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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Coordinated international action to accelerate genome-to-phenome with FAANG, the Functional Annotation of Animal Genomes project</title><author><name sortKey="Andersson, Leif" sort="Andersson, Leif" uniqKey="Andersson L" first="Leif" last="Andersson">Leif Andersson</name><affiliation><nlm:aff id="Aff1">Science for Life Laboratory Uppsala, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, SE 751 23 Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2">Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, SE-750 07 Sweden</nlm:aff></affiliation></author><author><name sortKey="Archibald, Alan L" sort="Archibald, Alan L" uniqKey="Archibald A" first="Alan L" last="Archibald">Alan L. Archibald</name><affiliation><nlm:aff id="Aff3">The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, EH25 9RG UK</nlm:aff></affiliation></author><author><name sortKey="Bottema, Cynthia D" sort="Bottema, Cynthia D" uniqKey="Bottema C" first="Cynthia D" last="Bottema">Cynthia D. Bottema</name><affiliation><nlm:aff id="Aff4">School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371 Australia</nlm:aff></affiliation></author><author><name sortKey="Brauning, Rudiger" sort="Brauning, Rudiger" uniqKey="Brauning R" first="Rudiger" last="Brauning">Rudiger Brauning</name><affiliation><nlm:aff id="Aff5">Invermay Agricultural Centre, AgResearch Limited, Mosgiel, 9053 New Zealand</nlm:aff></affiliation></author><author><name sortKey="Burgess, Shane C" sort="Burgess, Shane C" uniqKey="Burgess S" first="Shane C" last="Burgess">Shane C. Burgess</name><affiliation><nlm:aff id="Aff6">College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85719 USA</nlm:aff></affiliation></author><author><name sortKey="Burt, Dave W" sort="Burt, Dave W" uniqKey="Burt D" first="Dave W" last="Burt">Dave W. Burt</name><affiliation><nlm:aff id="Aff3">The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, EH25 9RG UK</nlm:aff></affiliation></author><author><name sortKey="Casas, Eduardo" sort="Casas, Eduardo" uniqKey="Casas E" first="Eduardo" last="Casas">Eduardo Casas</name><affiliation><nlm:aff id="Aff7">National Animal Disease Center, United States Department of Agriculture, Agricultural Research Service, Ames, IA 50010 USA</nlm:aff></affiliation></author><author><name sortKey="Cheng, Hans H" sort="Cheng, Hans H" uniqKey="Cheng H" first="Hans H" last="Cheng">Hans H. Cheng</name><affiliation><nlm:aff id="Aff8">Avian Disease and Oncology Laboratory, United States Department of Agriculture, Agricultural Research Service, East Lansing, MI 48823 USA</nlm:aff></affiliation></author><author><name sortKey="Clarke, Laura" sort="Clarke, Laura" uniqKey="Clarke L" first="Laura" last="Clarke">Laura Clarke</name><affiliation><nlm:aff id="Aff9">European Molecular Biology Laboratory European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD UK</nlm:aff></affiliation></author><author><name sortKey="Couldrey, Christine" sort="Couldrey, Christine" uniqKey="Couldrey C" first="Christine" last="Couldrey">Christine Couldrey</name><affiliation><nlm:aff id="Aff10">Livestock Improvement Corporation, Hamilton, 3284 New Zealand</nlm:aff></affiliation></author><author><name sortKey="Dalrymple, Brian P" sort="Dalrymple, Brian P" uniqKey="Dalrymple B" first="Brian P" last="Dalrymple">Brian P. Dalrymple</name><affiliation><nlm:aff id="Aff11">Agriculture Flagship, Commonwealth Scientific and Industrial Research Organisation, St Lucia, 4067 Brisbane Australia</nlm:aff></affiliation></author><author><name sortKey="Elsik, Christine G" sort="Elsik, Christine G" uniqKey="Elsik C" first="Christine G" last="Elsik">Christine G. Elsik</name><affiliation><nlm:aff id="Aff12">Division of Animal Sciences, University of Missouri, Columbia, MO 65211 USA</nlm:aff></affiliation></author><author><name sortKey="Foissac, Sylvain" sort="Foissac, Sylvain" uniqKey="Foissac S" first="Sylvain" last="Foissac">Sylvain Foissac</name><affiliation><nlm:aff id="Aff13">UMR1388 Génétique, Physiologie et Systèmes d’Elevage (GenPhySE), French National Institute for Agricultural Research (INRA), F-31326 Castanet-Tolosan, France</nlm:aff></affiliation></author><author><name sortKey="Giuffra, Elisabetta" sort="Giuffra, Elisabetta" uniqKey="Giuffra E" first="Elisabetta" last="Giuffra">Elisabetta Giuffra</name><affiliation><nlm:aff id="Aff14">UMR1313 Génétique Animale et Biologie Intégrative (GABI), French National Institute for Agricultural Research (INRA), F-78352 Jouy-en-Josas, France</nlm:aff></affiliation></author><author><name sortKey="Groenen, Martien A" sort="Groenen, Martien A" uniqKey="Groenen M" first="Martien A" last="Groenen">Martien A. Groenen</name><affiliation><nlm:aff id="Aff15">Animal Breeding and Genomics Centre, Wageningen University, 6708 PB Wageningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hayes, Ben J" sort="Hayes, Ben J" uniqKey="Hayes B" first="Ben J" last="Hayes">Ben J. Hayes</name><affiliation><nlm:aff id="Aff16">Biosciences Research Division, Department of Environment and Primary Industries Victoria, Bundoora, 3083 Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff17">Dairy Futures Cooperative Research Centre, Bundoora, 3083 VIC Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff18">La Trobe University, Bundoora, 3086 VIC Australia</nlm:aff></affiliation></author><author><name sortKey="Huang, Lusheng S" sort="Huang, Lusheng S" uniqKey="Huang L" first="Lusheng S" last="Huang">Lusheng S. Huang</name><affiliation><nlm:aff id="Aff19">Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Jiangxi, 330029 People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Khatib, Hassan" sort="Khatib, Hassan" uniqKey="Khatib H" first="Hassan" last="Khatib">Hassan Khatib</name><affiliation><nlm:aff id="Aff20">Department of Animal Sciences, University of Wisconsin-Madison, Madison, WI 53706 USA</nlm:aff></affiliation></author><author><name sortKey="Kijas, James W" sort="Kijas, James W" uniqKey="Kijas J" first="James W" last="Kijas">James W. Kijas</name><affiliation><nlm:aff id="Aff11">Agriculture Flagship, Commonwealth Scientific and Industrial Research Organisation, St Lucia, 4067 Brisbane Australia</nlm:aff></affiliation></author><author><name sortKey="Kim, Heebal" sort="Kim, Heebal" uniqKey="Kim H" first="Heebal" last="Kim">Heebal Kim</name><affiliation><nlm:aff id="Aff21">Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Lunney, Joan K" sort="Lunney, Joan K" uniqKey="Lunney J" first="Joan K" last="Lunney">Joan K. Lunney</name><affiliation><nlm:aff id="Aff22">Animal Parasitic Diseases Laboratory, United States Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705 USA</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Fiona M" sort="Mccarthy, Fiona M" uniqKey="Mccarthy F" first="Fiona M" last="Mccarthy">Fiona M. Mccarthy</name><affiliation><nlm:aff id="Aff23">School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ 85721 USA</nlm:aff></affiliation></author><author><name sortKey="Mcewan, John C" sort="Mcewan, John C" uniqKey="Mcewan J" first="John C" last="Mcewan">John C. Mcewan</name><affiliation><nlm:aff id="Aff24">Animal Productivity Group, AgResearch Limited, Mosgiel, 9053 New Zealand</nlm:aff></affiliation></author><author><name sortKey="Moore, Stephen" sort="Moore, Stephen" uniqKey="Moore S" first="Stephen" last="Moore">Stephen Moore</name><affiliation><nlm:aff id="Aff25">Centre for Animal Science, Queensland Alliance for Agriculture & Food Innovation, University of Queensland, St Lucia, QLD 4067 Australia</nlm:aff></affiliation></author><author><name sortKey="Nanduri, Bindu" sort="Nanduri, Bindu" uniqKey="Nanduri B" first="Bindu" last="Nanduri">Bindu Nanduri</name><affiliation><nlm:aff id="Aff26">Department of Basic Sciences, College of Veterinary Medicine and Institute for Genomics, Biocomputing and Biotechnology, Mississippi State University, Mississippi, MS 39762 USA</nlm:aff></affiliation></author><author><name sortKey="Notredame, Cedric" sort="Notredame, Cedric" uniqKey="Notredame C" first="Cedric" last="Notredame">Cedric Notredame</name><affiliation><nlm:aff id="Aff27">Comparative Bioinformatics, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Palti, Yniv" sort="Palti, Yniv" uniqKey="Palti Y" first="Yniv" last="Palti">Yniv Palti</name><affiliation><nlm:aff id="Aff28">National Center for Cool and Cold Water Aquaculture, United States Department of Agriculture, Agricultural Research Service, Kearneysville, WV 25430 USA</nlm:aff></affiliation></author><author><name sortKey="Plastow, Graham S" sort="Plastow, Graham S" uniqKey="Plastow G" first="Graham S" last="Plastow">Graham S. Plastow</name><affiliation><nlm:aff id="Aff29">Livestock Gentec Centre, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2C8 Canada</nlm:aff></affiliation></author><author><name sortKey="Reecy, James M" sort="Reecy, James M" uniqKey="Reecy J" first="James M" last="Reecy">James M. Reecy</name><affiliation><nlm:aff id="Aff30">Department of Animal Science, Iowa State University, Ames, IA 50011 USA</nlm:aff></affiliation></author><author><name sortKey="Rohrer, Gary A" sort="Rohrer, Gary A" uniqKey="Rohrer G" first="Gary A" last="Rohrer">Gary A. Rohrer</name><affiliation><nlm:aff id="Aff31">US Meat Animal Research Center, United States Department of Agriculture, Agricultural Research Service, Clay Center, NE 68933 USA</nlm:aff></affiliation></author><author><name sortKey="Sarropoulou, Elena" sort="Sarropoulou, Elena" uniqKey="Sarropoulou E" first="Elena" last="Sarropoulou">Elena Sarropoulou</name><affiliation><nlm:aff id="Aff32">Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research, 71003 Heraklion, Greece</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Carl J" sort="Schmidt, Carl J" uniqKey="Schmidt C" first="Carl J" last="Schmidt">Carl J. Schmidt</name><affiliation><nlm:aff id="Aff33">Department of Animal and Food Sciences, University of Delaware, Newark, DE 19716 USA</nlm:aff></affiliation></author><author><name sortKey="Silverstein, Jeffrey" sort="Silverstein, Jeffrey" uniqKey="Silverstein J" first="Jeffrey" last="Silverstein">Jeffrey Silverstein</name><affiliation><nlm:aff id="Aff34">Animal Production and Protection, United States Department of Agriculture, Agricultural Research Service Aquaculture, Beltsville, MD 20705 USA</nlm:aff></affiliation></author><author><name sortKey="Tellam, Ross L" sort="Tellam, Ross L" uniqKey="Tellam R" first="Ross L" last="Tellam">Ross L. Tellam</name><affiliation><nlm:aff id="Aff35">CSIRO Agriculture, Commonwealth Scientific and Industrial Research Organisation, St Lucia, 4067 Australia</nlm:aff></affiliation></author><author><name sortKey="Tixier Boichard, Michele" sort="Tixier Boichard, Michele" uniqKey="Tixier Boichard M" first="Michele" last="Tixier-Boichard">Michele Tixier-Boichard</name><affiliation><nlm:aff id="Aff14">UMR1313 Génétique Animale et Biologie Intégrative (GABI), French National Institute for Agricultural Research (INRA), F-78352 Jouy-en-Josas, France</nlm:aff></affiliation></author><author><name sortKey="Tosser Klopp, Gwenola" sort="Tosser Klopp, Gwenola" uniqKey="Tosser Klopp G" first="Gwenola" last="Tosser-Klopp">Gwenola Tosser-Klopp</name><affiliation><nlm:aff id="Aff13">UMR1388 Génétique, Physiologie et Systèmes d’Elevage (GenPhySE), French National Institute for Agricultural Research (INRA), F-31326 Castanet-Tolosan, France</nlm:aff></affiliation></author><author><name sortKey="Tuggle, Christopher K" sort="Tuggle, Christopher K" uniqKey="Tuggle C" first="Christopher K" last="Tuggle">Christopher K. Tuggle</name><affiliation><nlm:aff id="Aff30">Department of Animal Science, Iowa State University, Ames, IA 50011 USA</nlm:aff></affiliation></author><author><name sortKey="Vilkki, Johanna" sort="Vilkki, Johanna" uniqKey="Vilkki J" first="Johanna" last="Vilkki">Johanna Vilkki</name><affiliation><nlm:aff id="Aff36">Green Technology, Natural Resources Institute Finland, 31600 Jokioinen, Finland</nlm:aff></affiliation></author><author><name sortKey="White, Stephen N" sort="White, Stephen N" uniqKey="White S" first="Stephen N" last="White">Stephen N. White</name><affiliation><nlm:aff id="Aff37">Animal Disease Research Unit, United States Department of Agriculture, Agricultural Research Service, Pullman, WA 99164-6630 USA</nlm:aff></affiliation><affiliation><nlm:aff id="Aff38">Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040 USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, Shuhong" sort="Zhao, Shuhong" uniqKey="Zhao S" first="Shuhong" last="Zhao">Shuhong Zhao</name><affiliation><nlm:aff id="Aff39">Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education of China, Huazhong Agricultural University, Wuhan, Hubei 430070 People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Zhou, Huaijun" sort="Zhou, Huaijun" uniqKey="Zhou H" first="Huaijun" last="Zhou">Huaijun Zhou</name><affiliation><nlm:aff id="Aff40">Department of Animal Science, University of California, Davis, CA 95616 USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25854118</idno><idno type="pmc">4373242</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373242</idno><idno type="RBID">PMC:4373242</idno><idno type="doi">10.1186/s13059-015-0622-4</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000D16</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D16</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Coordinated international action to accelerate genome-to-phenome with FAANG, the Functional Annotation of Animal Genomes project</title><author><name sortKey="Andersson, Leif" sort="Andersson, Leif" uniqKey="Andersson L" first="Leif" last="Andersson">Leif Andersson</name><affiliation><nlm:aff id="Aff1">Science for Life Laboratory Uppsala, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, SE 751 23 Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2">Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, SE-750 07 Sweden</nlm:aff></affiliation></author><author><name sortKey="Archibald, Alan L" sort="Archibald, Alan L" uniqKey="Archibald A" first="Alan L" last="Archibald">Alan L. Archibald</name><affiliation><nlm:aff id="Aff3">The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, EH25 9RG UK</nlm:aff></affiliation></author><author><name sortKey="Bottema, Cynthia D" sort="Bottema, Cynthia D" uniqKey="Bottema C" first="Cynthia D" last="Bottema">Cynthia D. Bottema</name><affiliation><nlm:aff id="Aff4">School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371 Australia</nlm:aff></affiliation></author><author><name sortKey="Brauning, Rudiger" sort="Brauning, Rudiger" uniqKey="Brauning R" first="Rudiger" last="Brauning">Rudiger Brauning</name><affiliation><nlm:aff id="Aff5">Invermay Agricultural Centre, AgResearch Limited, Mosgiel, 9053 New Zealand</nlm:aff></affiliation></author><author><name sortKey="Burgess, Shane C" sort="Burgess, Shane C" uniqKey="Burgess S" first="Shane C" last="Burgess">Shane C. Burgess</name><affiliation><nlm:aff id="Aff6">College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85719 USA</nlm:aff></affiliation></author><author><name sortKey="Burt, Dave W" sort="Burt, Dave W" uniqKey="Burt D" first="Dave W" last="Burt">Dave W. Burt</name><affiliation><nlm:aff id="Aff3">The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, EH25 9RG UK</nlm:aff></affiliation></author><author><name sortKey="Casas, Eduardo" sort="Casas, Eduardo" uniqKey="Casas E" first="Eduardo" last="Casas">Eduardo Casas</name><affiliation><nlm:aff id="Aff7">National Animal Disease Center, United States Department of Agriculture, Agricultural Research Service, Ames, IA 50010 USA</nlm:aff></affiliation></author><author><name sortKey="Cheng, Hans H" sort="Cheng, Hans H" uniqKey="Cheng H" first="Hans H" last="Cheng">Hans H. Cheng</name><affiliation><nlm:aff id="Aff8">Avian Disease and Oncology Laboratory, United States Department of Agriculture, Agricultural Research Service, East Lansing, MI 48823 USA</nlm:aff></affiliation></author><author><name sortKey="Clarke, Laura" sort="Clarke, Laura" uniqKey="Clarke L" first="Laura" last="Clarke">Laura Clarke</name><affiliation><nlm:aff id="Aff9">European Molecular Biology Laboratory European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD UK</nlm:aff></affiliation></author><author><name sortKey="Couldrey, Christine" sort="Couldrey, Christine" uniqKey="Couldrey C" first="Christine" last="Couldrey">Christine Couldrey</name><affiliation><nlm:aff id="Aff10">Livestock Improvement Corporation, Hamilton, 3284 New Zealand</nlm:aff></affiliation></author><author><name sortKey="Dalrymple, Brian P" sort="Dalrymple, Brian P" uniqKey="Dalrymple B" first="Brian P" last="Dalrymple">Brian P. Dalrymple</name><affiliation><nlm:aff id="Aff11">Agriculture Flagship, Commonwealth Scientific and Industrial Research Organisation, St Lucia, 4067 Brisbane Australia</nlm:aff></affiliation></author><author><name sortKey="Elsik, Christine G" sort="Elsik, Christine G" uniqKey="Elsik C" first="Christine G" last="Elsik">Christine G. Elsik</name><affiliation><nlm:aff id="Aff12">Division of Animal Sciences, University of Missouri, Columbia, MO 65211 USA</nlm:aff></affiliation></author><author><name sortKey="Foissac, Sylvain" sort="Foissac, Sylvain" uniqKey="Foissac S" first="Sylvain" last="Foissac">Sylvain Foissac</name><affiliation><nlm:aff id="Aff13">UMR1388 Génétique, Physiologie et Systèmes d’Elevage (GenPhySE), French National Institute for Agricultural Research (INRA), F-31326 Castanet-Tolosan, France</nlm:aff></affiliation></author><author><name sortKey="Giuffra, Elisabetta" sort="Giuffra, Elisabetta" uniqKey="Giuffra E" first="Elisabetta" last="Giuffra">Elisabetta Giuffra</name><affiliation><nlm:aff id="Aff14">UMR1313 Génétique Animale et Biologie Intégrative (GABI), French National Institute for Agricultural Research (INRA), F-78352 Jouy-en-Josas, France</nlm:aff></affiliation></author><author><name sortKey="Groenen, Martien A" sort="Groenen, Martien A" uniqKey="Groenen M" first="Martien A" last="Groenen">Martien A. Groenen</name><affiliation><nlm:aff id="Aff15">Animal Breeding and Genomics Centre, Wageningen University, 6708 PB Wageningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hayes, Ben J" sort="Hayes, Ben J" uniqKey="Hayes B" first="Ben J" last="Hayes">Ben J. Hayes</name><affiliation><nlm:aff id="Aff16">Biosciences Research Division, Department of Environment and Primary Industries Victoria, Bundoora, 3083 Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff17">Dairy Futures Cooperative Research Centre, Bundoora, 3083 VIC Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff18">La Trobe University, Bundoora, 3086 VIC Australia</nlm:aff></affiliation></author><author><name sortKey="Huang, Lusheng S" sort="Huang, Lusheng S" uniqKey="Huang L" first="Lusheng S" last="Huang">Lusheng S. Huang</name><affiliation><nlm:aff id="Aff19">Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Jiangxi, 330029 People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Khatib, Hassan" sort="Khatib, Hassan" uniqKey="Khatib H" first="Hassan" last="Khatib">Hassan Khatib</name><affiliation><nlm:aff id="Aff20">Department of Animal Sciences, University of Wisconsin-Madison, Madison, WI 53706 USA</nlm:aff></affiliation></author><author><name sortKey="Kijas, James W" sort="Kijas, James W" uniqKey="Kijas J" first="James W" last="Kijas">James W. Kijas</name><affiliation><nlm:aff id="Aff11">Agriculture Flagship, Commonwealth Scientific and Industrial Research Organisation, St Lucia, 4067 Brisbane Australia</nlm:aff></affiliation></author><author><name sortKey="Kim, Heebal" sort="Kim, Heebal" uniqKey="Kim H" first="Heebal" last="Kim">Heebal Kim</name><affiliation><nlm:aff id="Aff21">Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Lunney, Joan K" sort="Lunney, Joan K" uniqKey="Lunney J" first="Joan K" last="Lunney">Joan K. Lunney</name><affiliation><nlm:aff id="Aff22">Animal Parasitic Diseases Laboratory, United States Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705 USA</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Fiona M" sort="Mccarthy, Fiona M" uniqKey="Mccarthy F" first="Fiona M" last="Mccarthy">Fiona M. Mccarthy</name><affiliation><nlm:aff id="Aff23">School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ 85721 USA</nlm:aff></affiliation></author><author><name sortKey="Mcewan, John C" sort="Mcewan, John C" uniqKey="Mcewan J" first="John C" last="Mcewan">John C. Mcewan</name><affiliation><nlm:aff id="Aff24">Animal Productivity Group, AgResearch Limited, Mosgiel, 9053 New Zealand</nlm:aff></affiliation></author><author><name sortKey="Moore, Stephen" sort="Moore, Stephen" uniqKey="Moore S" first="Stephen" last="Moore">Stephen Moore</name><affiliation><nlm:aff id="Aff25">Centre for Animal Science, Queensland Alliance for Agriculture & Food Innovation, University of Queensland, St Lucia, QLD 4067 Australia</nlm:aff></affiliation></author><author><name sortKey="Nanduri, Bindu" sort="Nanduri, Bindu" uniqKey="Nanduri B" first="Bindu" last="Nanduri">Bindu Nanduri</name><affiliation><nlm:aff id="Aff26">Department of Basic Sciences, College of Veterinary Medicine and Institute for Genomics, Biocomputing and Biotechnology, Mississippi State University, Mississippi, MS 39762 USA</nlm:aff></affiliation></author><author><name sortKey="Notredame, Cedric" sort="Notredame, Cedric" uniqKey="Notredame C" first="Cedric" last="Notredame">Cedric Notredame</name><affiliation><nlm:aff id="Aff27">Comparative Bioinformatics, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Palti, Yniv" sort="Palti, Yniv" uniqKey="Palti Y" first="Yniv" last="Palti">Yniv Palti</name><affiliation><nlm:aff id="Aff28">National Center for Cool and Cold Water Aquaculture, United States Department of Agriculture, Agricultural Research Service, Kearneysville, WV 25430 USA</nlm:aff></affiliation></author><author><name sortKey="Plastow, Graham S" sort="Plastow, Graham S" uniqKey="Plastow G" first="Graham S" last="Plastow">Graham S. Plastow</name><affiliation><nlm:aff id="Aff29">Livestock Gentec Centre, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2C8 Canada</nlm:aff></affiliation></author><author><name sortKey="Reecy, James M" sort="Reecy, James M" uniqKey="Reecy J" first="James M" last="Reecy">James M. Reecy</name><affiliation><nlm:aff id="Aff30">Department of Animal Science, Iowa State University, Ames, IA 50011 USA</nlm:aff></affiliation></author><author><name sortKey="Rohrer, Gary A" sort="Rohrer, Gary A" uniqKey="Rohrer G" first="Gary A" last="Rohrer">Gary A. Rohrer</name><affiliation><nlm:aff id="Aff31">US Meat Animal Research Center, United States Department of Agriculture, Agricultural Research Service, Clay Center, NE 68933 USA</nlm:aff></affiliation></author><author><name sortKey="Sarropoulou, Elena" sort="Sarropoulou, Elena" uniqKey="Sarropoulou E" first="Elena" last="Sarropoulou">Elena Sarropoulou</name><affiliation><nlm:aff id="Aff32">Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research, 71003 Heraklion, Greece</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Carl J" sort="Schmidt, Carl J" uniqKey="Schmidt C" first="Carl J" last="Schmidt">Carl J. Schmidt</name><affiliation><nlm:aff id="Aff33">Department of Animal and Food Sciences, University of Delaware, Newark, DE 19716 USA</nlm:aff></affiliation></author><author><name sortKey="Silverstein, Jeffrey" sort="Silverstein, Jeffrey" uniqKey="Silverstein J" first="Jeffrey" last="Silverstein">Jeffrey Silverstein</name><affiliation><nlm:aff id="Aff34">Animal Production and Protection, United States Department of Agriculture, Agricultural Research Service Aquaculture, Beltsville, MD 20705 USA</nlm:aff></affiliation></author><author><name sortKey="Tellam, Ross L" sort="Tellam, Ross L" uniqKey="Tellam R" first="Ross L" last="Tellam">Ross L. Tellam</name><affiliation><nlm:aff id="Aff35">CSIRO Agriculture, Commonwealth Scientific and Industrial Research Organisation, St Lucia, 4067 Australia</nlm:aff></affiliation></author><author><name sortKey="Tixier Boichard, Michele" sort="Tixier Boichard, Michele" uniqKey="Tixier Boichard M" first="Michele" last="Tixier-Boichard">Michele Tixier-Boichard</name><affiliation><nlm:aff id="Aff14">UMR1313 Génétique Animale et Biologie Intégrative (GABI), French National Institute for Agricultural Research (INRA), F-78352 Jouy-en-Josas, France</nlm:aff></affiliation></author><author><name sortKey="Tosser Klopp, Gwenola" sort="Tosser Klopp, Gwenola" uniqKey="Tosser Klopp G" first="Gwenola" last="Tosser-Klopp">Gwenola Tosser-Klopp</name><affiliation><nlm:aff id="Aff13">UMR1388 Génétique, Physiologie et Systèmes d’Elevage (GenPhySE), French National Institute for Agricultural Research (INRA), F-31326 Castanet-Tolosan, France</nlm:aff></affiliation></author><author><name sortKey="Tuggle, Christopher K" sort="Tuggle, Christopher K" uniqKey="Tuggle C" first="Christopher K" last="Tuggle">Christopher K. Tuggle</name><affiliation><nlm:aff id="Aff30">Department of Animal Science, Iowa State University, Ames, IA 50011 USA</nlm:aff></affiliation></author><author><name sortKey="Vilkki, Johanna" sort="Vilkki, Johanna" uniqKey="Vilkki J" first="Johanna" last="Vilkki">Johanna Vilkki</name><affiliation><nlm:aff id="Aff36">Green Technology, Natural Resources Institute Finland, 31600 Jokioinen, Finland</nlm:aff></affiliation></author><author><name sortKey="White, Stephen N" sort="White, Stephen N" uniqKey="White S" first="Stephen N" last="White">Stephen N. White</name><affiliation><nlm:aff id="Aff37">Animal Disease Research Unit, United States Department of Agriculture, Agricultural Research Service, Pullman, WA 99164-6630 USA</nlm:aff></affiliation><affiliation><nlm:aff id="Aff38">Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040 USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, Shuhong" sort="Zhao, Shuhong" uniqKey="Zhao S" first="Shuhong" last="Zhao">Shuhong Zhao</name><affiliation><nlm:aff id="Aff39">Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education of China, Huazhong Agricultural University, Wuhan, Hubei 430070 People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Zhou, Huaijun" sort="Zhou, Huaijun" uniqKey="Zhou H" first="Huaijun" last="Zhou">Huaijun Zhou</name><affiliation><nlm:aff id="Aff40">Department of Animal Science, University of California, Davis, CA 95616 USA</nlm:aff></affiliation></author></analytic><series><title level="j">Genome Biology</title><idno type="ISSN">1465-6906</idno><idno type="eISSN">1465-6914</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We describe the organization of a nascent international effort, the Functional Annotation of Animal Genomes (FAANG) project, whose aim is to produce comprehensive maps of functional elements in the genomes of domesticated animal species.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13059-015-0622-4) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Andersson, L" uniqKey="Andersson L">L 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Genome Biol</journal-id><journal-title-group><journal-title>Genome Biology</journal-title></journal-title-group><issn pub-type="ppub">1465-6906</issn><issn pub-type="epub">1465-6914</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25854118</article-id><article-id pub-id-type="pmc">4373242</article-id><article-id pub-id-type="publisher-id">622</article-id><article-id pub-id-type="doi">10.1186/s13059-015-0622-4</article-id><article-categories><subj-group subj-group-type="heading"><subject>Open Letter</subject></subj-group></article-categories><title-group><article-title>Coordinated international action to accelerate genome-to-phenome with FAANG, the Functional Annotation of Animal Genomes project</article-title></title-group><contrib-group><contrib contrib-type="author"><collab>The FAANG Consortium</collab></contrib><contrib contrib-type="author"><name><surname>Andersson</surname><given-names>Leif</given-names></name><address><email>Leif.Andersson@imbim.uu.se</email></address><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Archibald</surname><given-names>Alan L</given-names></name><address><email>alan.archibald@roslin.ed.ac.uk</email></address><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author"><name><surname>Bottema</surname><given-names>Cynthia D</given-names></name><address><email>cynthia.bottema@adelaide.edu.au</email></address><xref ref-type="aff" rid="Aff4"></xref></contrib><contrib contrib-type="author"><name><surname>Brauning</surname><given-names>Rudiger</given-names></name><address><email>Rudiger.Brauning@agresearch.co.nz</email></address><xref ref-type="aff" rid="Aff5"></xref></contrib><contrib 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rid="Aff9"></xref></contrib><contrib contrib-type="author"><name><surname>Couldrey</surname><given-names>Christine</given-names></name><address><email>Christine.Couldrey@agresearch.co.nz</email></address><xref ref-type="aff" rid="Aff10"></xref></contrib><contrib contrib-type="author"><name><surname>Dalrymple</surname><given-names>Brian P</given-names></name><address><email>Brian.Dalrymple@csiro.au</email></address><xref ref-type="aff" rid="Aff11"></xref></contrib><contrib contrib-type="author"><name><surname>Elsik</surname><given-names>Christine G</given-names></name><address><email>elsikc@missouri.edu</email></address><xref ref-type="aff" rid="Aff12"></xref></contrib><contrib contrib-type="author"><name><surname>Foissac</surname><given-names>Sylvain</given-names></name><address><email>Sylvain.Foissac@toulouse.inra.fr</email></address><xref ref-type="aff" rid="Aff13"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Giuffra</surname><given-names>Elisabetta</given-names></name><address><email>elisabetta.giuffra@jouy.inra.fr</email></address><xref ref-type="aff" rid="Aff14"></xref></contrib><contrib contrib-type="author"><name><surname>Groenen</surname><given-names>Martien A</given-names></name><address><email>martien.groenen@wur.nl</email></address><xref ref-type="aff" rid="Aff15"></xref></contrib><contrib contrib-type="author"><name><surname>Hayes</surname><given-names>Ben J</given-names></name><address><email>ben.hayes@dpi.vic.gov.au</email></address><xref ref-type="aff" rid="Aff16"></xref><xref ref-type="aff" rid="Aff17"></xref><xref ref-type="aff" rid="Aff18"></xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>LuSheng S</given-names></name><address><email>Lushenghuang@hotmail.com</email></address><xref ref-type="aff" rid="Aff19"></xref></contrib><contrib contrib-type="author"><name><surname>Khatib</surname><given-names>Hassan</given-names></name><address><email>hkhatib@wisc.edu</email></address><xref ref-type="aff" rid="Aff20"></xref></contrib><contrib contrib-type="author"><name><surname>Kijas</surname><given-names>James W</given-names></name><address><email>James.Kijas@csiro.au</email></address><xref ref-type="aff" rid="Aff11"></xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Heebal</given-names></name><address><email>heebal@snu.ac.kr</email></address><xref ref-type="aff" rid="Aff21"></xref></contrib><contrib contrib-type="author"><name><surname>Lunney</surname><given-names>Joan K</given-names></name><address><email>Joan.Lunney@ars.usda.gov</email></address><xref ref-type="aff" rid="Aff22"></xref></contrib><contrib contrib-type="author"><name><surname>McCarthy</surname><given-names>Fiona M</given-names></name><address><email>fionamcc@email.arizona.edu</email></address><xref ref-type="aff" rid="Aff23"></xref></contrib><contrib contrib-type="author"><name><surname>McEwan</surname><given-names>John C</given-names></name><address><email>john.mcewan@agresearch.co.nz</email></address><xref ref-type="aff" rid="Aff24"></xref></contrib><contrib contrib-type="author"><name><surname>Moore</surname><given-names>Stephen</given-names></name><address><email>s.moore3@uq.edu.au</email></address><xref ref-type="aff" rid="Aff25"></xref></contrib><contrib contrib-type="author"><name><surname>Nanduri</surname><given-names>Bindu</given-names></name><address><email>bnanduri@cvm.msstate.edu</email></address><xref ref-type="aff" rid="Aff26"></xref></contrib><contrib contrib-type="author"><name><surname>Notredame</surname><given-names>Cedric</given-names></name><address><email>cedric.notredame@crg.eu</email></address><xref ref-type="aff" rid="Aff27"></xref></contrib><contrib contrib-type="author"><name><surname>Palti</surname><given-names>Yniv</given-names></name><address><email>yniv.palti@ars.usda.gov</email></address><xref ref-type="aff" rid="Aff28"></xref></contrib><contrib contrib-type="author"><name><surname>Plastow</surname><given-names>Graham S</given-names></name><address><email>plastow@ualberta.ca</email></address><xref ref-type="aff" rid="Aff29"></xref></contrib><contrib contrib-type="author"><name><surname>Reecy</surname><given-names>James M</given-names></name><address><email>jreecy@iastate.edu</email></address><xref ref-type="aff" rid="Aff30"></xref></contrib><contrib contrib-type="author"><name><surname>Rohrer</surname><given-names>Gary A</given-names></name><address><email>Gary.Rohrer@ars.usda.gov</email></address><xref ref-type="aff" rid="Aff31"></xref></contrib><contrib contrib-type="author"><name><surname>Sarropoulou</surname><given-names>Elena</given-names></name><address><email>sarris@hcmr.gr</email></address><xref ref-type="aff" rid="Aff32"></xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Carl J</given-names></name><address><email>schmidtc@UDel.Edu</email></address><xref ref-type="aff" rid="Aff33"></xref></contrib><contrib contrib-type="author"><name><surname>Silverstein</surname><given-names>Jeffrey</given-names></name><address><email>Jeff.Silverstein@ars.usda.gov</email></address><xref ref-type="aff" rid="Aff34"></xref></contrib><contrib contrib-type="author"><name><surname>Tellam</surname><given-names>Ross L</given-names></name><address><email>Ross.Tellam@csiro.au</email></address><xref ref-type="aff" rid="Aff35"></xref></contrib><contrib contrib-type="author"><name><surname>Tixier-Boichard</surname><given-names>Michele</given-names></name><address><email>Michele.Boichard@jouy.inra.fr</email></address><xref ref-type="aff" rid="Aff14"></xref></contrib><contrib contrib-type="author"><name><surname>Tosser-Klopp</surname><given-names>Gwenola</given-names></name><address><email>gwenola.tosser@toulouse.inra.fr</email></address><xref ref-type="aff" rid="Aff13"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Tuggle</surname><given-names>Christopher K</given-names></name><address><email>cktuggle@iastate.edu</email></address><xref ref-type="aff" rid="Aff30"></xref></contrib><contrib contrib-type="author"><name><surname>Vilkki</surname><given-names>Johanna</given-names></name><address><email>johanna.vilkki@luke.fi</email></address><xref ref-type="aff" rid="Aff36"></xref></contrib><contrib contrib-type="author"><name><surname>White</surname><given-names>Stephen N</given-names></name><address><email>stephen.white@ars.usda.gov</email></address><xref ref-type="aff" rid="Aff37"></xref><xref ref-type="aff" rid="Aff38"></xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Shuhong</given-names></name><address><email>shzhao@mail.hzau.edu.cn</email></address><xref ref-type="aff" rid="Aff39"></xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Huaijun</given-names></name><address><email>hzhou@ucdavis.edu</email></address><xref ref-type="aff" rid="Aff40"></xref></contrib><aff id="Aff1"><label></label>Science for Life Laboratory Uppsala, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, SE 751 23 Sweden</aff><aff id="Aff2"><label></label>Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, SE-750 07 Sweden</aff><aff id="Aff3"><label></label>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, EH25 9RG UK</aff><aff id="Aff4"><label></label>School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371 Australia</aff><aff id="Aff5"><label></label>Invermay Agricultural Centre, AgResearch Limited, Mosgiel, 9053 New Zealand</aff><aff id="Aff6"><label></label>College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85719 USA</aff><aff id="Aff7"><label></label>National Animal Disease Center, United States Department of Agriculture, Agricultural Research Service, Ames, IA 50010 USA</aff><aff id="Aff8"><label></label>Avian Disease and Oncology Laboratory, United States Department of Agriculture, Agricultural Research Service, East Lansing, MI 48823 USA</aff><aff id="Aff9"><label></label>European Molecular Biology Laboratory European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD UK</aff><aff id="Aff10"><label></label>Livestock Improvement Corporation, Hamilton, 3284 New Zealand</aff><aff id="Aff11"><label></label>Agriculture Flagship, Commonwealth Scientific and Industrial Research Organisation, St Lucia, 4067 Brisbane Australia</aff><aff id="Aff12"><label></label>Division of Animal Sciences, University of Missouri, Columbia, MO 65211 USA</aff><aff id="Aff13"><label></label>UMR1388 Génétique, Physiologie et Systèmes d’Elevage (GenPhySE), French National Institute for Agricultural Research (INRA), F-31326 Castanet-Tolosan, France</aff><aff id="Aff14"><label></label>UMR1313 Génétique Animale et Biologie Intégrative (GABI), French National Institute for Agricultural Research (INRA), F-78352 Jouy-en-Josas, France</aff><aff id="Aff15"><label></label>Animal Breeding and Genomics Centre, Wageningen University, 6708 PB Wageningen, The Netherlands</aff><aff id="Aff16"><label></label>Biosciences Research Division, Department of Environment and Primary Industries Victoria, Bundoora, 3083 Australia</aff><aff id="Aff17"><label></label>Dairy Futures Cooperative Research Centre, Bundoora, 3083 VIC Australia</aff><aff id="Aff18"><label></label>La Trobe University, Bundoora, 3086 VIC Australia</aff><aff id="Aff19"><label></label>Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Jiangxi, 330029 People’s Republic of China</aff><aff id="Aff20"><label></label>Department of Animal Sciences, University of Wisconsin-Madison, Madison, WI 53706 USA</aff><aff id="Aff21"><label></label>Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea</aff><aff id="Aff22"><label></label>Animal Parasitic Diseases Laboratory, United States Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705 USA</aff><aff id="Aff23"><label></label>School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ 85721 USA</aff><aff id="Aff24"><label></label>Animal Productivity Group, AgResearch Limited, Mosgiel, 9053 New Zealand</aff><aff id="Aff25"><label></label>Centre for Animal Science, Queensland Alliance for Agriculture & Food Innovation, University of Queensland, St Lucia, QLD 4067 Australia</aff><aff id="Aff26"><label></label>Department of Basic Sciences, College of Veterinary Medicine and Institute for Genomics, Biocomputing and Biotechnology, Mississippi State University, Mississippi, MS 39762 USA</aff><aff id="Aff27"><label></label>Comparative Bioinformatics, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain</aff><aff id="Aff28"><label></label>National Center for Cool and Cold Water Aquaculture, United States Department of Agriculture, Agricultural Research Service, Kearneysville, WV 25430 USA</aff><aff id="Aff29"><label></label>Livestock Gentec Centre, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2C8 Canada</aff><aff id="Aff30"><label></label>Department of Animal Science, Iowa State University, Ames, IA 50011 USA</aff><aff id="Aff31"><label></label>US Meat Animal Research Center, United States Department of Agriculture, Agricultural Research Service, Clay Center, NE 68933 USA</aff><aff id="Aff32"><label></label>Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research, 71003 Heraklion, Greece</aff><aff id="Aff33"><label></label>Department of Animal and Food Sciences, University of Delaware, Newark, DE 19716 USA</aff><aff id="Aff34"><label></label>Animal Production and Protection, United States Department of Agriculture, Agricultural Research Service Aquaculture, Beltsville, MD 20705 USA</aff><aff id="Aff35"><label></label>CSIRO Agriculture, Commonwealth Scientific and Industrial Research Organisation, St Lucia, 4067 Australia</aff><aff id="Aff36"><label></label>Green Technology, Natural Resources Institute Finland, 31600 Jokioinen, Finland</aff><aff id="Aff37"><label></label>Animal Disease Research Unit, United States Department of Agriculture, Agricultural Research Service, Pullman, WA 99164-6630 USA</aff><aff id="Aff38"><label></label>Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040 USA</aff><aff id="Aff39"><label></label>Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education of China, Huazhong Agricultural University, Wuhan, Hubei 430070 People’s Republic of China</aff><aff id="Aff40"><label></label>Department of Animal Science, University of California, Davis, CA 95616 USA</aff></contrib-group><pub-date pub-type="epub"><day>25</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>25</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="ppub"><year>2015</year></pub-date><volume>16</volume><issue>1</issue><elocation-id>57</elocation-id><permissions><copyright-statement>© Andersson et al.; licensee BioMed Central. 2015</copyright-statement><license license-type="open-access"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><p>We describe the organization of a nascent international effort, the Functional Annotation of Animal Genomes (FAANG) project, whose aim is to produce comprehensive maps of functional elements in the genomes of domesticated animal species.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13059-015-0622-4) contains supplementary material, which is available to authorized users.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2015</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec id="Sec1"><title>Predictive biology: from sequence to consequence</title><p>Most phenotypes are complex and quantitative in nature, and a major goal of biological research lies in using genome information to predict such complex outcomes, whether it is the efficacy of a drug, susceptibility to cancer, or the performance of the daughters of an elite dairy bull. Many of the recent advances in biology have been driven by genome sequence information. The capability to sequence and decipher the instructions encoded in complex animal genomes quickly and at modest cost is now well established. The next challenge is to be able to read the subtlety and complexity of these instructions and to predict the resulting phenotypes, that is, to predict the consequences encoded in sequences. While significant progress in functional genome annotation has been made using various human cell types [<xref ref-type="bibr" rid="CR1">1</xref>], we argue that filling the genotype-to-phenotype gap requires functional genome annotation of species with substantial phenotype information.</p></sec><sec id="Sec2"><title>The unique value of domesticated animal species for accelerating our understanding of genomes and phenomes</title><p>Research on domesticated animals has important scientific and socioeconomic impacts, including contributing to medical research, improving the health and welfare of companion animals, and underpinning improvements in the animal sector of agriculture. A key to these impacts is the wealth of genetic and phenotypic diversity among domesticated animals, coupled with research to elucidate the genetic architecture underlying quantitative traits.</p><sec id="Sec3"><title>From association to causation: pioneering success in domesticated species</title><p>Deep pedigrees with extensive phenotypic records, genetic and phenotypic diversity shaped by natural and artificial selection, and the latest molecular genomics and statistical tools provide an opportunity to understand the relationship between genotype and phenotype in outbred domesticated and farmed animal species [<xref ref-type="bibr" rid="CR2">2</xref>]. We cite four examples of past successes. First, the identification of a single base-pair change as the causal genetic variant for the complex callipyge muscle hypertrophy phenotype in sheep [<xref ref-type="bibr" rid="CR3">3</xref>]. Second, the finding that a single nucleotide change in the 3’-untranslated region of the sheep myostatin gene creates a new microRNA binding site that decreases myostatin protein expression [<xref ref-type="bibr" rid="CR4">4</xref>]. Third, the identification of a single nucleotide change in an <italic>IGF2</italic> intron that is the causal mutation for a quantitative trait locus with effects on muscle growth and fat depth in pigs [<xref ref-type="bibr" rid="CR5">5</xref>]. Finally, the finding that a premature stop codon in the <italic>DMRT3</italic> gene has a major effect on the pattern of locomotion in horses [<xref ref-type="bibr" rid="CR6">6</xref>]. Much of the genetic variation underlying quantitative traits is likely to be located in regulatory sequences [<xref ref-type="bibr" rid="CR7">7</xref>], and two of the examples cited above [<xref ref-type="bibr" rid="CR3">3</xref>,<xref ref-type="bibr" rid="CR5">5</xref>] demonstrate the importance of epigenetic mechanisms in determining complex phenotypes.</p></sec><sec id="Sec4"><title>Evolution, selection, adaptation</title><p>The study of genomes of domesticated animals provides insight into evolution, adaptation and genetic selection. Domesticated and farmed animals represent a wide evolutionary spectrum from bees, through shellfish, fish, birds and mammals, and analyses of their genomes have revealed relationships between sequence and function [<xref ref-type="bibr" rid="CR8">8</xref>-<xref ref-type="bibr" rid="CR12">12</xref>]. Genome-wide analysis of domesticated species and their putative wild ancestors has shed light on domestication [<xref ref-type="bibr" rid="CR8">8</xref>,<xref ref-type="bibr" rid="CR13">13</xref>-<xref ref-type="bibr" rid="CR15">15</xref>]. Importantly, the footprint of artificial selection can also be detected and provides glimpses of the relationship between sequence and selected phenotypes [<xref ref-type="bibr" rid="CR16">16</xref>-<xref ref-type="bibr" rid="CR18">18</xref>].</p></sec><sec id="Sec5"><title>Biomedical models</title><p>Several domesticated animal species are widely used to model human biology, including the pig, sheep, chicken and dog. However, while coding sequence variants can be major determinants of phenotype as exemplified by many monogenic inherited diseases, attempts to recapitulate the disease phenotype in genetically modified mice often fail [<xref ref-type="bibr" rid="CR19">19</xref>]. This lack of accurate translation to human biology demonstrates the need for a better understanding of the genotype-to-phenotype relationship [<xref ref-type="bibr" rid="CR20">20</xref>], potentially through the use of additional species that better approximate human physiology [<xref ref-type="bibr" rid="CR21">21</xref>].</p></sec><sec id="Sec6"><title>Modeling animals as systems: success in phenotypic selection but little mechanistic knowledge</title><p>Animals are complex systems in which predicting phenotype from genotype (sequence) is challenging. However, quantitative geneticists and animal breeders have been remarkably successful at developing statistical animal models that are effective predictors of future performance [<xref ref-type="bibr" rid="CR22">22</xref>]. The accuracy of these models has been increased by using high-density single nucleotide polymorphism genotypes [<xref ref-type="bibr" rid="CR22">22</xref>,<xref ref-type="bibr" rid="CR23">23</xref>]. Further improvements can be achieved through the use of genome sequence data [<xref ref-type="bibr" rid="CR24">24</xref>-<xref ref-type="bibr" rid="CR26">26</xref>] and by adding knowledge of the likely effects of the sequence variants, whether coding or regulatory [<xref ref-type="bibr" rid="CR27">27</xref>]. However, while artificial selection acting on the enormous underlying genetic diversity has made improvements in traits of economic importance, there is little understanding of the biological mechanisms underpinning such phenotypes.</p></sec></sec><sec id="Sec7"><title>Recent progress in animal genome sequencing provides new opportunities in elucidating the genotype-to-phenotype connection</title><p>Coordinated genome-wide identification of functional elements in multiple species would be an invaluable resource for the dissection of genotype-to-phenotype relationships. The evolutionary breadth of the Encyclopedia of DNA Elements (ENCODE) projects has been expanded from humans to classical model species (mouse [<xref ref-type="bibr" rid="CR28">28</xref>,<xref ref-type="bibr" rid="CR29">29</xref>], <italic>Drosophila</italic> [<xref ref-type="bibr" rid="CR30">30</xref>], <italic>Caenorhabditis elegans</italic> [<xref ref-type="bibr" rid="CR31">31</xref>] and zebrafish [<xref ref-type="bibr" rid="CR32">32</xref>]). However, transcriptome complexity differs significantly between species [<xref ref-type="bibr" rid="CR33">33</xref>]; in general, extrapolation of regulatory sequence data across species has not proven useful [<xref ref-type="bibr" rid="CR34">34</xref>]. In line with previous evidence, the mouse ENCODE project provided multiple lines of evidence that gene expression and its underlying regulatory programs have substantially diverged between the human and mouse lineages, although a subset of core regulatory programs is largely conserved [<xref ref-type="bibr" rid="CR29">29</xref>]. Thus, additional sampling of species, especially those with deep phenotypic records, is needed to fully understand how these functional elements define the timing, amplitude and response to developmental and environmental cues [<xref ref-type="bibr" rid="CR35">35</xref>].</p><p>A prerequisite for mapping functional elements is a reference genome assembly. Reference genome sequences have been established for a range of important domesticated animals (Additional file <xref rid="MOESM1" ref-type="media">1</xref>). However, the annotation of these genome sequences is currently limited to gene models deduced using RNA expression and DNA variation data. Thus, in comparison to human and mouse, the complexity of the transcriptomes in domesticated animals is inadequately characterized. This is exacerbated by the fact that while 70% to 90% of the coding elements can be readily identified, there is little information on noncoding genes, and even less on the regulatory sequences that often underlie complex traits.</p><p>The ENCODE and epigenome consortia have already demonstrated that improved functional annotation is most efficiently delivered collaboratively [<xref ref-type="bibr" rid="CR1">1</xref>,<xref ref-type="bibr" rid="CR28">28</xref>-<xref ref-type="bibr" rid="CR32">32</xref>,<xref ref-type="bibr" rid="CR36">36</xref>]. Thus, in combination with filling the gap in deriving phenotype from genotype described above, this advantage is a strong motivation for an internationally coordinated Functional Annotation of Animal Genomes (FAANG) project as proposed below.</p></sec><sec id="Sec8"><title>The FAANG Consortium</title><p>In January 2014, a workshop was convened by the Animal Biotechnology Working Group of the EU-US Biotechnology Research Task Force in San Diego, CA, USA. During this workshop, and in subsequent discussions, basic principles were laid out to establish the FAANG Consortium and to outline plans for a FAANG project (see below). The aim of the Consortium is to produce comprehensive maps of functional elements in the genomes of domesticated animal species based on common standardized protocols and procedures. The FAANG Consortium signatories are committing to work within the FAANG community to define and improve experimental, metadata and bioinformatics standards; ensure that experiments conducted to produce functional annotation adhere to these standards; and release all the experimental and metadata in an open access manner, rapidly and before publication, in accordance with the Toronto Statement [<xref ref-type="bibr" rid="CR37">37</xref>].</p><p>A web portal has been established to consolidate and distribute information on the FAANG Consortium (standardized protocols and pipelines of analysis, data summaries, and publications) and as a means for new participants to join the Consortium [<xref ref-type="bibr" rid="CR38">38</xref>]. Additional details on the FAANG Consortium, including current membership and goals, can also be found on the web portal.</p></sec><sec id="Sec9"><title>Delivering the FAANG project</title><p>The human ENCODE project cost over $150 million and involved at least 442 scientists in 32 institutions around the world. Lessons learned from this project and advances in high-throughput technologies have transformed the ease and efficiency with which this type of project can be executed. A coordinated effort to generate data from similar tissues using common core assays to minimize redundancy and leverage existing activity will enable the FAANG project to make significant progress in a cost-effective manner. ENCODE-type data will be generated at a fraction of the original cost and in a distributed way, thanks to the modular nature of experiments.</p><sec id="Sec10"><title>Parallel sample and data collection from species ready to implement FAANG</title><p>A high-quality reference genome assembly is a prerequisite to initiate a functional annotation effort. Consequently, we propose to start by selecting taxonomically diverse species with high-quality genome assemblies. These species need to have the support of their research community and a critical mass of investigators, as demonstrated by expression of interest and willingness to use core assays and a common data-sharing infrastructure. Currently, domesticated animal species that meet this requirement include chicken, pig, cattle and sheep. We note, however, that research on other species (for example, goat, salmon and catfish) is rapidly expanding the range of genomes suited for a FAANG approach (Additional file <xref rid="MOESM1" ref-type="media">1</xref>).</p><p>The first phase of the FAANG project will focus on sampling biological replicates representing a limited number of specific biological states to maximize comparisons across species. Where possible, animals with minimal genetic diversity within a species will be sampled. For example, highly inbred lines of chicken can be used. While each species’ community will decide on a particular breed, genetic line or cross, FAANG members are committed to collecting, storing and sharing tissues for initial data collection as well as holding them in reserve for future additional assays. Similarly to recent phases of ENCODE and modENCODE [<xref ref-type="bibr" rid="CR29">29</xref>,<xref ref-type="bibr" rid="CR39">39</xref>], FAANG will mostly focus on tissue samples. A first core set of tissues directly related to the large number of quantitative phenotypes available in several domesticated species has been defined. This includes skeletal muscle, adipose, liver, and tissues collected from the reproductive, immune and nervous systems. We believe this will allow a more direct connection between genome function and quantitative phenotype than the transformed cell lines used extensively in the first phase of the ENCODE project [<xref ref-type="bibr" rid="CR39">39</xref>]. Both male and female progeny will be sampled at neonatal and mature stages.</p></sec><sec id="Sec11"><title>FAANG data types</title><p>Both ENCODE and the International Human Epigenome Consortium have defined robust experimental protocols [<xref ref-type="bibr" rid="CR40">40</xref>]. We will use these standards as a baseline, adapting them where necessary to reflect the complexities of animal breeds and the different tissues available for animal-based experiments. We plan to employ a few specific core assays, which for the most part employ technologies that work across all targeted species (RNA sequencing, chromatin accessibility, and histone marks) as well as have selected laboratories run these assays for the community with standard protocols (Box 1). Additional assays may be performed by individual research groups based upon specific needs and research interests.</p></sec><sec id="Sec12"><title>Common data infrastructure</title><p>Effective coordination, data management and robust quality control (QC) are essential to converting data generated across multiple laboratories into knowledge. The FAANG consortium will promote standardization of experimental protocols and procedures in computational analysis. A sampling coordination task force will promote standards for sampling and storing conditions, including the documentation of animal origin and environmental conditions. A FAANG Data Coordination Centre (DCC) and a Data Analysis Centre (DAC) will be established to ensure high-quality and standardized data generation and analysis, and accessibility of the data to the wider community [<xref ref-type="bibr" rid="CR41">41</xref>]. The FAANG DCC will work with the Sequence, Variation and Sample archives at European Molecular Biology Laboratory European Bioinformatics Institute and the National Center for Biotechnology Information to ensure the data are deposited, with suitable metadata descriptions, in the appropriate archives. In addition, the FAANG DCC will provide quality-controlled data to resources like Ensembl, so that the improved annotation is available to the broadest audience possible. Appropriate metadata and data quality standards for test samples will be defined, and the DCC will help to collect and QC data generated by FAANG partners. The DCC will help groups to appropriately archive sample data and metadata and provide mechanisms to share and access data [<xref ref-type="bibr" rid="CR37">37</xref>]. Key tasks such as mapping the primary sequence data to the appropriate reference genome will be performed by the DCC. The FAANG DAC will consist of distributed groups to establish the best bioinformatic pipelines to analyze FAANG consortium data, and will work closely with the DCC to ensure appropriate QC standards are defined.</p></sec><sec id="Sec13"><title>Future expansion of covered species and diversity within and between species</title><p>As reference genomes for new species are added across the tree of life, new insights can be obtained through functional analysis of such species. Thus, it will be important to continue to expand the evolutionary diversity of FAANG over time.</p><p>It is expected that additional insights will be gained by expanding the genetic diversity within a given species. This fine-scale detail will provide invaluable insight into genetic regulation of phenotypic diversity at a mechanistic level. Furthermore, additional samples and species relevant to specific groups will be collected. New samples may include rumen tissues from ruminant species, mammary tissue from mammals and fiber-producing tissue in animals raised for fiber production. Many aquatic species are able to produce interesting atypical progeny (double haploid and sex-reversed progeny) and both poultry and aquatic species produce very large full-sibling cohorts.</p></sec></sec><sec id="Sec14"><title>Impact of FAANG</title><p>Similar to the ENCODE projects, the FAANG functional maps will generate a comprehensive data resource to be used by multiple groups, over a long time, for multiple purposes [<xref ref-type="bibr" rid="CR42">42</xref>]. Thanks to this organized effort in coordination and standardization, individual research groups will be able to effectively use - and refer to - FAANG datasets, as well as contribute their own datasets from specific genome-to-phenome investigations in different species.</p><p>Overall, we predict completing the aims of the FAANG project will enable the application of molecular phenotypes to the prediction of complex phenotypes and further our understanding of additive and non-additive genetic mechanisms such as dominance and epistasis. Such knowledge can be applied to animal production, human and animal health, evolution, adaptation, and understanding the role of animals in their ecosystem. There is also evidence that early developmental influences can affect transiently inherited acquired traits, indicating that epigenetic modifications to the genome may be another important factor in understanding the inheritance of complex traits. FAANG will provide critical basic information, which will be used to improve food production and inform studies of agriculture, biomedical science, evolution and the environment.</p></sec><sec id="Sec15" sec-type="box"><title>Box 1</title><p><bold>Core assays:</bold></p><p><bold>Transcribed loci</bold> - Identifying the transcribed elements of the genome is a key starting point for functional annotation. RNA-sequencing data generated from libraries prepared using stranded protocols [<xref ref-type="bibr" rid="CR43">43</xref>], the species of interest, and a wide range of tissues, cells and states are critical to describe transcript complexity, including alternative splicing and non-coding RNAs [<xref ref-type="bibr" rid="CR44">44</xref>-<xref ref-type="bibr" rid="CR46">46</xref>].</p><p><bold>Chromatin accessibility and architecture</bold> - Assay for transposase-accessible chromatin sequencing (ATAC-seq), which is based on direct <italic>in vitro</italic> transposition of sequencing adaptors into native chromatin, represents a rapid and sensitive alternative to DNaseI footprinting [<xref ref-type="bibr" rid="CR47">47</xref>] for detecting open chromatin [<xref ref-type="bibr" rid="CR48">48</xref>,<xref ref-type="bibr" rid="CR49">49</xref>]. Chromatin immunoprecipitation sequencing (ChIP-seq) to identify sites bound by the highly conserved insulator-binding protein CCCTC-binding factor can be useful for bridging the gap between gene expression and nuclear organization [<xref ref-type="bibr" rid="CR50">50</xref>].</p><p><bold>Histone modification marks</bold> - The presence of modified histones and the characterization of the sequences to which they are bound will be assayed by well-standardized ChIP-seq assays using validated antibodies that work across a broad range of species. We will start with four histone modification marks among those found most informative by the ENCODE projects [<xref ref-type="bibr" rid="CR1">1</xref>,<xref ref-type="bibr" rid="CR51">51</xref>]:<list list-type="bullet"><list-item><p>Histone H3 lysine 4 trimethylation (H3K4me3), which correlates with promoters of active genes and transcription start sites;</p></list-item><list-item><p>Histone H3 lysine 27 trimethylation (H3K27me3), which marks genes that have been silenced through regional modification;</p></list-item><list-item><p>Histone H3 lysine 27 acetylation (H3K27ac), which marks active regulatory elements, and may distinguish active enhancers and promoters from their inactive counterparts;</p></list-item><list-item><p>H3 lysine 4 monomethylation (H3K4me1), which marks regulatory elements associated with enhancers and other distal elements, but is also enriched downstream of transcription start sites.</p></list-item></list></p><p><bold><italic>Additional assays:</italic></bold></p><p><bold>Methylation</bold> - DNA methylation is a major epigenetic mark and a well-known regulator of gene expression. Genome-wide analysis of 5-methylcytosines can be performed at nucleotide-level resolution by whole-genome or reduced representation bisulfite sequencing [<xref ref-type="bibr" rid="CR52">52</xref>].</p><p><bold>Transcription factor binding sites</bold> - ChIP-seq assays can be used to identify sequences bound by specific proteins [<xref ref-type="bibr" rid="CR40">40</xref>]. However, generating and validating the antibodies necessary will be the main challenge in mapping binding sites for the diversity of transcription factors in species of interest.</p><p><bold>Genome conformation</bold> - Methods of chromosome conformation capture allow the study of the genome-wide chromatin interactome. Hi-C is an upgraded method that provides information about distal elements that, while far apart in the primary sequence, are brought together because of chromosome folding [<xref ref-type="bibr" rid="CR53">53</xref>,<xref ref-type="bibr" rid="CR54">54</xref>]. Hi-C results can be optimally integrated with those from other assays of chromatin accessibility (for example, ATAC-seq).</p></sec></body><back><app-group><app id="App1"><sec id="Sec16"><title>Additional file</title><p><media position="anchor" xlink:href="13059_2015_622_MOESM1_ESM.docx" id="MOESM1"><label>Additional file 1: Table S1.</label><caption><p>Reference species and publications of livestock genomes.</p></caption></media></p></sec></app></app-group><fn-group><fn><p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</p></fn><fn><p><bold>Competing interests</bold></p><p>The authors declare that they have no competing interests.</p></fn><fn><p><bold>Authors’ contributions</bold></p><p>All authors are signatories of the FAANG Consortium; they have contributed to its conception and in drafting of the manuscript. ALA proposed the initial concept and framework for FAANG. ALA, EG, MAG and CKT finalized the manuscript. EG and CKT developed the FAANG web portal and submitted the manuscript. All authors read and approved the final manuscript.</p></fn></fn-group><ack><title>Acknowledgements</title><p>We recognize the role of the EC-US Biotechnology Research Task Force and the Animal Biotechnology Working Group in providing a forum for the initial discussions that led to this paper and the FAANG Consortium.</p></ack><ref-list id="Bib1"><title>References</title><ref id="CR1"><label>1.</label><element-citation publication-type="journal"><person-group person-group-type="author"><collab>Encode Project Consortium</collab></person-group><article-title>An integrated encyclopedia of DNA elements in the human genome</article-title><source>Nature</source><year>2012</year><volume>489</volume><fpage>57</fpage><lpage>74</lpage><pub-id pub-id-type="doi">10.1038/nature11247</pub-id><pub-id pub-id-type="pmid">22955616</pub-id></element-citation></ref><ref id="CR2"><label>2.</label><element-citation publication-type="journal"><person-group 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