Institute of Medical Research, University of Sydney and Sydney Local Health District, Glebe, NSW Australia</nlm:aff></affiliation></author><author><name sortKey="Bucca, C" sort="Bucca, C" uniqKey="Bucca C" first="C." last="Bucca">C. Bucca</name><affiliation><nlm:aff id="Aff12">University Pneumology Unit-AOU Molinette, Hospital City of Health and Science of Torino, Turin, Italy</nlm:aff></affiliation></author><author><name sortKey="Caimmi, D P" sort="Caimmi, D P" uniqKey="Caimmi D" first="D. P." last="Caimmi">D. P. Caimmi</name><affiliation><nlm:aff id="Aff13">Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Camargos, P A M" sort="Camargos, P A M" uniqKey="Camargos P" first="P. A. M." last="Camargos">P. A. M. Camargos</name><affiliation><nlm:aff id="Aff14">Department of Pediatrics, Medical School, Federal University of Minas Gerais, Belo Horizonte, Brazil</nlm:aff></affiliation></author><author><name sortKey="Canonica, G W" sort="Canonica, G W" uniqKey="Canonica G" first="G. W." last="Canonica">G. W. Canonica</name><affiliation><nlm:aff id="Aff15">Asthma and Allergy Clinic, Humanitas University, Rozzano, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Casale, T" sort="Casale, T" uniqKey="Casale T" first="T." last="Casale">T. Casale</name><affiliation><nlm:aff id="Aff16">Division of Allergy/Immunology, University of South Florida, Tampa, FL USA</nlm:aff></affiliation></author><author><name sortKey="Chavannes, N H" sort="Chavannes, N H" uniqKey="Chavannes N" first="N. H." last="Chavannes">N. H. Chavannes</name><affiliation><nlm:aff id="Aff17">Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cruz, A A" sort="Cruz, A A" uniqKey="Cruz A" first="A. A." last="Cruz">A. A. Cruz</name><affiliation><nlm:aff id="Aff18">ProAR – Nucleo de Excelencia em Asma, Federal University of Bahia, Salvador, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="Aff19">GARD Executive Committee, Salvador, Bahia Brazil</nlm:aff></affiliation></author><author><name sortKey="De Carlo, G" sort="De Carlo, G" uniqKey="De Carlo G" first="G." last="De Carlo">G. De Carlo</name><affiliation><nlm:aff id="Aff20">EFA European Federation of Allergy and Airways Diseases Patients’ Associations, Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Dahl, R" sort="Dahl, R" uniqKey="Dahl R" first="R." last="Dahl">R. Dahl</name><affiliation><nlm:aff id="Aff18">ProAR – Nucleo de Excelencia em Asma, Federal University of Bahia, Salvador, Brazil</nlm:aff></affiliation></author><author><name sortKey="Demoly, P" sort="Demoly, P" uniqKey="Demoly P" first="P." last="Demoly">P. Demoly</name><affiliation><nlm:aff id="Aff13">Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff21">EPAR U707 INSERM, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff22">EPAR UMR-S UPMC, Paris VI, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Devillier, P" sort="Devillier, P" uniqKey="Devillier P" first="P." last="Devillier">P. Devillier</name><affiliation><nlm:aff id="Aff23">Laboratoire de Pharmacologie Respiratoire UPRES EA220, Hôpital Foch, Suresnes Université Versailles, Saint-Quentin, France</nlm:aff></affiliation></author><author><name sortKey="Fonseca, J" sort="Fonseca, J" uniqKey="Fonseca J" first="J." last="Fonseca">J. Fonseca</name><affiliation><nlm:aff id="Aff24">Center for Research in Health Technologies and Information Systems - CINTESIS, Universidade do Porto, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff25">Allergy Unit, Instituto CUF Porto e Hospital CUF Porto, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff26">Health Information and Decision Sciences Department - CIDES, Faculdade de Medicina, Universidade do Porto, Rua Dr. Plácido da Costa, s/n, 4200-450 Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Fokkens, W J" sort="Fokkens, W J" uniqKey="Fokkens W" first="W. J." last="Fokkens">W. J. Fokkens</name><affiliation><nlm:aff id="Aff27">Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Guldemond, N A" sort="Guldemond, N A" uniqKey="Guldemond N" first="N. A." last="Guldemond">N. A. Guldemond</name><affiliation><nlm:aff id="Aff28">Institute of Health Policy and Management IBMG, Erasmus University, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Haahtela, T" sort="Haahtela, T" uniqKey="Haahtela T" first="T." last="Haahtela">T. Haahtela</name><affiliation><nlm:aff id="Aff29">Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Illario, M" sort="Illario, M" uniqKey="Illario M" first="M." last="Illario">M. Illario</name><affiliation><nlm:aff id="Aff30">Federico II University Hospital Naples (R&D and DISMET), Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Just, J" sort="Just, J" uniqKey="Just J" first="J." last="Just">J. Just</name><affiliation><nlm:aff id="Aff31">Allergology Department, Centre de l’Asthme et des Allergies, Hôpital d’Enfants Armand-Trousseau (APHP), Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Equipe EPAR, 75013 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Keil, T" sort="Keil, T" uniqKey="Keil T" first="T." last="Keil">T. Keil</name><affiliation><nlm:aff id="Aff32">Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff33">Institute for Clinical Epidemiology and Biometry, University of Wuerzburg, Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Klimek, L" sort="Klimek, L" uniqKey="Klimek L" first="L." last="Klimek">L. Klimek</name><affiliation><nlm:aff id="Aff34">Center for Rhinology and Allergology, Wiesbaden, Germany</nlm:aff></affiliation></author><author><name sortKey="Kuna, P" sort="Kuna, P" uniqKey="Kuna P" first="P." last="Kuna">P. Kuna</name><affiliation><nlm:aff id="Aff35">Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland</nlm:aff></affiliation></author><author><name sortKey="Larenas Linnemann, D" sort="Larenas Linnemann, D" uniqKey="Larenas Linnemann D" first="D." last="Larenas-Linnemann">D. Larenas-Linnemann</name><affiliation><nlm:aff id="Aff36">Clínica de Alergia, Asma y Pediatría, Hospital Médica Sur, Mexico City, Mexico</nlm:aff></affiliation></author><author><name sortKey="Morais Almeida, M" sort="Morais Almeida, M" uniqKey="Morais Almeida M" first="M." last="Morais-Almeida">M. Morais-Almeida</name><affiliation><nlm:aff id="Aff37">Allergy and Clinical Immunology Department, Hospital CUF-Descobertas, Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Mullol, J" sort="Mullol, J" uniqKey="Mullol J" first="J." last="Mullol">J. Mullol</name><affiliation><nlm:aff id="Aff38">ENT Department, Hospital Clinic, Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, Universitat de Barcelona, Barcelona, Catalonia Spain</nlm:aff></affiliation></author><author><name sortKey="Murray, R" sort="Murray, R" uniqKey="Murray R" first="R." last="Murray">R. Murray</name><affiliation><nlm:aff id="Aff39">MedScript Ltd, Dundalk, County Louth, Ireland</nlm:aff></affiliation></author><author><name sortKey="Naclerio, R" sort="Naclerio, R" uniqKey="Naclerio R" first="R." last="Naclerio">R. Naclerio</name><affiliation><nlm:aff id="Aff40">Section of Otolaryngology-Head and Neck Surgery, The University of Chicago Medical Center and The Pritzker School of Medicine, The University of Chicago, Chicago, IL USA</nlm:aff></affiliation></author><author><name sortKey="O Ehir, R E" sort="O Ehir, R E" uniqKey="O Ehir R" first="R. E." last="O Ehir">R. E. O Ehir</name><affiliation><nlm:aff id="Aff41">Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff42">Department of Immunology, Monash University, Melbourne, VIC Australia</nlm:aff></affiliation></author><author><name sortKey="Papadopoulos, N G" sort="Papadopoulos, N G" uniqKey="Papadopoulos N" first="N. G." last="Papadopoulos">N. G. Papadopoulos</name><affiliation><nlm:aff id="Aff43">Center for Pediatrics and Child Health, Institute of Human Development, Royal Manchester Children’s Hospital, University of Manchester, Manchester, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff44">Allergy Department, 2nd Pediatric Clinic, Athens General Children’s Hospital “P&A Kyriakou”, University of Athens, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Pawankar, R" sort="Pawankar, R" uniqKey="Pawankar R" first="R." last="Pawankar">R. Pawankar</name><affiliation><nlm:aff id="Aff45">Department of Pediatrics, Nippon Medical School, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Potter, P" sort="Potter, P" uniqKey="Potter P" first="P." last="Potter">P. Potter</name><affiliation><nlm:aff id="Aff46">Allergy Diagnostic and Clinical Research Unit, University of Cape Town Lung Institute, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Ryan, D" sort="Ryan, D" uniqKey="Ryan D" first="D." last="Ryan">D. Ryan</name><affiliation><nlm:aff id="Aff47">Woodbrook Medical Centre, Loughborough, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff48">Allergy and Respiratory Research Group, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Samolinski, B" sort="Samolinski, B" uniqKey="Samolinski B" first="B." last="Samolinski">B. Samolinski</name><affiliation><nlm:aff id="Aff49">Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Schunemann, H J" sort="Schunemann, H J" uniqKey="Schunemann H" first="H. J." last="Schunemann">H. J. Schunemann</name><affiliation><nlm:aff id="Aff50">Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada</nlm:aff></affiliation></author><author><name sortKey="Sheikh, A" sort="Sheikh, A" uniqKey="Sheikh A" first="A." last="Sheikh">A. Sheikh</name><affiliation><nlm:aff id="Aff51">Allergy and Respiratory Research Group, Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Simons, F E R" sort="Simons, F E R" uniqKey="Simons F" first="F. E. R." last="Simons">F. E. R. Simons</name><affiliation><nlm:aff id="Aff52">Department of Pediatrics and Child Health, Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, MB Canada</nlm:aff></affiliation></author><author><name sortKey="Stellato, C" sort="Stellato, C" uniqKey="Stellato C" first="C." last="Stellato">C. Stellato</name><affiliation><nlm:aff id="Aff53">Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy</nlm:aff></affiliation></author><author><name sortKey="Todo Bom, A" sort="Todo Bom, A" uniqKey="Todo Bom A" first="A." last="Todo-Bom">A. Todo-Bom</name><affiliation><nlm:aff id="Aff54">Centre of Pneumology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal</nlm:aff></affiliation></author><author><name sortKey="Tomazic, P V" sort="Tomazic, P V" uniqKey="Tomazic P" first="P. V." last="Tomazic">P. V. Tomazic</name><affiliation><nlm:aff id="Aff55">Department of ENT, Medical University of Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Valiulis, A" sort="Valiulis, A" uniqKey="Valiulis A" first="A." last="Valiulis">A. Valiulis</name><affiliation><nlm:aff id="Aff56">Clinic of Children’s Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania</nlm:aff></affiliation><affiliation><nlm:aff id="Aff57">Public Health Institute, Vilnius University, Vilnius, Lithuania</nlm:aff></affiliation><affiliation><nlm:aff id="Aff58">European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Valovirta, E" sort="Valovirta, E" uniqKey="Valovirta E" first="E." last="Valovirta">E. Valovirta</name><affiliation><nlm:aff id="Aff59">Department of Lung Diseases and Clinical Allergology, University of Turku, Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff60">Allergy Clinic, Terveystalo, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Ventura, M T" sort="Ventura, M T" uniqKey="Ventura M" first="M. T." last="Ventura">M. T. Ventura</name><affiliation><nlm:aff id="Aff61">Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy</nlm:aff></affiliation></author><author><name sortKey="Wickman, M" sort="Wickman, M" uniqKey="Wickman M" first="M." last="Wickman">M. Wickman</name><affiliation><nlm:aff id="Aff62">Sachs’ Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="Aff63">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Young, I" sort="Young, I" uniqKey="Young I" first="I." last="Young">I. Young</name><affiliation><nlm:aff id="Aff64">Queen’s University, Belfast, Northern Ireland, UK</nlm:aff></affiliation></author><author><name sortKey="Yorgancioglu, A" sort="Yorgancioglu, A" uniqKey="Yorgancioglu A" first="A." last="Yorgancioglu">A. Yorgancioglu</name><affiliation><nlm:aff id="Aff65">Department of Pulmonology, Celal Bayar University, Manisa, Turkey</nlm:aff></affiliation></author><author><name sortKey="Zuberbier, T" sort="Zuberbier, T" uniqKey="Zuberbier T" first="T." last="Zuberbier">T. Zuberbier</name><affiliation><nlm:aff id="Aff7">Allergy-Centre-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff8">Global Allergy and Asthma European Network (GA²LEN), Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Aberer, W" sort="Aberer, W" uniqKey="Aberer W" first="W." last="Aberer">W. Aberer</name><affiliation><nlm:aff id="Aff66">Department of Dermatology, Medical University of Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Akdis, C A" sort="Akdis, C A" uniqKey="Akdis C" first="C. A." last="Akdis">C. A. Akdis</name><affiliation><nlm:aff id="Aff67">Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Akdis, M" sort="Akdis, M" uniqKey="Akdis M" first="M." last="Akdis">M. Akdis</name><affiliation><nlm:aff id="Aff67">Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Annesi Maesano, I" sort="Annesi Maesano, I" uniqKey="Annesi Maesano I" first="I." last="Annesi-Maesano">I. Annesi-Maesano</name><affiliation><nlm:aff id="Aff21">EPAR U707 INSERM, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff22">EPAR UMR-S UPMC, Paris VI, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Ankri, J" sort="Ankri, J" uniqKey="Ankri J" first="J." last="Ankri">J. Ankri</name><affiliation><nlm:aff id="Aff3">INSERM, U1168, Ageing and Chronic Diseases Epidemiological and Public Health Approaches, 94800 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Ansotegui, I J" sort="Ansotegui, I J" uniqKey="Ansotegui I" first="I. J." last="Ansotegui">I. J. Ansotegui</name><affiliation><nlm:aff id="Aff68">Department of Allergy and Immunology, Hospital Quirón Bizkaia, Erandio, Spain</nlm:aff></affiliation></author><author><name sortKey="Anto, J M" sort="Anto, J M" uniqKey="Anto J" first="J. M." last="Anto">J. M. Anto</name><affiliation><nlm:aff id="Aff69">Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff70">IMIM (Hospital del Mar Research Institute), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff71">CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff72">Universitat Pompeu Fabra (UPF), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Arnavielhe, S" sort="Arnavielhe, S" uniqKey="Arnavielhe S" first="S." last="Arnavielhe">S. Arnavielhe</name><affiliation><nlm:aff id="Aff73">Kyomed, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Asarnoj, A" sort="Asarnoj, A" uniqKey="Asarnoj A" first="A." last="Asarnoj">A. Asarnoj</name><affiliation><nlm:aff id="Aff74">Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="Aff75">Department of Pediatric Pulmonology and Allergy, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Arshad, H" sort="Arshad, H" uniqKey="Arshad H" first="H." last="Arshad">H. Arshad</name><affiliation><nlm:aff id="Aff76">David Hide Asthma and Allergy Research Centre, Isle of Wight, UK</nlm:aff></affiliation></author><author><name sortKey="Avolio, F" sort="Avolio, F" uniqKey="Avolio F" first="F." last="Avolio">F. Avolio</name><affiliation><nlm:aff id="Aff77">Regionie Puglia, Bari, Italy</nlm:aff></affiliation></author><author><name sortKey="Baiardini, I" sort="Baiardini, I" uniqKey="Baiardini I" first="I." last="Baiardini">I. Baiardini</name><affiliation><nlm:aff id="Aff15">Asthma and Allergy Clinic, Humanitas University, Rozzano, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Barbara, C" sort="Barbara, C" uniqKey="Barbara C" first="C." last="Barbara">C. Barbara</name><affiliation><nlm:aff id="Aff78">Faculdade de Medicina de Lisboa, Portuguese National Programme for Respiratory Diseases (PNDR), Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Barbagallo, M" sort="Barbagallo, M" uniqKey="Barbagallo M" first="M." last="Barbagallo">M. Barbagallo</name><affiliation><nlm:aff id="Aff79">Geriatric Unit, Department of Internal Medicine (DIBIMIS), University of Palermo, Palermo, Italy</nlm:aff></affiliation></author><author><name sortKey="Bateman, E D" sort="Bateman, E D" uniqKey="Bateman E" first="E. D." last="Bateman">E. D. Bateman</name><affiliation><nlm:aff id="Aff80">Department of Medicine, University of Cape Town, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Beghe, B" sort="Beghe, B" uniqKey="Beghe B" first="B." last="Beghé">B. Beghé</name><affiliation><nlm:aff id="Aff81">Section of Respiratory Disease, Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy</nlm:aff></affiliation></author><author><name sortKey="Bel, E H" sort="Bel, E H" uniqKey="Bel E" first="E. H." last="Bel">E. H. Bel</name><affiliation><nlm:aff id="Aff82">Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bennoor, K S" sort="Bennoor, K S" uniqKey="Bennoor K" first="K. S." last="Bennoor">K. S. Bennoor</name><affiliation><nlm:aff id="Aff83">Department of Respiratory Medicine, National Institute of Diseases of the Chest and Hospital, Dhaka, Bangladesh</nlm:aff></affiliation></author><author><name sortKey="Benson, M" sort="Benson, M" uniqKey="Benson M" first="M." last="Benson">M. Benson</name><affiliation><nlm:aff id="Aff84">Centre for Individualized Medicine, Department of Pediatrics, Faculty of Medicine, Linköping University, 58185 Linköping, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bialoszewski, A Z" sort="Bialoszewski, A Z" uniqKey="Bialoszewski A" first="A. Z." last="Białoszewski">A. Z. Białoszewski</name><affiliation><nlm:aff id="Aff49">Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Bieber, T" sort="Bieber, T" uniqKey="Bieber T" first="T." last="Bieber">T. Bieber</name><affiliation><nlm:aff id="Aff85">Department of Dermatology and Allergy, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Bjermer, L" sort="Bjermer, L" uniqKey="Bjermer L" first="L." last="Bjermer">L. Bjermer</name><affiliation><nlm:aff id="Aff86">Department of Respiratory Medicine and Allergology, University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Blain, H" sort="Blain, H" uniqKey="Blain H" first="H." last="Blain">H. Blain</name><affiliation><nlm:aff id="Aff87">Department of Geriatrics, Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff88">EA 2991, Euromov, University Montpellier, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Blasi, F" sort="Blasi, F" uniqKey="Blasi F" first="F." last="Blasi">F. Blasi</name><affiliation><nlm:aff id="Aff89">Department of Pathophysiology and Transplantation, IRCCS Fondazione Ca’Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Boner, A L" sort="Boner, A L" uniqKey="Boner A" first="A. L." last="Boner">A. L. Boner</name><affiliation><nlm:aff id="Aff90">Pediatric Department, University of Verona Hospital, Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Bonini, M" sort="Bonini, M" uniqKey="Bonini M" first="M." last="Bonini">M. Bonini</name><affiliation><nlm:aff id="Aff91">Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Bonini, S" sort="Bonini, S" uniqKey="Bonini S" first="S." last="Bonini">S. Bonini</name><affiliation><nlm:aff id="Aff92">Second University of Naples and Institute of Translational Medicine, Italian National Research Council, Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Bosse, I" sort="Bosse, I" uniqKey="Bosse I" first="I." last="Bosse">I. Bosse</name><affiliation><nlm:aff id="Aff93">La Rochelle, France</nlm:aff></affiliation></author><author><name sortKey="Bouchard, J" sort="Bouchard, J" uniqKey="Bouchard J" first="J." last="Bouchard">J. Bouchard</name><affiliation><nlm:aff id="Aff94">Montreal, QC Canada</nlm:aff></affiliation></author><author><name sortKey="Boulet, L P" sort="Boulet, L P" uniqKey="Boulet L" first="L. P." last="Boulet">L. P. Boulet</name><affiliation><nlm:aff id="Aff95">Quebec Heart and Lung Institute, Laval University, Quebec City, QC Canada</nlm:aff></affiliation></author><author><name sortKey="Bourret, R" sort="Bourret, R" uniqKey="Bourret R" first="R." last="Bourret">R. Bourret</name><affiliation><nlm:aff id="Aff1">Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Bousquet, P J" sort="Bousquet, P J" uniqKey="Bousquet P" first="P. J." last="Bousquet">P. J. Bousquet</name><affiliation><nlm:aff id="Aff21">EPAR U707 INSERM, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Braido, F" sort="Braido, F" uniqKey="Braido F" first="F." last="Braido">F. Braido</name><affiliation><nlm:aff id="Aff15">Asthma and Allergy Clinic, Humanitas University, Rozzano, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Briggs, A H" sort="Briggs, A H" uniqKey="Briggs A" first="A. H." last="Briggs">A. H. Briggs</name><affiliation><nlm:aff id="Aff96">Health Economics and Health Technology Assessment, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Brightling, C E" sort="Brightling, C E" uniqKey="Brightling C" first="C. E." last="Brightling">C. E. Brightling</name><affiliation><nlm:aff id="Aff97">Institute of Lung Health, Respiratory Biomedical Unit, University Hospitals of Leicester NHS Trust, Leicestershire, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff98">Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK</nlm:aff></affiliation></author><author><name sortKey="Brozek, J" sort="Brozek, J" uniqKey="Brozek J" first="J." last="Brozek">J. Brozek</name><affiliation><nlm:aff id="Aff50">Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada</nlm:aff></affiliation></author><author><name sortKey="Buhl, R" sort="Buhl, R" uniqKey="Buhl R" first="R." last="Buhl">R. Buhl</name><affiliation><nlm:aff id="Aff99">Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany</nlm:aff></affiliation></author><author><name sortKey="Bunu, C" sort="Bunu, C" uniqKey="Bunu C" first="C." last="Bunu">C. Bunu</name><affiliation><nlm:aff id="Aff100">University of Medicine and Pharmacy Victor Babes, Timisoara, Romania</nlm:aff></affiliation></author><author><name sortKey="Burte, E" sort="Burte, E" uniqKey="Burte E" first="E." last="Burte">E. Burte</name><affiliation><nlm:aff id="Aff3">INSERM, U1168, Ageing and Chronic Diseases Epidemiological and Public Health Approaches, 94800 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Bush, A" sort="Bush, A" uniqKey="Bush A" first="A." last="Bush">A. Bush</name><affiliation><nlm:aff id="Aff101">Royal Brompton Hospital NHS, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Caballero Fonseca, F" sort="Caballero Fonseca, F" uniqKey="Caballero Fonseca F" first="F." last="Caballero-Fonseca">F. Caballero-Fonseca</name><affiliation><nlm:aff id="Aff102">Centro Medico Docente La Trinidad, Caracas, Venezuela</nlm:aff></affiliation></author><author><name sortKey="Calderon, M A" sort="Calderon, M A" uniqKey="Calderon M" first="M. A." last="Calderon">M. A. Calderon</name><affiliation><nlm:aff id="Aff101">Royal Brompton Hospital NHS, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff103">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Camuzat, T" sort="Camuzat, T" uniqKey="Camuzat T" first="T." last="Camuzat">T. Camuzat</name><affiliation><nlm:aff id="Aff104">Montpellier, Région Languedoc Roussillon France</nlm:aff></affiliation></author><author><name sortKey="Cardona, V" sort="Cardona, V" uniqKey="Cardona V" first="V." last="Cardona">V. Cardona</name><affiliation><nlm:aff id="Aff105">S. Allergologia, S. Medicina Interna, Hospital Vall d’Hebron, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Carreiro Martins, P" sort="Carreiro Martins, P" uniqKey="Carreiro Martins P" first="P." last="Carreiro-Martins">P. Carreiro-Martins</name><affiliation><nlm:aff id="Aff106">CEDOC, Respiratory Research Group, Nova Medical School, Campo dos Martires da Patria, Lisbon, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff107">Serviço de Imunoalergologia, Centro Hospitalar de Lisboa Central, EPE, Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Carriazo, A M" sort="Carriazo, A M" uniqKey="Carriazo A" first="A. M." last="Carriazo">A. M. Carriazo</name><affiliation><nlm:aff id="Aff108">Regional Ministry of Health of Andalusia, Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Carlsen, K H" sort="Carlsen, K H" uniqKey="Carlsen K" first="K. H." last="Carlsen">K. H. Carlsen</name><affiliation><nlm:aff id="Aff109">Department of Paediatrics, Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="Aff110">University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Carr, W" sort="Carr, W" uniqKey="Carr W" first="W." last="Carr">W. Carr</name><affiliation><nlm:aff id="Aff111">Allergy and Asthma Associates of Southern California, Mission Viejo, CA USA</nlm:aff></affiliation></author><author><name sortKey="Cepeda Sarabia, A M" sort="Cepeda Sarabia, A M" uniqKey="Cepeda Sarabia A" first="A. M." last="Cepeda Sarabia">A. M. Cepeda Sarabia</name><affiliation><nlm:aff id="Aff112">Allergy and Immunology Laboratory, Metropolitan University, Simon Bolivar University, Barranquilla, Colombia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff113">SLaai, Sociedad Latinoamericana de Allergia, Asma e Immunologia, Cartagena, Colombia</nlm:aff></affiliation></author><author><name sortKey="Cesari, M" sort="Cesari, M" uniqKey="Cesari M" first="M." last="Cesari">M. Cesari</name><affiliation><nlm:aff id="Aff114">Gérontopôle de Toulouse, 31059 Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Chatzi, L" sort="Chatzi, L" uniqKey="Chatzi L" first="L." last="Chatzi">L. Chatzi</name><affiliation><nlm:aff id="Aff115">Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete Greece</nlm:aff></affiliation></author><author><name sortKey="Chiron, R" sort="Chiron, R" uniqKey="Chiron R" first="R." last="Chiron">R. Chiron</name><affiliation><nlm:aff id="Aff13">Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Chivato, T" sort="Chivato, T" uniqKey="Chivato T" first="T." last="Chivato">T. Chivato</name><affiliation><nlm:aff id="Aff116">School of Medicine, University CEU San Pablo, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Chkhartishvili, E" sort="Chkhartishvili, E" uniqKey="Chkhartishvili E" first="E." last="Chkhartishvili">E. Chkhartishvili</name><affiliation><nlm:aff id="Aff117">Chachava Clinic, David Tvildiani Medical University-AIETI Medical School, Grigol Robakidze University, Tbilisi, Georgia</nlm:aff></affiliation></author><author><name sortKey="Chuchalin, A G" sort="Chuchalin, A G" uniqKey="Chuchalin A" first="A. G." last="Chuchalin">A. G. Chuchalin</name><affiliation><nlm:aff id="Aff118">Pulmonolory Research Institute FMBA, Moscow, Russia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff119">GARD Executive Committee, Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Chung, K F" sort="Chung, K F" uniqKey="Chung K" first="K. F." last="Chung">K. F. Chung</name><affiliation><nlm:aff id="Aff103">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Ciprandi, G" sort="Ciprandi, G" uniqKey="Ciprandi G" first="G." last="Ciprandi">G. Ciprandi</name><affiliation><nlm:aff id="Aff120">Medicine Department, IRCCS-Azienda Ospedaliera Universitaria San Martino, Genoa, Italy</nlm:aff></affiliation></author><author><name sortKey="De Sousa, J Correia" sort="De Sousa, J Correia" uniqKey="De Sousa J" first="J. Correia" last="De Sousa">J. Correia De Sousa</name><affiliation><nlm:aff id="Aff121">ICVS/3B’s-PT Government Associate Laboratory, Life and Health Sciences, Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal</nlm:aff></affiliation></author><author><name sortKey="Cox, L" sort="Cox, L" uniqKey="Cox L" first="L." last="Cox">L. Cox</name><affiliation><nlm:aff id="Aff122">Department of Medicine, Nova Southeastern University, Davie, FL USA</nlm:aff></affiliation></author><author><name sortKey="Crooks, G" sort="Crooks, G" uniqKey="Crooks G" first="G." last="Crooks">G. Crooks</name><affiliation><nlm:aff id="Aff123">EIP on AHA, European Innovation Partnership on Active and Healthy Ageing, Reference Site, Scottish Centre for Telehealth and Telecare, NHS 24, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Custovic, A" sort="Custovic, A" uniqKey="Custovic A" first="A." last="Custovic">A. Custovic</name><affiliation><nlm:aff id="Aff124">Department of Pediatric, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Dahlen, S E" sort="Dahlen, S E" uniqKey="Dahlen S" first="S. E." last="Dahlen">S. E. Dahlen</name><affiliation><nlm:aff id="Aff125">The Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darsow, U" sort="Darsow, U" uniqKey="Darsow U" first="U." last="Darsow">U. Darsow</name><affiliation><nlm:aff id="Aff126">Department of Dermatology and Allergy, Technische Universität München, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff127">ZAUM-Center for Allergy and Environment, Helmholtz Center Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Dedeu, T" sort="Dedeu, T" uniqKey="Dedeu T" first="T." last="Dedeu">T. Dedeu</name><affiliation><nlm:aff id="Aff128">AQuAS, Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff129">EUREGHA, European Regional and Local Health Association, Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Deleanu, D" sort="Deleanu, D" uniqKey="Deleanu D" first="D." last="Deleanu">D. Deleanu</name><affiliation><nlm:aff id="Aff130">Allergology and Immunology Discipline, “Luliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania</nlm:aff></affiliation></author><author><name sortKey="Denburg, J A" sort="Denburg, J A" uniqKey="Denburg J" first="J. A." last="Denburg">J. A. Denburg</name><affiliation><nlm:aff id="Aff131">Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON Canada</nlm:aff></affiliation></author><author><name sortKey="De Vries, G" sort="De Vries, G" uniqKey="De Vries G" first="G." last="De Vries">G. De Vries</name><affiliation><nlm:aff id="Aff132">Peercode DV, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Didier, A" sort="Didier, A" uniqKey="Didier A" first="A." last="Didier">A. Didier</name><affiliation><nlm:aff id="Aff133">Respiratory Diseases Department, Rangueil-Larrey Hospital, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Dinh Xuan, A T" sort="Dinh Xuan, A T" uniqKey="Dinh Xuan A" first="A. T." last="Dinh-Xuan">A. T. Dinh-Xuan</name><affiliation><nlm:aff id="Aff134">Service de Physiologie Respiratoire, Hôpital Cochin, Université Paris-Descartes, Assistance Publique-Hôpitaux de Paris, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Dokic, D" sort="Dokic, D" uniqKey="Dokic D" first="D." last="Dokic">D. Dokic</name><affiliation><nlm:aff id="Aff135">University Clinic of Pulmology and Allergy, Medical Faculty, Ss Cyril and Methodius University, Skopje, Republic of Macedonia</nlm:aff></affiliation></author><author><name sortKey="Douagui, H" sort="Douagui, H" uniqKey="Douagui H" first="H." last="Douagui">H. Douagui</name><affiliation><nlm:aff id="Aff136">Service de Pneumo-Allergologie, Centre Hospitalo-Universitaire de Béni-Messous, Algers, Algeria</nlm:aff></affiliation></author><author><name sortKey="Dray, G" sort="Dray, G" uniqKey="Dray G" first="G." last="Dray">G. Dray</name><affiliation><nlm:aff id="Aff137">Ecole des Mines, Alès, France</nlm:aff></affiliation></author><author><name sortKey="Dubakiene, R" sort="Dubakiene, R" uniqKey="Dubakiene R" first="R." last="Dubakiene">R. Dubakiene</name><affiliation><nlm:aff id="Aff138">Medical Faculty, Vilnius University, Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Durham, S R" sort="Durham, S R" uniqKey="Durham S" first="S. R." last="Durham">S. R. Durham</name><affiliation><nlm:aff id="Aff139">Allergy and Clinical Immunology Section, National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Du Toit, G" sort="Du Toit, G" uniqKey="Du Toit G" first="G." last="Du Toit">G. Du Toit</name><affiliation><nlm:aff id="Aff140">Guy’s and St Thomas’ NHS Trust, Kings College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Dykewicz, M S" sort="Dykewicz, M S" uniqKey="Dykewicz M" first="M. S." last="Dykewicz">M. S. Dykewicz</name><affiliation><nlm:aff id="Aff141">Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, MO USA</nlm:aff></affiliation></author><author><name sortKey="Eklund, P" sort="Eklund, P" uniqKey="Eklund P" first="P." last="Eklund">P. Eklund</name><affiliation><nlm:aff id="Aff142">Computing Science Department, Umeå University, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="Aff143">Four Computing Oy, Halikko, Finland</nlm:aff></affiliation></author><author><name sortKey="El Gamal, Y" sort="El Gamal, Y" uniqKey="El Gamal Y" first="Y." last="El-Gamal">Y. El-Gamal</name><affiliation><nlm:aff id="Aff144">Pediatric Allergy and Immunology Unit, Ain Shams University, Cairo, Egypt</nlm:aff></affiliation></author><author><name sortKey="Ellers, E" sort="Ellers, E" uniqKey="Ellers E" first="E." last="Ellers">E. Ellers</name><affiliation><nlm:aff id="Aff10">Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Emuzyte, R" sort="Emuzyte, R" uniqKey="Emuzyte R" first="R." last="Emuzyte">R. Emuzyte</name><affiliation><nlm:aff id="Aff56">Clinic of Children’s Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania</nlm:aff></affiliation><affiliation><nlm:aff id="Aff57">Public Health Institute, Vilnius University, Vilnius, Lithuania</nlm:aff></affiliation><affiliation><nlm:aff id="Aff58">European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Farrell, J" sort="Farrell, J" uniqKey="Farrell J" first="J." last="Farrell">J. Farrell</name><affiliation><nlm:aff id="Aff145">Department of Health, Social Services and Public Safety, Belfast, Northern Ireland, UK</nlm:aff></affiliation></author><author><name sortKey="Fink Wagner, A" sort="Fink Wagner, A" uniqKey="Fink Wagner A" first="A." last="Fink Wagner">A. Fink Wagner</name><affiliation><nlm:aff id="Aff146">Global Allergy and Asthma Platform GAAPP, Altgasse 8-10, 1130 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Fiocchi, A" sort="Fiocchi, A" uniqKey="Fiocchi A" first="A." last="Fiocchi">A. Fiocchi</name><affiliation><nlm:aff id="Aff147">Division of Allergy, Department of Pediatric Medicine, The Bambino Gesù Children’s Research Hospital Holy See, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Fletcher, M" sort="Fletcher, M" uniqKey="Fletcher M" first="M." last="Fletcher">M. Fletcher</name><affiliation><nlm:aff id="Aff148">Education for Health, Warwick, UK</nlm:aff></affiliation></author><author><name sortKey="Forastiere, F" sort="Forastiere, F" uniqKey="Forastiere F" first="F." last="Forastiere">F. Forastiere</name><affiliation><nlm:aff id="Aff149">Department of Epidemiology, Regional Health Service Lazio Region, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Gaga, M" sort="Gaga, M" uniqKey="Gaga M" first="M." last="Gaga">M. Gaga</name><affiliation><nlm:aff id="Aff150">Athens Chest Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Gamkrelidze, A" sort="Gamkrelidze, A" uniqKey="Gamkrelidze A" first="A." last="Gamkrelidze">A. Gamkrelidze</name><affiliation><nlm:aff id="Aff151">National Center for Disease Control and Public Health of Georgia, Tbilisi, Georgia</nlm:aff></affiliation></author><author><name sortKey="Gemicio Lu, B" sort="Gemicio Lu, B" uniqKey="Gemicio Lu B" first="B." last="Gemicio Lu">B. Gemicio Lu</name><affiliation><nlm:aff id="Aff152">Department of Pulmonary Diseases, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey</nlm:aff></affiliation></author><author><name sortKey="Gereda, J E" sort="Gereda, J E" uniqKey="Gereda J" first="J. E." last="Gereda">J. E. Gereda</name><affiliation><nlm:aff id="Aff153">Allergy and Immunology Division, Clinica Ricardo Palma, Lima, Peru</nlm:aff></affiliation></author><author><name sortKey="Van Wick, R Gerth" sort="Van Wick, R Gerth" uniqKey="Van Wick R" first="R. Gerth" last="Van Wick">R. Gerth Van Wick</name><affiliation><nlm:aff id="Aff154">Section of Allergology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Diaz, S" sort="Gonzalez Diaz, S" uniqKey="Gonzalez Diaz S" first="S." last="González Diaz">S. González Diaz</name><affiliation><nlm:aff id="Aff155">Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Mexico</nlm:aff></affiliation></author><author><name sortKey="Grisle, I" sort="Grisle, I" uniqKey="Grisle I" first="I." last="Grisle">I. Grisle</name><affiliation><nlm:aff id="Aff156">Center of Tuberculosis and Lung Diseases, Latvian Association of Allergists, Riga, Latvia</nlm:aff></affiliation></author><author><name sortKey="Grouse, L" sort="Grouse, L" uniqKey="Grouse L" first="L." last="Grouse">L. Grouse</name><affiliation><nlm:aff id="Aff157">Faculty of the Department of Neurology, University of Washington School of Medicine, Seattle, WA USA</nlm:aff></affiliation></author><author><name sortKey="Gutter, Z" sort="Gutter, Z" uniqKey="Gutter Z" first="Z." last="Gutter">Z. Gutter</name><affiliation><nlm:aff id="Aff158">National eHealth Centre, University Hospital Olomouc, Olomouc, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Guzman, M A" sort="Guzman, M A" uniqKey="Guzman M" first="M. A." last="Guzmán">M. A. Guzmán</name><affiliation><nlm:aff id="Aff159">Immunology and Allergy Division Clinical Hospital, University of Chile, Santiago, Chile</nlm:aff></affiliation></author><author><name sortKey="Hellquist Dahl, B" sort="Hellquist Dahl, B" uniqKey="Hellquist Dahl B" first="B." last="Hellquist-Dahl">B. Hellquist-Dahl</name><affiliation><nlm:aff id="Aff160">Department of Respiratory Diseases, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Heinrich, J" sort="Heinrich, J" uniqKey="Heinrich J" first="J." last="Heinrich">J. Heinrich</name><affiliation><nlm:aff id="Aff161">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Horak, F" sort="Horak, F" uniqKey="Horak F" first="F." last="Horak">F. Horak</name><affiliation><nlm:aff id="Aff162">Vienna Challenge Chamber, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Hourihane, J O B" sort="Hourihane, J O B" uniqKey="Hourihane J" first="J. O B." last="Hourihane">J. O B. Hourihane</name><affiliation><nlm:aff id="Aff163">Department of Paediatrics and Child Health, University College Cork, Cork, Ireland</nlm:aff></affiliation></author><author><name sortKey="Humbert, M" sort="Humbert, M" uniqKey="Humbert M" first="M." last="Humbert">M. Humbert</name><affiliation><nlm:aff id="Aff164">Université Paris-Sud, Le Kremlin Bicêtre, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff165">Service de Pneumologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff166">Inserm UMR_S999, Le Kremlin Bicêtre, France</nlm:aff></affiliation></author><author><name sortKey="Hyland, M" sort="Hyland, M" uniqKey="Hyland M" first="M." last="Hyland">M. Hyland</name><affiliation><nlm:aff id="Aff167">School of Psychology, Plymouth University, Plymouth, UK</nlm:aff></affiliation></author><author><name sortKey="Iaccarino, G" sort="Iaccarino, G" uniqKey="Iaccarino G" first="G." last="Iaccarino">G. Iaccarino</name><affiliation><nlm:aff id="Aff168">Department of Medicine and Surgery, University of Salerno, Baronissi, Italy</nlm:aff></affiliation></author><author><name sortKey="Jares, E J" sort="Jares, E J" uniqKey="Jares E" first="E. J." last="Jares">E. J. Jares</name><affiliation><nlm:aff id="Aff169">Libra Foundation, Buenos Aires, Argentina</nlm:aff></affiliation></author><author><name sortKey="Jeandel, C" sort="Jeandel, C" uniqKey="Jeandel C" first="C." last="Jeandel">C. Jeandel</name><affiliation><nlm:aff id="Aff2">MACVIA-France, Contre les MAladies Chroniques pour un VIeillissement Actif en France, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff87">Department of Geriatrics, Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Johnston, S L" sort="Johnston, S L" uniqKey="Johnston S" first="S. L." last="Johnston">S. L. Johnston</name><affiliation><nlm:aff id="Aff170">Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff171">MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK</nlm:aff></affiliation></author><author><name sortKey="Joos, G" sort="Joos, G" uniqKey="Joos G" first="G." last="Joos">G. Joos</name><affiliation><nlm:aff id="Aff172">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Jonquet, O" sort="Jonquet, O" uniqKey="Jonquet O" first="O." last="Jonquet">O. Jonquet</name><affiliation><nlm:aff id="Aff173">Medical Commission, Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Jung, K S" sort="Jung, K S" uniqKey="Jung K" first="K. S." last="Jung">K. S. Jung</name><affiliation><nlm:aff id="Aff174">Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Gyeonggi-do South Korea</nlm:aff></affiliation></author><author><name sortKey="Jutel, M" sort="Jutel, M" uniqKey="Jutel M" first="M." last="Jutel">M. Jutel</name><affiliation><nlm:aff id="Aff175">Department of Clinical Immunology, Wrocław Medical University, Wrocław, Poland</nlm:aff></affiliation></author><author><name sortKey="Kaidashev, I" sort="Kaidashev, I" uniqKey="Kaidashev I" first="I." last="Kaidashev">I. Kaidashev</name><affiliation><nlm:aff id="Aff176">Ukrainian Medical Stomatological Academy, Poltava, Ukraine</nlm:aff></affiliation></author><author><name sortKey="Khaitov, M" sort="Khaitov, M" uniqKey="Khaitov M" first="M." last="Khaitov">M. Khaitov</name><affiliation><nlm:aff id="Aff177">Laboratory of Molecular Immunology, National Research Center, Institute of Immunology, Federal Medicobiological Agency, Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Kalayci, O" sort="Kalayci, O" uniqKey="Kalayci O" first="O." last="Kalayci">O. Kalayci</name><affiliation><nlm:aff id="Aff178">Pediatric Allergy and Asthma Unit, School of Medicine, Hacettepe University, Ankara, Turkey</nlm:aff></affiliation></author><author><name sortKey="Kalyoncu, A F" sort="Kalyoncu, A F" uniqKey="Kalyoncu A" first="A. F." last="Kalyoncu">A. F. Kalyoncu</name><affiliation><nlm:aff id="Aff179">Immunology and Allergy Division, Department of Chest Diseases, School of Medicine, Hacettepe University, Ankara, Turkey</nlm:aff></affiliation></author><author><name sortKey="Kardas, P" sort="Kardas, P" uniqKey="Kardas P" first="P." last="Kardas">P. Kardas</name><affiliation><nlm:aff id="Aff180">First Department of Family Medicine, Medical University of Lodz, Lodz, Poland</nlm:aff></affiliation></author><author><name sortKey="Keith, P K" sort="Keith, P K" uniqKey="Keith P" first="P. K." last="Keith">P. K. Keith</name><affiliation><nlm:aff id="Aff181">Department of Medicine, McMaster University, Health Sciences Centre 3V47, 1280 Main Street West, Hamilton, ON Canada</nlm:aff></affiliation></author><author><name sortKey="Kerkhof, M" sort="Kerkhof, M" uniqKey="Kerkhof M" first="M." last="Kerkhof">M. Kerkhof</name><affiliation><nlm:aff id="Aff182">Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kerstjens, H A M" sort="Kerstjens, H A M" uniqKey="Kerstjens H" first="H. A. M." last="Kerstjens">H. A. M. Kerstjens</name><affiliation><nlm:aff id="Aff182">Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Khaltaev, N" sort="Khaltaev, N" uniqKey="Khaltaev N" first="N." last="Khaltaev">N. Khaltaev</name><affiliation><nlm:aff id="Aff183">GARD, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M." last="Kogevinas">M. Kogevinas</name><affiliation><nlm:aff id="Aff69">Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff70">IMIM (Hospital del Mar Research Institute), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff71">CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff72">Universitat Pompeu Fabra (UPF), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Kolek, V" sort="Kolek, V" uniqKey="Kolek V" first="V." last="Kolek">V. Kolek</name><affiliation><nlm:aff id="Aff184">Department of Respiratory Medicine, Faculty of Medicine and Dentistry, University Hospital Olomouc, Olomouc, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Koppelman, G H" sort="Koppelman, G H" uniqKey="Koppelman G" first="G. H." last="Koppelman">G. H. Koppelman</name><affiliation><nlm:aff id="Aff185">Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children’s Hospital, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kowalski, M L" sort="Kowalski, M L" uniqKey="Kowalski M" first="M. L." last="Kowalski">M. L. Kowalski</name><affiliation><nlm:aff id="Aff186">Department of Immunology, Rheumatology and Allergy and HARC, Medical University of Lodz, Lodz, Poland</nlm:aff></affiliation></author><author><name sortKey="Kuitunen, M" sort="Kuitunen, M" uniqKey="Kuitunen M" first="M." last="Kuitunen">M. Kuitunen</name><affiliation><nlm:aff id="Aff187">Children’s Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kull, I" sort="Kull, I" uniqKey="Kull I" first="I." last="Kull">I. Kull</name><affiliation><nlm:aff id="Aff62">Sachs’ Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="Aff63">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kvedariene, V" sort="Kvedariene, V" uniqKey="Kvedariene V" first="V." last="Kvedariene">V. Kvedariene</name><affiliation><nlm:aff id="Aff188">Clinic of Infectious, Chest Diseases, Dermatology and Allergology, Vilnius University, Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Lambrecht, B" sort="Lambrecht, B" uniqKey="Lambrecht B" first="B." last="Lambrecht">B. Lambrecht</name><affiliation><nlm:aff id="Aff189">VIB Inflammation Research Center, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Lau, S" sort="Lau, S" uniqKey="Lau S" first="S." last="Lau">S. Lau</name><affiliation><nlm:aff id="Aff190">Department for Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Laune, D" sort="Laune, D" uniqKey="Laune D" first="D." last="Laune">D. Laune</name><affiliation><nlm:aff id="Aff73">Kyomed, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Le, L T T" sort="Le, L T T" uniqKey="Le L" first="L. T. T." last="Le">L. T. T. Le</name><affiliation><nlm:aff id="Aff191">University of Medicine and Pharmacy, Hochiminh City, Vietnam</nlm:aff></affiliation></author><author><name sortKey="Lieberman, P" sort="Lieberman, P" uniqKey="Lieberman P" first="P." last="Lieberman">P. Lieberman</name><affiliation><nlm:aff id="Aff192">Divisions of Allergy and Immunology, Department of Internal Medicine and Pediatrics, University of Tennessee College of Medicine, Germantown, TN USA</nlm:aff></affiliation></author><author><name sortKey="Lipworth, B" sort="Lipworth, B" uniqKey="Lipworth B" first="B." last="Lipworth">B. Lipworth</name><affiliation><nlm:aff id="Aff193">Scottish Centre for Respiratory Research, Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, UK</nlm:aff></affiliation></author><author><name sortKey="Li, J" sort="Li, J" uniqKey="Li J" first="J." last="Li">J. Li</name><affiliation><nlm:aff id="Aff194">State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Lodrup Carlsen, K C" sort="Lodrup Carlsen, K C" uniqKey="Lodrup Carlsen K" first="K. C." last="Lodrup Carlsen">K. C. Lodrup Carlsen</name><affiliation><nlm:aff id="Aff109">Department of Paediatrics, Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="Aff195">Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Louis, R" sort="Louis, R" uniqKey="Louis R" first="R." last="Louis">R. Louis</name><affiliation><nlm:aff id="Aff196">Department of Pulmonary Medicine, CHU Sart-Tilman, Liege, Belgium</nlm:aff></affiliation></author><author><name sortKey="Lupinek, C" sort="Lupinek, C" uniqKey="Lupinek C" first="C." last="Lupinek">C. Lupinek</name><affiliation><nlm:aff id="Aff197">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Macnee, W" sort="Macnee, W" uniqKey="Macnee W" first="W." last="Macnee">W. Macnee</name><affiliation><nlm:aff id="Aff198">The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Magar, Y" sort="Magar, Y" uniqKey="Magar Y" first="Y." last="Magar">Y. Magar</name><affiliation><nlm:aff id="Aff199">Service de Pneumo-allergologie, Hôpital Saint-Joseph, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Magnan, A" sort="Magnan, A" uniqKey="Magnan A" first="A." last="Magnan">A. Magnan</name><affiliation><nlm:aff id="Aff200">Service de Pneumologie, UMR INSERM, UMR1087 and CNR 6291, l’institut du Thorax, University of Nantes, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Mahboub, B" sort="Mahboub, B" uniqKey="Mahboub B" first="B." last="Mahboub">B. Mahboub</name><affiliation><nlm:aff id="Aff201">Department of Pulmonary Medicine, Rashid Hospital, Dubai, UAE</nlm:aff></affiliation></author><author><name sortKey="Maier, D" sort="Maier, D" uniqKey="Maier D" first="D." last="Maier">D. Maier</name><affiliation><nlm:aff id="Aff202">Biomax Informatics AG, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Majer, I" sort="Majer, I" uniqKey="Majer I" first="I." last="Majer">I. Majer</name><affiliation><nlm:aff id="Aff203">Department of Respiratory Medicine, University of Bratislava, Bratislava, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Malva, J" sort="Malva, J" uniqKey="Malva J" first="J." last="Malva">J. Malva</name><affiliation><nlm:aff id="Aff204">Institute of Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff205">Ageing@Coimbra EIP-AHA Reference Site, Coimbra, Portugal</nlm:aff></affiliation></author><author><name sortKey="Manning, P" sort="Manning, P" uniqKey="Manning P" first="P." last="Manning">P. Manning</name><affiliation><nlm:aff id="Aff206">Department of Medicine (RCSI), Bon Secours Hospital, Glasnevin, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="De Manuel Keenoy, E" sort="De Manuel Keenoy, E" uniqKey="De Manuel Keenoy E" first="E." last="De Manuel Keenoy">E. De Manuel Keenoy</name><affiliation><nlm:aff id="Aff207">Kronikgune, Basque Region, Spain</nlm:aff></affiliation></author><author><name sortKey="Marshall, G D" sort="Marshall, G D" uniqKey="Marshall G" first="G. D." last="Marshall">G. D. Marshall</name><affiliation><nlm:aff id="Aff208">Laboratory of Behavioral Immunology Research, Division of Clinical Immunology and Allergy, The University of Mississippi Medical Center, Jackson, MS USA</nlm:aff></affiliation></author><author><name sortKey="Masjedi, M R" sort="Masjedi, M R" uniqKey="Masjedi M" first="M. R." last="Masjedi">M. R. Masjedi</name><affiliation><nlm:aff id="Aff209">Tobacco Control Research Centre, Iranian Anti Tobacco Association, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Mathieu Dupas, E" sort="Mathieu Dupas, E" uniqKey="Mathieu Dupas E" first="E." last="Mathieu-Dupas">E. Mathieu-Dupas</name><affiliation><nlm:aff id="Aff73">Kyomed, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Maurer, M" sort="Maurer, M" uniqKey="Maurer M" first="M." last="Maurer">M. Maurer</name><affiliation><nlm:aff id="Aff7">Allergy-Centre-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Mavale Manuel, S" sort="Mavale Manuel, S" uniqKey="Mavale Manuel S" first="S." last="Mavale-Manuel">S. Mavale-Manuel</name><affiliation><nlm:aff id="Aff210">Department of Paediatrics, Maputo Central Hospital, Maputo, Mozambique</nlm:aff></affiliation></author><author><name sortKey="Melen, E" sort="Melen, E" uniqKey="Melen E" first="E." last="Melén">E. Melén</name><affiliation><nlm:aff id="Aff62">Sachs’ Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="Aff63">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Melo Gomes, E" sort="Melo Gomes, E" uniqKey="Melo Gomes E" first="E." last="Melo-Gomes">E. Melo-Gomes</name><affiliation><nlm:aff id="Aff78">Faculdade de Medicina de Lisboa, Portuguese National Programme for Respiratory Diseases (PNDR), Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Meltzer, E O" sort="Meltzer, E O" uniqKey="Meltzer E" first="E. O." last="Meltzer">E. O. Meltzer</name><affiliation><nlm:aff id="Aff211">Allergy and Asthma Medical Group and Research Center, San Diego, CA USA</nlm:aff></affiliation></author><author><name sortKey="Mercier, J" sort="Mercier, J" uniqKey="Mercier J" first="J." last="Mercier">J. Mercier</name><affiliation><nlm:aff id="Aff212">Department of Physiology, CHRU, PhyMedExp, INSERM U1046, CNRS UMR 9214, University Montpellier, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Merk, H" sort="Merk, H" uniqKey="Merk H" first="H." last="Merk">H. Merk</name><affiliation><nlm:aff id="Aff213">Hautklinik - Klinik für Dermatologie & Allergologie, Universitätsklinikum der RWTH Aachen, Aachen, Germany</nlm:aff></affiliation></author><author><name sortKey="Miculinic, N" sort="Miculinic, N" uniqKey="Miculinic N" first="N." last="Miculinic">N. Miculinic</name><affiliation><nlm:aff id="Aff214">Croatian Pulmonary Society, Zagreb, Croatia</nlm:aff></affiliation></author><author><name sortKey="Mihaltan, F" sort="Mihaltan, F" uniqKey="Mihaltan F" first="F." last="Mihaltan">F. Mihaltan</name><affiliation><nlm:aff id="Aff215">National Institute of Pneumology M. Nasta, Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Milenkovic, B" sort="Milenkovic, B" uniqKey="Milenkovic B" first="B." last="Milenkovic">B. Milenkovic</name><affiliation><nlm:aff id="Aff216">Faculty of Medicine, University of Belgrade, Belgrade, Serbia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff217">Serbian Association for Asthma and COPD, Belgrade, Serbia</nlm:aff></affiliation></author><author><name sortKey="Millot Keurinck, J" sort="Millot Keurinck, J" uniqKey="Millot Keurinck J" first="J." last="Millot-Keurinck">J. Millot-Keurinck</name><affiliation><nlm:aff id="Aff218">Caisse d’assurance retraite et de la santé au travail du Languedoc-Roussillon (CARSAT-LR), Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Mohammad, Y" sort="Mohammad, Y" uniqKey="Mohammad Y" first="Y." last="Mohammad">Y. Mohammad</name><affiliation><nlm:aff id="Aff219">National Center for Research in Chronic Respiratory Diseases, Tishreen University School of Medicine, Latakia, Syria</nlm:aff></affiliation></author><author><name sortKey="Momas, I" sort="Momas, I" uniqKey="Momas I" first="I." last="Momas">I. Momas</name><affiliation><nlm:aff id="Aff220">Department of Public Health and Health Products, EA 4064, Paris Descartes University-Sorbonne Paris Cité, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff221">Paris Municipal Department of Social Action, Childhood, and Health, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mosges, R" sort="Mosges, R" uniqKey="Mosges R" first="R." last="Mösges">R. Mösges</name><affiliation><nlm:aff id="Aff222">Institute of Medical Statistics, Informatics and Epidemiology, Medical Faculty, University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Muraro, A" sort="Muraro, A" uniqKey="Muraro A" first="A." last="Muraro">A. Muraro</name><affiliation><nlm:aff id="Aff223">Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Namazova Baranova, L" sort="Namazova Baranova, L" uniqKey="Namazova Baranova L" first="L." last="Namazova-Baranova">L. Namazova-Baranova</name><affiliation><nlm:aff id="Aff224">Scientific Centre of Children’s Health Under the Russian Academy of Medical Sciences, Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Nadif, R" sort="Nadif, R" uniqKey="Nadif R" first="R." last="Nadif">R. Nadif</name><affiliation><nlm:aff id="Aff3">INSERM, U1168, Ageing and Chronic Diseases Epidemiological and Public Health Approaches, 94800 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Neffen, H" sort="Neffen, H" uniqKey="Neffen H" first="H." last="Neffen">H. Neffen</name><affiliation><nlm:aff id="Aff225">Hospital de Niños Orlando Alassia, Santa Fe, Argentina</nlm:aff></affiliation></author><author><name sortKey="Nekam, K" sort="Nekam, K" uniqKey="Nekam K" first="K." last="Nekam">K. Nekam</name><affiliation><nlm:aff id="Aff226">Hospital of the Hospitaller Brothers in Buda, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Nieto, A" sort="Nieto, A" uniqKey="Nieto A" first="A." last="Nieto">A. Nieto</name><affiliation><nlm:aff id="Aff227">Neumología y Alergología Infantil, Hospital La Fe, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Niggemann, B" sort="Niggemann, B" uniqKey="Niggemann B" first="B." last="Niggemann">B. Niggemann</name><affiliation><nlm:aff id="Aff190">Department for Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Nogueira Silva, L" sort="Nogueira Silva, L" uniqKey="Nogueira Silva L" first="L." last="Nogueira-Silva">L. Nogueira-Silva</name><affiliation><nlm:aff id="Aff24">Center for Research in Health Technologies and Information Systems - CINTESIS, Universidade do Porto, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff25">Allergy Unit, Instituto CUF Porto e Hospital CUF Porto, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff26">Health Information and Decision Sciences Department - CIDES, Faculdade de Medicina, Universidade do Porto, Rua Dr. Plácido da Costa, s/n, 4200-450 Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff228">Department of Internal Medicine, Centro Hospitalar Sao Joao, Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Nogues, M" sort="Nogues, M" uniqKey="Nogues M" first="M." last="Nogues">M. Nogues</name><affiliation><nlm:aff id="Aff2">MACVIA-France, Contre les MAladies Chroniques pour un VIeillissement Actif en France, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff218">Caisse d’assurance retraite et de la santé au travail du Languedoc-Roussillon (CARSAT-LR), Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Nyembue, T D" sort="Nyembue, T D" uniqKey="Nyembue T" first="T. D." last="Nyembue">T. D. Nyembue</name><affiliation><nlm:aff id="Aff229">ENT Department, University Hospital of Kinshasa, Kinshasa, Congo</nlm:aff></affiliation></author><author><name sortKey="Ohta, K" sort="Ohta, K" uniqKey="Ohta K" first="K." last="Ohta">K. Ohta</name><affiliation><nlm:aff id="Aff230">National Hospital Organization, Tokyo National Hospital, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Okamoto, Y" sort="Okamoto, Y" uniqKey="Okamoto Y" first="Y." last="Okamoto">Y. Okamoto</name><affiliation><nlm:aff id="Aff231">Department of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan</nlm:aff></affiliation></author><author><name sortKey="Okubo, K" sort="Okubo, K" uniqKey="Okubo K" first="K." last="Okubo">K. Okubo</name><affiliation><nlm:aff id="Aff232">Department of Otolaryngology, Nippon Medical School, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Olive Elias, M" sort="Olive Elias, M" uniqKey="Olive Elias M" first="M." last="Olive-Elias">M. Olive-Elias</name><affiliation><nlm:aff id="Aff1">Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff28">Institute of Health Policy and Management IBMG, Erasmus University, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="Aff29">Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ouedraogo, S" sort="Ouedraogo, S" uniqKey="Ouedraogo S" first="S." last="Ouedraogo">S. Ouedraogo</name><affiliation><nlm:aff id="Aff233">Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle, Ouagadougou, Burkina Faso</nlm:aff></affiliation></author><author><name sortKey="Paggiaro, P" sort="Paggiaro, P" uniqKey="Paggiaro P" first="P." last="Paggiaro">P. Paggiaro</name><affiliation><nlm:aff id="Aff234">Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Pali Scholl, I" sort="Pali Scholl, I" uniqKey="Pali Scholl I" first="I." last="Pali-Schöll">I. Pali-Schöll</name><affiliation><nlm:aff id="Aff235">Department of Comparative Medicine, Messerli Research Institute of the University of Veterinary Medicine, Medical University, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Palkonen, S" sort="Palkonen, S" uniqKey="Palkonen S" first="S." last="Palkonen">S. Palkonen</name><affiliation><nlm:aff id="Aff20">EFA European Federation of Allergy and Airways Diseases Patients’ Associations, Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Panzner, P" sort="Panzner, P" uniqKey="Panzner P" first="P." last="Panzner">P. Panzner</name><affiliation><nlm:aff id="Aff236">Department of Immunology and Allergology, Faculty of Medicine and Faculty Hospital in Pilsen, Charles University in Prague, Pilsen, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Papi, A" sort="Papi, A" uniqKey="Papi A" first="A." last="Papi">A. Papi</name><affiliation><nlm:aff id="Aff237">Respiratory Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy</nlm:aff></affiliation></author><author><name sortKey="Park, H S" sort="Park, H S" uniqKey="Park H" first="H. S." last="Park">H. S. Park</name><affiliation><nlm:aff id="Aff238">Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea</nlm:aff></affiliation></author><author><name sortKey="Passalacqua, G" sort="Passalacqua, G" uniqKey="Passalacqua G" first="G." last="Passalacqua">G. Passalacqua</name><affiliation><nlm:aff id="Aff15">Asthma and Allergy Clinic, Humanitas University, Rozzano, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Pedersen, S" sort="Pedersen, S" uniqKey="Pedersen S" first="S." last="Pedersen">S. Pedersen</name><affiliation><nlm:aff id="Aff239">University of Southern Denmark, Kolding, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pereira, A M" sort="Pereira, A M" uniqKey="Pereira A" first="A. M." last="Pereira">A. M. Pereira</name><affiliation><nlm:aff id="Aff24">Center for Research in Health Technologies and Information Systems - CINTESIS, Universidade do Porto, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff25">Allergy Unit, Instituto CUF Porto e Hospital CUF Porto, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff26">Health Information and Decision Sciences Department - CIDES, Faculdade de Medicina, Universidade do Porto, Rua Dr. Plácido da Costa, s/n, 4200-450 Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff240">Allergy Unit, CUF-Porto Hospital and Institute, Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Pfaar, O" sort="Pfaar, O" uniqKey="Pfaar O" first="O." last="Pfaar">O. Pfaar</name><affiliation><nlm:aff id="Aff34">Center for Rhinology and Allergology, Wiesbaden, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff241">Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Picard, R" sort="Picard, R" uniqKey="Picard R" first="R." last="Picard">R. Picard</name><affiliation><nlm:aff id="Aff242">Conseil Général de l’Economie, Ministère de l’Economie, de l’Industrie et du Numérique, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Pigearias, B" sort="Pigearias, B" uniqKey="Pigearias B" first="B." last="Pigearias">B. Pigearias</name><affiliation><nlm:aff id="Aff243">Société de Pneumologie de Langue Française, Espace francophone de Pneumologie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Pin, I" sort="Pin, I" uniqKey="Pin I" first="I." last="Pin">I. Pin</name><affiliation><nlm:aff id="Aff244">Département de pédiatrie, CHU de Grenoble, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Plavec, D" sort="Plavec, D" uniqKey="Plavec D" first="D." last="Plavec">D. Plavec</name><affiliation><nlm:aff id="Aff245">Children’s Hospital Srebrnjak, Zagreb, Croatia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff246">School of Medicine, University J.J. Strossmayer, Osijek, Croatia</nlm:aff></affiliation></author><author><name sortKey="Pohl, W" sort="Pohl, W" uniqKey="Pohl W" first="W." last="Pohl">W. Pohl</name><affiliation><nlm:aff id="Aff247">Karl Landsteiner Institute for Clinical and Experimental Pneumology, Hietzing Hospital, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Popov, T A" sort="Popov, T A" uniqKey="Popov T" first="T. A." last="Popov">T. A. Popov</name><affiliation><nlm:aff id="Aff248">Clinic of Allergy and Asthma, Medical University Sofia, Sofia, Bulgaria</nlm:aff></affiliation></author><author><name sortKey="Portejoie, F" sort="Portejoie, F" uniqKey="Portejoie F" first="F." last="Portejoie">F. Portejoie</name><affiliation><nlm:aff id="Aff2">MACVIA-France, Contre les MAladies Chroniques pour un VIeillissement Actif en France, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Postma, D" sort="Postma, D" uniqKey="Postma D" first="D." last="Postma">D. Postma</name><affiliation><nlm:aff id="Aff249">University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Poulsen, L K" sort="Poulsen, L K" uniqKey="Poulsen L" first="L. K." last="Poulsen">L. K. Poulsen</name><affiliation><nlm:aff id="Aff250">Laboratory of Medical Allergology, Allergy Clinic, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Price, D" sort="Price, D" uniqKey="Price D" first="D." last="Price">D. Price</name><affiliation><nlm:aff id="Aff251">Academic Centre of Primary Care, University of Aberdeen, Aberdeen, Scotland, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff252">Research in Real-Life, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Rabe, K F" sort="Rabe, K F" uniqKey="Rabe K" first="K. F." last="Rabe">K. F. Rabe</name><affiliation><nlm:aff id="Aff253">LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research (DZL), Grosshansdorf, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff254">Department of Medicine, Christian Albrechts University, Airway Research Center North, German Center for Lung Research (DZL), Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Raciborski, F" sort="Raciborski, F" uniqKey="Raciborski F" first="F." last="Raciborski">F. Raciborski</name><affiliation><nlm:aff id="Aff49">Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Roberts, G" sort="Roberts, G" uniqKey="Roberts G" first="G." last="Roberts">G. Roberts</name><affiliation><nlm:aff id="Aff255">NHS Foundation Trust, University Hospitals of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Robalo Cordeiro, C" sort="Robalo Cordeiro, C" uniqKey="Robalo Cordeiro C" first="C." last="Robalo-Cordeiro">C. Robalo-Cordeiro</name><affiliation><nlm:aff id="Aff256">Centre of Pneumology, Coimbra University Hospital, Coimbra, Portugal</nlm:aff></affiliation></author><author><name sortKey="Rodenas, F" sort="Rodenas, F" uniqKey="Rodenas F" first="F." last="Rodenas">F. Rodenas</name><affiliation><nlm:aff id="Aff257">Polibienestar Research Institute, University of Valencia, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Rodriguez Ma As, L" sort="Rodriguez Ma As, L" uniqKey="Rodriguez Ma As L" first="L." last="Rodriguez-Ma As">L. Rodriguez-Ma As</name><affiliation><nlm:aff id="Aff258">Department of Geriatrics, Getafe University Hospital, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Rolland, C" sort="Rolland, C" uniqKey="Rolland C" first="C." last="Rolland">C. Rolland</name><affiliation><nlm:aff id="Aff259">Association Asthme et Allergie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Roman Rodriguez, M" sort="Roman Rodriguez, M" uniqKey="Roman Rodriguez M" first="M." last="Roman Rodriguez">M. Roman Rodriguez</name><affiliation><nlm:aff id="Aff260">Primary Care Respiratory Research Unit, Institutode Investigación Sanitaria de Palma IdisPa, Palma de Mallorca, Spain</nlm:aff></affiliation></author><author><name sortKey="Romano, A" sort="Romano, A" uniqKey="Romano A" first="A." last="Romano">A. Romano</name><affiliation><nlm:aff id="Aff261">Allergy Unit, Complesso Integrato Columbus, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Rosado Pinto, J" sort="Rosado Pinto, J" uniqKey="Rosado Pinto J" first="J." last="Rosado-Pinto">J. Rosado-Pinto</name><affiliation><nlm:aff id="Aff262">Serviço de Imunoalergologia, Hospital da Luz, Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Rosario, N" sort="Rosario, N" uniqKey="Rosario N" first="N." last="Rosario">N. Rosario</name><affiliation><nlm:aff id="Aff263">Hospital de Clinicas, University of Parana, Curitiba, Brazil</nlm:aff></affiliation></author><author><name sortKey="Rottem, M" sort="Rottem, M" uniqKey="Rottem M" first="M." last="Rottem">M. Rottem</name><affiliation><nlm:aff id="Aff264">Division of Allergy Asthma and Clinical Immunology, Emek Medical Center, Afula, Israel</nlm:aff></affiliation></author><author><name sortKey="Sanchez Borges, M" sort="Sanchez Borges, M" uniqKey="Sanchez Borges M" first="M." last="Sanchez-Borges">M. Sanchez-Borges</name><affiliation><nlm:aff id="Aff265">Allergy and Clinical Immunology Department, Centro Médico-Docente La Trinidad and Clínica El Avila, Caracas, Venezuela</nlm:aff></affiliation></author><author><name sortKey="Sastre Dominguez, J" sort="Sastre Dominguez, J" uniqKey="Sastre Dominguez J" first="J." last="Sastre-Dominguez">J. Sastre-Dominguez</name><affiliation><nlm:aff id="Aff266">Faculty of Medicine, Autononous University of Madrid, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Scadding, G K" sort="Scadding, G K" uniqKey="Scadding G" first="G. K." last="Scadding">G. K. Scadding</name><affiliation><nlm:aff id="Aff267">The Royal National TNE Hospital, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Scichilone, N" sort="Scichilone, N" uniqKey="Scichilone N" first="N." last="Scichilone">N. Scichilone</name><affiliation><nlm:aff id="Aff268">DIBIMIS, University of Palermo, Palermo, Italy</nlm:aff></affiliation></author><author><name sortKey="Schmid Grendelmeier, P" sort="Schmid Grendelmeier, P" uniqKey="Schmid Grendelmeier P" first="P." last="Schmid-Grendelmeier">P. Schmid-Grendelmeier</name><affiliation><nlm:aff id="Aff269">Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Serrano, E" sort="Serrano, E" uniqKey="Serrano E" first="E." last="Serrano">E. Serrano</name><affiliation><nlm:aff id="Aff270">Otolaryngology and Head and Neck Surgery, CHU Rangueil-Larrey, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Shields, M" sort="Shields, M" uniqKey="Shields M" first="M." last="Shields">M. Shields</name><affiliation><nlm:aff id="Aff271">Child Health, Queen’s University, Belfast, Northern Ireland, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff272">Royal Belfast Hospital for Sick Children, Belfast, Northern Ireland, UK</nlm:aff></affiliation></author><author><name sortKey="Siroux, V" sort="Siroux, V" uniqKey="Siroux V" first="V." last="Siroux">V. Siroux</name><affiliation><nlm:aff id="Aff273">INSERM, Université Grenoble Alpes, IAB, U 1209, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Université Joseph Fourier, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Sisul, J C" sort="Sisul, J C" uniqKey="Sisul J" first="J. C." last="Sisul">J. C. Sisul</name><affiliation><nlm:aff id="Aff274">Sociedad Paraguaya de Alergia Asma e Inmunologıa, Asunción, Paraguay</nlm:aff></affiliation></author><author><name sortKey="Skrindo, I" sort="Skrindo, I" uniqKey="Skrindo I" first="I." last="Skrindo">I. Skrindo</name><affiliation><nlm:aff id="Aff109">Department of Paediatrics, Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="Aff195">Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Smit, H A" sort="Smit, H A" uniqKey="Smit H" first="H. A." last="Smit">H. A. Smit</name><affiliation><nlm:aff id="Aff275">Julius Center of Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sole, D" sort="Sole, D" uniqKey="Sole D" first="D." last="Solé">D. Solé</name><affiliation><nlm:aff id="Aff276">Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Sooronbaev, T" sort="Sooronbaev, T" uniqKey="Sooronbaev T" first="T." last="Sooronbaev">T. Sooronbaev</name><affiliation><nlm:aff id="Aff277">Kyrgyzstan National Centre of Cardiology and Internal Medicine, Euro-Asian Respiratory Society, Bishkek, Kyrgyzstan</nlm:aff></affiliation></author><author><name sortKey="Spranger, O" sort="Spranger, O" uniqKey="Spranger O" first="O." last="Spranger">O. Spranger</name><affiliation><nlm:aff id="Aff146">Global Allergy and Asthma Platform GAAPP, Altgasse 8-10, 1130 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Stelmach, R" sort="Stelmach, R" uniqKey="Stelmach R" first="R." last="Stelmach">R. Stelmach</name><affiliation><nlm:aff id="Aff278">Pulmonary Division, Heart Institute (InCor), Hospital da Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Sterk, P J" sort="Sterk, P J" uniqKey="Sterk P" first="P. J." last="Sterk">P. J. Sterk</name><affiliation><nlm:aff id="Aff279">Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Strandberg, T" sort="Strandberg, T" uniqKey="Strandberg T" first="T." last="Strandberg">T. Strandberg</name><affiliation><nlm:aff id="Aff280">European Union Geriatric Medicine Society (EUGMS), Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Sunyer, J" sort="Sunyer, J" uniqKey="Sunyer J" first="J." last="Sunyer">J. Sunyer</name><affiliation><nlm:aff id="Aff69">Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff70">IMIM (Hospital del Mar Research Institute), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff71">CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff72">Universitat Pompeu Fabra (UPF), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Thijs, C" sort="Thijs, C" uniqKey="Thijs C" first="C." last="Thijs">C. Thijs</name><affiliation><nlm:aff id="Aff281">Department of Epidemiology, CAPHRI School of Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Triggiani, M" sort="Triggiani, M" uniqKey="Triggiani M" first="M." last="Triggiani">M. Triggiani</name><affiliation><nlm:aff id="Aff53">Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy</nlm:aff></affiliation></author><author><name sortKey="Valenta, R" sort="Valenta, R" uniqKey="Valenta R" first="R." last="Valenta">R. Valenta</name><affiliation><nlm:aff id="Aff197">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Valero, A" sort="Valero, A" uniqKey="Valero A" first="A." last="Valero">A. Valero</name><affiliation><nlm:aff id="Aff282">Pneumology and Allergy Department, Hospital Clínic, Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Van Eerd, M" sort="Van Eerd, M" uniqKey="Van Eerd M" first="M." last="Van Eerd">M. 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Bousquet</name><affiliation><nlm:aff id="Aff1">Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2">MACVIA-France, Contre les MAladies Chroniques pour un VIeillissement Actif en France, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3">INSERM, U1168, Ageing and Chronic Diseases Epidemiological and Public Health Approaches, 94800 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff312">CHRU Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France</nlm:aff></affiliation></author><author><name sortKey="Hellings, P W" sort="Hellings, P W" uniqKey="Hellings P" first="P. W." last="Hellings">P. W. Hellings</name><affiliation><nlm:aff id="Aff4">Laboratory of Clinical Immunology, Department of Microbiology and Immunology, KU Leuven, Louvain, Belgium</nlm:aff></affiliation></author><author><name sortKey="Agache, I" sort="Agache, I" uniqKey="Agache I" first="I." last="Agache">I. Agache</name><affiliation><nlm:aff id="Aff5">Transylvania University Brasov, Brasov, Romania</nlm:aff></affiliation></author><author><name sortKey="Bedbrook, A" sort="Bedbrook, A" uniqKey="Bedbrook A" first="A." last="Bedbrook">A. Bedbrook</name><affiliation><nlm:aff id="Aff2">MACVIA-France, Contre les MAladies Chroniques pour un VIeillissement Actif en France, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Bachert, C" sort="Bachert, C" uniqKey="Bachert C" first="C." last="Bachert">C. Bachert</name><affiliation><nlm:aff id="Aff6">Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Bergmann, K C" sort="Bergmann, K C" uniqKey="Bergmann K" first="K. C." last="Bergmann">K. C. Bergmann</name><affiliation><nlm:aff id="Aff7">Allergy-Centre-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff8">Global Allergy and Asthma European Network (GA²LEN), Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Bewick, M" sort="Bewick, M" uniqKey="Bewick M" first="M." last="Bewick">M. Bewick</name><affiliation><nlm:aff id="Aff9">iQ4U Consultants Ltd, London, UK</nlm:aff></affiliation></author><author><name sortKey="Bindslev Jensen, C" sort="Bindslev Jensen, C" uniqKey="Bindslev Jensen C" first="C." last="Bindslev-Jensen">C. Bindslev-Jensen</name><affiliation><nlm:aff id="Aff10">Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bosnic Anticevitch, S" sort="Bosnic Anticevitch, S" uniqKey="Bosnic Anticevitch S" first="S." last="Bosnic-Anticevitch">S. Bosnic-Anticevitch</name><affiliation><nlm:aff id="Aff11">Woolcock Institute of Medical Research, University of Sydney and Sydney Local Health District, Glebe, NSW Australia</nlm:aff></affiliation></author><author><name sortKey="Bucca, C" sort="Bucca, C" uniqKey="Bucca C" first="C." last="Bucca">C. Bucca</name><affiliation><nlm:aff id="Aff12">University Pneumology Unit-AOU Molinette, Hospital City of Health and Science of Torino, Turin, Italy</nlm:aff></affiliation></author><author><name sortKey="Caimmi, D P" sort="Caimmi, D P" uniqKey="Caimmi D" first="D. P." last="Caimmi">D. P. Caimmi</name><affiliation><nlm:aff id="Aff13">Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Camargos, P A M" sort="Camargos, P A M" uniqKey="Camargos P" first="P. A. M." last="Camargos">P. A. M. Camargos</name><affiliation><nlm:aff id="Aff14">Department of Pediatrics, Medical School, Federal University of Minas Gerais, Belo Horizonte, Brazil</nlm:aff></affiliation></author><author><name sortKey="Canonica, G W" sort="Canonica, G W" uniqKey="Canonica G" first="G. W." last="Canonica">G. W. Canonica</name><affiliation><nlm:aff id="Aff15">Asthma and Allergy Clinic, Humanitas University, Rozzano, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Casale, T" sort="Casale, T" uniqKey="Casale T" first="T." last="Casale">T. Casale</name><affiliation><nlm:aff id="Aff16">Division of Allergy/Immunology, University of South Florida, Tampa, FL USA</nlm:aff></affiliation></author><author><name sortKey="Chavannes, N H" sort="Chavannes, N H" uniqKey="Chavannes N" first="N. H." last="Chavannes">N. H. Chavannes</name><affiliation><nlm:aff id="Aff17">Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cruz, A A" sort="Cruz, A A" uniqKey="Cruz A" first="A. A." last="Cruz">A. A. Cruz</name><affiliation><nlm:aff id="Aff18">ProAR – Nucleo de Excelencia em Asma, Federal University of Bahia, Salvador, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="Aff19">GARD Executive Committee, Salvador, Bahia Brazil</nlm:aff></affiliation></author><author><name sortKey="De Carlo, G" sort="De Carlo, G" uniqKey="De Carlo G" first="G." last="De Carlo">G. De Carlo</name><affiliation><nlm:aff id="Aff20">EFA European Federation of Allergy and Airways Diseases Patients’ Associations, Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Dahl, R" sort="Dahl, R" uniqKey="Dahl R" first="R." last="Dahl">R. Dahl</name><affiliation><nlm:aff id="Aff18">ProAR – Nucleo de Excelencia em Asma, Federal University of Bahia, Salvador, Brazil</nlm:aff></affiliation></author><author><name sortKey="Demoly, P" sort="Demoly, P" uniqKey="Demoly P" first="P." last="Demoly">P. Demoly</name><affiliation><nlm:aff id="Aff13">Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff21">EPAR U707 INSERM, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff22">EPAR UMR-S UPMC, Paris VI, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Devillier, P" sort="Devillier, P" uniqKey="Devillier P" first="P." last="Devillier">P. Devillier</name><affiliation><nlm:aff id="Aff23">Laboratoire de Pharmacologie Respiratoire UPRES EA220, Hôpital Foch, Suresnes Université Versailles, Saint-Quentin, France</nlm:aff></affiliation></author><author><name sortKey="Fonseca, J" sort="Fonseca, J" uniqKey="Fonseca J" first="J." last="Fonseca">J. Fonseca</name><affiliation><nlm:aff id="Aff24">Center for Research in Health Technologies and Information Systems - CINTESIS, Universidade do Porto, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff25">Allergy Unit, Instituto CUF Porto e Hospital CUF Porto, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff26">Health Information and Decision Sciences Department - CIDES, Faculdade de Medicina, Universidade do Porto, Rua Dr. Plácido da Costa, s/n, 4200-450 Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Fokkens, W J" sort="Fokkens, W J" uniqKey="Fokkens W" first="W. J." last="Fokkens">W. J. Fokkens</name><affiliation><nlm:aff id="Aff27">Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Guldemond, N A" sort="Guldemond, N A" uniqKey="Guldemond N" first="N. A." last="Guldemond">N. A. Guldemond</name><affiliation><nlm:aff id="Aff28">Institute of Health Policy and Management IBMG, Erasmus University, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Haahtela, T" sort="Haahtela, T" uniqKey="Haahtela T" first="T." last="Haahtela">T. Haahtela</name><affiliation><nlm:aff id="Aff29">Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Illario, M" sort="Illario, M" uniqKey="Illario M" first="M." last="Illario">M. Illario</name><affiliation><nlm:aff id="Aff30">Federico II University Hospital Naples (R&D and DISMET), Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Just, J" sort="Just, J" uniqKey="Just J" first="J." last="Just">J. Just</name><affiliation><nlm:aff id="Aff31">Allergology Department, Centre de l’Asthme et des Allergies, Hôpital d’Enfants Armand-Trousseau (APHP), Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Equipe EPAR, 75013 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Keil, T" sort="Keil, T" uniqKey="Keil T" first="T." last="Keil">T. Keil</name><affiliation><nlm:aff id="Aff32">Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff33">Institute for Clinical Epidemiology and Biometry, University of Wuerzburg, Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Klimek, L" sort="Klimek, L" uniqKey="Klimek L" first="L." last="Klimek">L. Klimek</name><affiliation><nlm:aff id="Aff34">Center for Rhinology and Allergology, Wiesbaden, Germany</nlm:aff></affiliation></author><author><name sortKey="Kuna, P" sort="Kuna, P" uniqKey="Kuna P" first="P." last="Kuna">P. Kuna</name><affiliation><nlm:aff id="Aff35">Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland</nlm:aff></affiliation></author><author><name sortKey="Larenas Linnemann, D" sort="Larenas Linnemann, D" uniqKey="Larenas Linnemann D" first="D." last="Larenas-Linnemann">D. Larenas-Linnemann</name><affiliation><nlm:aff id="Aff36">Clínica de Alergia, Asma y Pediatría, Hospital Médica Sur, Mexico City, Mexico</nlm:aff></affiliation></author><author><name sortKey="Morais Almeida, M" sort="Morais Almeida, M" uniqKey="Morais Almeida M" first="M." last="Morais-Almeida">M. Morais-Almeida</name><affiliation><nlm:aff id="Aff37">Allergy and Clinical Immunology Department, Hospital CUF-Descobertas, Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Mullol, J" sort="Mullol, J" uniqKey="Mullol J" first="J." last="Mullol">J. Mullol</name><affiliation><nlm:aff id="Aff38">ENT Department, Hospital Clinic, Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, Universitat de Barcelona, Barcelona, Catalonia Spain</nlm:aff></affiliation></author><author><name sortKey="Murray, R" sort="Murray, R" uniqKey="Murray R" first="R." last="Murray">R. Murray</name><affiliation><nlm:aff id="Aff39">MedScript Ltd, Dundalk, County Louth, Ireland</nlm:aff></affiliation></author><author><name sortKey="Naclerio, R" sort="Naclerio, R" uniqKey="Naclerio R" first="R." last="Naclerio">R. Naclerio</name><affiliation><nlm:aff id="Aff40">Section of Otolaryngology-Head and Neck Surgery, The University of Chicago Medical Center and The Pritzker School of Medicine, The University of Chicago, Chicago, IL USA</nlm:aff></affiliation></author><author><name sortKey="O Ehir, R E" sort="O Ehir, R E" uniqKey="O Ehir R" first="R. E." last="O Ehir">R. E. O Ehir</name><affiliation><nlm:aff id="Aff41">Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff42">Department of Immunology, Monash University, Melbourne, VIC Australia</nlm:aff></affiliation></author><author><name sortKey="Papadopoulos, N G" sort="Papadopoulos, N G" uniqKey="Papadopoulos N" first="N. G." last="Papadopoulos">N. G. Papadopoulos</name><affiliation><nlm:aff id="Aff43">Center for Pediatrics and Child Health, Institute of Human Development, Royal Manchester Children’s Hospital, University of Manchester, Manchester, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff44">Allergy Department, 2nd Pediatric Clinic, Athens General Children’s Hospital “P&A Kyriakou”, University of Athens, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Pawankar, R" sort="Pawankar, R" uniqKey="Pawankar R" first="R." last="Pawankar">R. Pawankar</name><affiliation><nlm:aff id="Aff45">Department of Pediatrics, Nippon Medical School, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Potter, P" sort="Potter, P" uniqKey="Potter P" first="P." last="Potter">P. Potter</name><affiliation><nlm:aff id="Aff46">Allergy Diagnostic and Clinical Research Unit, University of Cape Town Lung Institute, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Ryan, D" sort="Ryan, D" uniqKey="Ryan D" first="D." last="Ryan">D. Ryan</name><affiliation><nlm:aff id="Aff47">Woodbrook Medical Centre, Loughborough, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff48">Allergy and Respiratory Research Group, The University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Samolinski, B" sort="Samolinski, B" uniqKey="Samolinski B" first="B." last="Samolinski">B. Samolinski</name><affiliation><nlm:aff id="Aff49">Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Schunemann, H J" sort="Schunemann, H J" uniqKey="Schunemann H" first="H. J." last="Schunemann">H. J. Schunemann</name><affiliation><nlm:aff id="Aff50">Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada</nlm:aff></affiliation></author><author><name sortKey="Sheikh, A" sort="Sheikh, A" uniqKey="Sheikh A" first="A." last="Sheikh">A. Sheikh</name><affiliation><nlm:aff id="Aff51">Allergy and Respiratory Research Group, Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Simons, F E R" sort="Simons, F E R" uniqKey="Simons F" first="F. E. R." last="Simons">F. E. R. Simons</name><affiliation><nlm:aff id="Aff52">Department of Pediatrics and Child Health, Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, MB Canada</nlm:aff></affiliation></author><author><name sortKey="Stellato, C" sort="Stellato, C" uniqKey="Stellato C" first="C." last="Stellato">C. Stellato</name><affiliation><nlm:aff id="Aff53">Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy</nlm:aff></affiliation></author><author><name sortKey="Todo Bom, A" sort="Todo Bom, A" uniqKey="Todo Bom A" first="A." last="Todo-Bom">A. Todo-Bom</name><affiliation><nlm:aff id="Aff54">Centre of Pneumology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal</nlm:aff></affiliation></author><author><name sortKey="Tomazic, P V" sort="Tomazic, P V" uniqKey="Tomazic P" first="P. V." last="Tomazic">P. V. Tomazic</name><affiliation><nlm:aff id="Aff55">Department of ENT, Medical University of Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Valiulis, A" sort="Valiulis, A" uniqKey="Valiulis A" first="A." last="Valiulis">A. Valiulis</name><affiliation><nlm:aff id="Aff56">Clinic of Children’s Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania</nlm:aff></affiliation><affiliation><nlm:aff id="Aff57">Public Health Institute, Vilnius University, Vilnius, Lithuania</nlm:aff></affiliation><affiliation><nlm:aff id="Aff58">European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Valovirta, E" sort="Valovirta, E" uniqKey="Valovirta E" first="E." last="Valovirta">E. Valovirta</name><affiliation><nlm:aff id="Aff59">Department of Lung Diseases and Clinical Allergology, University of Turku, Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff60">Allergy Clinic, Terveystalo, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Ventura, M T" sort="Ventura, M T" uniqKey="Ventura M" first="M. T." last="Ventura">M. T. Ventura</name><affiliation><nlm:aff id="Aff61">Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy</nlm:aff></affiliation></author><author><name sortKey="Wickman, M" sort="Wickman, M" uniqKey="Wickman M" first="M." last="Wickman">M. Wickman</name><affiliation><nlm:aff id="Aff62">Sachs’ Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="Aff63">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Young, I" sort="Young, I" uniqKey="Young I" first="I." last="Young">I. Young</name><affiliation><nlm:aff id="Aff64">Queen’s University, Belfast, Northern Ireland, UK</nlm:aff></affiliation></author><author><name sortKey="Yorgancioglu, A" sort="Yorgancioglu, A" uniqKey="Yorgancioglu A" first="A." last="Yorgancioglu">A. Yorgancioglu</name><affiliation><nlm:aff id="Aff65">Department of Pulmonology, Celal Bayar University, Manisa, Turkey</nlm:aff></affiliation></author><author><name sortKey="Zuberbier, T" sort="Zuberbier, T" uniqKey="Zuberbier T" first="T." last="Zuberbier">T. Zuberbier</name><affiliation><nlm:aff id="Aff7">Allergy-Centre-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff8">Global Allergy and Asthma European Network (GA²LEN), Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Aberer, W" sort="Aberer, W" uniqKey="Aberer W" first="W." last="Aberer">W. Aberer</name><affiliation><nlm:aff id="Aff66">Department of Dermatology, Medical University of Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Akdis, C A" sort="Akdis, C A" uniqKey="Akdis C" first="C. A." last="Akdis">C. A. Akdis</name><affiliation><nlm:aff id="Aff67">Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Akdis, M" sort="Akdis, M" uniqKey="Akdis M" first="M." last="Akdis">M. Akdis</name><affiliation><nlm:aff id="Aff67">Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Annesi Maesano, I" sort="Annesi Maesano, I" uniqKey="Annesi Maesano I" first="I." last="Annesi-Maesano">I. Annesi-Maesano</name><affiliation><nlm:aff id="Aff21">EPAR U707 INSERM, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff22">EPAR UMR-S UPMC, Paris VI, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Ankri, J" sort="Ankri, J" uniqKey="Ankri J" first="J." last="Ankri">J. Ankri</name><affiliation><nlm:aff id="Aff3">INSERM, U1168, Ageing and Chronic Diseases Epidemiological and Public Health Approaches, 94800 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Ansotegui, I J" sort="Ansotegui, I J" uniqKey="Ansotegui I" first="I. J." last="Ansotegui">I. J. Ansotegui</name><affiliation><nlm:aff id="Aff68">Department of Allergy and Immunology, Hospital Quirón Bizkaia, Erandio, Spain</nlm:aff></affiliation></author><author><name sortKey="Anto, J M" sort="Anto, J M" uniqKey="Anto J" first="J. M." last="Anto">J. M. Anto</name><affiliation><nlm:aff id="Aff69">Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff70">IMIM (Hospital del Mar Research Institute), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff71">CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff72">Universitat Pompeu Fabra (UPF), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Arnavielhe, S" sort="Arnavielhe, S" uniqKey="Arnavielhe S" first="S." last="Arnavielhe">S. Arnavielhe</name><affiliation><nlm:aff id="Aff73">Kyomed, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Asarnoj, A" sort="Asarnoj, A" uniqKey="Asarnoj A" first="A." last="Asarnoj">A. Asarnoj</name><affiliation><nlm:aff id="Aff74">Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="Aff75">Department of Pediatric Pulmonology and Allergy, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Arshad, H" sort="Arshad, H" uniqKey="Arshad H" first="H." last="Arshad">H. Arshad</name><affiliation><nlm:aff id="Aff76">David Hide Asthma and Allergy Research Centre, Isle of Wight, UK</nlm:aff></affiliation></author><author><name sortKey="Avolio, F" sort="Avolio, F" uniqKey="Avolio F" first="F." last="Avolio">F. Avolio</name><affiliation><nlm:aff id="Aff77">Regionie Puglia, Bari, Italy</nlm:aff></affiliation></author><author><name sortKey="Baiardini, I" sort="Baiardini, I" uniqKey="Baiardini I" first="I." last="Baiardini">I. Baiardini</name><affiliation><nlm:aff id="Aff15">Asthma and Allergy Clinic, Humanitas University, Rozzano, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Barbara, C" sort="Barbara, C" uniqKey="Barbara C" first="C." last="Barbara">C. Barbara</name><affiliation><nlm:aff id="Aff78">Faculdade de Medicina de Lisboa, Portuguese National Programme for Respiratory Diseases (PNDR), Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Barbagallo, M" sort="Barbagallo, M" uniqKey="Barbagallo M" first="M." last="Barbagallo">M. Barbagallo</name><affiliation><nlm:aff id="Aff79">Geriatric Unit, Department of Internal Medicine (DIBIMIS), University of Palermo, Palermo, Italy</nlm:aff></affiliation></author><author><name sortKey="Bateman, E D" sort="Bateman, E D" uniqKey="Bateman E" first="E. D." last="Bateman">E. D. Bateman</name><affiliation><nlm:aff id="Aff80">Department of Medicine, University of Cape Town, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Beghe, B" sort="Beghe, B" uniqKey="Beghe B" first="B." last="Beghé">B. Beghé</name><affiliation><nlm:aff id="Aff81">Section of Respiratory Disease, Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy</nlm:aff></affiliation></author><author><name sortKey="Bel, E H" sort="Bel, E H" uniqKey="Bel E" first="E. H." last="Bel">E. H. Bel</name><affiliation><nlm:aff id="Aff82">Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bennoor, K S" sort="Bennoor, K S" uniqKey="Bennoor K" first="K. S." last="Bennoor">K. S. Bennoor</name><affiliation><nlm:aff id="Aff83">Department of Respiratory Medicine, National Institute of Diseases of the Chest and Hospital, Dhaka, Bangladesh</nlm:aff></affiliation></author><author><name sortKey="Benson, M" sort="Benson, M" uniqKey="Benson M" first="M." last="Benson">M. Benson</name><affiliation><nlm:aff id="Aff84">Centre for Individualized Medicine, Department of Pediatrics, Faculty of Medicine, Linköping University, 58185 Linköping, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bialoszewski, A Z" sort="Bialoszewski, A Z" uniqKey="Bialoszewski A" first="A. Z." last="Białoszewski">A. Z. Białoszewski</name><affiliation><nlm:aff id="Aff49">Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Bieber, T" sort="Bieber, T" uniqKey="Bieber T" first="T." last="Bieber">T. Bieber</name><affiliation><nlm:aff id="Aff85">Department of Dermatology and Allergy, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Bjermer, L" sort="Bjermer, L" uniqKey="Bjermer L" first="L." last="Bjermer">L. Bjermer</name><affiliation><nlm:aff id="Aff86">Department of Respiratory Medicine and Allergology, University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Blain, H" sort="Blain, H" uniqKey="Blain H" first="H." last="Blain">H. Blain</name><affiliation><nlm:aff id="Aff87">Department of Geriatrics, Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff88">EA 2991, Euromov, University Montpellier, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Blasi, F" sort="Blasi, F" uniqKey="Blasi F" first="F." last="Blasi">F. Blasi</name><affiliation><nlm:aff id="Aff89">Department of Pathophysiology and Transplantation, IRCCS Fondazione Ca’Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Boner, A L" sort="Boner, A L" uniqKey="Boner A" first="A. L." last="Boner">A. L. Boner</name><affiliation><nlm:aff id="Aff90">Pediatric Department, University of Verona Hospital, Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Bonini, M" sort="Bonini, M" uniqKey="Bonini M" first="M." last="Bonini">M. Bonini</name><affiliation><nlm:aff id="Aff91">Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Bonini, S" sort="Bonini, S" uniqKey="Bonini S" first="S." last="Bonini">S. Bonini</name><affiliation><nlm:aff id="Aff92">Second University of Naples and Institute of Translational Medicine, Italian National Research Council, Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Bosse, I" sort="Bosse, I" uniqKey="Bosse I" first="I." last="Bosse">I. Bosse</name><affiliation><nlm:aff id="Aff93">La Rochelle, France</nlm:aff></affiliation></author><author><name sortKey="Bouchard, J" sort="Bouchard, J" uniqKey="Bouchard J" first="J." last="Bouchard">J. Bouchard</name><affiliation><nlm:aff id="Aff94">Montreal, QC Canada</nlm:aff></affiliation></author><author><name sortKey="Boulet, L P" sort="Boulet, L P" uniqKey="Boulet L" first="L. P." last="Boulet">L. P. Boulet</name><affiliation><nlm:aff id="Aff95">Quebec Heart and Lung Institute, Laval University, Quebec City, QC Canada</nlm:aff></affiliation></author><author><name sortKey="Bourret, R" sort="Bourret, R" uniqKey="Bourret R" first="R." last="Bourret">R. Bourret</name><affiliation><nlm:aff id="Aff1">Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Bousquet, P J" sort="Bousquet, P J" uniqKey="Bousquet P" first="P. J." last="Bousquet">P. J. Bousquet</name><affiliation><nlm:aff id="Aff21">EPAR U707 INSERM, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Braido, F" sort="Braido, F" uniqKey="Braido F" first="F." last="Braido">F. Braido</name><affiliation><nlm:aff id="Aff15">Asthma and Allergy Clinic, Humanitas University, Rozzano, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Briggs, A H" sort="Briggs, A H" uniqKey="Briggs A" first="A. H." last="Briggs">A. H. Briggs</name><affiliation><nlm:aff id="Aff96">Health Economics and Health Technology Assessment, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Brightling, C E" sort="Brightling, C E" uniqKey="Brightling C" first="C. E." last="Brightling">C. E. Brightling</name><affiliation><nlm:aff id="Aff97">Institute of Lung Health, Respiratory Biomedical Unit, University Hospitals of Leicester NHS Trust, Leicestershire, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff98">Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK</nlm:aff></affiliation></author><author><name sortKey="Brozek, J" sort="Brozek, J" uniqKey="Brozek J" first="J." last="Brozek">J. Brozek</name><affiliation><nlm:aff id="Aff50">Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada</nlm:aff></affiliation></author><author><name sortKey="Buhl, R" sort="Buhl, R" uniqKey="Buhl R" first="R." last="Buhl">R. Buhl</name><affiliation><nlm:aff id="Aff99">Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany</nlm:aff></affiliation></author><author><name sortKey="Bunu, C" sort="Bunu, C" uniqKey="Bunu C" first="C." last="Bunu">C. Bunu</name><affiliation><nlm:aff id="Aff100">University of Medicine and Pharmacy Victor Babes, Timisoara, Romania</nlm:aff></affiliation></author><author><name sortKey="Burte, E" sort="Burte, E" uniqKey="Burte E" first="E." last="Burte">E. Burte</name><affiliation><nlm:aff id="Aff3">INSERM, U1168, Ageing and Chronic Diseases Epidemiological and Public Health Approaches, 94800 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Bush, A" sort="Bush, A" uniqKey="Bush A" first="A." last="Bush">A. Bush</name><affiliation><nlm:aff id="Aff101">Royal Brompton Hospital NHS, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Caballero Fonseca, F" sort="Caballero Fonseca, F" uniqKey="Caballero Fonseca F" first="F." last="Caballero-Fonseca">F. Caballero-Fonseca</name><affiliation><nlm:aff id="Aff102">Centro Medico Docente La Trinidad, Caracas, Venezuela</nlm:aff></affiliation></author><author><name sortKey="Calderon, M A" sort="Calderon, M A" uniqKey="Calderon M" first="M. A." last="Calderon">M. A. Calderon</name><affiliation><nlm:aff id="Aff101">Royal Brompton Hospital NHS, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff103">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Camuzat, T" sort="Camuzat, T" uniqKey="Camuzat T" first="T." last="Camuzat">T. Camuzat</name><affiliation><nlm:aff id="Aff104">Montpellier, Région Languedoc Roussillon France</nlm:aff></affiliation></author><author><name sortKey="Cardona, V" sort="Cardona, V" uniqKey="Cardona V" first="V." last="Cardona">V. Cardona</name><affiliation><nlm:aff id="Aff105">S. Allergologia, S. Medicina Interna, Hospital Vall d’Hebron, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Carreiro Martins, P" sort="Carreiro Martins, P" uniqKey="Carreiro Martins P" first="P." last="Carreiro-Martins">P. Carreiro-Martins</name><affiliation><nlm:aff id="Aff106">CEDOC, Respiratory Research Group, Nova Medical School, Campo dos Martires da Patria, Lisbon, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff107">Serviço de Imunoalergologia, Centro Hospitalar de Lisboa Central, EPE, Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Carriazo, A M" sort="Carriazo, A M" uniqKey="Carriazo A" first="A. M." last="Carriazo">A. M. Carriazo</name><affiliation><nlm:aff id="Aff108">Regional Ministry of Health of Andalusia, Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Carlsen, K H" sort="Carlsen, K H" uniqKey="Carlsen K" first="K. H." last="Carlsen">K. H. Carlsen</name><affiliation><nlm:aff id="Aff109">Department of Paediatrics, Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="Aff110">University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Carr, W" sort="Carr, W" uniqKey="Carr W" first="W." last="Carr">W. Carr</name><affiliation><nlm:aff id="Aff111">Allergy and Asthma Associates of Southern California, Mission Viejo, CA USA</nlm:aff></affiliation></author><author><name sortKey="Cepeda Sarabia, A M" sort="Cepeda Sarabia, A M" uniqKey="Cepeda Sarabia A" first="A. M." last="Cepeda Sarabia">A. M. Cepeda Sarabia</name><affiliation><nlm:aff id="Aff112">Allergy and Immunology Laboratory, Metropolitan University, Simon Bolivar University, Barranquilla, Colombia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff113">SLaai, Sociedad Latinoamericana de Allergia, Asma e Immunologia, Cartagena, Colombia</nlm:aff></affiliation></author><author><name sortKey="Cesari, M" sort="Cesari, M" uniqKey="Cesari M" first="M." last="Cesari">M. Cesari</name><affiliation><nlm:aff id="Aff114">Gérontopôle de Toulouse, 31059 Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Chatzi, L" sort="Chatzi, L" uniqKey="Chatzi L" first="L." last="Chatzi">L. Chatzi</name><affiliation><nlm:aff id="Aff115">Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete Greece</nlm:aff></affiliation></author><author><name sortKey="Chiron, R" sort="Chiron, R" uniqKey="Chiron R" first="R." last="Chiron">R. Chiron</name><affiliation><nlm:aff id="Aff13">Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Chivato, T" sort="Chivato, T" uniqKey="Chivato T" first="T." last="Chivato">T. Chivato</name><affiliation><nlm:aff id="Aff116">School of Medicine, University CEU San Pablo, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Chkhartishvili, E" sort="Chkhartishvili, E" uniqKey="Chkhartishvili E" first="E." last="Chkhartishvili">E. Chkhartishvili</name><affiliation><nlm:aff id="Aff117">Chachava Clinic, David Tvildiani Medical University-AIETI Medical School, Grigol Robakidze University, Tbilisi, Georgia</nlm:aff></affiliation></author><author><name sortKey="Chuchalin, A G" sort="Chuchalin, A G" uniqKey="Chuchalin A" first="A. G." last="Chuchalin">A. G. Chuchalin</name><affiliation><nlm:aff id="Aff118">Pulmonolory Research Institute FMBA, Moscow, Russia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff119">GARD Executive Committee, Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Chung, K F" sort="Chung, K F" uniqKey="Chung K" first="K. F." last="Chung">K. F. Chung</name><affiliation><nlm:aff id="Aff103">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Ciprandi, G" sort="Ciprandi, G" uniqKey="Ciprandi G" first="G." last="Ciprandi">G. Ciprandi</name><affiliation><nlm:aff id="Aff120">Medicine Department, IRCCS-Azienda Ospedaliera Universitaria San Martino, Genoa, Italy</nlm:aff></affiliation></author><author><name sortKey="De Sousa, J Correia" sort="De Sousa, J Correia" uniqKey="De Sousa J" first="J. Correia" last="De Sousa">J. Correia De Sousa</name><affiliation><nlm:aff id="Aff121">ICVS/3B’s-PT Government Associate Laboratory, Life and Health Sciences, Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal</nlm:aff></affiliation></author><author><name sortKey="Cox, L" sort="Cox, L" uniqKey="Cox L" first="L." last="Cox">L. Cox</name><affiliation><nlm:aff id="Aff122">Department of Medicine, Nova Southeastern University, Davie, FL USA</nlm:aff></affiliation></author><author><name sortKey="Crooks, G" sort="Crooks, G" uniqKey="Crooks G" first="G." last="Crooks">G. Crooks</name><affiliation><nlm:aff id="Aff123">EIP on AHA, European Innovation Partnership on Active and Healthy Ageing, Reference Site, Scottish Centre for Telehealth and Telecare, NHS 24, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Custovic, A" sort="Custovic, A" uniqKey="Custovic A" first="A." last="Custovic">A. Custovic</name><affiliation><nlm:aff id="Aff124">Department of Pediatric, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Dahlen, S E" sort="Dahlen, S E" uniqKey="Dahlen S" first="S. E." last="Dahlen">S. E. Dahlen</name><affiliation><nlm:aff id="Aff125">The Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darsow, U" sort="Darsow, U" uniqKey="Darsow U" first="U." last="Darsow">U. Darsow</name><affiliation><nlm:aff id="Aff126">Department of Dermatology and Allergy, Technische Universität München, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff127">ZAUM-Center for Allergy and Environment, Helmholtz Center Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Dedeu, T" sort="Dedeu, T" uniqKey="Dedeu T" first="T." last="Dedeu">T. Dedeu</name><affiliation><nlm:aff id="Aff128">AQuAS, Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff129">EUREGHA, European Regional and Local Health Association, Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Deleanu, D" sort="Deleanu, D" uniqKey="Deleanu D" first="D." last="Deleanu">D. Deleanu</name><affiliation><nlm:aff id="Aff130">Allergology and Immunology Discipline, “Luliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania</nlm:aff></affiliation></author><author><name sortKey="Denburg, J A" sort="Denburg, J A" uniqKey="Denburg J" first="J. A." last="Denburg">J. A. Denburg</name><affiliation><nlm:aff id="Aff131">Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON Canada</nlm:aff></affiliation></author><author><name sortKey="De Vries, G" sort="De Vries, G" uniqKey="De Vries G" first="G." last="De Vries">G. De Vries</name><affiliation><nlm:aff id="Aff132">Peercode DV, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Didier, A" sort="Didier, A" uniqKey="Didier A" first="A." last="Didier">A. Didier</name><affiliation><nlm:aff id="Aff133">Respiratory Diseases Department, Rangueil-Larrey Hospital, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Dinh Xuan, A T" sort="Dinh Xuan, A T" uniqKey="Dinh Xuan A" first="A. T." last="Dinh-Xuan">A. T. Dinh-Xuan</name><affiliation><nlm:aff id="Aff134">Service de Physiologie Respiratoire, Hôpital Cochin, Université Paris-Descartes, Assistance Publique-Hôpitaux de Paris, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Dokic, D" sort="Dokic, D" uniqKey="Dokic D" first="D." last="Dokic">D. Dokic</name><affiliation><nlm:aff id="Aff135">University Clinic of Pulmology and Allergy, Medical Faculty, Ss Cyril and Methodius University, Skopje, Republic of Macedonia</nlm:aff></affiliation></author><author><name sortKey="Douagui, H" sort="Douagui, H" uniqKey="Douagui H" first="H." last="Douagui">H. Douagui</name><affiliation><nlm:aff id="Aff136">Service de Pneumo-Allergologie, Centre Hospitalo-Universitaire de Béni-Messous, Algers, Algeria</nlm:aff></affiliation></author><author><name sortKey="Dray, G" sort="Dray, G" uniqKey="Dray G" first="G." last="Dray">G. Dray</name><affiliation><nlm:aff id="Aff137">Ecole des Mines, Alès, France</nlm:aff></affiliation></author><author><name sortKey="Dubakiene, R" sort="Dubakiene, R" uniqKey="Dubakiene R" first="R." last="Dubakiene">R. Dubakiene</name><affiliation><nlm:aff id="Aff138">Medical Faculty, Vilnius University, Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Durham, S R" sort="Durham, S R" uniqKey="Durham S" first="S. R." last="Durham">S. R. Durham</name><affiliation><nlm:aff id="Aff139">Allergy and Clinical Immunology Section, National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Du Toit, G" sort="Du Toit, G" uniqKey="Du Toit G" first="G." last="Du Toit">G. Du Toit</name><affiliation><nlm:aff id="Aff140">Guy’s and St Thomas’ NHS Trust, Kings College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Dykewicz, M S" sort="Dykewicz, M S" uniqKey="Dykewicz M" first="M. S." last="Dykewicz">M. S. Dykewicz</name><affiliation><nlm:aff id="Aff141">Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, MO USA</nlm:aff></affiliation></author><author><name sortKey="Eklund, P" sort="Eklund, P" uniqKey="Eklund P" first="P." last="Eklund">P. Eklund</name><affiliation><nlm:aff id="Aff142">Computing Science Department, Umeå University, Umeå, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="Aff143">Four Computing Oy, Halikko, Finland</nlm:aff></affiliation></author><author><name sortKey="El Gamal, Y" sort="El Gamal, Y" uniqKey="El Gamal Y" first="Y." last="El-Gamal">Y. El-Gamal</name><affiliation><nlm:aff id="Aff144">Pediatric Allergy and Immunology Unit, Ain Shams University, Cairo, Egypt</nlm:aff></affiliation></author><author><name sortKey="Ellers, E" sort="Ellers, E" uniqKey="Ellers E" first="E." last="Ellers">E. Ellers</name><affiliation><nlm:aff id="Aff10">Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Emuzyte, R" sort="Emuzyte, R" uniqKey="Emuzyte R" first="R." last="Emuzyte">R. Emuzyte</name><affiliation><nlm:aff id="Aff56">Clinic of Children’s Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania</nlm:aff></affiliation><affiliation><nlm:aff id="Aff57">Public Health Institute, Vilnius University, Vilnius, Lithuania</nlm:aff></affiliation><affiliation><nlm:aff id="Aff58">European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Farrell, J" sort="Farrell, J" uniqKey="Farrell J" first="J." last="Farrell">J. Farrell</name><affiliation><nlm:aff id="Aff145">Department of Health, Social Services and Public Safety, Belfast, Northern Ireland, UK</nlm:aff></affiliation></author><author><name sortKey="Fink Wagner, A" sort="Fink Wagner, A" uniqKey="Fink Wagner A" first="A." last="Fink Wagner">A. Fink Wagner</name><affiliation><nlm:aff id="Aff146">Global Allergy and Asthma Platform GAAPP, Altgasse 8-10, 1130 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Fiocchi, A" sort="Fiocchi, A" uniqKey="Fiocchi A" first="A." last="Fiocchi">A. Fiocchi</name><affiliation><nlm:aff id="Aff147">Division of Allergy, Department of Pediatric Medicine, The Bambino Gesù Children’s Research Hospital Holy See, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Fletcher, M" sort="Fletcher, M" uniqKey="Fletcher M" first="M." last="Fletcher">M. Fletcher</name><affiliation><nlm:aff id="Aff148">Education for Health, Warwick, UK</nlm:aff></affiliation></author><author><name sortKey="Forastiere, F" sort="Forastiere, F" uniqKey="Forastiere F" first="F." last="Forastiere">F. Forastiere</name><affiliation><nlm:aff id="Aff149">Department of Epidemiology, Regional Health Service Lazio Region, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Gaga, M" sort="Gaga, M" uniqKey="Gaga M" first="M." last="Gaga">M. Gaga</name><affiliation><nlm:aff id="Aff150">Athens Chest Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Gamkrelidze, A" sort="Gamkrelidze, A" uniqKey="Gamkrelidze A" first="A." last="Gamkrelidze">A. Gamkrelidze</name><affiliation><nlm:aff id="Aff151">National Center for Disease Control and Public Health of Georgia, Tbilisi, Georgia</nlm:aff></affiliation></author><author><name sortKey="Gemicio Lu, B" sort="Gemicio Lu, B" uniqKey="Gemicio Lu B" first="B." last="Gemicio Lu">B. Gemicio Lu</name><affiliation><nlm:aff id="Aff152">Department of Pulmonary Diseases, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey</nlm:aff></affiliation></author><author><name sortKey="Gereda, J E" sort="Gereda, J E" uniqKey="Gereda J" first="J. E." last="Gereda">J. E. Gereda</name><affiliation><nlm:aff id="Aff153">Allergy and Immunology Division, Clinica Ricardo Palma, Lima, Peru</nlm:aff></affiliation></author><author><name sortKey="Van Wick, R Gerth" sort="Van Wick, R Gerth" uniqKey="Van Wick R" first="R. Gerth" last="Van Wick">R. Gerth Van Wick</name><affiliation><nlm:aff id="Aff154">Section of Allergology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Diaz, S" sort="Gonzalez Diaz, S" uniqKey="Gonzalez Diaz S" first="S." last="González Diaz">S. González Diaz</name><affiliation><nlm:aff id="Aff155">Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Mexico</nlm:aff></affiliation></author><author><name sortKey="Grisle, I" sort="Grisle, I" uniqKey="Grisle I" first="I." last="Grisle">I. Grisle</name><affiliation><nlm:aff id="Aff156">Center of Tuberculosis and Lung Diseases, Latvian Association of Allergists, Riga, Latvia</nlm:aff></affiliation></author><author><name sortKey="Grouse, L" sort="Grouse, L" uniqKey="Grouse L" first="L." last="Grouse">L. Grouse</name><affiliation><nlm:aff id="Aff157">Faculty of the Department of Neurology, University of Washington School of Medicine, Seattle, WA USA</nlm:aff></affiliation></author><author><name sortKey="Gutter, Z" sort="Gutter, Z" uniqKey="Gutter Z" first="Z." last="Gutter">Z. Gutter</name><affiliation><nlm:aff id="Aff158">National eHealth Centre, University Hospital Olomouc, Olomouc, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Guzman, M A" sort="Guzman, M A" uniqKey="Guzman M" first="M. A." last="Guzmán">M. A. Guzmán</name><affiliation><nlm:aff id="Aff159">Immunology and Allergy Division Clinical Hospital, University of Chile, Santiago, Chile</nlm:aff></affiliation></author><author><name sortKey="Hellquist Dahl, B" sort="Hellquist Dahl, B" uniqKey="Hellquist Dahl B" first="B." last="Hellquist-Dahl">B. Hellquist-Dahl</name><affiliation><nlm:aff id="Aff160">Department of Respiratory Diseases, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Heinrich, J" sort="Heinrich, J" uniqKey="Heinrich J" first="J." last="Heinrich">J. Heinrich</name><affiliation><nlm:aff id="Aff161">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Horak, F" sort="Horak, F" uniqKey="Horak F" first="F." last="Horak">F. Horak</name><affiliation><nlm:aff id="Aff162">Vienna Challenge Chamber, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Hourihane, J O B" sort="Hourihane, J O B" uniqKey="Hourihane J" first="J. O B." last="Hourihane">J. O B. Hourihane</name><affiliation><nlm:aff id="Aff163">Department of Paediatrics and Child Health, University College Cork, Cork, Ireland</nlm:aff></affiliation></author><author><name sortKey="Humbert, M" sort="Humbert, M" uniqKey="Humbert M" first="M." last="Humbert">M. Humbert</name><affiliation><nlm:aff id="Aff164">Université Paris-Sud, Le Kremlin Bicêtre, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff165">Service de Pneumologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff166">Inserm UMR_S999, Le Kremlin Bicêtre, France</nlm:aff></affiliation></author><author><name sortKey="Hyland, M" sort="Hyland, M" uniqKey="Hyland M" first="M." last="Hyland">M. Hyland</name><affiliation><nlm:aff id="Aff167">School of Psychology, Plymouth University, Plymouth, UK</nlm:aff></affiliation></author><author><name sortKey="Iaccarino, G" sort="Iaccarino, G" uniqKey="Iaccarino G" first="G." last="Iaccarino">G. Iaccarino</name><affiliation><nlm:aff id="Aff168">Department of Medicine and Surgery, University of Salerno, Baronissi, Italy</nlm:aff></affiliation></author><author><name sortKey="Jares, E J" sort="Jares, E J" uniqKey="Jares E" first="E. J." last="Jares">E. J. Jares</name><affiliation><nlm:aff id="Aff169">Libra Foundation, Buenos Aires, Argentina</nlm:aff></affiliation></author><author><name sortKey="Jeandel, C" sort="Jeandel, C" uniqKey="Jeandel C" first="C." last="Jeandel">C. Jeandel</name><affiliation><nlm:aff id="Aff2">MACVIA-France, Contre les MAladies Chroniques pour un VIeillissement Actif en France, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff87">Department of Geriatrics, Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Johnston, S L" sort="Johnston, S L" uniqKey="Johnston S" first="S. L." last="Johnston">S. L. Johnston</name><affiliation><nlm:aff id="Aff170">Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff171">MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK</nlm:aff></affiliation></author><author><name sortKey="Joos, G" sort="Joos, G" uniqKey="Joos G" first="G." last="Joos">G. Joos</name><affiliation><nlm:aff id="Aff172">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Jonquet, O" sort="Jonquet, O" uniqKey="Jonquet O" first="O." last="Jonquet">O. Jonquet</name><affiliation><nlm:aff id="Aff173">Medical Commission, Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Jung, K S" sort="Jung, K S" uniqKey="Jung K" first="K. S." last="Jung">K. S. Jung</name><affiliation><nlm:aff id="Aff174">Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Gyeonggi-do South Korea</nlm:aff></affiliation></author><author><name sortKey="Jutel, M" sort="Jutel, M" uniqKey="Jutel M" first="M." last="Jutel">M. Jutel</name><affiliation><nlm:aff id="Aff175">Department of Clinical Immunology, Wrocław Medical University, Wrocław, Poland</nlm:aff></affiliation></author><author><name sortKey="Kaidashev, I" sort="Kaidashev, I" uniqKey="Kaidashev I" first="I." last="Kaidashev">I. Kaidashev</name><affiliation><nlm:aff id="Aff176">Ukrainian Medical Stomatological Academy, Poltava, Ukraine</nlm:aff></affiliation></author><author><name sortKey="Khaitov, M" sort="Khaitov, M" uniqKey="Khaitov M" first="M." last="Khaitov">M. Khaitov</name><affiliation><nlm:aff id="Aff177">Laboratory of Molecular Immunology, National Research Center, Institute of Immunology, Federal Medicobiological Agency, Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Kalayci, O" sort="Kalayci, O" uniqKey="Kalayci O" first="O." last="Kalayci">O. Kalayci</name><affiliation><nlm:aff id="Aff178">Pediatric Allergy and Asthma Unit, School of Medicine, Hacettepe University, Ankara, Turkey</nlm:aff></affiliation></author><author><name sortKey="Kalyoncu, A F" sort="Kalyoncu, A F" uniqKey="Kalyoncu A" first="A. F." last="Kalyoncu">A. F. Kalyoncu</name><affiliation><nlm:aff id="Aff179">Immunology and Allergy Division, Department of Chest Diseases, School of Medicine, Hacettepe University, Ankara, Turkey</nlm:aff></affiliation></author><author><name sortKey="Kardas, P" sort="Kardas, P" uniqKey="Kardas P" first="P." last="Kardas">P. Kardas</name><affiliation><nlm:aff id="Aff180">First Department of Family Medicine, Medical University of Lodz, Lodz, Poland</nlm:aff></affiliation></author><author><name sortKey="Keith, P K" sort="Keith, P K" uniqKey="Keith P" first="P. K." last="Keith">P. K. Keith</name><affiliation><nlm:aff id="Aff181">Department of Medicine, McMaster University, Health Sciences Centre 3V47, 1280 Main Street West, Hamilton, ON Canada</nlm:aff></affiliation></author><author><name sortKey="Kerkhof, M" sort="Kerkhof, M" uniqKey="Kerkhof M" first="M." last="Kerkhof">M. Kerkhof</name><affiliation><nlm:aff id="Aff182">Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kerstjens, H A M" sort="Kerstjens, H A M" uniqKey="Kerstjens H" first="H. A. M." last="Kerstjens">H. A. M. Kerstjens</name><affiliation><nlm:aff id="Aff182">Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Khaltaev, N" sort="Khaltaev, N" uniqKey="Khaltaev N" first="N." last="Khaltaev">N. Khaltaev</name><affiliation><nlm:aff id="Aff183">GARD, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M." last="Kogevinas">M. Kogevinas</name><affiliation><nlm:aff id="Aff69">Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff70">IMIM (Hospital del Mar Research Institute), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff71">CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff72">Universitat Pompeu Fabra (UPF), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Kolek, V" sort="Kolek, V" uniqKey="Kolek V" first="V." last="Kolek">V. Kolek</name><affiliation><nlm:aff id="Aff184">Department of Respiratory Medicine, Faculty of Medicine and Dentistry, University Hospital Olomouc, Olomouc, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Koppelman, G H" sort="Koppelman, G H" uniqKey="Koppelman G" first="G. H." last="Koppelman">G. H. Koppelman</name><affiliation><nlm:aff id="Aff185">Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children’s Hospital, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kowalski, M L" sort="Kowalski, M L" uniqKey="Kowalski M" first="M. L." last="Kowalski">M. L. Kowalski</name><affiliation><nlm:aff id="Aff186">Department of Immunology, Rheumatology and Allergy and HARC, Medical University of Lodz, Lodz, Poland</nlm:aff></affiliation></author><author><name sortKey="Kuitunen, M" sort="Kuitunen, M" uniqKey="Kuitunen M" first="M." last="Kuitunen">M. Kuitunen</name><affiliation><nlm:aff id="Aff187">Children’s Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kull, I" sort="Kull, I" uniqKey="Kull I" first="I." last="Kull">I. Kull</name><affiliation><nlm:aff id="Aff62">Sachs’ Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="Aff63">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kvedariene, V" sort="Kvedariene, V" uniqKey="Kvedariene V" first="V." last="Kvedariene">V. Kvedariene</name><affiliation><nlm:aff id="Aff188">Clinic of Infectious, Chest Diseases, Dermatology and Allergology, Vilnius University, Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Lambrecht, B" sort="Lambrecht, B" uniqKey="Lambrecht B" first="B." last="Lambrecht">B. Lambrecht</name><affiliation><nlm:aff id="Aff189">VIB Inflammation Research Center, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Lau, S" sort="Lau, S" uniqKey="Lau S" first="S." last="Lau">S. Lau</name><affiliation><nlm:aff id="Aff190">Department for Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Laune, D" sort="Laune, D" uniqKey="Laune D" first="D." last="Laune">D. Laune</name><affiliation><nlm:aff id="Aff73">Kyomed, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Le, L T T" sort="Le, L T T" uniqKey="Le L" first="L. T. T." last="Le">L. T. T. Le</name><affiliation><nlm:aff id="Aff191">University of Medicine and Pharmacy, Hochiminh City, Vietnam</nlm:aff></affiliation></author><author><name sortKey="Lieberman, P" sort="Lieberman, P" uniqKey="Lieberman P" first="P." last="Lieberman">P. Lieberman</name><affiliation><nlm:aff id="Aff192">Divisions of Allergy and Immunology, Department of Internal Medicine and Pediatrics, University of Tennessee College of Medicine, Germantown, TN USA</nlm:aff></affiliation></author><author><name sortKey="Lipworth, B" sort="Lipworth, B" uniqKey="Lipworth B" first="B." last="Lipworth">B. Lipworth</name><affiliation><nlm:aff id="Aff193">Scottish Centre for Respiratory Research, Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, UK</nlm:aff></affiliation></author><author><name sortKey="Li, J" sort="Li, J" uniqKey="Li J" first="J." last="Li">J. Li</name><affiliation><nlm:aff id="Aff194">State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Lodrup Carlsen, K C" sort="Lodrup Carlsen, K C" uniqKey="Lodrup Carlsen K" first="K. C." last="Lodrup Carlsen">K. C. Lodrup Carlsen</name><affiliation><nlm:aff id="Aff109">Department of Paediatrics, Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="Aff195">Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Louis, R" sort="Louis, R" uniqKey="Louis R" first="R." last="Louis">R. Louis</name><affiliation><nlm:aff id="Aff196">Department of Pulmonary Medicine, CHU Sart-Tilman, Liege, Belgium</nlm:aff></affiliation></author><author><name sortKey="Lupinek, C" sort="Lupinek, C" uniqKey="Lupinek C" first="C." last="Lupinek">C. Lupinek</name><affiliation><nlm:aff id="Aff197">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Macnee, W" sort="Macnee, W" uniqKey="Macnee W" first="W." last="Macnee">W. Macnee</name><affiliation><nlm:aff id="Aff198">The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Magar, Y" sort="Magar, Y" uniqKey="Magar Y" first="Y." last="Magar">Y. Magar</name><affiliation><nlm:aff id="Aff199">Service de Pneumo-allergologie, Hôpital Saint-Joseph, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Magnan, A" sort="Magnan, A" uniqKey="Magnan A" first="A." last="Magnan">A. Magnan</name><affiliation><nlm:aff id="Aff200">Service de Pneumologie, UMR INSERM, UMR1087 and CNR 6291, l’institut du Thorax, University of Nantes, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Mahboub, B" sort="Mahboub, B" uniqKey="Mahboub B" first="B." last="Mahboub">B. Mahboub</name><affiliation><nlm:aff id="Aff201">Department of Pulmonary Medicine, Rashid Hospital, Dubai, UAE</nlm:aff></affiliation></author><author><name sortKey="Maier, D" sort="Maier, D" uniqKey="Maier D" first="D." last="Maier">D. Maier</name><affiliation><nlm:aff id="Aff202">Biomax Informatics AG, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Majer, I" sort="Majer, I" uniqKey="Majer I" first="I." last="Majer">I. Majer</name><affiliation><nlm:aff id="Aff203">Department of Respiratory Medicine, University of Bratislava, Bratislava, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Malva, J" sort="Malva, J" uniqKey="Malva J" first="J." last="Malva">J. Malva</name><affiliation><nlm:aff id="Aff204">Institute of Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff205">Ageing@Coimbra EIP-AHA Reference Site, Coimbra, Portugal</nlm:aff></affiliation></author><author><name sortKey="Manning, P" sort="Manning, P" uniqKey="Manning P" first="P." last="Manning">P. Manning</name><affiliation><nlm:aff id="Aff206">Department of Medicine (RCSI), Bon Secours Hospital, Glasnevin, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="De Manuel Keenoy, E" sort="De Manuel Keenoy, E" uniqKey="De Manuel Keenoy E" first="E." last="De Manuel Keenoy">E. De Manuel Keenoy</name><affiliation><nlm:aff id="Aff207">Kronikgune, Basque Region, Spain</nlm:aff></affiliation></author><author><name sortKey="Marshall, G D" sort="Marshall, G D" uniqKey="Marshall G" first="G. D." last="Marshall">G. D. Marshall</name><affiliation><nlm:aff id="Aff208">Laboratory of Behavioral Immunology Research, Division of Clinical Immunology and Allergy, The University of Mississippi Medical Center, Jackson, MS USA</nlm:aff></affiliation></author><author><name sortKey="Masjedi, M R" sort="Masjedi, M R" uniqKey="Masjedi M" first="M. R." last="Masjedi">M. R. Masjedi</name><affiliation><nlm:aff id="Aff209">Tobacco Control Research Centre, Iranian Anti Tobacco Association, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Mathieu Dupas, E" sort="Mathieu Dupas, E" uniqKey="Mathieu Dupas E" first="E." last="Mathieu-Dupas">E. Mathieu-Dupas</name><affiliation><nlm:aff id="Aff73">Kyomed, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Maurer, M" sort="Maurer, M" uniqKey="Maurer M" first="M." last="Maurer">M. Maurer</name><affiliation><nlm:aff id="Aff7">Allergy-Centre-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Mavale Manuel, S" sort="Mavale Manuel, S" uniqKey="Mavale Manuel S" first="S." last="Mavale-Manuel">S. Mavale-Manuel</name><affiliation><nlm:aff id="Aff210">Department of Paediatrics, Maputo Central Hospital, Maputo, Mozambique</nlm:aff></affiliation></author><author><name sortKey="Melen, E" sort="Melen, E" uniqKey="Melen E" first="E." last="Melén">E. Melén</name><affiliation><nlm:aff id="Aff62">Sachs’ Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="Aff63">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Melo Gomes, E" sort="Melo Gomes, E" uniqKey="Melo Gomes E" first="E." last="Melo-Gomes">E. Melo-Gomes</name><affiliation><nlm:aff id="Aff78">Faculdade de Medicina de Lisboa, Portuguese National Programme for Respiratory Diseases (PNDR), Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Meltzer, E O" sort="Meltzer, E O" uniqKey="Meltzer E" first="E. O." last="Meltzer">E. O. Meltzer</name><affiliation><nlm:aff id="Aff211">Allergy and Asthma Medical Group and Research Center, San Diego, CA USA</nlm:aff></affiliation></author><author><name sortKey="Mercier, J" sort="Mercier, J" uniqKey="Mercier J" first="J." last="Mercier">J. Mercier</name><affiliation><nlm:aff id="Aff212">Department of Physiology, CHRU, PhyMedExp, INSERM U1046, CNRS UMR 9214, University Montpellier, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Merk, H" sort="Merk, H" uniqKey="Merk H" first="H." last="Merk">H. Merk</name><affiliation><nlm:aff id="Aff213">Hautklinik - Klinik für Dermatologie & Allergologie, Universitätsklinikum der RWTH Aachen, Aachen, Germany</nlm:aff></affiliation></author><author><name sortKey="Miculinic, N" sort="Miculinic, N" uniqKey="Miculinic N" first="N." last="Miculinic">N. Miculinic</name><affiliation><nlm:aff id="Aff214">Croatian Pulmonary Society, Zagreb, Croatia</nlm:aff></affiliation></author><author><name sortKey="Mihaltan, F" sort="Mihaltan, F" uniqKey="Mihaltan F" first="F." last="Mihaltan">F. Mihaltan</name><affiliation><nlm:aff id="Aff215">National Institute of Pneumology M. Nasta, Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Milenkovic, B" sort="Milenkovic, B" uniqKey="Milenkovic B" first="B." last="Milenkovic">B. Milenkovic</name><affiliation><nlm:aff id="Aff216">Faculty of Medicine, University of Belgrade, Belgrade, Serbia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff217">Serbian Association for Asthma and COPD, Belgrade, Serbia</nlm:aff></affiliation></author><author><name sortKey="Millot Keurinck, J" sort="Millot Keurinck, J" uniqKey="Millot Keurinck J" first="J." last="Millot-Keurinck">J. Millot-Keurinck</name><affiliation><nlm:aff id="Aff218">Caisse d’assurance retraite et de la santé au travail du Languedoc-Roussillon (CARSAT-LR), Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Mohammad, Y" sort="Mohammad, Y" uniqKey="Mohammad Y" first="Y." last="Mohammad">Y. Mohammad</name><affiliation><nlm:aff id="Aff219">National Center for Research in Chronic Respiratory Diseases, Tishreen University School of Medicine, Latakia, Syria</nlm:aff></affiliation></author><author><name sortKey="Momas, I" sort="Momas, I" uniqKey="Momas I" first="I." last="Momas">I. Momas</name><affiliation><nlm:aff id="Aff220">Department of Public Health and Health Products, EA 4064, Paris Descartes University-Sorbonne Paris Cité, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff221">Paris Municipal Department of Social Action, Childhood, and Health, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mosges, R" sort="Mosges, R" uniqKey="Mosges R" first="R." last="Mösges">R. Mösges</name><affiliation><nlm:aff id="Aff222">Institute of Medical Statistics, Informatics and Epidemiology, Medical Faculty, University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Muraro, A" sort="Muraro, A" uniqKey="Muraro A" first="A." last="Muraro">A. Muraro</name><affiliation><nlm:aff id="Aff223">Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Namazova Baranova, L" sort="Namazova Baranova, L" uniqKey="Namazova Baranova L" first="L." last="Namazova-Baranova">L. Namazova-Baranova</name><affiliation><nlm:aff id="Aff224">Scientific Centre of Children’s Health Under the Russian Academy of Medical Sciences, Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Nadif, R" sort="Nadif, R" uniqKey="Nadif R" first="R." last="Nadif">R. Nadif</name><affiliation><nlm:aff id="Aff3">INSERM, U1168, Ageing and Chronic Diseases Epidemiological and Public Health Approaches, 94800 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Neffen, H" sort="Neffen, H" uniqKey="Neffen H" first="H." last="Neffen">H. Neffen</name><affiliation><nlm:aff id="Aff225">Hospital de Niños Orlando Alassia, Santa Fe, Argentina</nlm:aff></affiliation></author><author><name sortKey="Nekam, K" sort="Nekam, K" uniqKey="Nekam K" first="K." last="Nekam">K. Nekam</name><affiliation><nlm:aff id="Aff226">Hospital of the Hospitaller Brothers in Buda, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Nieto, A" sort="Nieto, A" uniqKey="Nieto A" first="A." last="Nieto">A. Nieto</name><affiliation><nlm:aff id="Aff227">Neumología y Alergología Infantil, Hospital La Fe, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Niggemann, B" sort="Niggemann, B" uniqKey="Niggemann B" first="B." last="Niggemann">B. Niggemann</name><affiliation><nlm:aff id="Aff190">Department for Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Nogueira Silva, L" sort="Nogueira Silva, L" uniqKey="Nogueira Silva L" first="L." last="Nogueira-Silva">L. Nogueira-Silva</name><affiliation><nlm:aff id="Aff24">Center for Research in Health Technologies and Information Systems - CINTESIS, Universidade do Porto, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff25">Allergy Unit, Instituto CUF Porto e Hospital CUF Porto, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff26">Health Information and Decision Sciences Department - CIDES, Faculdade de Medicina, Universidade do Porto, Rua Dr. Plácido da Costa, s/n, 4200-450 Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff228">Department of Internal Medicine, Centro Hospitalar Sao Joao, Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Nogues, M" sort="Nogues, M" uniqKey="Nogues M" first="M." last="Nogues">M. Nogues</name><affiliation><nlm:aff id="Aff2">MACVIA-France, Contre les MAladies Chroniques pour un VIeillissement Actif en France, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff218">Caisse d’assurance retraite et de la santé au travail du Languedoc-Roussillon (CARSAT-LR), Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Nyembue, T D" sort="Nyembue, T D" uniqKey="Nyembue T" first="T. D." last="Nyembue">T. D. Nyembue</name><affiliation><nlm:aff id="Aff229">ENT Department, University Hospital of Kinshasa, Kinshasa, Congo</nlm:aff></affiliation></author><author><name sortKey="Ohta, K" sort="Ohta, K" uniqKey="Ohta K" first="K." last="Ohta">K. Ohta</name><affiliation><nlm:aff id="Aff230">National Hospital Organization, Tokyo National Hospital, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Okamoto, Y" sort="Okamoto, Y" uniqKey="Okamoto Y" first="Y." last="Okamoto">Y. Okamoto</name><affiliation><nlm:aff id="Aff231">Department of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan</nlm:aff></affiliation></author><author><name sortKey="Okubo, K" sort="Okubo, K" uniqKey="Okubo K" first="K." last="Okubo">K. Okubo</name><affiliation><nlm:aff id="Aff232">Department of Otolaryngology, Nippon Medical School, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Olive Elias, M" sort="Olive Elias, M" uniqKey="Olive Elias M" first="M." last="Olive-Elias">M. Olive-Elias</name><affiliation><nlm:aff id="Aff1">Montpellier University Hospital, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff28">Institute of Health Policy and Management IBMG, Erasmus University, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="Aff29">Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ouedraogo, S" sort="Ouedraogo, S" uniqKey="Ouedraogo S" first="S." last="Ouedraogo">S. Ouedraogo</name><affiliation><nlm:aff id="Aff233">Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle, Ouagadougou, Burkina Faso</nlm:aff></affiliation></author><author><name sortKey="Paggiaro, P" sort="Paggiaro, P" uniqKey="Paggiaro P" first="P." last="Paggiaro">P. Paggiaro</name><affiliation><nlm:aff id="Aff234">Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Pali Scholl, I" sort="Pali Scholl, I" uniqKey="Pali Scholl I" first="I." last="Pali-Schöll">I. Pali-Schöll</name><affiliation><nlm:aff id="Aff235">Department of Comparative Medicine, Messerli Research Institute of the University of Veterinary Medicine, Medical University, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Palkonen, S" sort="Palkonen, S" uniqKey="Palkonen S" first="S." last="Palkonen">S. Palkonen</name><affiliation><nlm:aff id="Aff20">EFA European Federation of Allergy and Airways Diseases Patients’ Associations, Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Panzner, P" sort="Panzner, P" uniqKey="Panzner P" first="P." last="Panzner">P. Panzner</name><affiliation><nlm:aff id="Aff236">Department of Immunology and Allergology, Faculty of Medicine and Faculty Hospital in Pilsen, Charles University in Prague, Pilsen, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Papi, A" sort="Papi, A" uniqKey="Papi A" first="A." last="Papi">A. Papi</name><affiliation><nlm:aff id="Aff237">Respiratory Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy</nlm:aff></affiliation></author><author><name sortKey="Park, H S" sort="Park, H S" uniqKey="Park H" first="H. S." last="Park">H. S. Park</name><affiliation><nlm:aff id="Aff238">Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea</nlm:aff></affiliation></author><author><name sortKey="Passalacqua, G" sort="Passalacqua, G" uniqKey="Passalacqua G" first="G." last="Passalacqua">G. Passalacqua</name><affiliation><nlm:aff id="Aff15">Asthma and Allergy Clinic, Humanitas University, Rozzano, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Pedersen, S" sort="Pedersen, S" uniqKey="Pedersen S" first="S." last="Pedersen">S. Pedersen</name><affiliation><nlm:aff id="Aff239">University of Southern Denmark, Kolding, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pereira, A M" sort="Pereira, A M" uniqKey="Pereira A" first="A. M." last="Pereira">A. M. Pereira</name><affiliation><nlm:aff id="Aff24">Center for Research in Health Technologies and Information Systems - CINTESIS, Universidade do Porto, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff25">Allergy Unit, Instituto CUF Porto e Hospital CUF Porto, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff26">Health Information and Decision Sciences Department - CIDES, Faculdade de Medicina, Universidade do Porto, Rua Dr. Plácido da Costa, s/n, 4200-450 Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="Aff240">Allergy Unit, CUF-Porto Hospital and Institute, Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Pfaar, O" sort="Pfaar, O" uniqKey="Pfaar O" first="O." last="Pfaar">O. Pfaar</name><affiliation><nlm:aff id="Aff34">Center for Rhinology and Allergology, Wiesbaden, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff241">Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Picard, R" sort="Picard, R" uniqKey="Picard R" first="R." last="Picard">R. Picard</name><affiliation><nlm:aff id="Aff242">Conseil Général de l’Economie, Ministère de l’Economie, de l’Industrie et du Numérique, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Pigearias, B" sort="Pigearias, B" uniqKey="Pigearias B" first="B." last="Pigearias">B. Pigearias</name><affiliation><nlm:aff id="Aff243">Société de Pneumologie de Langue Française, Espace francophone de Pneumologie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Pin, I" sort="Pin, I" uniqKey="Pin I" first="I." last="Pin">I. Pin</name><affiliation><nlm:aff id="Aff244">Département de pédiatrie, CHU de Grenoble, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Plavec, D" sort="Plavec, D" uniqKey="Plavec D" first="D." last="Plavec">D. Plavec</name><affiliation><nlm:aff id="Aff245">Children’s Hospital Srebrnjak, Zagreb, Croatia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff246">School of Medicine, University J.J. Strossmayer, Osijek, Croatia</nlm:aff></affiliation></author><author><name sortKey="Pohl, W" sort="Pohl, W" uniqKey="Pohl W" first="W." last="Pohl">W. Pohl</name><affiliation><nlm:aff id="Aff247">Karl Landsteiner Institute for Clinical and Experimental Pneumology, Hietzing Hospital, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Popov, T A" sort="Popov, T A" uniqKey="Popov T" first="T. A." last="Popov">T. A. Popov</name><affiliation><nlm:aff id="Aff248">Clinic of Allergy and Asthma, Medical University Sofia, Sofia, Bulgaria</nlm:aff></affiliation></author><author><name sortKey="Portejoie, F" sort="Portejoie, F" uniqKey="Portejoie F" first="F." last="Portejoie">F. Portejoie</name><affiliation><nlm:aff id="Aff2">MACVIA-France, Contre les MAladies Chroniques pour un VIeillissement Actif en France, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Postma, D" sort="Postma, D" uniqKey="Postma D" first="D." last="Postma">D. Postma</name><affiliation><nlm:aff id="Aff249">University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Poulsen, L K" sort="Poulsen, L K" uniqKey="Poulsen L" first="L. K." last="Poulsen">L. K. Poulsen</name><affiliation><nlm:aff id="Aff250">Laboratory of Medical Allergology, Allergy Clinic, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Price, D" sort="Price, D" uniqKey="Price D" first="D." last="Price">D. Price</name><affiliation><nlm:aff id="Aff251">Academic Centre of Primary Care, University of Aberdeen, Aberdeen, Scotland, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff252">Research in Real-Life, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Rabe, K F" sort="Rabe, K F" uniqKey="Rabe K" first="K. F." last="Rabe">K. F. Rabe</name><affiliation><nlm:aff id="Aff253">LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research (DZL), Grosshansdorf, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff254">Department of Medicine, Christian Albrechts University, Airway Research Center North, German Center for Lung Research (DZL), Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Raciborski, F" sort="Raciborski, F" uniqKey="Raciborski F" first="F." last="Raciborski">F. Raciborski</name><affiliation><nlm:aff id="Aff49">Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Roberts, G" sort="Roberts, G" uniqKey="Roberts G" first="G." last="Roberts">G. Roberts</name><affiliation><nlm:aff id="Aff255">NHS Foundation Trust, University Hospitals of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Robalo Cordeiro, C" sort="Robalo Cordeiro, C" uniqKey="Robalo Cordeiro C" first="C." last="Robalo-Cordeiro">C. Robalo-Cordeiro</name><affiliation><nlm:aff id="Aff256">Centre of Pneumology, Coimbra University Hospital, Coimbra, Portugal</nlm:aff></affiliation></author><author><name sortKey="Rodenas, F" sort="Rodenas, F" uniqKey="Rodenas F" first="F." last="Rodenas">F. Rodenas</name><affiliation><nlm:aff id="Aff257">Polibienestar Research Institute, University of Valencia, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Rodriguez Ma As, L" sort="Rodriguez Ma As, L" uniqKey="Rodriguez Ma As L" first="L." last="Rodriguez-Ma As">L. Rodriguez-Ma As</name><affiliation><nlm:aff id="Aff258">Department of Geriatrics, Getafe University Hospital, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Rolland, C" sort="Rolland, C" uniqKey="Rolland C" first="C." last="Rolland">C. Rolland</name><affiliation><nlm:aff id="Aff259">Association Asthme et Allergie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Roman Rodriguez, M" sort="Roman Rodriguez, M" uniqKey="Roman Rodriguez M" first="M." last="Roman Rodriguez">M. Roman Rodriguez</name><affiliation><nlm:aff id="Aff260">Primary Care Respiratory Research Unit, Institutode Investigación Sanitaria de Palma IdisPa, Palma de Mallorca, Spain</nlm:aff></affiliation></author><author><name sortKey="Romano, A" sort="Romano, A" uniqKey="Romano A" first="A." last="Romano">A. Romano</name><affiliation><nlm:aff id="Aff261">Allergy Unit, Complesso Integrato Columbus, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Rosado Pinto, J" sort="Rosado Pinto, J" uniqKey="Rosado Pinto J" first="J." last="Rosado-Pinto">J. Rosado-Pinto</name><affiliation><nlm:aff id="Aff262">Serviço de Imunoalergologia, Hospital da Luz, Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Rosario, N" sort="Rosario, N" uniqKey="Rosario N" first="N." last="Rosario">N. Rosario</name><affiliation><nlm:aff id="Aff263">Hospital de Clinicas, University of Parana, Curitiba, Brazil</nlm:aff></affiliation></author><author><name sortKey="Rottem, M" sort="Rottem, M" uniqKey="Rottem M" first="M." last="Rottem">M. Rottem</name><affiliation><nlm:aff id="Aff264">Division of Allergy Asthma and Clinical Immunology, Emek Medical Center, Afula, Israel</nlm:aff></affiliation></author><author><name sortKey="Sanchez Borges, M" sort="Sanchez Borges, M" uniqKey="Sanchez Borges M" first="M." last="Sanchez-Borges">M. Sanchez-Borges</name><affiliation><nlm:aff id="Aff265">Allergy and Clinical Immunology Department, Centro Médico-Docente La Trinidad and Clínica El Avila, Caracas, Venezuela</nlm:aff></affiliation></author><author><name sortKey="Sastre Dominguez, J" sort="Sastre Dominguez, J" uniqKey="Sastre Dominguez J" first="J." last="Sastre-Dominguez">J. Sastre-Dominguez</name><affiliation><nlm:aff id="Aff266">Faculty of Medicine, Autononous University of Madrid, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Scadding, G K" sort="Scadding, G K" uniqKey="Scadding G" first="G. K." last="Scadding">G. K. Scadding</name><affiliation><nlm:aff id="Aff267">The Royal National TNE Hospital, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Scichilone, N" sort="Scichilone, N" uniqKey="Scichilone N" first="N." last="Scichilone">N. Scichilone</name><affiliation><nlm:aff id="Aff268">DIBIMIS, University of Palermo, Palermo, Italy</nlm:aff></affiliation></author><author><name sortKey="Schmid Grendelmeier, P" sort="Schmid Grendelmeier, P" uniqKey="Schmid Grendelmeier P" first="P." last="Schmid-Grendelmeier">P. Schmid-Grendelmeier</name><affiliation><nlm:aff id="Aff269">Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Serrano, E" sort="Serrano, E" uniqKey="Serrano E" first="E." last="Serrano">E. 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Williams</name><affiliation><nlm:aff id="Aff298">Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC USA</nlm:aff></affiliation></author><author><name sortKey="Williams, S" sort="Williams, S" uniqKey="Williams S" first="S." last="Williams">S. Williams</name><affiliation><nlm:aff id="Aff299">IPCRG, Aberdeen, Scotland, UK</nlm:aff></affiliation></author><author><name sortKey="Wilson, N" sort="Wilson, N" uniqKey="Wilson N" first="N." last="Wilson">N. Wilson</name><affiliation><nlm:aff id="Aff311">Northern Health Alliance, Newcastle, UK</nlm:aff></affiliation></author><author><name sortKey="Wright, J" sort="Wright, J" uniqKey="Wright J" first="J." last="Wright">J. Wright</name><affiliation><nlm:aff id="Aff300">Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK</nlm:aff></affiliation></author><author><name sortKey="Yawn, B P" sort="Yawn, B P" uniqKey="Yawn B" first="B. P." last="Yawn">B. P. Yawn</name><affiliation><nlm:aff id="Aff301">Department of Research, Olmsted Medical Center, Rochester, MN USA</nlm:aff></affiliation></author><author><name sortKey="Yiallouros, P K" sort="Yiallouros, P K" uniqKey="Yiallouros P" first="P. K." last="Yiallouros">P. K. Yiallouros</name><affiliation><nlm:aff id="Aff302">Medical School, University of Cyprus, Nicosia, Cyprus</nlm:aff></affiliation></author><author><name sortKey="Yusuf, O M" sort="Yusuf, O M" uniqKey="Yusuf O" first="O. M." last="Yusuf">O. M. Yusuf</name><affiliation><nlm:aff id="Aff303">The Allergy and Asthma Institute, Lahore, Pakistan</nlm:aff></affiliation></author><author><name sortKey="Zaidi, A" sort="Zaidi, A" uniqKey="Zaidi A" first="A." last="Zaidi">A. Zaidi</name><affiliation><nlm:aff id="Aff304">Social Sciences, University of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Zar, H J" sort="Zar, H J" uniqKey="Zar H" first="H. J." last="Zar">H. J. Zar</name><affiliation><nlm:aff id="Aff305">Department of Paediatrics and Child Health, Red Cross Children’s Hospital, University of Cape Town, Cape Town, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="Aff306">MRC Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Zernotti, M E" sort="Zernotti, M E" uniqKey="Zernotti M" first="M. E." last="Zernotti">M. E. Zernotti</name><affiliation><nlm:aff id="Aff307">Universidad Católica de Córdoba, Córdoba, Argentina</nlm:aff></affiliation></author><author><name sortKey="Zhang, L" sort="Zhang, L" uniqKey="Zhang L" first="L." last="Zhang">L. Zhang</name><affiliation><nlm:aff id="Aff308">Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Beijing, China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff309">Beijing Institute of Otolaryngology, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Zhong, N" sort="Zhong, N" uniqKey="Zhong N" first="N." last="Zhong">N. Zhong</name><affiliation><nlm:aff id="Aff194">State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Zidarn, M" sort="Zidarn, M" uniqKey="Zidarn M" first="M." last="Zidarn">M. Zidarn</name><affiliation><nlm:aff id="Aff310">University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia</nlm:aff></affiliation></author></analytic><series><title level="j">Clinical and Translational Allergy</title><idno type="eISSN">2045-7022</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA—disseminated and implemented in over 70 countries globally—is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (<italic>Contre les Maladies Chroniques pour un Vieillissement Actif</italic>)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bousquet, J" uniqKey="Bousquet J">J Bousquet</name></author><author><name sortKey="Van Cauwenberge, P" uniqKey="Van Cauwenberge P">P Van Cauwenberge</name></author><author><name sortKey="Khaltaev, N" uniqKey="Khaltaev N">N Khaltaev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shekelle, Pg" uniqKey="Shekelle P">PG Shekelle</name></author><author><name sortKey="Woolf, Sh" uniqKey="Woolf S">SH Woolf</name></author><author><name sortKey="Eccles, M" uniqKey="Eccles M">M Eccles</name></author><author><name sortKey="Grimshaw, J" uniqKey="Grimshaw J">J 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E.</given-names></name><address><email>mario.zernotti@gmail.com</email></address><xref ref-type="aff" rid="Aff307">307</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>L.</given-names></name><address><email>dr.luozhang@139.com</email></address><xref ref-type="aff" rid="Aff308">308</xref><xref ref-type="aff" rid="Aff309">309</xref></contrib><contrib contrib-type="author"><name><surname>Zhong</surname><given-names>N.</given-names></name><address><email>zgqiao@vip.163.com</email></address><xref ref-type="aff" rid="Aff194">194</xref></contrib><contrib contrib-type="author"><name><surname>Zidarn</surname><given-names>M.</given-names></name><address><email>mihaela.zidarn@klinika-golnik.si</email></address><xref ref-type="aff" rid="Aff310">310</xref></contrib><aff id="Aff1"><label>1</label>Montpellier University Hospital, Montpellier, France</aff><aff id="Aff2"><label>2</label>MACVIA-France, Contre les MAladies Chroniques pour un VIeillissement Actif en France, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France</aff><aff id="Aff3"><label>3</label>INSERM, U1168, Ageing and Chronic Diseases Epidemiological and Public Health Approaches, 94800 Villejuif, France</aff><aff id="Aff4"><label>4</label>Laboratory of Clinical Immunology, Department of Microbiology and Immunology, KU Leuven, Louvain, Belgium</aff><aff id="Aff5"><label>5</label>Transylvania University Brasov, Brasov, Romania</aff><aff id="Aff6"><label>6</label>Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent, Belgium</aff><aff id="Aff7"><label>7</label>Allergy-Centre-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany</aff><aff id="Aff8"><label>8</label>Global Allergy and Asthma European Network (GA²LEN), Berlin, Germany</aff><aff id="Aff9"><label>9</label>iQ4U Consultants Ltd, London, UK</aff><aff id="Aff10"><label>10</label>Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark</aff><aff id="Aff11"><label>11</label>Woolcock Institute of Medical Research, University of Sydney and Sydney Local Health District, Glebe, NSW Australia</aff><aff id="Aff12"><label>12</label>University Pneumology Unit-AOU Molinette, Hospital City of Health and Science of Torino, Turin, Italy</aff><aff id="Aff13"><label>13</label>Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France</aff><aff id="Aff14"><label>14</label>Department of Pediatrics, Medical School, Federal University of Minas Gerais, Belo Horizonte, Brazil</aff><aff id="Aff15"><label>15</label>Asthma and Allergy Clinic, Humanitas University, Rozzano, Milan, Italy</aff><aff id="Aff16"><label>16</label>Division of Allergy/Immunology, University of South Florida, Tampa, FL USA</aff><aff id="Aff17"><label>17</label>Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="Aff18"><label>18</label>ProAR – Nucleo de Excelencia em Asma, Federal University of Bahia, Salvador, Brazil</aff><aff id="Aff19"><label>19</label>GARD Executive Committee, Salvador, Bahia Brazil</aff><aff id="Aff20"><label>20</label>EFA European Federation of Allergy and Airways Diseases Patients’ Associations, Brussels, Belgium</aff><aff id="Aff21"><label>21</label>EPAR U707 INSERM, Paris, France</aff><aff id="Aff22"><label>22</label>EPAR UMR-S UPMC, Paris VI, Paris, France</aff><aff id="Aff23"><label>23</label>Laboratoire de Pharmacologie Respiratoire UPRES EA220, Hôpital Foch, Suresnes Université Versailles, Saint-Quentin, France</aff><aff id="Aff24"><label>24</label>Center for Research in Health Technologies and Information Systems - CINTESIS, Universidade do Porto, Porto, Portugal</aff><aff id="Aff25"><label>25</label>Allergy Unit, Instituto CUF Porto e Hospital CUF Porto, Porto, Portugal</aff><aff id="Aff26"><label>26</label>Health Information and Decision Sciences Department - CIDES, Faculdade de Medicina, Universidade do Porto, Rua Dr. Plácido da Costa, s/n, 4200-450 Porto, Portugal</aff><aff id="Aff27"><label>27</label>Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands</aff><aff id="Aff28"><label>28</label>Institute of Health Policy and Management IBMG, Erasmus University, Rotterdam, The Netherlands</aff><aff id="Aff29"><label>29</label>Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland</aff><aff id="Aff30"><label>30</label>Federico II University Hospital Naples (R&D and DISMET), Naples, Italy</aff><aff id="Aff31"><label>31</label>Allergology Department, Centre de l’Asthme et des Allergies, Hôpital d’Enfants Armand-Trousseau (APHP), Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Equipe EPAR, 75013 Paris, France</aff><aff id="Aff32"><label>32</label>Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany</aff><aff id="Aff33"><label>33</label>Institute for Clinical Epidemiology and Biometry, University of Wuerzburg, Würzburg, Germany</aff><aff id="Aff34"><label>34</label>Center for Rhinology and Allergology, Wiesbaden, Germany</aff><aff id="Aff35"><label>35</label>Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland</aff><aff id="Aff36"><label>36</label>Clínica de Alergia, Asma y Pediatría, Hospital Médica Sur, Mexico City, Mexico</aff><aff id="Aff37"><label>37</label>Allergy and Clinical Immunology Department, Hospital CUF-Descobertas, Lisbon, Portugal</aff><aff id="Aff38"><label>38</label>ENT Department, Hospital Clinic, Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, Universitat de Barcelona, Barcelona, Catalonia Spain</aff><aff id="Aff39"><label>39</label>MedScript Ltd, Dundalk, County Louth, Ireland</aff><aff id="Aff40"><label>40</label>Section of Otolaryngology-Head and Neck Surgery, The University of Chicago Medical Center and The Pritzker School of Medicine, The University of Chicago, Chicago, IL USA</aff><aff id="Aff41"><label>41</label>Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC Australia</aff><aff id="Aff42"><label>42</label>Department of Immunology, Monash University, Melbourne, VIC Australia</aff><aff id="Aff43"><label>43</label>Center for Pediatrics and Child Health, Institute of Human Development, Royal Manchester Children’s Hospital, University of Manchester, Manchester, UK</aff><aff id="Aff44"><label>44</label>Allergy Department, 2nd Pediatric Clinic, Athens General Children’s Hospital “P&A Kyriakou”, University of Athens, Athens, Greece</aff><aff id="Aff45"><label>45</label>Department of Pediatrics, Nippon Medical School, Tokyo, Japan</aff><aff id="Aff46"><label>46</label>Allergy Diagnostic and Clinical Research Unit, University of Cape Town Lung Institute, Cape Town, South Africa</aff><aff id="Aff47"><label>47</label>Woodbrook Medical Centre, Loughborough, UK</aff><aff id="Aff48"><label>48</label>Allergy and Respiratory Research Group, The University of Edinburgh, Edinburgh, UK</aff><aff id="Aff49"><label>49</label>Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland</aff><aff id="Aff50"><label>50</label>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada</aff><aff id="Aff51"><label>51</label>Allergy and Respiratory Research Group, Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, UK</aff><aff id="Aff52"><label>52</label>Department of Pediatrics and Child Health, Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, MB Canada</aff><aff id="Aff53"><label>53</label>Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy</aff><aff id="Aff54"><label>54</label>Centre of Pneumology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal</aff><aff id="Aff55"><label>55</label>Department of ENT, Medical University of Graz, Graz, Austria</aff><aff id="Aff56"><label>56</label>Clinic of Children’s Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania</aff><aff id="Aff57"><label>57</label>Public Health Institute, Vilnius University, Vilnius, Lithuania</aff><aff id="Aff58"><label>58</label>European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium</aff><aff id="Aff59"><label>59</label>Department of Lung Diseases and Clinical Allergology, University of Turku, Turku, Finland</aff><aff id="Aff60"><label>60</label>Allergy Clinic, Terveystalo, Turku, Finland</aff><aff id="Aff61"><label>61</label>Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy</aff><aff id="Aff62"><label>62</label>Sachs’ Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden</aff><aff id="Aff63"><label>63</label>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</aff><aff id="Aff64"><label>64</label>Queen’s University, Belfast, Northern Ireland, UK</aff><aff id="Aff65"><label>65</label>Department of Pulmonology, Celal Bayar University, Manisa, Turkey</aff><aff id="Aff66"><label>66</label>Department of Dermatology, Medical University of Graz, Graz, Austria</aff><aff id="Aff67"><label>67</label>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland</aff><aff id="Aff68"><label>68</label>Department of Allergy and Immunology, Hospital Quirón Bizkaia, Erandio, Spain</aff><aff id="Aff69"><label>69</label>Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain</aff><aff id="Aff70"><label>70</label>IMIM (Hospital del Mar Research Institute), Barcelona, Spain</aff><aff id="Aff71"><label>71</label>CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain</aff><aff id="Aff72"><label>72</label>Universitat Pompeu Fabra (UPF), Barcelona, Spain</aff><aff id="Aff73"><label>73</label>Kyomed, Montpellier, France</aff><aff id="Aff74"><label>74</label>Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</aff><aff id="Aff75"><label>75</label>Department of Pediatric Pulmonology and Allergy, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="Aff76"><label>76</label>David Hide Asthma and Allergy Research Centre, Isle of Wight, UK</aff><aff id="Aff77"><label>77</label>Regionie Puglia, Bari, Italy</aff><aff id="Aff78"><label>78</label>Faculdade de Medicina de Lisboa, Portuguese National Programme for Respiratory Diseases (PNDR), Lisbon, Portugal</aff><aff id="Aff79"><label>79</label>Geriatric Unit, Department of Internal Medicine (DIBIMIS), University of Palermo, Palermo, Italy</aff><aff id="Aff80"><label>80</label>Department of Medicine, University of Cape Town, Cape Town, South Africa</aff><aff id="Aff81"><label>81</label>Section of Respiratory Disease, Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy</aff><aff id="Aff82"><label>82</label>Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands</aff><aff id="Aff83"><label>83</label>Department of Respiratory Medicine, National Institute of Diseases of the Chest and Hospital, Dhaka, Bangladesh</aff><aff id="Aff84"><label>84</label>Centre for Individualized Medicine, Department of Pediatrics, Faculty of Medicine, Linköping University, 58185 Linköping, Sweden</aff><aff id="Aff85"><label>85</label>Department of Dermatology and Allergy, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany</aff><aff id="Aff86"><label>86</label>Department of Respiratory Medicine and Allergology, University Hospital, Lund, Sweden</aff><aff id="Aff87"><label>87</label>Department of Geriatrics, Montpellier University Hospital, Montpellier, France</aff><aff id="Aff88"><label>88</label>EA 2991, Euromov, University Montpellier, Montpellier, France</aff><aff id="Aff89"><label>89</label>Department of Pathophysiology and Transplantation, IRCCS Fondazione Ca’Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy</aff><aff id="Aff90"><label>90</label>Pediatric Department, University of Verona Hospital, Verona, Italy</aff><aff id="Aff91"><label>91</label>Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy</aff><aff id="Aff92"><label>92</label>Second University of Naples and Institute of Translational Medicine, Italian National Research Council, Naples, Italy</aff><aff id="Aff93"><label>93</label>La Rochelle, France</aff><aff id="Aff94"><label>94</label>Montreal, QC Canada</aff><aff id="Aff95"><label>95</label>Quebec Heart and Lung Institute, Laval University, Quebec City, QC Canada</aff><aff id="Aff96"><label>96</label>Health Economics and Health Technology Assessment, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK</aff><aff id="Aff97"><label>97</label>Institute of Lung Health, Respiratory Biomedical Unit, University Hospitals of Leicester NHS Trust, Leicestershire, UK</aff><aff id="Aff98"><label>98</label>Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK</aff><aff id="Aff99"><label>99</label>Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany</aff><aff id="Aff100"><label>100</label>University of Medicine and Pharmacy Victor Babes, Timisoara, Romania</aff><aff id="Aff101"><label>101</label>Royal Brompton Hospital NHS, Imperial College London, London, UK</aff><aff id="Aff102"><label>102</label>Centro Medico Docente La Trinidad, Caracas, Venezuela</aff><aff id="Aff103"><label>103</label>National Heart and Lung Institute, Imperial College London, London, UK</aff><aff id="Aff104"><label>104</label>Montpellier, Région Languedoc Roussillon France</aff><aff id="Aff105"><label>105</label>S. Allergologia, S. Medicina Interna, Hospital Vall d’Hebron, Barcelona, Spain</aff><aff id="Aff106"><label>106</label>CEDOC, Respiratory Research Group, Nova Medical School, Campo dos Martires da Patria, Lisbon, Portugal</aff><aff id="Aff107"><label>107</label>Serviço de Imunoalergologia, Centro Hospitalar de Lisboa Central, EPE, Lisbon, Portugal</aff><aff id="Aff108"><label>108</label>Regional Ministry of Health of Andalusia, Seville, Spain</aff><aff id="Aff109"><label>109</label>Department of Paediatrics, Oslo University Hospital, Oslo, Norway</aff><aff id="Aff110"><label>110</label>University of Oslo, Oslo, Norway</aff><aff id="Aff111"><label>111</label>Allergy and Asthma Associates of Southern California, Mission Viejo, CA USA</aff><aff id="Aff112"><label>112</label>Allergy and Immunology Laboratory, Metropolitan University, Simon Bolivar University, Barranquilla, Colombia</aff><aff id="Aff113"><label>113</label>SLaai, Sociedad Latinoamericana de Allergia, Asma e Immunologia, Cartagena, Colombia</aff><aff id="Aff114"><label>114</label>Gérontopôle de Toulouse, 31059 Toulouse, France</aff><aff id="Aff115"><label>115</label>Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete Greece</aff><aff id="Aff116"><label>116</label>School of Medicine, University CEU San Pablo, Madrid, Spain</aff><aff id="Aff117"><label>117</label>Chachava Clinic, David Tvildiani Medical University-AIETI Medical School, Grigol Robakidze University, Tbilisi, Georgia</aff><aff id="Aff118"><label>118</label>Pulmonolory Research Institute FMBA, Moscow, Russia</aff><aff id="Aff119"><label>119</label>GARD Executive Committee, Moscow, Russia</aff><aff id="Aff120"><label>120</label>Medicine Department, IRCCS-Azienda Ospedaliera Universitaria San Martino, Genoa, Italy</aff><aff id="Aff121"><label>121</label>ICVS/3B’s-PT Government Associate Laboratory, Life and Health Sciences, Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal</aff><aff id="Aff122"><label>122</label>Department of Medicine, Nova Southeastern University, Davie, FL USA</aff><aff id="Aff123"><label>123</label>EIP on AHA, European Innovation Partnership on Active and Healthy Ageing, Reference Site, Scottish Centre for Telehealth and Telecare, NHS 24, Glasgow, UK</aff><aff id="Aff124"><label>124</label>Department of Pediatric, Imperial College London, London, UK</aff><aff id="Aff125"><label>125</label>The Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</aff><aff id="Aff126"><label>126</label>Department of Dermatology and Allergy, Technische Universität München, Munich, Germany</aff><aff id="Aff127"><label>127</label>ZAUM-Center for Allergy and Environment, Helmholtz Center Munich, Munich, Germany</aff><aff id="Aff128"><label>128</label>AQuAS, Barcelona, Spain</aff><aff id="Aff129"><label>129</label>EUREGHA, European Regional and Local Health Association, Brussels, Belgium</aff><aff id="Aff130"><label>130</label>Allergology and Immunology Discipline, “Luliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania</aff><aff id="Aff131"><label>131</label>Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON Canada</aff><aff id="Aff132"><label>132</label>Peercode DV, Amsterdam, The Netherlands</aff><aff id="Aff133"><label>133</label>Respiratory Diseases Department, Rangueil-Larrey Hospital, Toulouse, France</aff><aff id="Aff134"><label>134</label>Service de Physiologie Respiratoire, Hôpital Cochin, Université Paris-Descartes, Assistance Publique-Hôpitaux de Paris, Paris, France</aff><aff id="Aff135"><label>135</label>University Clinic of Pulmology and Allergy, Medical Faculty, Ss Cyril and Methodius University, Skopje, Republic of Macedonia</aff><aff id="Aff136"><label>136</label>Service de Pneumo-Allergologie, Centre Hospitalo-Universitaire de Béni-Messous, Algers, Algeria</aff><aff id="Aff137"><label>137</label>Ecole des Mines, Alès, France</aff><aff id="Aff138"><label>138</label>Medical Faculty, Vilnius University, Vilnius, Lithuania</aff><aff id="Aff139"><label>139</label>Allergy and Clinical Immunology Section, National Heart and Lung Institute, Imperial College London, London, UK</aff><aff id="Aff140"><label>140</label>Guy’s and St Thomas’ NHS Trust, Kings College London, London, UK</aff><aff id="Aff141"><label>141</label>Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, MO USA</aff><aff id="Aff142"><label>142</label>Computing Science Department, Umeå University, Umeå, Sweden</aff><aff id="Aff143"><label>143</label>Four Computing Oy, Halikko, Finland</aff><aff id="Aff144"><label>144</label>Pediatric Allergy and Immunology Unit, Ain Shams University, Cairo, Egypt</aff><aff id="Aff145"><label>145</label>Department of Health, Social Services and Public Safety, Belfast, Northern Ireland, UK</aff><aff id="Aff146"><label>146</label>Global Allergy and Asthma Platform GAAPP, Altgasse 8-10, 1130 Vienna, Austria</aff><aff id="Aff147"><label>147</label>Division of Allergy, Department of Pediatric Medicine, The Bambino Gesù Children’s Research Hospital Holy See, Rome, Italy</aff><aff id="Aff148"><label>148</label>Education for Health, Warwick, UK</aff><aff id="Aff149"><label>149</label>Department of Epidemiology, Regional Health Service Lazio Region, Rome, Italy</aff><aff id="Aff150"><label>150</label>Athens Chest Hospital, Athens, Greece</aff><aff id="Aff151"><label>151</label>National Center for Disease Control and Public Health of Georgia, Tbilisi, Georgia</aff><aff id="Aff152"><label>152</label>Department of Pulmonary Diseases, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey</aff><aff id="Aff153"><label>153</label>Allergy and Immunology Division, Clinica Ricardo Palma, Lima, Peru</aff><aff id="Aff154"><label>154</label>Section of Allergology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</aff><aff id="Aff155"><label>155</label>Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Mexico</aff><aff id="Aff156"><label>156</label>Center of Tuberculosis and Lung Diseases, Latvian Association of Allergists, Riga, Latvia</aff><aff id="Aff157"><label>157</label>Faculty of the Department of Neurology, University of Washington School of Medicine, Seattle, WA USA</aff><aff id="Aff158"><label>158</label>National eHealth Centre, University Hospital Olomouc, Olomouc, Czech Republic</aff><aff id="Aff159"><label>159</label>Immunology and Allergy Division Clinical Hospital, University of Chile, Santiago, Chile</aff><aff id="Aff160"><label>160</label>Department of Respiratory Diseases, Odense University Hospital, Odense, Denmark</aff><aff id="Aff161"><label>161</label>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="Aff162"><label>162</label>Vienna Challenge Chamber, Vienna, Austria</aff><aff id="Aff163"><label>163</label>Department of Paediatrics and Child Health, University College Cork, Cork, Ireland</aff><aff id="Aff164"><label>164</label>Université Paris-Sud, Le Kremlin Bicêtre, France</aff><aff id="Aff165"><label>165</label>Service de Pneumologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France</aff><aff id="Aff166"><label>166</label>Inserm UMR_S999, Le Kremlin Bicêtre, France</aff><aff id="Aff167"><label>167</label>School of Psychology, Plymouth University, Plymouth, UK</aff><aff id="Aff168"><label>168</label>Department of Medicine and Surgery, University of Salerno, Baronissi, Italy</aff><aff id="Aff169"><label>169</label>Libra Foundation, Buenos Aires, Argentina</aff><aff id="Aff170"><label>170</label>Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, London, UK</aff><aff id="Aff171"><label>171</label>MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK</aff><aff id="Aff172"><label>172</label>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium</aff><aff id="Aff173"><label>173</label>Medical Commission, Montpellier University Hospital, Montpellier, France</aff><aff id="Aff174"><label>174</label>Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Gyeonggi-do South Korea</aff><aff id="Aff175"><label>175</label>Department of Clinical Immunology, Wrocław Medical University, Wrocław, Poland</aff><aff id="Aff176"><label>176</label>Ukrainian Medical Stomatological Academy, Poltava, Ukraine</aff><aff id="Aff177"><label>177</label>Laboratory of Molecular Immunology, National Research Center, Institute of Immunology, Federal Medicobiological Agency, Moscow, Russia</aff><aff id="Aff178"><label>178</label>Pediatric Allergy and Asthma Unit, School of Medicine, Hacettepe University, Ankara, Turkey</aff><aff id="Aff179"><label>179</label>Immunology and Allergy Division, Department of Chest Diseases, School of Medicine, Hacettepe University, Ankara, Turkey</aff><aff id="Aff180"><label>180</label>First Department of Family Medicine, Medical University of Lodz, Lodz, Poland</aff><aff id="Aff181"><label>181</label>Department of Medicine, McMaster University, Health Sciences Centre 3V47, 1280 Main Street West, Hamilton, ON Canada</aff><aff id="Aff182"><label>182</label>Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="Aff183"><label>183</label>GARD, Geneva, Switzerland</aff><aff id="Aff184"><label>184</label>Department of Respiratory Medicine, Faculty of Medicine and Dentistry, University Hospital Olomouc, Olomouc, Czech Republic</aff><aff id="Aff185"><label>185</label>Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children’s Hospital, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="Aff186"><label>186</label>Department of Immunology, Rheumatology and Allergy and HARC, Medical University of Lodz, Lodz, Poland</aff><aff id="Aff187"><label>187</label>Children’s Hospital, University of Helsinki, Helsinki, Finland</aff><aff id="Aff188"><label>188</label>Clinic of Infectious, Chest Diseases, Dermatology and Allergology, Vilnius University, Vilnius, Lithuania</aff><aff id="Aff189"><label>189</label>VIB Inflammation Research Center, Ghent University, Ghent, Belgium</aff><aff id="Aff190"><label>190</label>Department for Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany</aff><aff id="Aff191"><label>191</label>University of Medicine and Pharmacy, Hochiminh City, Vietnam</aff><aff id="Aff192"><label>192</label>Divisions of Allergy and Immunology, Department of Internal Medicine and Pediatrics, University of Tennessee College of Medicine, Germantown, TN USA</aff><aff id="Aff193"><label>193</label>Scottish Centre for Respiratory Research, Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, UK</aff><aff id="Aff194"><label>194</label>State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China</aff><aff id="Aff195"><label>195</label>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</aff><aff id="Aff196"><label>196</label>Department of Pulmonary Medicine, CHU Sart-Tilman, Liege, Belgium</aff><aff id="Aff197"><label>197</label>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</aff><aff id="Aff198"><label>198</label>The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK</aff><aff id="Aff199"><label>199</label>Service de Pneumo-allergologie, Hôpital Saint-Joseph, Paris, France</aff><aff id="Aff200"><label>200</label>Service de Pneumologie, UMR INSERM, UMR1087 and CNR 6291, l’institut du Thorax, University of Nantes, Nantes, France</aff><aff id="Aff201"><label>201</label>Department of Pulmonary Medicine, Rashid Hospital, Dubai, UAE</aff><aff id="Aff202"><label>202</label>Biomax Informatics AG, Munich, Germany</aff><aff id="Aff203"><label>203</label>Department of Respiratory Medicine, University of Bratislava, Bratislava, Slovakia</aff><aff id="Aff204"><label>204</label>Institute of Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal</aff><aff id="Aff205"><label>205</label>Ageing@Coimbra EIP-AHA Reference Site, Coimbra, Portugal</aff><aff id="Aff206"><label>206</label>Department of Medicine (RCSI), Bon Secours Hospital, Glasnevin, Dublin, Ireland</aff><aff id="Aff207"><label>207</label>Kronikgune, Basque Region, Spain</aff><aff id="Aff208"><label>208</label>Laboratory of Behavioral Immunology Research, Division of Clinical Immunology and Allergy, The University of Mississippi Medical Center, Jackson, MS USA</aff><aff id="Aff209"><label>209</label>Tobacco Control Research Centre, Iranian Anti Tobacco Association, Tehran, Iran</aff><aff id="Aff210"><label>210</label>Department of Paediatrics, Maputo Central Hospital, Maputo, Mozambique</aff><aff id="Aff211"><label>211</label>Allergy and Asthma Medical Group and Research Center, San Diego, CA USA</aff><aff id="Aff212"><label>212</label>Department of Physiology, CHRU, PhyMedExp, INSERM U1046, CNRS UMR 9214, University Montpellier, Montpellier, France</aff><aff id="Aff213"><label>213</label>Hautklinik - Klinik für Dermatologie & Allergologie, Universitätsklinikum der RWTH Aachen, Aachen, Germany</aff><aff id="Aff214"><label>214</label>Croatian Pulmonary Society, Zagreb, Croatia</aff><aff id="Aff215"><label>215</label>National Institute of Pneumology M. Nasta, Bucharest, Romania</aff><aff id="Aff216"><label>216</label>Faculty of Medicine, University of Belgrade, Belgrade, Serbia</aff><aff id="Aff217"><label>217</label>Serbian Association for Asthma and COPD, Belgrade, Serbia</aff><aff id="Aff218"><label>218</label>Caisse d’assurance retraite et de la santé au travail du Languedoc-Roussillon (CARSAT-LR), Montpellier, France</aff><aff id="Aff219"><label>219</label>National Center for Research in Chronic Respiratory Diseases, Tishreen University School of Medicine, Latakia, Syria</aff><aff id="Aff220"><label>220</label>Department of Public Health and Health Products, EA 4064, Paris Descartes University-Sorbonne Paris Cité, Paris, France</aff><aff id="Aff221"><label>221</label>Paris Municipal Department of Social Action, Childhood, and Health, Paris, France</aff><aff id="Aff222"><label>222</label>Institute of Medical Statistics, Informatics and Epidemiology, Medical Faculty, University of Cologne, Cologne, Germany</aff><aff id="Aff223"><label>223</label>Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy</aff><aff id="Aff224"><label>224</label>Scientific Centre of Children’s Health Under the Russian Academy of Medical Sciences, Moscow, Russia</aff><aff id="Aff225"><label>225</label>Hospital de Niños Orlando Alassia, Santa Fe, Argentina</aff><aff id="Aff226"><label>226</label>Hospital of the Hospitaller Brothers in Buda, Budapest, Hungary</aff><aff id="Aff227"><label>227</label>Neumología y Alergología Infantil, Hospital La Fe, Valencia, Spain</aff><aff id="Aff228"><label>228</label>Department of Internal Medicine, Centro Hospitalar Sao Joao, Porto, Portugal</aff><aff id="Aff229"><label>229</label>ENT Department, University Hospital of Kinshasa, Kinshasa, Congo</aff><aff id="Aff230"><label>230</label>National Hospital Organization, Tokyo National Hospital, Tokyo, Japan</aff><aff id="Aff231"><label>231</label>Department of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan</aff><aff id="Aff232"><label>232</label>Department of Otolaryngology, Nippon Medical School, Tokyo, Japan</aff><aff id="Aff233"><label>233</label>Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle, Ouagadougou, Burkina Faso</aff><aff id="Aff234"><label>234</label>Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Pisa, Italy</aff><aff id="Aff235"><label>235</label>Department of Comparative Medicine, Messerli Research Institute of the University of Veterinary Medicine, Medical University, Vienna, Austria</aff><aff id="Aff236"><label>236</label>Department of Immunology and Allergology, Faculty of Medicine and Faculty Hospital in Pilsen, Charles University in Prague, Pilsen, Czech Republic</aff><aff id="Aff237"><label>237</label>Respiratory Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy</aff><aff id="Aff238"><label>238</label>Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea</aff><aff id="Aff239"><label>239</label>University of Southern Denmark, Kolding, Denmark</aff><aff id="Aff240"><label>240</label>Allergy Unit, CUF-Porto Hospital and Institute, Porto, Portugal</aff><aff id="Aff241"><label>241</label>Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany</aff><aff id="Aff242"><label>242</label>Conseil Général de l’Economie, Ministère de l’Economie, de l’Industrie et du Numérique, Paris, France</aff><aff id="Aff243"><label>243</label>Société de Pneumologie de Langue Française, Espace francophone de Pneumologie, Paris, France</aff><aff id="Aff244"><label>244</label>Département de pédiatrie, CHU de Grenoble, Grenoble, France</aff><aff id="Aff245"><label>245</label>Children’s Hospital Srebrnjak, Zagreb, Croatia</aff><aff id="Aff246"><label>246</label>School of Medicine, University J.J. Strossmayer, Osijek, Croatia</aff><aff id="Aff247"><label>247</label>Karl Landsteiner Institute for Clinical and Experimental Pneumology, Hietzing Hospital, Vienna, Austria</aff><aff id="Aff248"><label>248</label>Clinic of Allergy and Asthma, Medical University Sofia, Sofia, Bulgaria</aff><aff id="Aff249"><label>249</label>University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="Aff250"><label>250</label>Laboratory of Medical Allergology, Allergy Clinic, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark</aff><aff id="Aff251"><label>251</label>Academic Centre of Primary Care, University of Aberdeen, Aberdeen, Scotland, UK</aff><aff id="Aff252"><label>252</label>Research in Real-Life, Cambridge, UK</aff><aff id="Aff253"><label>253</label>LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research (DZL), Grosshansdorf, Germany</aff><aff id="Aff254"><label>254</label>Department of Medicine, Christian Albrechts University, Airway Research Center North, German Center for Lung Research (DZL), Kiel, Germany</aff><aff id="Aff255"><label>255</label>NHS Foundation Trust, University Hospitals of Southampton, Southampton, UK</aff><aff id="Aff256"><label>256</label>Centre of Pneumology, Coimbra University Hospital, Coimbra, Portugal</aff><aff id="Aff257"><label>257</label>Polibienestar Research Institute, University of Valencia, Valencia, Spain</aff><aff id="Aff258"><label>258</label>Department of Geriatrics, Getafe University Hospital, Madrid, Spain</aff><aff id="Aff259"><label>259</label>Association Asthme et Allergie, Paris, France</aff><aff id="Aff260"><label>260</label>Primary Care Respiratory Research Unit, Institutode Investigación Sanitaria de Palma IdisPa, Palma de Mallorca, Spain</aff><aff id="Aff261"><label>261</label>Allergy Unit, Complesso Integrato Columbus, Rome, Italy</aff><aff id="Aff262"><label>262</label>Serviço de Imunoalergologia, Hospital da Luz, Lisbon, Portugal</aff><aff id="Aff263"><label>263</label>Hospital de Clinicas, University of Parana, Curitiba, Brazil</aff><aff id="Aff264"><label>264</label>Division of Allergy Asthma and Clinical Immunology, Emek Medical Center, Afula, Israel</aff><aff id="Aff265"><label>265</label>Allergy and Clinical Immunology Department, Centro Médico-Docente La Trinidad and Clínica El Avila, Caracas, Venezuela</aff><aff id="Aff266"><label>266</label>Faculty of Medicine, Autononous University of Madrid, Madrid, Spain</aff><aff id="Aff267"><label>267</label>The Royal National TNE Hospital, University College London, London, UK</aff><aff id="Aff268"><label>268</label>DIBIMIS, University of Palermo, Palermo, Italy</aff><aff id="Aff269"><label>269</label>Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland</aff><aff id="Aff270"><label>270</label>Otolaryngology and Head and Neck Surgery, CHU Rangueil-Larrey, Toulouse, France</aff><aff id="Aff271"><label>271</label>Child Health, Queen’s University, Belfast, Northern Ireland, UK</aff><aff id="Aff272"><label>272</label>Royal Belfast Hospital for Sick Children, Belfast, Northern Ireland, UK</aff><aff id="Aff273"><label>273</label>INSERM, Université Grenoble Alpes, IAB, U 1209, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Université Joseph Fourier, Grenoble, France</aff><aff id="Aff274"><label>274</label>Sociedad Paraguaya de Alergia Asma e Inmunologıa, Asunción, Paraguay</aff><aff id="Aff275"><label>275</label>Julius Center of Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands</aff><aff id="Aff276"><label>276</label>Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil</aff><aff id="Aff277"><label>277</label>Kyrgyzstan National Centre of Cardiology and Internal Medicine, Euro-Asian Respiratory Society, Bishkek, Kyrgyzstan</aff><aff id="Aff278"><label>278</label>Pulmonary Division, Heart Institute (InCor), Hospital da Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Brazil</aff><aff id="Aff279"><label>279</label>Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands</aff><aff id="Aff280"><label>280</label>European Union Geriatric Medicine Society (EUGMS), Helsinki, Finland</aff><aff id="Aff281"><label>281</label>Department of Epidemiology, CAPHRI School of Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands</aff><aff id="Aff282"><label>282</label>Pneumology and Allergy Department, Hospital Clínic, Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, Barcelona, Spain</aff><aff id="Aff283"><label>283</label>PELyon, Lyon, France</aff><aff id="Aff284"><label>284</label>HESPER 7425, Health Services and Performance Resarch, Université Claude Bernard Lyon, Villeurbanne, France</aff><aff id="Aff285"><label>285</label>University Hospital, Stockholm, Sweden</aff><aff id="Aff286"><label>286</label>Department of Chest Medicine, Centre Hospitalier Universitaire UCL Namur, Université Catholique de Louvain, Yvoir, Belgium</aff><aff id="Aff287"><label>287</label>Philippines Society of Allergy, Asthma and Immunology, Manila, Philippines</aff><aff id="Aff288"><label>288</label>Pulmonary Unit, Department of Cardiology, Thoracic and Vascular Medicine, Arcispedale S. Maria Nuova/IRCCS, Research Hospital, Reggio Emilia, Italy</aff><aff id="Aff289"><label>289</label>Regional Agency for Health and Social Care, Reggio Emilia, Italy</aff><aff id="Aff290"><label>290</label>Finnish Lung Association (FILHA), Helsinki, Finland</aff><aff id="Aff291"><label>291</label>Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Pisa, Italy</aff><aff id="Aff292"><label>292</label>CNR Institute of Biomedicine and Molecular Immunology “A. Monroy”, Palermo, Italy</aff><aff id="Aff293"><label>293</label>Sotiria Hospital, Athens, Greece</aff><aff id="Aff294"><label>294</label>Department of Otorhinolaryngology, HNO-Klinik, Universitätsklinikum Düsseldorf, Düsseldorf, Germany</aff><aff id="Aff295"><label>295</label>Asthma UK, Mansell Street, London, UK</aff><aff id="Aff296"><label>296</label>Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore</aff><aff id="Aff297"><label>297</label>Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany</aff><aff id="Aff298"><label>298</label>Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC USA</aff><aff id="Aff299"><label>299</label>IPCRG, Aberdeen, Scotland, UK</aff><aff id="Aff300"><label>300</label>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK</aff><aff id="Aff301"><label>301</label>Department of Research, Olmsted Medical Center, Rochester, MN USA</aff><aff id="Aff302"><label>302</label>Medical School, University of Cyprus, Nicosia, Cyprus</aff><aff id="Aff303"><label>303</label>The Allergy and Asthma Institute, Lahore, Pakistan</aff><aff id="Aff304"><label>304</label>Social Sciences, University of Southampton, Southampton, UK</aff><aff id="Aff305"><label>305</label>Department of Paediatrics and Child Health, Red Cross Children’s Hospital, University of Cape Town, Cape Town, South Africa</aff><aff id="Aff306"><label>306</label>MRC Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa</aff><aff id="Aff307"><label>307</label>Universidad Católica de Córdoba, Córdoba, Argentina</aff><aff id="Aff308"><label>308</label>Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Beijing, China</aff><aff id="Aff309"><label>309</label>Beijing Institute of Otolaryngology, Beijing, China</aff><aff id="Aff310"><label>310</label>University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia</aff><aff id="Aff311"><label>311</label>Northern Health Alliance, Newcastle, UK</aff><aff id="Aff312"><label>312</label>CHRU Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France</aff></contrib-group><pub-date pub-type="epub"><day>30</day><month>12</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>30</day><month>12</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>6</volume><elocation-id>47</elocation-id><history><date date-type="received"><day>10</day><month>11</month><year>2016</year></date><date date-type="accepted"><day>5</day><month>12</month><year>2016</year></date></history><permissions><copyright-statement>© The Author(s) 2016</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><p>The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA—disseminated and implemented in over 70 countries globally—is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (<italic>Contre les Maladies Chroniques pour un Vieillissement Actif</italic>)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>ARIA</kwd><kwd>Rhinitis</kwd><kwd>ICT</kwd><kwd>EIP on AHA</kwd><kwd>Mobile technology</kwd><kwd>AIRWAYS ICPs</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2016</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec id="Sec1"><title>Background</title><p>The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization (WHO) workshop in 1999 (published in 2001) [<xref ref-type="bibr" rid="CR1">1</xref>]. The goals were (1) to propose a new allergic rhinitis (AR) classification using persistence and severity of symptoms in order to more closely reflect patients’ needs, (2) to promote the concept of multi-morbidity in asthma and rhinitis as a key factor for patient management, (3) to develop guidelines with all stakeholders, (4) to include experts from developed and developing countries and (5) to initiate global implementation among health care professionals (HCPs) and patients.</p><p>Patients, clinicians and other HCPs are confronted with various treatment choices for the management of AR. This contributes to considerable variation in clinical practice. Worldwide, patients, clinicians and other HCPs are faced with uncertainty about the relative merits and downsides of the many AR treatment options available. The first ARIA workshop report used the Shekelle evidence-based methodology [<xref ref-type="bibr" rid="CR1">1</xref>, <xref ref-type="bibr" rid="CR2">2</xref>]. It was the first guideline in chronic disease to assess multi-morbid conditions (i.e. asthma and rhinitis in the same patient). In 2008, ARIA was updated using the same evidence-based system [<xref ref-type="bibr" rid="CR3">3</xref>]. More transparent reporting of guidelines to facilitate understanding and acceptance was needed. In its 2010 Revision, ARIA was the first chronic respiratory disease guideline to adopt the GRADE (Grading of Recommendation, Assessment, Development and Evaluation) approach, an advanced evidence evaluation methodology [<xref ref-type="bibr" rid="CR4">4</xref>–<xref ref-type="bibr" rid="CR7">7</xref>]. A new revision is pending.</p><p>ARIA has been disseminated and is implemented in over 70 countries around the world [<xref ref-type="bibr" rid="CR8">8</xref>]. It is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (<italic>Contre les Maladies Chroniques pour un Vieillissement Actif</italic>)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves [<xref ref-type="bibr" rid="CR9">9</xref>].</p><p>The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status in order to reduce health and social inequalities incurred by the disease.</p></sec><sec id="Sec2"><title>AIRWAYS ICPs: the ARIA 2016 political agenda</title><p>In 2012, the European Commission launched the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA; DG Santé and DG CONNECT) to enhance EU competitiveness and tackle societal challenges through research and innovation [<xref ref-type="bibr" rid="CR10">10</xref>]. The B3 Action Plan is devoted to the scaling up and replication of successful innovative integrated care models for chronic diseases amongst older patients.</p><p>Chronic respiratory diseases were selected to be the pilot for chronic diseases of the EIP on AHA Action Plan B3 (Integrated care pathways for airway diseases, AIRWAYS ICPs) [<xref ref-type="bibr" rid="CR11">11</xref>, <xref ref-type="bibr" rid="CR12">12</xref>] with a life cycle approach [<xref ref-type="bibr" rid="CR13">13</xref>]. Several effective plans exist in Europe for chronic respiratory diseases, but they are rarely deployed to other regions or countries.</p><p>AIRWAYS ICPs aims to launch a collaboration to develop practical multi-sectoral care pathways (i.e. ICPs) in European countries and regions to reduce chronic respiratory disease burden, mortality and multi-morbidity, while maintaining patients’ quality-of-life (QOL) [<xref ref-type="bibr" rid="CR11">11</xref>, <xref ref-type="bibr" rid="CR14">14</xref>]. AIRWAYS-ICPs proposes a feasible, achievable and manageable project (from science to guidelines and policies) using existing networks. It brings together key stakeholders including end users, public authorities, industry partners, involved in the innovation cycle, from research to adoption, as well as those engaged in standardisation and regulation. The Action Plan of AIRWAYS ICPs has been devised [<xref ref-type="bibr" rid="CR11">11</xref>], implemented [<xref ref-type="bibr" rid="CR14">14</xref>] and scaled up [<xref ref-type="bibr" rid="CR15">15</xref>].</p><p>AIRWAYS ICPs is a GARD (WHO Global Alliance against Chronic Respiratory Diseases) [<xref ref-type="bibr" rid="CR16">16</xref>] research demonstration project. Its deployment beyond Europe is carried out via GARD.</p><p>One AIRWAYS-ICPs activity is the development of multi-sectoral care pathways for rhinitis and asthma and their multi-morbidities, implementing emerging technologies for predictive medicine across the patient life cycle [<xref ref-type="bibr" rid="CR13">13</xref>].</p></sec><sec id="Sec3"><title>From guidelines to integrated care pathways: MACVIA-ARIA Sentinel NetworK (MASK)</title><sec id="Sec4"><title>Best practice, guideline and care pathways</title><p>A <italic>good</italic> or <italic>best practice</italic> is a technique, method, process, activity, incentive, or reward believed to be more effective than any other technique, method, process, etc. when applied to a particular condition or circumstance. A best practice can be adopted as a standard process or be used as a guideline (U.S. Dept. of Veterans Affairs [<xref ref-type="bibr" rid="CR17">17</xref>]).</p><p>A <italic>guideline</italic> is a statement to determine a course of action. It aims to streamline particular processes according to a set routine or sound practice. By definition, following a guideline is never mandatory. Guidelines are not binding and are not enforced (U.S. Dept. of Veterans Affairs [<xref ref-type="bibr" rid="CR17">17</xref>]).</p><p>“<italic>Clinical practice guidelines</italic> are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances” (Institute of Medicine, 1990). These clinical practice guidelines define the role of specific diagnostic and treatment modalities. The statements include recommendations based on evidence intended to help HCPs and providers in their practice [<xref ref-type="bibr" rid="CR18">18</xref>].</p><p><italic>The Integrated Care Pathway</italic> (ICP) concept was initiated in 1985 by Zander and Bower [<xref ref-type="bibr" rid="CR19">19</xref>]. ICPs are structured multi-disciplinary care plans detailing key steps of patient care for a given clinical problem [<xref ref-type="bibr" rid="CR20">20</xref>]. They promote the translation of guidelines into local protocols and their subsequent application to clinical practice. An ICP forms all or part of the clinical record, documents the care given, and facilitates the evaluation of outcomes for continuous quality improvement [<xref ref-type="bibr" rid="CR21">21</xref>]. They can help empower patients and their carers (health and social). ICPs differ from clinical practice guidelines as they are utilized by a multi-disciplinary team, and focus on the quality and co-ordination of care. ICPs need to have a mechanism for recording variations/deviations from planned care. Like guidelines, an ICP is a guide to treatment, and clinicians are free to exercise their own professional judgment as appropriate. However, any alteration to the practice identified within this ICP must be noted as a variance [<xref ref-type="bibr" rid="CR22">22</xref>]. Variance analysis is a critical part of developing and using ICPs [<xref ref-type="bibr" rid="CR23">23</xref>]. The resulting analysis can be used to amend the ICP itself if, for the majority of patients, the practice is different to the pathway (Table <xref rid="Tab1" ref-type="table">1</xref>).<table-wrap id="Tab1"><label>Table 1</label><caption><p>Definition of guidelines, practice protocols and ICPs. </p><p>Adapted from <ext-link ext-link-type="uri" xlink:href="http://www.implementationcentral.com/guidelines_8.html">http://www.implementationcentral.com/guidelines_8.html</ext-link></p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left"></th><th align="left">Guideline</th><th align="left">Clinical practice guidelines</th><th align="left">Care pathway</th></tr></thead><tbody><tr><td align="left">Focus</td><td align="left">Specific clinical circumstances</td><td align="left">Treatment and/or prevention</td><td align="left">The quality and co-ordination of care</td></tr><tr><td align="left">Definition</td><td align="left">Systematically developed statements to help practitioners and patients make decisions about appropriate health care</td><td align="left">A suggested course of treatment and/or treatment service for a specific diagnosis, functional deficit or problem area</td><td align="left">Structured, multi-disciplinary plans of care</td></tr><tr><td align="left">Goals</td><td align="left">Makes specific recommendations on health care and links these to research evidence</td><td align="left">Highlights major therapeutic or preventive interventions<break></break>Identifies choices of different courses or paths of treatment</td><td align="left">Supports the implementation of clinical guidelines and protocols</td></tr><tr><td align="left">Outputs</td><td align="left">Provides a summary and appraisal of the best available research evidence or expert consensus<break></break>Highlights the strength of the evidence underlying each recommendation<break></break>Describes barriers and facilitators for each recommendation</td><td align="left">Provides a logical flow of interventions. Provides detailed recommendations that build on those made in SPCs guidelines</td><td align="left">Provides detailed guidance for each stage in the management of a patient and key performance indicators</td></tr><tr><td align="left">Users</td><td align="left">Clinicians, patients and third parties (all stakeholders involved)</td><td align="left">Specific to clinicians</td><td align="left">A multidisciplinary clinical team</td></tr><tr><td align="left">Components</td><td align="left">(1) Appraisal of literature (research evidence or expert consensus)<break></break>(2) Summary of recommendations<break></break>(3) An outline of how guidelines should be implemented and how adherence monitored</td><td align="left">List of major therapeutic or preventive interventions<break></break>Goals: When interventions should be achieved<break></break>Options for different choices of treatment and/or prevention</td><td align="left">(1) Timeline<break></break>(2) Categories of care/intervention<break></break>(3) Intermediate and long term outcome criteria<break></break>(4) A variance record</td></tr></tbody></table></table-wrap></p></sec><sec id="Sec5"><title>Multisectoral care pathways for rhinitis and asthma using ICT</title><p>A large number of AR patients do not consult physicians because they think their AR symptoms are ‘normal’ and/or trivial. However, AR negatively impacts social life, school and work productivity [<xref ref-type="bibr" rid="CR3">3</xref>]. Many AR patients use over the counter (OTC) drugs [<xref ref-type="bibr" rid="CR24">24</xref>] and only a fraction have had a medical consultation. The vast majority of patients who visit GPs or specialists have moderate/severe rhinitis [<xref ref-type="bibr" rid="CR25">25</xref>–<xref ref-type="bibr" rid="CR29">29</xref>]. Thus, ICPs should consider a multi-disciplinary approach as proposed by AIRWAYS ICPs (Fig. <xref rid="Fig1" ref-type="fig">1</xref>).<fig id="Fig1"><label>Fig. 1</label><caption><p>Multi-sectoral care pathway for allergic rhinitis (from Bousquet et al. [<xref ref-type="bibr" rid="CR9">9</xref>])</p></caption><graphic xlink:href="13601_2016_137_Fig1_HTML" id="MO1"></graphic></fig></p><p>The variations/deviations of the ARIA recommendations from planned care have been assessed and several unmet needs identified. Disease severity is associated with several health outcomes, including quality of life [<xref ref-type="bibr" rid="CR25">25</xref>–<xref ref-type="bibr" rid="CR29">29</xref>], and should be considered in ICPs. The duration of rhinitis (intermittent/severe-persistent) is an important indicator of asthma multi-morbidity (in some but not all studies) [<xref ref-type="bibr" rid="CR30">30</xref>], duration of AR treatment and efficacy of treatment in AR [<xref ref-type="bibr" rid="CR27">27</xref>]. Most patients receive combinations of oral antihistamines and intra-nasal corticosteroids (INS) [<xref ref-type="bibr" rid="CR31">31</xref>–<xref ref-type="bibr" rid="CR33">33</xref>] which are not evaluated in guidelines using an appropriate methodology.</p></sec><sec id="Sec6"><title>Simple approach to assess control in allergic rhinitis</title><p>In asthma, the management strategy is based on disease control, current treatment and future risk (exacerbations, lung function decline) [<xref ref-type="bibr" rid="CR34">34</xref>–<xref ref-type="bibr" rid="CR36">36</xref>]. In AR, the switch from symptom severity to disease control to guide treatment decisions has been led by ARIA and is now expanding to include MACVIA (a reference site of the EIP on AHA, EU [<xref ref-type="bibr" rid="CR37">37</xref>]) to form an Action Plan (MACVIA-ARIA). New developments which have facilitated this process include (1) the introduction of the visual analogue scale (VAS) as the common validated language of AR control, (2) categorization of AR control using VAS score cut-offs, (3) incorporation of this VAS into simple interactive apps for both patients (<italic>ARIA Allergy Diary</italic>) and HCPs (<italic>ARIA Allergy Diary Companion</italic>) [<xref ref-type="bibr" rid="CR9">9</xref>, <xref ref-type="bibr" rid="CR38">38</xref>] and (4) the integration of all this knowledge into ICPs deployed by the EIP on AHA [<xref ref-type="bibr" rid="CR9">9</xref>].</p><p>The VAS represents a simple way of measuring control. It has been used in many diseases, including AR. VAS scores appear to be similar in different countries, for patients with moderate–severe intermittent or persistent rhinitis [<xref ref-type="bibr" rid="CR39">39</xref>, <xref ref-type="bibr" rid="CR40">40</xref>]. An advantage of the VAS is that it can be used in all age groups, including preschool children (guardian evaluation) [<xref ref-type="bibr" rid="CR41">41</xref>] and the elderly [<xref ref-type="bibr" rid="CR42">42</xref>, <xref ref-type="bibr" rid="CR43">43</xref>]. Furthermore, it can be used in a wide variety of languages [<xref ref-type="bibr" rid="CR39">39</xref>, <xref ref-type="bibr" rid="CR40">40</xref>, <xref ref-type="bibr" rid="CR42">42</xref>, <xref ref-type="bibr" rid="CR44">44</xref>–<xref ref-type="bibr" rid="CR48">48</xref>]. VAS scores vary with ARIA AR classification in many languages [<xref ref-type="bibr" rid="CR28">28</xref>, <xref ref-type="bibr" rid="CR44">44</xref>, <xref ref-type="bibr" rid="CR49">49</xref>, <xref ref-type="bibr" rid="CR50">50</xref>]. A VAS score of 50/100 mm suggests moderate–severe AR [<xref ref-type="bibr" rid="CR32">32</xref>, <xref ref-type="bibr" rid="CR51">51</xref>, <xref ref-type="bibr" rid="CR52">52</xref>], although in some studies this cut-off was >60 mm [<xref ref-type="bibr" rid="CR45">45</xref>]. The VAS has been used to define severe chronic upper airway disease (SCUAD [<xref ref-type="bibr" rid="CR53">53</xref>]). The minimal clinically important difference (MCID) during treatment was found to be 2.3/10 cm in the French population [<xref ref-type="bibr" rid="CR54">54</xref>] and may be generalized to other countries, but future studies may refine this cut-off score. VAS score changes appear to encompass both symptoms and disease-specific QOL [<xref ref-type="bibr" rid="CR54">54</xref>, <xref ref-type="bibr" rid="CR55">55</xref>].</p><p>As is the case for asthma, the best control of AR should be achieved as early as possible in order to (1) improve patient satisfaction and concordance with treatment and (2) reduce the AR burden including symptoms, reduced QoL, and school and work presenteeism/absenteeism. Untreated AR can impair driving ability and put patients at risk [<xref ref-type="bibr" rid="CR56">56</xref>]. The ultimate goal of AR control is to reduce the direct and indirect costs incurred by AR [<xref ref-type="bibr" rid="CR57">57</xref>–<xref ref-type="bibr" rid="CR60">60</xref>].</p><p>The variability in approaches to achieve disease control is challenging, and necessitates careful monitoring as well as the step up/step down of individualized therapeutic regimens over time. However, the challenges of managing AR are increased by the fact that patients do not often recognise their AR symptoms or confuse them with those of asthma or other multimorbidities such as rhinosinusitis [<xref ref-type="bibr" rid="CR61">61</xref>]. Therefore, it is important for patients, caregivers or HCPs to be able to use an AR symptom scoring system that is simple to use and rapidly responsive to change.</p><p>The aim is to encourage effective cross communication and achieve rapid and sustained disease control. MACVIA-ARIA has produced a simple VAS-based algorithm called the <italic>ARIA Clinical Decision Support System</italic> (CDSS) using a VAS score to guide treatment decisions in a step-up/step-down approach. This CDSS provides an individualized approach to AR pharmacotherapy (depending on medication availability and resources) [<xref ref-type="bibr" rid="CR62">62</xref>]. This approach holds the potential for optimal AR control while minimizing side effects and costs.</p></sec><sec id="Sec7"><title>MASK (MACVIA-ARIA Sentinel NetworK): rhinitis and asthma</title><p>MASK-rhinitis and asthma is a simple ICT tool used to implement ICPs for AR and asthma by means of a common language (for patients and HCPs) and a CDSS. Disease control is assessed by VAS, incorporated into apps for patients (<italic>ARIA Allergy Diary</italic>) and HCPs (<italic>ARIA Allergy Diary Companion</italic>), with the utility to assess patient QoL (weekly EQ-5D) [<xref ref-type="bibr" rid="CR63">63</xref>, <xref ref-type="bibr" rid="CR64">64</xref>] and school/work productivity (weekly WPAI-AS and daily VAS) [<xref ref-type="bibr" rid="CR25">25</xref>, <xref ref-type="bibr" rid="CR65">65</xref>, <xref ref-type="bibr" rid="CR66">66</xref>].</p><p>MASK-rhinitis and asthma will (1) allow patients and caregivers to screen for AR and asthma, and track their AR control (2) guide pharmacists in the prescription of OTC medications and referral of patients to physicians when appropriate, (3) allow primary care physicians to prescribe appropriate AR treatment, assess patients’ AR control and direct follow-ups in accordance with the CDSS and (4) encourage referral to specialists and outpatient clinics, if there is failure to gain AR control at the primary care level.</p><p>MASK-rhinitis and asthma will be important for establishing care pathways across the life cycle. It will stratify patients with severe uncontrolled disease and achieve better results in prevention and intervention trials guided by the use of an individualised and predictive medicine approach.</p></sec><sec id="Sec8"><title>The MASK tools: the <italic>ARIA Allergy Diary</italic> and <italic>ARIA Allergy Diary Companion</italic> apps</title><p><italic>The ARIA Allergy Diary</italic> is freely available in 15 EU countries, Australia, Mexico and Switzerland and in 15 languages (translated and back-translated, culturally adapted and legally compliant). It will also be deployed in Brazil, Canada and the USA. The companion app will be available in Autumn 2016.</p><p>A pilot study was completed in AR during the pollen season to assess the relevance of the <italic>ARIA Allergy Diary</italic> app. It showed the importance of the tool to stratify patients, assess their work productivity and improve quality of life (EQ-5D) (Bousquet et al., submitted). Studies in asthma are planned for the autumn and winter.</p><sec id="Sec9"><title>Questionnaires</title><p><italic>ARIA Allergy Diary</italic> users fill in simple questionnaires on asthma, rhinitis and the impact of the disease (globally, on work and school, on daily activities and on sleep) upon registration (Table <xref rid="Tab2" ref-type="table">2</xref>). The pilot study in around 5000 users (9% over 60 years of age) indicates that these questions are easily answered and can help to stratify patients with rhinitis.<table-wrap id="Tab2"><label>Table 2</label><caption><p>Baseline questionnaire</p></caption><table frame="hsides" rules="groups"><tbody><tr><td align="left">Q1: I have rhinitis: yes/no</td></tr><tr><td align="left">Q2: I have asthma: yes/no</td></tr><tr><td align="left">Q3: My symptoms (tick)</td></tr><tr><td align="left"> Runny nose</td></tr><tr><td align="left"> Itchy nose</td></tr><tr><td align="left"> Sneezing</td></tr><tr><td align="left"> Congestion (blocked nose)</td></tr><tr><td align="left"> Red eyes</td></tr><tr><td align="left"> Itchy eyes</td></tr><tr><td align="left"> Watery eyes</td></tr><tr><td align="left">Q4: How they affect me: my symptoms (tick)</td></tr><tr><td align="left"> Affect my sleep</td></tr><tr><td align="left"> Restrict my daily activities</td></tr><tr><td align="left"> Restrict my participation in school or work</td></tr><tr><td align="left"> Are troublesome</td></tr><tr><td align="left">Q5: Medications</td></tr><tr><td align="left">Q6: Are you currently receiving immunotherapy (a small dose of the thing you are allergic to, usually taken as an injection or placed under your tongue)? yes/no</td></tr><tr><td align="left"> If YES to Q6 (Q7 and Q8)</td></tr><tr><td align="left">Q7: What allergy is this?</td></tr><tr><td align="left"> Grass pollen</td></tr><tr><td align="left"> Parietaria pollen</td></tr><tr><td align="left"> Birch pollen</td></tr><tr><td align="left"> Other pollen</td></tr><tr><td align="left"> Dust mite</td></tr><tr><td align="left"> Animal</td></tr><tr><td align="left"> Cypress tree pollen</td></tr><tr><td align="left"> Don’t know</td></tr><tr><td align="left"> Add allergy</td></tr><tr><td align="left">Q8: How do you receive your treatment?</td></tr><tr><td align="left"> Injection</td></tr><tr><td align="left"> Tablet under the tongue</td></tr><tr><td align="left"> Drops under the tongue</td></tr><tr><td align="left"> Spray under the tongue</td></tr><tr><td align="left"> Other</td></tr></tbody></table></table-wrap></p><p>Moreover, two specific questionnaires are applied every week to assess disease impact on patients’ QoL (EQ-5D) [<xref ref-type="bibr" rid="CR63">63</xref>, <xref ref-type="bibr" rid="CR64">64</xref>] and productivity at work (WPAI-AS) [<xref ref-type="bibr" rid="CR25">25</xref>, <xref ref-type="bibr" rid="CR65">65</xref>, <xref ref-type="bibr" rid="CR66">66</xref>].</p></sec><sec id="Sec10"><title>Treatments received</title><p>A list of all treatments available for asthma, conjunctivitis and rhinitis is included in the <italic>ARIA Allergy Diary</italic>, and users select the treatment(s) they are taking. Multiple treatments may be selected, and users can update the information when (or if) their treatment changes (Fig. <xref rid="Fig2" ref-type="fig">2</xref>). The list has been customized for all 20 countries in which the <italic>ARIA Allergy Diary</italic> is available, using data from IMS Health. Information on allergen specific immunotherapy is also requested on the day of first use. A questionnaire on biologics for asthma is under development.<fig id="Fig2"><label>Fig. 2</label><caption><p>Screens on medications</p></caption><graphic xlink:href="13601_2016_137_Fig2_HTML" id="MO2"></graphic></fig></p></sec><sec id="Sec11"><title>Daily visual analogue scales</title><p>Geolocalized users assess their daily symptom control using the touchscreen functionality on their smart phone to click on 5 consecutive VASs (global symptoms due to allergic diseases, rhinitis, conjunctivitis, asthma and work productivity) (Fig. <xref rid="Fig3" ref-type="fig">3</xref>). These scales have been validated for AR and asthma criteria [<xref ref-type="bibr" rid="CR67">67</xref>–<xref ref-type="bibr" rid="CR71">71</xref>] and for work productivity (Bousquet et al., in preparation).<fig id="Fig3"><label>Fig. 3</label><caption><p>Screens on daily visual analogue scales</p></caption><graphic xlink:href="13601_2016_137_Fig3_HTML" id="MO3"></graphic></fig></p></sec><sec id="Sec12"><title>MASK-asthma</title><p>Besides the asthma VAS, a test to measure pulmonary function is being developed. It is expected to be added to the <italic>ARIA Allergy Diary</italic> by the end of 2016.</p></sec><sec id="Sec13"><title>Clinical decision support system</title><p>The MASK CDSS is incorporated into an app for HCPs (i.e. <italic>ARIA Allergy Diary Companion</italic>). This is essentially an algorithm to aid clinicians to select pharmacotherapy for patients with AR and to stratify their disease severity [<xref ref-type="bibr" rid="CR62">62</xref>]. It uses a simple step-up/step-down individualized approach to AR pharmacotherapy and may hold the potential for optimal control of symptoms, while minimizing side effects and costs. However, its use varies depending on the availability of medications in the different countries and on resources. A CDSS for asthma is also being developed.</p></sec><sec id="Sec14"><title>Ethics</title><p>The terms of use have been translated into all languages and customized according to the country’s legislation. They allow the use of anonymous data for research and commercial purposes. The app has a CE registration as a medical device class 1.</p></sec><sec id="Sec15"><title>Patient empowerment</title><p>The validation of the <italic>ARIA Allergy Diary</italic> has already been accomplished (manuscript in preparation). With the help of patient organisations (EFA: European Federation of Allergy and Airways Diseases Patients’ Associations), it will be evaluated and improved by the patients themselves.</p></sec></sec></sec><sec id="Sec16"><title>New concepts in allergic multimorbidity embedded in ARIA</title><p>The term allergic multimorbidity is more appropriate than comorbidity since the primary allergic disease is poorly known [<xref ref-type="bibr" rid="CR72">72</xref>].</p><sec id="Sec17"><title>Stratification of severe allergic and/or asthma patients</title><p>Despite the major advances in understanding allergic diseases or asthma, treatments are not effective in all patients. From a clinical perspective, implementing knowledge-based decisions on what therapeutics to use for which patients and, if relevant, in which combinations, is extremely challenging. The aspiration to provide more effective therapeutic interventions tailored to the individual remains unfulfilled because of the variable response of individuals to such interventions. Patient stratification aims at grouping patients into disease sub-groups, where the specific pathological processes involved are better defined (clinical/molecular phenotypes).</p><p>Long-term birth cohort studies are essential for understanding the life course, early predictors, risk and protective factors of allergic diseases (including asthma and rhinitis) and the complex interplay between genes and environment (including life style and socio-economic determinants) [<xref ref-type="bibr" rid="CR73">73</xref>]. MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No.: 261357; 2010–2015) attempted to better understand the complex links of allergic diseases at the clinical and mechanistic levels [<xref ref-type="bibr" rid="CR74">74</xref>–<xref ref-type="bibr" rid="CR76">76</xref>].</p><p>MeDALL identified a rare but severe allergy phenotype: polysensitized-multimorbid phenotype. Although multimorbidity is not always associated with allergy, studies in MeDALL [<xref ref-type="bibr" rid="CR77">77</xref>] on children, in the PARIS cohort at 2 years of age [<xref ref-type="bibr" rid="CR78">78</xref>], in EGEA on adults [<xref ref-type="bibr" rid="CR79">79</xref>, <xref ref-type="bibr" rid="CR80">80</xref>] (Siroux, in preparation) and patient cohorts in subjects with peanut allergy [<xref ref-type="bibr" rid="CR81">81</xref>] all show that subjects who are polysensitized and multimorbid have a very high frequency of allergic symptoms, persistent symptoms over time, more severe asthma symptoms than other phenotypes and higher total and specific IgE levels.</p><p>Taken altogether, these results indicate that asthmatic patients cannot be managed appropriately without assessing rhinitis multimorbidity and also reinforce the importance of nasal problems (rhinitis and/or rhinosinusitis) in many uncontrolled asthmatic patients [<xref ref-type="bibr" rid="CR82">82</xref>–<xref ref-type="bibr" rid="CR84">84</xref>].</p></sec><sec id="Sec18"><title>Allergic multimorbidity in old age adults</title><p>Asthma and rhinitis often start in early age and persist in most, but not all, subjects. The expected epidemic wave of asthma and rhinitis in older adults is an insufficiently recognized problem. In Europe, over 20% of adults suffer from AR and over 5% from asthma. These patients are now reaching the age of 65 years and a new health problem in older adults will be to understand, detect and manage these patients. Asthma and rhinitis in older adults have specific symptoms and treatment needs, which are different from those in younger adults. These patients also suffer from multi-morbididy with high rates of poly-pharmacy reported. Integrated Care Pathways (ICPs) for rhinitis and asthma should cover the entire life cycle.</p></sec></sec><sec id="Sec19"><title>The scaling up strategy</title><p>The EIP on AHA has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory diseases action plan of the EIP on AHA [<xref ref-type="bibr" rid="CR15">15</xref>].</p><p>There is an urgent need for scaling up strategies in order to (1) avoid fragmentation, (2) improve health care delivery across Europe, (3) speed up the implementation of good practices using existing cost-effective success stories and (4) meet the EIP on AHA objectives [<xref ref-type="bibr" rid="CR10">10</xref>].</p><sec id="Sec20"><title>Reference Site Collaborate Network (RSCN) of the EIP on AHA</title><p>The RSCN brings together all EIP on AHA Reference Sites, and Candidate Reference Sites, across Europe into a single forum. The aim is to promote cooperation and develop and promote areas of innovative good practice and solutions, which contribute to improved health and care outcomes for citizens across Europe. The hope is to develop sustainable economic growth and create jobs. Members of 13 EIP on AHA Reference Sites (2013) have agreed on the AIRWAYS ICPs concept and are co-authors of the paper published in Clinical Translational Allergy [<xref ref-type="bibr" rid="CR15">15</xref>]. A meeting of all EIP on AHA Reference Sites was co-organised by the Région LR, North England [<xref ref-type="bibr" rid="CR85">85</xref>] and the EIP on AHA Reference Site Collaborative Network to scale up AIRWAYS ICPs in all Reference Sites (October 21, 2014). 74 EIP on AHA Reference Sites have now been approved by the EU (2016). A Twinning project has also been approved by the EIP on AHA to deploy MASK in 13 Reference Sites in order to compare allergic rhinitis diagnoses by allergists in adults and older people to study phenotypes, treatments and care pathways of rhinitis.</p></sec></sec><sec id="Sec21"><title>Conclusion</title><p> ARIA has evolved from a rigorously developed guideline to a mobile technology-based implementation strategy in order to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status with the aim to reduce health and social inequalities incurred by this very common disease globally.</p></sec></body><back><glossary><title>Abbreviations</title><def-list><def-item><term>AIRWAYS ICPs</term><def><p>integrated care pathways for airway diseases</p></def></def-item><def-item><term>AR</term><def><p>allergic rhinitis</p></def></def-item><def-item><term>ARIA</term><def><p>Allergic Rhinitis and its Impact on Asthma</p></def></def-item><def-item><term>CDSS</term><def><p>Clinical Decision Support System</p></def></def-item><def-item><term>COPD</term><def><p>chronic obstructive pulmonary disease</p></def></def-item><def-item><term>DG</term><def><p>Directorate General</p></def></def-item><def-item><term>EAACI</term><def><p>European Academy of Allergy and Clinical Immunology</p></def></def-item><def-item><term>EIP on AHA</term><def><p>European Innovation Partnership on Active and Healthy Ageing</p></def></def-item><def-item><term>EU</term><def><p>European Union</p></def></def-item><def-item><term>FP</term><def><p>Framework Programme (EU)</p></def></def-item><def-item><term>GA<sup>2</sup>LEN</term><def><p>Global Allergy and Asthma European Network (FP6)</p></def></def-item><def-item><term>GARD</term><def><p>WHO Global Alliance against Chronic Respiratory Diseases</p></def></def-item><def-item><term>GRADE</term><def><p>Grading of Recommendation, Assessment, Development and Evaluation</p></def></def-item><def-item><term>HCP</term><def><p>health care professional</p></def></def-item><def-item><term>ICP</term><def><p>integrated care pathway</p></def></def-item><def-item><term>IPCRG</term><def><p>International Primary Care Respiratory Group</p></def></def-item><def-item><term>MACVIA-LR</term><def><p>Contre les Maladies Chroniques pour un Vieillissement Actif (fighting chronic diseases for active and healthy ageing)</p></def></def-item><def-item><term>MASK</term><def><p>MACVIA-ARIA Sentinel NetworK</p></def></def-item><def-item><term>MeDALL</term><def><p>Mechanisms of the Development of ALLergy (EU FP7)</p></def></def-item><def-item><term>MOH</term><def><p>Ministry of Health</p></def></def-item><def-item><term>NCD</term><def><p>non-communicable disease</p></def></def-item><def-item><term>NHS</term><def><p>National Health Service</p></def></def-item><def-item><term>RCT</term><def><p>randomized controlled trial</p></def></def-item><def-item><term>RQLQ</term><def><p>Rhinoconjunctivitis Quality of Life Questionnaire</p></def></def-item><def-item><term>RSCN</term><def><p>Reference Site Collaborative Network</p></def></def-item><def-item><term>SCUAD</term><def><p>severe chronic upper airway disease</p></def></def-item><def-item><term>VAS</term><def><p>visual analogue scale</p></def></def-item><def-item><term>WHO</term><def><p>World Health Organization</p></def></def-item></def-list></glossary><ack><title>Authors’ contributions</title><p>All authors are participating to the ARIA and AIRWAYS ICPs projects globally. All authors participated in «ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle» . All authors read and approved the final manuscript.</p><sec id="FPar1"><title>Acknowledgements</title><p>Member of the dissemination of MASK in 20 countries: J. Bousquet, P. Hellings, A. Bedbrook, C. Bachert, K.C. Bergmann, M. Bewick, C. Bindslev-Jensen, S. Bosnic-Anticevitch, D. Caimmi, P.A.M. Camargos, G.W. Canonica, T. Casale, N.H. Chavannes, A.A. Cruz, G. De Carlo, R. Dahl, P. Demoly, P. Devillier, J. Fonseca, W.J. Fokkens, T. Haahtela, J. Just, L. Klimek, P. Kuna, D. Larenas-Linnemann, M. Morais-Almeida, J. Mullol, R. Murray, R. Naclerio, R.E. O’Hehir, N.G. Papadopoulos, P. Potter, D. Ryan, B. Samolinski, H.J. Schunemann, A. Sheikh, F.E.R. Simons, P.V. Tomazic, A. Valiulis, E. Valovirta, M. Wickman, A. Yorgancioglu, T. Zuberbier, S. Arnavielle, G. De Vries, G. Dray, M. van Eerd.</p><p>Twinning of MASK in Reference Sites of the European Innovation Partnership on Active and Healthy Ageing: J. Bousquet, A. Bedbrook, M. Bewick, C. Bindslev-Jensen, C. Bucca, D. Caimmi, N.H. Chavannes, P. Demoly, J. Fonseca, N.A. Guldemond, M. Illario, P. Kuna, M. Morais-Almeida, J. Mullol, R. Murray, C. Stellato, A. Todo-Bom, M.T. Ventura, I. Young, A. Yorgancioglu, S. Arnavielle, E. Ellers, J. Farrell, R. Gerth van Wick, Z. Gutter, G. Iaccarino, M. 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