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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">New Target Regions for Human Hypertension via Comparative Genomics</title><author><name sortKey="Stoll, Monika" sort="Stoll, Monika" uniqKey="Stoll M" first="Monika" last="Stoll">Monika Stoll</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 USA;</nlm:aff></affiliation></author><author><name sortKey="Kwitek Black, Anne E" sort="Kwitek Black, Anne E" uniqKey="Kwitek Black A" first="Anne E." last="Kwitek-Black">Anne E. Kwitek-Black</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 USA;</nlm:aff></affiliation></author><author><name sortKey="Cowley, Allen W" sort="Cowley, Allen W" uniqKey="Cowley A" first="Allen W." last="Cowley">Allen W. Cowley</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 USA;</nlm:aff></affiliation></author><author><name sortKey="Harris, Eugenie L" sort="Harris, Eugenie L" uniqKey="Harris E" first="Eugenie L." last="Harris">Eugenie L. Harris</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Surgery and Center for Gene Research, University of Otago, Dunedin, New Zealand;</nlm:aff></affiliation></author><author><name sortKey="Harrap, Stephen B" sort="Harrap, Stephen B" uniqKey="Harrap S" first="Stephen B." last="Harrap">Stephen B. Harrap</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Physiology, University of Melbourne, Parkville, Australia;</nlm:aff></affiliation></author><author><name sortKey="Krieger, Jose E" sort="Krieger, Jose E" uniqKey="Krieger J" first="José E." last="Krieger">José E. Krieger</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Laboratory of Molecular Biology and Department of Medicine, University of Sao Paolo School of Medicine, San Paolo, Brazil;</nlm:aff></affiliation></author><author><name sortKey="Printz, Morton P" sort="Printz, Morton P" uniqKey="Printz M" first="Morton P." last="Printz">Morton P. Printz</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Pharmacology, University of California–San Diego, La Jolla, California 92093 USA;</nlm:aff></affiliation></author><author><name sortKey="Provoost, Abraham P" sort="Provoost, Abraham P" uniqKey="Provoost A" first="Abraham P." last="Provoost">Abraham P. Provoost</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Pediatric Surgery, Erasmus University, Rotterdam, Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Sassard, Jean" sort="Sassard, Jean" uniqKey="Sassard J" first="Jean" last="Sassard">Jean Sassard</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Physiology and Clinical Pharmacology, Centre National de la Recherche Scientifique (CNRS) ESA 5014, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Jacob, Howard J" sort="Jacob, Howard J" uniqKey="Jacob H" first="Howard J." last="Jacob">Howard J. Jacob</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 USA;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">10779487</idno><idno type="pmc">310887</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC310887</idno><idno type="RBID">PMC:310887</idno><date when="2000">2000</date><idno type="wicri:Area/Pmc/Corpus">000995</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000995</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">New Target Regions for Human Hypertension via Comparative Genomics</title><author><name sortKey="Stoll, Monika" sort="Stoll, Monika" uniqKey="Stoll M" first="Monika" last="Stoll">Monika Stoll</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 USA;</nlm:aff></affiliation></author><author><name sortKey="Kwitek Black, Anne E" sort="Kwitek Black, Anne E" uniqKey="Kwitek Black A" first="Anne E." last="Kwitek-Black">Anne E. Kwitek-Black</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 USA;</nlm:aff></affiliation></author><author><name sortKey="Cowley, Allen W" sort="Cowley, Allen W" uniqKey="Cowley A" first="Allen W." last="Cowley">Allen W. Cowley</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 USA;</nlm:aff></affiliation></author><author><name sortKey="Harris, Eugenie L" sort="Harris, Eugenie L" uniqKey="Harris E" first="Eugenie L." last="Harris">Eugenie L. Harris</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Surgery and Center for Gene Research, University of Otago, Dunedin, New Zealand;</nlm:aff></affiliation></author><author><name sortKey="Harrap, Stephen B" sort="Harrap, Stephen B" uniqKey="Harrap S" first="Stephen B." last="Harrap">Stephen B. Harrap</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Physiology, University of Melbourne, Parkville, Australia;</nlm:aff></affiliation></author><author><name sortKey="Krieger, Jose E" sort="Krieger, Jose E" uniqKey="Krieger J" first="José E." last="Krieger">José E. Krieger</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Laboratory of Molecular Biology and Department of Medicine, University of Sao Paolo School of Medicine, San Paolo, Brazil;</nlm:aff></affiliation></author><author><name sortKey="Printz, Morton P" sort="Printz, Morton P" uniqKey="Printz M" first="Morton P." last="Printz">Morton P. Printz</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Pharmacology, University of California–San Diego, La Jolla, California 92093 USA;</nlm:aff></affiliation></author><author><name sortKey="Provoost, Abraham P" sort="Provoost, Abraham P" uniqKey="Provoost A" first="Abraham P." last="Provoost">Abraham P. Provoost</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Pediatric Surgery, Erasmus University, Rotterdam, Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Sassard, Jean" sort="Sassard, Jean" uniqKey="Sassard J" first="Jean" last="Sassard">Jean Sassard</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Physiology and Clinical Pharmacology, Centre National de la Recherche Scientifique (CNRS) ESA 5014, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Jacob, Howard J" sort="Jacob, Howard J" uniqKey="Jacob H" first="Howard J." last="Jacob">Howard J. Jacob</name><affiliation><nlm:aff id="N0x969cdd0.0x9c79038">Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 USA;</nlm:aff></affiliation></author></analytic><series><title level="j">Genome Research</title><idno type="ISSN">1088-9051</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Models of human disease have long been used to understand the basic pathophysiology of disease and to facilitate the discovery of new therapeutics. However, as long as models have been used there have been debates about the utility of these models and their ability to mimic clinical disease at the phenotypic level. The application of genetic studies to both humans and model systems allows for a new paradigm, whereby a novel comparative genomics strategy combined with phenotypic correlates can be used to bridge between clinical relevance and model utility. This study presents a comparative genomic map for “candidate hypertension loci in humans” based on translating QTLs between rat and human, predicting 26 chromosomal regions in the human genome that are very likely to harbor hypertension genes. The predictive power appears robust, as several of these regions have also been implicated in mouse, suggesting that these regions represent primary targets for the development of SNPs for linkage disequilibrium testing in humans and/or provide a means to select specific models for additional functional studies and the development of new therapeutics.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Genome Res</journal-id><journal-id journal-id-type="publisher-id">GENOME RES</journal-id><journal-title>Genome Research</journal-title><issn pub-type="ppub">1088-9051</issn><publisher><publisher-name>Cold Spring Harbor Laboratory Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">10779487</article-id><article-id pub-id-type="pmc">310887</article-id><article-categories><subj-group subj-group-type="heading"><subject>Letter</subject></subj-group></article-categories><title-group><article-title>New Target Regions for Human Hypertension via Comparative Genomics</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Stoll</surname><given-names>Monika</given-names></name><xref ref-type="aff" rid="N0x969cdd0.0x9c79038">1</xref></contrib><contrib contrib-type="author"><name><surname>Kwitek-Black</surname><given-names>Anne E.</given-names></name><xref ref-type="aff" rid="N0x969cdd0.0x9c79038">1</xref></contrib><contrib contrib-type="author"><name><surname>Cowley</surname><given-names>Allen W.</given-names><suffix>Jr.</suffix></name><xref ref-type="aff" rid="N0x969cdd0.0x9c79038">1</xref></contrib><contrib contrib-type="author"><name><surname>Harris</surname><given-names>Eugenie L.</given-names></name><xref ref-type="aff" rid="N0x969cdd0.0x9c79038">2</xref></contrib><contrib contrib-type="author"><name><surname>Harrap</surname><given-names>Stephen B.</given-names></name><xref ref-type="aff" rid="N0x969cdd0.0x9c79038">3</xref></contrib><contrib contrib-type="author"><name><surname>Krieger</surname><given-names>José E.</given-names></name><xref ref-type="aff" rid="N0x969cdd0.0x9c79038">4</xref></contrib><contrib contrib-type="author"><name><surname>Printz</surname><given-names>Morton P.</given-names></name><xref ref-type="aff" rid="N0x969cdd0.0x9c79038">5</xref></contrib><contrib contrib-type="author"><name><surname>Provoost</surname><given-names>Abraham P.</given-names></name><xref ref-type="aff" rid="N0x969cdd0.0x9c79038">6</xref></contrib><contrib contrib-type="author"><name><surname>Sassard</surname><given-names>Jean</given-names></name><xref ref-type="aff" rid="N0x969cdd0.0x9c79038">7</xref></contrib><contrib contrib-type="author"><name><surname>Jacob</surname><given-names>Howard J.</given-names></name><xref ref-type="aff" rid="N0x969cdd0.0x9c79038">1</xref><xref ref-type="author-notes" rid="FN8">8</xref></contrib></contrib-group><aff id="N0x969cdd0.0x9c79038"><label>1</label>Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 USA;<label>2</label>Department of Surgery and Center for Gene Research, University of Otago, Dunedin, New Zealand;<label>3</label>Department of Physiology, University of Melbourne, Parkville, Australia;<label>4</label>Laboratory of Molecular Biology and Department of Medicine, University of Sao Paolo School of Medicine, San Paolo, Brazil;<label>5</label>Department of Pharmacology, University of California–San Diego, La Jolla, California 92093 USA;<label>6</label>Department of Pediatric Surgery, Erasmus University, Rotterdam, Netherlands;<label>7</label>Department of Physiology and Clinical Pharmacology, Centre National de la Recherche Scientifique (CNRS) ESA 5014, Lyon, France</aff><author-notes><fn id="FN8"><label>8</label><p>Corresponding author.</p></fn></author-notes><pub-date pub-type="ppub"><month>4</month><year>2000</year></pub-date><volume>10</volume><issue>4</issue><fpage>473</fpage><lpage>482</lpage><history><date date-type="received"><day>13</day><month>7</month><year>1999</year></date><date date-type="accepted"><day>7</day><month>2</month><year>2000</year></date></history><copyright-statement>Copyright © 2000, Cold Spring Harbor Laboratory Press</copyright-statement><copyright-year>2000</copyright-year><abstract><p>Models of human disease have long been used to understand the basic pathophysiology of disease and to facilitate the discovery of new therapeutics. However, as long as models have been used there have been debates about the utility of these models and their ability to mimic clinical disease at the phenotypic level. The application of genetic studies to both humans and model systems allows for a new paradigm, whereby a novel comparative genomics strategy combined with phenotypic correlates can be used to bridge between clinical relevance and model utility. This study presents a comparative genomic map for “candidate hypertension loci in humans” based on translating QTLs between rat and human, predicting 26 chromosomal regions in the human genome that are very likely to harbor hypertension genes. The predictive power appears robust, as several of these regions have also been implicated in mouse, suggesting that these regions represent primary targets for the development of SNPs for linkage disequilibrium testing in humans and/or provide a means to select specific models for additional functional studies and the development of new therapeutics.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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