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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia</title><author><name sortKey="Witt, S H" sort="Witt, S H" uniqKey="Witt S" first="S H" last="Witt">S H Witt</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Streit, F" sort="Streit, F" uniqKey="Streit F" first="F" last="Streit">F. Streit</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Jungkunz, M" sort="Jungkunz, M" uniqKey="Jungkunz M" first="M" last="Jungkunz">M. Jungkunz</name><affiliation><nlm:aff id="aff2"><institution>Central Institute of Mental Health, Clinic of Psychosomatic and Psychotherapeutic Medicine, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Central Institute of Mental Health, Institute for Psychiatric and Psychosomatic Psychotherapy (IPPP)/Psychosomatic Medicine and Psychotherapy, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Frank, J" sort="Frank, J" uniqKey="Frank J" first="J" last="Frank">J. Frank</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Awasthi, S" sort="Awasthi, S" uniqKey="Awasthi S" first="S" last="Awasthi">S. Awasthi</name><affiliation><nlm:aff id="aff4"><institution>Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte</institution>, Berlin,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Reinbold, C S" sort="Reinbold, C S" uniqKey="Reinbold C" first="C S" last="Reinbold">C S Reinbold</name><affiliation><nlm:aff id="aff5"><institution>Human Genomics Research Group, Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Treutlein, J" sort="Treutlein, J" uniqKey="Treutlein J" first="J" last="Treutlein">J. Treutlein</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Degenhardt, F" sort="Degenhardt, F" uniqKey="Degenhardt F" first="F" last="Degenhardt">F. Degenhardt</name><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"><institution>Life and Brain Center, Department of Genomics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Forstner, A J" sort="Forstner, A J" uniqKey="Forstner A" first="A J" last="Forstner">A J Forstner</name><affiliation><nlm:aff id="aff5"><institution>Human Genomics Research Group, Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"><institution>Life and Brain Center, Department of Genomics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff8"><institution>Department of Psychiatry (UPK), University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Heilmann Heimbach, S" sort="Heilmann Heimbach, S" uniqKey="Heilmann Heimbach S" first="S" last="Heilmann-Heimbach">S. Heilmann-Heimbach</name><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dietl, L" sort="Dietl, L" uniqKey="Dietl L" first="L" last="Dietl">L. Dietl</name><affiliation><nlm:aff id="aff9"><institution>Department of Psychiatry, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin</institution>, Berlin,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Schwarze, C E" sort="Schwarze, C E" uniqKey="Schwarze C" first="C E" last="Schwarze">C E Schwarze</name><affiliation><nlm:aff id="aff10"><institution>Department of Clinical Psychology and Psychotherapy, University of Heidelberg</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Schendel, D" sort="Schendel, D" uniqKey="Schendel D" first="D" last="Schendel">D. Schendel</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Strohmaier, J" sort="Strohmaier, J" uniqKey="Strohmaier J" first="J" last="Strohmaier">J. Strohmaier</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Abdellaoui, A" sort="Abdellaoui, A" uniqKey="Abdellaoui A" first="A" last="Abdellaoui">A. Abdellaoui</name><affiliation><nlm:aff id="aff11"><institution>Department of Biological Psychology, Vrije Universiteit Amsterdam</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Adolfsson, R" sort="Adolfsson, R" uniqKey="Adolfsson R" first="R" last="Adolfsson">R. Adolfsson</name><affiliation><nlm:aff id="aff12"><institution>Department of Clinical Sciences, Psychiatry, Umeå University</institution>, Umeå,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Air, T M" sort="Air, T M" uniqKey="Air T" first="T M" last="Air">T M Air</name><affiliation><nlm:aff id="aff13"><institution>Discipline of Psychiatry, University of Adelaide</institution>, Adelaide, SA,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Akil, H" sort="Akil, H" uniqKey="Akil H" first="H" last="Akil">H. Akil</name><affiliation><nlm:aff id="aff14"><institution>Molecular and Behavioral Neuroscience Institute, University of Michigan</institution>, Ann Arbor, MI,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Alda, M" sort="Alda, M" uniqKey="Alda M" first="M" last="Alda">M. Alda</name><affiliation><nlm:aff id="aff15"><institution>Department of Psychiatry, Dalhousie University</institution>, Halifax, NS,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Alliey Rodriguez, N" sort="Alliey Rodriguez, N" uniqKey="Alliey Rodriguez N" first="N" last="Alliey-Rodriguez">N. Alliey-Rodriguez</name><affiliation><nlm:aff id="aff16"><institution>Department of Psychiatry and Behavioral Neuroscience, University of Chicago</institution>, Chicago, IL,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Andreassen, O A" sort="Andreassen, O A" uniqKey="Andreassen O" first="O A" last="Andreassen">O A Andreassen</name><affiliation><nlm:aff id="aff17"><institution>Division Mental Health and Addiction, Oslo University Hospital</institution>, Oslo,<country>Norway</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff18"><institution>NORMENT, University of Oslo</institution>, Oslo,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Babadjanova, G" sort="Babadjanova, G" uniqKey="Babadjanova G" first="G" last="Babadjanova">G. Babadjanova</name><affiliation><nlm:aff id="aff19"><institution>Institute of Pulmonology, Russian State Medical University</institution>, Moscow,<country>Russian Federation</country></nlm:aff></affiliation></author><author><name sortKey="Bass, N J" sort="Bass, N J" uniqKey="Bass N" first="N J" last="Bass">N J Bass</name><affiliation><nlm:aff id="aff20"><institution>Division of Psychiatry, University College London</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Bauer, M" sort="Bauer, M" uniqKey="Bauer M" first="M" last="Bauer">M. Bauer</name><affiliation><nlm:aff id="aff21"><institution>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus</institution>, Dresden,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Baune, B T" sort="Baune, B T" uniqKey="Baune B" first="B T" last="Baune">B T Baune</name><affiliation><nlm:aff id="aff13"><institution>Discipline of Psychiatry, University of Adelaide</institution>, Adelaide, SA,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Bellivier, F" sort="Bellivier, F" uniqKey="Bellivier F" first="F" last="Bellivier">F. Bellivier</name><affiliation><nlm:aff id="aff22"><institution>Inserm, U1144, AP-HP, GH Saint-Louis, Département de Psychiatrie et de Médecine Addictologique</institution>, Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bergen, S" sort="Bergen, S" uniqKey="Bergen S" first="S" last="Bergen">S. Bergen</name><affiliation><nlm:aff id="aff23"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Bethell, A" sort="Bethell, A" uniqKey="Bethell A" first="A" last="Bethell">A. Bethell</name><affiliation><nlm:aff id="aff24"><institution>National Center for Mental Health, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Biernacka, J M" sort="Biernacka, J M" uniqKey="Biernacka J" first="J M" last="Biernacka">J M Biernacka</name><affiliation><nlm:aff id="aff25"><institution>Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Blackwood, D H R" sort="Blackwood, D H R" uniqKey="Blackwood D" first="D H R" last="Blackwood">D H R. Blackwood</name><affiliation><nlm:aff id="aff26"><institution>Division of Psychiatry, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Boks, M P" sort="Boks, M P" uniqKey="Boks M" first="M P" last="Boks">M P Boks</name><affiliation><nlm:aff id="aff27"><institution>Urain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht</institution>, Utrecht,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Boomsma, D I" sort="Boomsma, D I" uniqKey="Boomsma D" first="D I" last="Boomsma">D I Boomsma</name><affiliation><nlm:aff id="aff11"><institution>Department of Biological Psychology, Vrije Universiteit Amsterdam</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="B Rglum, A D" sort="B Rglum, A D" uniqKey="B Rglum A" first="A D" last="B Rglum">A D B Rglum</name><affiliation><nlm:aff id="aff28"><institution>Department of Biomedicine, Aarhus University</institution>, Aarhus,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff29"><institution>iSEQ, Centre for Integrative Sequencing, Aarhus University</institution>, Aarhus,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff30"><institution>iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research</institution>, Aarhus,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Borrmann Hassenbach, M" sort="Borrmann Hassenbach, M" uniqKey="Borrmann Hassenbach M" first="M" last="Borrmann-Hassenbach">M. Borrmann-Hassenbach</name><affiliation><nlm:aff id="aff31"><institution>Medical and Quality Assurance, Clinics of Upper Bavaria</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Brennan, P" sort="Brennan, P" uniqKey="Brennan P" first="P" last="Brennan">P. Brennan</name><affiliation><nlm:aff id="aff32"><institution>Genetic Epidemiology Group, International Agency for Research on Cancer</institution>, Lyon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Budde, M" sort="Budde, M" uniqKey="Budde M" first="M" last="Budde">M. Budde</name><affiliation><nlm:aff id="aff33"><institution>Department of Psychiatry and Psychotherapy, University Medical Center Göttingen</institution>, Goettingen,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff34"><institution>Medical Center of the University of Munich, Campus Innenstadt, Institute of Psychiatric Phenomics and Genomics (IPPG)</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Buttensch N, H N" sort="Buttensch N, H N" uniqKey="Buttensch N H" first="H N" last="Buttensch N">H N Buttensch N</name><affiliation><nlm:aff id="aff35"><institution>Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University</institution>, Aarhus,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Byrne, E M" sort="Byrne, E M" uniqKey="Byrne E" first="E M" last="Byrne">E M Byrne</name><affiliation><nlm:aff id="aff36"><institution>Queensland Brain Institute, The University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Cervantes, P" sort="Cervantes, P" uniqKey="Cervantes P" first="P" last="Cervantes">P. Cervantes</name><affiliation><nlm:aff id="aff37"><institution>Department of Psychiatry, McGill University</institution>, Montreal, QC,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Clarke, T K" sort="Clarke, T K" uniqKey="Clarke T" first="T-K" last="Clarke">T-K Clarke</name><affiliation><nlm:aff id="aff26"><institution>Division of Psychiatry, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Craddock, N" sort="Craddock, N" uniqKey="Craddock N" first="N" last="Craddock">N. Craddock</name><affiliation><nlm:aff id="aff38"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Cruceanu, C" sort="Cruceanu, C" uniqKey="Cruceanu C" first="C" last="Cruceanu">C. Cruceanu</name><affiliation><nlm:aff id="aff39"><institution>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Curtis, D" sort="Curtis, D" uniqKey="Curtis D" first="D" last="Curtis">D. Curtis</name><affiliation><nlm:aff id="aff40"><institution>Centre for Psychiatry, Queen Mary University of London</institution>, London,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff41"><institution>UCL Genetics Institute, University College London</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Czerski, P M" sort="Czerski, P M" uniqKey="Czerski P" first="P M" last="Czerski">P M Czerski</name><affiliation><nlm:aff id="aff42"><institution>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences</institution>, Poznan,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Dannlowski, U" sort="Dannlowski, U" uniqKey="Dannlowski U" first="U" last="Dannlowski">U. Dannlowski</name><affiliation><nlm:aff id="aff43"><institution>Department of Psychiatry, University of Marburg</institution>, Marburg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff44"><institution>Department of Psychiatry, University of Münste</institution>, Münster,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Davis, T" sort="Davis, T" uniqKey="Davis T" first="T" last="Davis">T. Davis</name><affiliation><nlm:aff id="aff13"><institution>Discipline of Psychiatry, University of Adelaide</institution>, Adelaide, SA,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="De Geus, E J C" sort="De Geus, E J C" uniqKey="De Geus E" first="E J C" last="De Geus">E J C. De Geus</name><affiliation><nlm:aff id="aff11"><institution>Department of Biological Psychology, Vrije Universiteit Amsterdam</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Di Florio, A" sort="Di Florio, A" uniqKey="Di Florio A" first="A" last="Di Florio">A. Di Florio</name><affiliation><nlm:aff id="aff45"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Djurovic, S" sort="Djurovic, S" uniqKey="Djurovic S" first="S" last="Djurovic">S. Djurovic</name><affiliation><nlm:aff id="aff46"><institution>Department of Medical Genetics, Oslo University Hospital Ullevål</institution>, Oslo,<country>Norway</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff47"><institution>NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen</institution>, Bergen,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Domenici, E" sort="Domenici, E" uniqKey="Domenici E" first="E" last="Domenici">E. Domenici</name><affiliation><nlm:aff id="aff48"><institution>Centre for Integrative Biology, Università degli Studi di Trento</institution>, Trento,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Edenberg, H J" sort="Edenberg, H J" uniqKey="Edenberg H" first="H J" last="Edenberg">H J Edenberg</name><affiliation><nlm:aff id="aff49"><institution>Indiana University School of Medicine, Department of Biochemistry and Molecular Biology</institution>, Indianapolis, IN,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff50"><institution>Indiana University School of Medicine, Department of Medical and Molecular Genetics</institution>, Indianapolis, IN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Etain, B" sort="Etain, B" uniqKey="Etain B" first="B" last="Etain">B. Etain</name><affiliation><nlm:aff id="aff51"><institution>Faculté de Médecine, Université Paris Est</institution>, Créteil,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Fischer, S B" sort="Fischer, S B" uniqKey="Fischer S" first="S B" last="Fischer">S B Fischer</name><affiliation><nlm:aff id="aff5"><institution>Human Genomics Research Group, Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Forty, L" sort="Forty, L" uniqKey="Forty L" first="L" last="Forty">L. Forty</name><affiliation><nlm:aff id="aff45"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Fraser, C" sort="Fraser, C" uniqKey="Fraser C" first="C" last="Fraser">C. Fraser</name><affiliation><nlm:aff id="aff45"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Frye, M A" sort="Frye, M A" uniqKey="Frye M" first="M A" last="Frye">M A Frye</name><affiliation><nlm:aff id="aff52"><institution>Department of Psychiatry and Psychology, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Fullerton, J M" sort="Fullerton, J M" uniqKey="Fullerton J" first="J M" last="Fullerton">J M Fullerton</name><affiliation><nlm:aff id="aff53"><institution>School of Medical Sciences, University of New South Wales</institution>, Sydney, NSW,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff54"><institution>Neuroscience Research Australia</institution>, Sydney, NSW,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Gade, K" sort="Gade, K" uniqKey="Gade K" first="K" last="Gade">K. Gade</name><affiliation><nlm:aff id="aff33"><institution>Department of Psychiatry and Psychotherapy, University Medical Center Göttingen</institution>, Goettingen,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff34"><institution>Medical Center of the University of Munich, Campus Innenstadt, Institute of Psychiatric Phenomics and Genomics (IPPG)</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Gershon, E S" sort="Gershon, E S" uniqKey="Gershon E" first="E S" last="Gershon">E S Gershon</name><affiliation><nlm:aff id="aff16"><institution>Department of Psychiatry and Behavioral Neuroscience, University of Chicago</institution>, Chicago, IL,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Giegling, I" sort="Giegling, I" uniqKey="Giegling I" first="I" last="Giegling">I. Giegling</name><affiliation><nlm:aff id="aff55"><institution>Department of Psychiatry, University of Halle</institution>, Halle,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Gordon, S D" sort="Gordon, S D" uniqKey="Gordon S" first="S D" last="Gordon">S D Gordon</name><affiliation><nlm:aff id="aff56"><institution>Genetics and Computational Biology, QIMR Berghofer Medical Research Institute</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Gordon Smith, K" sort="Gordon Smith, K" uniqKey="Gordon Smith K" first="K" last="Gordon-Smith">K. Gordon-Smith</name><affiliation><nlm:aff id="aff57"><institution>Department of Psychological Medicine, University of Worcester</institution>, Worcester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Grabe, H J" sort="Grabe, H J" uniqKey="Grabe H" first="H J" last="Grabe">H J Grabe</name><affiliation><nlm:aff id="aff58"><institution>Department of Psychiatry and Psychotherapy, University Medicine Greifswald</institution>, Greifswald,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Green, E K" sort="Green, E K" uniqKey="Green E" first="E K" last="Green">E K Green</name><affiliation><nlm:aff id="aff59"><institution>School of Biomedical and Healthcare Sciences, Plymouth University Peninsula Schools of Medicine and Dentistry</institution>, Plymouth,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Greenwood, T A" sort="Greenwood, T A" uniqKey="Greenwood T" first="T A" last="Greenwood">T A Greenwood</name><affiliation><nlm:aff id="aff60"><institution>Department of Psychiatry, University of California San Diego</institution>, La Jolla, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Grigoroiu Serbanescu, M" sort="Grigoroiu Serbanescu, M" uniqKey="Grigoroiu Serbanescu M" first="M" last="Grigoroiu-Serbanescu">M. Grigoroiu-Serbanescu</name><affiliation><nlm:aff id="aff61"><institution>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital</institution>, Bucharest,<country>Romania</country></nlm:aff></affiliation></author><author><name sortKey="Guzman Parra, J" sort="Guzman Parra, J" uniqKey="Guzman Parra J" first="J" last="Guzman-Parra">J. Guzman-Parra</name><affiliation><nlm:aff id="aff62"><institution>Mental Health Department, Biomedicine Institute, University Regional Hospital</institution>, Málaga,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Hall, L S" sort="Hall, L S" uniqKey="Hall L" first="L S" last="Hall">L S Hall</name><affiliation><nlm:aff id="aff26"><institution>Division of Psychiatry, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff63"><institution>Institute of Genetic Medicine, Newcastle University</institution>, Newcastle upon Tyne,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Hamshere, M" sort="Hamshere, M" uniqKey="Hamshere M" first="M" last="Hamshere">M. Hamshere</name><affiliation><nlm:aff id="aff38"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Hauser, J" sort="Hauser, J" uniqKey="Hauser J" first="J" last="Hauser">J. Hauser</name><affiliation><nlm:aff id="aff42"><institution>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences</institution>, Poznan,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Hautzinger, M" sort="Hautzinger, M" uniqKey="Hautzinger M" first="M" last="Hautzinger">M. Hautzinger</name><affiliation><nlm:aff id="aff64"><institution>Department of Psychology, Eberhard Karls Universität Tübingen</institution>, Tubingen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Heilbronner, U" sort="Heilbronner, U" uniqKey="Heilbronner U" first="U" last="Heilbronner">U. Heilbronner</name><affiliation><nlm:aff id="aff34"><institution>Medical Center of the University of Munich, Campus Innenstadt, Institute of Psychiatric Phenomics and Genomics (IPPG)</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Herms, S" sort="Herms, S" uniqKey="Herms S" first="S" last="Herms">S. Herms</name><affiliation><nlm:aff id="aff5"><institution>Human Genomics Research Group, Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"><institution>Life and Brain Center, Department of Genomics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Hitturlingappa, S" sort="Hitturlingappa, S" uniqKey="Hitturlingappa S" first="S" last="Hitturlingappa">S. Hitturlingappa</name><affiliation><nlm:aff id="aff13"><institution>Discipline of Psychiatry, University of Adelaide</institution>, Adelaide, SA,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Hoffmann, P" sort="Hoffmann, P" uniqKey="Hoffmann P" first="P" last="Hoffmann">P. Hoffmann</name><affiliation><nlm:aff id="aff5"><institution>Human Genomics Research Group, Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"><institution>Life and Brain Center, Department of Genomics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Holmans, P" sort="Holmans, P" uniqKey="Holmans P" first="P" last="Holmans">P. Holmans</name><affiliation><nlm:aff id="aff38"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Hottenga, J J" sort="Hottenga, J J" uniqKey="Hottenga J" first="J-J" last="Hottenga">J-J Hottenga</name><affiliation><nlm:aff id="aff11"><institution>Department of Biological Psychology, Vrije Universiteit Amsterdam</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Jamain, S" sort="Jamain, S" uniqKey="Jamain S" first="S" last="Jamain">S. Jamain</name><affiliation><nlm:aff id="aff51"><institution>Faculté de Médecine, Université Paris Est</institution>, Créteil,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff65"><institution>Inserm U955, Psychiatrie Translationnelle</institution>, Créteil,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Jones, I" sort="Jones, I" uniqKey="Jones I" first="I" last="Jones">I. Jones</name><affiliation><nlm:aff id="aff24"><institution>National Center for Mental Health, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Jones, L A" sort="Jones, L A" uniqKey="Jones L" first="L A" last="Jones">L A Jones</name><affiliation><nlm:aff id="aff57"><institution>Department of Psychological Medicine, University of Worcester</institution>, Worcester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Jureus, A" sort="Jureus, A" uniqKey="Jureus A" first="A" last="Juréus">A. Juréus</name><affiliation><nlm:aff id="aff23"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Kahn, R S" sort="Kahn, R S" uniqKey="Kahn R" first="R S" last="Kahn">R S Kahn</name><affiliation><nlm:aff id="aff66"><institution>University Medical Center Utrecht, Division of Neuroscience, Department of Psychiatry</institution>, Utrecht,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Kammerer Ciernioch, J" sort="Kammerer Ciernioch, J" uniqKey="Kammerer Ciernioch J" first="J" last="Kammerer-Ciernioch">J. Kammerer-Ciernioch</name><affiliation><nlm:aff id="aff67"><institution>Center of Psychiatry Weinsberg</institution>, Weinsberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Kirov, G" sort="Kirov, G" uniqKey="Kirov G" first="G" last="Kirov">G. Kirov</name><affiliation><nlm:aff id="aff38"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kittel Schneider, S" sort="Kittel Schneider, S" uniqKey="Kittel Schneider S" first="S" last="Kittel-Schneider">S. Kittel-Schneider</name><affiliation><nlm:aff id="aff68"><institution>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main</institution>, Frankfurt am Main,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Kloiber, S" sort="Kloiber, S" uniqKey="Kloiber S" first="S" last="Kloiber">S. Kloiber</name><affiliation><nlm:aff id="aff69"><institution>Centre for Addiction and Mental Health</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff70"><institution>Department of Psychiatry, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff71"><institution>Max Planck Institute of Psychiatry</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Knott, S V" sort="Knott, S V" uniqKey="Knott S" first="S V" last="Knott">S V Knott</name><affiliation><nlm:aff id="aff57"><institution>Department of Psychological Medicine, University of Worcester</institution>, Worcester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M" last="Kogevinas">M. Kogevinas</name><affiliation><nlm:aff id="aff72"><institution>Center for Research in Environmental Epidemiology (CREAL)</institution>, Barcelona,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Landen, M" sort="Landen, M" uniqKey="Landen M" first="M" last="Landén">M. Landén</name><affiliation><nlm:aff id="aff23"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff73"><institution>Institute of Neuroscience and Physiology, University of Gothenburg</institution>, Gothenburg,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Leber, M" sort="Leber, M" uniqKey="Leber M" first="M" last="Leber">M. Leber</name><affiliation><nlm:aff id="aff74"><institution>Clinic for Psychiatry and Psychotherapy, University Hospital Cologne</institution>, Cologne,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Leboyer, M" sort="Leboyer, M" uniqKey="Leboyer M" first="M" last="Leboyer">M. Leboyer</name><affiliation><nlm:aff id="aff75"><institution>Inserm U955, Translational Psychiatry Laboratory, AP-HP, DHU PePSY, Department of Psychiatry, Université Paris Est</institution>, Créteil,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Li, Q S" sort="Li, Q S" uniqKey="Li Q" first="Q S" last="Li">Q S Li</name><affiliation><nlm:aff id="aff76"><institution>Janssen Research and Development, LLC, Neuroscience Therapeutic Area</institution>, Titusville, NJ,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lissowska, J" sort="Lissowska, J" uniqKey="Lissowska J" first="J" last="Lissowska">J. Lissowska</name><affiliation><nlm:aff id="aff77"><institution>M. Sklodowska-Curie Cancer Center and Institute of Oncology, Cancer Epidemiology and Prevention</institution>, Warsaw,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Lucae, S" sort="Lucae, S" uniqKey="Lucae S" first="S" last="Lucae">S. Lucae</name><affiliation><nlm:aff id="aff71"><institution>Max Planck Institute of Psychiatry</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Martin, N G" sort="Martin, N G" uniqKey="Martin N" first="N G" last="Martin">N G Martin</name><affiliation><nlm:aff id="aff56"><institution>Genetics and Computational Biology, QIMR Berghofer Medical Research Institute</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff78"><institution>School of Psychology, The University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Mayoral Cleries, F" sort="Mayoral Cleries, F" uniqKey="Mayoral Cleries F" first="F" last="Mayoral-Cleries">F. Mayoral-Cleries</name><affiliation><nlm:aff id="aff62"><institution>Mental Health Department, Biomedicine Institute, University Regional Hospital</institution>, Málaga,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Mcelroy, S L" sort="Mcelroy, S L" uniqKey="Mcelroy S" first="S L" last="Mcelroy">S L Mcelroy</name><affiliation><nlm:aff id="aff79"><institution>Lindner Center of HOPE, Research Institute</institution>, Mason, OH,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Mcintosh, A M" sort="Mcintosh, A M" uniqKey="Mcintosh A" first="A M" last="Mcintosh">A M Mcintosh</name><affiliation><nlm:aff id="aff26"><institution>Division of Psychiatry, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff80"><institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Mckay, J D" sort="Mckay, J D" uniqKey="Mckay J" first="J D" last="Mckay">J D Mckay</name><affiliation><nlm:aff id="aff81"><institution>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer</institution>, Lyon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mcquillin, A" sort="Mcquillin, A" uniqKey="Mcquillin A" first="A" last="Mcquillin">A. Mcquillin</name><affiliation><nlm:aff id="aff82"><institution>Division of Psychiatry, University College London</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Medland, S E" sort="Medland, S E" uniqKey="Medland S" first="S E" last="Medland">S E Medland</name><affiliation><nlm:aff id="aff56"><institution>Genetics and Computational Biology, QIMR Berghofer Medical Research Institute</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Middeldorp, C M" sort="Middeldorp, C M" uniqKey="Middeldorp C" first="C M" last="Middeldorp">C M Middeldorp</name><affiliation><nlm:aff id="aff11"><institution>Department of Biological Psychology, Vrije Universiteit Amsterdam</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Milaneschi, Y" sort="Milaneschi, Y" uniqKey="Milaneschi Y" first="Y" last="Milaneschi">Y. Milaneschi</name><affiliation><nlm:aff id="aff83"><institution>VU University Medical Center and GGZ inGeest, Department of Psychiatry</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Mitchell, P B" sort="Mitchell, P B" uniqKey="Mitchell P" first="P B" last="Mitchell">P B Mitchell</name><affiliation><nlm:aff id="aff84"><institution>School of Psychiatry, University of New South Wales</institution>, Sydney, NSW,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff85"><institution>Black Dog Institute</institution>, Sydney, NSW,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Montgomery, G W" sort="Montgomery, G W" uniqKey="Montgomery G" first="G W" last="Montgomery">G W Montgomery</name><affiliation><nlm:aff id="aff86"><institution>Institute for Molecular Biology, University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Morken, G" sort="Morken, G" uniqKey="Morken G" first="G" last="Morken">G. Morken</name><affiliation><nlm:aff id="aff87"><institution>Department of Neuroscience, Norwegian University of Science and Technology</institution>, Trondheim,<country>Norway</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff88"><institution>Department of Psychiatry, St Olavs University Hospital</institution>, Trondheim,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Mors, O" sort="Mors, O" uniqKey="Mors O" first="O" last="Mors">O. Mors</name><affiliation><nlm:aff id="aff89"><institution>Risskov, Psychosis Research Unit, Aarhus University Hospital</institution>, Aarhus,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff90"><institution>iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Department of Clinical Medicine, Aarhus University</institution>, Aarhus,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Muhleisen, T W" sort="Muhleisen, T W" uniqKey="Muhleisen T" first="T W" last="Mühleisen">T W Mühleisen</name><affiliation><nlm:aff id="aff91"><institution>Research Center Juelich, Institute of Neuroscience and Medicine (INM-1)</institution>, Juelich,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff92"><institution>Division of Medical Genetics, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Muller Myhsok, B" sort="Muller Myhsok, B" uniqKey="Muller Myhsok B" first="B" last="Müller-Myhsok">B. Müller-Myhsok</name><affiliation><nlm:aff id="aff39"><institution>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry</institution>, Munich,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff93"><institution>Munich Cluster for Systems Neurology (SyNergy)</institution>, Munich,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff94"><institution>University of Liverpool</institution>, Liverpool,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Myers, R M" sort="Myers, R M" uniqKey="Myers R" first="R M" last="Myers">R M Myers</name><affiliation><nlm:aff id="aff95"><institution>HudsonAlpha Institute for Biotechnology</institution>, Huntsville, AL,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Nievergelt, C M" sort="Nievergelt, C M" uniqKey="Nievergelt C" first="C M" last="Nievergelt">C M Nievergelt</name><affiliation><nlm:aff id="aff60"><institution>Department of Psychiatry, University of California San Diego</institution>, La Jolla, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Nurnberger, J I" sort="Nurnberger, J I" uniqKey="Nurnberger J" first="J I" last="Nurnberger">J I Nurnberger</name><affiliation><nlm:aff id="aff96"><institution>Department of Psychiatry, Indiana University School of Medicine</institution>, Indianapolis, IN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M C" last="O'Donovan">M C O'Donovan</name><affiliation><nlm:aff id="aff97"><institution>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Loohuis, L M O" sort="Loohuis, L M O" uniqKey="Loohuis L" first="L M O" last="Loohuis">L M O. Loohuis</name><affiliation><nlm:aff id="aff98"><institution>Center for Neurobehavioral Genetics, University of California Los Angeles</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Ophoff, R" sort="Ophoff, R" uniqKey="Ophoff R" first="R" last="Ophoff">R. Ophoff</name><affiliation><nlm:aff id="aff99"><institution>University Medical Center Utrecht, Division of Brain Research</institution>, Utrecht,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Oruc, L" sort="Oruc, L" uniqKey="Oruc L" first="L" last="Oruc">L. Oruc</name><affiliation><nlm:aff id="aff100"><institution>Psychiatry Clinic, Clinical Center University of Sarajevo</institution>, Sarajevo,<country>Bosnia-Herzegovina</country></nlm:aff></affiliation></author><author><name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M J" last="Owen">M J Owen</name><affiliation><nlm:aff id="aff97"><institution>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Paciga, S A" sort="Paciga, S A" uniqKey="Paciga S" first="S A" last="Paciga">S A Paciga</name><affiliation><nlm:aff id="aff101"><institution>Pfizer Global Research and Development, Human Genetics and Computational Biomedicine</institution>, Groton, CT,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Penninx, B W J H" sort="Penninx, B W J H" uniqKey="Penninx B" first="B W J H" last="Penninx">B W J H. Penninx</name><affiliation><nlm:aff id="aff83"><institution>VU University Medical Center and GGZ inGeest, Department of Psychiatry</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Perry, A" sort="Perry, A" uniqKey="Perry A" first="A" last="Perry">A. Perry</name><affiliation><nlm:aff id="aff57"><institution>Department of Psychological Medicine, University of Worcester</institution>, Worcester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Pfennig, A" sort="Pfennig, A" uniqKey="Pfennig A" first="A" last="Pfennig">A. Pfennig</name><affiliation><nlm:aff id="aff21"><institution>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus</institution>, Dresden,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Potash, J B" sort="Potash, J B" uniqKey="Potash J" first="J B" last="Potash">J B Potash</name><affiliation><nlm:aff id="aff102"><institution>Department of Psychiatry, University of Iowa</institution>, Iowa City, IA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Preisig, M" sort="Preisig, M" uniqKey="Preisig M" first="M" last="Preisig">M. Preisig</name><affiliation><nlm:aff id="aff103"><institution>Department of Psychiatry, Psychiatric University Hospital of Lausanne</institution>, Lausanne,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Reif, A" sort="Reif, A" uniqKey="Reif A" first="A" last="Reif">A. Reif</name><affiliation><nlm:aff id="aff68"><institution>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main</institution>, Frankfurt am Main,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Rivas, F" sort="Rivas, F" uniqKey="Rivas F" first="F" last="Rivas">F. Rivas</name><affiliation><nlm:aff id="aff62"><institution>Mental Health Department, Biomedicine Institute, University Regional Hospital</institution>, Málaga,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Rouleau, G A" sort="Rouleau, G A" uniqKey="Rouleau G" first="G A" last="Rouleau">G A Rouleau</name><affiliation><nlm:aff id="aff104"><institution>Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University</institution>, Montreal, QC,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff105"><institution>Montreal Neurological Institute and Hospital</institution>, Montreal, QC,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Schofield, P R" sort="Schofield, P R" uniqKey="Schofield P" first="P R" last="Schofield">P R Schofield</name><affiliation><nlm:aff id="aff53"><institution>School of Medical Sciences, University of New South Wales</institution>, Sydney, NSW,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff54"><institution>Neuroscience Research Australia</institution>, Sydney, NSW,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Schulze, T G" sort="Schulze, T G" uniqKey="Schulze T" first="T G" last="Schulze">T G Schulze</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff33"><institution>Department of Psychiatry and Psychotherapy, University Medical Center Göttingen</institution>, Goettingen,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff34"><institution>Medical Center of the University of Munich, Campus Innenstadt, Institute of Psychiatric Phenomics and Genomics (IPPG)</institution>, Munich,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff106"><institution>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University</institution>, Baltimore, MD,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff107"><institution>NIMH Division of Intramural Research Programs, Human Genetics Branch</institution>, Bethesda, MD,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Schwarz, M" sort="Schwarz, M" uniqKey="Schwarz M" first="M" last="Schwarz">M. Schwarz</name><affiliation><nlm:aff id="aff108"><institution>Psychiatric Center Nordbaden</institution>, Wiesloch,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Scott, L" sort="Scott, L" uniqKey="Scott L" first="L" last="Scott">L. Scott</name><affiliation><nlm:aff id="aff109"><institution>Center for Statistical Genetics, Department of Biostatistics, University of Michigan</institution>, Ann Arbor, MI,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Sinnamon, G C B" sort="Sinnamon, G C B" uniqKey="Sinnamon G" first="G C B" last="Sinnamon">G C B. Sinnamon</name><affiliation><nlm:aff id="aff110"><institution>School of Medicine and Dentistry, James Cook University</institution>, Townsville, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Stahl, E A" sort="Stahl, E A" uniqKey="Stahl E" first="E A" last="Stahl">E A Stahl</name><affiliation><nlm:aff id="aff111"><institution>Broad Institute of MIT and Harvard, Medical and Population Genetics</institution>, Cambridge, MA,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff112"><institution>Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai</institution>, New York, NY,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Strauss, J" sort="Strauss, J" uniqKey="Strauss J" first="J" last="Strauss">J. Strauss</name><affiliation><nlm:aff id="aff69"><institution>Centre for Addiction and Mental Health</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Turecki, G" sort="Turecki, G" uniqKey="Turecki G" first="G" last="Turecki">G. Turecki</name><affiliation><nlm:aff id="aff37"><institution>Department of Psychiatry, McGill University</institution>, Montreal, QC,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Van Der Auwera, S" sort="Van Der Auwera, S" uniqKey="Van Der Auwera S" first="S" last="Van Der Auwera">S. Van Der Auwera</name><affiliation><nlm:aff id="aff58"><institution>Department of Psychiatry and Psychotherapy, University Medicine Greifswald</institution>, Greifswald,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Vedder, H" sort="Vedder, H" uniqKey="Vedder H" first="H" last="Vedder">H. Vedder</name><affiliation><nlm:aff id="aff108"><institution>Psychiatric Center Nordbaden</institution>, Wiesloch,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Vincent, J B" sort="Vincent, J B" uniqKey="Vincent J" first="J B" last="Vincent">J B Vincent</name><affiliation><nlm:aff id="aff113"><institution>Centre for Addiction and Mental Health, Molecular Neuropsychiatry and Development Laboratory</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Willemsen, G" sort="Willemsen, G" uniqKey="Willemsen G" first="G" last="Willemsen">G. Willemsen</name><affiliation><nlm:aff id="aff11"><institution>Department of Biological Psychology, Vrije Universiteit Amsterdam</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Witt, C C" sort="Witt, C C" uniqKey="Witt C" first="C C" last="Witt">C C Witt</name><affiliation><nlm:aff id="aff114"><institution>Department of Anaesthesiology and Operative Intensive Care, University Hospital Mannheim</institution>, Medical Faculty Mannheim/Heidelberg University, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Wray, N R" sort="Wray, N R" uniqKey="Wray N" first="N R" last="Wray">N R Wray</name><affiliation><nlm:aff id="aff36"><institution>Queensland Brain Institute, The University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff115"><institution>Institute for Molecular Bioscience, The University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Xi, H S" sort="Xi, H S" uniqKey="Xi H" first="H S" last="Xi">H S Xi</name><affiliation><nlm:aff id="aff116"><institution>Pfizer Global Research and Development, Computational Sciences Center of Emphasis</institution>, Cambridge, MA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Tadic, A" sort="Tadic, A" uniqKey="Tadic A" first="A" last="Tadic">A. Tadic</name><affiliation><nlm:aff id="aff117"><institution>AGAPLESION Elisabethenstift gGmbh, Department of Psychiatry, Psychosomatics and Psychotherapy</institution>, Darmstadt,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff118"><institution>University Medical Center, Department of Psychiatry and Psychotherapy</institution>, Mainz,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dahmen, N" sort="Dahmen, N" uniqKey="Dahmen N" first="N" last="Dahmen">N. Dahmen</name><affiliation><nlm:aff id="aff118"><institution>University Medical Center, Department of Psychiatry and Psychotherapy</institution>, Mainz,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Schott, B H" sort="Schott, B H" uniqKey="Schott B" first="B H" last="Schott">B H Schott</name><affiliation><nlm:aff id="aff4"><institution>Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte</institution>, Berlin,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff119"><institution>Leibniz Institute for Neurobiology</institution>, Magdeburg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Cichon, S" sort="Cichon, S" uniqKey="Cichon S" first="S" last="Cichon">S. Cichon</name><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff91"><institution>Research Center Juelich, Institute of Neuroscience and Medicine (INM-1)</institution>, Juelich,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff92"><institution>Division of Medical Genetics, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff120"><institution>Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Nothen, M M" sort="Nothen, M M" uniqKey="Nothen M" first="M M" last="Nöthen">M M Nöthen</name><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"><institution>Life and Brain Center, Department of Genomics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ripke, S" sort="Ripke, S" uniqKey="Ripke S" first="S" last="Ripke">S. Ripke</name><affiliation><nlm:aff id="aff4"><institution>Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte</institution>, Berlin,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff121"><institution>Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard</institution>, Cambridge, MA,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff122"><institution>Analytic and Translational Genetics Unit, Department of Medicine, Harvard Medical School, Massachusetts General Hospital</institution>, Boston, MA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Mobascher, A" sort="Mobascher, A" uniqKey="Mobascher A" first="A" last="Mobascher">A. Mobascher</name><affiliation><nlm:aff id="aff118"><institution>University Medical Center, Department of Psychiatry and Psychotherapy</institution>, Mainz,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Rujescu, D" sort="Rujescu, D" uniqKey="Rujescu D" first="D" last="Rujescu">D. Rujescu</name><affiliation><nlm:aff id="aff55"><institution>Department of Psychiatry, University of Halle</institution>, Halle,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Lieb, K" sort="Lieb, K" uniqKey="Lieb K" first="K" last="Lieb">K. Lieb</name><affiliation><nlm:aff id="aff118"><institution>University Medical Center, Department of Psychiatry and Psychotherapy</institution>, Mainz,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Roepke, S" sort="Roepke, S" uniqKey="Roepke S" first="S" last="Roepke">S. Roepke</name><affiliation><nlm:aff id="aff9"><institution>Department of Psychiatry, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin</institution>, Berlin,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Schmahl, C" sort="Schmahl, C" uniqKey="Schmahl C" first="C" last="Schmahl">C. Schmahl</name><affiliation><nlm:aff id="aff2"><institution>Central Institute of Mental Health, Clinic of Psychosomatic and Psychotherapeutic Medicine, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Bohus, M" sort="Bohus, M" uniqKey="Bohus M" first="M" last="Bohus">M. Bohus</name><affiliation><nlm:aff id="aff3"><institution>Central Institute of Mental Health, Institute for Psychiatric and Psychosomatic Psychotherapy (IPPP)/Psychosomatic Medicine and Psychotherapy, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Rietschel, M" sort="Rietschel, M" uniqKey="Rietschel M" first="M" last="Rietschel">M. Rietschel</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28632202</idno><idno type="pmc">5537640</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537640</idno><idno type="RBID">PMC:5537640</idno><idno type="doi">10.1038/tp.2017.115</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000883</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000883</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia</title><author><name sortKey="Witt, S H" sort="Witt, S H" uniqKey="Witt S" first="S H" last="Witt">S H Witt</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Streit, F" sort="Streit, F" uniqKey="Streit F" first="F" last="Streit">F. Streit</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Jungkunz, M" sort="Jungkunz, M" uniqKey="Jungkunz M" first="M" last="Jungkunz">M. Jungkunz</name><affiliation><nlm:aff id="aff2"><institution>Central Institute of Mental Health, Clinic of Psychosomatic and Psychotherapeutic Medicine, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Central Institute of Mental Health, Institute for Psychiatric and Psychosomatic Psychotherapy (IPPP)/Psychosomatic Medicine and Psychotherapy, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Frank, J" sort="Frank, J" uniqKey="Frank J" first="J" last="Frank">J. Frank</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Awasthi, S" sort="Awasthi, S" uniqKey="Awasthi S" first="S" last="Awasthi">S. Awasthi</name><affiliation><nlm:aff id="aff4"><institution>Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte</institution>, Berlin,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Reinbold, C S" sort="Reinbold, C S" uniqKey="Reinbold C" first="C S" last="Reinbold">C S Reinbold</name><affiliation><nlm:aff id="aff5"><institution>Human Genomics Research Group, Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Treutlein, J" sort="Treutlein, J" uniqKey="Treutlein J" first="J" last="Treutlein">J. Treutlein</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Degenhardt, F" sort="Degenhardt, F" uniqKey="Degenhardt F" first="F" last="Degenhardt">F. Degenhardt</name><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"><institution>Life and Brain Center, Department of Genomics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Forstner, A J" sort="Forstner, A J" uniqKey="Forstner A" first="A J" last="Forstner">A J Forstner</name><affiliation><nlm:aff id="aff5"><institution>Human Genomics Research Group, Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"><institution>Life and Brain Center, Department of Genomics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff8"><institution>Department of Psychiatry (UPK), University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Heilmann Heimbach, S" sort="Heilmann Heimbach, S" uniqKey="Heilmann Heimbach S" first="S" last="Heilmann-Heimbach">S. Heilmann-Heimbach</name><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dietl, L" sort="Dietl, L" uniqKey="Dietl L" first="L" last="Dietl">L. Dietl</name><affiliation><nlm:aff id="aff9"><institution>Department of Psychiatry, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin</institution>, Berlin,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Schwarze, C E" sort="Schwarze, C E" uniqKey="Schwarze C" first="C E" last="Schwarze">C E Schwarze</name><affiliation><nlm:aff id="aff10"><institution>Department of Clinical Psychology and Psychotherapy, University of Heidelberg</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Schendel, D" sort="Schendel, D" uniqKey="Schendel D" first="D" last="Schendel">D. Schendel</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Strohmaier, J" sort="Strohmaier, J" uniqKey="Strohmaier J" first="J" last="Strohmaier">J. Strohmaier</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Abdellaoui, A" sort="Abdellaoui, A" uniqKey="Abdellaoui A" first="A" last="Abdellaoui">A. Abdellaoui</name><affiliation><nlm:aff id="aff11"><institution>Department of Biological Psychology, Vrije Universiteit Amsterdam</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Adolfsson, R" sort="Adolfsson, R" uniqKey="Adolfsson R" first="R" last="Adolfsson">R. Adolfsson</name><affiliation><nlm:aff id="aff12"><institution>Department of Clinical Sciences, Psychiatry, Umeå University</institution>, Umeå,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Air, T M" sort="Air, T M" uniqKey="Air T" first="T M" last="Air">T M Air</name><affiliation><nlm:aff id="aff13"><institution>Discipline of Psychiatry, University of Adelaide</institution>, Adelaide, SA,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Akil, H" sort="Akil, H" uniqKey="Akil H" first="H" last="Akil">H. Akil</name><affiliation><nlm:aff id="aff14"><institution>Molecular and Behavioral Neuroscience Institute, University of Michigan</institution>, Ann Arbor, MI,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Alda, M" sort="Alda, M" uniqKey="Alda M" first="M" last="Alda">M. Alda</name><affiliation><nlm:aff id="aff15"><institution>Department of Psychiatry, Dalhousie University</institution>, Halifax, NS,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Alliey Rodriguez, N" sort="Alliey Rodriguez, N" uniqKey="Alliey Rodriguez N" first="N" last="Alliey-Rodriguez">N. Alliey-Rodriguez</name><affiliation><nlm:aff id="aff16"><institution>Department of Psychiatry and Behavioral Neuroscience, University of Chicago</institution>, Chicago, IL,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Andreassen, O A" sort="Andreassen, O A" uniqKey="Andreassen O" first="O A" last="Andreassen">O A Andreassen</name><affiliation><nlm:aff id="aff17"><institution>Division Mental Health and Addiction, Oslo University Hospital</institution>, Oslo,<country>Norway</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff18"><institution>NORMENT, University of Oslo</institution>, Oslo,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Babadjanova, G" sort="Babadjanova, G" uniqKey="Babadjanova G" first="G" last="Babadjanova">G. Babadjanova</name><affiliation><nlm:aff id="aff19"><institution>Institute of Pulmonology, Russian State Medical University</institution>, Moscow,<country>Russian Federation</country></nlm:aff></affiliation></author><author><name sortKey="Bass, N J" sort="Bass, N J" uniqKey="Bass N" first="N J" last="Bass">N J Bass</name><affiliation><nlm:aff id="aff20"><institution>Division of Psychiatry, University College London</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Bauer, M" sort="Bauer, M" uniqKey="Bauer M" first="M" last="Bauer">M. Bauer</name><affiliation><nlm:aff id="aff21"><institution>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus</institution>, Dresden,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Baune, B T" sort="Baune, B T" uniqKey="Baune B" first="B T" last="Baune">B T Baune</name><affiliation><nlm:aff id="aff13"><institution>Discipline of Psychiatry, University of Adelaide</institution>, Adelaide, SA,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Bellivier, F" sort="Bellivier, F" uniqKey="Bellivier F" first="F" last="Bellivier">F. Bellivier</name><affiliation><nlm:aff id="aff22"><institution>Inserm, U1144, AP-HP, GH Saint-Louis, Département de Psychiatrie et de Médecine Addictologique</institution>, Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bergen, S" sort="Bergen, S" uniqKey="Bergen S" first="S" last="Bergen">S. Bergen</name><affiliation><nlm:aff id="aff23"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Bethell, A" sort="Bethell, A" uniqKey="Bethell A" first="A" last="Bethell">A. Bethell</name><affiliation><nlm:aff id="aff24"><institution>National Center for Mental Health, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Biernacka, J M" sort="Biernacka, J M" uniqKey="Biernacka J" first="J M" last="Biernacka">J M Biernacka</name><affiliation><nlm:aff id="aff25"><institution>Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Blackwood, D H R" sort="Blackwood, D H R" uniqKey="Blackwood D" first="D H R" last="Blackwood">D H R. Blackwood</name><affiliation><nlm:aff id="aff26"><institution>Division of Psychiatry, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Boks, M P" sort="Boks, M P" uniqKey="Boks M" first="M P" last="Boks">M P Boks</name><affiliation><nlm:aff id="aff27"><institution>Urain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht</institution>, Utrecht,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Boomsma, D I" sort="Boomsma, D I" uniqKey="Boomsma D" first="D I" last="Boomsma">D I Boomsma</name><affiliation><nlm:aff id="aff11"><institution>Department of Biological Psychology, Vrije Universiteit Amsterdam</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="B Rglum, A D" sort="B Rglum, A D" uniqKey="B Rglum A" first="A D" last="B Rglum">A D B Rglum</name><affiliation><nlm:aff id="aff28"><institution>Department of Biomedicine, Aarhus University</institution>, Aarhus,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff29"><institution>iSEQ, Centre for Integrative Sequencing, Aarhus University</institution>, Aarhus,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff30"><institution>iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research</institution>, Aarhus,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Borrmann Hassenbach, M" sort="Borrmann Hassenbach, M" uniqKey="Borrmann Hassenbach M" first="M" last="Borrmann-Hassenbach">M. Borrmann-Hassenbach</name><affiliation><nlm:aff id="aff31"><institution>Medical and Quality Assurance, Clinics of Upper Bavaria</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Brennan, P" sort="Brennan, P" uniqKey="Brennan P" first="P" last="Brennan">P. Brennan</name><affiliation><nlm:aff id="aff32"><institution>Genetic Epidemiology Group, International Agency for Research on Cancer</institution>, Lyon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Budde, M" sort="Budde, M" uniqKey="Budde M" first="M" last="Budde">M. Budde</name><affiliation><nlm:aff id="aff33"><institution>Department of Psychiatry and Psychotherapy, University Medical Center Göttingen</institution>, Goettingen,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff34"><institution>Medical Center of the University of Munich, Campus Innenstadt, Institute of Psychiatric Phenomics and Genomics (IPPG)</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Buttensch N, H N" sort="Buttensch N, H N" uniqKey="Buttensch N H" first="H N" last="Buttensch N">H N Buttensch N</name><affiliation><nlm:aff id="aff35"><institution>Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University</institution>, Aarhus,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Byrne, E M" sort="Byrne, E M" uniqKey="Byrne E" first="E M" last="Byrne">E M Byrne</name><affiliation><nlm:aff id="aff36"><institution>Queensland Brain Institute, The University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Cervantes, P" sort="Cervantes, P" uniqKey="Cervantes P" first="P" last="Cervantes">P. Cervantes</name><affiliation><nlm:aff id="aff37"><institution>Department of Psychiatry, McGill University</institution>, Montreal, QC,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Clarke, T K" sort="Clarke, T K" uniqKey="Clarke T" first="T-K" last="Clarke">T-K Clarke</name><affiliation><nlm:aff id="aff26"><institution>Division of Psychiatry, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Craddock, N" sort="Craddock, N" uniqKey="Craddock N" first="N" last="Craddock">N. Craddock</name><affiliation><nlm:aff id="aff38"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Cruceanu, C" sort="Cruceanu, C" uniqKey="Cruceanu C" first="C" last="Cruceanu">C. Cruceanu</name><affiliation><nlm:aff id="aff39"><institution>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Curtis, D" sort="Curtis, D" uniqKey="Curtis D" first="D" last="Curtis">D. Curtis</name><affiliation><nlm:aff id="aff40"><institution>Centre for Psychiatry, Queen Mary University of London</institution>, London,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff41"><institution>UCL Genetics Institute, University College London</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Czerski, P M" sort="Czerski, P M" uniqKey="Czerski P" first="P M" last="Czerski">P M Czerski</name><affiliation><nlm:aff id="aff42"><institution>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences</institution>, Poznan,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Dannlowski, U" sort="Dannlowski, U" uniqKey="Dannlowski U" first="U" last="Dannlowski">U. Dannlowski</name><affiliation><nlm:aff id="aff43"><institution>Department of Psychiatry, University of Marburg</institution>, Marburg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff44"><institution>Department of Psychiatry, University of Münste</institution>, Münster,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Davis, T" sort="Davis, T" uniqKey="Davis T" first="T" last="Davis">T. Davis</name><affiliation><nlm:aff id="aff13"><institution>Discipline of Psychiatry, University of Adelaide</institution>, Adelaide, SA,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="De Geus, E J C" sort="De Geus, E J C" uniqKey="De Geus E" first="E J C" last="De Geus">E J C. De Geus</name><affiliation><nlm:aff id="aff11"><institution>Department of Biological Psychology, Vrije Universiteit Amsterdam</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Di Florio, A" sort="Di Florio, A" uniqKey="Di Florio A" first="A" last="Di Florio">A. Di Florio</name><affiliation><nlm:aff id="aff45"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Djurovic, S" sort="Djurovic, S" uniqKey="Djurovic S" first="S" last="Djurovic">S. Djurovic</name><affiliation><nlm:aff id="aff46"><institution>Department of Medical Genetics, Oslo University Hospital Ullevål</institution>, Oslo,<country>Norway</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff47"><institution>NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen</institution>, Bergen,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Domenici, E" sort="Domenici, E" uniqKey="Domenici E" first="E" last="Domenici">E. Domenici</name><affiliation><nlm:aff id="aff48"><institution>Centre for Integrative Biology, Università degli Studi di Trento</institution>, Trento,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Edenberg, H J" sort="Edenberg, H J" uniqKey="Edenberg H" first="H J" last="Edenberg">H J Edenberg</name><affiliation><nlm:aff id="aff49"><institution>Indiana University School of Medicine, Department of Biochemistry and Molecular Biology</institution>, Indianapolis, IN,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff50"><institution>Indiana University School of Medicine, Department of Medical and Molecular Genetics</institution>, Indianapolis, IN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Etain, B" sort="Etain, B" uniqKey="Etain B" first="B" last="Etain">B. Etain</name><affiliation><nlm:aff id="aff51"><institution>Faculté de Médecine, Université Paris Est</institution>, Créteil,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Fischer, S B" sort="Fischer, S B" uniqKey="Fischer S" first="S B" last="Fischer">S B Fischer</name><affiliation><nlm:aff id="aff5"><institution>Human Genomics Research Group, Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Forty, L" sort="Forty, L" uniqKey="Forty L" first="L" last="Forty">L. Forty</name><affiliation><nlm:aff id="aff45"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Fraser, C" sort="Fraser, C" uniqKey="Fraser C" first="C" last="Fraser">C. Fraser</name><affiliation><nlm:aff id="aff45"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Frye, M A" sort="Frye, M A" uniqKey="Frye M" first="M A" last="Frye">M A Frye</name><affiliation><nlm:aff id="aff52"><institution>Department of Psychiatry and Psychology, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Fullerton, J M" sort="Fullerton, J M" uniqKey="Fullerton J" first="J M" last="Fullerton">J M Fullerton</name><affiliation><nlm:aff id="aff53"><institution>School of Medical Sciences, University of New South Wales</institution>, Sydney, NSW,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff54"><institution>Neuroscience Research Australia</institution>, Sydney, NSW,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Gade, K" sort="Gade, K" uniqKey="Gade K" first="K" last="Gade">K. Gade</name><affiliation><nlm:aff id="aff33"><institution>Department of Psychiatry and Psychotherapy, University Medical Center Göttingen</institution>, Goettingen,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff34"><institution>Medical Center of the University of Munich, Campus Innenstadt, Institute of Psychiatric Phenomics and Genomics (IPPG)</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Gershon, E S" sort="Gershon, E S" uniqKey="Gershon E" first="E S" last="Gershon">E S Gershon</name><affiliation><nlm:aff id="aff16"><institution>Department of Psychiatry and Behavioral Neuroscience, University of Chicago</institution>, Chicago, IL,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Giegling, I" sort="Giegling, I" uniqKey="Giegling I" first="I" last="Giegling">I. Giegling</name><affiliation><nlm:aff id="aff55"><institution>Department of Psychiatry, University of Halle</institution>, Halle,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Gordon, S D" sort="Gordon, S D" uniqKey="Gordon S" first="S D" last="Gordon">S D Gordon</name><affiliation><nlm:aff id="aff56"><institution>Genetics and Computational Biology, QIMR Berghofer Medical Research Institute</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Gordon Smith, K" sort="Gordon Smith, K" uniqKey="Gordon Smith K" first="K" last="Gordon-Smith">K. Gordon-Smith</name><affiliation><nlm:aff id="aff57"><institution>Department of Psychological Medicine, University of Worcester</institution>, Worcester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Grabe, H J" sort="Grabe, H J" uniqKey="Grabe H" first="H J" last="Grabe">H J Grabe</name><affiliation><nlm:aff id="aff58"><institution>Department of Psychiatry and Psychotherapy, University Medicine Greifswald</institution>, Greifswald,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Green, E K" sort="Green, E K" uniqKey="Green E" first="E K" last="Green">E K Green</name><affiliation><nlm:aff id="aff59"><institution>School of Biomedical and Healthcare Sciences, Plymouth University Peninsula Schools of Medicine and Dentistry</institution>, Plymouth,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Greenwood, T A" sort="Greenwood, T A" uniqKey="Greenwood T" first="T A" last="Greenwood">T A Greenwood</name><affiliation><nlm:aff id="aff60"><institution>Department of Psychiatry, University of California San Diego</institution>, La Jolla, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Grigoroiu Serbanescu, M" sort="Grigoroiu Serbanescu, M" uniqKey="Grigoroiu Serbanescu M" first="M" last="Grigoroiu-Serbanescu">M. Grigoroiu-Serbanescu</name><affiliation><nlm:aff id="aff61"><institution>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital</institution>, Bucharest,<country>Romania</country></nlm:aff></affiliation></author><author><name sortKey="Guzman Parra, J" sort="Guzman Parra, J" uniqKey="Guzman Parra J" first="J" last="Guzman-Parra">J. Guzman-Parra</name><affiliation><nlm:aff id="aff62"><institution>Mental Health Department, Biomedicine Institute, University Regional Hospital</institution>, Málaga,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Hall, L S" sort="Hall, L S" uniqKey="Hall L" first="L S" last="Hall">L S Hall</name><affiliation><nlm:aff id="aff26"><institution>Division of Psychiatry, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff63"><institution>Institute of Genetic Medicine, Newcastle University</institution>, Newcastle upon Tyne,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Hamshere, M" sort="Hamshere, M" uniqKey="Hamshere M" first="M" last="Hamshere">M. Hamshere</name><affiliation><nlm:aff id="aff38"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Hauser, J" sort="Hauser, J" uniqKey="Hauser J" first="J" last="Hauser">J. Hauser</name><affiliation><nlm:aff id="aff42"><institution>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences</institution>, Poznan,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Hautzinger, M" sort="Hautzinger, M" uniqKey="Hautzinger M" first="M" last="Hautzinger">M. Hautzinger</name><affiliation><nlm:aff id="aff64"><institution>Department of Psychology, Eberhard Karls Universität Tübingen</institution>, Tubingen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Heilbronner, U" sort="Heilbronner, U" uniqKey="Heilbronner U" first="U" last="Heilbronner">U. Heilbronner</name><affiliation><nlm:aff id="aff34"><institution>Medical Center of the University of Munich, Campus Innenstadt, Institute of Psychiatric Phenomics and Genomics (IPPG)</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Herms, S" sort="Herms, S" uniqKey="Herms S" first="S" last="Herms">S. Herms</name><affiliation><nlm:aff id="aff5"><institution>Human Genomics Research Group, Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"><institution>Life and Brain Center, Department of Genomics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Hitturlingappa, S" sort="Hitturlingappa, S" uniqKey="Hitturlingappa S" first="S" last="Hitturlingappa">S. Hitturlingappa</name><affiliation><nlm:aff id="aff13"><institution>Discipline of Psychiatry, University of Adelaide</institution>, Adelaide, SA,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Hoffmann, P" sort="Hoffmann, P" uniqKey="Hoffmann P" first="P" last="Hoffmann">P. Hoffmann</name><affiliation><nlm:aff id="aff5"><institution>Human Genomics Research Group, Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"><institution>Life and Brain Center, Department of Genomics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Holmans, P" sort="Holmans, P" uniqKey="Holmans P" first="P" last="Holmans">P. Holmans</name><affiliation><nlm:aff id="aff38"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Hottenga, J J" sort="Hottenga, J J" uniqKey="Hottenga J" first="J-J" last="Hottenga">J-J Hottenga</name><affiliation><nlm:aff id="aff11"><institution>Department of Biological Psychology, Vrije Universiteit Amsterdam</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Jamain, S" sort="Jamain, S" uniqKey="Jamain S" first="S" last="Jamain">S. Jamain</name><affiliation><nlm:aff id="aff51"><institution>Faculté de Médecine, Université Paris Est</institution>, Créteil,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff65"><institution>Inserm U955, Psychiatrie Translationnelle</institution>, Créteil,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Jones, I" sort="Jones, I" uniqKey="Jones I" first="I" last="Jones">I. Jones</name><affiliation><nlm:aff id="aff24"><institution>National Center for Mental Health, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Jones, L A" sort="Jones, L A" uniqKey="Jones L" first="L A" last="Jones">L A Jones</name><affiliation><nlm:aff id="aff57"><institution>Department of Psychological Medicine, University of Worcester</institution>, Worcester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Jureus, A" sort="Jureus, A" uniqKey="Jureus A" first="A" last="Juréus">A. Juréus</name><affiliation><nlm:aff id="aff23"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Kahn, R S" sort="Kahn, R S" uniqKey="Kahn R" first="R S" last="Kahn">R S Kahn</name><affiliation><nlm:aff id="aff66"><institution>University Medical Center Utrecht, Division of Neuroscience, Department of Psychiatry</institution>, Utrecht,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Kammerer Ciernioch, J" sort="Kammerer Ciernioch, J" uniqKey="Kammerer Ciernioch J" first="J" last="Kammerer-Ciernioch">J. Kammerer-Ciernioch</name><affiliation><nlm:aff id="aff67"><institution>Center of Psychiatry Weinsberg</institution>, Weinsberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Kirov, G" sort="Kirov, G" uniqKey="Kirov G" first="G" last="Kirov">G. Kirov</name><affiliation><nlm:aff id="aff38"><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kittel Schneider, S" sort="Kittel Schneider, S" uniqKey="Kittel Schneider S" first="S" last="Kittel-Schneider">S. Kittel-Schneider</name><affiliation><nlm:aff id="aff68"><institution>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main</institution>, Frankfurt am Main,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Kloiber, S" sort="Kloiber, S" uniqKey="Kloiber S" first="S" last="Kloiber">S. Kloiber</name><affiliation><nlm:aff id="aff69"><institution>Centre for Addiction and Mental Health</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff70"><institution>Department of Psychiatry, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff71"><institution>Max Planck Institute of Psychiatry</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Knott, S V" sort="Knott, S V" uniqKey="Knott S" first="S V" last="Knott">S V Knott</name><affiliation><nlm:aff id="aff57"><institution>Department of Psychological Medicine, University of Worcester</institution>, Worcester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M" last="Kogevinas">M. Kogevinas</name><affiliation><nlm:aff id="aff72"><institution>Center for Research in Environmental Epidemiology (CREAL)</institution>, Barcelona,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Landen, M" sort="Landen, M" uniqKey="Landen M" first="M" last="Landén">M. Landén</name><affiliation><nlm:aff id="aff23"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff73"><institution>Institute of Neuroscience and Physiology, University of Gothenburg</institution>, Gothenburg,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Leber, M" sort="Leber, M" uniqKey="Leber M" first="M" last="Leber">M. Leber</name><affiliation><nlm:aff id="aff74"><institution>Clinic for Psychiatry and Psychotherapy, University Hospital Cologne</institution>, Cologne,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Leboyer, M" sort="Leboyer, M" uniqKey="Leboyer M" first="M" last="Leboyer">M. Leboyer</name><affiliation><nlm:aff id="aff75"><institution>Inserm U955, Translational Psychiatry Laboratory, AP-HP, DHU PePSY, Department of Psychiatry, Université Paris Est</institution>, Créteil,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Li, Q S" sort="Li, Q S" uniqKey="Li Q" first="Q S" last="Li">Q S Li</name><affiliation><nlm:aff id="aff76"><institution>Janssen Research and Development, LLC, Neuroscience Therapeutic Area</institution>, Titusville, NJ,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lissowska, J" sort="Lissowska, J" uniqKey="Lissowska J" first="J" last="Lissowska">J. Lissowska</name><affiliation><nlm:aff id="aff77"><institution>M. Sklodowska-Curie Cancer Center and Institute of Oncology, Cancer Epidemiology and Prevention</institution>, Warsaw,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Lucae, S" sort="Lucae, S" uniqKey="Lucae S" first="S" last="Lucae">S. Lucae</name><affiliation><nlm:aff id="aff71"><institution>Max Planck Institute of Psychiatry</institution>, Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Martin, N G" sort="Martin, N G" uniqKey="Martin N" first="N G" last="Martin">N G Martin</name><affiliation><nlm:aff id="aff56"><institution>Genetics and Computational Biology, QIMR Berghofer Medical Research Institute</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff78"><institution>School of Psychology, The University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Mayoral Cleries, F" sort="Mayoral Cleries, F" uniqKey="Mayoral Cleries F" first="F" last="Mayoral-Cleries">F. Mayoral-Cleries</name><affiliation><nlm:aff id="aff62"><institution>Mental Health Department, Biomedicine Institute, University Regional Hospital</institution>, Málaga,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Mcelroy, S L" sort="Mcelroy, S L" uniqKey="Mcelroy S" first="S L" last="Mcelroy">S L Mcelroy</name><affiliation><nlm:aff id="aff79"><institution>Lindner Center of HOPE, Research Institute</institution>, Mason, OH,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Mcintosh, A M" sort="Mcintosh, A M" uniqKey="Mcintosh A" first="A M" last="Mcintosh">A M Mcintosh</name><affiliation><nlm:aff id="aff26"><institution>Division of Psychiatry, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff80"><institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Mckay, J D" sort="Mckay, J D" uniqKey="Mckay J" first="J D" last="Mckay">J D Mckay</name><affiliation><nlm:aff id="aff81"><institution>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer</institution>, Lyon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mcquillin, A" sort="Mcquillin, A" uniqKey="Mcquillin A" first="A" last="Mcquillin">A. Mcquillin</name><affiliation><nlm:aff id="aff82"><institution>Division of Psychiatry, University College London</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Medland, S E" sort="Medland, S E" uniqKey="Medland S" first="S E" last="Medland">S E Medland</name><affiliation><nlm:aff id="aff56"><institution>Genetics and Computational Biology, QIMR Berghofer Medical Research Institute</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Middeldorp, C M" sort="Middeldorp, C M" uniqKey="Middeldorp C" first="C M" last="Middeldorp">C M Middeldorp</name><affiliation><nlm:aff id="aff11"><institution>Department of Biological Psychology, Vrije Universiteit Amsterdam</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Milaneschi, Y" sort="Milaneschi, Y" uniqKey="Milaneschi Y" first="Y" last="Milaneschi">Y. Milaneschi</name><affiliation><nlm:aff id="aff83"><institution>VU University Medical Center and GGZ inGeest, Department of Psychiatry</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Mitchell, P B" sort="Mitchell, P B" uniqKey="Mitchell P" first="P B" last="Mitchell">P B Mitchell</name><affiliation><nlm:aff id="aff84"><institution>School of Psychiatry, University of New South Wales</institution>, Sydney, NSW,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff85"><institution>Black Dog Institute</institution>, Sydney, NSW,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Montgomery, G W" sort="Montgomery, G W" uniqKey="Montgomery G" first="G W" last="Montgomery">G W Montgomery</name><affiliation><nlm:aff id="aff86"><institution>Institute for Molecular Biology, University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Morken, G" sort="Morken, G" uniqKey="Morken G" first="G" last="Morken">G. Morken</name><affiliation><nlm:aff id="aff87"><institution>Department of Neuroscience, Norwegian University of Science and Technology</institution>, Trondheim,<country>Norway</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff88"><institution>Department of Psychiatry, St Olavs University Hospital</institution>, Trondheim,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Mors, O" sort="Mors, O" uniqKey="Mors O" first="O" last="Mors">O. Mors</name><affiliation><nlm:aff id="aff89"><institution>Risskov, Psychosis Research Unit, Aarhus University Hospital</institution>, Aarhus,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff90"><institution>iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Department of Clinical Medicine, Aarhus University</institution>, Aarhus,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Muhleisen, T W" sort="Muhleisen, T W" uniqKey="Muhleisen T" first="T W" last="Mühleisen">T W Mühleisen</name><affiliation><nlm:aff id="aff91"><institution>Research Center Juelich, Institute of Neuroscience and Medicine (INM-1)</institution>, Juelich,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff92"><institution>Division of Medical Genetics, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Muller Myhsok, B" sort="Muller Myhsok, B" uniqKey="Muller Myhsok B" first="B" last="Müller-Myhsok">B. Müller-Myhsok</name><affiliation><nlm:aff id="aff39"><institution>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry</institution>, Munich,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff93"><institution>Munich Cluster for Systems Neurology (SyNergy)</institution>, Munich,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff94"><institution>University of Liverpool</institution>, Liverpool,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Myers, R M" sort="Myers, R M" uniqKey="Myers R" first="R M" last="Myers">R M Myers</name><affiliation><nlm:aff id="aff95"><institution>HudsonAlpha Institute for Biotechnology</institution>, Huntsville, AL,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Nievergelt, C M" sort="Nievergelt, C M" uniqKey="Nievergelt C" first="C M" last="Nievergelt">C M Nievergelt</name><affiliation><nlm:aff id="aff60"><institution>Department of Psychiatry, University of California San Diego</institution>, La Jolla, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Nurnberger, J I" sort="Nurnberger, J I" uniqKey="Nurnberger J" first="J I" last="Nurnberger">J I Nurnberger</name><affiliation><nlm:aff id="aff96"><institution>Department of Psychiatry, Indiana University School of Medicine</institution>, Indianapolis, IN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M C" last="O'Donovan">M C O'Donovan</name><affiliation><nlm:aff id="aff97"><institution>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Loohuis, L M O" sort="Loohuis, L M O" uniqKey="Loohuis L" first="L M O" last="Loohuis">L M O. Loohuis</name><affiliation><nlm:aff id="aff98"><institution>Center for Neurobehavioral Genetics, University of California Los Angeles</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Ophoff, R" sort="Ophoff, R" uniqKey="Ophoff R" first="R" last="Ophoff">R. Ophoff</name><affiliation><nlm:aff id="aff99"><institution>University Medical Center Utrecht, Division of Brain Research</institution>, Utrecht,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Oruc, L" sort="Oruc, L" uniqKey="Oruc L" first="L" last="Oruc">L. Oruc</name><affiliation><nlm:aff id="aff100"><institution>Psychiatry Clinic, Clinical Center University of Sarajevo</institution>, Sarajevo,<country>Bosnia-Herzegovina</country></nlm:aff></affiliation></author><author><name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M J" last="Owen">M J Owen</name><affiliation><nlm:aff id="aff97"><institution>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University</institution>, Cardiff,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Paciga, S A" sort="Paciga, S A" uniqKey="Paciga S" first="S A" last="Paciga">S A Paciga</name><affiliation><nlm:aff id="aff101"><institution>Pfizer Global Research and Development, Human Genetics and Computational Biomedicine</institution>, Groton, CT,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Penninx, B W J H" sort="Penninx, B W J H" uniqKey="Penninx B" first="B W J H" last="Penninx">B W J H. Penninx</name><affiliation><nlm:aff id="aff83"><institution>VU University Medical Center and GGZ inGeest, Department of Psychiatry</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Perry, A" sort="Perry, A" uniqKey="Perry A" first="A" last="Perry">A. Perry</name><affiliation><nlm:aff id="aff57"><institution>Department of Psychological Medicine, University of Worcester</institution>, Worcester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Pfennig, A" sort="Pfennig, A" uniqKey="Pfennig A" first="A" last="Pfennig">A. Pfennig</name><affiliation><nlm:aff id="aff21"><institution>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus</institution>, Dresden,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Potash, J B" sort="Potash, J B" uniqKey="Potash J" first="J B" last="Potash">J B Potash</name><affiliation><nlm:aff id="aff102"><institution>Department of Psychiatry, University of Iowa</institution>, Iowa City, IA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Preisig, M" sort="Preisig, M" uniqKey="Preisig M" first="M" last="Preisig">M. Preisig</name><affiliation><nlm:aff id="aff103"><institution>Department of Psychiatry, Psychiatric University Hospital of Lausanne</institution>, Lausanne,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Reif, A" sort="Reif, A" uniqKey="Reif A" first="A" last="Reif">A. Reif</name><affiliation><nlm:aff id="aff68"><institution>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main</institution>, Frankfurt am Main,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Rivas, F" sort="Rivas, F" uniqKey="Rivas F" first="F" last="Rivas">F. Rivas</name><affiliation><nlm:aff id="aff62"><institution>Mental Health Department, Biomedicine Institute, University Regional Hospital</institution>, Málaga,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Rouleau, G A" sort="Rouleau, G A" uniqKey="Rouleau G" first="G A" last="Rouleau">G A Rouleau</name><affiliation><nlm:aff id="aff104"><institution>Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University</institution>, Montreal, QC,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff105"><institution>Montreal Neurological Institute and Hospital</institution>, Montreal, QC,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Schofield, P R" sort="Schofield, P R" uniqKey="Schofield P" first="P R" last="Schofield">P R Schofield</name><affiliation><nlm:aff id="aff53"><institution>School of Medical Sciences, University of New South Wales</institution>, Sydney, NSW,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff54"><institution>Neuroscience Research Australia</institution>, Sydney, NSW,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Schulze, T G" sort="Schulze, T G" uniqKey="Schulze T" first="T G" last="Schulze">T G Schulze</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff33"><institution>Department of Psychiatry and Psychotherapy, University Medical Center Göttingen</institution>, Goettingen,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff34"><institution>Medical Center of the University of Munich, Campus Innenstadt, Institute of Psychiatric Phenomics and Genomics (IPPG)</institution>, Munich,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff106"><institution>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University</institution>, Baltimore, MD,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff107"><institution>NIMH Division of Intramural Research Programs, Human Genetics Branch</institution>, Bethesda, MD,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Schwarz, M" sort="Schwarz, M" uniqKey="Schwarz M" first="M" last="Schwarz">M. Schwarz</name><affiliation><nlm:aff id="aff108"><institution>Psychiatric Center Nordbaden</institution>, Wiesloch,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Scott, L" sort="Scott, L" uniqKey="Scott L" first="L" last="Scott">L. Scott</name><affiliation><nlm:aff id="aff109"><institution>Center for Statistical Genetics, Department of Biostatistics, University of Michigan</institution>, Ann Arbor, MI,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Sinnamon, G C B" sort="Sinnamon, G C B" uniqKey="Sinnamon G" first="G C B" last="Sinnamon">G C B. Sinnamon</name><affiliation><nlm:aff id="aff110"><institution>School of Medicine and Dentistry, James Cook University</institution>, Townsville, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Stahl, E A" sort="Stahl, E A" uniqKey="Stahl E" first="E A" last="Stahl">E A Stahl</name><affiliation><nlm:aff id="aff111"><institution>Broad Institute of MIT and Harvard, Medical and Population Genetics</institution>, Cambridge, MA,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff112"><institution>Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai</institution>, New York, NY,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Strauss, J" sort="Strauss, J" uniqKey="Strauss J" first="J" last="Strauss">J. Strauss</name><affiliation><nlm:aff id="aff69"><institution>Centre for Addiction and Mental Health</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Turecki, G" sort="Turecki, G" uniqKey="Turecki G" first="G" last="Turecki">G. Turecki</name><affiliation><nlm:aff id="aff37"><institution>Department of Psychiatry, McGill University</institution>, Montreal, QC,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Van Der Auwera, S" sort="Van Der Auwera, S" uniqKey="Van Der Auwera S" first="S" last="Van Der Auwera">S. Van Der Auwera</name><affiliation><nlm:aff id="aff58"><institution>Department of Psychiatry and Psychotherapy, University Medicine Greifswald</institution>, Greifswald,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Vedder, H" sort="Vedder, H" uniqKey="Vedder H" first="H" last="Vedder">H. Vedder</name><affiliation><nlm:aff id="aff108"><institution>Psychiatric Center Nordbaden</institution>, Wiesloch,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Vincent, J B" sort="Vincent, J B" uniqKey="Vincent J" first="J B" last="Vincent">J B Vincent</name><affiliation><nlm:aff id="aff113"><institution>Centre for Addiction and Mental Health, Molecular Neuropsychiatry and Development Laboratory</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Willemsen, G" sort="Willemsen, G" uniqKey="Willemsen G" first="G" last="Willemsen">G. Willemsen</name><affiliation><nlm:aff id="aff11"><institution>Department of Biological Psychology, Vrije Universiteit Amsterdam</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Witt, C C" sort="Witt, C C" uniqKey="Witt C" first="C C" last="Witt">C C Witt</name><affiliation><nlm:aff id="aff114"><institution>Department of Anaesthesiology and Operative Intensive Care, University Hospital Mannheim</institution>, Medical Faculty Mannheim/Heidelberg University, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Wray, N R" sort="Wray, N R" uniqKey="Wray N" first="N R" last="Wray">N R Wray</name><affiliation><nlm:aff id="aff36"><institution>Queensland Brain Institute, The University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff115"><institution>Institute for Molecular Bioscience, The University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Xi, H S" sort="Xi, H S" uniqKey="Xi H" first="H S" last="Xi">H S Xi</name><affiliation><nlm:aff id="aff116"><institution>Pfizer Global Research and Development, Computational Sciences Center of Emphasis</institution>, Cambridge, MA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Tadic, A" sort="Tadic, A" uniqKey="Tadic A" first="A" last="Tadic">A. Tadic</name><affiliation><nlm:aff id="aff117"><institution>AGAPLESION Elisabethenstift gGmbh, Department of Psychiatry, Psychosomatics and Psychotherapy</institution>, Darmstadt,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff118"><institution>University Medical Center, Department of Psychiatry and Psychotherapy</institution>, Mainz,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dahmen, N" sort="Dahmen, N" uniqKey="Dahmen N" first="N" last="Dahmen">N. Dahmen</name><affiliation><nlm:aff id="aff118"><institution>University Medical Center, Department of Psychiatry and Psychotherapy</institution>, Mainz,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Schott, B H" sort="Schott, B H" uniqKey="Schott B" first="B H" last="Schott">B H Schott</name><affiliation><nlm:aff id="aff4"><institution>Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte</institution>, Berlin,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff119"><institution>Leibniz Institute for Neurobiology</institution>, Magdeburg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Cichon, S" sort="Cichon, S" uniqKey="Cichon S" first="S" last="Cichon">S. Cichon</name><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff91"><institution>Research Center Juelich, Institute of Neuroscience and Medicine (INM-1)</institution>, Juelich,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff92"><institution>Division of Medical Genetics, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff120"><institution>Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Nothen, M M" sort="Nothen, M M" uniqKey="Nothen M" first="M M" last="Nöthen">M M Nöthen</name><affiliation><nlm:aff id="aff6"><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"><institution>Life and Brain Center, Department of Genomics, University of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ripke, S" sort="Ripke, S" uniqKey="Ripke S" first="S" last="Ripke">S. Ripke</name><affiliation><nlm:aff id="aff4"><institution>Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte</institution>, Berlin,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff121"><institution>Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard</institution>, Cambridge, MA,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff122"><institution>Analytic and Translational Genetics Unit, Department of Medicine, Harvard Medical School, Massachusetts General Hospital</institution>, Boston, MA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Mobascher, A" sort="Mobascher, A" uniqKey="Mobascher A" first="A" last="Mobascher">A. Mobascher</name><affiliation><nlm:aff id="aff118"><institution>University Medical Center, Department of Psychiatry and Psychotherapy</institution>, Mainz,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Rujescu, D" sort="Rujescu, D" uniqKey="Rujescu D" first="D" last="Rujescu">D. Rujescu</name><affiliation><nlm:aff id="aff55"><institution>Department of Psychiatry, University of Halle</institution>, Halle,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Lieb, K" sort="Lieb, K" uniqKey="Lieb K" first="K" last="Lieb">K. Lieb</name><affiliation><nlm:aff id="aff118"><institution>University Medical Center, Department of Psychiatry and Psychotherapy</institution>, Mainz,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Roepke, S" sort="Roepke, S" uniqKey="Roepke S" first="S" last="Roepke">S. Roepke</name><affiliation><nlm:aff id="aff9"><institution>Department of Psychiatry, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin</institution>, Berlin,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Schmahl, C" sort="Schmahl, C" uniqKey="Schmahl C" first="C" last="Schmahl">C. Schmahl</name><affiliation><nlm:aff id="aff2"><institution>Central Institute of Mental Health, Clinic of Psychosomatic and Psychotherapeutic Medicine, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Bohus, M" sort="Bohus, M" uniqKey="Bohus M" first="M" last="Bohus">M. Bohus</name><affiliation><nlm:aff id="aff3"><institution>Central Institute of Mental Health, Institute for Psychiatric and Psychosomatic Psychotherapy (IPPP)/Psychosomatic Medicine and Psychotherapy, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Rietschel, M" sort="Rietschel, M" uniqKey="Rietschel M" first="M" last="Rietschel">M. Rietschel</name><affiliation><nlm:aff id="aff1"><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></nlm:aff></affiliation></author></analytic><series><title level="j">Translational Psychiatry</title><idno type="eISSN">2158-3188</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: <italic>DPYD</italic> (<italic>P</italic>=4.42 × 10<sup>−7</sup>) and <italic>PKP4</italic> (<italic>P</italic>=8.67 × 10<sup>−7</sup>); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, <italic>P</italic><sub>FDR</sub>=0.019; FDR, false discovery rate). Prior studies have implicated <italic>DPYD</italic>, <italic>PKP4</italic> and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (<italic>r</italic><sub>g</sub>=0.28 [<italic>P</italic>=2.99 × 10<sup>−3</sup>]), SCZ (<italic>r</italic><sub>g</sub>=0.34 [<italic>P</italic>=4.37 × 10<sup>−5</sup>]) and MDD (<italic>r</italic><sub>g</sub>=0.57 [<italic>P</italic>=1.04 × 10<sup>−3</sup>]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Transl Psychiatry</journal-id><journal-id journal-id-type="iso-abbrev">Transl Psychiatry</journal-id><journal-title-group><journal-title>Translational Psychiatry</journal-title></journal-title-group><issn pub-type="epub">2158-3188</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28632202</article-id><article-id pub-id-type="pmc">5537640</article-id><article-id pub-id-type="pii">tp2017115</article-id><article-id pub-id-type="doi">10.1038/tp.2017.115</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia</article-title><alt-title alt-title-type="running">Genome-wide association 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Mannheim,<country>Germany</country></aff><aff id="aff2"><label>2</label><institution>Central Institute of Mental Health, Clinic of Psychosomatic and Psychotherapeutic Medicine, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></aff><aff id="aff3"><label>3</label><institution>Central Institute of Mental Health, Institute for Psychiatric and Psychosomatic Psychotherapy (IPPP)/Psychosomatic Medicine and Psychotherapy, Medical Faculty Mannheim, Heidelberg University</institution>, Mannheim,<country>Germany</country></aff><aff id="aff4"><label>4</label><institution>Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte</institution>, Berlin,<country>Germany</country></aff><aff id="aff5"><label>5</label><institution>Human Genomics Research Group, Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></aff><aff id="aff6"><label>6</label><institution>Institute of Human Genetics, University of Bonn</institution>, Bonn,<country>Germany</country></aff><aff id="aff7"><label>7</label><institution>Life and Brain Center, Department of Genomics, University of Bonn</institution>, Bonn,<country>Germany</country></aff><aff id="aff8"><label>8</label><institution>Department of Psychiatry (UPK), University of Basel</institution>, Basel,<country>Switzerland</country></aff><aff id="aff9"><label>9</label><institution>Department of Psychiatry, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin</institution>, Berlin,<country>Germany</country></aff><aff id="aff10"><label>10</label><institution>Department of Clinical Psychology and Psychotherapy, University of Heidelberg</institution>, Heidelberg,<country>Germany</country></aff><aff id="aff11"><label>11</label><institution>Department of Biological Psychology, Vrije Universiteit Amsterdam</institution>, Amsterdam,<country>The Netherlands</country></aff><aff id="aff12"><label>12</label><institution>Department of Clinical Sciences, Psychiatry, Umeå University</institution>, Umeå,<country>Sweden</country></aff><aff id="aff13"><label>13</label><institution>Discipline of Psychiatry, University of Adelaide</institution>, Adelaide, SA,<country>Australia</country></aff><aff id="aff14"><label>14</label><institution>Molecular and Behavioral Neuroscience Institute, University of Michigan</institution>, Ann Arbor, MI,<country>USA</country></aff><aff id="aff15"><label>15</label><institution>Department of Psychiatry, Dalhousie University</institution>, Halifax, NS,<country>Canada</country></aff><aff id="aff16"><label>16</label><institution>Department of Psychiatry and Behavioral Neuroscience, University of Chicago</institution>, Chicago, IL,<country>USA</country></aff><aff id="aff17"><label>17</label><institution>Division Mental Health and Addiction, Oslo University Hospital</institution>, Oslo,<country>Norway</country></aff><aff id="aff18"><label>18</label><institution>NORMENT, University of Oslo</institution>, Oslo,<country>Norway</country></aff><aff id="aff19"><label>19</label><institution>Institute of Pulmonology, Russian State Medical University</institution>, Moscow,<country>Russian Federation</country></aff><aff id="aff20"><label>20</label><institution>Division of Psychiatry, University College London</institution>, London,<country>UK</country></aff><aff id="aff21"><label>21</label><institution>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus</institution>, Dresden,<country>Germany</country></aff><aff id="aff22"><label>22</label><institution>Inserm, U1144, AP-HP, GH Saint-Louis, Département de Psychiatrie et de Médecine Addictologique</institution>, Paris,<country>France</country></aff><aff id="aff23"><label>23</label><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></aff><aff id="aff24"><label>24</label><institution>National Center for Mental Health, Cardiff University</institution>, Cardiff,<country>UK</country></aff><aff id="aff25"><label>25</label><institution>Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></aff><aff id="aff26"><label>26</label><institution>Division of Psychiatry, University of Edinburgh</institution>, Edinburgh,<country>UK</country></aff><aff id="aff27"><label>27</label><institution>Urain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht</institution>, Utrecht,<country>The Netherlands</country></aff><aff id="aff28"><label>28</label><institution>Department of Biomedicine, Aarhus University</institution>, Aarhus,<country>Denmark</country></aff><aff id="aff29"><label>29</label><institution>iSEQ, Centre for Integrative Sequencing, Aarhus University</institution>, Aarhus,<country>Denmark</country></aff><aff id="aff30"><label>30</label><institution>iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research</institution>, Aarhus,<country>Denmark</country></aff><aff id="aff31"><label>31</label><institution>Medical and Quality Assurance, Clinics of Upper Bavaria</institution>, Munich,<country>Germany</country></aff><aff id="aff32"><label>32</label><institution>Genetic Epidemiology Group, International Agency for Research on Cancer</institution>, Lyon,<country>France</country></aff><aff id="aff33"><label>33</label><institution>Department of Psychiatry and Psychotherapy, University Medical Center Göttingen</institution>, Goettingen,<country>Germany</country></aff><aff id="aff34"><label>34</label><institution>Medical Center of the University of Munich, Campus Innenstadt, Institute of Psychiatric Phenomics and Genomics (IPPG)</institution>, Munich,<country>Germany</country></aff><aff id="aff35"><label>35</label><institution>Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University</institution>, Aarhus,<country>Denmark</country></aff><aff id="aff36"><label>36</label><institution>Queensland Brain Institute, The University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></aff><aff id="aff37"><label>37</label><institution>Department of Psychiatry, McGill University</institution>, Montreal, QC,<country>Canada</country></aff><aff id="aff38"><label>38</label><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></aff><aff id="aff39"><label>39</label><institution>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry</institution>, Munich,<country>Germany</country></aff><aff id="aff40"><label>40</label><institution>Centre for Psychiatry, Queen Mary University of London</institution>, London,<country>UK</country></aff><aff id="aff41"><label>41</label><institution>UCL Genetics Institute, University College London</institution>, London,<country>UK</country></aff><aff id="aff42"><label>42</label><institution>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences</institution>, Poznan,<country>Poland</country></aff><aff id="aff43"><label>43</label><institution>Department of Psychiatry, University of Marburg</institution>, Marburg,<country>Germany</country></aff><aff id="aff44"><label>44</label><institution>Department of Psychiatry, University of Münste</institution>, Münster,<country>Germany</country></aff><aff id="aff45"><label>45</label><institution>Division of Psychological Medicine and Clinical Neurosciences, Cardiff University</institution>, Cardiff,<country>UK</country></aff><aff id="aff46"><label>46</label><institution>Department of Medical Genetics, Oslo University Hospital Ullevål</institution>, Oslo,<country>Norway</country></aff><aff id="aff47"><label>47</label><institution>NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen</institution>, Bergen,<country>Norway</country></aff><aff id="aff48"><label>48</label><institution>Centre for Integrative Biology, Università degli Studi di Trento</institution>, Trento,<country>Italy</country></aff><aff id="aff49"><label>49</label><institution>Indiana University School of Medicine, Department of Biochemistry and Molecular Biology</institution>, Indianapolis, IN,<country>USA</country></aff><aff id="aff50"><label>50</label><institution>Indiana University School of Medicine, Department of Medical and Molecular Genetics</institution>, Indianapolis, IN,<country>USA</country></aff><aff id="aff51"><label>51</label><institution>Faculté de Médecine, Université Paris Est</institution>, Créteil,<country>France</country></aff><aff id="aff52"><label>52</label><institution>Department of Psychiatry and Psychology, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></aff><aff id="aff53"><label>53</label><institution>School of Medical Sciences, University of New South Wales</institution>, Sydney, NSW,<country>Australia</country></aff><aff id="aff54"><label>54</label><institution>Neuroscience Research Australia</institution>, Sydney, NSW,<country>Australia</country></aff><aff id="aff55"><label>55</label><institution>Department of Psychiatry, University of Halle</institution>, Halle,<country>Germany</country></aff><aff id="aff56"><label>56</label><institution>Genetics and Computational Biology, QIMR Berghofer Medical Research Institute</institution>, Brisbane, QLD,<country>Australia</country></aff><aff id="aff57"><label>57</label><institution>Department of Psychological Medicine, University of Worcester</institution>, Worcester,<country>UK</country></aff><aff id="aff58"><label>58</label><institution>Department of Psychiatry and Psychotherapy, University Medicine Greifswald</institution>, Greifswald,<country>Germany</country></aff><aff id="aff59"><label>59</label><institution>School of Biomedical and Healthcare Sciences, Plymouth University Peninsula Schools of Medicine and Dentistry</institution>, Plymouth,<country>UK</country></aff><aff id="aff60"><label>60</label><institution>Department of Psychiatry, University of California San Diego</institution>, La Jolla, CA,<country>USA</country></aff><aff id="aff61"><label>61</label><institution>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital</institution>, Bucharest,<country>Romania</country></aff><aff id="aff62"><label>62</label><institution>Mental Health Department, Biomedicine Institute, University Regional Hospital</institution>, Málaga,<country>Spain</country></aff><aff id="aff63"><label>63</label><institution>Institute of Genetic Medicine, Newcastle University</institution>, Newcastle upon Tyne,<country>UK</country></aff><aff id="aff64"><label>64</label><institution>Department of Psychology, Eberhard Karls Universität Tübingen</institution>, Tubingen,<country>Germany</country></aff><aff id="aff65"><label>65</label><institution>Inserm U955, Psychiatrie Translationnelle</institution>, Créteil,<country>France</country></aff><aff id="aff66"><label>66</label><institution>University Medical Center Utrecht, Division of Neuroscience, Department of Psychiatry</institution>, Utrecht,<country>The Netherlands</country></aff><aff id="aff67"><label>67</label><institution>Center of Psychiatry Weinsberg</institution>, Weinsberg,<country>Germany</country></aff><aff id="aff68"><label>68</label><institution>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main</institution>, Frankfurt am Main,<country>Germany</country></aff><aff id="aff69"><label>69</label><institution>Centre for Addiction and Mental Health</institution>, Toronto, ON,<country>Canada</country></aff><aff id="aff70"><label>70</label><institution>Department of Psychiatry, University of Toronto</institution>, Toronto, ON,<country>Canada</country></aff><aff id="aff71"><label>71</label><institution>Max Planck Institute of Psychiatry</institution>, Munich,<country>Germany</country></aff><aff id="aff72"><label>72</label><institution>Center for Research in Environmental Epidemiology (CREAL)</institution>, Barcelona,<country>Spain</country></aff><aff id="aff73"><label>73</label><institution>Institute of Neuroscience and Physiology, University of Gothenburg</institution>, Gothenburg,<country>Sweden</country></aff><aff id="aff74"><label>74</label><institution>Clinic for Psychiatry and Psychotherapy, University Hospital Cologne</institution>, Cologne,<country>Germany</country></aff><aff id="aff75"><label>75</label><institution>Inserm U955, Translational Psychiatry Laboratory, AP-HP, DHU PePSY, Department of Psychiatry, Université Paris Est</institution>, Créteil,<country>France</country></aff><aff id="aff76"><label>76</label><institution>Janssen Research and Development, LLC, Neuroscience Therapeutic Area</institution>, Titusville, NJ,<country>USA</country></aff><aff id="aff77"><label>77</label><institution>M. Sklodowska-Curie Cancer Center and Institute of Oncology, Cancer Epidemiology and Prevention</institution>, Warsaw,<country>Poland</country></aff><aff id="aff78"><label>78</label><institution>School of Psychology, The University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></aff><aff id="aff79"><label>79</label><institution>Lindner Center of HOPE, Research Institute</institution>, Mason, OH,<country>USA</country></aff><aff id="aff80"><label>80</label><institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>, Edinburgh,<country>UK</country></aff><aff id="aff81"><label>81</label><institution>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer</institution>, Lyon,<country>France</country></aff><aff id="aff82"><label>82</label><institution>Division of Psychiatry, University College London</institution>, London,<country>UK</country></aff><aff id="aff83"><label>83</label><institution>VU University Medical Center and GGZ inGeest, Department of Psychiatry</institution>, Amsterdam,<country>The Netherlands</country></aff><aff id="aff84"><label>84</label><institution>School of Psychiatry, University of New South Wales</institution>, Sydney, NSW,<country>Australia</country></aff><aff id="aff85"><label>85</label><institution>Black Dog Institute</institution>, Sydney, NSW,<country>Australia</country></aff><aff id="aff86"><label>86</label><institution>Institute for Molecular Biology, University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></aff><aff id="aff87"><label>87</label><institution>Department of Neuroscience, Norwegian University of Science and Technology</institution>, Trondheim,<country>Norway</country></aff><aff id="aff88"><label>88</label><institution>Department of Psychiatry, St Olavs University Hospital</institution>, Trondheim,<country>Norway</country></aff><aff id="aff89"><label>89</label><institution>Risskov, Psychosis Research Unit, Aarhus University Hospital</institution>, Aarhus,<country>Denmark</country></aff><aff id="aff90"><label>90</label><institution>iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Department of Clinical Medicine, Aarhus University</institution>, Aarhus,<country>Denmark</country></aff><aff id="aff91"><label>91</label><institution>Research Center Juelich, Institute of Neuroscience and Medicine (INM-1)</institution>, Juelich,<country>Germany</country></aff><aff id="aff92"><label>92</label><institution>Division of Medical Genetics, University of Basel</institution>, Basel,<country>Switzerland</country></aff><aff id="aff93"><label>93</label><institution>Munich Cluster for Systems Neurology (SyNergy)</institution>, Munich,<country>Germany</country></aff><aff id="aff94"><label>94</label><institution>University of Liverpool</institution>, Liverpool,<country>UK</country></aff><aff id="aff95"><label>95</label><institution>HudsonAlpha Institute for Biotechnology</institution>, Huntsville, AL,<country>USA</country></aff><aff id="aff96"><label>96</label><institution>Department of Psychiatry, Indiana University School of Medicine</institution>, Indianapolis, IN,<country>USA</country></aff><aff id="aff97"><label>97</label><institution>MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University</institution>, Cardiff,<country>UK</country></aff><aff id="aff98"><label>98</label><institution>Center for Neurobehavioral Genetics, University of California Los Angeles</institution>, Los Angeles, CA,<country>USA</country></aff><aff id="aff99"><label>99</label><institution>University Medical Center Utrecht, Division of Brain Research</institution>, Utrecht,<country>The Netherlands</country></aff><aff id="aff100"><label>100</label><institution>Psychiatry Clinic, Clinical Center University of Sarajevo</institution>, Sarajevo,<country>Bosnia-Herzegovina</country></aff><aff id="aff101"><label>101</label><institution>Pfizer Global Research and Development, Human Genetics and Computational Biomedicine</institution>, Groton, CT,<country>USA</country></aff><aff id="aff102"><label>102</label><institution>Department of Psychiatry, University of Iowa</institution>, Iowa City, IA,<country>USA</country></aff><aff id="aff103"><label>103</label><institution>Department of Psychiatry, Psychiatric University Hospital of Lausanne</institution>, Lausanne,<country>Switzerland</country></aff><aff id="aff104"><label>104</label><institution>Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University</institution>, Montreal, QC,<country>Canada</country></aff><aff id="aff105"><label>105</label><institution>Montreal Neurological Institute and Hospital</institution>, Montreal, QC,<country>Canada</country></aff><aff id="aff106"><label>106</label><institution>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University</institution>, Baltimore, MD,<country>USA</country></aff><aff id="aff107"><label>107</label><institution>NIMH Division of Intramural Research Programs, Human Genetics Branch</institution>, Bethesda, MD,<country>USA</country></aff><aff id="aff108"><label>108</label><institution>Psychiatric Center Nordbaden</institution>, Wiesloch,<country>Germany</country></aff><aff id="aff109"><label>109</label><institution>Center for Statistical Genetics, Department of Biostatistics, University of Michigan</institution>, Ann Arbor, MI,<country>USA</country></aff><aff id="aff110"><label>110</label><institution>School of Medicine and Dentistry, James Cook University</institution>, Townsville, QLD,<country>Australia</country></aff><aff id="aff111"><label>111</label><institution>Broad Institute of MIT and Harvard, Medical and Population Genetics</institution>, Cambridge, MA,<country>USA</country></aff><aff id="aff112"><label>112</label><institution>Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai</institution>, New York, NY,<country>USA</country></aff><aff id="aff113"><label>113</label><institution>Centre for Addiction and Mental Health, Molecular Neuropsychiatry and Development Laboratory</institution>, Toronto, ON,<country>Canada</country></aff><aff id="aff114"><label>114</label><institution>Department of Anaesthesiology and Operative Intensive Care, University Hospital Mannheim</institution>, Medical Faculty Mannheim/Heidelberg University, Mannheim,<country>Germany</country></aff><aff id="aff115"><label>115</label><institution>Institute for Molecular Bioscience, The University of Queensland</institution>, Brisbane, QLD,<country>Australia</country></aff><aff id="aff116"><label>116</label><institution>Pfizer Global Research and Development, Computational Sciences Center of Emphasis</institution>, Cambridge, MA,<country>USA</country></aff><aff id="aff117"><label>117</label><institution>AGAPLESION Elisabethenstift gGmbh, Department of Psychiatry, Psychosomatics and Psychotherapy</institution>, Darmstadt,<country>Germany</country></aff><aff id="aff118"><label>118</label><institution>University Medical Center, Department of Psychiatry and Psychotherapy</institution>, Mainz,<country>Germany</country></aff><aff id="aff119"><label>119</label><institution>Leibniz Institute for Neurobiology</institution>, Magdeburg,<country>Germany</country></aff><aff id="aff120"><label>120</label><institution>Department of Biomedicine, University of Basel</institution>, Basel,<country>Switzerland</country></aff><aff id="aff121"><label>121</label><institution>Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard</institution>, Cambridge, MA,<country>USA</country></aff><aff id="aff122"><label>122</label><institution>Analytic and Translational Genetics Unit, Department of Medicine, Harvard Medical School, Massachusetts General Hospital</institution>, Boston, MA,<country>USA</country></aff></contrib-group><author-notes><corresp id="caf1"><label>*</label><institution>Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, University of Heidelberg</institution>, 68159 Mannheim, <country>Germany</country>. E-mail: <email>Stephanie.Witt@zi-mannheim.de</email></corresp><fn id="note1" fn-type="equal"><label>123</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="ppub"><month>06</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>20</day><month>06</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>6</month><year>2017</year></pub-date><volume>7</volume><issue>6</issue><fpage>e1155</fpage><lpage></lpage><history><date date-type="received"><day>16</day><month>02</month><year>2017</year></date><date date-type="accepted"><day>10</day><month>04</month><year>2017</year></date></history><permissions><copyright-statement>Copyright © 2017 The Author(s)</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>The Author(s)</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link></license-p></license></permissions><abstract><p>Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: <italic>DPYD</italic> (<italic>P</italic>=4.42 × 10<sup>−7</sup>) and <italic>PKP4</italic> (<italic>P</italic>=8.67 × 10<sup>−7</sup>); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, <italic>P</italic><sub>FDR</sub>=0.019; FDR, false discovery rate). Prior studies have implicated <italic>DPYD</italic>, <italic>PKP4</italic> and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (<italic>r</italic><sub>g</sub>=0.28 [<italic>P</italic>=2.99 × 10<sup>−3</sup>]), SCZ (<italic>r</italic><sub>g</sub>=0.34 [<italic>P</italic>=4.37 × 10<sup>−5</sup>]) and MDD (<italic>r</italic><sub>g</sub>=0.57 [<italic>P</italic>=1.04 × 10<sup>−3</sup>]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.</p></abstract></article-meta></front><body><sec><title>Introduction</title><p>Borderline personality disorder (BOR; for the sake of readability, we have decided to use the rather unconventional abbreviation ‘BOR’ for Borderline Personality Disorder and the abbreviation ‘BIP’ for Bipolar Disorder) is a complex neuropsychiatric disorder with a lifetime prevalence of around 3%.<sup><xref ref-type="bibr" rid="bib1">1</xref></sup> Untreated cases often have a chronic and severely debilitating clinical course.<sup><xref ref-type="bibr" rid="bib1">1</xref></sup> BOR affects up to 20% of all psychiatric inpatients, and is associated with high health-care utilization. BOR therefore represents a substantial socio-economic burden.<sup><xref ref-type="bibr" rid="bib2">2</xref>, <xref ref-type="bibr" rid="bib3">3</xref></sup></p><p>BOR is characterized by affective instability, emotional dysregulation and poor interpersonal functioning.<sup><xref ref-type="bibr" rid="bib3">3</xref></sup> Suicide rates in BOR range between 6 and 8%, and up to 90% of patients engage in non-suicidal self-injurious behavior.<sup><xref ref-type="bibr" rid="bib4">4</xref></sup> Other prototypical features include high-risk behaviors and impulsive aggression. Current theories view dysfunctions in emotion processing, social interaction and impulsivity as core psychological mechanisms of BOR.<sup><xref ref-type="bibr" rid="bib5">5</xref></sup></p><p>To date, genetic research into BOR has been limited. Available genetic studies have involved small samples and focused on candidate genes, while no genome-wide association study (GWAS) of BOR patients has yet been performed.<sup><xref ref-type="bibr" rid="bib6">6</xref></sup> However, Lubke <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib7">7</xref></sup> conducted a GWAS of borderline personality features using data from three cohorts comprising <italic>n</italic>=5802, <italic>n</italic>=1332 and <italic>n</italic>=1301 participants, respectively. Using the borderline subscale of the Personality Assessment Inventory (PAI-BOR), four borderline personality features (affect instability, identity problems, negative relations and self-harm) were assessed. The most promising signal in the combined analysis of two samples was for seven SNPs in the gene <italic>SERINC5</italic>, which encodes a protein involved in myelination. Two of the SNPs could be replicated in the third sample. Interestingly, here, the effect was highest for the affect instability items, that is, features that are key characteristics of manic phases of bipolar disorder (BIP).</p><p>Understanding of the pathogenesis of BOR remains limited. Both environmental and genetic factors are known to have a role in BOR etiology. Familial aggregation has been demonstrated,<sup><xref ref-type="bibr" rid="bib8">8</xref>, <xref ref-type="bibr" rid="bib9">9</xref></sup> and heritability estimates from twin studies range from 35 to 65%, with higher heritability estimates being obtained with self-ratings.<sup><xref ref-type="bibr" rid="bib10">10</xref>, <xref ref-type="bibr" rid="bib11">11</xref>, <xref ref-type="bibr" rid="bib12">12</xref></sup></p><p>The potential comorbidity between BOR and BIP is part of an ongoing debate. For example, Fornaro <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib13">13</xref></sup> report substantial comorbidity of ~20% with BIP, whereas Tsanas <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib14">14</xref></sup> find clear symptomatic differences between these two diagnostic groups. BOR displays an overlap of some symptoms with BIP, such as affective instability. In contrast, features such as dissociative symptoms, a feeling of chronic emptiness and identity disturbances are specific to BOR.<sup><xref ref-type="bibr" rid="bib15">15</xref></sup> To date, no twin or family study has generated conclusive results concerning a genetic overlap between the two disorders.<sup><xref ref-type="bibr" rid="bib16">16</xref>, <xref ref-type="bibr" rid="bib17">17</xref></sup> However, a twin study<sup><xref ref-type="bibr" rid="bib18">18</xref></sup> and a large-population-based study using polygenic risk score analyses<sup><xref ref-type="bibr" rid="bib19">19</xref></sup> indicate a genetic overlap between borderline personality features and neuroticism, an established risk factor for BIP and other psychiatric disorders.<sup><xref ref-type="bibr" rid="bib20">20</xref></sup></p><p>To the best of our knowledge, the present study represents the first case–control GWAS in BOR, and was performed in one of the largest BOR patient samples worldwide. Given the limited heritability and the expected complex genetic architecture of BOR, the sample is too small to generate significant results for single markers. Instead, the main aim of the investigation was to detect (i) genes and gene sets with a potential involvement in BOR; and (ii) potential genetic overlap with BIP. As a substantial overlap of common risk variants exists between BIP and schizophrenia (SCZ), and to a lesser extent between BIP and major depressive disorder (MDD), and as there is also a high comorbidity of BOR and MDD, a further aim of the study was to determine whether any observed genetic overlap between BOR and BIP, MDD and SCZ was driven by disorder-specific genetic factors using linkage disequilibrium (LD)-score regression and polygenic risk scores (PRS).</p></sec><sec><title>Materials and methods</title><sec><title>Participants</title><p>The present sample comprised 1075 BOR patients and 1675 controls.<sup><xref ref-type="bibr" rid="bib21">21</xref></sup> All the participants provided written informed consent before inclusion. The study was approved by the respective local ethics committees.</p><p>The patients were recruited at the following German academic institutions: Department of Psychosomatic Medicine, Central Institute of Mental Health, Mannheim (<italic>n</italic>=350); Department of Psychiatry and Psychotherapy, University Medical Center Mainz (<italic>n</italic>=231); and the Department of Psychiatry, Charité, Campus Benjamin Franklin, Berlin (<italic>n</italic>=494). Inclusion criteria for patients were: age 16 to 65 years; Central European ancestry; and a lifetime DSM-IV diagnosis of BOR. The control sample comprised 1583 unscreened blood donors from Mannheim, and 92 subjects recruited by the University Medical Center Mainz.</p></sec><sec><title>Clinical assessment</title><p>The diagnoses of BOR were assigned according to DSM-IV criteria and on the basis of structured clinical interviews. The diagnostic criteria for BOR were assessed using the German version of the IPDE<sup><xref ref-type="bibr" rid="bib22">22</xref></sup> or the SKID-II.<sup><xref ref-type="bibr" rid="bib23">23</xref></sup> All the diagnostic interviews were conducted by trained and experienced raters. BOR patients with a comorbid diagnosis of BIP or SCZ assessed with SKID-I<sup><xref ref-type="bibr" rid="bib23">23</xref></sup> were excluded.</p></sec><sec><title>Genotyping</title><p>Automated genomic DNA extraction was performed using the chemagic Magnetic Separation Module I (Chemagen Biopolymer-Technologie, Baesweiler, Germany). Genotyping was performed using the Infinium PsychArray-24 Bead Chip (Illumina, San Diego, CA, USA).</p></sec><sec><title>Quality control and imputation</title><p>A detailed description of the quality control and imputation procedures is provided elsewhere.<sup><xref ref-type="bibr" rid="bib24">24</xref></sup></p><p>Briefly, quality control parameters for the exclusion of subjects and single-nucleotide polymorphisms (SNPs) were: subject missingness >0.02; autosomal heterozygosity deviation (|Fhet|>0.2); SNP missingness >0.02; difference in SNP missingness between cases and controls >0.02; and SNP Hardy–Weinberg equilibrium (<italic>P</italic><10<sup>−6</sup> in controls; <italic>P</italic><10<sup>−10</sup> in cases).</p><p>Genotype imputation was performed using the pre-phasing/imputation stepwise approach in IMPUTE2/SHAPEIT (default parameters and a chunk size of 3 Mb),<sup><xref ref-type="bibr" rid="bib25">25</xref>, <xref ref-type="bibr" rid="bib26">26</xref></sup> using the 1000 Genomes Project reference panel (release ‘v3.macGT1’).<sup><xref ref-type="bibr" rid="bib27">27</xref></sup></p><p>Relatedness testing and population structure analysis were performed using a SNP subset that fulfilled strict quality criteria (INFO >0.8, missingness <1%, minor allele frequency >0.05), and which had been subjected to LD pruning (<italic>r</italic><sup>2</sup>>0.02). This subset comprised 63 854 SNPs. In cryptically related subjects, one member of each pair (ðhat>0.2) was removed at random following the preferential retention of cases over controls. Principal components (PCs) were estimated from genotype data (see <xref ref-type="supplementary-material" rid="sup1">Supplementary Figures 1–6</xref>), and phenotype association was tested using logistic regression. The impact of the PCs on genome-wide test statistics was assessed using <italic>λ</italic>.</p></sec><sec><title>Association analysis</title><p>Including the first four PCs as covariates, an additive logistic regression model was used to test single marker associations, as implemented in PLINK.<sup><xref ref-type="bibr" rid="bib28">28</xref></sup> The <italic>P</italic>-value threshold for genome-wide significance was set at 5 × 10<sup>−8</sup>.</p></sec><sec><title>Gene-based analysis</title><p>To determine whether genes harbored an excess of variants with small <italic>P</italic>-values, a gene-based test was performed with MAGMA Version 1.04 (<ext-link ext-link-type="uri" xlink:href="http://ctg.cncr.nl/software/magma">http://ctg.cncr.nl/software/magma</ext-link>)<sup><xref ref-type="bibr" rid="bib29">29</xref></sup> using genotyped markers only, filtered with a minor allele frequency >1% (<italic>n</italic>=284 220). This test uses summary data and takes LD between variants into account. SNPs within ±10 kb of the gene boundary were assigned to each gene. Obtained <italic>P</italic>-values were Bonferroni-corrected for the number of tested genes (<italic>n</italic>=17 755, <italic>P</italic>=2.8 × 10<sup>−6</sup>).</p></sec><sec><title>Gene-set analysis</title><p>Gene-set-based analysis was implemented using genotyped markers only, filtered as above. As in the gene-based analysis, SNPs within ±10 kb of the gene boundary were assigned to each gene. Gene-set analyses were carried out using Gene Ontology (GO, <ext-link ext-link-type="uri" xlink:href="http://software.broadinstitute.org/gsea/msigdb/">http://software.broadinstitute.org/gsea/msigdb/</ext-link>) terms.</p><p>The discovery gene-set-based analysis was carried out using i-GSEA4GWASv2 (<ext-link ext-link-type="uri" xlink:href="http://gsea4gwas-v2.psych.ac.cn/">http://gsea4gwas-v2.psych.ac.cn/</ext-link>).<sup><xref ref-type="bibr" rid="bib30">30</xref></sup> The size of the gene sets was restricted to 20–200 genes, and the major histocompatibility complex region was excluded. In total, 674 gene sets were tested. The results were adjusted for multiple testing using false discovery rate (FDR). To validate the significant finding, the respective gene set was investigated with (i) GSA-SNP, using the <italic>P</italic>-value of the second-best SNP in each gene (<ext-link ext-link-type="uri" xlink:href="https://gsa.muldas.org">https://gsa.muldas.org</ext-link>)<sup><xref ref-type="bibr" rid="bib31">31</xref></sup> and (ii) MAGMA using summary data and a nominal <italic>P</italic>-value threshold of <italic>P</italic><0.05.</p></sec><sec><title>LD-score regression</title><p>To investigate a possible genetic overlap between BOR and SCZ, BIP and MDD, LD-score regression was performed.<sup><xref ref-type="bibr" rid="bib32">32</xref></sup> Genetic correlations between BOR and (i) BIP, (ii) SCZ and (iii) MDD were calculated<sup><xref ref-type="bibr" rid="bib33">33</xref></sup> using the result files of the Psychiatric Genomics Consortium (PGC) meta-analyses for SCZ (33 640 cases and 43 456 controls),<sup><xref ref-type="bibr" rid="bib34">34</xref></sup> BIP (20 352 cases and 31 358 controls)<sup><xref ref-type="bibr" rid="bib35">35</xref></sup> and MDD (16 823 cases and 25 632 controls).<sup><xref ref-type="bibr" rid="bib35">35</xref></sup> There was no overlap in cases or controls of the present BOR GWAS sample with the PGC samples.</p></sec><sec><title>Polygenic risk score</title><p>To determine the impact of polygenic risk on BOR and subgroups (that is, BOR with and without MDD), PRS were calculated for each subject based on the above-mentioned PGC data sets.</p><p>To obtain a highly informative SNP set with minimal statistical noise, the following were excluded: low frequency SNPs (minor allele frequency <0.1); low-quality variants (imputation INFO <0.9) and indels. Subsequently, these SNPs were clumped discarding markers within 500 kb of, and in high LD (<italic>r</italic><sup>2</sup>⩾0.1) with, another more significant marker. From the major histocompatibility complex region, only one variant with the strongest significance was retained. PRS were calculated as described elsewhere.<sup><xref ref-type="bibr" rid="bib36">36</xref></sup> This involved <italic>P</italic>-value thresholds 5 × 10<sup>−8</sup>, 1 × 10<sup>−6</sup>, 1 × 10<sup>−4</sup>, 0.001, 0.01, 0.05, 0.1, 0.2, 0.5 and 1.0, and multiplication of the natural logarithm of the odds ratio of each variant by the imputation probability for the risk allele. The resulting values were then totaled. For each subject, this resulted in one PRS for SCZ, MDD and BIP for each <italic>P</italic>-value threshold.</p><p>In a first step, the association of the PRS for BIP, SCZ and MDD with BOR case–control status was analyzed using standard logistic regression and by including the four PCs as covariates. For each <italic>P</italic>-value threshold, the proportion of variance explained (Nagelkerke’s <italic>R</italic><sup>2</sup>) in BOR case–control status was computed by comparison of a full model (covariates+PRS) score to a reduced model (covariates only).</p><p>For further exploratory analysis, the <italic>P</italic><0.05 PRS for each disorder was selected (that is, including all markers that reached nominal significance in the training samples). To determine whether the different scores contribute independently to the case–control status, a regression including the PRS for MDD, SCZ and BIP and the four PCs was computed. In a secondary analysis, two further models were computed. These included the PRS for BIP and the PRS of either MDD or SCZ, while controlling for the four PCs.</p><p>Furthermore, PRS were analyzed by differentiating between controls, and patients with or without comorbid MDD. For each PRS, a linear model was computed using the PRS as a dependent variable, disease state as an independent variable and the four PCs as covariates. Differences between groups were assessed using <italic>post hoc</italic> tests (Bonferroni-corrected).</p></sec></sec><sec><title>Results</title><sec><title>Sample characteristics</title><p>Genetic quality control led to the exclusion of 207 subjects. Reasons for exclusion were: (i) insufficient data quality (low call rate), <italic>n</italic>=6; (ii) relatedness, <italic>n</italic>=63; and (iii) population outlier status, <italic>n</italic>=138. After quality control, the sample comprised 998 BOR cases (914 female/84 male) and 1545 controls (868 female/677 male). Mean age for cases was 29.58 years (range: 18–65 years, standard deviation (s.d.=8.64)). Mean age for controls was 44.19 years (range: 18–72 years, s.d.=13.24; details see <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 1</xref>). Of the 998 cases, 666 had comorbid lifetime MDD, and 262 did not (data missing for 40 cases).</p></sec><sec><title>Single marker analysis</title><p>A total of 10 736 316 single markers were included in the analysis. As expected for GWAS on a complex psychiatric disorder with the current sample size, the single marker analysis revealed no significant hit after correction for multiple testing (see <xref ref-type="fig" rid="fig1">Figures 1</xref> and <xref ref-type="fig" rid="fig2">2</xref>). The most significant marker was rs113507694 in <italic>DPPA3</italic> on chromosome 12 (<italic>P</italic>=2.01 × 10<sup>−07</sup>; odds ratio =0.35, minor allele frequency =0.03, INFO =0.59). Single markers with <italic>P</italic><1 × 10<sup>−5</sup> are listed in <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 2</xref>.</p></sec><sec><title>Gene-based analysis</title><p>In the gene-based analysis, a total of 17 755 genes were tested. Two genes showed significant association with BOR after correction for multiple testing: the gene coding for Plakophilin-4 on chromosome 2 (<italic>PKP4</italic>; <italic>P</italic>=8.24 × 10<sup>−7</sup>); and the gene coding for dihydropyrimidine dehydrogenase on chromosome 1 (<italic>DPYD</italic>, <italic>P</italic>=1.20 × 10<sup>−6</sup>). The most significant genes (<italic>P</italic><5 × 10<sup>−4</sup>) are listed in <xref rid="tbl1" ref-type="table">Table 1</xref>. The top hit of the previous GWAS of borderline personality features, <italic>SERINC5,</italic> achieved nominal significance in the present study (<italic>P</italic><sub>uncorrected</sub>=0.016).</p></sec><sec><title>Gene-set analysis</title><p>Gene-set analysis with i-GSEA4GWASv2 revealed one significant gene set: exocytosis (GO: 0006887; <italic>P</italic><sub>FDR</sub>=0.019). Of 25 genes in this gene set, 22 were mapped with variants and 15 showed nominally significant associations. Details on significant and nonsignificant genes in this gene set are provided in <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 3</xref>. All gene sets with <italic>P</italic><sub>uncorrected</sub><0.01 are shown in <xref rid="tbl2" ref-type="table">Table 2</xref>. A technical replication analysis with GSA-SNP and MAGMA confirmed the gene-set exocytosis (GSA-SNP: <italic>P</italic><sub>uncorrected</sub>=2.32 × 10<sup>−4</sup>; MAGMA: <italic>P</italic><sub>uncorrected</sub>=0.056).</p></sec><sec><title>LD-score regression</title><p>Significant genetic correlations with BOR were found for BIP (<italic>r</italic><sub>g</sub>=0.28; s.e.=0.094; <italic>P</italic>=2.99 × 10<sup>−3</sup>), MDD (<italic>r</italic><sub>g</sub>=0.57; s.e.=0.18; <italic>P</italic>=1.04 × 10<sup>−3</sup>) and SCZ (<italic>r</italic><sub>g</sub>=0.34; s.e.=0.082; <italic>P</italic>=4.37 × 10<sup>−5</sup>). A meta-analytic comparison revealed no significant differences between the correlations (all <italic>P</italic>>0.13).</p></sec><sec><title>Polygenic risk score</title><p>PRS analysis revealed significant associations with BOR for the PRS of BIP, MDD and SCZ. SCZ PRS were significant for all investigated thresholds. BIP and MDD scores were significant for all PRS that included SNPs with <italic>P</italic>-values higher than 0.0001 and 0.001, respectively (see <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 4</xref>). The share of variance explained in BOR case–control status (Nagelkerke’s <italic>R</italic><sup>2</sup>) by the respective PRS was up to 0.86% for BIP; up to 3.1% for SCZ; and up to 2.1% for MDD (see <xref ref-type="fig" rid="fig3">Figure 3</xref> and <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 4</xref>).</p><p>Simultaneous addition of the PRS for SCZ, BIP and MDD (threshold <italic>P</italic><0.05) to the regression model explained 4.4% of the variance (Nagelkerke’s <italic>R</italic><sup>2</sup>) in BOR case–control status. The PRS for SCZ and the PRS for MDD were significant predictors (<italic>P</italic>=9.78 × 10<sup>−9</sup> and <italic>P</italic>=1.9 × 10<sup>−7</sup>, respectively). The PRS for BIP was not a significant predictor in this model (<italic>P</italic>=0.28).</p><p>A secondary analysis was then performed including (i) BIP PRS with MDD PRS and (ii) BIP PRS with SCZ PRS. Here, BIP PRS explained variance independently of MDD PRS (<italic>P</italic>=0.0067), but not of SCZ PRS (<italic>P</italic>=0.11).</p><p>Differentiation between cases with and without comorbid MDD and controls revealed significant effects of BOR diagnosis on PRS for BIP, SCZ and MDD (all <italic>P</italic><0.001, see <xref ref-type="fig" rid="fig4">Figure 4</xref>). <italic>Post hoc</italic> analyses revealed no differences in PRS for the BIP, SCZ or MDD PRS of the BOR subgroup with comorbid MDD compared with the BOR subgroup without MDD (all <italic>P</italic>>0.5).</p><p>Compared with controls, PRS for SCZ and MDD were significantly increased in the BOR subgroups with and without comorbid MDD (all <italic>P</italic><0.001). The PRS for BIP only showed a significant difference to controls in the BOR subgroup with comorbid MDD (<italic>P</italic><0.001, see <xref ref-type="fig" rid="fig4">Figure 4</xref>).</p></sec></sec><sec><title>Discussion</title><p>The present study is the first case–control GWAS of BOR. As expected, no genome-wide significant association was found for any single marker. In the gene-based test, however, two genes achieved genome-wide significance: dihydropyrimidine dehydrogenase (<italic>DPYD</italic>) and Plakophilin-4 (<italic>PKP4</italic>). <italic>DPYD</italic> encodes a pyrimidine catabolic enzyme, which is the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Genetic deficiency of this enzyme results in an error in pyrimidine metabolism.<sup><xref ref-type="bibr" rid="bib37">37</xref></sup> This is associated with thymine–uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy (<ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/gene/1806">http://www.ncbi.nlm.nih.gov/gene/1806</ext-link>). Recent PGC meta-analyses revealed an association between <italic>DPYD</italic> and SCZ and BIP.<sup><xref ref-type="bibr" rid="bib34">34</xref>, <xref ref-type="bibr" rid="bib38">38</xref>, <xref ref-type="bibr" rid="bib39">39</xref></sup><italic>DPYD</italic> contains a binding site for the micro-RNA miR-137, which has previously been associated with schizophrenia,<sup><xref ref-type="bibr" rid="bib40">40</xref></sup> and a previous exome-sequencing study reported two putative functional <italic>de novo</italic> variants in <italic>DPYD</italic> in cases with SCZ.<sup><xref ref-type="bibr" rid="bib41">41</xref></sup><italic>PKP4</italic> is involved in the regulation of cell adhesion and cytoskeletal organization.<sup><xref ref-type="bibr" rid="bib42">42</xref></sup> In pathway analyses of PGC GWAS data, cell adhesion was associated with BIP,<sup><xref ref-type="bibr" rid="bib43">43</xref></sup> and SCZ,<sup><xref ref-type="bibr" rid="bib44">44</xref></sup> whereas cell junction was implicated in MDD, as well as in an integrative pathway analysis of all three disorders.<sup><xref ref-type="bibr" rid="bib45">45</xref></sup></p><p><italic>SERINC5,</italic> which was the top hit of the previous GWAS of Borderline personality features,<sup><xref ref-type="bibr" rid="bib7">7</xref></sup> achieved nominal significance in the present study. The protein SERINC5 incorporates serine into newly forming membrane lipids, and is enriched in myelin in the brain.<sup><xref ref-type="bibr" rid="bib46">46</xref></sup> Previous research suggests that decreased myelination is associated with a reduced capacity for social interaction.<sup><xref ref-type="bibr" rid="bib7">7</xref>, <xref ref-type="bibr" rid="bib47">47</xref></sup></p><p>The gene-set analyses yielded significant results for exocytosis. In neuronal synapses, exocytosis is triggered by an influx of calcium and critically underlies synaptic signaling. Dysregulated neuronal signaling and exocytosis are core features of neurodevelopmental psychiatric disorders such as the autism spectrum disorders and intellectual disability.<sup><xref ref-type="bibr" rid="bib48">48</xref>, <xref ref-type="bibr" rid="bib49">49</xref></sup> Moreover, recent findings from large meta-analyses have implicated dysregulated neuronal signaling and exocytosis in the molecular mechanisms of BIP, SCZ and MDD.<sup><xref ref-type="bibr" rid="bib48">48</xref>, <xref ref-type="bibr" rid="bib50">50</xref>, <xref ref-type="bibr" rid="bib51">51</xref></sup> These processes may now represent promising starting points for further research into BOR.</p><p>The most interesting finding of this study is that BOR showed a genetic overlap with BIP, SCZ and MDD. Notably, BIP did not show a higher correlation with BOR (<italic>r</italic><sub>g</sub>=0.28) than SCZ (<italic>r</italic><sub>g</sub>=0.34) or MDD (<italic>r</italic><sub>g</sub>=0.57). In view of the present sample size, these values must be viewed with caution. A more accurate estimation of these correlations will require calculations in larger cohorts.</p><p>Although comorbid BIP was excluded in the present BOR patients, the possibility that the observed genetic overlap between BOR and BIP was at least partly attributable to misdiagnosis cannot be excluded. However, an alternative explanation appears more likely, that is, that disorders currently categorized as BOR and BIP share a common genetic background, and they also do so with SCZ and MDD. This hypothesis is supported by the present observation of a genetic overlap between BOR and SCZ, two disorders that are rarely misdiagnosed by psychiatrists, despite the presence of common psychotic symptoms.</p><p>An explanation could also be that the genetic commonality between BOR and BIP, SCZ, and MDD might be due to a common effect of MDD. Prior to the introduction of DSM-IV, a history of MDD was required for a diagnosis of BIP, and MDD has a high prevalence in patients with SCZ (25-85%).<sup><xref ref-type="bibr" rid="bib52">52</xref>, <xref ref-type="bibr" rid="bib53">53</xref></sup> Therefore, the MDD genetic risk variants that are common to BOR, BIP, and SCZ may be responsible for the observed overlap. For this reason, we conducted two further analyses. First, we compared PRS of BIP, SCZ and MDD in subsamples of BOR patients with (~60%) and without comorbid MDD. Here, no differences in any of the PRS were found. Second, we performed a joint analysis of PRS of BIP, SCZ and MDD in a logistic regression analysis in BOR patients vs controls. Here, no differences were found in any of the PRS. Second, we performed a joint analysis of the PRS of BIP, SCZ and MDD in a logistic regression analysis in BOR patients vs controls. Here, both the SCZ and the MDD risk score explained variance in BOR case–control status independently. Secondary analysis revealed that the BIP risk score explained variance independently of the MDD risk score but not of the SCZ risk score. These results indicate that comorbidity with MDD does not explain the genetic overlap between BOR and BIP, SCZ and MDD. However, the training sets differ in terms of their power to detect underlying risk variants, and therefore the derived PRS differ in terms of the variance they can explain.</p><p>It must be noted, that in the PGC-BIP, -SCZ and -MDD samples, controls are partly overlapping. However, it is unlikely that this drives the genetic correlation of BOR with those disorders as the overlap of controls in these samples is rather small (under 10%).<sup><xref ref-type="bibr" rid="bib54">54</xref></sup> Also, the joint logistic regression analysis demonstrated that polygenic risk for SCZ and MDD contributed independently to the BOR risk (see above).</p><p>The present study had several limitations. First, despite being one of the largest BOR samples available worldwide, the sample size was small in terms of the estimation of heritability. Replication of the present results is warranted in larger, independent cohorts. This should include the investigation of non-European samples. Second, no information was available on the presence of common clinical features such as psychotic symptoms and affect instability. This precluded detailed analysis of the identified genetic overlap. Future studies in larger cohorts should also investigate more detailed phenotypes, including comorbid axis I and axis II disorders, such as addiction and personality disorders, respectively. Third, the observation that psychiatric patients often establish non-random relationships with persons affected by the same or another psychiatric disorder,<sup><xref ref-type="bibr" rid="bib55">55</xref></sup> and therefore have offspring with a higher genetic risk for psychiatric disorders, might contribute to the observed genetic correlation of BOR with BIP, SCZ and MDD. However, the LD-score method does not investigate the impact of assortative mating.<sup><xref ref-type="bibr" rid="bib32">32</xref></sup> Therefore, assessment of the degree to which this phenomenon may have influenced the genetic correlation estimates was beyond the scope of the present study.</p><p>Despite these limitations, the results indicate that neither comorbidity with MDD nor risk variants that are exclusive to MDD explain the genetic overlap between BOR and BIP, SCZ and MDD. Future investigations of larger data sets for BOR and other psychiatric disorders are warranted to refine the analysis of shared and specific genetic risk.</p><p>Future studies are warranted to delineate the communalities and specificities of the respective disorders.</p></sec><sec><title>Conclusion</title><p>In summary, the present study is the first GWAS of patients diagnosed with BOR. The results suggest promising novel genes and a novel pathway for BOR, and demonstrate that, rather than being a discrete entity, BOR has an etiological overlap with the major psychoses. The genetic overlap with BIP is consistent with the observation that some diagnostic criteria for BOR overlap with those for BIP. The overlap between BOR and SCZ and MDD is consistent with previous observations of genetic overlap of other psychiatric disorders.<sup><xref ref-type="bibr" rid="bib56">56</xref></sup> Given that BOR patients display specific clinical symptoms not observed in patients with other psychiatric disorders, knowledge of shared and non-shared genetic and clinical features will be important for the development of personalized treatment approaches.</p></sec></body><back><ack><p>We thank all patients and control subjects for their participation. We thank the KFO 256 workgroup of the CIMH, and Bipolar Disorder Working Group-, the Major Depression Working Group- and the Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC-BIP, PGC-MDD, PGC-SCZ) for providing access to the relevant data. The Romanian sample was funded by UEFISCDI, Romania, grant no. 89/2012 to MGS. The CoLaus|PsyCoLaus study was and is supported by research grants from GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne and the Swiss National Science Foundation (grants 3200B0–105993, 3200B0-118308, 33CSCO-122661, 33CS30-139468 and 33CS30-148401). The study was supported by the German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the auspices of the e:Med Programme (grant 01ZX1314A to MMN and SC; grant 01ZX1314G to MR). The study was supported by the German Research Foundation (DFG; grant FOR2107; RI908/11-1 to MR; WI3429/3-1 to SHW; NO246/10-1 to MMN; DA1151/5-1 to UD; KFO 256 BO 1487/12-1 to MB;.SFB 779 TP A08 to BHS).</p></ack><fn-group><fn><p><xref ref-type="supplementary-material" rid="sup1">Supplementary Information</xref> accompanies the paper on the Translational Psychiatry website (http://www.nature.com/tp)</p></fn><fn fn-type="COI-statement"><p>JIN Jr is an investigator for Assurex and a consultant for Janssen. AT has received consultancy fees from Janssen and Novartis. 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<volume>45</volume>: <fpage>984</fpage>–994.<pub-id pub-id-type="pmid">23933821</pub-id></mixed-citation></ref></ref-list><sec sec-type="supplementary-material" id="sup1"><title>Supplementary Material</title><supplementary-material content-type="local-data" id="xob1"><label>Supplementary Material</label><media xlink:href="tp2017115x1.doc"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></sec></back><floats-group><fig id="fig1"><label>Figure 1</label><caption><p>Quantile–Quantile plot. Quantile–Quantile plot of the case–control analysis (998 cases; 1545 controls) showing expected and observed –log10 <italic>P</italic>-values. The shaded region indicates the 95% confidence interval of expected <italic>P</italic>-values under the null hypothesis.</p></caption><graphic xlink:href="tp2017115f1"></graphic></fig><fig id="fig2"><label>Figure 2</label><caption><p>Manhattan plot showing association results. Manhattan plot of the case–control analysis (998 cases; 1545 controls). For each single-nucleotide polymorphism (SNP), the chromosomal position is shown on the <italic>x</italic> axis, and the –log10 <italic>P</italic>-value on the <italic>y</italic> axis. The red line indicates genome-wide significance (<italic>P</italic><5 × 10<sup>−8</sup>) and the blue line indicates suggestive evidence for association (<italic>P</italic><1 × 10<sup>−5</sup>).</p></caption><graphic xlink:href="tp2017115f2"></graphic></fig><fig id="fig3"><label>Figure 3</label><caption><p>Polygenic risk score analysis. The proportion of variance explained in case–control status (<italic>y</italic> axis; Nagelkerke’s <italic>R</italic><sup>2</sup>) by the PRS for BIP, SCZ and MDD is depicted for the different <italic>P</italic>-value cutoffs used in the calculation of the PRS. Principal components were included in the models to control for population stratification. 1*, <italic>P</italic><0.05; 2*, <italic>P</italic><0.001; 3*, <italic>P</italic><1 × 10<sup>−4</sup>; 4*, <italic>P</italic><1 × 10<sup>−6</sup>; 5*, <italic>P</italic><1 × 10<sup>−8</sup>; 6*, <italic>P</italic><1 × 10<sup>−10</sup>; 7*, <italic>P</italic><1 × 10<sup>−12</sup>. BIP, bipolar disorder; MDD, major depressive disorder; NS, nonsignificant; PRS, polygenic risk score; SCZ, schizophrenia.</p></caption><graphic xlink:href="tp2017115f3"></graphic></fig><fig id="fig4"><label>Figure 4</label><caption><p>Polygenic risk score analysis in subgroups. Mean z-standardized PRS and standard error (s.e.) for BIP, SCZ and MDD are shown in the control group, all cases, and in cases with and without comorbid MDD. PRS with a <italic>P</italic>-value threshold of <italic>P</italic>=0.05 were selected for this comparison and principal components were included in the models to control for population stratification. The numbers at the top of each bar indicate the significance of the difference in the respective PRS in comparison with the control group. 1*, <italic>P</italic><0.05; 2*, <italic>P</italic><0.001; 3*, <italic>P</italic><1 × 10<sup>−4</sup>; 4*, <italic>P</italic><1 × 10<sup>−6</sup>; 5*, <italic>P</italic><1 × 10<sup>−8</sup>; 6*, <italic>P</italic><1 × 10<sup>−10</sup>; 7*, <italic>P</italic><1 × 10<sup>−12</sup>. BIP, bipolar disorder; BOR, borderline personality disorder; MDD, major depressive disorder; NS, nonsignificant; PRS, polygenic risk score; SCZ, schizophrenia.</p></caption><graphic xlink:href="tp2017115f4"></graphic></fig><table-wrap id="tbl1"><label>Table 1</label><caption><title>Results of the gene-based analysis using MAGMA</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><italic>GENE</italic></th><th align="center" valign="top" char="." charoff="50"><italic>CHR</italic></th><th align="center" valign="top" char="." charoff="50"><italic>START</italic></th><th align="center" valign="top" char="." charoff="50"><italic>STOP</italic></th><th align="center" valign="top" char="." charoff="50">N<italic><sub>SNPS</sub></italic></th><th align="center" valign="top" char="." charoff="50">N<italic><sub>PARAM</sub></italic></th><th align="center" valign="top" char="." charoff="50">Z<italic><sub>STAT</sub></italic></th><th align="center" valign="top" charoff="50">P</th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50"><italic><bold>PKP4</bold></italic></td><td align="char" valign="top" char="." charoff="50">2</td><td align="char" valign="top" char="." charoff="50">159303476</td><td align="char" valign="top" char="." charoff="50">159547941</td><td align="char" valign="top" char="." charoff="50">21</td><td align="char" valign="top" char="." charoff="50">13</td><td align="char" valign="top" char="." charoff="50">4.7924</td><td align="center" valign="top" charoff="50">8.24 × 10<sup>−7</sup></td></tr><tr><td align="left" valign="top" charoff="50"><italic><bold>DPYD</bold></italic></td><td align="char" valign="top" char="." charoff="50">1</td><td align="char" valign="top" char="." charoff="50">97533299</td><td align="char" valign="top" char="." charoff="50">98396615</td><td align="char" valign="top" char="." charoff="50">105</td><td align="char" valign="top" char="." charoff="50">68</td><td align="char" valign="top" char="." charoff="50">4.7162</td><td align="center" valign="top" charoff="50">1.20 × 10<sup>−6</sup></td></tr><tr><td align="left" valign="top" charoff="50">GRAMD1B</td><td align="char" valign="top" char="." charoff="50">11</td><td align="char" valign="top" char="." charoff="50">123315191</td><td align="char" valign="top" char="." charoff="50">123508478</td><td align="char" valign="top" char="." charoff="50">34</td><td align="char" valign="top" char="." charoff="50">28</td><td align="char" valign="top" char="." charoff="50">3.8856</td><td align="center" valign="top" charoff="50">5.10 × 10<sup>−5</sup></td></tr><tr><td align="left" valign="top" charoff="50">STX8</td><td align="char" valign="top" char="." charoff="50">17</td><td align="char" valign="top" char="." charoff="50">9143788</td><td align="char" valign="top" char="." charoff="50">9489275</td><td align="char" valign="top" char="." charoff="50">38</td><td align="char" valign="top" char="." charoff="50">33</td><td align="char" valign="top" char="." charoff="50">3.7984</td><td align="center" valign="top" charoff="50">7.28 × 10<sup>−5</sup></td></tr><tr><td align="left" valign="top" charoff="50">BMP2</td><td align="char" valign="top" char="." charoff="50">20</td><td align="char" valign="top" char="." charoff="50">6738745</td><td align="char" valign="top" char="." charoff="50">6770910</td><td align="char" valign="top" char="." charoff="50">7</td><td align="char" valign="top" char="." charoff="50">6</td><td align="char" valign="top" char="." charoff="50">3.588</td><td align="center" valign="top" charoff="50">1.67 × 10<sup>−4</sup></td></tr><tr><td align="left" valign="top" charoff="50"><italic>TRAF3IP1</italic></td><td align="char" valign="top" char="." charoff="50">2</td><td align="char" valign="top" char="." charoff="50">239219185</td><td align="char" valign="top" char="." charoff="50">239319541</td><td align="char" valign="top" char="." charoff="50">11</td><td align="char" valign="top" char="." charoff="50">8</td><td align="char" valign="top" char="." charoff="50">3.5389</td><td align="center" valign="top" charoff="50">2.01 × 10<sup>−4</sup></td></tr><tr><td align="left" valign="top" charoff="50">ZP3</td><td align="char" valign="top" char="." charoff="50">7</td><td align="char" valign="top" char="." charoff="50">76016841</td><td align="char" valign="top" char="." charoff="50">76081388</td><td align="char" valign="top" char="." charoff="50">9</td><td align="char" valign="top" char="." charoff="50">7</td><td align="char" valign="top" char="." charoff="50">3.5037</td><td align="center" valign="top" charoff="50">2.29 × 10<sup>−4</sup></td></tr><tr><td align="left" valign="top" charoff="50"><italic>PINX1</italic></td><td align="char" valign="top" char="." charoff="50">8</td><td align="char" valign="top" char="." charoff="50">10612473</td><td align="char" valign="top" char="." charoff="50">10707394</td><td align="char" valign="top" char="." charoff="50">19</td><td align="char" valign="top" char="." charoff="50">11</td><td align="char" valign="top" char="." charoff="50">3.5034</td><td align="center" valign="top" charoff="50">2.30 × 10<sup>−4</sup></td></tr><tr><td align="left" valign="top" charoff="50">GTF3C4</td><td align="char" valign="top" char="." charoff="50">9</td><td align="char" valign="top" char="." charoff="50">135535728</td><td align="char" valign="top" char="." charoff="50">135575471</td><td align="char" valign="top" char="." charoff="50">4</td><td align="char" valign="top" char="." charoff="50">4</td><td align="char" valign="top" char="." charoff="50">3.4851</td><td align="center" valign="top" charoff="50">2.46 × 10<sup>−4</sup></td></tr><tr><td align="left" valign="top" charoff="50">DNAH1</td><td align="char" valign="top" char="." charoff="50">3</td><td align="char" valign="top" char="." charoff="50">52340335</td><td align="char" valign="top" char="." charoff="50">52444513</td><td align="char" valign="top" char="." charoff="50">11</td><td align="char" valign="top" char="." charoff="50">8</td><td align="char" valign="top" char="." charoff="50">3.4543</td><td align="center" valign="top" charoff="50">2.76 × 10<sup>−4</sup></td></tr><tr><td align="left" valign="top" charoff="50">YKT6</td><td align="char" valign="top" char="." charoff="50">7</td><td align="char" valign="top" char="." charoff="50">44230577</td><td align="char" valign="top" char="." charoff="50">44263893</td><td align="char" valign="top" char="." charoff="50">6</td><td align="char" valign="top" char="." charoff="50">3</td><td align="char" valign="top" char="." charoff="50">3.3841</td><td align="center" valign="top" charoff="50">3.57 × 10<sup>−4</sup></td></tr><tr><td align="left" valign="top" charoff="50">CCSER1</td><td align="char" valign="top" char="." charoff="50">4</td><td align="char" valign="top" char="." charoff="50">91038684</td><td align="char" valign="top" char="." charoff="50">92533370</td><td align="char" valign="top" char="." charoff="50">111</td><td align="char" valign="top" char="." charoff="50">78</td><td align="char" valign="top" char="." charoff="50">3.3804</td><td align="center" valign="top" charoff="50">3.62 × 10<sup>−4</sup></td></tr><tr><td align="left" valign="top" charoff="50">LRRC59</td><td align="char" valign="top" char="." charoff="50">17</td><td align="char" valign="top" char="." charoff="50">48448594</td><td align="char" valign="top" char="." charoff="50">48484914</td><td align="char" valign="top" char="." charoff="50">8</td><td align="char" valign="top" char="." charoff="50">6</td><td align="char" valign="top" char="." charoff="50">3.3716</td><td align="center" valign="top" charoff="50">3.74 × 10<sup>−4</sup></td></tr><tr><td align="left" valign="top" charoff="50">TMEM71</td><td align="char" valign="top" char="." charoff="50">8</td><td align="char" valign="top" char="." charoff="50">133712191</td><td align="char" valign="top" char="." charoff="50">133782914</td><td align="char" valign="top" char="." charoff="50">9</td><td align="char" valign="top" char="." charoff="50">8</td><td align="char" valign="top" char="." charoff="50">3.3668</td><td align="center" valign="top" charoff="50">3.80 × 10<sup>−4</sup></td></tr><tr><td align="left" valign="top" charoff="50">BAP1</td><td align="char" valign="top" char="." charoff="50">3</td><td align="char" valign="top" char="." charoff="50">52425020</td><td align="char" valign="top" char="." charoff="50">52454121</td><td align="char" valign="top" char="." charoff="50">3</td><td align="char" valign="top" char="." charoff="50">3</td><td align="char" valign="top" char="." charoff="50">3.345</td><td align="center" valign="top" charoff="50">4.11 × 10<sup>−4</sup></td></tr><tr><td align="left" valign="top" charoff="50">AQR</td><td align="char" valign="top" char="." charoff="50">15</td><td align="char" valign="top" char="." charoff="50">35138552</td><td align="char" valign="top" char="." charoff="50">35271995</td><td align="char" valign="top" char="." charoff="50">8</td><td align="char" valign="top" char="." charoff="50">6</td><td align="char" valign="top" char="." charoff="50">3.3299</td><td align="center" valign="top" charoff="50">4.34 × 10<sup>−4</sup></td></tr><tr><td align="left" valign="top" charoff="50">FGFR1</td><td align="char" valign="top" char="." charoff="50">8</td><td align="char" valign="top" char="." charoff="50">38258656</td><td align="char" valign="top" char="." charoff="50">38336352</td><td align="char" valign="top" char="." charoff="50">12</td><td align="char" valign="top" char="." charoff="50">10</td><td align="char" valign="top" char="." charoff="50">3.3162</td><td align="center" valign="top" charoff="50">4.56 × 10<sup>−4</sup></td></tr></tbody></table><table-wrap-foot><fn id="t1-fn1"><p>Abbreviations: CHR, chromosome; <italic>N</italic><sub>PARAM</sub>, number of parameters used in the model; <italic>N</italic><sub>SNPS</sub>, number of single-nucleotide polymorphisms; <italic>P</italic>, <italic>P</italic>-value of gene; <italic>Z</italic><sub>STAT</sub>, <italic>z</italic>-value of the gene.</p></fn><fn id="t1-fn2"><p>Most significant genes (<italic>P</italic><5 × 10<sup>−4</sup>) in the gene-based analysis and their chromosomal position. Genes in bold font were significant after correction for multiple testing.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tbl2"><label>Table 2</label><caption><title>Results of the gene-set analysis</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><italic>Gene-set name</italic></th><th align="center" valign="top" char="." charoff="50"><italic>Number of genes</italic></th><th align="center" valign="top" char="." charoff="50">P<italic>-value</italic></th><th align="center" valign="top" char="." charoff="50"><italic>FDR</italic> P<italic>-value</italic></th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50"><bold>GO: EXOCYTOSIS</bold></td><td align="char" valign="top" char="." charoff="50"><bold>25</bold></td><td align="char" valign="top" char="." charoff="50"><bold>0.001</bold></td><td align="char" valign="top" char="." charoff="50"><bold>0.019</bold></td></tr><tr><td align="left" valign="top" charoff="50">GO: RESPONSE TO ORGANIC SUBSTANCE</td><td align="char" valign="top" char="." charoff="50">30</td><td align="char" valign="top" char="." charoff="50">0.002</td><td align="char" valign="top" char="." charoff="50">0.173</td></tr><tr><td align="left" valign="top" charoff="50">GO: BRAIN DEVELOPMENT</td><td align="char" valign="top" char="." charoff="50">51</td><td align="char" valign="top" char="." charoff="50">0.003</td><td align="char" valign="top" char="." charoff="50">0.888</td></tr><tr><td align="left" valign="top" charoff="50">GO: HORMONE METABOLIC PROCESS</td><td align="char" valign="top" char="." charoff="50">30</td><td align="char" valign="top" char="." charoff="50">0.003</td><td align="char" valign="top" char="." charoff="50">0.511</td></tr><tr><td align="left" valign="top" charoff="50">GO: PROTEIN C TERMINUS BINDING</td><td align="char" valign="top" char="." charoff="50">73</td><td align="char" valign="top" char="." charoff="50">0.003</td><td align="char" valign="top" char="." charoff="50">0.536</td></tr><tr><td align="left" valign="top" charoff="50">GO: LYSOSOME</td><td align="char" valign="top" char="." charoff="50">53</td><td align="char" valign="top" char="." charoff="50">0.007</td><td align="char" valign="top" char="." charoff="50">0.785</td></tr><tr><td align="left" valign="top" charoff="50">GO: LYTIC VACUOLE</td><td align="char" valign="top" char="." charoff="50">53</td><td align="char" valign="top" char="." charoff="50">0.007</td><td align="char" valign="top" char="." charoff="50">0.785</td></tr><tr><td align="left" valign="top" charoff="50">GO: MULTI-ORGANISM PROCESS</td><td align="char" valign="top" char="." charoff="50">143</td><td align="char" valign="top" char="." charoff="50">0.007</td><td align="char" valign="top" char="." charoff="50">0.920</td></tr></tbody></table><table-wrap-foot><fn id="t2-fn1"><p>Abbreviations: FDR, false discovery rate; GO, Gene Ontology; <italic>P</italic>-value, gene-set <italic>P</italic>-value.</p></fn><fn id="t2-fn2"><p>Most significant gene sets (uncorrected <italic>P</italic><0.01) in the gene-set analysis with i-GSEA4GWASv2 are listed. Gene sets in bold font were significant after correction for multiple testing.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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