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Novel genetic loci associated with hippocampal volume

Identifieur interne : 000784 ( Pmc/Corpus ); précédent : 000783; suivant : 000785

Novel genetic loci associated with hippocampal volume

Auteurs : Derrek P. Hibar ; Hieab H. H. Adams ; Neda Jahanshad ; Ganesh Chauhan ; Jason L. Stein ; Edith Hofer ; Miguel E. Renteria ; Joshua C. Bis ; Alejandro Arias-Vasquez ; M. Kamran Ikram ; Sylvane Desrivières ; Meike W. Vernooij ; Lucija Abramovic ; Saud Alhusaini ; Najaf Amin ; Micael Andersson ; Konstantinos Arfanakis ; Benjamin S. Aribisala ; Nicola J. Armstrong ; Lavinia Athanasiu ; Tomas Axelsson ; Ashley H. Beecham ; Alexa Beiser ; Manon Bernard ; Susan H. Blanton ; Marc M. Bohlken ; Marco P. Boks ; Janita Bralten ; Adam M. Brickman ; Owen Carmichael ; M. Mallar Chakravarty ; Qiang Chen ; Christopher R. K. Ching ; Vincent Chouraki ; Gabriel Cuellar-Partida ; Fabrice Crivello ; Anouk Den Braber ; Nhat Trung Doan ; Stefan Ehrlich ; Sudheer Giddaluru ; Aaron L. Goldman ; Rebecca F. Gottesman ; Oliver Grimm ; Michael E. Griswold ; Tulio Guadalupe ; Boris A. Gutman ; Johanna Hass ; Unn K. Haukvik ; David Hoehn ; Avram J. Holmes ; Martine Hoogman ; Deborah Janowitz ; Tianye Jia ; Kjetil N. J Rgensen ; Nazanin Karbalai ; Dalia Kasperaviciute ; Sungeun Kim ; Marieke Klein ; Bernd Kraemer ; Phil H. Lee ; David C. M. Liewald ; Lorna M. Lopez ; Michelle Luciano ; Christine Macare ; Andre F. Marquand ; Mar Matarin ; Karen A. Mather ; Manuel Mattheisen ; David R. Mckay ; Yuri Milaneschi ; Susana Mu Oz Maniega ; Kwangsik Nho ; Allison C. Nugent ; Paul Nyquist ; Loes M. Olde Loohuis ; Jaap Oosterlaan ; Martina Papmeyer ; Lukas Pirpamer ; Benno Pütz ; Adaikalavan Ramasamy ; Jennifer S. Richards ; Shannon L. Risacher ; Roberto Roiz-Santia Ez ; Nanda Rommelse ; Stefan Ropele ; Emma J. Rose ; Natalie A. Royle ; Tatjana Rundek ; Philipp G. S Mann ; Arvin Saremi ; Claudia L. Satizabal ; Lianne Schmaal ; Andrew J. Schork ; Li Shen ; Jean Shin ; Elena Shumskaya ; Albert V. Smith ; Emma Sprooten ; Lachlan T. Strike ; Alexander Teumer ; Diana Tordesillas-Gutierrez ; Roberto Toro ; Daniah Trabzuni ; Stella Trompet ; Dhananjay Vaidya ; Jeroen Van Der Grond ; Sven J. Van Der Lee ; Dennis Van Der Meer ; Marjolein M. J. Van Donkelaar ; Kristel R. Van Eijk ; Theo G. M. Van Erp ; Daan Van Rooij ; Esther Walton ; Lars T. Westlye ; Christopher D. Whelan ; Beverly G. Windham ; Anderson M. Winkler ; Katharina Wittfeld ; Girma Woldehawariat ; Christiane Wolf ; Thomas Wolfers ; Lisa R. Yanek ; Jingyun Yang ; Alex Zijdenbos ; Marcel P. Zwiers ; Ingrid Agartz ; Laura Almasy ; David Ames ; Philippe Amouyel ; Ole A. Andreassen ; Sampath Arepalli ; Amelia A. Assareh ; Sandra Barral ; Mark E. Bastin ; Diane M. Becker ; James T. Becker ; David A. Bennett ; John Blangero ; Hans Van Bokhoven ; Dorret I. Boomsma ; Henry Brodaty ; Rachel M. Brouwer ; Han G. Brunner ; Randy L. Buckner ; Jan K. Buitelaar ; Kazima B. Bulayeva ; Wiepke Cahn ; Vince D. Calhoun ; Dara M. Cannon ; Gianpiero L. Cavalleri ; Ching-Yu Cheng ; Sven Cichon ; Mark R. Cookson ; Aiden Corvin ; Benedicto Crespo-Facorro ; Joanne E. Curran ; Michael Czisch ; Anders M. Dale ; Gareth E. Davies ; Anton J. M. De Craen ; Eco J. C. De Geus ; Philip L. De Jager ; Greig I. De Zubicaray ; Ian J. Deary ; Stéphanie Debette ; Charles Decarli ; Norman Delanty ; Chantal Depondt ; Anita Destefano ; Allissa Dillman ; Srdjan Djurovic ; Gary Donohoe ; Wayne C. Drevets ; Ravi Duggirala ; Thomas D. Dyer ; Christian Enzinger ; Susanne Erk ; Thomas Espeseth ; Iryna O. Fedko ; Guillén Fernández ; Luigi Ferrucci ; Simon E. Fisher ; Debra A. Fleischman ; Ian Ford ; Myriam Fornage ; Tatiana M. Foroud ; Peter T. Fox ; Clyde Francks ; Masaki Fukunaga ; J. Raphael Gibbs ; David C. Glahn ; Randy L. Gollub ; Harald H. H. Göring ; Robert C. Green ; Oliver Gruber ; Vilmundur Gudnason ; Sebastian Guelfi ; Asta K. H Berg ; Narelle K. Hansell ; John Hardy ; Catharina A. Hartman ; Ryota Hashimoto ; Katrin Hegenscheid ; Andreas Heinz ; Stephanie Le Hellard ; Dena G. Hernandez ; Dirk J. Heslenfeld ; Beng-Choon Ho ; Pieter J. Hoekstra ; Wolfgang Hoffmann ; Albert Hofman ; Florian Holsboer ; Georg Homuth ; Norbert Hosten ; Jouke-Jan Hottenga ; Matthew Huentelman ; Hilleke E. Hulshoff Pol ; Masashi Ikeda ; Clifford R. Jack Jr ; Mark Jenkinson ; Robert Johnson ; Erik G. Jönsson ; J. Wouter Jukema ; René S. Kahn ; Ryota Kanai ; Iwona Kloszewska ; David S. Knopman ; Peter Kochunov ; John B. Kwok ; Stephen M. Lawrie ; Hervé Lemaître ; Xinmin Liu ; Dan L. Longo ; Oscar L. Lopez ; Simon Lovestone ; Oliver Martinez ; Jean-Luc Martinot ; Venkata S. Mattay ; Colm Mcdonald ; Andrew M. Mcintosh ; Francis J. Mcmahon ; Katie L. Mcmahon ; Patrizia Mecocci ; Ingrid Melle ; Andreas Meyer-Lindenberg ; Sebastian Mohnke ; Grant W. Montgomery ; Derek W. Morris ; Thomas H. Mosley ; Thomas W. Mühleisen ; Bertram Müller-Myhsok ; Michael A. Nalls ; Matthias Nauck ; Thomas E. Nichols ; Wiro J. Niessen ; Markus M. Nöthen ; Lars Nyberg ; Kazutaka Ohi ; Rene L. Olvera ; Roel A. Ophoff ; Massimo Pandolfo ; Tomas Paus ; Zdenka Pausova ; Brenda W. J. H. Penninx ; G. Bruce Pike ; Steven G. Potkin ; Bruce M. Psaty ; Simone Reppermund ; Marcella Rietschel ; Joshua L. Roffman ; Nina Romanczuk-Seiferth ; Jerome I. Rotter ; Mina Ryten ; Ralph L. Sacco ; Perminder S. Sachdev ; Andrew J. Saykin ; Reinhold Schmidt ; Helena Schmidt ; Peter R. Schofield ; Sigurdur Sigursson ; Andrew Simmons ; Andrew Singleton ; Sanjay M. Sisodiya ; Colin Smith ; Jordan W. Smoller ; Hilkka Soininen ; Vidar M. Steen ; David J. Stott ; Jessika E. Sussmann ; Anbupalam Thalamuthu ; Arthur W. Toga ; Bryan J. Traynor ; Juan Troncoso ; Magda Tsolaki ; Christophe Tzourio ; Andre G. Uitterlinden ; Maria C. Valdés Hernández ; Marcel Van Der Brug ; Aad Van Der Lugt ; Nic J. A. Van Der Wee ; Neeltje E. M. Van Haren ; Dennis Van T Ent ; Marie-Jose Van Tol ; Badri N. Vardarajan ; Bruno Vellas ; Dick J. Veltman ; Henry Völzke ; Henrik Walter ; Joanna M. Wardlaw ; Thomas H. Wassink ; Michael E. Weale ; Daniel R. Weinberger ; Michael W. Weiner ; Wei Wen ; Eric Westman ; Tonya White ; Tien Y. Wong ; Clinton B. Wright ; Ronald H. Zielke ; Alan B. Zonderman ; Nicholas G. Martin ; Cornelia M. Van Duijn ; Margaret J. Wright ; W. T. Longstreth ; Gunter Schumann ; Hans J. Grabe ; Barbara Franke ; Lenore J. Launer ; Sarah E. Medland ; Sudha Seshadri ; Paul M. Thompson ; M. Arfan Ikram

Source :

RBID : PMC:5253632

Abstract

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=−0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.


Url:
DOI: 10.1038/ncomms13624
PubMed: 28098162
PubMed Central: 5253632

Links to Exploration step

PMC:5253632

Le document en format XML

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<name sortKey="Abramovic, Lucija" sort="Abramovic, Lucija" uniqKey="Abramovic L" first="Lucija" last="Abramovic">Lucija Abramovic</name>
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<name sortKey="Andersson, Micael" sort="Andersson, Micael" uniqKey="Andersson M" first="Micael" last="Andersson">Micael Andersson</name>
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<name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name>
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<nlm:aff id="a24">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
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<institution>Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center</institution>
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<name sortKey="Aribisala, Benjamin S" sort="Aribisala, Benjamin S" uniqKey="Aribisala B" first="Benjamin S." last="Aribisala">Benjamin S. Aribisala</name>
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<nlm:aff id="a27">
<institution>Department of Computer Science, Lagos State University</institution>
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<country>Nigeria</country>
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<affiliation>
<nlm:aff id="a28">
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<name sortKey="Armstrong, Nicola J" sort="Armstrong, Nicola J" uniqKey="Armstrong N" first="Nicola J." last="Armstrong">Nicola J. Armstrong</name>
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<name sortKey="Athanasiu, Lavinia" sort="Athanasiu, Lavinia" uniqKey="Athanasiu L" first="Lavinia" last="Athanasiu">Lavinia Athanasiu</name>
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<nlm:aff id="a32">
<institution>NORMENT—KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital</institution>
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<author>
<name sortKey="Axelsson, Tomas" sort="Axelsson, Tomas" uniqKey="Axelsson T" first="Tomas" last="Axelsson">Tomas Axelsson</name>
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<institution>Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University</institution>
, Box 1432, SE-751 44 Uppsala,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Beecham, Ashley H" sort="Beecham, Ashley H" uniqKey="Beecham A" first="Ashley H." last="Beecham">Ashley H. Beecham</name>
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<nlm:aff id="a34">
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</affiliation>
<affiliation>
<nlm:aff id="a35">
<institution>John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine</institution>
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<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name>
<affiliation>
<nlm:aff id="a36">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, Massachusetts,02118,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a37">
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, Massachusetts 02118
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a38">
<institution>Framingham Heart Study</institution>
, 17 Mount Wayte Avenue, Framingham, Massachusetts 01703
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</affiliation>
</author>
<author>
<name sortKey="Bernard, Manon" sort="Bernard, Manon" uniqKey="Bernard M" first="Manon" last="Bernard">Manon Bernard</name>
<affiliation>
<nlm:aff id="a39">
<institution>Hospital for Sick Children, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M5G 1X8</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Blanton, Susan H" sort="Blanton, Susan H" uniqKey="Blanton S" first="Susan H." last="Blanton">Susan H. Blanton</name>
<affiliation>
<nlm:aff id="a34">
<institution>Dr John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a35">
<institution>John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bohlken, Marc M" sort="Bohlken, Marc M" uniqKey="Bohlken M" first="Marc M." last="Bohlken">Marc M. Bohlken</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Boks, Marco P" sort="Boks, Marco P" uniqKey="Boks M" first="Marco P." last="Boks">Marco P. Boks</name>
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<nlm:aff id="a19">
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<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bralten, Janita" sort="Bralten, Janita" uniqKey="Bralten J" first="Janita" last="Bralten">Janita Bralten</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Brickman, Adam M" sort="Brickman, Adam M" uniqKey="Brickman A" first="Adam M." last="Brickman">Adam M. Brickman</name>
<affiliation>
<nlm:aff id="a40">
<institution>Taub Institute for Research on Alzheimer's Disease and the Aging Brain; G.H. Sergievsky Center; Department of Neurology. Columbia University Medical Center</institution>
, 639 West 1168th Street, New York, New York 10032,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Carmichael, Owen" sort="Carmichael, Owen" uniqKey="Carmichael O" first="Owen" last="Carmichael">Owen Carmichael</name>
<affiliation>
<nlm:aff id="a41">
<institution>Pennington Biomedical Research Center</institution>
, Baton Rouge, Louisiana 70808,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chakravarty, M Mallar" sort="Chakravarty, M Mallar" uniqKey="Chakravarty M" first="M. Mallar" last="Chakravarty">M. Mallar Chakravarty</name>
<affiliation>
<nlm:aff id="a42">
<institution>Cerebral Imaging Centre, Douglas Mental Health University Institute</institution>
, Montreal, Quebec, Canada H4H 1R3</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a43">
<institution>Department of Psychiatry and Biomedical Engineering, McGill University</institution>
, Montreal, Quebec,
<country>Canada</country>
H3A 2B4</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chen, Qiang" sort="Chen, Qiang" uniqKey="Chen Q" first="Qiang" last="Chen">Qiang Chen</name>
<affiliation>
<nlm:aff id="a44">
<institution>Lieber Institute for Brain Development</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ching, Christopher R K" sort="Ching, Christopher R K" uniqKey="Ching C" first="Christopher R. K." last="Ching">Christopher R. K. Ching</name>
<affiliation>
<nlm:aff id="a1">
<institution>Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California</institution>
, Los Angeles, California 90292,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a45">
<institution>Interdepartmental Neuroscience Graduate Program, UCLA School of Medicine</institution>
, Los Angeles, California 90095,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name>
<affiliation>
<nlm:aff id="a36">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, Massachusetts,02118,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a38">
<institution>Framingham Heart Study</institution>
, 17 Mount Wayte Avenue, Framingham, Massachusetts 01703
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a46">
<institution>Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167—RID-AGE—Risk factors and molecular determinants of aging-related diseases</institution>
, F-59000 Lille,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cuellar Partida, Gabriel" sort="Cuellar Partida, Gabriel" uniqKey="Cuellar Partida G" first="Gabriel" last="Cuellar-Partida">Gabriel Cuellar-Partida</name>
<affiliation>
<nlm:aff id="a8">
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name>
<affiliation>
<nlm:aff id="a47">
<institution>IMN UMR5293, GIN, CNRS, CEA, University of Bordeaux</institution>
, 146 rue Léo Saignat, 33076 Bordeaux,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name>
<affiliation>
<nlm:aff id="a48">
<institution>Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Doan, Nhat Trung" sort="Doan, Nhat Trung" uniqKey="Doan N" first="Nhat Trung" last="Doan">Nhat Trung Doan</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ehrlich, Stefan" sort="Ehrlich, Stefan" uniqKey="Ehrlich S" first="Stefan" last="Ehrlich">Stefan Ehrlich</name>
<affiliation>
<nlm:aff id="a49">
<institution>Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden</institution>
, 01307 Dresden,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a51">
<institution>Martinos Center for Biomedical Imaging, Massachusetts General Hospital</institution>
, Charlestown, Massachusetts 02129,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Giddaluru, Sudheer" sort="Giddaluru, Sudheer" uniqKey="Giddaluru S" first="Sudheer" last="Giddaluru">Sudheer Giddaluru</name>
<affiliation>
<nlm:aff id="a52">
<institution>NORMENT—KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a53">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Goldman, Aaron L" sort="Goldman, Aaron L" uniqKey="Goldman A" first="Aaron L." last="Goldman">Aaron L. Goldman</name>
<affiliation>
<nlm:aff id="a44">
<institution>Lieber Institute for Brain Development</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gottesman, Rebecca F" sort="Gottesman, Rebecca F" uniqKey="Gottesman R" first="Rebecca F." last="Gottesman">Rebecca F. Gottesman</name>
<affiliation>
<nlm:aff id="a54">
<institution>Department of Neurology, Johns Hopkins University School of Medicine</institution>
, Baltimore, Maryland 21287,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Grimm, Oliver" sort="Grimm, Oliver" uniqKey="Grimm O" first="Oliver" last="Grimm">Oliver Grimm</name>
<affiliation>
<nlm:aff id="a55">
<institution>Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg</institution>
, 68159 Mannheim,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Griswold, Michael E" sort="Griswold, Michael E" uniqKey="Griswold M" first="Michael E." last="Griswold">Michael E. Griswold</name>
<affiliation>
<nlm:aff id="a56">
<institution>Department of Data Science, University of Mississippi Medical Center</institution>
, Jackson, Mississippi, 39216,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Guadalupe, Tulio" sort="Guadalupe, Tulio" uniqKey="Guadalupe T" first="Tulio" last="Guadalupe">Tulio Guadalupe</name>
<affiliation>
<nlm:aff id="a57">
<institution>Language and Genetics Department, Max Planck Institute for Psycholinguistics</institution>
, 6525 XD Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a58">
<institution>International Max Planck Research School for Language Sciences</institution>
, 6525 XD Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gutman, Boris A" sort="Gutman, Boris A" uniqKey="Gutman B" first="Boris A." last="Gutman">Boris A. Gutman</name>
<affiliation>
<nlm:aff id="a1">
<institution>Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California</institution>
, Los Angeles, California 90292,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hass, Johanna" sort="Hass, Johanna" uniqKey="Hass J" first="Johanna" last="Hass">Johanna Hass</name>
<affiliation>
<nlm:aff id="a59">
<institution>Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden</institution>
, 01307 Dresden,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Haukvik, Unn K" sort="Haukvik, Unn K" uniqKey="Haukvik U" first="Unn K." last="Haukvik">Unn K. Haukvik</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a60">
<institution>Department of Research and Development, Diakonhjemmet Hospital</institution>
, 0319 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hoehn, David" sort="Hoehn, David" uniqKey="Hoehn D" first="David" last="Hoehn">David Hoehn</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Holmes, Avram J" sort="Holmes, Avram J" uniqKey="Holmes A" first="Avram J." last="Holmes">Avram J. Holmes</name>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a62">
<institution>Department of Psychology, Yale University</institution>
, New Haven, Connecticut 06520,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hoogman, Martine" sort="Hoogman, Martine" uniqKey="Hoogman M" first="Martine" last="Hoogman">Martine Hoogman</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Janowitz, Deborah" sort="Janowitz, Deborah" uniqKey="Janowitz D" first="Deborah" last="Janowitz">Deborah Janowitz</name>
<affiliation>
<nlm:aff id="a63">
<institution>Department of Psychiatry, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Jia, Tianye" sort="Jia, Tianye" uniqKey="Jia T" first="Tianye" last="Jia">Tianye Jia</name>
<affiliation>
<nlm:aff id="a18">
<institution>MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="J Rgensen, Kjetil N" sort="J Rgensen, Kjetil N" uniqKey="J Rgensen K" first="Kjetil N." last="J Rgensen">Kjetil N. J Rgensen</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a60">
<institution>Department of Research and Development, Diakonhjemmet Hospital</institution>
, 0319 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Karbalai, Nazanin" sort="Karbalai, Nazanin" uniqKey="Karbalai N" first="Nazanin" last="Karbalai">Nazanin Karbalai</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kasperaviciute, Dalia" sort="Kasperaviciute, Dalia" uniqKey="Kasperaviciute D" first="Dalia" last="Kasperaviciute">Dalia Kasperaviciute</name>
<affiliation>
<nlm:aff id="a64">
<institution>UCL Institute of Neurology, London, United Kingdom and Epilepsy Society</institution>
, Bucks, SL9 0RJ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a65">
<institution>Department of Medicine, Imperial College London</institution>
, London SW7 2AZ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kim, Sungeun" sort="Kim, Sungeun" uniqKey="Kim S" first="Sungeun" last="Kim">Sungeun Kim</name>
<affiliation>
<nlm:aff id="a66">
<institution>Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a67">
<institution>Center for Computational Biology and Bioinformatics, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a68">
<institution>Indiana Alzheimer Disease Center, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Klein, Marieke" sort="Klein, Marieke" uniqKey="Klein M" first="Marieke" last="Klein">Marieke Klein</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kraemer, Bernd" sort="Kraemer, Bernd" uniqKey="Kraemer B" first="Bernd" last="Kraemer">Bernd Kraemer</name>
<affiliation>
<nlm:aff id="a69">
<institution>Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University</institution>
, Heidelberg, 69120,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lee, Phil H" sort="Lee, Phil H" uniqKey="Lee P" first="Phil H." last="Lee">Phil H. Lee</name>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a70">
<institution>Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a71">
<institution>Harvard Medical School</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a72">
<institution>Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard</institution>
, Boston, Massachusetts 02141,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a73">
<institution>Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School</institution>
, Lexington, Massachusetts, 02421,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Liewald, David C M" sort="Liewald, David C M" uniqKey="Liewald D" first="David C. M." last="Liewald">David C. M. Liewald</name>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Luciano, Michelle" sort="Luciano, Michelle" uniqKey="Luciano M" first="Michelle" last="Luciano">Michelle Luciano</name>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Macare, Christine" sort="Macare, Christine" uniqKey="Macare C" first="Christine" last="Macare">Christine Macare</name>
<affiliation>
<nlm:aff id="a18">
<institution>MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Marquand, Andre F" sort="Marquand, Andre F" uniqKey="Marquand A" first="Andre F." last="Marquand">Andre F. Marquand</name>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a75">
<institution>Donders Centre for Cognitive Neuroimaging, Radboud University</institution>
, Nijmegen, 6525 EN,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Matarin, Mar" sort="Matarin, Mar" uniqKey="Matarin M" first="Mar" last="Matarin">Mar Matarin</name>
<affiliation>
<nlm:aff id="a64">
<institution>UCL Institute of Neurology, London, United Kingdom and Epilepsy Society</institution>
, Bucks, SL9 0RJ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mather, Karen A" sort="Mather, Karen A" uniqKey="Mather K" first="Karen A." last="Mather">Karen A. Mather</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name>
<affiliation>
<nlm:aff id="a77">
<institution>Department of Biomedicine, Aarhus University</institution>
, DK-8000 Aarhus,
<country>Denmark</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a78">
<institution>The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</institution>
, DK-8000 Aarhus and Copenhagen,
<country>Denmark</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a79">
<institution>Center for integrated Sequencing, iSEQ, Aarhus University</institution>
, DK-8000 Aarhus,
<country>Denmark</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mckay, David R" sort="Mckay, David R" uniqKey="Mckay D" first="David R." last="Mckay">David R. Mckay</name>
<affiliation>
<nlm:aff id="a80">
<institution>Department of Psychiatry, Yale University</institution>
, New Haven, Connecticut 06511,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a81">
<institution>Olin Neuropsychiatric Research Center</institution>
, Hartford, Connecticut 06114,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Milaneschi, Yuri" sort="Milaneschi, Yuri" uniqKey="Milaneschi Y" first="Yuri" last="Milaneschi">Yuri Milaneschi</name>
<affiliation>
<nlm:aff id="a82">
<institution>Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest</institution>
, 1081 HL Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mu Oz Maniega, Susana" sort="Mu Oz Maniega, Susana" uniqKey="Mu Oz Maniega S" first="Susana" last="Mu Oz Maniega">Susana Mu Oz Maniega</name>
<affiliation>
<nlm:aff id="a26">
<institution>Brain Research Imaging Centre, University of Edinburgh</institution>
, Edinburgh EH4 2XU,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a28">
<institution>Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nho, Kwangsik" sort="Nho, Kwangsik" uniqKey="Nho K" first="Kwangsik" last="Nho">Kwangsik Nho</name>
<affiliation>
<nlm:aff id="a66">
<institution>Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a67">
<institution>Center for Computational Biology and Bioinformatics, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a68">
<institution>Indiana Alzheimer Disease Center, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nugent, Allison C" sort="Nugent, Allison C" uniqKey="Nugent A" first="Allison C." last="Nugent">Allison C. Nugent</name>
<affiliation>
<nlm:aff id="a83">
<institution>Human Genetics Branch, National Institute of Mental Health Intramural Research Program</institution>
, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nyquist, Paul" sort="Nyquist, Paul" uniqKey="Nyquist P" first="Paul" last="Nyquist">Paul Nyquist</name>
<affiliation>
<nlm:aff id="a84">
<institution>Department of Neurology, Department of Anesthesia/Critical Care Medicine, Department of Neurosurgery, Johns Hopkins</institution>
, USA600 N. Wolfe St, Baltimore, Maryland 21287,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Loohuis, Loes M Olde" sort="Loohuis, Loes M Olde" uniqKey="Loohuis L" first="Loes M. Olde" last="Loohuis">Loes M. Olde Loohuis</name>
<affiliation>
<nlm:aff id="a85">
<institution>Center for Neurobehavioral Genetics, University of California</institution>
, Los Angeles, California 90095,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Oosterlaan, Jaap" sort="Oosterlaan, Jaap" uniqKey="Oosterlaan J" first="Jaap" last="Oosterlaan">Jaap Oosterlaan</name>
<affiliation>
<nlm:aff id="a86">
<institution>Department of Clinical Neuropsychology, VU University Amsterdam</institution>
, Amsterdam, 1081 HV,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Papmeyer, Martina" sort="Papmeyer, Martina" uniqKey="Papmeyer M" first="Martina" last="Papmeyer">Martina Papmeyer</name>
<affiliation>
<nlm:aff id="a87">
<institution>Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh</institution>
, Edinburgh EH10 5HF,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a88">
<institution>Division of Systems Neuroscience of Psychopathology, Translational Research Center, University Hospital of Psychiatry, University of Bern</institution>
, Bern, 3060,
<country>Switzerland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pirpamer, Lukas" sort="Pirpamer, Lukas" uniqKey="Pirpamer L" first="Lukas" last="Pirpamer">Lukas Pirpamer</name>
<affiliation>
<nlm:aff id="a6">
<institution>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz</institution>
, Auenbruggerplatz 22, 8036 Graz,
<country>Austria</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Putz, Benno" sort="Putz, Benno" uniqKey="Putz B" first="Benno" last="Pütz">Benno Pütz</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a89">
<institution>Department of Medical and Molecular Genetics, King's College London</institution>
, London SE1 9RT,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a90">
<institution>The Jenner Institute Laboratories, University of Oxford</institution>
, Oxford OX3 7DQ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Richards, Jennifer S" sort="Richards, Jennifer S" uniqKey="Richards J" first="Jennifer S." last="Richards">Jennifer S. Richards</name>
<affiliation>
<nlm:aff id="a12">
<institution>Department of Cognitive Neuroscience, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a91">
<institution>Karakter Child and Adolescent Psychiatry University Center</institution>
, Nijmegen, 6525 GC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Risacher, Shannon L" sort="Risacher, Shannon L" uniqKey="Risacher S" first="Shannon L." last="Risacher">Shannon L. Risacher</name>
<affiliation>
<nlm:aff id="a66">
<institution>Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a68">
<institution>Indiana Alzheimer Disease Center, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Roiz Santia Ez, Roberto" sort="Roiz Santia Ez, Roberto" uniqKey="Roiz Santia Ez R" first="Roberto" last="Roiz-Santia Ez">Roberto Roiz-Santia Ez</name>
<affiliation>
<nlm:aff id="a92">
<institution>Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL</institution>
, 39008 Santander,
<country>Spain</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a93">
<institution>CIBERSAM (Centro Investigación Biomédica en Red Salud Mental)</institution>
, Santander, 39011,
<country>Spain</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rommelse, Nanda" sort="Rommelse, Nanda" uniqKey="Rommelse N" first="Nanda" last="Rommelse">Nanda Rommelse</name>
<affiliation>
<nlm:aff id="a11">
<institution>Department of Psychiatry, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a91">
<institution>Karakter Child and Adolescent Psychiatry University Center</institution>
, Nijmegen, 6525 GC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ropele, Stefan" sort="Ropele, Stefan" uniqKey="Ropele S" first="Stefan" last="Ropele">Stefan Ropele</name>
<affiliation>
<nlm:aff id="a6">
<institution>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz</institution>
, Auenbruggerplatz 22, 8036 Graz,
<country>Austria</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rose, Emma J" sort="Rose, Emma J" uniqKey="Rose E" first="Emma J." last="Rose">Emma J. Rose</name>
<affiliation>
<nlm:aff id="a94">
<institution>Psychosis Research Group, Department of Psychiatry & Trinity Translational Medicine Institute, Trinity College</institution>
, Dublin, Dublin 2,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Royle, Natalie A" sort="Royle, Natalie A" uniqKey="Royle N" first="Natalie A." last="Royle">Natalie A. Royle</name>
<affiliation>
<nlm:aff id="a26">
<institution>Brain Research Imaging Centre, University of Edinburgh</institution>
, Edinburgh EH4 2XU,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a28">
<institution>Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a95">
<institution>Centre for Clinical Brain Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rundek, Tatjana" sort="Rundek, Tatjana" uniqKey="Rundek T" first="Tatjana" last="Rundek">Tatjana Rundek</name>
<affiliation>
<nlm:aff id="a96">
<institution>Department of Neurology, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a97">
<institution>Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="S Mann, Philipp G" sort="S Mann, Philipp G" uniqKey="S Mann P" first="Philipp G." last="S Mann">Philipp G. S Mann</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Saremi, Arvin" sort="Saremi, Arvin" uniqKey="Saremi A" first="Arvin" last="Saremi">Arvin Saremi</name>
<affiliation>
<nlm:aff id="a1">
<institution>Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California</institution>
, Los Angeles, California 90292,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Satizabal, Claudia L" sort="Satizabal, Claudia L" uniqKey="Satizabal C" first="Claudia L." last="Satizabal">Claudia L. Satizabal</name>
<affiliation>
<nlm:aff id="a36">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, Massachusetts,02118,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a38">
<institution>Framingham Heart Study</institution>
, 17 Mount Wayte Avenue, Framingham, Massachusetts 01703
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Schmaal, Lianne" sort="Schmaal, Lianne" uniqKey="Schmaal L" first="Lianne" last="Schmaal">Lianne Schmaal</name>
<affiliation>
<nlm:aff id="a98">
<institution>Orygen, The National Centre of Excellence in Youth Mental Health</institution>
, Melbourne, Victoria, 3502,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a99">
<institution>Centre for Youth Mental Health, The University of Melbourne</institution>
, Melbourne, Victoria, 3502,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a100">
<institution>Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center</institution>
, 1007 MB Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Schork, Andrew J" sort="Schork, Andrew J" uniqKey="Schork A" first="Andrew J." last="Schork">Andrew J. Schork</name>
<affiliation>
<nlm:aff id="a101">
<institution>Multimodal Imaging Laboratory, Department of Neurosciences, University of California</institution>
, San Diego, California 92093,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a102">
<institution>Department of Cognitive Sciences, University of California</institution>
, San Diego, California 92161,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Shen, Li" sort="Shen, Li" uniqKey="Shen L" first="Li" last="Shen">Li Shen</name>
<affiliation>
<nlm:aff id="a66">
<institution>Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a67">
<institution>Center for Computational Biology and Bioinformatics, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a68">
<institution>Indiana Alzheimer Disease Center, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Shin, Jean" sort="Shin, Jean" uniqKey="Shin J" first="Jean" last="Shin">Jean Shin</name>
<affiliation>
<nlm:aff id="a39">
<institution>Hospital for Sick Children, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M5G 1X8</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Shumskaya, Elena" sort="Shumskaya, Elena" uniqKey="Shumskaya E" first="Elena" last="Shumskaya">Elena Shumskaya</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a75">
<institution>Donders Centre for Cognitive Neuroimaging, Radboud University</institution>
, Nijmegen, 6525 EN,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
<affiliation>
<nlm:aff id="a103">
<institution>Icelandic Heart Association</institution>
, Kopavogur, 201,
<country>Iceland</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a104">
<institution>Faculty of Medicine, University of Iceland</institution>
, Reykjavik, 101,
<country>Iceland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sprooten, Emma" sort="Sprooten, Emma" uniqKey="Sprooten E" first="Emma" last="Sprooten">Emma Sprooten</name>
<affiliation>
<nlm:aff id="a80">
<institution>Department of Psychiatry, Yale University</institution>
, New Haven, Connecticut 06511,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a81">
<institution>Olin Neuropsychiatric Research Center</institution>
, Hartford, Connecticut 06114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a105">
<institution>Department of Psychiatry, Icahn School of Medicine at Mount Sinai</institution>
, New York, New York, 10029,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Strike, Lachlan T" sort="Strike, Lachlan T" uniqKey="Strike L" first="Lachlan T." last="Strike">Lachlan T. Strike</name>
<affiliation>
<nlm:aff id="a8">
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a106">
<institution>Queensland Brain Institute, University of Queensland</institution>
, Brisbane, Queensland 4072,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name>
<affiliation>
<nlm:aff id="a107">
<institution>Institute for Community Medicine, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Tordesillas Gutierrez, Diana" sort="Tordesillas Gutierrez, Diana" uniqKey="Tordesillas Gutierrez D" first="Diana" last="Tordesillas-Gutierrez">Diana Tordesillas-Gutierrez</name>
<affiliation>
<nlm:aff id="a93">
<institution>CIBERSAM (Centro Investigación Biomédica en Red Salud Mental)</institution>
, Santander, 39011,
<country>Spain</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a108">
<institution>Neuroimaging Unit, Technological Facilities. Valdecilla Biomedical Research Institute IDIVAL</institution>
, Santander, Cantabria, 39011,
<country>Spain</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Toro, Roberto" sort="Toro, Roberto" uniqKey="Toro R" first="Roberto" last="Toro">Roberto Toro</name>
<affiliation>
<nlm:aff id="a109">
<institution>Institut Pasteur</institution>
, 75015 Paris,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Trabzuni, Daniah" sort="Trabzuni, Daniah" uniqKey="Trabzuni D" first="Daniah" last="Trabzuni">Daniah Trabzuni</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a110">
<institution>Department of Genetics, King Faisal Specialist Hospital and Research Centre</institution>
, Riyadh 11211,
<country>Saudi Arabia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name>
<affiliation>
<nlm:aff id="a111">
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden, 2300RC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Vaidya, Dhananjay" sort="Vaidya, Dhananjay" uniqKey="Vaidya D" first="Dhananjay" last="Vaidya">Dhananjay Vaidya</name>
<affiliation>
<nlm:aff id="a112">
<institution>GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine</institution>
, 1830 E Monument St Suite 8028, Baltimore, Maryland 21287,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Der Grond, Jeroen" sort="Van Der Grond, Jeroen" uniqKey="Van Der Grond J" first="Jeroen" last="Van Der Grond">Jeroen Van Der Grond</name>
<affiliation>
<nlm:aff id="a113">
<institution>Department of Radiology, Leiden University Medical Center</institution>
, Leiden, 2300RC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Der Lee, Sven J" sort="Van Der Lee, Sven J" uniqKey="Van Der Lee S" first="Sven J." last="Van Der Lee">Sven J. Van Der Lee</name>
<affiliation>
<nlm:aff id="a2">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Der Meer, Dennis" sort="Van Der Meer, Dennis" uniqKey="Van Der Meer D" first="Dennis" last="Van Der Meer">Dennis Van Der Meer</name>
<affiliation>
<nlm:aff id="a114">
<institution>Department of Psychiatry, University of Groningen, University Medical Center Groningen</institution>
, Groningen, 9700RB,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Donkelaar, Marjolein M J" sort="Van Donkelaar, Marjolein M J" uniqKey="Van Donkelaar M" first="Marjolein M. J." last="Van Donkelaar">Marjolein M. J. Van Donkelaar</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Eijk, Kristel R" sort="Van Eijk, Kristel R" uniqKey="Van Eijk K" first="Kristel R." last="Van Eijk">Kristel R. Van Eijk</name>
<affiliation>
<nlm:aff id="a115">
<institution>Brain Center Rudolf Magnus, Human Neurogenetics Unit, UMC Utrecht</institution>
, 3584 CG Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Erp, Theo G M" sort="Van Erp, Theo G M" uniqKey="Van Erp T" first="Theo G. M." last="Van Erp">Theo G. M. Van Erp</name>
<affiliation>
<nlm:aff id="a116">
<institution>Department of Psychiatry and Human Behavior, University of California-Irvine</institution>
, Irvine, California 92617,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Rooij, Daan" sort="Van Rooij, Daan" uniqKey="Van Rooij D" first="Daan" last="Van Rooij">Daan Van Rooij</name>
<affiliation>
<nlm:aff id="a12">
<institution>Department of Cognitive Neuroscience, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a114">
<institution>Department of Psychiatry, University of Groningen, University Medical Center Groningen</institution>
, Groningen, 9700RB,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Walton, Esther" sort="Walton, Esther" uniqKey="Walton E" first="Esther" last="Walton">Esther Walton</name>
<affiliation>
<nlm:aff id="a49">
<institution>Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden</institution>
, 01307 Dresden,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a117">
<institution>Department of Psychology, Georgia State University</institution>
, Atlanta, Georgia 30302,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Westlye, Lars T" sort="Westlye, Lars T" uniqKey="Westlye L" first="Lars T." last="Westlye">Lars T. Westlye</name>
<affiliation>
<nlm:aff id="a32">
<institution>NORMENT—KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital</institution>
, 0424 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a117">
<institution>Department of Psychology, Georgia State University</institution>
, Atlanta, Georgia 30302,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Whelan, Christopher D" sort="Whelan, Christopher D" uniqKey="Whelan C" first="Christopher D." last="Whelan">Christopher D. Whelan</name>
<affiliation>
<nlm:aff id="a1">
<institution>Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California</institution>
, Los Angeles, California 90292,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a21">
<institution>The Royal College of Surgeons in Ireland</institution>
, 123 St Stephen's Green, Dublin 2,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Windham, Beverly G" sort="Windham, Beverly G" uniqKey="Windham B" first="Beverly G." last="Windham">Beverly G. Windham</name>
<affiliation>
<nlm:aff id="a118">
<institution>NORMENT—KG Jebsen Centre, Department of Psychology, University of Oslo</institution>
, 0317 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Winkler, Anderson M" sort="Winkler, Anderson M" uniqKey="Winkler A" first="Anderson M." last="Winkler">Anderson M. Winkler</name>
<affiliation>
<nlm:aff id="a80">
<institution>Department of Psychiatry, Yale University</institution>
, New Haven, Connecticut 06511,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a119">
<institution>Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, Mississippi, 39216,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wittfeld, Katharina" sort="Wittfeld, Katharina" uniqKey="Wittfeld K" first="Katharina" last="Wittfeld">Katharina Wittfeld</name>
<affiliation>
<nlm:aff id="a63">
<institution>Department of Psychiatry, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a120">
<institution>FMRIB Centre, University of Oxford</institution>
, Oxford OX3 9DU,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Woldehawariat, Girma" sort="Woldehawariat, Girma" uniqKey="Woldehawariat G" first="Girma" last="Woldehawariat">Girma Woldehawariat</name>
<affiliation>
<nlm:aff id="a83">
<institution>Human Genetics Branch, National Institute of Mental Health Intramural Research Program</institution>
, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wolf, Christiane" sort="Wolf, Christiane" uniqKey="Wolf C" first="Christiane" last="Wolf">Christiane Wolf</name>
<affiliation>
<nlm:aff id="a121">
<institution>German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald</institution>
, 17487 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wolfers, Thomas" sort="Wolfers, Thomas" uniqKey="Wolfers T" first="Thomas" last="Wolfers">Thomas Wolfers</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Yanek, Lisa R" sort="Yanek, Lisa R" uniqKey="Yanek L" first="Lisa R." last="Yanek">Lisa R. Yanek</name>
<affiliation>
<nlm:aff id="a112">
<institution>GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine</institution>
, 1830 E Monument St Suite 8028, Baltimore, Maryland 21287,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Yang, Jingyun" sort="Yang, Jingyun" uniqKey="Yang J" first="Jingyun" last="Yang">Jingyun Yang</name>
<affiliation>
<nlm:aff id="a24">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, Illinois 60612,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a122">
<institution>University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy</institution>
, Wuerzburg, 97080,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name>
<affiliation>
<nlm:aff id="a123">
<institution>Department of Neurological Sciences, Rush University Medical Center</institution>
, Chicago, Illinois 60612,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zwiers, Marcel P" sort="Zwiers, Marcel P" uniqKey="Zwiers M" first="Marcel P." last="Zwiers">Marcel P. Zwiers</name>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a75">
<institution>Donders Centre for Cognitive Neuroimaging, Radboud University</institution>
, Nijmegen, 6525 EN,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Agartz, Ingrid" sort="Agartz, Ingrid" uniqKey="Agartz I" first="Ingrid" last="Agartz">Ingrid Agartz</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a60">
<institution>Department of Research and Development, Diakonhjemmet Hospital</institution>
, 0319 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a124">
<institution>Biospective Inc, Montreal, Quebec, Canada</institution>
, 6100 Avenue Royalmount, Montréal, Québec,
<country>Canada</country>
H4P 2R2</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Almasy, Laura" sort="Almasy, Laura" uniqKey="Almasy L" first="Laura" last="Almasy">Laura Almasy</name>
<affiliation>
<nlm:aff id="a125">
<institution>Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet</institution>
, SE-171 77 Stockholm,
<country>Sweden</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a126">
<institution>South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine</institution>
, Brownsville/Edinburg/San Antonio, Texas, 78250,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a127">
<institution>Department of Genetics, Perelman School of Medicine, University of Pennsylvania</institution>
, Philadelphia, Pennsylvania 19104,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name>
<affiliation>
<nlm:aff id="a128">
<institution>Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia</institution>
, Philadelphia, Pennsylvania 29104,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a129">
<institution>National Ageing Research Institute, Royal Melbourne Hospital</institution>
, Melbourne, Victoria 3052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation>
<nlm:aff id="a46">
<institution>Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167—RID-AGE—Risk factors and molecular determinants of aging-related diseases</institution>
, F-59000 Lille,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Andreassen, Ole A" sort="Andreassen, Ole A" uniqKey="Andreassen O" first="Ole A." last="Andreassen">Ole A. Andreassen</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a32">
<institution>NORMENT—KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital</institution>
, 0424 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Arepalli, Sampath" sort="Arepalli, Sampath" uniqKey="Arepalli S" first="Sampath" last="Arepalli">Sampath Arepalli</name>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Assareh, Amelia A" sort="Assareh, Amelia A" uniqKey="Assareh A" first="Amelia A." last="Assareh">Amelia A. Assareh</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Barral, Sandra" sort="Barral, Sandra" uniqKey="Barral S" first="Sandra" last="Barral">Sandra Barral</name>
<affiliation>
<nlm:aff id="a40">
<institution>Taub Institute for Research on Alzheimer's Disease and the Aging Brain; G.H. Sergievsky Center; Department of Neurology. Columbia University Medical Center</institution>
, 639 West 1168th Street, New York, New York 10032,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name>
<affiliation>
<nlm:aff id="a26">
<institution>Brain Research Imaging Centre, University of Edinburgh</institution>
, Edinburgh EH4 2XU,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a28">
<institution>Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a95">
<institution>Centre for Clinical Brain Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Becker, Diane M" sort="Becker, Diane M" uniqKey="Becker D" first="Diane M." last="Becker">Diane M. Becker</name>
<affiliation>
<nlm:aff id="a112">
<institution>GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine</institution>
, 1830 E Monument St Suite 8028, Baltimore, Maryland 21287,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T." last="Becker">James T. Becker</name>
<affiliation>
<nlm:aff id="a131">
<institution>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health</institution>
, Bethesda, Maryland 20892,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<affiliation>
<nlm:aff id="a24">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, Illinois 60612,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a122">
<institution>University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy</institution>
, Wuerzburg, 97080,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name>
<affiliation>
<nlm:aff id="a125">
<institution>Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet</institution>
, SE-171 77 Stockholm,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Bokhoven, Hans" sort="Van Bokhoven, Hans" uniqKey="Van Bokhoven H" first="Hans" last="Van Bokhoven">Hans Van Bokhoven</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name>
<affiliation>
<nlm:aff id="a48">
<institution>Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Brodaty, Henry" sort="Brodaty, Henry" uniqKey="Brodaty H" first="Henry" last="Brodaty">Henry Brodaty</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a132">
<institution>Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh</institution>
, 3501 Forbes Ave., Suite 830, Pittsburgh, Pennsylvania 15213,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Brouwer, Rachel M" sort="Brouwer, Rachel M" uniqKey="Brouwer R" first="Rachel M." last="Brouwer">Rachel M. Brouwer</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Brunner, Han G" sort="Brunner, Han G" uniqKey="Brunner H" first="Han G." last="Brunner">Han G. Brunner</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a133">
<institution>Dementia Collaborative Research Centre—Assessment and Better Care, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Buckner, Randy L" sort="Buckner, Randy L" uniqKey="Buckner R" first="Randy L." last="Buckner">Randy L. Buckner</name>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a134">
<institution>Department of Clinical Genetics and GROW School for Oncology and Developmental Biology, Maastricht University Medical Center</institution>
, 6200 MD Maastricht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Buitelaar, Jan K" sort="Buitelaar, Jan K" uniqKey="Buitelaar J" first="Jan K." last="Buitelaar">Jan K. Buitelaar</name>
<affiliation>
<nlm:aff id="a12">
<institution>Department of Cognitive Neuroscience, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a91">
<institution>Karakter Child and Adolescent Psychiatry University Center</institution>
, Nijmegen, 6525 GC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bulayeva, Kazima B" sort="Bulayeva, Kazima B" uniqKey="Bulayeva K" first="Kazima B." last="Bulayeva">Kazima B. Bulayeva</name>
<affiliation>
<nlm:aff id="a135">
<institution>Department of Psychology, Center for Brain Science, Harvard University</institution>
, Cambridge, Massachusetts 02138,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cahn, Wiepke" sort="Cahn, Wiepke" uniqKey="Cahn W" first="Wiepke" last="Cahn">Wiepke Cahn</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Calhoun, Vince D" sort="Calhoun, Vince D" uniqKey="Calhoun V" first="Vince D." last="Calhoun">Vince D. Calhoun</name>
<affiliation>
<nlm:aff id="a136">
<institution>Department of Evolution and Genetics, Dagestan State University</institution>
, Makhachkala 367000, Dagestan,
<country>Russia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a137">
<institution>The Mind Research Network & LBERI</institution>
, Albuquerque, New Mexico 87106,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cannon, Dara M" sort="Cannon, Dara M" uniqKey="Cannon D" first="Dara M." last="Cannon">Dara M. Cannon</name>
<affiliation>
<nlm:aff id="a83">
<institution>Human Genetics Branch, National Institute of Mental Health Intramural Research Program</institution>
, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a138">
<institution>Department of ECE, University of New Mexico</institution>
, Albuquerque, New Mexico 87131,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cavalleri, Gianpiero L" sort="Cavalleri, Gianpiero L" uniqKey="Cavalleri G" first="Gianpiero L." last="Cavalleri">Gianpiero L. Cavalleri</name>
<affiliation>
<nlm:aff id="a21">
<institution>The Royal College of Surgeons in Ireland</institution>
, 123 St Stephen's Green, Dublin 2,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name>
<affiliation>
<nlm:aff id="a14">
<institution>Academic Medicine Research Institute, Duke-NUS Graduate Medical School</institution>
, Singapore, 169857,
<country>Singapore</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a15">
<institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>
, Singapore, 168751,
<country>Singapore</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a139">
<institution>Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway</institution>
, H91 TK33 Galway,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name>
<affiliation>
<nlm:aff id="a140">
<institution>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</institution>
, Singapore, 119077,
<country>Singapore</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a141">
<institution>Division of Medical Genetics, Department of Biomedicine, University of Basel</institution>
, 4031 Basel,
<country>Switzerland</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a142">
<institution>Institute of Human Genetics, University of Bonn</institution>
, 53127 Bonn,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cookson, Mark R" sort="Cookson, Mark R" uniqKey="Cookson M" first="Mark R." last="Cookson">Mark R. Cookson</name>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Corvin, Aiden" sort="Corvin, Aiden" uniqKey="Corvin A" first="Aiden" last="Corvin">Aiden Corvin</name>
<affiliation>
<nlm:aff id="a94">
<institution>Psychosis Research Group, Department of Psychiatry & Trinity Translational Medicine Institute, Trinity College</institution>
, Dublin, Dublin 2,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Crespo Facorro, Benedicto" sort="Crespo Facorro, Benedicto" uniqKey="Crespo Facorro B" first="Benedicto" last="Crespo-Facorro">Benedicto Crespo-Facorro</name>
<affiliation>
<nlm:aff id="a92">
<institution>Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL</institution>
, 39008 Santander,
<country>Spain</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a93">
<institution>CIBERSAM (Centro Investigación Biomédica en Red Salud Mental)</institution>
, Santander, 39011,
<country>Spain</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Curran, Joanne E" sort="Curran, Joanne E" uniqKey="Curran J" first="Joanne E." last="Curran">Joanne E. Curran</name>
<affiliation>
<nlm:aff id="a125">
<institution>Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet</institution>
, SE-171 77 Stockholm,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Czisch, Michael" sort="Czisch, Michael" uniqKey="Czisch M" first="Michael" last="Czisch">Michael Czisch</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Dale, Anders M" sort="Dale, Anders M" uniqKey="Dale A" first="Anders M." last="Dale">Anders M. Dale</name>
<affiliation>
<nlm:aff id="a143">
<institution>Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich</institution>
, 52425 Jülich,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a144">
<institution>Center for Multimodal Imaging and Genetics, University of California</institution>
, San Diego, California 92093,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Davies, Gareth E" sort="Davies, Gareth E" uniqKey="Davies G" first="Gareth E." last="Davies">Gareth E. Davies</name>
<affiliation>
<nlm:aff id="a145">
<institution>Departments of Neurosciences, Radiology, Psychiatry, and Cognitive Science, University of California</institution>
, San Diego, California 92093,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J. M." last="De Craen">Anton J. M. De Craen</name>
<affiliation>
<nlm:aff id="a146">
<institution>Avera Institute for Human Genetics</institution>
, Sioux Falls, South Dakota 57108,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name>
<affiliation>
<nlm:aff id="a48">
<institution>Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L." last="De Jager">Philip L. De Jager</name>
<affiliation>
<nlm:aff id="a71">
<institution>Harvard Medical School</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a147">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden, 2300RC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a148">
<institution>Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Brigham and Women's Hospital</institution>
, Boston, Massachusetts, 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a149">
<institution>Harvard Medical School</institution>
, Boston, Massachusetts, 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a150">
<institution>Program in Medical and Population Genetics, Broad Institute</institution>
, Cambridge, Massachusetts, 02142,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="De Zubicaray, Greig I" sort="De Zubicaray, Greig I" uniqKey="De Zubicaray G" first="Greig I." last="De Zubicaray">Greig I. De Zubicaray</name>
<affiliation>
<nlm:aff id="a151">
<institution>Broad Institute</institution>
, Cambridge, Massachusetts, 02142,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stéphanie" last="Debette">Stéphanie Debette</name>
<affiliation>
<nlm:aff id="a4">
<institution>INSERM Unit U1219, University of Bordeaux</institution>
, 33076 Bordeaux,
<country>France</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a36">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, Massachusetts,02118,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a152">
<institution>Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT)</institution>
, Brisbane, Queensland 4059,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name>
<affiliation>
<nlm:aff id="a153">
<institution>Department of Neurology, Bordeaux University Hospital</institution>
, Bordeaux, 33076,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Delanty, Norman" sort="Delanty, Norman" uniqKey="Delanty N" first="Norman" last="Delanty">Norman Delanty</name>
<affiliation>
<nlm:aff id="a21">
<institution>The Royal College of Surgeons in Ireland</institution>
, 123 St Stephen's Green, Dublin 2,
<country>Ireland</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a154">
<institution>Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis</institution>
, 4860 Y Street, Suite 3700, Sacramento, California 95817,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Depondt, Chantal" sort="Depondt, Chantal" uniqKey="Depondt C" first="Chantal" last="Depondt">Chantal Depondt</name>
<affiliation>
<nlm:aff id="a155">
<institution>Neurology Division, Beaumont Hospital</institution>
, Dublin 9,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name>
<affiliation>
<nlm:aff id="a37">
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, Massachusetts 02118
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a38">
<institution>Framingham Heart Study</institution>
, 17 Mount Wayte Avenue, Framingham, Massachusetts 01703
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Dillman, Allissa" sort="Dillman, Allissa" uniqKey="Dillman A" first="Allissa" last="Dillman">Allissa Dillman</name>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Djurovic, Srdjan" sort="Djurovic, Srdjan" uniqKey="Djurovic S" first="Srdjan" last="Djurovic">Srdjan Djurovic</name>
<affiliation>
<nlm:aff id="a52">
<institution>NORMENT—KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a156">
<institution>Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles</institution>
, 1070 Brussels,
<country>Belgium</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Donohoe, Gary" sort="Donohoe, Gary" uniqKey="Donohoe G" first="Gary" last="Donohoe">Gary Donohoe</name>
<affiliation>
<nlm:aff id="a157">
<institution>Department of Medical Genetics, Oslo University Hospital</institution>
, 0420 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a158">
<institution>Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition & Genomics Centre (NICOG) & NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway</institution>
, H91 TK33, Galway,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Drevets, Wayne C" sort="Drevets, Wayne C" uniqKey="Drevets W" first="Wayne C." last="Drevets">Wayne C. Drevets</name>
<affiliation>
<nlm:aff id="a83">
<institution>Human Genetics Branch, National Institute of Mental Health Intramural Research Program</institution>
, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a159">
<institution>Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College Dublin</institution>
, Dublin 8,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Duggirala, Ravi" sort="Duggirala, Ravi" uniqKey="Duggirala R" first="Ravi" last="Duggirala">Ravi Duggirala</name>
<affiliation>
<nlm:aff id="a125">
<institution>Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet</institution>
, SE-171 77 Stockholm,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Dyer, Thomas D" sort="Dyer, Thomas D" uniqKey="Dyer T" first="Thomas D." last="Dyer">Thomas D. Dyer</name>
<affiliation>
<nlm:aff id="a125">
<institution>Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet</institution>
, SE-171 77 Stockholm,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Enzinger, Christian" sort="Enzinger, Christian" uniqKey="Enzinger C" first="Christian" last="Enzinger">Christian Enzinger</name>
<affiliation>
<nlm:aff id="a6">
<institution>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz</institution>
, Auenbruggerplatz 22, 8036 Graz,
<country>Austria</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Erk, Susanne" sort="Erk, Susanne" uniqKey="Erk S" first="Susanne" last="Erk">Susanne Erk</name>
<affiliation>
<nlm:aff id="a160">
<institution>Janssen Research & Development, LLC</institution>
, Titusville, New Jersey 08560,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Espeseth, Thomas" sort="Espeseth, Thomas" uniqKey="Espeseth T" first="Thomas" last="Espeseth">Thomas Espeseth</name>
<affiliation>
<nlm:aff id="a32">
<institution>NORMENT—KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital</institution>
, 0424 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a117">
<institution>Department of Psychology, Georgia State University</institution>
, Atlanta, Georgia 30302,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fedko, Iryna O" sort="Fedko, Iryna O" uniqKey="Fedko I" first="Iryna O." last="Fedko">Iryna O. Fedko</name>
<affiliation>
<nlm:aff id="a48">
<institution>Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fernandez, Guillen" sort="Fernandez, Guillen" uniqKey="Fernandez G" first="Guillén" last="Fernández">Guillén Fernández</name>
<affiliation>
<nlm:aff id="a12">
<institution>Department of Cognitive Neuroscience, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<affiliation>
<nlm:aff id="a161">
<institution>Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Department of Psychiatry and Psychotherapy</institution>
, Charitéplatz 1, 10117 Berlin,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fisher, Simon E" sort="Fisher, Simon E" uniqKey="Fisher S" first="Simon E." last="Fisher">Simon E. Fisher</name>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a57">
<institution>Language and Genetics Department, Max Planck Institute for Psycholinguistics</institution>
, 6525 XD Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fleischman, Debra A" sort="Fleischman, Debra A" uniqKey="Fleischman D" first="Debra A." last="Fleischman">Debra A. Fleischman</name>
<affiliation>
<nlm:aff id="a24">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, Illinois 60612,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a162">
<institution>Intramural Research Program of the National Institute on Aging</institution>
, Baltimore, Maryland, 21224,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation>
<nlm:aff id="a163">
<institution>Department of Neurological Sciences & Department of Behavioral Sciences, Rush University Medical Center</institution>
, Chicago, Illinois 60616,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation>
<nlm:aff id="a164">
<institution>Robertson Centre for Biostatistics, University of Glasgow</institution>
, Glasgow, G41 4DQ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M." last="Foroud">Tatiana M. Foroud</name>
<affiliation>
<nlm:aff id="a68">
<institution>Indiana Alzheimer Disease Center, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a165">
<institution>Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston</institution>
, Houston, Texas, 77030,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fox, Peter T" sort="Fox, Peter T" uniqKey="Fox P" first="Peter T." last="Fox">Peter T. Fox</name>
<affiliation>
<nlm:aff id="a166">
<institution>Medical and Molecular Genetics, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Francks, Clyde" sort="Francks, Clyde" uniqKey="Francks C" first="Clyde" last="Francks">Clyde Francks</name>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a57">
<institution>Language and Genetics Department, Max Planck Institute for Psycholinguistics</institution>
, 6525 XD Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fukunaga, Masaki" sort="Fukunaga, Masaki" uniqKey="Fukunaga M" first="Masaki" last="Fukunaga">Masaki Fukunaga</name>
<affiliation>
<nlm:aff id="a167">
<institution>University of Texas Health Science Center</institution>
, San Antonio, Texas 78229,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gibbs, J Raphael" sort="Gibbs, J Raphael" uniqKey="Gibbs J" first="J. Raphael" last="Gibbs">J. Raphael Gibbs</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C." last="Glahn">David C. Glahn</name>
<affiliation>
<nlm:aff id="a80">
<institution>Department of Psychiatry, Yale University</institution>
, New Haven, Connecticut 06511,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a81">
<institution>Olin Neuropsychiatric Research Center</institution>
, Hartford, Connecticut 06114,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gollub, Randy L" sort="Gollub, Randy L" uniqKey="Gollub R" first="Randy L." last="Gollub">Randy L. Gollub</name>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a51">
<institution>Martinos Center for Biomedical Imaging, Massachusetts General Hospital</institution>
, Charlestown, Massachusetts 02129,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a71">
<institution>Harvard Medical School</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Goring, Harald H H" sort="Goring, Harald H H" uniqKey="Goring H" first="Harald H. H." last="Göring">Harald H. H. Göring</name>
<affiliation>
<nlm:aff id="a125">
<institution>Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet</institution>
, SE-171 77 Stockholm,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Green, Robert C" sort="Green, Robert C" uniqKey="Green R" first="Robert C." last="Green">Robert C. Green</name>
<affiliation>
<nlm:aff id="a71">
<institution>Harvard Medical School</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a168">
<institution>Division of Cerebral Integration, National Institute for Physiological Sciences</institution>
, Aichi, 444-8585,
<country>Japan</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gruber, Oliver" sort="Gruber, Oliver" uniqKey="Gruber O" first="Oliver" last="Gruber">Oliver Gruber</name>
<affiliation>
<nlm:aff id="a69">
<institution>Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University</institution>
, Heidelberg, 69120,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation>
<nlm:aff id="a103">
<institution>Icelandic Heart Association</institution>
, Kopavogur, 201,
<country>Iceland</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a104">
<institution>Faculty of Medicine, University of Iceland</institution>
, Reykjavik, 101,
<country>Iceland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Guelfi, Sebastian" sort="Guelfi, Sebastian" uniqKey="Guelfi S" first="Sebastian" last="Guelfi">Sebastian Guelfi</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="H Berg, Asta K" sort="H Berg, Asta K" uniqKey="H Berg A" first="Asta K." last="H Berg">Asta K. H Berg</name>
<affiliation>
<nlm:aff id="a169">
<institution>Division of Genetics, Department of Medicine, Brigham and Women's Hospital</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a170">
<institution>Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU)</institution>
, Trondheim, 7491,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hansell, Narelle K" sort="Hansell, Narelle K" uniqKey="Hansell N" first="Narelle K." last="Hansell">Narelle K. Hansell</name>
<affiliation>
<nlm:aff id="a8">
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a106">
<institution>Queensland Brain Institute, University of Queensland</institution>
, Brisbane, Queensland 4072,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hartman, Catharina A" sort="Hartman, Catharina A" uniqKey="Hartman C" first="Catharina A." last="Hartman">Catharina A. Hartman</name>
<affiliation>
<nlm:aff id="a114">
<institution>Department of Psychiatry, University of Groningen, University Medical Center Groningen</institution>
, Groningen, 9700RB,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hashimoto, Ryota" sort="Hashimoto, Ryota" uniqKey="Hashimoto R" first="Ryota" last="Hashimoto">Ryota Hashimoto</name>
<affiliation>
<nlm:aff id="a171">
<institution>Department of Radiology, St. Olav's Hospital, Trondheim University Hospital</institution>
, Trondheim, 7030,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a172">
<institution>Department of Psychiatry, Osaka University Graduate School of Medicine</institution>
, Osaka 565-0871,
<country>Japan</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hegenscheid, Katrin" sort="Hegenscheid, Katrin" uniqKey="Hegenscheid K" first="Katrin" last="Hegenscheid">Katrin Hegenscheid</name>
<affiliation>
<nlm:aff id="a173">
<institution>Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University</institution>
, Osaka, 565-0871,
<country>Japan</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Heinz, Andreas" sort="Heinz, Andreas" uniqKey="Heinz A" first="Andreas" last="Heinz">Andreas Heinz</name>
<affiliation>
<nlm:aff id="a160">
<institution>Janssen Research & Development, LLC</institution>
, Titusville, New Jersey 08560,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Le Hellard, Stephanie" sort="Le Hellard, Stephanie" uniqKey="Le Hellard S" first="Stephanie" last="Le Hellard">Stephanie Le Hellard</name>
<affiliation>
<nlm:aff id="a52">
<institution>NORMENT—KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a53">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena G." last="Hernandez">Dena G. Hernandez</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a174">
<institution>Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Heslenfeld, Dirk J" sort="Heslenfeld, Dirk J" uniqKey="Heslenfeld D" first="Dirk J." last="Heslenfeld">Dirk J. Heslenfeld</name>
<affiliation>
<nlm:aff id="a175">
<institution>German Center for Neurodegenerative Diseases (DZNE)</institution>
, Tübingen, 72076,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ho, Beng Choon" sort="Ho, Beng Choon" uniqKey="Ho B" first="Beng-Choon" last="Ho">Beng-Choon Ho</name>
<affiliation>
<nlm:aff id="a176">
<institution>Department of Psychology, VU University Amsterdam</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hoekstra, Pieter J" sort="Hoekstra, Pieter J" uniqKey="Hoekstra P" first="Pieter J." last="Hoekstra">Pieter J. Hoekstra</name>
<affiliation>
<nlm:aff id="a114">
<institution>Department of Psychiatry, University of Groningen, University Medical Center Groningen</institution>
, Groningen, 9700RB,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hoffmann, Wolfgang" sort="Hoffmann, Wolfgang" uniqKey="Hoffmann W" first="Wolfgang" last="Hoffmann">Wolfgang Hoffmann</name>
<affiliation>
<nlm:aff id="a107">
<institution>Institute for Community Medicine, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a120">
<institution>FMRIB Centre, University of Oxford</institution>
, Oxford OX3 9DU,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation>
<nlm:aff id="a178">
<institution>Department of Epidemiology, Harvard T.H. Chan School of Public Health</institution>
, Boston, Massachusetts 02115
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Holsboer, Florian" sort="Holsboer, Florian" uniqKey="Holsboer F" first="Florian" last="Holsboer">Florian Holsboer</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a177">
<institution>Department of Psychiatry, University of Iowa</institution>
, Iowa City, Iowa 52242,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name>
<affiliation>
<nlm:aff id="a178">
<institution>Department of Epidemiology, Harvard T.H. Chan School of Public Health</institution>
, Boston, Massachusetts 02115
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hosten, Norbert" sort="Hosten, Norbert" uniqKey="Hosten N" first="Norbert" last="Hosten">Norbert Hosten</name>
<affiliation>
<nlm:aff id="a173">
<institution>Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University</institution>
, Osaka, 565-0871,
<country>Japan</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name>
<affiliation>
<nlm:aff id="a48">
<institution>Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Huentelman, Matthew" sort="Huentelman, Matthew" uniqKey="Huentelman M" first="Matthew" last="Huentelman">Matthew Huentelman</name>
<affiliation>
<nlm:aff id="a179">
<institution>HMNC Brain Health</institution>
, Munich, 80539,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pol, Hilleke E Hulshoff" sort="Pol, Hilleke E Hulshoff" uniqKey="Pol H" first="Hilleke E. Hulshoff" last="Pol">Hilleke E. Hulshoff Pol</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ikeda, Masashi" sort="Ikeda, Masashi" uniqKey="Ikeda M" first="Masashi" last="Ikeda">Masashi Ikeda</name>
<affiliation>
<nlm:aff id="a180">
<institution>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Jack Jr, Clifford R" sort="Jack Jr, Clifford R" uniqKey="Jack Jr C" first="Clifford R." last="Jack Jr">Clifford R. Jack Jr</name>
<affiliation>
<nlm:aff id="a181">
<institution>Translational Genomics Research Institute, Neurogenomics Division</institution>
, 445N Fifth Street, Phoenix, Arizona 85004,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Jenkinson, Mark" sort="Jenkinson, Mark" uniqKey="Jenkinson M" first="Mark" last="Jenkinson">Mark Jenkinson</name>
<affiliation>
<nlm:aff id="a119">
<institution>Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, Mississippi, 39216,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Johnson, Robert" sort="Johnson, Robert" uniqKey="Johnson R" first="Robert" last="Johnson">Robert Johnson</name>
<affiliation>
<nlm:aff id="a182">
<institution>Department of Psychiatry, Fujita Health University School of Medicine</institution>
, Toyoake 470-1192,
<country>Japan</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Jonsson, Erik G" sort="Jonsson, Erik G" uniqKey="Jonsson E" first="Erik G." last="Jönsson">Erik G. Jönsson</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a124">
<institution>Biospective Inc, Montreal, Quebec, Canada</institution>
, 6100 Avenue Royalmount, Montréal, Québec,
<country>Canada</country>
H4P 2R2</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<affiliation>
<nlm:aff id="a111">
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden, 2300RC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kahn, Rene S" sort="Kahn, Rene S" uniqKey="Kahn R" first="René S." last="Kahn">René S. Kahn</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kanai, Ryota" sort="Kanai, Ryota" uniqKey="Kanai R" first="Ryota" last="Kanai">Ryota Kanai</name>
<affiliation>
<nlm:aff id="a183">
<institution>Department of Radiology, Mayo Clinic</institution>
, Rochester, Minnesota 55905,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a184">
<institution>NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School</institution>
, Baltimore, Maryland 21201,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a185">
<institution>School of Psychology, University of Sussex</institution>
, Brighton BN1 9QH,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kloszewska">Iwona Kloszewska</name>
<affiliation>
<nlm:aff id="a186">
<institution>Institute of Cognitive Neuroscience, University College London</institution>
, London WC1N 3AR,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S." last="Knopman">David S. Knopman</name>
<affiliation>
<nlm:aff id="a187">
<institution>Department of Neuroinformatics, Araya Brain Imaging</institution>
, Tokyo, 102-0093,
<country>Japan</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kochunov, Peter" sort="Kochunov, Peter" uniqKey="Kochunov P" first="Peter" last="Kochunov">Peter Kochunov</name>
<affiliation>
<nlm:aff id="a188">
<institution>Medical University of Lodz</institution>
, 90-419 Lodz,
<country>Poland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kwok, John B" sort="Kwok, John B" uniqKey="Kwok J" first="John B." last="Kwok">John B. Kwok</name>
<affiliation>
<nlm:aff id="a189">
<institution>Department of Neurology, Mayo Clinic</institution>
, Rochester, Minnesota, 55905,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a190">
<institution>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine</institution>
, Baltimore, Maryland, 21228,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lawrie, Stephen M" sort="Lawrie, Stephen M" uniqKey="Lawrie S" first="Stephen M." last="Lawrie">Stephen M. Lawrie</name>
<affiliation>
<nlm:aff id="a87">
<institution>Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh</institution>
, Edinburgh EH10 5HF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaître">Hervé Lemaître</name>
<affiliation>
<nlm:aff id="a191">
<institution>Neuroscience Research Australia</institution>
, Sydney, New South Wales 2031,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Liu, Xinmin" sort="Liu, Xinmin" uniqKey="Liu X" first="Xinmin" last="Liu">Xinmin Liu</name>
<affiliation>
<nlm:aff id="a83">
<institution>Human Genetics Branch, National Institute of Mental Health Intramural Research Program</institution>
, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a192">
<institution>School of Medical Sciences, UNSW</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Longo, Dan L" sort="Longo, Dan L" uniqKey="Longo D" first="Dan L." last="Longo">Dan L. Longo</name>
<affiliation>
<nlm:aff id="a193">
<institution>INSERM UMR 1000 “Neuroimaging and Psychiatry”, Service Hospitalier Frédéric Joliot; University Paris-Sud, Université Paris-Saclay, University Paris Descartes</institution>
, Maison de Solenn, Paris, 91400,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name>
<affiliation>
<nlm:aff id="a194">
<institution>Columbia University Medical Center</institution>
, New York, New York 10032,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name>
<affiliation>
<nlm:aff id="a195">
<institution>Laboratory of Genetics, National Institute on Aging, National Institutes of Health</institution>
, Baltimore, Maryland 21224,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a196">
<institution>Departments of Neurology and Psychiatry, University of Pittsburgh</institution>
, 3501 Forbes Ave., Suite 830, Pittsburgh Pennsylvania 15213,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Martinez, Oliver" sort="Martinez, Oliver" uniqKey="Martinez O" first="Oliver" last="Martinez">Oliver Martinez</name>
<affiliation>
<nlm:aff id="a153">
<institution>Department of Neurology, Bordeaux University Hospital</institution>
, Bordeaux, 33076,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Martinot, Jean Luc" sort="Martinot, Jean Luc" uniqKey="Martinot J" first="Jean-Luc" last="Martinot">Jean-Luc Martinot</name>
<affiliation>
<nlm:aff id="a191">
<institution>Neuroscience Research Australia</institution>
, Sydney, New South Wales 2031,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mattay, Venkata S" sort="Mattay, Venkata S" uniqKey="Mattay V" first="Venkata S." last="Mattay">Venkata S. Mattay</name>
<affiliation>
<nlm:aff id="a44">
<institution>Lieber Institute for Brain Development</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a54">
<institution>Department of Neurology, Johns Hopkins University School of Medicine</institution>
, Baltimore, Maryland 21287,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a197">
<institution>Department of Psychiatry, University of Oxford</institution>
, Oxford OX3 7JX,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mcdonald, Colm" sort="Mcdonald, Colm" uniqKey="Mcdonald C" first="Colm" last="Mcdonald">Colm Mcdonald</name>
<affiliation>
<nlm:aff id="a138">
<institution>Department of ECE, University of New Mexico</institution>
, Albuquerque, New Mexico 87131,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mcintosh, Andrew M" sort="Mcintosh, Andrew M" uniqKey="Mcintosh A" first="Andrew M." last="Mcintosh">Andrew M. Mcintosh</name>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a87">
<institution>Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh</institution>
, Edinburgh EH10 5HF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mcmahon, Francis J" sort="Mcmahon, Francis J" uniqKey="Mcmahon F" first="Francis J." last="Mcmahon">Francis J. Mcmahon</name>
<affiliation>
<nlm:aff id="a83">
<institution>Human Genetics Branch, National Institute of Mental Health Intramural Research Program</institution>
, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L." last="Mcmahon">Katie L. Mcmahon</name>
<affiliation>
<nlm:aff id="a198">
<institution>Department of Radiology, Johns Hopkins University School of Medicine</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name>
<affiliation>
<nlm:aff id="a199">
<institution>Centre for Advanced Imaging, University of Queensland</institution>
, Brisbane, Queensland 4072,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Melle, Ingrid" sort="Melle, Ingrid" uniqKey="Melle I" first="Ingrid" last="Melle">Ingrid Melle</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a32">
<institution>NORMENT—KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital</institution>
, 0424 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Meyer Lindenberg, Andreas" sort="Meyer Lindenberg, Andreas" uniqKey="Meyer Lindenberg A" first="Andreas" last="Meyer-Lindenberg">Andreas Meyer-Lindenberg</name>
<affiliation>
<nlm:aff id="a55">
<institution>Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg</institution>
, 68159 Mannheim,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mohnke, Sebastian" sort="Mohnke, Sebastian" uniqKey="Mohnke S" first="Sebastian" last="Mohnke">Sebastian Mohnke</name>
<affiliation>
<nlm:aff id="a160">
<institution>Janssen Research & Development, LLC</institution>
, Titusville, New Jersey 08560,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name>
<affiliation>
<nlm:aff id="a8">
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Morris, Derek W" sort="Morris, Derek W" uniqKey="Morris D" first="Derek W." last="Morris">Derek W. Morris</name>
<affiliation>
<nlm:aff id="a157">
<institution>Department of Medical Genetics, Oslo University Hospital</institution>
, 0420 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<affiliation>
<nlm:aff id="a118">
<institution>NORMENT—KG Jebsen Centre, Department of Psychology, University of Oslo</institution>
, 0317 Oslo,
<country>Norway</country>
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</affiliation>
</author>
<author>
<name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name>
<affiliation>
<nlm:aff id="a141">
<institution>Division of Medical Genetics, Department of Biomedicine, University of Basel</institution>
, 4031 Basel,
<country>Switzerland</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a142">
<institution>Institute of Human Genetics, University of Bonn</institution>
, 53127 Bonn,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a200">
<institution>Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia</institution>
, 06132 Perugia,
<country>Italy</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a201">
<institution>Munich Cluster for Systems Neurology (SyNergy)</institution>
, 81377 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name>
<affiliation>
<nlm:aff id="a202">
<institution>University of Liverpool, Institute of Translational Medicine</institution>
, Liverpool L69 3BX,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a203">
<institution>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nichols, Thomas E" sort="Nichols, Thomas E" uniqKey="Nichols T" first="Thomas E." last="Nichols">Thomas E. Nichols</name>
<affiliation>
<nlm:aff id="a119">
<institution>Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, Mississippi, 39216,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a204">
<institution>German Center for Cardiovascular Research (DZHK e.V.), partner site Greifswald</institution>
, Greifswald, 17475,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name>
<affiliation>
<nlm:aff id="a3">
<institution>Department of Radiology and Nuclear Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a205">
<institution>Department of Statistics & WMG, University of Warwick</institution>
, Coventry CV4 7AL,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a206">
<institution>Department of Medical Informatics Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name>
<affiliation>
<nlm:aff id="a141">
<institution>Division of Medical Genetics, Department of Biomedicine, University of Basel</institution>
, 4031 Basel,
<country>Switzerland</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a207">
<institution>Faculty of Applied Sciences, Delft University of Technology</institution>
, Delft, 2628 CD,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nyberg, Lars" sort="Nyberg, Lars" uniqKey="Nyberg L" first="Lars" last="Nyberg">Lars Nyberg</name>
<affiliation>
<nlm:aff id="a22">
<institution>Department of Integrative Medical Biology and Umeå Center for Functional Brain Imaging, Umeå University</institution>
, 901 87 Umeå,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ohi, Kazutaka" sort="Ohi, Kazutaka" uniqKey="Ohi K" first="Kazutaka" last="Ohi">Kazutaka Ohi</name>
<affiliation>
<nlm:aff id="a171">
<institution>Department of Radiology, St. Olav's Hospital, Trondheim University Hospital</institution>
, Trondheim, 7030,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L." last="Olvera">Rene L. Olvera</name>
<affiliation>
<nlm:aff id="a166">
<institution>Medical and Molecular Genetics, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ophoff, Roel A" sort="Ophoff, Roel A" uniqKey="Ophoff R" first="Roel A." last="Ophoff">Roel A. Ophoff</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a85">
<institution>Center for Neurobehavioral Genetics, University of California</institution>
, Los Angeles, California 90095,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pandolfo, Massimo" sort="Pandolfo, Massimo" uniqKey="Pandolfo M" first="Massimo" last="Pandolfo">Massimo Pandolfo</name>
<affiliation>
<nlm:aff id="a155">
<institution>Neurology Division, Beaumont Hospital</institution>
, Dublin 9,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Paus, Tomas" sort="Paus, Tomas" uniqKey="Paus T" first="Tomas" last="Paus">Tomas Paus</name>
<affiliation>
<nlm:aff id="a208">
<institution>Department of Genomics, Life & Brain Center, University of Bonn</institution>
, 53127 Bonn,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a209">
<institution>Rotman Research Institute, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M6A 2E1</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a210">
<institution>Departments of Psychology and Psychiatry, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M5T 1R8</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pausova, Zdenka" sort="Pausova, Zdenka" uniqKey="Pausova Z" first="Zdenka" last="Pausova">Zdenka Pausova</name>
<affiliation>
<nlm:aff id="a39">
<institution>Hospital for Sick Children, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M5G 1X8</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a211">
<institution>Child Mind Institute</institution>
, New York, New York, 10022,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Penninx, Brenda W J H" sort="Penninx, Brenda W J H" uniqKey="Penninx B" first="Brenda W. J. H." last="Penninx">Brenda W. J. H. Penninx</name>
<affiliation>
<nlm:aff id="a100">
<institution>Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center</institution>
, 1007 MB Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pike, G Bruce" sort="Pike, G Bruce" uniqKey="Pike G" first="G. Bruce" last="Pike">G. Bruce Pike</name>
<affiliation>
<nlm:aff id="a212">
<institution>Departments of Physiology and Nutritional Sciences, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M5S 3E2</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a213">
<institution>Department of Radiology, University of Calgary</institution>
, Calgary, Alberta,
<country>Canada</country>
T2N 4N1</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Potkin, Steven G" sort="Potkin, Steven G" uniqKey="Potkin S" first="Steven G." last="Potkin">Steven G. Potkin</name>
<affiliation>
<nlm:aff id="a116">
<institution>Department of Psychiatry and Human Behavior, University of California-Irvine</institution>
, Irvine, California 92617,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<affiliation>
<nlm:aff id="a214">
<institution>Department of Clinical Neuroscience, University of Calgary</institution>
, Calgary, Alberta,
<country>Canada</country>
T2N 4N1</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Reppermund, Simone" sort="Reppermund, Simone" uniqKey="Reppermund S" first="Simone" last="Reppermund">Simone Reppermund</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a215">
<institution>Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, USA Group Health Research Institute, Group Health</institution>
, 1730 Minor Avenue/Suite 1360, Seattle, Washington 98101,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name>
<affiliation>
<nlm:aff id="a55">
<institution>Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg</institution>
, 68159 Mannheim,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Roffman, Joshua L" sort="Roffman, Joshua L" uniqKey="Roffman J" first="Joshua L." last="Roffman">Joshua L. Roffman</name>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Romanczuk Seiferth, Nina" sort="Romanczuk Seiferth, Nina" uniqKey="Romanczuk Seiferth N" first="Nina" last="Romanczuk-Seiferth">Nina Romanczuk-Seiferth</name>
<affiliation>
<nlm:aff id="a160">
<institution>Janssen Research & Development, LLC</institution>
, Titusville, New Jersey 08560,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name>
<affiliation>
<nlm:aff id="a216">
<institution>Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ryten, Mina" sort="Ryten, Mina" uniqKey="Ryten M" first="Mina" last="Ryten">Mina Ryten</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a89">
<institution>Department of Medical and Molecular Genetics, King's College London</institution>
, London SE1 9RT,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sacco, Ralph L" sort="Sacco, Ralph L" uniqKey="Sacco R" first="Ralph L." last="Sacco">Ralph L. Sacco</name>
<affiliation>
<nlm:aff id="a35">
<institution>John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a96">
<institution>Department of Neurology, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a97">
<institution>Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a217">
<institution>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center</institution>
, Torrance, California 90502,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S." last="Sachdev">Perminder S. Sachdev</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a218">
<institution>Evelyn F. McKnight Brain Institute, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Saykin, Andrew J" sort="Saykin, Andrew J" uniqKey="Saykin A" first="Andrew J." last="Saykin">Andrew J. Saykin</name>
<affiliation>
<nlm:aff id="a66">
<institution>Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a68">
<institution>Indiana Alzheimer Disease Center, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a165">
<institution>Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston</institution>
, Houston, Texas, 77030,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation>
<nlm:aff id="a6">
<institution>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz</institution>
, Auenbruggerplatz 22, 8036 Graz,
<country>Austria</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation>
<nlm:aff id="a219">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Randwick, New South Wales 2031,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name>
<affiliation>
<nlm:aff id="a189">
<institution>Department of Neurology, Mayo Clinic</institution>
, Rochester, Minnesota, 55905,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a190">
<institution>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine</institution>
, Baltimore, Maryland, 21228,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sigursson, Sigurdur" sort="Sigursson, Sigurdur" uniqKey="Sigursson S" first="Sigurdur" last="Sigursson">Sigurdur Sigursson</name>
<affiliation>
<nlm:aff id="a103">
<institution>Icelandic Heart Association</institution>
, Kopavogur, 201,
<country>Iceland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Simmons, Andrew" sort="Simmons, Andrew" uniqKey="Simmons A" first="Andrew" last="Simmons">Andrew Simmons</name>
<affiliation>
<nlm:aff id="a220">
<institution>Institute of Molecular Biology and Biochemistry, Medical University Graz</institution>
, Harrachgasse 21/III, 8010 Graz,
<country>Austria</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a221">
<institution>Department of Neuroimaging, Institute of Psychiatry, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a222">
<institution>Biomedical Research Centre for Mental Health, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sisodiya, Sanjay M" sort="Sisodiya, Sanjay M" uniqKey="Sisodiya S" first="Sanjay M." last="Sisodiya">Sanjay M. Sisodiya</name>
<affiliation>
<nlm:aff id="a64">
<institution>UCL Institute of Neurology, London, United Kingdom and Epilepsy Society</institution>
, Bucks, SL9 0RJ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Smith, Colin" sort="Smith, Colin" uniqKey="Smith C" first="Colin" last="Smith">Colin Smith</name>
<affiliation>
<nlm:aff id="a223">
<institution>Biomedical Research Unit for Dementia, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Smoller, Jordan W" sort="Smoller, Jordan W" uniqKey="Smoller J" first="Jordan W." last="Smoller">Jordan W. Smoller</name>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a70">
<institution>Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a71">
<institution>Harvard Medical School</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a72">
<institution>Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard</institution>
, Boston, Massachusetts 02141,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name>
<affiliation>
<nlm:aff id="a224">
<institution>MRC Edinburgh Brain Bank, University of Edinburgh, Academic Department of Neuropathology, Centre for Clinical Brain Sciences</institution>
, Edinburgh, EH16 4SB
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a225">
<institution>Institute of Clinical Medicine, Neurology, University of Eastern Finland</institution>
, FI-70211 Kuopio,
<country>Finland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Steen, Vidar M" sort="Steen, Vidar M" uniqKey="Steen V" first="Vidar M." last="Steen">Vidar M. Steen</name>
<affiliation>
<nlm:aff id="a52">
<institution>NORMENT—KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a53">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J." last="Stott">David J. Stott</name>
<affiliation>
<nlm:aff id="a226">
<institution>Neurocentre Neurology, Kuopio University Hospital</institution>
, FI-70211 Kuopio,
<country>Finland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sussmann, Jessika E" sort="Sussmann, Jessika E" uniqKey="Sussmann J" first="Jessika E." last="Sussmann">Jessika E. Sussmann</name>
<affiliation>
<nlm:aff id="a87">
<institution>Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh</institution>
, Edinburgh EH10 5HF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Thalamuthu, Anbupalam" sort="Thalamuthu, Anbupalam" uniqKey="Thalamuthu A" first="Anbupalam" last="Thalamuthu">Anbupalam Thalamuthu</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W." last="Toga">Arthur W. Toga</name>
<affiliation>
<nlm:aff id="a227">
<institution>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow</institution>
, Glasgow, G4 0SF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Traynor, Bryan J" sort="Traynor, Bryan J" uniqKey="Traynor B" first="Bryan J." last="Traynor">Bryan J. Traynor</name>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Troncoso, Juan" sort="Troncoso, Juan" uniqKey="Troncoso J" first="Juan" last="Troncoso">Juan Troncoso</name>
<affiliation>
<nlm:aff id="a228">
<institution>Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine of the University of Southern California</institution>
, Los Angeles, California 90033,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name>
<affiliation>
<nlm:aff id="a229">
<institution>Department of Pathology, Johns Hopkins University</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation>
<nlm:aff id="a4">
<institution>INSERM Unit U1219, University of Bordeaux</institution>
, 33076 Bordeaux,
<country>France</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a230">
<institution>3rd Department of Neurology, "G. Papanicolaou", Hospital, Aristotle University of Thessaloniki</institution>
, Thessaloniki, 57010,
<country>Greece</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation>
<nlm:aff id="a2">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a231">
<institution>Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR1219</institution>
, Bordeaux, F-33000,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hernandez, Maria C Valdes" sort="Hernandez, Maria C Valdes" uniqKey="Hernandez M" first="Maria C. Valdés" last="Hernández">Maria C. Valdés Hernández</name>
<affiliation>
<nlm:aff id="a26">
<institution>Brain Research Imaging Centre, University of Edinburgh</institution>
, Edinburgh EH4 2XU,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a28">
<institution>Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a95">
<institution>Centre for Clinical Brain Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
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</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Der Brug, Marcel" sort="Van Der Brug, Marcel" uniqKey="Van Der Brug M" first="Marcel" last="Van Der Brug">Marcel Van Der Brug</name>
<affiliation>
<nlm:aff id="a232">
<institution>Department of Internal Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
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</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name>
<affiliation>
<nlm:aff id="a3">
<institution>Department of Radiology and Nuclear Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Der Wee, Nic J A" sort="Van Der Wee, Nic J A" uniqKey="Van Der Wee N" first="Nic J. A." last="Van Der Wee">Nic J. A. Van Der Wee</name>
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<nlm:aff id="a233">
<institution>Genentech Inc.</institution>
, South San Francisco, California 94080,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Haren, Neeltje E M" sort="Van Haren, Neeltje E M" uniqKey="Van Haren N" first="Neeltje E. M." last="Van Haren">Neeltje E. M. Van Haren</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van T Ent, Dennis" sort="Van T Ent, Dennis" uniqKey="Van T Ent D" first="Dennis" last="Van T Ent">Dennis Van T Ent</name>
<affiliation>
<nlm:aff id="a48">
<institution>Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Tol, Marie Jose" sort="Van Tol, Marie Jose" uniqKey="Van Tol M" first="Marie-Jose" last="Van Tol">Marie-Jose Van Tol</name>
<affiliation>
<nlm:aff id="a234">
<institution>Department of Psychiatry and Leiden Institute for Brain and Cognition, Leiden University Medical Center</institution>
, 2333 ZA Leiden,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N." last="Vardarajan">Badri N. Vardarajan</name>
<affiliation>
<nlm:aff id="a40">
<institution>Taub Institute for Research on Alzheimer's Disease and the Aging Brain; G.H. Sergievsky Center; Department of Neurology. Columbia University Medical Center</institution>
, 639 West 1168th Street, New York, New York 10032,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name>
<affiliation>
<nlm:aff id="a235">
<institution>University of Groningen, University Medical Center Groningen, Department of Neuroscience</institution>
, 9713 AW Groningen,
<country>the Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Veltman, Dick J" sort="Veltman, Dick J" uniqKey="Veltman D" first="Dick J." last="Veltman">Dick J. Veltman</name>
<affiliation>
<nlm:aff id="a100">
<institution>Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center</institution>
, 1007 MB Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<affiliation>
<nlm:aff id="a107">
<institution>Institute for Community Medicine, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Walter, Henrik" sort="Walter, Henrik" uniqKey="Walter H" first="Henrik" last="Walter">Henrik Walter</name>
<affiliation>
<nlm:aff id="a160">
<institution>Janssen Research & Development, LLC</institution>
, Titusville, New Jersey 08560,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M." last="Wardlaw">Joanna M. Wardlaw</name>
<affiliation>
<nlm:aff id="a26">
<institution>Brain Research Imaging Centre, University of Edinburgh</institution>
, Edinburgh EH4 2XU,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a28">
<institution>Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a95">
<institution>Centre for Clinical Brain Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wassink, Thomas H" sort="Wassink, Thomas H" uniqKey="Wassink T" first="Thomas H." last="Wassink">Thomas H. Wassink</name>
<affiliation>
<nlm:aff id="a236">
<institution>Department of Internal Medicine and Geriatric Medicine, INSERM U1027, University of Toulouse</institution>
, Toulouse, 31024,
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</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Weale, Michael E" sort="Weale, Michael E" uniqKey="Weale M" first="Michael E." last="Weale">Michael E. Weale</name>
<affiliation>
<nlm:aff id="a89">
<institution>Department of Medical and Molecular Genetics, King's College London</institution>
, London SE1 9RT,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Weinberger, Daniel R" sort="Weinberger, Daniel R" uniqKey="Weinberger D" first="Daniel R." last="Weinberger">Daniel R. Weinberger</name>
<affiliation>
<nlm:aff id="a44">
<institution>Lieber Institute for Brain Development</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a237">
<institution>Department of Psychiatry, Carver College of Medicine, University of Iowa</institution>
, Iowa City, Iowa 52242,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Weiner, Michael W" sort="Weiner, Michael W" uniqKey="Weiner M" first="Michael W." last="Weiner">Michael W. Weiner</name>
<affiliation>
<nlm:aff id="a238">
<institution>Departments of Psychiatry, Neurology, Neuroscience and the Institute of Genetic Medicine, Johns Hopkins University School of Medicine</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wen, Wei" sort="Wen, Wei" uniqKey="Wen W" first="Wei" last="Wen">Wei Wen</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a218">
<institution>Evelyn F. McKnight Brain Institute, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Westman, Eric" sort="Westman, Eric" uniqKey="Westman E" first="Eric" last="Westman">Eric Westman</name>
<affiliation>
<nlm:aff id="a239">
<institution>Center for Imaging of Neurodegenerative Disease, San Francisco VA Medical Center, University of California</institution>
, San Francisco, California 94121,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="White, Tonya" sort="White, Tonya" uniqKey="White T" first="Tonya" last="White">Tonya White</name>
<affiliation>
<nlm:aff id="a3">
<institution>Department of Radiology and Nuclear Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a240">
<institution>Department of Neurobiology, Care Sciences and Society, Karolinska Institutet</institution>
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</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wong, Tien Y" sort="Wong, Tien Y" uniqKey="Wong T" first="Tien Y." last="Wong">Tien Y. Wong</name>
<affiliation>
<nlm:aff id="a14">
<institution>Academic Medicine Research Institute, Duke-NUS Graduate Medical School</institution>
, Singapore, 169857,
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</affiliation>
<affiliation>
<nlm:aff id="a15">
<institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>
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</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a139">
<institution>Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway</institution>
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</affiliation>
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<author>
<name sortKey="Wright, Clinton B" sort="Wright, Clinton B" uniqKey="Wright C" first="Clinton B." last="Wright">Clinton B. Wright</name>
<affiliation>
<nlm:aff id="a96">
<institution>Department of Neurology, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
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</affiliation>
<affiliation>
<nlm:aff id="a97">
<institution>Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
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</affiliation>
<affiliation>
<nlm:aff id="a217">
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</affiliation>
</author>
<author>
<name sortKey="Zielke, Ronald H" sort="Zielke, Ronald H" uniqKey="Zielke R" first="Ronald H." last="Zielke">Ronald H. Zielke</name>
<affiliation>
<nlm:aff id="a182">
<institution>Department of Psychiatry, Fujita Health University School of Medicine</institution>
, Toyoake 470-1192,
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</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zonderman, Alan B" sort="Zonderman, Alan B" uniqKey="Zonderman A" first="Alan B." last="Zonderman">Alan B. Zonderman</name>
<affiliation>
<nlm:aff id="a241">
<institution>Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital</institution>
, 3015 CE Rotterdam,
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</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation>
<nlm:aff id="a8">
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation>
<nlm:aff id="a2">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name>
<affiliation>
<nlm:aff id="a106">
<institution>Queensland Brain Institute, University of Queensland</institution>
, Brisbane, Queensland 4072,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a198">
<institution>Department of Radiology, Johns Hopkins University School of Medicine</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W. T." last="Longstreth">W. T. Longstreth</name>
<affiliation>
<nlm:aff id="a242">
<institution>Laboratory of Epidemiology & Population Sciences, National Institute on Aging, National Institutes of Health</institution>
, Bethesda, Maryland 20892,
<country>USA</country>
</nlm:aff>
</affiliation>
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<author>
<name sortKey="Schumann, Gunter" sort="Schumann, Gunter" uniqKey="Schumann G" first="Gunter" last="Schumann">Gunter Schumann</name>
<affiliation>
<nlm:aff id="a18">
<institution>MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London</institution>
, London SE5 8AF,
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</affiliation>
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<author>
<name sortKey="Grabe, Hans J" sort="Grabe, Hans J" uniqKey="Grabe H" first="Hans J." last="Grabe">Hans J. Grabe</name>
<affiliation>
<nlm:aff id="a63">
<institution>Department of Psychiatry, University Medicine Greifswald</institution>
, 17489 Greifswald,
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</affiliation>
</author>
<author>
<name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
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</affiliation>
<affiliation>
<nlm:aff id="a11">
<institution>Department of Psychiatry, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation>
<nlm:aff id="a243">
<institution>Departments of Neurology and Epidemiology, University of Washington</institution>
, 325 Ninth Avenue, Seattle, Washington 98104-2420,
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</affiliation>
</author>
<author>
<name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name>
<affiliation>
<nlm:aff id="a8">
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
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</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation>
<nlm:aff id="a36">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, Massachusetts,02118,
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</affiliation>
<affiliation>
<nlm:aff id="a38">
<institution>Framingham Heart Study</institution>
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<nlm:aff id="a1">
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, Los Angeles, California 90292,
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<affiliation>
<nlm:aff id="a2">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a3">
<institution>Department of Radiology and Nuclear Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a244">
<institution>Intramural Research Program, NIA, NIH</institution>
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<institution>Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California</institution>
, Los Angeles, California 90292,
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<affiliation>
<nlm:aff id="a2">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a3">
<institution>Department of Radiology and Nuclear Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
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<name sortKey="Jahanshad, Neda" sort="Jahanshad, Neda" uniqKey="Jahanshad N" first="Neda" last="Jahanshad">Neda Jahanshad</name>
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<nlm:aff id="a1">
<institution>Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California</institution>
, Los Angeles, California 90292,
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</affiliation>
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<name sortKey="Chauhan, Ganesh" sort="Chauhan, Ganesh" uniqKey="Chauhan G" first="Ganesh" last="Chauhan">Ganesh Chauhan</name>
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<nlm:aff id="a4">
<institution>INSERM Unit U1219, University of Bordeaux</institution>
, 33076 Bordeaux,
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<name sortKey="Stein, Jason L" sort="Stein, Jason L" uniqKey="Stein J" first="Jason L." last="Stein">Jason L. Stein</name>
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<nlm:aff id="a1">
<institution>Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California</institution>
, Los Angeles, California 90292,
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<nlm:aff id="a5">
<institution>Department of Genetics & UNC Neuroscience Center, University of North Carolina (UNC)</institution>
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<nlm:aff id="a6">
<institution>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz</institution>
, Auenbruggerplatz 22, 8036 Graz,
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<nlm:aff id="a7">
<institution>Institute of Medical Informatics, Statistics and Documentation, Medical University Graz</institution>
, Auenbruggerplatz 22, 8036 Graz,
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<name sortKey="Renteria, Miguel E" sort="Renteria, Miguel E" uniqKey="Renteria M" first="Miguel E." last="Renteria">Miguel E. Renteria</name>
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<nlm:aff id="a8">
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
<country>Australia</country>
</nlm:aff>
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<author>
<name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation>
<nlm:aff id="a9">
<institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>
, 1730 Minor Avenue/Suite 1360. Seattle, Washington 98101,
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<name sortKey="Arias Vasquez, Alejandro" sort="Arias Vasquez, Alejandro" uniqKey="Arias Vasquez A" first="Alejandro" last="Arias-Vasquez">Alejandro Arias-Vasquez</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a11">
<institution>Department of Psychiatry, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a12">
<institution>Department of Cognitive Neuroscience, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ikram, M Kamran" sort="Ikram, M Kamran" uniqKey="Ikram M" first="M. Kamran" last="Ikram">M. Kamran Ikram</name>
<affiliation>
<nlm:aff id="a2">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a14">
<institution>Academic Medicine Research Institute, Duke-NUS Graduate Medical School</institution>
, Singapore, 169857,
<country>Singapore</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a15">
<institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>
, Singapore, 168751,
<country>Singapore</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a16">
<institution>Memory Aging & Cognition Centre (MACC), National University Health System</institution>
, Singapore, 119228,
<country>Singapore</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a17">
<institution>Department of Pharmacology, National University of Singapore</institution>
, Singapore, 119077,
<country>Singapore</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Desrivieres, Sylvane" sort="Desrivieres, Sylvane" uniqKey="Desrivieres S" first="Sylvane" last="Desrivières">Sylvane Desrivières</name>
<affiliation>
<nlm:aff id="a18">
<institution>MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name>
<affiliation>
<nlm:aff id="a2">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a3">
<institution>Department of Radiology and Nuclear Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Abramovic, Lucija" sort="Abramovic, Lucija" uniqKey="Abramovic L" first="Lucija" last="Abramovic">Lucija Abramovic</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Alhusaini, Saud" sort="Alhusaini, Saud" uniqKey="Alhusaini S" first="Saud" last="Alhusaini">Saud Alhusaini</name>
<affiliation>
<nlm:aff id="a20">
<institution>Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University</institution>
, Montreal, Quebec,
<country>Canada</country>
H3A 2B4</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a21">
<institution>The Royal College of Surgeons in Ireland</institution>
, 123 St Stephen's Green, Dublin 2,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name>
<affiliation>
<nlm:aff id="a2">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Andersson, Micael" sort="Andersson, Micael" uniqKey="Andersson M" first="Micael" last="Andersson">Micael Andersson</name>
<affiliation>
<nlm:aff id="a22">
<institution>Department of Integrative Medical Biology and Umeå Center for Functional Brain Imaging, Umeå University</institution>
, 901 87 Umeå,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name>
<affiliation>
<nlm:aff id="a23">
<institution>Department of Biomedical Engineering, Illinois Institute of Technology</institution>
, Chicago, Illinois 60616,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a24">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, Illinois 60612,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a25">
<institution>Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center</institution>
, Chicago, Illinois 60616,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Aribisala, Benjamin S" sort="Aribisala, Benjamin S" uniqKey="Aribisala B" first="Benjamin S." last="Aribisala">Benjamin S. Aribisala</name>
<affiliation>
<nlm:aff id="a26">
<institution>Brain Research Imaging Centre, University of Edinburgh</institution>
, Edinburgh EH4 2XU,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a27">
<institution>Department of Computer Science, Lagos State University</institution>
, Lagos, P.M.B. 01 LASU,
<country>Nigeria</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a28">
<institution>Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Armstrong, Nicola J" sort="Armstrong, Nicola J" uniqKey="Armstrong N" first="Nicola J." last="Armstrong">Nicola J. Armstrong</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a30">
<institution>Mathematics and Statistics, Murdoch University</institution>
, Perth, Western Australia, 6150,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Athanasiu, Lavinia" sort="Athanasiu, Lavinia" uniqKey="Athanasiu L" first="Lavinia" last="Athanasiu">Lavinia Athanasiu</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a32">
<institution>NORMENT—KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital</institution>
, 0424 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Axelsson, Tomas" sort="Axelsson, Tomas" uniqKey="Axelsson T" first="Tomas" last="Axelsson">Tomas Axelsson</name>
<affiliation>
<nlm:aff id="a33">
<institution>Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University</institution>
, Box 1432, SE-751 44 Uppsala,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Beecham, Ashley H" sort="Beecham, Ashley H" uniqKey="Beecham A" first="Ashley H." last="Beecham">Ashley H. Beecham</name>
<affiliation>
<nlm:aff id="a34">
<institution>Dr John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a35">
<institution>John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name>
<affiliation>
<nlm:aff id="a36">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, Massachusetts,02118,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a37">
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, Massachusetts 02118
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a38">
<institution>Framingham Heart Study</institution>
, 17 Mount Wayte Avenue, Framingham, Massachusetts 01703
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bernard, Manon" sort="Bernard, Manon" uniqKey="Bernard M" first="Manon" last="Bernard">Manon Bernard</name>
<affiliation>
<nlm:aff id="a39">
<institution>Hospital for Sick Children, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M5G 1X8</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Blanton, Susan H" sort="Blanton, Susan H" uniqKey="Blanton S" first="Susan H." last="Blanton">Susan H. Blanton</name>
<affiliation>
<nlm:aff id="a34">
<institution>Dr John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a35">
<institution>John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bohlken, Marc M" sort="Bohlken, Marc M" uniqKey="Bohlken M" first="Marc M." last="Bohlken">Marc M. Bohlken</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Boks, Marco P" sort="Boks, Marco P" uniqKey="Boks M" first="Marco P." last="Boks">Marco P. Boks</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bralten, Janita" sort="Bralten, Janita" uniqKey="Bralten J" first="Janita" last="Bralten">Janita Bralten</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Brickman, Adam M" sort="Brickman, Adam M" uniqKey="Brickman A" first="Adam M." last="Brickman">Adam M. Brickman</name>
<affiliation>
<nlm:aff id="a40">
<institution>Taub Institute for Research on Alzheimer's Disease and the Aging Brain; G.H. Sergievsky Center; Department of Neurology. Columbia University Medical Center</institution>
, 639 West 1168th Street, New York, New York 10032,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Carmichael, Owen" sort="Carmichael, Owen" uniqKey="Carmichael O" first="Owen" last="Carmichael">Owen Carmichael</name>
<affiliation>
<nlm:aff id="a41">
<institution>Pennington Biomedical Research Center</institution>
, Baton Rouge, Louisiana 70808,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chakravarty, M Mallar" sort="Chakravarty, M Mallar" uniqKey="Chakravarty M" first="M. Mallar" last="Chakravarty">M. Mallar Chakravarty</name>
<affiliation>
<nlm:aff id="a42">
<institution>Cerebral Imaging Centre, Douglas Mental Health University Institute</institution>
, Montreal, Quebec, Canada H4H 1R3</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a43">
<institution>Department of Psychiatry and Biomedical Engineering, McGill University</institution>
, Montreal, Quebec,
<country>Canada</country>
H3A 2B4</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chen, Qiang" sort="Chen, Qiang" uniqKey="Chen Q" first="Qiang" last="Chen">Qiang Chen</name>
<affiliation>
<nlm:aff id="a44">
<institution>Lieber Institute for Brain Development</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ching, Christopher R K" sort="Ching, Christopher R K" uniqKey="Ching C" first="Christopher R. K." last="Ching">Christopher R. K. Ching</name>
<affiliation>
<nlm:aff id="a1">
<institution>Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California</institution>
, Los Angeles, California 90292,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a45">
<institution>Interdepartmental Neuroscience Graduate Program, UCLA School of Medicine</institution>
, Los Angeles, California 90095,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name>
<affiliation>
<nlm:aff id="a36">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, Massachusetts,02118,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a38">
<institution>Framingham Heart Study</institution>
, 17 Mount Wayte Avenue, Framingham, Massachusetts 01703
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a46">
<institution>Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167—RID-AGE—Risk factors and molecular determinants of aging-related diseases</institution>
, F-59000 Lille,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cuellar Partida, Gabriel" sort="Cuellar Partida, Gabriel" uniqKey="Cuellar Partida G" first="Gabriel" last="Cuellar-Partida">Gabriel Cuellar-Partida</name>
<affiliation>
<nlm:aff id="a8">
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name>
<affiliation>
<nlm:aff id="a47">
<institution>IMN UMR5293, GIN, CNRS, CEA, University of Bordeaux</institution>
, 146 rue Léo Saignat, 33076 Bordeaux,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name>
<affiliation>
<nlm:aff id="a48">
<institution>Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Doan, Nhat Trung" sort="Doan, Nhat Trung" uniqKey="Doan N" first="Nhat Trung" last="Doan">Nhat Trung Doan</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ehrlich, Stefan" sort="Ehrlich, Stefan" uniqKey="Ehrlich S" first="Stefan" last="Ehrlich">Stefan Ehrlich</name>
<affiliation>
<nlm:aff id="a49">
<institution>Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden</institution>
, 01307 Dresden,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a51">
<institution>Martinos Center for Biomedical Imaging, Massachusetts General Hospital</institution>
, Charlestown, Massachusetts 02129,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Giddaluru, Sudheer" sort="Giddaluru, Sudheer" uniqKey="Giddaluru S" first="Sudheer" last="Giddaluru">Sudheer Giddaluru</name>
<affiliation>
<nlm:aff id="a52">
<institution>NORMENT—KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a53">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Goldman, Aaron L" sort="Goldman, Aaron L" uniqKey="Goldman A" first="Aaron L." last="Goldman">Aaron L. Goldman</name>
<affiliation>
<nlm:aff id="a44">
<institution>Lieber Institute for Brain Development</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gottesman, Rebecca F" sort="Gottesman, Rebecca F" uniqKey="Gottesman R" first="Rebecca F." last="Gottesman">Rebecca F. Gottesman</name>
<affiliation>
<nlm:aff id="a54">
<institution>Department of Neurology, Johns Hopkins University School of Medicine</institution>
, Baltimore, Maryland 21287,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Grimm, Oliver" sort="Grimm, Oliver" uniqKey="Grimm O" first="Oliver" last="Grimm">Oliver Grimm</name>
<affiliation>
<nlm:aff id="a55">
<institution>Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg</institution>
, 68159 Mannheim,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Griswold, Michael E" sort="Griswold, Michael E" uniqKey="Griswold M" first="Michael E." last="Griswold">Michael E. Griswold</name>
<affiliation>
<nlm:aff id="a56">
<institution>Department of Data Science, University of Mississippi Medical Center</institution>
, Jackson, Mississippi, 39216,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Guadalupe, Tulio" sort="Guadalupe, Tulio" uniqKey="Guadalupe T" first="Tulio" last="Guadalupe">Tulio Guadalupe</name>
<affiliation>
<nlm:aff id="a57">
<institution>Language and Genetics Department, Max Planck Institute for Psycholinguistics</institution>
, 6525 XD Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a58">
<institution>International Max Planck Research School for Language Sciences</institution>
, 6525 XD Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gutman, Boris A" sort="Gutman, Boris A" uniqKey="Gutman B" first="Boris A." last="Gutman">Boris A. Gutman</name>
<affiliation>
<nlm:aff id="a1">
<institution>Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California</institution>
, Los Angeles, California 90292,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hass, Johanna" sort="Hass, Johanna" uniqKey="Hass J" first="Johanna" last="Hass">Johanna Hass</name>
<affiliation>
<nlm:aff id="a59">
<institution>Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden</institution>
, 01307 Dresden,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Haukvik, Unn K" sort="Haukvik, Unn K" uniqKey="Haukvik U" first="Unn K." last="Haukvik">Unn K. Haukvik</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a60">
<institution>Department of Research and Development, Diakonhjemmet Hospital</institution>
, 0319 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hoehn, David" sort="Hoehn, David" uniqKey="Hoehn D" first="David" last="Hoehn">David Hoehn</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Holmes, Avram J" sort="Holmes, Avram J" uniqKey="Holmes A" first="Avram J." last="Holmes">Avram J. Holmes</name>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a62">
<institution>Department of Psychology, Yale University</institution>
, New Haven, Connecticut 06520,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hoogman, Martine" sort="Hoogman, Martine" uniqKey="Hoogman M" first="Martine" last="Hoogman">Martine Hoogman</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Janowitz, Deborah" sort="Janowitz, Deborah" uniqKey="Janowitz D" first="Deborah" last="Janowitz">Deborah Janowitz</name>
<affiliation>
<nlm:aff id="a63">
<institution>Department of Psychiatry, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Jia, Tianye" sort="Jia, Tianye" uniqKey="Jia T" first="Tianye" last="Jia">Tianye Jia</name>
<affiliation>
<nlm:aff id="a18">
<institution>MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="J Rgensen, Kjetil N" sort="J Rgensen, Kjetil N" uniqKey="J Rgensen K" first="Kjetil N." last="J Rgensen">Kjetil N. J Rgensen</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a60">
<institution>Department of Research and Development, Diakonhjemmet Hospital</institution>
, 0319 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Karbalai, Nazanin" sort="Karbalai, Nazanin" uniqKey="Karbalai N" first="Nazanin" last="Karbalai">Nazanin Karbalai</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kasperaviciute, Dalia" sort="Kasperaviciute, Dalia" uniqKey="Kasperaviciute D" first="Dalia" last="Kasperaviciute">Dalia Kasperaviciute</name>
<affiliation>
<nlm:aff id="a64">
<institution>UCL Institute of Neurology, London, United Kingdom and Epilepsy Society</institution>
, Bucks, SL9 0RJ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a65">
<institution>Department of Medicine, Imperial College London</institution>
, London SW7 2AZ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kim, Sungeun" sort="Kim, Sungeun" uniqKey="Kim S" first="Sungeun" last="Kim">Sungeun Kim</name>
<affiliation>
<nlm:aff id="a66">
<institution>Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a67">
<institution>Center for Computational Biology and Bioinformatics, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a68">
<institution>Indiana Alzheimer Disease Center, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Klein, Marieke" sort="Klein, Marieke" uniqKey="Klein M" first="Marieke" last="Klein">Marieke Klein</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kraemer, Bernd" sort="Kraemer, Bernd" uniqKey="Kraemer B" first="Bernd" last="Kraemer">Bernd Kraemer</name>
<affiliation>
<nlm:aff id="a69">
<institution>Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University</institution>
, Heidelberg, 69120,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lee, Phil H" sort="Lee, Phil H" uniqKey="Lee P" first="Phil H." last="Lee">Phil H. Lee</name>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a70">
<institution>Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a71">
<institution>Harvard Medical School</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a72">
<institution>Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard</institution>
, Boston, Massachusetts 02141,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a73">
<institution>Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School</institution>
, Lexington, Massachusetts, 02421,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Liewald, David C M" sort="Liewald, David C M" uniqKey="Liewald D" first="David C. M." last="Liewald">David C. M. Liewald</name>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Luciano, Michelle" sort="Luciano, Michelle" uniqKey="Luciano M" first="Michelle" last="Luciano">Michelle Luciano</name>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Macare, Christine" sort="Macare, Christine" uniqKey="Macare C" first="Christine" last="Macare">Christine Macare</name>
<affiliation>
<nlm:aff id="a18">
<institution>MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Marquand, Andre F" sort="Marquand, Andre F" uniqKey="Marquand A" first="Andre F." last="Marquand">Andre F. Marquand</name>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a75">
<institution>Donders Centre for Cognitive Neuroimaging, Radboud University</institution>
, Nijmegen, 6525 EN,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Matarin, Mar" sort="Matarin, Mar" uniqKey="Matarin M" first="Mar" last="Matarin">Mar Matarin</name>
<affiliation>
<nlm:aff id="a64">
<institution>UCL Institute of Neurology, London, United Kingdom and Epilepsy Society</institution>
, Bucks, SL9 0RJ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mather, Karen A" sort="Mather, Karen A" uniqKey="Mather K" first="Karen A." last="Mather">Karen A. Mather</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name>
<affiliation>
<nlm:aff id="a77">
<institution>Department of Biomedicine, Aarhus University</institution>
, DK-8000 Aarhus,
<country>Denmark</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a78">
<institution>The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</institution>
, DK-8000 Aarhus and Copenhagen,
<country>Denmark</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a79">
<institution>Center for integrated Sequencing, iSEQ, Aarhus University</institution>
, DK-8000 Aarhus,
<country>Denmark</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mckay, David R" sort="Mckay, David R" uniqKey="Mckay D" first="David R." last="Mckay">David R. Mckay</name>
<affiliation>
<nlm:aff id="a80">
<institution>Department of Psychiatry, Yale University</institution>
, New Haven, Connecticut 06511,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a81">
<institution>Olin Neuropsychiatric Research Center</institution>
, Hartford, Connecticut 06114,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Milaneschi, Yuri" sort="Milaneschi, Yuri" uniqKey="Milaneschi Y" first="Yuri" last="Milaneschi">Yuri Milaneschi</name>
<affiliation>
<nlm:aff id="a82">
<institution>Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest</institution>
, 1081 HL Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mu Oz Maniega, Susana" sort="Mu Oz Maniega, Susana" uniqKey="Mu Oz Maniega S" first="Susana" last="Mu Oz Maniega">Susana Mu Oz Maniega</name>
<affiliation>
<nlm:aff id="a26">
<institution>Brain Research Imaging Centre, University of Edinburgh</institution>
, Edinburgh EH4 2XU,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a28">
<institution>Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nho, Kwangsik" sort="Nho, Kwangsik" uniqKey="Nho K" first="Kwangsik" last="Nho">Kwangsik Nho</name>
<affiliation>
<nlm:aff id="a66">
<institution>Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a67">
<institution>Center for Computational Biology and Bioinformatics, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a68">
<institution>Indiana Alzheimer Disease Center, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nugent, Allison C" sort="Nugent, Allison C" uniqKey="Nugent A" first="Allison C." last="Nugent">Allison C. Nugent</name>
<affiliation>
<nlm:aff id="a83">
<institution>Human Genetics Branch, National Institute of Mental Health Intramural Research Program</institution>
, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nyquist, Paul" sort="Nyquist, Paul" uniqKey="Nyquist P" first="Paul" last="Nyquist">Paul Nyquist</name>
<affiliation>
<nlm:aff id="a84">
<institution>Department of Neurology, Department of Anesthesia/Critical Care Medicine, Department of Neurosurgery, Johns Hopkins</institution>
, USA600 N. Wolfe St, Baltimore, Maryland 21287,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Loohuis, Loes M Olde" sort="Loohuis, Loes M Olde" uniqKey="Loohuis L" first="Loes M. Olde" last="Loohuis">Loes M. Olde Loohuis</name>
<affiliation>
<nlm:aff id="a85">
<institution>Center for Neurobehavioral Genetics, University of California</institution>
, Los Angeles, California 90095,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Oosterlaan, Jaap" sort="Oosterlaan, Jaap" uniqKey="Oosterlaan J" first="Jaap" last="Oosterlaan">Jaap Oosterlaan</name>
<affiliation>
<nlm:aff id="a86">
<institution>Department of Clinical Neuropsychology, VU University Amsterdam</institution>
, Amsterdam, 1081 HV,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Papmeyer, Martina" sort="Papmeyer, Martina" uniqKey="Papmeyer M" first="Martina" last="Papmeyer">Martina Papmeyer</name>
<affiliation>
<nlm:aff id="a87">
<institution>Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh</institution>
, Edinburgh EH10 5HF,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a88">
<institution>Division of Systems Neuroscience of Psychopathology, Translational Research Center, University Hospital of Psychiatry, University of Bern</institution>
, Bern, 3060,
<country>Switzerland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pirpamer, Lukas" sort="Pirpamer, Lukas" uniqKey="Pirpamer L" first="Lukas" last="Pirpamer">Lukas Pirpamer</name>
<affiliation>
<nlm:aff id="a6">
<institution>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz</institution>
, Auenbruggerplatz 22, 8036 Graz,
<country>Austria</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Putz, Benno" sort="Putz, Benno" uniqKey="Putz B" first="Benno" last="Pütz">Benno Pütz</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a89">
<institution>Department of Medical and Molecular Genetics, King's College London</institution>
, London SE1 9RT,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a90">
<institution>The Jenner Institute Laboratories, University of Oxford</institution>
, Oxford OX3 7DQ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Richards, Jennifer S" sort="Richards, Jennifer S" uniqKey="Richards J" first="Jennifer S." last="Richards">Jennifer S. Richards</name>
<affiliation>
<nlm:aff id="a12">
<institution>Department of Cognitive Neuroscience, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a91">
<institution>Karakter Child and Adolescent Psychiatry University Center</institution>
, Nijmegen, 6525 GC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Risacher, Shannon L" sort="Risacher, Shannon L" uniqKey="Risacher S" first="Shannon L." last="Risacher">Shannon L. Risacher</name>
<affiliation>
<nlm:aff id="a66">
<institution>Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a68">
<institution>Indiana Alzheimer Disease Center, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Roiz Santia Ez, Roberto" sort="Roiz Santia Ez, Roberto" uniqKey="Roiz Santia Ez R" first="Roberto" last="Roiz-Santia Ez">Roberto Roiz-Santia Ez</name>
<affiliation>
<nlm:aff id="a92">
<institution>Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL</institution>
, 39008 Santander,
<country>Spain</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a93">
<institution>CIBERSAM (Centro Investigación Biomédica en Red Salud Mental)</institution>
, Santander, 39011,
<country>Spain</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rommelse, Nanda" sort="Rommelse, Nanda" uniqKey="Rommelse N" first="Nanda" last="Rommelse">Nanda Rommelse</name>
<affiliation>
<nlm:aff id="a11">
<institution>Department of Psychiatry, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a91">
<institution>Karakter Child and Adolescent Psychiatry University Center</institution>
, Nijmegen, 6525 GC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ropele, Stefan" sort="Ropele, Stefan" uniqKey="Ropele S" first="Stefan" last="Ropele">Stefan Ropele</name>
<affiliation>
<nlm:aff id="a6">
<institution>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz</institution>
, Auenbruggerplatz 22, 8036 Graz,
<country>Austria</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rose, Emma J" sort="Rose, Emma J" uniqKey="Rose E" first="Emma J." last="Rose">Emma J. Rose</name>
<affiliation>
<nlm:aff id="a94">
<institution>Psychosis Research Group, Department of Psychiatry & Trinity Translational Medicine Institute, Trinity College</institution>
, Dublin, Dublin 2,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Royle, Natalie A" sort="Royle, Natalie A" uniqKey="Royle N" first="Natalie A." last="Royle">Natalie A. Royle</name>
<affiliation>
<nlm:aff id="a26">
<institution>Brain Research Imaging Centre, University of Edinburgh</institution>
, Edinburgh EH4 2XU,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a28">
<institution>Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a95">
<institution>Centre for Clinical Brain Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rundek, Tatjana" sort="Rundek, Tatjana" uniqKey="Rundek T" first="Tatjana" last="Rundek">Tatjana Rundek</name>
<affiliation>
<nlm:aff id="a96">
<institution>Department of Neurology, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a97">
<institution>Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="S Mann, Philipp G" sort="S Mann, Philipp G" uniqKey="S Mann P" first="Philipp G." last="S Mann">Philipp G. S Mann</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Saremi, Arvin" sort="Saremi, Arvin" uniqKey="Saremi A" first="Arvin" last="Saremi">Arvin Saremi</name>
<affiliation>
<nlm:aff id="a1">
<institution>Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California</institution>
, Los Angeles, California 90292,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Satizabal, Claudia L" sort="Satizabal, Claudia L" uniqKey="Satizabal C" first="Claudia L." last="Satizabal">Claudia L. Satizabal</name>
<affiliation>
<nlm:aff id="a36">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, Massachusetts,02118,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a38">
<institution>Framingham Heart Study</institution>
, 17 Mount Wayte Avenue, Framingham, Massachusetts 01703
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Schmaal, Lianne" sort="Schmaal, Lianne" uniqKey="Schmaal L" first="Lianne" last="Schmaal">Lianne Schmaal</name>
<affiliation>
<nlm:aff id="a98">
<institution>Orygen, The National Centre of Excellence in Youth Mental Health</institution>
, Melbourne, Victoria, 3502,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a99">
<institution>Centre for Youth Mental Health, The University of Melbourne</institution>
, Melbourne, Victoria, 3502,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a100">
<institution>Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center</institution>
, 1007 MB Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Schork, Andrew J" sort="Schork, Andrew J" uniqKey="Schork A" first="Andrew J." last="Schork">Andrew J. Schork</name>
<affiliation>
<nlm:aff id="a101">
<institution>Multimodal Imaging Laboratory, Department of Neurosciences, University of California</institution>
, San Diego, California 92093,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a102">
<institution>Department of Cognitive Sciences, University of California</institution>
, San Diego, California 92161,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Shen, Li" sort="Shen, Li" uniqKey="Shen L" first="Li" last="Shen">Li Shen</name>
<affiliation>
<nlm:aff id="a66">
<institution>Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a67">
<institution>Center for Computational Biology and Bioinformatics, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a68">
<institution>Indiana Alzheimer Disease Center, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Shin, Jean" sort="Shin, Jean" uniqKey="Shin J" first="Jean" last="Shin">Jean Shin</name>
<affiliation>
<nlm:aff id="a39">
<institution>Hospital for Sick Children, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M5G 1X8</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Shumskaya, Elena" sort="Shumskaya, Elena" uniqKey="Shumskaya E" first="Elena" last="Shumskaya">Elena Shumskaya</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a75">
<institution>Donders Centre for Cognitive Neuroimaging, Radboud University</institution>
, Nijmegen, 6525 EN,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
<affiliation>
<nlm:aff id="a103">
<institution>Icelandic Heart Association</institution>
, Kopavogur, 201,
<country>Iceland</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a104">
<institution>Faculty of Medicine, University of Iceland</institution>
, Reykjavik, 101,
<country>Iceland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sprooten, Emma" sort="Sprooten, Emma" uniqKey="Sprooten E" first="Emma" last="Sprooten">Emma Sprooten</name>
<affiliation>
<nlm:aff id="a80">
<institution>Department of Psychiatry, Yale University</institution>
, New Haven, Connecticut 06511,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a81">
<institution>Olin Neuropsychiatric Research Center</institution>
, Hartford, Connecticut 06114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a105">
<institution>Department of Psychiatry, Icahn School of Medicine at Mount Sinai</institution>
, New York, New York, 10029,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Strike, Lachlan T" sort="Strike, Lachlan T" uniqKey="Strike L" first="Lachlan T." last="Strike">Lachlan T. Strike</name>
<affiliation>
<nlm:aff id="a8">
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a106">
<institution>Queensland Brain Institute, University of Queensland</institution>
, Brisbane, Queensland 4072,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name>
<affiliation>
<nlm:aff id="a107">
<institution>Institute for Community Medicine, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Tordesillas Gutierrez, Diana" sort="Tordesillas Gutierrez, Diana" uniqKey="Tordesillas Gutierrez D" first="Diana" last="Tordesillas-Gutierrez">Diana Tordesillas-Gutierrez</name>
<affiliation>
<nlm:aff id="a93">
<institution>CIBERSAM (Centro Investigación Biomédica en Red Salud Mental)</institution>
, Santander, 39011,
<country>Spain</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a108">
<institution>Neuroimaging Unit, Technological Facilities. Valdecilla Biomedical Research Institute IDIVAL</institution>
, Santander, Cantabria, 39011,
<country>Spain</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Toro, Roberto" sort="Toro, Roberto" uniqKey="Toro R" first="Roberto" last="Toro">Roberto Toro</name>
<affiliation>
<nlm:aff id="a109">
<institution>Institut Pasteur</institution>
, 75015 Paris,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Trabzuni, Daniah" sort="Trabzuni, Daniah" uniqKey="Trabzuni D" first="Daniah" last="Trabzuni">Daniah Trabzuni</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a110">
<institution>Department of Genetics, King Faisal Specialist Hospital and Research Centre</institution>
, Riyadh 11211,
<country>Saudi Arabia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name>
<affiliation>
<nlm:aff id="a111">
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden, 2300RC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Vaidya, Dhananjay" sort="Vaidya, Dhananjay" uniqKey="Vaidya D" first="Dhananjay" last="Vaidya">Dhananjay Vaidya</name>
<affiliation>
<nlm:aff id="a112">
<institution>GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine</institution>
, 1830 E Monument St Suite 8028, Baltimore, Maryland 21287,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Der Grond, Jeroen" sort="Van Der Grond, Jeroen" uniqKey="Van Der Grond J" first="Jeroen" last="Van Der Grond">Jeroen Van Der Grond</name>
<affiliation>
<nlm:aff id="a113">
<institution>Department of Radiology, Leiden University Medical Center</institution>
, Leiden, 2300RC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Der Lee, Sven J" sort="Van Der Lee, Sven J" uniqKey="Van Der Lee S" first="Sven J." last="Van Der Lee">Sven J. Van Der Lee</name>
<affiliation>
<nlm:aff id="a2">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Der Meer, Dennis" sort="Van Der Meer, Dennis" uniqKey="Van Der Meer D" first="Dennis" last="Van Der Meer">Dennis Van Der Meer</name>
<affiliation>
<nlm:aff id="a114">
<institution>Department of Psychiatry, University of Groningen, University Medical Center Groningen</institution>
, Groningen, 9700RB,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Donkelaar, Marjolein M J" sort="Van Donkelaar, Marjolein M J" uniqKey="Van Donkelaar M" first="Marjolein M. J." last="Van Donkelaar">Marjolein M. J. Van Donkelaar</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Eijk, Kristel R" sort="Van Eijk, Kristel R" uniqKey="Van Eijk K" first="Kristel R." last="Van Eijk">Kristel R. Van Eijk</name>
<affiliation>
<nlm:aff id="a115">
<institution>Brain Center Rudolf Magnus, Human Neurogenetics Unit, UMC Utrecht</institution>
, 3584 CG Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Erp, Theo G M" sort="Van Erp, Theo G M" uniqKey="Van Erp T" first="Theo G. M." last="Van Erp">Theo G. M. Van Erp</name>
<affiliation>
<nlm:aff id="a116">
<institution>Department of Psychiatry and Human Behavior, University of California-Irvine</institution>
, Irvine, California 92617,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Rooij, Daan" sort="Van Rooij, Daan" uniqKey="Van Rooij D" first="Daan" last="Van Rooij">Daan Van Rooij</name>
<affiliation>
<nlm:aff id="a12">
<institution>Department of Cognitive Neuroscience, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a114">
<institution>Department of Psychiatry, University of Groningen, University Medical Center Groningen</institution>
, Groningen, 9700RB,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Walton, Esther" sort="Walton, Esther" uniqKey="Walton E" first="Esther" last="Walton">Esther Walton</name>
<affiliation>
<nlm:aff id="a49">
<institution>Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden</institution>
, 01307 Dresden,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a117">
<institution>Department of Psychology, Georgia State University</institution>
, Atlanta, Georgia 30302,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Westlye, Lars T" sort="Westlye, Lars T" uniqKey="Westlye L" first="Lars T." last="Westlye">Lars T. Westlye</name>
<affiliation>
<nlm:aff id="a32">
<institution>NORMENT—KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital</institution>
, 0424 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a117">
<institution>Department of Psychology, Georgia State University</institution>
, Atlanta, Georgia 30302,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Whelan, Christopher D" sort="Whelan, Christopher D" uniqKey="Whelan C" first="Christopher D." last="Whelan">Christopher D. Whelan</name>
<affiliation>
<nlm:aff id="a1">
<institution>Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California</institution>
, Los Angeles, California 90292,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a21">
<institution>The Royal College of Surgeons in Ireland</institution>
, 123 St Stephen's Green, Dublin 2,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Windham, Beverly G" sort="Windham, Beverly G" uniqKey="Windham B" first="Beverly G." last="Windham">Beverly G. Windham</name>
<affiliation>
<nlm:aff id="a118">
<institution>NORMENT—KG Jebsen Centre, Department of Psychology, University of Oslo</institution>
, 0317 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Winkler, Anderson M" sort="Winkler, Anderson M" uniqKey="Winkler A" first="Anderson M." last="Winkler">Anderson M. Winkler</name>
<affiliation>
<nlm:aff id="a80">
<institution>Department of Psychiatry, Yale University</institution>
, New Haven, Connecticut 06511,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a119">
<institution>Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, Mississippi, 39216,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wittfeld, Katharina" sort="Wittfeld, Katharina" uniqKey="Wittfeld K" first="Katharina" last="Wittfeld">Katharina Wittfeld</name>
<affiliation>
<nlm:aff id="a63">
<institution>Department of Psychiatry, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a120">
<institution>FMRIB Centre, University of Oxford</institution>
, Oxford OX3 9DU,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Woldehawariat, Girma" sort="Woldehawariat, Girma" uniqKey="Woldehawariat G" first="Girma" last="Woldehawariat">Girma Woldehawariat</name>
<affiliation>
<nlm:aff id="a83">
<institution>Human Genetics Branch, National Institute of Mental Health Intramural Research Program</institution>
, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wolf, Christiane" sort="Wolf, Christiane" uniqKey="Wolf C" first="Christiane" last="Wolf">Christiane Wolf</name>
<affiliation>
<nlm:aff id="a121">
<institution>German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald</institution>
, 17487 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wolfers, Thomas" sort="Wolfers, Thomas" uniqKey="Wolfers T" first="Thomas" last="Wolfers">Thomas Wolfers</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Yanek, Lisa R" sort="Yanek, Lisa R" uniqKey="Yanek L" first="Lisa R." last="Yanek">Lisa R. Yanek</name>
<affiliation>
<nlm:aff id="a112">
<institution>GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine</institution>
, 1830 E Monument St Suite 8028, Baltimore, Maryland 21287,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Yang, Jingyun" sort="Yang, Jingyun" uniqKey="Yang J" first="Jingyun" last="Yang">Jingyun Yang</name>
<affiliation>
<nlm:aff id="a24">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, Illinois 60612,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a122">
<institution>University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy</institution>
, Wuerzburg, 97080,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name>
<affiliation>
<nlm:aff id="a123">
<institution>Department of Neurological Sciences, Rush University Medical Center</institution>
, Chicago, Illinois 60612,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zwiers, Marcel P" sort="Zwiers, Marcel P" uniqKey="Zwiers M" first="Marcel P." last="Zwiers">Marcel P. Zwiers</name>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a75">
<institution>Donders Centre for Cognitive Neuroimaging, Radboud University</institution>
, Nijmegen, 6525 EN,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Agartz, Ingrid" sort="Agartz, Ingrid" uniqKey="Agartz I" first="Ingrid" last="Agartz">Ingrid Agartz</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a60">
<institution>Department of Research and Development, Diakonhjemmet Hospital</institution>
, 0319 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a124">
<institution>Biospective Inc, Montreal, Quebec, Canada</institution>
, 6100 Avenue Royalmount, Montréal, Québec,
<country>Canada</country>
H4P 2R2</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Almasy, Laura" sort="Almasy, Laura" uniqKey="Almasy L" first="Laura" last="Almasy">Laura Almasy</name>
<affiliation>
<nlm:aff id="a125">
<institution>Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet</institution>
, SE-171 77 Stockholm,
<country>Sweden</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a126">
<institution>South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine</institution>
, Brownsville/Edinburg/San Antonio, Texas, 78250,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a127">
<institution>Department of Genetics, Perelman School of Medicine, University of Pennsylvania</institution>
, Philadelphia, Pennsylvania 19104,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name>
<affiliation>
<nlm:aff id="a128">
<institution>Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia</institution>
, Philadelphia, Pennsylvania 29104,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a129">
<institution>National Ageing Research Institute, Royal Melbourne Hospital</institution>
, Melbourne, Victoria 3052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation>
<nlm:aff id="a46">
<institution>Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167—RID-AGE—Risk factors and molecular determinants of aging-related diseases</institution>
, F-59000 Lille,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Andreassen, Ole A" sort="Andreassen, Ole A" uniqKey="Andreassen O" first="Ole A." last="Andreassen">Ole A. Andreassen</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a32">
<institution>NORMENT—KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital</institution>
, 0424 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Arepalli, Sampath" sort="Arepalli, Sampath" uniqKey="Arepalli S" first="Sampath" last="Arepalli">Sampath Arepalli</name>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Assareh, Amelia A" sort="Assareh, Amelia A" uniqKey="Assareh A" first="Amelia A." last="Assareh">Amelia A. Assareh</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Barral, Sandra" sort="Barral, Sandra" uniqKey="Barral S" first="Sandra" last="Barral">Sandra Barral</name>
<affiliation>
<nlm:aff id="a40">
<institution>Taub Institute for Research on Alzheimer's Disease and the Aging Brain; G.H. Sergievsky Center; Department of Neurology. Columbia University Medical Center</institution>
, 639 West 1168th Street, New York, New York 10032,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name>
<affiliation>
<nlm:aff id="a26">
<institution>Brain Research Imaging Centre, University of Edinburgh</institution>
, Edinburgh EH4 2XU,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a28">
<institution>Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a95">
<institution>Centre for Clinical Brain Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Becker, Diane M" sort="Becker, Diane M" uniqKey="Becker D" first="Diane M." last="Becker">Diane M. Becker</name>
<affiliation>
<nlm:aff id="a112">
<institution>GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine</institution>
, 1830 E Monument St Suite 8028, Baltimore, Maryland 21287,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T." last="Becker">James T. Becker</name>
<affiliation>
<nlm:aff id="a131">
<institution>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health</institution>
, Bethesda, Maryland 20892,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<affiliation>
<nlm:aff id="a24">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, Illinois 60612,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a122">
<institution>University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy</institution>
, Wuerzburg, 97080,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name>
<affiliation>
<nlm:aff id="a125">
<institution>Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet</institution>
, SE-171 77 Stockholm,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Bokhoven, Hans" sort="Van Bokhoven, Hans" uniqKey="Van Bokhoven H" first="Hans" last="Van Bokhoven">Hans Van Bokhoven</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name>
<affiliation>
<nlm:aff id="a48">
<institution>Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Brodaty, Henry" sort="Brodaty, Henry" uniqKey="Brodaty H" first="Henry" last="Brodaty">Henry Brodaty</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a132">
<institution>Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh</institution>
, 3501 Forbes Ave., Suite 830, Pittsburgh, Pennsylvania 15213,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Brouwer, Rachel M" sort="Brouwer, Rachel M" uniqKey="Brouwer R" first="Rachel M." last="Brouwer">Rachel M. Brouwer</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Brunner, Han G" sort="Brunner, Han G" uniqKey="Brunner H" first="Han G." last="Brunner">Han G. Brunner</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a133">
<institution>Dementia Collaborative Research Centre—Assessment and Better Care, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Buckner, Randy L" sort="Buckner, Randy L" uniqKey="Buckner R" first="Randy L." last="Buckner">Randy L. Buckner</name>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a134">
<institution>Department of Clinical Genetics and GROW School for Oncology and Developmental Biology, Maastricht University Medical Center</institution>
, 6200 MD Maastricht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Buitelaar, Jan K" sort="Buitelaar, Jan K" uniqKey="Buitelaar J" first="Jan K." last="Buitelaar">Jan K. Buitelaar</name>
<affiliation>
<nlm:aff id="a12">
<institution>Department of Cognitive Neuroscience, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a91">
<institution>Karakter Child and Adolescent Psychiatry University Center</institution>
, Nijmegen, 6525 GC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bulayeva, Kazima B" sort="Bulayeva, Kazima B" uniqKey="Bulayeva K" first="Kazima B." last="Bulayeva">Kazima B. Bulayeva</name>
<affiliation>
<nlm:aff id="a135">
<institution>Department of Psychology, Center for Brain Science, Harvard University</institution>
, Cambridge, Massachusetts 02138,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cahn, Wiepke" sort="Cahn, Wiepke" uniqKey="Cahn W" first="Wiepke" last="Cahn">Wiepke Cahn</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Calhoun, Vince D" sort="Calhoun, Vince D" uniqKey="Calhoun V" first="Vince D." last="Calhoun">Vince D. Calhoun</name>
<affiliation>
<nlm:aff id="a136">
<institution>Department of Evolution and Genetics, Dagestan State University</institution>
, Makhachkala 367000, Dagestan,
<country>Russia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a137">
<institution>The Mind Research Network & LBERI</institution>
, Albuquerque, New Mexico 87106,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cannon, Dara M" sort="Cannon, Dara M" uniqKey="Cannon D" first="Dara M." last="Cannon">Dara M. Cannon</name>
<affiliation>
<nlm:aff id="a83">
<institution>Human Genetics Branch, National Institute of Mental Health Intramural Research Program</institution>
, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a138">
<institution>Department of ECE, University of New Mexico</institution>
, Albuquerque, New Mexico 87131,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cavalleri, Gianpiero L" sort="Cavalleri, Gianpiero L" uniqKey="Cavalleri G" first="Gianpiero L." last="Cavalleri">Gianpiero L. Cavalleri</name>
<affiliation>
<nlm:aff id="a21">
<institution>The Royal College of Surgeons in Ireland</institution>
, 123 St Stephen's Green, Dublin 2,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name>
<affiliation>
<nlm:aff id="a14">
<institution>Academic Medicine Research Institute, Duke-NUS Graduate Medical School</institution>
, Singapore, 169857,
<country>Singapore</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a15">
<institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>
, Singapore, 168751,
<country>Singapore</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a139">
<institution>Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway</institution>
, H91 TK33 Galway,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name>
<affiliation>
<nlm:aff id="a140">
<institution>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</institution>
, Singapore, 119077,
<country>Singapore</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a141">
<institution>Division of Medical Genetics, Department of Biomedicine, University of Basel</institution>
, 4031 Basel,
<country>Switzerland</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a142">
<institution>Institute of Human Genetics, University of Bonn</institution>
, 53127 Bonn,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cookson, Mark R" sort="Cookson, Mark R" uniqKey="Cookson M" first="Mark R." last="Cookson">Mark R. Cookson</name>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Corvin, Aiden" sort="Corvin, Aiden" uniqKey="Corvin A" first="Aiden" last="Corvin">Aiden Corvin</name>
<affiliation>
<nlm:aff id="a94">
<institution>Psychosis Research Group, Department of Psychiatry & Trinity Translational Medicine Institute, Trinity College</institution>
, Dublin, Dublin 2,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Crespo Facorro, Benedicto" sort="Crespo Facorro, Benedicto" uniqKey="Crespo Facorro B" first="Benedicto" last="Crespo-Facorro">Benedicto Crespo-Facorro</name>
<affiliation>
<nlm:aff id="a92">
<institution>Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL</institution>
, 39008 Santander,
<country>Spain</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a93">
<institution>CIBERSAM (Centro Investigación Biomédica en Red Salud Mental)</institution>
, Santander, 39011,
<country>Spain</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Curran, Joanne E" sort="Curran, Joanne E" uniqKey="Curran J" first="Joanne E." last="Curran">Joanne E. Curran</name>
<affiliation>
<nlm:aff id="a125">
<institution>Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet</institution>
, SE-171 77 Stockholm,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Czisch, Michael" sort="Czisch, Michael" uniqKey="Czisch M" first="Michael" last="Czisch">Michael Czisch</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Dale, Anders M" sort="Dale, Anders M" uniqKey="Dale A" first="Anders M." last="Dale">Anders M. Dale</name>
<affiliation>
<nlm:aff id="a143">
<institution>Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich</institution>
, 52425 Jülich,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a144">
<institution>Center for Multimodal Imaging and Genetics, University of California</institution>
, San Diego, California 92093,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Davies, Gareth E" sort="Davies, Gareth E" uniqKey="Davies G" first="Gareth E." last="Davies">Gareth E. Davies</name>
<affiliation>
<nlm:aff id="a145">
<institution>Departments of Neurosciences, Radiology, Psychiatry, and Cognitive Science, University of California</institution>
, San Diego, California 92093,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J. M." last="De Craen">Anton J. M. De Craen</name>
<affiliation>
<nlm:aff id="a146">
<institution>Avera Institute for Human Genetics</institution>
, Sioux Falls, South Dakota 57108,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name>
<affiliation>
<nlm:aff id="a48">
<institution>Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L." last="De Jager">Philip L. De Jager</name>
<affiliation>
<nlm:aff id="a71">
<institution>Harvard Medical School</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a147">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden, 2300RC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a148">
<institution>Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Brigham and Women's Hospital</institution>
, Boston, Massachusetts, 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a149">
<institution>Harvard Medical School</institution>
, Boston, Massachusetts, 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a150">
<institution>Program in Medical and Population Genetics, Broad Institute</institution>
, Cambridge, Massachusetts, 02142,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="De Zubicaray, Greig I" sort="De Zubicaray, Greig I" uniqKey="De Zubicaray G" first="Greig I." last="De Zubicaray">Greig I. De Zubicaray</name>
<affiliation>
<nlm:aff id="a151">
<institution>Broad Institute</institution>
, Cambridge, Massachusetts, 02142,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stéphanie" last="Debette">Stéphanie Debette</name>
<affiliation>
<nlm:aff id="a4">
<institution>INSERM Unit U1219, University of Bordeaux</institution>
, 33076 Bordeaux,
<country>France</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a36">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, Massachusetts,02118,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a152">
<institution>Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT)</institution>
, Brisbane, Queensland 4059,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name>
<affiliation>
<nlm:aff id="a153">
<institution>Department of Neurology, Bordeaux University Hospital</institution>
, Bordeaux, 33076,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Delanty, Norman" sort="Delanty, Norman" uniqKey="Delanty N" first="Norman" last="Delanty">Norman Delanty</name>
<affiliation>
<nlm:aff id="a21">
<institution>The Royal College of Surgeons in Ireland</institution>
, 123 St Stephen's Green, Dublin 2,
<country>Ireland</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a154">
<institution>Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis</institution>
, 4860 Y Street, Suite 3700, Sacramento, California 95817,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Depondt, Chantal" sort="Depondt, Chantal" uniqKey="Depondt C" first="Chantal" last="Depondt">Chantal Depondt</name>
<affiliation>
<nlm:aff id="a155">
<institution>Neurology Division, Beaumont Hospital</institution>
, Dublin 9,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name>
<affiliation>
<nlm:aff id="a37">
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, Massachusetts 02118
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a38">
<institution>Framingham Heart Study</institution>
, 17 Mount Wayte Avenue, Framingham, Massachusetts 01703
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Dillman, Allissa" sort="Dillman, Allissa" uniqKey="Dillman A" first="Allissa" last="Dillman">Allissa Dillman</name>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Djurovic, Srdjan" sort="Djurovic, Srdjan" uniqKey="Djurovic S" first="Srdjan" last="Djurovic">Srdjan Djurovic</name>
<affiliation>
<nlm:aff id="a52">
<institution>NORMENT—KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a156">
<institution>Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles</institution>
, 1070 Brussels,
<country>Belgium</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Donohoe, Gary" sort="Donohoe, Gary" uniqKey="Donohoe G" first="Gary" last="Donohoe">Gary Donohoe</name>
<affiliation>
<nlm:aff id="a157">
<institution>Department of Medical Genetics, Oslo University Hospital</institution>
, 0420 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a158">
<institution>Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition & Genomics Centre (NICOG) & NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway</institution>
, H91 TK33, Galway,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Drevets, Wayne C" sort="Drevets, Wayne C" uniqKey="Drevets W" first="Wayne C." last="Drevets">Wayne C. Drevets</name>
<affiliation>
<nlm:aff id="a83">
<institution>Human Genetics Branch, National Institute of Mental Health Intramural Research Program</institution>
, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a159">
<institution>Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College Dublin</institution>
, Dublin 8,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Duggirala, Ravi" sort="Duggirala, Ravi" uniqKey="Duggirala R" first="Ravi" last="Duggirala">Ravi Duggirala</name>
<affiliation>
<nlm:aff id="a125">
<institution>Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet</institution>
, SE-171 77 Stockholm,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Dyer, Thomas D" sort="Dyer, Thomas D" uniqKey="Dyer T" first="Thomas D." last="Dyer">Thomas D. Dyer</name>
<affiliation>
<nlm:aff id="a125">
<institution>Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet</institution>
, SE-171 77 Stockholm,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Enzinger, Christian" sort="Enzinger, Christian" uniqKey="Enzinger C" first="Christian" last="Enzinger">Christian Enzinger</name>
<affiliation>
<nlm:aff id="a6">
<institution>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz</institution>
, Auenbruggerplatz 22, 8036 Graz,
<country>Austria</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Erk, Susanne" sort="Erk, Susanne" uniqKey="Erk S" first="Susanne" last="Erk">Susanne Erk</name>
<affiliation>
<nlm:aff id="a160">
<institution>Janssen Research & Development, LLC</institution>
, Titusville, New Jersey 08560,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Espeseth, Thomas" sort="Espeseth, Thomas" uniqKey="Espeseth T" first="Thomas" last="Espeseth">Thomas Espeseth</name>
<affiliation>
<nlm:aff id="a32">
<institution>NORMENT—KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital</institution>
, 0424 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a117">
<institution>Department of Psychology, Georgia State University</institution>
, Atlanta, Georgia 30302,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fedko, Iryna O" sort="Fedko, Iryna O" uniqKey="Fedko I" first="Iryna O." last="Fedko">Iryna O. Fedko</name>
<affiliation>
<nlm:aff id="a48">
<institution>Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fernandez, Guillen" sort="Fernandez, Guillen" uniqKey="Fernandez G" first="Guillén" last="Fernández">Guillén Fernández</name>
<affiliation>
<nlm:aff id="a12">
<institution>Department of Cognitive Neuroscience, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<affiliation>
<nlm:aff id="a161">
<institution>Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Department of Psychiatry and Psychotherapy</institution>
, Charitéplatz 1, 10117 Berlin,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fisher, Simon E" sort="Fisher, Simon E" uniqKey="Fisher S" first="Simon E." last="Fisher">Simon E. Fisher</name>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a57">
<institution>Language and Genetics Department, Max Planck Institute for Psycholinguistics</institution>
, 6525 XD Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fleischman, Debra A" sort="Fleischman, Debra A" uniqKey="Fleischman D" first="Debra A." last="Fleischman">Debra A. Fleischman</name>
<affiliation>
<nlm:aff id="a24">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, Illinois 60612,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a162">
<institution>Intramural Research Program of the National Institute on Aging</institution>
, Baltimore, Maryland, 21224,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation>
<nlm:aff id="a163">
<institution>Department of Neurological Sciences & Department of Behavioral Sciences, Rush University Medical Center</institution>
, Chicago, Illinois 60616,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation>
<nlm:aff id="a164">
<institution>Robertson Centre for Biostatistics, University of Glasgow</institution>
, Glasgow, G41 4DQ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M." last="Foroud">Tatiana M. Foroud</name>
<affiliation>
<nlm:aff id="a68">
<institution>Indiana Alzheimer Disease Center, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a165">
<institution>Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston</institution>
, Houston, Texas, 77030,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fox, Peter T" sort="Fox, Peter T" uniqKey="Fox P" first="Peter T." last="Fox">Peter T. Fox</name>
<affiliation>
<nlm:aff id="a166">
<institution>Medical and Molecular Genetics, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Francks, Clyde" sort="Francks, Clyde" uniqKey="Francks C" first="Clyde" last="Francks">Clyde Francks</name>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a57">
<institution>Language and Genetics Department, Max Planck Institute for Psycholinguistics</institution>
, 6525 XD Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Fukunaga, Masaki" sort="Fukunaga, Masaki" uniqKey="Fukunaga M" first="Masaki" last="Fukunaga">Masaki Fukunaga</name>
<affiliation>
<nlm:aff id="a167">
<institution>University of Texas Health Science Center</institution>
, San Antonio, Texas 78229,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gibbs, J Raphael" sort="Gibbs, J Raphael" uniqKey="Gibbs J" first="J. Raphael" last="Gibbs">J. Raphael Gibbs</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C." last="Glahn">David C. Glahn</name>
<affiliation>
<nlm:aff id="a80">
<institution>Department of Psychiatry, Yale University</institution>
, New Haven, Connecticut 06511,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a81">
<institution>Olin Neuropsychiatric Research Center</institution>
, Hartford, Connecticut 06114,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gollub, Randy L" sort="Gollub, Randy L" uniqKey="Gollub R" first="Randy L." last="Gollub">Randy L. Gollub</name>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a51">
<institution>Martinos Center for Biomedical Imaging, Massachusetts General Hospital</institution>
, Charlestown, Massachusetts 02129,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a71">
<institution>Harvard Medical School</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Goring, Harald H H" sort="Goring, Harald H H" uniqKey="Goring H" first="Harald H. H." last="Göring">Harald H. H. Göring</name>
<affiliation>
<nlm:aff id="a125">
<institution>Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet</institution>
, SE-171 77 Stockholm,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Green, Robert C" sort="Green, Robert C" uniqKey="Green R" first="Robert C." last="Green">Robert C. Green</name>
<affiliation>
<nlm:aff id="a71">
<institution>Harvard Medical School</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a168">
<institution>Division of Cerebral Integration, National Institute for Physiological Sciences</institution>
, Aichi, 444-8585,
<country>Japan</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gruber, Oliver" sort="Gruber, Oliver" uniqKey="Gruber O" first="Oliver" last="Gruber">Oliver Gruber</name>
<affiliation>
<nlm:aff id="a69">
<institution>Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University</institution>
, Heidelberg, 69120,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation>
<nlm:aff id="a103">
<institution>Icelandic Heart Association</institution>
, Kopavogur, 201,
<country>Iceland</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a104">
<institution>Faculty of Medicine, University of Iceland</institution>
, Reykjavik, 101,
<country>Iceland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Guelfi, Sebastian" sort="Guelfi, Sebastian" uniqKey="Guelfi S" first="Sebastian" last="Guelfi">Sebastian Guelfi</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="H Berg, Asta K" sort="H Berg, Asta K" uniqKey="H Berg A" first="Asta K." last="H Berg">Asta K. H Berg</name>
<affiliation>
<nlm:aff id="a169">
<institution>Division of Genetics, Department of Medicine, Brigham and Women's Hospital</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a170">
<institution>Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU)</institution>
, Trondheim, 7491,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hansell, Narelle K" sort="Hansell, Narelle K" uniqKey="Hansell N" first="Narelle K." last="Hansell">Narelle K. Hansell</name>
<affiliation>
<nlm:aff id="a8">
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a106">
<institution>Queensland Brain Institute, University of Queensland</institution>
, Brisbane, Queensland 4072,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hartman, Catharina A" sort="Hartman, Catharina A" uniqKey="Hartman C" first="Catharina A." last="Hartman">Catharina A. Hartman</name>
<affiliation>
<nlm:aff id="a114">
<institution>Department of Psychiatry, University of Groningen, University Medical Center Groningen</institution>
, Groningen, 9700RB,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hashimoto, Ryota" sort="Hashimoto, Ryota" uniqKey="Hashimoto R" first="Ryota" last="Hashimoto">Ryota Hashimoto</name>
<affiliation>
<nlm:aff id="a171">
<institution>Department of Radiology, St. Olav's Hospital, Trondheim University Hospital</institution>
, Trondheim, 7030,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a172">
<institution>Department of Psychiatry, Osaka University Graduate School of Medicine</institution>
, Osaka 565-0871,
<country>Japan</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hegenscheid, Katrin" sort="Hegenscheid, Katrin" uniqKey="Hegenscheid K" first="Katrin" last="Hegenscheid">Katrin Hegenscheid</name>
<affiliation>
<nlm:aff id="a173">
<institution>Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University</institution>
, Osaka, 565-0871,
<country>Japan</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Heinz, Andreas" sort="Heinz, Andreas" uniqKey="Heinz A" first="Andreas" last="Heinz">Andreas Heinz</name>
<affiliation>
<nlm:aff id="a160">
<institution>Janssen Research & Development, LLC</institution>
, Titusville, New Jersey 08560,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Le Hellard, Stephanie" sort="Le Hellard, Stephanie" uniqKey="Le Hellard S" first="Stephanie" last="Le Hellard">Stephanie Le Hellard</name>
<affiliation>
<nlm:aff id="a52">
<institution>NORMENT—KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a53">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena G." last="Hernandez">Dena G. Hernandez</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a174">
<institution>Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Heslenfeld, Dirk J" sort="Heslenfeld, Dirk J" uniqKey="Heslenfeld D" first="Dirk J." last="Heslenfeld">Dirk J. Heslenfeld</name>
<affiliation>
<nlm:aff id="a175">
<institution>German Center for Neurodegenerative Diseases (DZNE)</institution>
, Tübingen, 72076,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ho, Beng Choon" sort="Ho, Beng Choon" uniqKey="Ho B" first="Beng-Choon" last="Ho">Beng-Choon Ho</name>
<affiliation>
<nlm:aff id="a176">
<institution>Department of Psychology, VU University Amsterdam</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hoekstra, Pieter J" sort="Hoekstra, Pieter J" uniqKey="Hoekstra P" first="Pieter J." last="Hoekstra">Pieter J. Hoekstra</name>
<affiliation>
<nlm:aff id="a114">
<institution>Department of Psychiatry, University of Groningen, University Medical Center Groningen</institution>
, Groningen, 9700RB,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hoffmann, Wolfgang" sort="Hoffmann, Wolfgang" uniqKey="Hoffmann W" first="Wolfgang" last="Hoffmann">Wolfgang Hoffmann</name>
<affiliation>
<nlm:aff id="a107">
<institution>Institute for Community Medicine, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a120">
<institution>FMRIB Centre, University of Oxford</institution>
, Oxford OX3 9DU,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation>
<nlm:aff id="a178">
<institution>Department of Epidemiology, Harvard T.H. Chan School of Public Health</institution>
, Boston, Massachusetts 02115
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Holsboer, Florian" sort="Holsboer, Florian" uniqKey="Holsboer F" first="Florian" last="Holsboer">Florian Holsboer</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a177">
<institution>Department of Psychiatry, University of Iowa</institution>
, Iowa City, Iowa 52242,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name>
<affiliation>
<nlm:aff id="a178">
<institution>Department of Epidemiology, Harvard T.H. Chan School of Public Health</institution>
, Boston, Massachusetts 02115
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hosten, Norbert" sort="Hosten, Norbert" uniqKey="Hosten N" first="Norbert" last="Hosten">Norbert Hosten</name>
<affiliation>
<nlm:aff id="a173">
<institution>Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University</institution>
, Osaka, 565-0871,
<country>Japan</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name>
<affiliation>
<nlm:aff id="a48">
<institution>Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Huentelman, Matthew" sort="Huentelman, Matthew" uniqKey="Huentelman M" first="Matthew" last="Huentelman">Matthew Huentelman</name>
<affiliation>
<nlm:aff id="a179">
<institution>HMNC Brain Health</institution>
, Munich, 80539,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pol, Hilleke E Hulshoff" sort="Pol, Hilleke E Hulshoff" uniqKey="Pol H" first="Hilleke E. Hulshoff" last="Pol">Hilleke E. Hulshoff Pol</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ikeda, Masashi" sort="Ikeda, Masashi" uniqKey="Ikeda M" first="Masashi" last="Ikeda">Masashi Ikeda</name>
<affiliation>
<nlm:aff id="a180">
<institution>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Jack Jr, Clifford R" sort="Jack Jr, Clifford R" uniqKey="Jack Jr C" first="Clifford R." last="Jack Jr">Clifford R. Jack Jr</name>
<affiliation>
<nlm:aff id="a181">
<institution>Translational Genomics Research Institute, Neurogenomics Division</institution>
, 445N Fifth Street, Phoenix, Arizona 85004,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Jenkinson, Mark" sort="Jenkinson, Mark" uniqKey="Jenkinson M" first="Mark" last="Jenkinson">Mark Jenkinson</name>
<affiliation>
<nlm:aff id="a119">
<institution>Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, Mississippi, 39216,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Johnson, Robert" sort="Johnson, Robert" uniqKey="Johnson R" first="Robert" last="Johnson">Robert Johnson</name>
<affiliation>
<nlm:aff id="a182">
<institution>Department of Psychiatry, Fujita Health University School of Medicine</institution>
, Toyoake 470-1192,
<country>Japan</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Jonsson, Erik G" sort="Jonsson, Erik G" uniqKey="Jonsson E" first="Erik G." last="Jönsson">Erik G. Jönsson</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a124">
<institution>Biospective Inc, Montreal, Quebec, Canada</institution>
, 6100 Avenue Royalmount, Montréal, Québec,
<country>Canada</country>
H4P 2R2</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<affiliation>
<nlm:aff id="a111">
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden, 2300RC,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kahn, Rene S" sort="Kahn, Rene S" uniqKey="Kahn R" first="René S." last="Kahn">René S. Kahn</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kanai, Ryota" sort="Kanai, Ryota" uniqKey="Kanai R" first="Ryota" last="Kanai">Ryota Kanai</name>
<affiliation>
<nlm:aff id="a183">
<institution>Department of Radiology, Mayo Clinic</institution>
, Rochester, Minnesota 55905,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a184">
<institution>NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School</institution>
, Baltimore, Maryland 21201,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a185">
<institution>School of Psychology, University of Sussex</institution>
, Brighton BN1 9QH,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kloszewska">Iwona Kloszewska</name>
<affiliation>
<nlm:aff id="a186">
<institution>Institute of Cognitive Neuroscience, University College London</institution>
, London WC1N 3AR,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S." last="Knopman">David S. Knopman</name>
<affiliation>
<nlm:aff id="a187">
<institution>Department of Neuroinformatics, Araya Brain Imaging</institution>
, Tokyo, 102-0093,
<country>Japan</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kochunov, Peter" sort="Kochunov, Peter" uniqKey="Kochunov P" first="Peter" last="Kochunov">Peter Kochunov</name>
<affiliation>
<nlm:aff id="a188">
<institution>Medical University of Lodz</institution>
, 90-419 Lodz,
<country>Poland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kwok, John B" sort="Kwok, John B" uniqKey="Kwok J" first="John B." last="Kwok">John B. Kwok</name>
<affiliation>
<nlm:aff id="a189">
<institution>Department of Neurology, Mayo Clinic</institution>
, Rochester, Minnesota, 55905,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a190">
<institution>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine</institution>
, Baltimore, Maryland, 21228,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lawrie, Stephen M" sort="Lawrie, Stephen M" uniqKey="Lawrie S" first="Stephen M." last="Lawrie">Stephen M. Lawrie</name>
<affiliation>
<nlm:aff id="a87">
<institution>Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh</institution>
, Edinburgh EH10 5HF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaître">Hervé Lemaître</name>
<affiliation>
<nlm:aff id="a191">
<institution>Neuroscience Research Australia</institution>
, Sydney, New South Wales 2031,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Liu, Xinmin" sort="Liu, Xinmin" uniqKey="Liu X" first="Xinmin" last="Liu">Xinmin Liu</name>
<affiliation>
<nlm:aff id="a83">
<institution>Human Genetics Branch, National Institute of Mental Health Intramural Research Program</institution>
, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a192">
<institution>School of Medical Sciences, UNSW</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Longo, Dan L" sort="Longo, Dan L" uniqKey="Longo D" first="Dan L." last="Longo">Dan L. Longo</name>
<affiliation>
<nlm:aff id="a193">
<institution>INSERM UMR 1000 “Neuroimaging and Psychiatry”, Service Hospitalier Frédéric Joliot; University Paris-Sud, Université Paris-Saclay, University Paris Descartes</institution>
, Maison de Solenn, Paris, 91400,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name>
<affiliation>
<nlm:aff id="a194">
<institution>Columbia University Medical Center</institution>
, New York, New York 10032,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name>
<affiliation>
<nlm:aff id="a195">
<institution>Laboratory of Genetics, National Institute on Aging, National Institutes of Health</institution>
, Baltimore, Maryland 21224,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a196">
<institution>Departments of Neurology and Psychiatry, University of Pittsburgh</institution>
, 3501 Forbes Ave., Suite 830, Pittsburgh Pennsylvania 15213,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Martinez, Oliver" sort="Martinez, Oliver" uniqKey="Martinez O" first="Oliver" last="Martinez">Oliver Martinez</name>
<affiliation>
<nlm:aff id="a153">
<institution>Department of Neurology, Bordeaux University Hospital</institution>
, Bordeaux, 33076,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Martinot, Jean Luc" sort="Martinot, Jean Luc" uniqKey="Martinot J" first="Jean-Luc" last="Martinot">Jean-Luc Martinot</name>
<affiliation>
<nlm:aff id="a191">
<institution>Neuroscience Research Australia</institution>
, Sydney, New South Wales 2031,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mattay, Venkata S" sort="Mattay, Venkata S" uniqKey="Mattay V" first="Venkata S." last="Mattay">Venkata S. Mattay</name>
<affiliation>
<nlm:aff id="a44">
<institution>Lieber Institute for Brain Development</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a54">
<institution>Department of Neurology, Johns Hopkins University School of Medicine</institution>
, Baltimore, Maryland 21287,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a197">
<institution>Department of Psychiatry, University of Oxford</institution>
, Oxford OX3 7JX,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mcdonald, Colm" sort="Mcdonald, Colm" uniqKey="Mcdonald C" first="Colm" last="Mcdonald">Colm Mcdonald</name>
<affiliation>
<nlm:aff id="a138">
<institution>Department of ECE, University of New Mexico</institution>
, Albuquerque, New Mexico 87131,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mcintosh, Andrew M" sort="Mcintosh, Andrew M" uniqKey="Mcintosh A" first="Andrew M." last="Mcintosh">Andrew M. Mcintosh</name>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a87">
<institution>Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh</institution>
, Edinburgh EH10 5HF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mcmahon, Francis J" sort="Mcmahon, Francis J" uniqKey="Mcmahon F" first="Francis J." last="Mcmahon">Francis J. Mcmahon</name>
<affiliation>
<nlm:aff id="a83">
<institution>Human Genetics Branch, National Institute of Mental Health Intramural Research Program</institution>
, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L." last="Mcmahon">Katie L. Mcmahon</name>
<affiliation>
<nlm:aff id="a198">
<institution>Department of Radiology, Johns Hopkins University School of Medicine</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name>
<affiliation>
<nlm:aff id="a199">
<institution>Centre for Advanced Imaging, University of Queensland</institution>
, Brisbane, Queensland 4072,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Melle, Ingrid" sort="Melle, Ingrid" uniqKey="Melle I" first="Ingrid" last="Melle">Ingrid Melle</name>
<affiliation>
<nlm:aff id="a31">
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a32">
<institution>NORMENT—KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital</institution>
, 0424 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Meyer Lindenberg, Andreas" sort="Meyer Lindenberg, Andreas" uniqKey="Meyer Lindenberg A" first="Andreas" last="Meyer-Lindenberg">Andreas Meyer-Lindenberg</name>
<affiliation>
<nlm:aff id="a55">
<institution>Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg</institution>
, 68159 Mannheim,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mohnke, Sebastian" sort="Mohnke, Sebastian" uniqKey="Mohnke S" first="Sebastian" last="Mohnke">Sebastian Mohnke</name>
<affiliation>
<nlm:aff id="a160">
<institution>Janssen Research & Development, LLC</institution>
, Titusville, New Jersey 08560,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name>
<affiliation>
<nlm:aff id="a8">
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Morris, Derek W" sort="Morris, Derek W" uniqKey="Morris D" first="Derek W." last="Morris">Derek W. Morris</name>
<affiliation>
<nlm:aff id="a157">
<institution>Department of Medical Genetics, Oslo University Hospital</institution>
, 0420 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<affiliation>
<nlm:aff id="a118">
<institution>NORMENT—KG Jebsen Centre, Department of Psychology, University of Oslo</institution>
, 0317 Oslo,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name>
<affiliation>
<nlm:aff id="a141">
<institution>Division of Medical Genetics, Department of Biomedicine, University of Basel</institution>
, 4031 Basel,
<country>Switzerland</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a142">
<institution>Institute of Human Genetics, University of Bonn</institution>
, 53127 Bonn,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name>
<affiliation>
<nlm:aff id="a61">
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a200">
<institution>Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia</institution>
, 06132 Perugia,
<country>Italy</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a201">
<institution>Munich Cluster for Systems Neurology (SyNergy)</institution>
, 81377 Munich,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name>
<affiliation>
<nlm:aff id="a202">
<institution>University of Liverpool, Institute of Translational Medicine</institution>
, Liverpool L69 3BX,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a203">
<institution>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nichols, Thomas E" sort="Nichols, Thomas E" uniqKey="Nichols T" first="Thomas E." last="Nichols">Thomas E. Nichols</name>
<affiliation>
<nlm:aff id="a119">
<institution>Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, Mississippi, 39216,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a204">
<institution>German Center for Cardiovascular Research (DZHK e.V.), partner site Greifswald</institution>
, Greifswald, 17475,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name>
<affiliation>
<nlm:aff id="a3">
<institution>Department of Radiology and Nuclear Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a205">
<institution>Department of Statistics & WMG, University of Warwick</institution>
, Coventry CV4 7AL,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a206">
<institution>Department of Medical Informatics Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name>
<affiliation>
<nlm:aff id="a141">
<institution>Division of Medical Genetics, Department of Biomedicine, University of Basel</institution>
, 4031 Basel,
<country>Switzerland</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a207">
<institution>Faculty of Applied Sciences, Delft University of Technology</institution>
, Delft, 2628 CD,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nyberg, Lars" sort="Nyberg, Lars" uniqKey="Nyberg L" first="Lars" last="Nyberg">Lars Nyberg</name>
<affiliation>
<nlm:aff id="a22">
<institution>Department of Integrative Medical Biology and Umeå Center for Functional Brain Imaging, Umeå University</institution>
, 901 87 Umeå,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ohi, Kazutaka" sort="Ohi, Kazutaka" uniqKey="Ohi K" first="Kazutaka" last="Ohi">Kazutaka Ohi</name>
<affiliation>
<nlm:aff id="a171">
<institution>Department of Radiology, St. Olav's Hospital, Trondheim University Hospital</institution>
, Trondheim, 7030,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L." last="Olvera">Rene L. Olvera</name>
<affiliation>
<nlm:aff id="a166">
<institution>Medical and Molecular Genetics, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ophoff, Roel A" sort="Ophoff, Roel A" uniqKey="Ophoff R" first="Roel A." last="Ophoff">Roel A. Ophoff</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a85">
<institution>Center for Neurobehavioral Genetics, University of California</institution>
, Los Angeles, California 90095,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pandolfo, Massimo" sort="Pandolfo, Massimo" uniqKey="Pandolfo M" first="Massimo" last="Pandolfo">Massimo Pandolfo</name>
<affiliation>
<nlm:aff id="a155">
<institution>Neurology Division, Beaumont Hospital</institution>
, Dublin 9,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Paus, Tomas" sort="Paus, Tomas" uniqKey="Paus T" first="Tomas" last="Paus">Tomas Paus</name>
<affiliation>
<nlm:aff id="a208">
<institution>Department of Genomics, Life & Brain Center, University of Bonn</institution>
, 53127 Bonn,
<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a209">
<institution>Rotman Research Institute, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M6A 2E1</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a210">
<institution>Departments of Psychology and Psychiatry, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M5T 1R8</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pausova, Zdenka" sort="Pausova, Zdenka" uniqKey="Pausova Z" first="Zdenka" last="Pausova">Zdenka Pausova</name>
<affiliation>
<nlm:aff id="a39">
<institution>Hospital for Sick Children, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M5G 1X8</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a211">
<institution>Child Mind Institute</institution>
, New York, New York, 10022,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Penninx, Brenda W J H" sort="Penninx, Brenda W J H" uniqKey="Penninx B" first="Brenda W. J. H." last="Penninx">Brenda W. J. H. Penninx</name>
<affiliation>
<nlm:aff id="a100">
<institution>Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center</institution>
, 1007 MB Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Pike, G Bruce" sort="Pike, G Bruce" uniqKey="Pike G" first="G. Bruce" last="Pike">G. Bruce Pike</name>
<affiliation>
<nlm:aff id="a212">
<institution>Departments of Physiology and Nutritional Sciences, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M5S 3E2</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a213">
<institution>Department of Radiology, University of Calgary</institution>
, Calgary, Alberta,
<country>Canada</country>
T2N 4N1</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Potkin, Steven G" sort="Potkin, Steven G" uniqKey="Potkin S" first="Steven G." last="Potkin">Steven G. Potkin</name>
<affiliation>
<nlm:aff id="a116">
<institution>Department of Psychiatry and Human Behavior, University of California-Irvine</institution>
, Irvine, California 92617,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<affiliation>
<nlm:aff id="a214">
<institution>Department of Clinical Neuroscience, University of Calgary</institution>
, Calgary, Alberta,
<country>Canada</country>
T2N 4N1</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Reppermund, Simone" sort="Reppermund, Simone" uniqKey="Reppermund S" first="Simone" last="Reppermund">Simone Reppermund</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a215">
<institution>Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, USA Group Health Research Institute, Group Health</institution>
, 1730 Minor Avenue/Suite 1360, Seattle, Washington 98101,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name>
<affiliation>
<nlm:aff id="a55">
<institution>Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg</institution>
, 68159 Mannheim,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Roffman, Joshua L" sort="Roffman, Joshua L" uniqKey="Roffman J" first="Joshua L." last="Roffman">Joshua L. Roffman</name>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Romanczuk Seiferth, Nina" sort="Romanczuk Seiferth, Nina" uniqKey="Romanczuk Seiferth N" first="Nina" last="Romanczuk-Seiferth">Nina Romanczuk-Seiferth</name>
<affiliation>
<nlm:aff id="a160">
<institution>Janssen Research & Development, LLC</institution>
, Titusville, New Jersey 08560,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name>
<affiliation>
<nlm:aff id="a216">
<institution>Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ryten, Mina" sort="Ryten, Mina" uniqKey="Ryten M" first="Mina" last="Ryten">Mina Ryten</name>
<affiliation>
<nlm:aff id="a76">
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a89">
<institution>Department of Medical and Molecular Genetics, King's College London</institution>
, London SE1 9RT,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sacco, Ralph L" sort="Sacco, Ralph L" uniqKey="Sacco R" first="Ralph L." last="Sacco">Ralph L. Sacco</name>
<affiliation>
<nlm:aff id="a35">
<institution>John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a96">
<institution>Department of Neurology, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a97">
<institution>Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a217">
<institution>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center</institution>
, Torrance, California 90502,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S." last="Sachdev">Perminder S. Sachdev</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a218">
<institution>Evelyn F. McKnight Brain Institute, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Saykin, Andrew J" sort="Saykin, Andrew J" uniqKey="Saykin A" first="Andrew J." last="Saykin">Andrew J. Saykin</name>
<affiliation>
<nlm:aff id="a66">
<institution>Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a68">
<institution>Indiana Alzheimer Disease Center, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a165">
<institution>Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston</institution>
, Houston, Texas, 77030,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation>
<nlm:aff id="a6">
<institution>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz</institution>
, Auenbruggerplatz 22, 8036 Graz,
<country>Austria</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation>
<nlm:aff id="a219">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Randwick, New South Wales 2031,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name>
<affiliation>
<nlm:aff id="a189">
<institution>Department of Neurology, Mayo Clinic</institution>
, Rochester, Minnesota, 55905,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a190">
<institution>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine</institution>
, Baltimore, Maryland, 21228,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sigursson, Sigurdur" sort="Sigursson, Sigurdur" uniqKey="Sigursson S" first="Sigurdur" last="Sigursson">Sigurdur Sigursson</name>
<affiliation>
<nlm:aff id="a103">
<institution>Icelandic Heart Association</institution>
, Kopavogur, 201,
<country>Iceland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Simmons, Andrew" sort="Simmons, Andrew" uniqKey="Simmons A" first="Andrew" last="Simmons">Andrew Simmons</name>
<affiliation>
<nlm:aff id="a220">
<institution>Institute of Molecular Biology and Biochemistry, Medical University Graz</institution>
, Harrachgasse 21/III, 8010 Graz,
<country>Austria</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a221">
<institution>Department of Neuroimaging, Institute of Psychiatry, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a222">
<institution>Biomedical Research Centre for Mental Health, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sisodiya, Sanjay M" sort="Sisodiya, Sanjay M" uniqKey="Sisodiya S" first="Sanjay M." last="Sisodiya">Sanjay M. Sisodiya</name>
<affiliation>
<nlm:aff id="a64">
<institution>UCL Institute of Neurology, London, United Kingdom and Epilepsy Society</institution>
, Bucks, SL9 0RJ,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Smith, Colin" sort="Smith, Colin" uniqKey="Smith C" first="Colin" last="Smith">Colin Smith</name>
<affiliation>
<nlm:aff id="a223">
<institution>Biomedical Research Unit for Dementia, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Smoller, Jordan W" sort="Smoller, Jordan W" uniqKey="Smoller J" first="Jordan W." last="Smoller">Jordan W. Smoller</name>
<affiliation>
<nlm:aff id="a50">
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a70">
<institution>Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a71">
<institution>Harvard Medical School</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a72">
<institution>Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard</institution>
, Boston, Massachusetts 02141,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name>
<affiliation>
<nlm:aff id="a224">
<institution>MRC Edinburgh Brain Bank, University of Edinburgh, Academic Department of Neuropathology, Centre for Clinical Brain Sciences</institution>
, Edinburgh, EH16 4SB
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a225">
<institution>Institute of Clinical Medicine, Neurology, University of Eastern Finland</institution>
, FI-70211 Kuopio,
<country>Finland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Steen, Vidar M" sort="Steen, Vidar M" uniqKey="Steen V" first="Vidar M." last="Steen">Vidar M. Steen</name>
<affiliation>
<nlm:aff id="a52">
<institution>NORMENT—KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a53">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, 5021 Bergen,
<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J." last="Stott">David J. Stott</name>
<affiliation>
<nlm:aff id="a226">
<institution>Neurocentre Neurology, Kuopio University Hospital</institution>
, FI-70211 Kuopio,
<country>Finland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sussmann, Jessika E" sort="Sussmann, Jessika E" uniqKey="Sussmann J" first="Jessika E." last="Sussmann">Jessika E. Sussmann</name>
<affiliation>
<nlm:aff id="a87">
<institution>Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh</institution>
, Edinburgh EH10 5HF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Thalamuthu, Anbupalam" sort="Thalamuthu, Anbupalam" uniqKey="Thalamuthu A" first="Anbupalam" last="Thalamuthu">Anbupalam Thalamuthu</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W." last="Toga">Arthur W. Toga</name>
<affiliation>
<nlm:aff id="a227">
<institution>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow</institution>
, Glasgow, G4 0SF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Traynor, Bryan J" sort="Traynor, Bryan J" uniqKey="Traynor B" first="Bryan J." last="Traynor">Bryan J. Traynor</name>
<affiliation>
<nlm:aff id="a130">
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Troncoso, Juan" sort="Troncoso, Juan" uniqKey="Troncoso J" first="Juan" last="Troncoso">Juan Troncoso</name>
<affiliation>
<nlm:aff id="a228">
<institution>Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine of the University of Southern California</institution>
, Los Angeles, California 90033,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name>
<affiliation>
<nlm:aff id="a229">
<institution>Department of Pathology, Johns Hopkins University</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation>
<nlm:aff id="a4">
<institution>INSERM Unit U1219, University of Bordeaux</institution>
, 33076 Bordeaux,
<country>France</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a230">
<institution>3rd Department of Neurology, "G. Papanicolaou", Hospital, Aristotle University of Thessaloniki</institution>
, Thessaloniki, 57010,
<country>Greece</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation>
<nlm:aff id="a2">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a231">
<institution>Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR1219</institution>
, Bordeaux, F-33000,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hernandez, Maria C Valdes" sort="Hernandez, Maria C Valdes" uniqKey="Hernandez M" first="Maria C. Valdés" last="Hernández">Maria C. Valdés Hernández</name>
<affiliation>
<nlm:aff id="a26">
<institution>Brain Research Imaging Centre, University of Edinburgh</institution>
, Edinburgh EH4 2XU,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a28">
<institution>Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a95">
<institution>Centre for Clinical Brain Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Der Brug, Marcel" sort="Van Der Brug, Marcel" uniqKey="Van Der Brug M" first="Marcel" last="Van Der Brug">Marcel Van Der Brug</name>
<affiliation>
<nlm:aff id="a232">
<institution>Department of Internal Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name>
<affiliation>
<nlm:aff id="a3">
<institution>Department of Radiology and Nuclear Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Der Wee, Nic J A" sort="Van Der Wee, Nic J A" uniqKey="Van Der Wee N" first="Nic J. A." last="Van Der Wee">Nic J. A. Van Der Wee</name>
<affiliation>
<nlm:aff id="a233">
<institution>Genentech Inc.</institution>
, South San Francisco, California 94080,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Haren, Neeltje E M" sort="Van Haren, Neeltje E M" uniqKey="Van Haren N" first="Neeltje E. M." last="Van Haren">Neeltje E. M. Van Haren</name>
<affiliation>
<nlm:aff id="a19">
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van T Ent, Dennis" sort="Van T Ent, Dennis" uniqKey="Van T Ent D" first="Dennis" last="Van T Ent">Dennis Van T Ent</name>
<affiliation>
<nlm:aff id="a48">
<institution>Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Tol, Marie Jose" sort="Van Tol, Marie Jose" uniqKey="Van Tol M" first="Marie-Jose" last="Van Tol">Marie-Jose Van Tol</name>
<affiliation>
<nlm:aff id="a234">
<institution>Department of Psychiatry and Leiden Institute for Brain and Cognition, Leiden University Medical Center</institution>
, 2333 ZA Leiden,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N." last="Vardarajan">Badri N. Vardarajan</name>
<affiliation>
<nlm:aff id="a40">
<institution>Taub Institute for Research on Alzheimer's Disease and the Aging Brain; G.H. Sergievsky Center; Department of Neurology. Columbia University Medical Center</institution>
, 639 West 1168th Street, New York, New York 10032,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name>
<affiliation>
<nlm:aff id="a235">
<institution>University of Groningen, University Medical Center Groningen, Department of Neuroscience</institution>
, 9713 AW Groningen,
<country>the Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Veltman, Dick J" sort="Veltman, Dick J" uniqKey="Veltman D" first="Dick J." last="Veltman">Dick J. Veltman</name>
<affiliation>
<nlm:aff id="a100">
<institution>Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center</institution>
, 1007 MB Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<affiliation>
<nlm:aff id="a107">
<institution>Institute for Community Medicine, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Walter, Henrik" sort="Walter, Henrik" uniqKey="Walter H" first="Henrik" last="Walter">Henrik Walter</name>
<affiliation>
<nlm:aff id="a160">
<institution>Janssen Research & Development, LLC</institution>
, Titusville, New Jersey 08560,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M." last="Wardlaw">Joanna M. Wardlaw</name>
<affiliation>
<nlm:aff id="a26">
<institution>Brain Research Imaging Centre, University of Edinburgh</institution>
, Edinburgh EH4 2XU,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a28">
<institution>Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a74">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a95">
<institution>Centre for Clinical Brain Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wassink, Thomas H" sort="Wassink, Thomas H" uniqKey="Wassink T" first="Thomas H." last="Wassink">Thomas H. Wassink</name>
<affiliation>
<nlm:aff id="a236">
<institution>Department of Internal Medicine and Geriatric Medicine, INSERM U1027, University of Toulouse</institution>
, Toulouse, 31024,
<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Weale, Michael E" sort="Weale, Michael E" uniqKey="Weale M" first="Michael E." last="Weale">Michael E. Weale</name>
<affiliation>
<nlm:aff id="a89">
<institution>Department of Medical and Molecular Genetics, King's College London</institution>
, London SE1 9RT,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Weinberger, Daniel R" sort="Weinberger, Daniel R" uniqKey="Weinberger D" first="Daniel R." last="Weinberger">Daniel R. Weinberger</name>
<affiliation>
<nlm:aff id="a44">
<institution>Lieber Institute for Brain Development</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a237">
<institution>Department of Psychiatry, Carver College of Medicine, University of Iowa</institution>
, Iowa City, Iowa 52242,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Weiner, Michael W" sort="Weiner, Michael W" uniqKey="Weiner M" first="Michael W." last="Weiner">Michael W. Weiner</name>
<affiliation>
<nlm:aff id="a238">
<institution>Departments of Psychiatry, Neurology, Neuroscience and the Institute of Genetic Medicine, Johns Hopkins University School of Medicine</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wen, Wei" sort="Wen, Wei" uniqKey="Wen W" first="Wei" last="Wen">Wei Wen</name>
<affiliation>
<nlm:aff id="a29">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a218">
<institution>Evelyn F. McKnight Brain Institute, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Westman, Eric" sort="Westman, Eric" uniqKey="Westman E" first="Eric" last="Westman">Eric Westman</name>
<affiliation>
<nlm:aff id="a239">
<institution>Center for Imaging of Neurodegenerative Disease, San Francisco VA Medical Center, University of California</institution>
, San Francisco, California 94121,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="White, Tonya" sort="White, Tonya" uniqKey="White T" first="Tonya" last="White">Tonya White</name>
<affiliation>
<nlm:aff id="a3">
<institution>Department of Radiology and Nuclear Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a240">
<institution>Department of Neurobiology, Care Sciences and Society, Karolinska Institutet</institution>
, SE-141 57 Huddinge,
<country>Sweden</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wong, Tien Y" sort="Wong, Tien Y" uniqKey="Wong T" first="Tien Y." last="Wong">Tien Y. Wong</name>
<affiliation>
<nlm:aff id="a14">
<institution>Academic Medicine Research Institute, Duke-NUS Graduate Medical School</institution>
, Singapore, 169857,
<country>Singapore</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a15">
<institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>
, Singapore, 168751,
<country>Singapore</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a139">
<institution>Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway</institution>
, H91 TK33 Galway,
<country>Ireland</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wright, Clinton B" sort="Wright, Clinton B" uniqKey="Wright C" first="Clinton B." last="Wright">Clinton B. Wright</name>
<affiliation>
<nlm:aff id="a96">
<institution>Department of Neurology, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a97">
<institution>Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a217">
<institution>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center</institution>
, Torrance, California 90502,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zielke, Ronald H" sort="Zielke, Ronald H" uniqKey="Zielke R" first="Ronald H." last="Zielke">Ronald H. Zielke</name>
<affiliation>
<nlm:aff id="a182">
<institution>Department of Psychiatry, Fujita Health University School of Medicine</institution>
, Toyoake 470-1192,
<country>Japan</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zonderman, Alan B" sort="Zonderman, Alan B" uniqKey="Zonderman A" first="Alan B." last="Zonderman">Alan B. Zonderman</name>
<affiliation>
<nlm:aff id="a241">
<institution>Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation>
<nlm:aff id="a8">
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation>
<nlm:aff id="a2">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name>
<affiliation>
<nlm:aff id="a106">
<institution>Queensland Brain Institute, University of Queensland</institution>
, Brisbane, Queensland 4072,
<country>Australia</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a198">
<institution>Department of Radiology, Johns Hopkins University School of Medicine</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W. T." last="Longstreth">W. T. Longstreth</name>
<affiliation>
<nlm:aff id="a242">
<institution>Laboratory of Epidemiology & Population Sciences, National Institute on Aging, National Institutes of Health</institution>
, Bethesda, Maryland 20892,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Schumann, Gunter" sort="Schumann, Gunter" uniqKey="Schumann G" first="Gunter" last="Schumann">Gunter Schumann</name>
<affiliation>
<nlm:aff id="a18">
<institution>MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Grabe, Hans J" sort="Grabe, Hans J" uniqKey="Grabe H" first="Hans J." last="Grabe">Hans J. Grabe</name>
<affiliation>
<nlm:aff id="a63">
<institution>Department of Psychiatry, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name>
<affiliation>
<nlm:aff id="a10">
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a11">
<institution>Department of Psychiatry, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a13">
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation>
<nlm:aff id="a243">
<institution>Departments of Neurology and Epidemiology, University of Washington</institution>
, 325 Ninth Avenue, Seattle, Washington 98104-2420,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name>
<affiliation>
<nlm:aff id="a8">
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation>
<nlm:aff id="a36">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, Massachusetts,02118,
<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a38">
<institution>Framingham Heart Study</institution>
, 17 Mount Wayte Avenue, Framingham, Massachusetts 01703
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
<affiliation>
<nlm:aff id="a1">
<institution>Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California</institution>
, Los Angeles, California 90292,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name>
<affiliation>
<nlm:aff id="a2">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a3">
<institution>Department of Radiology and Nuclear Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="a244">
<institution>Intramural Research Program, NIA, NIH</institution>
, 7201 Wisconsin Ave, Suite 3C-309, Bethesda, Maryland 20892,
<country>USA</country>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Nature Communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint>
<date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (
<italic>ASTN2</italic>
,
<italic>DPP4</italic>
and
<italic>MAST4</italic>
) and one is found 200 kb upstream of
<italic>SHH</italic>
. A hippocampal subfield analysis shows that a locus within the
<italic>MSRB3</italic>
gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (
<italic>r</italic>
<sub>g</sub>
=−0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.</p>
</div>
</front>
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</TEI>
<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Nat Commun</journal-id>
<journal-id journal-id-type="iso-abbrev">Nat Commun</journal-id>
<journal-title-group>
<journal-title>Nature Communications</journal-title>
</journal-title-group>
<issn pub-type="epub">2041-1723</issn>
<publisher>
<publisher-name>Nature Publishing Group</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">28098162</article-id>
<article-id pub-id-type="pmc">5253632</article-id>
<article-id pub-id-type="pii">ncomms13624</article-id>
<article-id pub-id-type="doi">10.1038/ncomms13624</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Novel genetic loci associated with hippocampal volume</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Hibar</surname>
<given-names>Derrek P.</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
<xref ref-type="author-notes" rid="n1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Adams</surname>
<given-names>Hieab H. H.</given-names>
</name>
<xref ref-type="aff" rid="a2">2</xref>
<xref ref-type="aff" rid="a3">3</xref>
<xref ref-type="author-notes" rid="n1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jahanshad</surname>
<given-names>Neda</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
<xref ref-type="author-notes" rid="n1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chauhan</surname>
<given-names>Ganesh</given-names>
</name>
<xref ref-type="aff" rid="a4">4</xref>
<xref ref-type="author-notes" rid="n1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Stein</surname>
<given-names>Jason L.</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
<xref ref-type="aff" rid="a5">5</xref>
<xref ref-type="author-notes" rid="n1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hofer</surname>
<given-names>Edith</given-names>
</name>
<xref ref-type="aff" rid="a6">6</xref>
<xref ref-type="aff" rid="a7">7</xref>
<xref ref-type="author-notes" rid="n1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Renteria</surname>
<given-names>Miguel E.</given-names>
</name>
<xref ref-type="aff" rid="a8">8</xref>
<xref ref-type="author-notes" rid="n1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bis</surname>
<given-names>Joshua C.</given-names>
</name>
<xref ref-type="aff" rid="a9">9</xref>
<xref ref-type="author-notes" rid="n1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Arias-Vasquez</surname>
<given-names>Alejandro</given-names>
</name>
<xref ref-type="aff" rid="a10">10</xref>
<xref ref-type="aff" rid="a11">11</xref>
<xref ref-type="aff" rid="a12">12</xref>
<xref ref-type="aff" rid="a13">13</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ikram</surname>
<given-names>M. Kamran</given-names>
</name>
<xref ref-type="aff" rid="a2">2</xref>
<xref ref-type="aff" rid="a14">14</xref>
<xref ref-type="aff" rid="a15">15</xref>
<xref ref-type="aff" rid="a16">16</xref>
<xref ref-type="aff" rid="a17">17</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Desrivières</surname>
<given-names>Sylvane</given-names>
</name>
<xref ref-type="aff" rid="a18">18</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Vernooij</surname>
<given-names>Meike W.</given-names>
</name>
<xref ref-type="aff" rid="a2">2</xref>
<xref ref-type="aff" rid="a3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Abramovic</surname>
<given-names>Lucija</given-names>
</name>
<xref ref-type="aff" rid="a19">19</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Alhusaini</surname>
<given-names>Saud</given-names>
</name>
<xref ref-type="aff" rid="a20">20</xref>
<xref ref-type="aff" rid="a21">21</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Amin</surname>
<given-names>Najaf</given-names>
</name>
<xref ref-type="aff" rid="a2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Andersson</surname>
<given-names>Micael</given-names>
</name>
<xref ref-type="aff" rid="a22">22</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Arfanakis</surname>
<given-names>Konstantinos</given-names>
</name>
<xref ref-type="aff" rid="a23">23</xref>
<xref ref-type="aff" rid="a24">24</xref>
<xref ref-type="aff" rid="a25">25</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Aribisala</surname>
<given-names>Benjamin S.</given-names>
</name>
<xref ref-type="aff" rid="a26">26</xref>
<xref ref-type="aff" rid="a27">27</xref>
<xref ref-type="aff" rid="a28">28</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Armstrong</surname>
<given-names>Nicola J.</given-names>
</name>
<xref ref-type="aff" rid="a29">29</xref>
<xref ref-type="aff" rid="a30">30</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Athanasiu</surname>
<given-names>Lavinia</given-names>
</name>
<xref ref-type="aff" rid="a31">31</xref>
<xref ref-type="aff" rid="a32">32</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Axelsson</surname>
<given-names>Tomas</given-names>
</name>
<xref ref-type="aff" rid="a33">33</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Beecham</surname>
<given-names>Ashley H.</given-names>
</name>
<xref ref-type="aff" rid="a34">34</xref>
<xref ref-type="aff" rid="a35">35</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Beiser</surname>
<given-names>Alexa</given-names>
</name>
<xref ref-type="aff" rid="a36">36</xref>
<xref ref-type="aff" rid="a37">37</xref>
<xref ref-type="aff" rid="a38">38</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bernard</surname>
<given-names>Manon</given-names>
</name>
<xref ref-type="aff" rid="a39">39</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Blanton</surname>
<given-names>Susan H.</given-names>
</name>
<xref ref-type="aff" rid="a34">34</xref>
<xref ref-type="aff" rid="a35">35</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bohlken</surname>
<given-names>Marc M.</given-names>
</name>
<xref ref-type="aff" rid="a19">19</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Boks</surname>
<given-names>Marco P.</given-names>
</name>
<xref ref-type="aff" rid="a19">19</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-6163-7484</contrib-id>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bralten</surname>
<given-names>Janita</given-names>
</name>
<xref ref-type="aff" rid="a10">10</xref>
<xref ref-type="aff" rid="a13">13</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Brickman</surname>
<given-names>Adam M.</given-names>
</name>
<xref ref-type="aff" rid="a40">40</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Carmichael</surname>
<given-names>Owen</given-names>
</name>
<xref ref-type="aff" rid="a41">41</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chakravarty</surname>
<given-names>M. Mallar</given-names>
</name>
<xref ref-type="aff" rid="a42">42</xref>
<xref ref-type="aff" rid="a43">43</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>Qiang</given-names>
</name>
<xref ref-type="aff" rid="a44">44</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ching</surname>
<given-names>Christopher R. K.</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
<xref ref-type="aff" rid="a45">45</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chouraki</surname>
<given-names>Vincent</given-names>
</name>
<xref ref-type="aff" rid="a36">36</xref>
<xref ref-type="aff" rid="a38">38</xref>
<xref ref-type="aff" rid="a46">46</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cuellar-Partida</surname>
<given-names>Gabriel</given-names>
</name>
<xref ref-type="aff" rid="a8">8</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Crivello</surname>
<given-names>Fabrice</given-names>
</name>
<xref ref-type="aff" rid="a47">47</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Den Braber</surname>
<given-names>Anouk</given-names>
</name>
<xref ref-type="aff" rid="a48">48</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Doan</surname>
<given-names>Nhat Trung</given-names>
</name>
<xref ref-type="aff" rid="a31">31</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ehrlich</surname>
<given-names>Stefan</given-names>
</name>
<xref ref-type="aff" rid="a49">49</xref>
<xref ref-type="aff" rid="a50">50</xref>
<xref ref-type="aff" rid="a51">51</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Giddaluru</surname>
<given-names>Sudheer</given-names>
</name>
<xref ref-type="aff" rid="a52">52</xref>
<xref ref-type="aff" rid="a53">53</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Goldman</surname>
<given-names>Aaron L.</given-names>
</name>
<xref ref-type="aff" rid="a44">44</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gottesman</surname>
<given-names>Rebecca F.</given-names>
</name>
<xref ref-type="aff" rid="a54">54</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Grimm</surname>
<given-names>Oliver</given-names>
</name>
<xref ref-type="aff" rid="a55">55</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Griswold</surname>
<given-names>Michael E.</given-names>
</name>
<xref ref-type="aff" rid="a56">56</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Guadalupe</surname>
<given-names>Tulio</given-names>
</name>
<xref ref-type="aff" rid="a57">57</xref>
<xref ref-type="aff" rid="a58">58</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gutman</surname>
<given-names>Boris A.</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hass</surname>
<given-names>Johanna</given-names>
</name>
<xref ref-type="aff" rid="a59">59</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Haukvik</surname>
<given-names>Unn K.</given-names>
</name>
<xref ref-type="aff" rid="a31">31</xref>
<xref ref-type="aff" rid="a60">60</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hoehn</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="a61">61</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Holmes</surname>
<given-names>Avram J.</given-names>
</name>
<xref ref-type="aff" rid="a50">50</xref>
<xref ref-type="aff" rid="a62">62</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hoogman</surname>
<given-names>Martine</given-names>
</name>
<xref ref-type="aff" rid="a10">10</xref>
<xref ref-type="aff" rid="a13">13</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Janowitz</surname>
<given-names>Deborah</given-names>
</name>
<xref ref-type="aff" rid="a63">63</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jia</surname>
<given-names>Tianye</given-names>
</name>
<xref ref-type="aff" rid="a18">18</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-5399-2953</contrib-id>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jørgensen</surname>
<given-names>Kjetil N.</given-names>
</name>
<xref ref-type="aff" rid="a31">31</xref>
<xref ref-type="aff" rid="a60">60</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Karbalai</surname>
<given-names>Nazanin</given-names>
</name>
<xref ref-type="aff" rid="a61">61</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kasperaviciute</surname>
<given-names>Dalia</given-names>
</name>
<xref ref-type="aff" rid="a64">64</xref>
<xref ref-type="aff" rid="a65">65</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kim</surname>
<given-names>Sungeun</given-names>
</name>
<xref ref-type="aff" rid="a66">66</xref>
<xref ref-type="aff" rid="a67">67</xref>
<xref ref-type="aff" rid="a68">68</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Klein</surname>
<given-names>Marieke</given-names>
</name>
<xref ref-type="aff" rid="a10">10</xref>
<xref ref-type="aff" rid="a13">13</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-8784-5679</contrib-id>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kraemer</surname>
<given-names>Bernd</given-names>
</name>
<xref ref-type="aff" rid="a69">69</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lee</surname>
<given-names>Phil H.</given-names>
</name>
<xref ref-type="aff" rid="a50">50</xref>
<xref ref-type="aff" rid="a70">70</xref>
<xref ref-type="aff" rid="a71">71</xref>
<xref ref-type="aff" rid="a72">72</xref>
<xref ref-type="aff" rid="a73">73</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Liewald</surname>
<given-names>David C. M.</given-names>
</name>
<xref ref-type="aff" rid="a74">74</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lopez</surname>
<given-names>Lorna M.</given-names>
</name>
<xref ref-type="aff" rid="a74">74</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Luciano</surname>
<given-names>Michelle</given-names>
</name>
<xref ref-type="aff" rid="a74">74</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Macare</surname>
<given-names>Christine</given-names>
</name>
<xref ref-type="aff" rid="a18">18</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Marquand</surname>
<given-names>Andre F.</given-names>
</name>
<xref ref-type="aff" rid="a13">13</xref>
<xref ref-type="aff" rid="a75">75</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Matarin</surname>
<given-names>Mar</given-names>
</name>
<xref ref-type="aff" rid="a64">64</xref>
<xref ref-type="aff" rid="a76">76</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mather</surname>
<given-names>Karen A.</given-names>
</name>
<xref ref-type="aff" rid="a29">29</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mattheisen</surname>
<given-names>Manuel</given-names>
</name>
<xref ref-type="aff" rid="a77">77</xref>
<xref ref-type="aff" rid="a78">78</xref>
<xref ref-type="aff" rid="a79">79</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-8442-493X</contrib-id>
</contrib>
<contrib contrib-type="author">
<name>
<surname>McKay</surname>
<given-names>David R.</given-names>
</name>
<xref ref-type="aff" rid="a80">80</xref>
<xref ref-type="aff" rid="a81">81</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Milaneschi</surname>
<given-names>Yuri</given-names>
</name>
<xref ref-type="aff" rid="a82">82</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Muñoz Maniega</surname>
<given-names>Susana</given-names>
</name>
<xref ref-type="aff" rid="a26">26</xref>
<xref ref-type="aff" rid="a28">28</xref>
<xref ref-type="aff" rid="a74">74</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nho</surname>
<given-names>Kwangsik</given-names>
</name>
<xref ref-type="aff" rid="a66">66</xref>
<xref ref-type="aff" rid="a67">67</xref>
<xref ref-type="aff" rid="a68">68</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nugent</surname>
<given-names>Allison C.</given-names>
</name>
<xref ref-type="aff" rid="a83">83</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nyquist</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="a84">84</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Loohuis</surname>
<given-names>Loes M. Olde</given-names>
</name>
<xref ref-type="aff" rid="a85">85</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-3327-7837</contrib-id>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Oosterlaan</surname>
<given-names>Jaap</given-names>
</name>
<xref ref-type="aff" rid="a86">86</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Papmeyer</surname>
<given-names>Martina</given-names>
</name>
<xref ref-type="aff" rid="a87">87</xref>
<xref ref-type="aff" rid="a88">88</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pirpamer</surname>
<given-names>Lukas</given-names>
</name>
<xref ref-type="aff" rid="a6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pütz</surname>
<given-names>Benno</given-names>
</name>
<xref ref-type="aff" rid="a61">61</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ramasamy</surname>
<given-names>Adaikalavan</given-names>
</name>
<xref ref-type="aff" rid="a76">76</xref>
<xref ref-type="aff" rid="a89">89</xref>
<xref ref-type="aff" rid="a90">90</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Richards</surname>
<given-names>Jennifer S.</given-names>
</name>
<xref ref-type="aff" rid="a12">12</xref>
<xref ref-type="aff" rid="a13">13</xref>
<xref ref-type="aff" rid="a91">91</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Risacher</surname>
<given-names>Shannon L.</given-names>
</name>
<xref ref-type="aff" rid="a66">66</xref>
<xref ref-type="aff" rid="a68">68</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Roiz-Santiañez</surname>
<given-names>Roberto</given-names>
</name>
<xref ref-type="aff" rid="a92">92</xref>
<xref ref-type="aff" rid="a93">93</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Rommelse</surname>
<given-names>Nanda</given-names>
</name>
<xref ref-type="aff" rid="a11">11</xref>
<xref ref-type="aff" rid="a13">13</xref>
<xref ref-type="aff" rid="a91">91</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ropele</surname>
<given-names>Stefan</given-names>
</name>
<xref ref-type="aff" rid="a6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Rose</surname>
<given-names>Emma J.</given-names>
</name>
<xref ref-type="aff" rid="a94">94</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Royle</surname>
<given-names>Natalie A.</given-names>
</name>
<xref ref-type="aff" rid="a26">26</xref>
<xref ref-type="aff" rid="a28">28</xref>
<xref ref-type="aff" rid="a74">74</xref>
<xref ref-type="aff" rid="a95">95</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Rundek</surname>
<given-names>Tatjana</given-names>
</name>
<xref ref-type="aff" rid="a96">96</xref>
<xref ref-type="aff" rid="a97">97</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sämann</surname>
<given-names>Philipp G.</given-names>
</name>
<xref ref-type="aff" rid="a61">61</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Saremi</surname>
<given-names>Arvin</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Satizabal</surname>
<given-names>Claudia L.</given-names>
</name>
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<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-1115-4430</contrib-id>
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<contrib contrib-type="author">
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<name>
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<name>
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<name>
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<xref ref-type="aff" rid="a122">122</xref>
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<xref ref-type="aff" rid="a126">126</xref>
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<xref ref-type="aff" rid="a129">129</xref>
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<name>
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<name>
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<xref ref-type="aff" rid="a132">132</xref>
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<name>
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<name>
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<surname>Fedko</surname>
<given-names>Iryna O.</given-names>
</name>
<xref ref-type="aff" rid="a48">48</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fernández</surname>
<given-names>Guillén</given-names>
</name>
<xref ref-type="aff" rid="a12">12</xref>
<xref ref-type="aff" rid="a13">13</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ferrucci</surname>
<given-names>Luigi</given-names>
</name>
<xref ref-type="aff" rid="a161">161</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fisher</surname>
<given-names>Simon E.</given-names>
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<xref ref-type="aff" rid="a13">13</xref>
<xref ref-type="aff" rid="a57">57</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-3132-1996</contrib-id>
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<contrib contrib-type="author">
<name>
<surname>Fleischman</surname>
<given-names>Debra A.</given-names>
</name>
<xref ref-type="aff" rid="a24">24</xref>
<xref ref-type="aff" rid="a162">162</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ford</surname>
<given-names>Ian</given-names>
</name>
<xref ref-type="aff" rid="a163">163</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fornage</surname>
<given-names>Myriam</given-names>
</name>
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</contrib>
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<name>
<surname>Foroud</surname>
<given-names>Tatiana M.</given-names>
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<xref ref-type="aff" rid="a165">165</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fox</surname>
<given-names>Peter T.</given-names>
</name>
<xref ref-type="aff" rid="a166">166</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Francks</surname>
<given-names>Clyde</given-names>
</name>
<xref ref-type="aff" rid="a13">13</xref>
<xref ref-type="aff" rid="a57">57</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fukunaga</surname>
<given-names>Masaki</given-names>
</name>
<xref ref-type="aff" rid="a167">167</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gibbs</surname>
<given-names>J. Raphael</given-names>
</name>
<xref ref-type="aff" rid="a76">76</xref>
<xref ref-type="aff" rid="a130">130</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Glahn</surname>
<given-names>David C.</given-names>
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<xref ref-type="aff" rid="a80">80</xref>
<xref ref-type="aff" rid="a81">81</xref>
</contrib>
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<name>
<surname>Gollub</surname>
<given-names>Randy L.</given-names>
</name>
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<xref ref-type="aff" rid="a51">51</xref>
<xref ref-type="aff" rid="a71">71</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Göring</surname>
<given-names>Harald H. H.</given-names>
</name>
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</contrib>
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<name>
<surname>Green</surname>
<given-names>Robert C.</given-names>
</name>
<xref ref-type="aff" rid="a71">71</xref>
<xref ref-type="aff" rid="a168">168</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gruber</surname>
<given-names>Oliver</given-names>
</name>
<xref ref-type="aff" rid="a69">69</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gudnason</surname>
<given-names>Vilmundur</given-names>
</name>
<xref ref-type="aff" rid="a103">103</xref>
<xref ref-type="aff" rid="a104">104</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Guelfi</surname>
<given-names>Sebastian</given-names>
</name>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Håberg</surname>
<given-names>Asta K.</given-names>
</name>
<xref ref-type="aff" rid="a169">169</xref>
<xref ref-type="aff" rid="a170">170</xref>
</contrib>
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<name>
<surname>Hansell</surname>
<given-names>Narelle K.</given-names>
</name>
<xref ref-type="aff" rid="a8">8</xref>
<xref ref-type="aff" rid="a106">106</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hardy</surname>
<given-names>John</given-names>
</name>
<xref ref-type="aff" rid="a76">76</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hartman</surname>
<given-names>Catharina A.</given-names>
</name>
<xref ref-type="aff" rid="a114">114</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hashimoto</surname>
<given-names>Ryota</given-names>
</name>
<xref ref-type="aff" rid="a171">171</xref>
<xref ref-type="aff" rid="a172">172</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-5941-4238</contrib-id>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hegenscheid</surname>
<given-names>Katrin</given-names>
</name>
<xref ref-type="aff" rid="a173">173</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Heinz</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="a160">160</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Le Hellard</surname>
<given-names>Stephanie</given-names>
</name>
<xref ref-type="aff" rid="a52">52</xref>
<xref ref-type="aff" rid="a53">53</xref>
</contrib>
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<name>
<surname>Hernandez</surname>
<given-names>Dena G.</given-names>
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<xref ref-type="aff" rid="a130">130</xref>
<xref ref-type="aff" rid="a174">174</xref>
</contrib>
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<name>
<surname>Heslenfeld</surname>
<given-names>Dirk J.</given-names>
</name>
<xref ref-type="aff" rid="a175">175</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ho</surname>
<given-names>Beng-Choon</given-names>
</name>
<xref ref-type="aff" rid="a176">176</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-3976-1555</contrib-id>
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<name>
<surname>Hoekstra</surname>
<given-names>Pieter J.</given-names>
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<xref ref-type="aff" rid="a114">114</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hoffmann</surname>
<given-names>Wolfgang</given-names>
</name>
<xref ref-type="aff" rid="a107">107</xref>
<xref ref-type="aff" rid="a120">120</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hofman</surname>
<given-names>Albert</given-names>
</name>
<xref ref-type="aff" rid="a178">178</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Holsboer</surname>
<given-names>Florian</given-names>
</name>
<xref ref-type="aff" rid="a61">61</xref>
<xref ref-type="aff" rid="a177">177</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Homuth</surname>
<given-names>Georg</given-names>
</name>
<xref ref-type="aff" rid="a178">178</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hosten</surname>
<given-names>Norbert</given-names>
</name>
<xref ref-type="aff" rid="a173">173</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hottenga</surname>
<given-names>Jouke-Jan</given-names>
</name>
<xref ref-type="aff" rid="a48">48</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Huentelman</surname>
<given-names>Matthew</given-names>
</name>
<xref ref-type="aff" rid="a179">179</xref>
</contrib>
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<name>
<surname>Pol</surname>
<given-names>Hilleke E. Hulshoff</given-names>
</name>
<xref ref-type="aff" rid="a19">19</xref>
</contrib>
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<name>
<surname>Ikeda</surname>
<given-names>Masashi</given-names>
</name>
<xref ref-type="aff" rid="a180">180</xref>
</contrib>
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<name>
<surname>Jack Jr</surname>
<given-names>Clifford R.</given-names>
</name>
<xref ref-type="aff" rid="a181">181</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jenkinson</surname>
<given-names>Mark</given-names>
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<xref ref-type="aff" rid="a119">119</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Johnson</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="a182">182</xref>
</contrib>
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<name>
<surname>Jönsson</surname>
<given-names>Erik G.</given-names>
</name>
<xref ref-type="aff" rid="a31">31</xref>
<xref ref-type="aff" rid="a124">124</xref>
</contrib>
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<name>
<surname>Jukema</surname>
<given-names>J. Wouter</given-names>
</name>
<xref ref-type="aff" rid="a111">111</xref>
</contrib>
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<name>
<surname>Kahn</surname>
<given-names>René S.</given-names>
</name>
<xref ref-type="aff" rid="a19">19</xref>
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<name>
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<given-names>Ryota</given-names>
</name>
<xref ref-type="aff" rid="a183">183</xref>
<xref ref-type="aff" rid="a184">184</xref>
<xref ref-type="aff" rid="a185">185</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kloszewska</surname>
<given-names>Iwona</given-names>
</name>
<xref ref-type="aff" rid="a186">186</xref>
</contrib>
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<name>
<surname>Knopman</surname>
<given-names>David S.</given-names>
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<xref ref-type="aff" rid="a187">187</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kochunov</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="a188">188</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kwok</surname>
<given-names>John B.</given-names>
</name>
<xref ref-type="aff" rid="a189">189</xref>
<xref ref-type="aff" rid="a190">190</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lawrie</surname>
<given-names>Stephen M.</given-names>
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<xref ref-type="aff" rid="a87">87</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lemaître</surname>
<given-names>Hervé</given-names>
</name>
<xref ref-type="aff" rid="a191">191</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Liu</surname>
<given-names>Xinmin</given-names>
</name>
<xref ref-type="aff" rid="a83">83</xref>
<xref ref-type="aff" rid="a192">192</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Longo</surname>
<given-names>Dan L.</given-names>
</name>
<xref ref-type="aff" rid="a193">193</xref>
</contrib>
<contrib contrib-type="author">
<name>
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<given-names>Oscar L.</given-names>
</name>
<xref ref-type="aff" rid="a194">194</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lovestone</surname>
<given-names>Simon</given-names>
</name>
<xref ref-type="aff" rid="a195">195</xref>
<xref ref-type="aff" rid="a196">196</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Martinez</surname>
<given-names>Oliver</given-names>
</name>
<xref ref-type="aff" rid="a153">153</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Martinot</surname>
<given-names>Jean-Luc</given-names>
</name>
<xref ref-type="aff" rid="a191">191</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mattay</surname>
<given-names>Venkata S.</given-names>
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<xref ref-type="aff" rid="a44">44</xref>
<xref ref-type="aff" rid="a54">54</xref>
<xref ref-type="aff" rid="a197">197</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>McDonald</surname>
<given-names>Colm</given-names>
</name>
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</contrib>
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<name>
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<given-names>Andrew M.</given-names>
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<xref ref-type="aff" rid="a87">87</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-0198-4588</contrib-id>
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<name>
<surname>McMahon</surname>
<given-names>Francis J.</given-names>
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<xref ref-type="aff" rid="a83">83</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-9469-305X</contrib-id>
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<contrib contrib-type="author">
<name>
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<given-names>Katie L.</given-names>
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<xref ref-type="aff" rid="a198">198</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mecocci</surname>
<given-names>Patrizia</given-names>
</name>
<xref ref-type="aff" rid="a199">199</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Melle</surname>
<given-names>Ingrid</given-names>
</name>
<xref ref-type="aff" rid="a31">31</xref>
<xref ref-type="aff" rid="a32">32</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Meyer-Lindenberg</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="a55">55</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mohnke</surname>
<given-names>Sebastian</given-names>
</name>
<xref ref-type="aff" rid="a160">160</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Montgomery</surname>
<given-names>Grant W.</given-names>
</name>
<xref ref-type="aff" rid="a8">8</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Morris</surname>
<given-names>Derek W.</given-names>
</name>
<xref ref-type="aff" rid="a157">157</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mosley</surname>
<given-names>Thomas H.</given-names>
</name>
<xref ref-type="aff" rid="a118">118</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mühleisen</surname>
<given-names>Thomas W.</given-names>
</name>
<xref ref-type="aff" rid="a141">141</xref>
<xref ref-type="aff" rid="a142">142</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Müller-Myhsok</surname>
<given-names>Bertram</given-names>
</name>
<xref ref-type="aff" rid="a61">61</xref>
<xref ref-type="aff" rid="a200">200</xref>
<xref ref-type="aff" rid="a201">201</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nalls</surname>
<given-names>Michael A.</given-names>
</name>
<xref ref-type="aff" rid="a130">130</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nauck</surname>
<given-names>Matthias</given-names>
</name>
<xref ref-type="aff" rid="a202">202</xref>
<xref ref-type="aff" rid="a203">203</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nichols</surname>
<given-names>Thomas E.</given-names>
</name>
<xref ref-type="aff" rid="a119">119</xref>
<xref ref-type="aff" rid="a204">204</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-4516-5103</contrib-id>
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<name>
<surname>Niessen</surname>
<given-names>Wiro J.</given-names>
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<xref ref-type="aff" rid="a205">205</xref>
<xref ref-type="aff" rid="a206">206</xref>
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<name>
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<given-names>Markus M.</given-names>
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<xref ref-type="aff" rid="a207">207</xref>
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<contrib contrib-type="author">
<name>
<surname>Nyberg</surname>
<given-names>Lars</given-names>
</name>
<xref ref-type="aff" rid="a22">22</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ohi</surname>
<given-names>Kazutaka</given-names>
</name>
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<given-names>Roel A.</given-names>
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<xref ref-type="aff" rid="a85">85</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pandolfo</surname>
<given-names>Massimo</given-names>
</name>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Paus</surname>
<given-names>Tomas</given-names>
</name>
<xref ref-type="aff" rid="a208">208</xref>
<xref ref-type="aff" rid="a209">209</xref>
<xref ref-type="aff" rid="a210">210</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pausova</surname>
<given-names>Zdenka</given-names>
</name>
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<xref ref-type="aff" rid="a211">211</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Penninx</surname>
<given-names>Brenda W. J. H.</given-names>
</name>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Pike</surname>
<given-names>G. Bruce</given-names>
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<xref ref-type="aff" rid="a213">213</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-8924-683X</contrib-id>
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<name>
<surname>Potkin</surname>
<given-names>Steven G.</given-names>
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<xref ref-type="aff" rid="a214">214</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Reppermund</surname>
<given-names>Simone</given-names>
</name>
<xref ref-type="aff" rid="a29">29</xref>
<xref ref-type="aff" rid="a215">215</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Rietschel</surname>
<given-names>Marcella</given-names>
</name>
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<given-names>Joshua L.</given-names>
</name>
<xref ref-type="aff" rid="a50">50</xref>
</contrib>
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<surname>Romanczuk-Seiferth</surname>
<given-names>Nina</given-names>
</name>
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<contrib contrib-type="author">
<name>
<surname>Rotter</surname>
<given-names>Jerome I.</given-names>
</name>
<xref ref-type="aff" rid="a216">216</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ryten</surname>
<given-names>Mina</given-names>
</name>
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<xref ref-type="aff" rid="a89">89</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sacco</surname>
<given-names>Ralph L.</given-names>
</name>
<xref ref-type="aff" rid="a35">35</xref>
<xref ref-type="aff" rid="a96">96</xref>
<xref ref-type="aff" rid="a97">97</xref>
<xref ref-type="aff" rid="a217">217</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sachdev</surname>
<given-names>Perminder S.</given-names>
</name>
<xref ref-type="aff" rid="a29">29</xref>
<xref ref-type="aff" rid="a218">218</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-9595-3220</contrib-id>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Saykin</surname>
<given-names>Andrew J.</given-names>
</name>
<xref ref-type="aff" rid="a66">66</xref>
<xref ref-type="aff" rid="a68">68</xref>
<xref ref-type="aff" rid="a165">165</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-1376-8532</contrib-id>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Schmidt</surname>
<given-names>Reinhold</given-names>
</name>
<xref ref-type="aff" rid="a6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Schmidt</surname>
<given-names>Helena</given-names>
</name>
<xref ref-type="aff" rid="a219">219</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Schofield</surname>
<given-names>Peter R.</given-names>
</name>
<xref ref-type="aff" rid="a189">189</xref>
<xref ref-type="aff" rid="a190">190</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-2967-9662</contrib-id>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sigursson</surname>
<given-names>Sigurdur</given-names>
</name>
<xref ref-type="aff" rid="a103">103</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Simmons</surname>
<given-names>Andrew</given-names>
</name>
<xref ref-type="aff" rid="a220">220</xref>
<xref ref-type="aff" rid="a221">221</xref>
<xref ref-type="aff" rid="a222">222</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Singleton</surname>
<given-names>Andrew</given-names>
</name>
<xref ref-type="aff" rid="a130">130</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sisodiya</surname>
<given-names>Sanjay M.</given-names>
</name>
<xref ref-type="aff" rid="a64">64</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Smith</surname>
<given-names>Colin</given-names>
</name>
<xref ref-type="aff" rid="a223">223</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Smoller</surname>
<given-names>Jordan W.</given-names>
</name>
<xref ref-type="aff" rid="a50">50</xref>
<xref ref-type="aff" rid="a70">70</xref>
<xref ref-type="aff" rid="a71">71</xref>
<xref ref-type="aff" rid="a72">72</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Soininen</surname>
<given-names>Hilkka</given-names>
</name>
<xref ref-type="aff" rid="a224">224</xref>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Steen</surname>
<given-names>Vidar M.</given-names>
</name>
<xref ref-type="aff" rid="a52">52</xref>
<xref ref-type="aff" rid="a53">53</xref>
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<contrib contrib-type="author">
<name>
<surname>Stott</surname>
<given-names>David J.</given-names>
</name>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Sussmann</surname>
<given-names>Jessika E.</given-names>
</name>
<xref ref-type="aff" rid="a87">87</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Thalamuthu</surname>
<given-names>Anbupalam</given-names>
</name>
<xref ref-type="aff" rid="a29">29</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Toga</surname>
<given-names>Arthur W.</given-names>
</name>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Traynor</surname>
<given-names>Bryan J.</given-names>
</name>
<xref ref-type="aff" rid="a130">130</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Troncoso</surname>
<given-names>Juan</given-names>
</name>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Tsolaki</surname>
<given-names>Magda</given-names>
</name>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Tzourio</surname>
<given-names>Christophe</given-names>
</name>
<xref ref-type="aff" rid="a4">4</xref>
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<contrib contrib-type="author">
<name>
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<given-names>Andre G.</given-names>
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<contrib contrib-type="author">
<name>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Van der Brug</surname>
<given-names>Marcel</given-names>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>van der Lugt</surname>
<given-names>Aad</given-names>
</name>
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<contrib contrib-type="author">
<name>
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<given-names>Nic J. A.</given-names>
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<contrib contrib-type="author">
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<given-names>Neeltje E. M.</given-names>
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<contrib contrib-type="author">
<name>
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<given-names>Dennis</given-names>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Van Tol</surname>
<given-names>Marie-Jose</given-names>
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<contrib contrib-type="author">
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<given-names>Badri N.</given-names>
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<contrib contrib-type="author">
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<given-names>Bruno</given-names>
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<contrib contrib-type="author">
<name>
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<given-names>Dick J.</given-names>
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<contrib contrib-type="author">
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<given-names>Henry</given-names>
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<contrib contrib-type="author">
<name>
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<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-9812-6642</contrib-id>
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</contrib>
<contrib contrib-type="author">
<name>
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<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-3115-2977</contrib-id>
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<contrib contrib-type="author">
<name>
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<contrib contrib-type="author">
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<xref ref-type="aff" rid="a15">15</xref>
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<given-names>Clinton B.</given-names>
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<contrib contrib-type="author">
<name>
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<given-names>Ronald H.</given-names>
</name>
<xref ref-type="aff" rid="a182">182</xref>
</contrib>
<contrib contrib-type="author">
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<given-names>Alan B.</given-names>
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<contrib contrib-type="author">
<name>
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<contrib contrib-type="author">
<name>
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<given-names>Cornelia M.</given-names>
</name>
<xref ref-type="aff" rid="a2">2</xref>
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<contrib contrib-type="author">
<name>
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<given-names>Margaret J.</given-names>
</name>
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<contrib contrib-type="author">
<name>
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<given-names>W. T.</given-names>
</name>
<xref ref-type="aff" rid="a242">242</xref>
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<contrib contrib-type="author">
<name>
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<given-names>Gunter</given-names>
</name>
<xref ref-type="aff" rid="a18">18</xref>
<xref ref-type="author-notes" rid="n2">†</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Grabe</surname>
<given-names>Hans J.</given-names>
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<xref ref-type="author-notes" rid="n2">†</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Franke</surname>
<given-names>Barbara</given-names>
</name>
<xref ref-type="aff" rid="a10">10</xref>
<xref ref-type="aff" rid="a11">11</xref>
<xref ref-type="aff" rid="a13">13</xref>
<xref ref-type="author-notes" rid="n2">†</xref>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-4375-6572</contrib-id>
</contrib>
<contrib contrib-type="author">
<name>
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<given-names>Lenore J.</given-names>
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<xref ref-type="author-notes" rid="n2">†</xref>
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<contrib contrib-type="author">
<name>
<surname>Medland</surname>
<given-names>Sarah E.</given-names>
</name>
<xref ref-type="aff" rid="a8">8</xref>
<xref ref-type="author-notes" rid="n2">†</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Seshadri</surname>
<given-names>Sudha</given-names>
</name>
<xref ref-type="aff" rid="a36">36</xref>
<xref ref-type="aff" rid="a38">38</xref>
<xref ref-type="author-notes" rid="n2">†</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Thompson</surname>
<given-names>Paul M.</given-names>
</name>
<xref ref-type="corresp" rid="c1">a</xref>
<xref ref-type="aff" rid="a1">1</xref>
<xref ref-type="author-notes" rid="n2">†</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ikram</surname>
<given-names>M. Arfan</given-names>
</name>
<xref ref-type="corresp" rid="c2">b</xref>
<xref ref-type="aff" rid="a2">2</xref>
<xref ref-type="aff" rid="a3">3</xref>
<xref ref-type="aff" rid="a244">244</xref>
<xref ref-type="author-notes" rid="n2">†</xref>
</contrib>
<aff id="a1">
<label>1</label>
<institution>Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California</institution>
, Los Angeles, California 90292,
<country>USA</country>
</aff>
<aff id="a2">
<label>2</label>
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</aff>
<aff id="a3">
<label>3</label>
<institution>Department of Radiology and Nuclear Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</aff>
<aff id="a4">
<label>4</label>
<institution>INSERM Unit U1219, University of Bordeaux</institution>
, 33076 Bordeaux,
<country>France</country>
</aff>
<aff id="a5">
<label>5</label>
<institution>Department of Genetics & UNC Neuroscience Center, University of North Carolina (UNC)</institution>
, Chapel Hill, North Carolina, 27599,
<country>USA</country>
</aff>
<aff id="a6">
<label>6</label>
<institution>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz</institution>
, Auenbruggerplatz 22, 8036 Graz,
<country>Austria</country>
</aff>
<aff id="a7">
<label>7</label>
<institution>Institute of Medical Informatics, Statistics and Documentation, Medical University Graz</institution>
, Auenbruggerplatz 22, 8036 Graz,
<country>Austria</country>
</aff>
<aff id="a8">
<label>8</label>
<institution>QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland 4006,
<country>Australia</country>
</aff>
<aff id="a9">
<label>9</label>
<institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>
, 1730 Minor Avenue/Suite 1360. Seattle, Washington 98101,
<country>USA</country>
</aff>
<aff id="a10">
<label>10</label>
<institution>Department of Human Genetics, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</aff>
<aff id="a11">
<label>11</label>
<institution>Department of Psychiatry, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</aff>
<aff id="a12">
<label>12</label>
<institution>Department of Cognitive Neuroscience, Radboud University Medical Center</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</aff>
<aff id="a13">
<label>13</label>
<institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University</institution>
, 6525 GA Nijmegen,
<country>The Netherlands</country>
</aff>
<aff id="a14">
<label>14</label>
<institution>Academic Medicine Research Institute, Duke-NUS Graduate Medical School</institution>
, Singapore, 169857,
<country>Singapore</country>
</aff>
<aff id="a15">
<label>15</label>
<institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>
, Singapore, 168751,
<country>Singapore</country>
</aff>
<aff id="a16">
<label>16</label>
<institution>Memory Aging & Cognition Centre (MACC), National University Health System</institution>
, Singapore, 119228,
<country>Singapore</country>
</aff>
<aff id="a17">
<label>17</label>
<institution>Department of Pharmacology, National University of Singapore</institution>
, Singapore, 119077,
<country>Singapore</country>
</aff>
<aff id="a18">
<label>18</label>
<institution>MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</aff>
<aff id="a19">
<label>19</label>
<institution>Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht</institution>
, 3584 CX Utrecht,
<country>The Netherlands</country>
</aff>
<aff id="a20">
<label>20</label>
<institution>Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University</institution>
, Montreal, Quebec,
<country>Canada</country>
H3A 2B4</aff>
<aff id="a21">
<label>21</label>
<institution>The Royal College of Surgeons in Ireland</institution>
, 123 St Stephen's Green, Dublin 2,
<country>Ireland</country>
</aff>
<aff id="a22">
<label>22</label>
<institution>Department of Integrative Medical Biology and Umeå Center for Functional Brain Imaging, Umeå University</institution>
, 901 87 Umeå,
<country>Sweden</country>
</aff>
<aff id="a23">
<label>23</label>
<institution>Department of Biomedical Engineering, Illinois Institute of Technology</institution>
, Chicago, Illinois 60616,
<country>USA</country>
</aff>
<aff id="a24">
<label>24</label>
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, Illinois 60612,
<country>USA</country>
</aff>
<aff id="a25">
<label>25</label>
<institution>Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center</institution>
, Chicago, Illinois 60616,
<country>USA</country>
</aff>
<aff id="a26">
<label>26</label>
<institution>Brain Research Imaging Centre, University of Edinburgh</institution>
, Edinburgh EH4 2XU,
<country>UK</country>
</aff>
<aff id="a27">
<label>27</label>
<institution>Department of Computer Science, Lagos State University</institution>
, Lagos, P.M.B. 01 LASU,
<country>Nigeria</country>
</aff>
<aff id="a28">
<label>28</label>
<institution>Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</aff>
<aff id="a29">
<label>29</label>
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</aff>
<aff id="a30">
<label>30</label>
<institution>Mathematics and Statistics, Murdoch University</institution>
, Perth, Western Australia, 6150,
<country>Australia</country>
</aff>
<aff id="a31">
<label>31</label>
<institution>NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo</institution>
, 0315 Oslo,
<country>Norway</country>
</aff>
<aff id="a32">
<label>32</label>
<institution>NORMENT—KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital</institution>
, 0424 Oslo,
<country>Norway</country>
</aff>
<aff id="a33">
<label>33</label>
<institution>Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University</institution>
, Box 1432, SE-751 44 Uppsala,
<country>Sweden</country>
</aff>
<aff id="a34">
<label>34</label>
<institution>Dr John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</aff>
<aff id="a35">
<label>35</label>
<institution>John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</aff>
<aff id="a36">
<label>36</label>
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, Massachusetts,02118,
<country>USA</country>
</aff>
<aff id="a37">
<label>37</label>
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, Massachusetts 02118
<country>USA</country>
</aff>
<aff id="a38">
<label>38</label>
<institution>Framingham Heart Study</institution>
, 17 Mount Wayte Avenue, Framingham, Massachusetts 01703
<country>USA</country>
</aff>
<aff id="a39">
<label>39</label>
<institution>Hospital for Sick Children, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M5G 1X8</aff>
<aff id="a40">
<label>40</label>
<institution>Taub Institute for Research on Alzheimer's Disease and the Aging Brain; G.H. Sergievsky Center; Department of Neurology. Columbia University Medical Center</institution>
, 639 West 1168th Street, New York, New York 10032,
<country>USA</country>
</aff>
<aff id="a41">
<label>41</label>
<institution>Pennington Biomedical Research Center</institution>
, Baton Rouge, Louisiana 70808,
<country>USA</country>
</aff>
<aff id="a42">
<label>42</label>
<institution>Cerebral Imaging Centre, Douglas Mental Health University Institute</institution>
, Montreal, Quebec, Canada H4H 1R3</aff>
<aff id="a43">
<label>43</label>
<institution>Department of Psychiatry and Biomedical Engineering, McGill University</institution>
, Montreal, Quebec,
<country>Canada</country>
H3A 2B4</aff>
<aff id="a44">
<label>44</label>
<institution>Lieber Institute for Brain Development</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</aff>
<aff id="a45">
<label>45</label>
<institution>Interdepartmental Neuroscience Graduate Program, UCLA School of Medicine</institution>
, Los Angeles, California 90095,
<country>USA</country>
</aff>
<aff id="a46">
<label>46</label>
<institution>Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167—RID-AGE—Risk factors and molecular determinants of aging-related diseases</institution>
, F-59000 Lille,
<country>France</country>
</aff>
<aff id="a47">
<label>47</label>
<institution>IMN UMR5293, GIN, CNRS, CEA, University of Bordeaux</institution>
, 146 rue Léo Saignat, 33076 Bordeaux,
<country>France</country>
</aff>
<aff id="a48">
<label>48</label>
<institution>Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</aff>
<aff id="a49">
<label>49</label>
<institution>Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden</institution>
, 01307 Dresden,
<country>Germany</country>
</aff>
<aff id="a50">
<label>50</label>
<institution>Department of Psychiatry, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</aff>
<aff id="a51">
<label>51</label>
<institution>Martinos Center for Biomedical Imaging, Massachusetts General Hospital</institution>
, Charlestown, Massachusetts 02129,
<country>USA</country>
</aff>
<aff id="a52">
<label>52</label>
<institution>NORMENT—KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen</institution>
, 5021 Bergen,
<country>Norway</country>
</aff>
<aff id="a53">
<label>53</label>
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, 5021 Bergen,
<country>Norway</country>
</aff>
<aff id="a54">
<label>54</label>
<institution>Department of Neurology, Johns Hopkins University School of Medicine</institution>
, Baltimore, Maryland 21287,
<country>USA</country>
</aff>
<aff id="a55">
<label>55</label>
<institution>Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg</institution>
, 68159 Mannheim,
<country>Germany</country>
</aff>
<aff id="a56">
<label>56</label>
<institution>Department of Data Science, University of Mississippi Medical Center</institution>
, Jackson, Mississippi, 39216,
<country>USA</country>
</aff>
<aff id="a57">
<label>57</label>
<institution>Language and Genetics Department, Max Planck Institute for Psycholinguistics</institution>
, 6525 XD Nijmegen,
<country>The Netherlands</country>
</aff>
<aff id="a58">
<label>58</label>
<institution>International Max Planck Research School for Language Sciences</institution>
, 6525 XD Nijmegen,
<country>The Netherlands</country>
</aff>
<aff id="a59">
<label>59</label>
<institution>Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden</institution>
, 01307 Dresden,
<country>Germany</country>
</aff>
<aff id="a60">
<label>60</label>
<institution>Department of Research and Development, Diakonhjemmet Hospital</institution>
, 0319 Oslo,
<country>Norway</country>
</aff>
<aff id="a61">
<label>61</label>
<institution>Max Planck Institute of Psychiatry</institution>
, 80804 Munich,
<country>Germany</country>
</aff>
<aff id="a62">
<label>62</label>
<institution>Department of Psychology, Yale University</institution>
, New Haven, Connecticut 06520,
<country>USA</country>
</aff>
<aff id="a63">
<label>63</label>
<institution>Department of Psychiatry, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</aff>
<aff id="a64">
<label>64</label>
<institution>UCL Institute of Neurology, London, United Kingdom and Epilepsy Society</institution>
, Bucks, SL9 0RJ,
<country>UK</country>
</aff>
<aff id="a65">
<label>65</label>
<institution>Department of Medicine, Imperial College London</institution>
, London SW7 2AZ,
<country>UK</country>
</aff>
<aff id="a66">
<label>66</label>
<institution>Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</aff>
<aff id="a67">
<label>67</label>
<institution>Center for Computational Biology and Bioinformatics, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</aff>
<aff id="a68">
<label>68</label>
<institution>Indiana Alzheimer Disease Center, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</aff>
<aff id="a69">
<label>69</label>
<institution>Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University</institution>
, Heidelberg, 69120,
<country>Germany</country>
</aff>
<aff id="a70">
<label>70</label>
<institution>Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital</institution>
, Boston, Massachusetts 02114,
<country>USA</country>
</aff>
<aff id="a71">
<label>71</label>
<institution>Harvard Medical School</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</aff>
<aff id="a72">
<label>72</label>
<institution>Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard</institution>
, Boston, Massachusetts 02141,
<country>USA</country>
</aff>
<aff id="a73">
<label>73</label>
<institution>Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School</institution>
, Lexington, Massachusetts, 02421,
<country>USA</country>
</aff>
<aff id="a74">
<label>74</label>
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh</institution>
, Edinburgh EH8 9JZ,
<country>UK</country>
</aff>
<aff id="a75">
<label>75</label>
<institution>Donders Centre for Cognitive Neuroimaging, Radboud University</institution>
, Nijmegen, 6525 EN,
<country>The Netherlands</country>
</aff>
<aff id="a76">
<label>76</label>
<institution>Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology</institution>
, London WC1N 3BG,
<country>UK</country>
</aff>
<aff id="a77">
<label>77</label>
<institution>Department of Biomedicine, Aarhus University</institution>
, DK-8000 Aarhus,
<country>Denmark</country>
</aff>
<aff id="a78">
<label>78</label>
<institution>The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</institution>
, DK-8000 Aarhus and Copenhagen,
<country>Denmark</country>
</aff>
<aff id="a79">
<label>79</label>
<institution>Center for integrated Sequencing, iSEQ, Aarhus University</institution>
, DK-8000 Aarhus,
<country>Denmark</country>
</aff>
<aff id="a80">
<label>80</label>
<institution>Department of Psychiatry, Yale University</institution>
, New Haven, Connecticut 06511,
<country>USA</country>
</aff>
<aff id="a81">
<label>81</label>
<institution>Olin Neuropsychiatric Research Center</institution>
, Hartford, Connecticut 06114,
<country>USA</country>
</aff>
<aff id="a82">
<label>82</label>
<institution>Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest</institution>
, 1081 HL Amsterdam,
<country>The Netherlands</country>
</aff>
<aff id="a83">
<label>83</label>
<institution>Human Genetics Branch, National Institute of Mental Health Intramural Research Program</institution>
, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719,
<country>USA</country>
</aff>
<aff id="a84">
<label>84</label>
<institution>Department of Neurology, Department of Anesthesia/Critical Care Medicine, Department of Neurosurgery, Johns Hopkins</institution>
, USA600 N. Wolfe St, Baltimore, Maryland 21287,
<country>USA</country>
</aff>
<aff id="a85">
<label>85</label>
<institution>Center for Neurobehavioral Genetics, University of California</institution>
, Los Angeles, California 90095,
<country>USA</country>
</aff>
<aff id="a86">
<label>86</label>
<institution>Department of Clinical Neuropsychology, VU University Amsterdam</institution>
, Amsterdam, 1081 HV,
<country>The Netherlands</country>
</aff>
<aff id="a87">
<label>87</label>
<institution>Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh</institution>
, Edinburgh EH10 5HF,
<country>UK</country>
</aff>
<aff id="a88">
<label>88</label>
<institution>Division of Systems Neuroscience of Psychopathology, Translational Research Center, University Hospital of Psychiatry, University of Bern</institution>
, Bern, 3060,
<country>Switzerland</country>
</aff>
<aff id="a89">
<label>89</label>
<institution>Department of Medical and Molecular Genetics, King's College London</institution>
, London SE1 9RT,
<country>UK</country>
</aff>
<aff id="a90">
<label>90</label>
<institution>The Jenner Institute Laboratories, University of Oxford</institution>
, Oxford OX3 7DQ,
<country>UK</country>
</aff>
<aff id="a91">
<label>91</label>
<institution>Karakter Child and Adolescent Psychiatry University Center</institution>
, Nijmegen, 6525 GC,
<country>The Netherlands</country>
</aff>
<aff id="a92">
<label>92</label>
<institution>Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL</institution>
, 39008 Santander,
<country>Spain</country>
</aff>
<aff id="a93">
<label>93</label>
<institution>CIBERSAM (Centro Investigación Biomédica en Red Salud Mental)</institution>
, Santander, 39011,
<country>Spain</country>
</aff>
<aff id="a94">
<label>94</label>
<institution>Psychosis Research Group, Department of Psychiatry & Trinity Translational Medicine Institute, Trinity College</institution>
, Dublin, Dublin 2,
<country>Ireland</country>
</aff>
<aff id="a95">
<label>95</label>
<institution>Centre for Clinical Brain Sciences, University of Edinburgh</institution>
, Edinburgh EH16 4SB,
<country>UK</country>
</aff>
<aff id="a96">
<label>96</label>
<institution>Department of Neurology, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</aff>
<aff id="a97">
<label>97</label>
<institution>Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</aff>
<aff id="a98">
<label>98</label>
<institution>Orygen, The National Centre of Excellence in Youth Mental Health</institution>
, Melbourne, Victoria, 3502,
<country>Australia</country>
</aff>
<aff id="a99">
<label>99</label>
<institution>Centre for Youth Mental Health, The University of Melbourne</institution>
, Melbourne, Victoria, 3502,
<country>Australia</country>
</aff>
<aff id="a100">
<label>100</label>
<institution>Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center</institution>
, 1007 MB Amsterdam,
<country>The Netherlands</country>
</aff>
<aff id="a101">
<label>101</label>
<institution>Multimodal Imaging Laboratory, Department of Neurosciences, University of California</institution>
, San Diego, California 92093,
<country>USA</country>
</aff>
<aff id="a102">
<label>102</label>
<institution>Department of Cognitive Sciences, University of California</institution>
, San Diego, California 92161,
<country>USA</country>
</aff>
<aff id="a103">
<label>103</label>
<institution>Icelandic Heart Association</institution>
, Kopavogur, 201,
<country>Iceland</country>
</aff>
<aff id="a104">
<label>104</label>
<institution>Faculty of Medicine, University of Iceland</institution>
, Reykjavik, 101,
<country>Iceland</country>
</aff>
<aff id="a105">
<label>105</label>
<institution>Department of Psychiatry, Icahn School of Medicine at Mount Sinai</institution>
, New York, New York, 10029,
<country>USA</country>
</aff>
<aff id="a106">
<label>106</label>
<institution>Queensland Brain Institute, University of Queensland</institution>
, Brisbane, Queensland 4072,
<country>Australia</country>
</aff>
<aff id="a107">
<label>107</label>
<institution>Institute for Community Medicine, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</aff>
<aff id="a108">
<label>108</label>
<institution>Neuroimaging Unit, Technological Facilities. Valdecilla Biomedical Research Institute IDIVAL</institution>
, Santander, Cantabria, 39011,
<country>Spain</country>
</aff>
<aff id="a109">
<label>109</label>
<institution>Institut Pasteur</institution>
, 75015 Paris,
<country>France</country>
</aff>
<aff id="a110">
<label>110</label>
<institution>Department of Genetics, King Faisal Specialist Hospital and Research Centre</institution>
, Riyadh 11211,
<country>Saudi Arabia</country>
</aff>
<aff id="a111">
<label>111</label>
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden, 2300RC,
<country>The Netherlands</country>
</aff>
<aff id="a112">
<label>112</label>
<institution>GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine</institution>
, 1830 E Monument St Suite 8028, Baltimore, Maryland 21287,
<country>USA</country>
</aff>
<aff id="a113">
<label>113</label>
<institution>Department of Radiology, Leiden University Medical Center</institution>
, Leiden, 2300RC,
<country>The Netherlands</country>
</aff>
<aff id="a114">
<label>114</label>
<institution>Department of Psychiatry, University of Groningen, University Medical Center Groningen</institution>
, Groningen, 9700RB,
<country>The Netherlands</country>
</aff>
<aff id="a115">
<label>115</label>
<institution>Brain Center Rudolf Magnus, Human Neurogenetics Unit, UMC Utrecht</institution>
, 3584 CG Utrecht,
<country>The Netherlands</country>
</aff>
<aff id="a116">
<label>116</label>
<institution>Department of Psychiatry and Human Behavior, University of California-Irvine</institution>
, Irvine, California 92617,
<country>USA</country>
</aff>
<aff id="a117">
<label>117</label>
<institution>Department of Psychology, Georgia State University</institution>
, Atlanta, Georgia 30302,
<country>USA</country>
</aff>
<aff id="a118">
<label>118</label>
<institution>NORMENT—KG Jebsen Centre, Department of Psychology, University of Oslo</institution>
, 0317 Oslo,
<country>Norway</country>
</aff>
<aff id="a119">
<label>119</label>
<institution>Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, Mississippi, 39216,
<country>USA</country>
</aff>
<aff id="a120">
<label>120</label>
<institution>FMRIB Centre, University of Oxford</institution>
, Oxford OX3 9DU,
<country>UK</country>
</aff>
<aff id="a121">
<label>121</label>
<institution>German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald</institution>
, 17487 Greifswald,
<country>Germany</country>
</aff>
<aff id="a122">
<label>122</label>
<institution>University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy</institution>
, Wuerzburg, 97080,
<country>Germany</country>
</aff>
<aff id="a123">
<label>123</label>
<institution>Department of Neurological Sciences, Rush University Medical Center</institution>
, Chicago, Illinois 60612,
<country>USA</country>
</aff>
<aff id="a124">
<label>124</label>
<institution>Biospective Inc, Montreal, Quebec, Canada</institution>
, 6100 Avenue Royalmount, Montréal, Québec,
<country>Canada</country>
H4P 2R2</aff>
<aff id="a125">
<label>125</label>
<institution>Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet</institution>
, SE-171 77 Stockholm,
<country>Sweden</country>
</aff>
<aff id="a126">
<label>126</label>
<institution>South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine</institution>
, Brownsville/Edinburg/San Antonio, Texas, 78250,
<country>USA</country>
</aff>
<aff id="a127">
<label>127</label>
<institution>Department of Genetics, Perelman School of Medicine, University of Pennsylvania</institution>
, Philadelphia, Pennsylvania 19104,
<country>USA</country>
</aff>
<aff id="a128">
<label>128</label>
<institution>Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia</institution>
, Philadelphia, Pennsylvania 29104,
<country>USA</country>
</aff>
<aff id="a129">
<label>129</label>
<institution>National Ageing Research Institute, Royal Melbourne Hospital</institution>
, Melbourne, Victoria 3052,
<country>Australia</country>
</aff>
<aff id="a130">
<label>130</label>
<institution>Academic Unit for Psychiatry of Old Age, University of Melbourne</institution>
, Melbourne, Victoria 3101,
<country>Australia</country>
</aff>
<aff id="a131">
<label>131</label>
<institution>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health</institution>
, Bethesda, Maryland 20892,
<country>USA</country>
</aff>
<aff id="a132">
<label>132</label>
<institution>Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh</institution>
, 3501 Forbes Ave., Suite 830, Pittsburgh, Pennsylvania 15213,
<country>USA</country>
</aff>
<aff id="a133">
<label>133</label>
<institution>Dementia Collaborative Research Centre—Assessment and Better Care, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</aff>
<aff id="a134">
<label>134</label>
<institution>Department of Clinical Genetics and GROW School for Oncology and Developmental Biology, Maastricht University Medical Center</institution>
, 6200 MD Maastricht,
<country>The Netherlands</country>
</aff>
<aff id="a135">
<label>135</label>
<institution>Department of Psychology, Center for Brain Science, Harvard University</institution>
, Cambridge, Massachusetts 02138,
<country>USA</country>
</aff>
<aff id="a136">
<label>136</label>
<institution>Department of Evolution and Genetics, Dagestan State University</institution>
, Makhachkala 367000, Dagestan,
<country>Russia</country>
</aff>
<aff id="a137">
<label>137</label>
<institution>The Mind Research Network & LBERI</institution>
, Albuquerque, New Mexico 87106,
<country>USA</country>
</aff>
<aff id="a138">
<label>138</label>
<institution>Department of ECE, University of New Mexico</institution>
, Albuquerque, New Mexico 87131,
<country>USA</country>
</aff>
<aff id="a139">
<label>139</label>
<institution>Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway</institution>
, H91 TK33 Galway,
<country>Ireland</country>
</aff>
<aff id="a140">
<label>140</label>
<institution>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</institution>
, Singapore, 119077,
<country>Singapore</country>
</aff>
<aff id="a141">
<label>141</label>
<institution>Division of Medical Genetics, Department of Biomedicine, University of Basel</institution>
, 4031 Basel,
<country>Switzerland</country>
</aff>
<aff id="a142">
<label>142</label>
<institution>Institute of Human Genetics, University of Bonn</institution>
, 53127 Bonn,
<country>Germany</country>
</aff>
<aff id="a143">
<label>143</label>
<institution>Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich</institution>
, 52425 Jülich,
<country>Germany</country>
</aff>
<aff id="a144">
<label>144</label>
<institution>Center for Multimodal Imaging and Genetics, University of California</institution>
, San Diego, California 92093,
<country>USA</country>
</aff>
<aff id="a145">
<label>145</label>
<institution>Departments of Neurosciences, Radiology, Psychiatry, and Cognitive Science, University of California</institution>
, San Diego, California 92093,
<country>USA</country>
</aff>
<aff id="a146">
<label>146</label>
<institution>Avera Institute for Human Genetics</institution>
, Sioux Falls, South Dakota 57108,
<country>USA</country>
</aff>
<aff id="a147">
<label>147</label>
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden, 2300RC,
<country>The Netherlands</country>
</aff>
<aff id="a148">
<label>148</label>
<institution>Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Brigham and Women's Hospital</institution>
, Boston, Massachusetts, 02115,
<country>USA</country>
</aff>
<aff id="a149">
<label>149</label>
<institution>Harvard Medical School</institution>
, Boston, Massachusetts, 02115,
<country>USA</country>
</aff>
<aff id="a150">
<label>150</label>
<institution>Program in Medical and Population Genetics, Broad Institute</institution>
, Cambridge, Massachusetts, 02142,
<country>USA</country>
</aff>
<aff id="a151">
<label>151</label>
<institution>Broad Institute</institution>
, Cambridge, Massachusetts, 02142,
<country>USA</country>
</aff>
<aff id="a152">
<label>152</label>
<institution>Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT)</institution>
, Brisbane, Queensland 4059,
<country>Australia</country>
</aff>
<aff id="a153">
<label>153</label>
<institution>Department of Neurology, Bordeaux University Hospital</institution>
, Bordeaux, 33076,
<country>France</country>
</aff>
<aff id="a154">
<label>154</label>
<institution>Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis</institution>
, 4860 Y Street, Suite 3700, Sacramento, California 95817,
<country>USA</country>
</aff>
<aff id="a155">
<label>155</label>
<institution>Neurology Division, Beaumont Hospital</institution>
, Dublin 9,
<country>Ireland</country>
</aff>
<aff id="a156">
<label>156</label>
<institution>Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles</institution>
, 1070 Brussels,
<country>Belgium</country>
</aff>
<aff id="a157">
<label>157</label>
<institution>Department of Medical Genetics, Oslo University Hospital</institution>
, 0420 Oslo,
<country>Norway</country>
</aff>
<aff id="a158">
<label>158</label>
<institution>Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition & Genomics Centre (NICOG) & NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway</institution>
, H91 TK33, Galway,
<country>Ireland</country>
</aff>
<aff id="a159">
<label>159</label>
<institution>Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College Dublin</institution>
, Dublin 8,
<country>Ireland</country>
</aff>
<aff id="a160">
<label>160</label>
<institution>Janssen Research & Development, LLC</institution>
, Titusville, New Jersey 08560,
<country>USA</country>
</aff>
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<label>161</label>
<institution>Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Department of Psychiatry and Psychotherapy</institution>
, Charitéplatz 1, 10117 Berlin,
<country>Germany</country>
</aff>
<aff id="a162">
<label>162</label>
<institution>Intramural Research Program of the National Institute on Aging</institution>
, Baltimore, Maryland, 21224,
<country>USA</country>
</aff>
<aff id="a163">
<label>163</label>
<institution>Department of Neurological Sciences & Department of Behavioral Sciences, Rush University Medical Center</institution>
, Chicago, Illinois 60616,
<country>USA</country>
</aff>
<aff id="a164">
<label>164</label>
<institution>Robertson Centre for Biostatistics, University of Glasgow</institution>
, Glasgow, G41 4DQ,
<country>UK</country>
</aff>
<aff id="a165">
<label>165</label>
<institution>Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston</institution>
, Houston, Texas, 77030,
<country>USA</country>
</aff>
<aff id="a166">
<label>166</label>
<institution>Medical and Molecular Genetics, Indiana University School of Medicine</institution>
, Indianapolis, Indiana 46202,
<country>USA</country>
</aff>
<aff id="a167">
<label>167</label>
<institution>University of Texas Health Science Center</institution>
, San Antonio, Texas 78229,
<country>USA</country>
</aff>
<aff id="a168">
<label>168</label>
<institution>Division of Cerebral Integration, National Institute for Physiological Sciences</institution>
, Aichi, 444-8585,
<country>Japan</country>
</aff>
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<label>169</label>
<institution>Division of Genetics, Department of Medicine, Brigham and Women's Hospital</institution>
, Boston, Massachusetts 02115,
<country>USA</country>
</aff>
<aff id="a170">
<label>170</label>
<institution>Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU)</institution>
, Trondheim, 7491,
<country>Norway</country>
</aff>
<aff id="a171">
<label>171</label>
<institution>Department of Radiology, St. Olav's Hospital, Trondheim University Hospital</institution>
, Trondheim, 7030,
<country>Norway</country>
</aff>
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<label>172</label>
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, Osaka 565-0871,
<country>Japan</country>
</aff>
<aff id="a173">
<label>173</label>
<institution>Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University</institution>
, Osaka, 565-0871,
<country>Japan</country>
</aff>
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<label>174</label>
<institution>Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</aff>
<aff id="a175">
<label>175</label>
<institution>German Center for Neurodegenerative Diseases (DZNE)</institution>
, Tübingen, 72076,
<country>Germany</country>
</aff>
<aff id="a176">
<label>176</label>
<institution>Department of Psychology, VU University Amsterdam</institution>
, 1081 BT Amsterdam,
<country>The Netherlands</country>
</aff>
<aff id="a177">
<label>177</label>
<institution>Department of Psychiatry, University of Iowa</institution>
, Iowa City, Iowa 52242,
<country>USA</country>
</aff>
<aff id="a178">
<label>178</label>
<institution>Department of Epidemiology, Harvard T.H. Chan School of Public Health</institution>
, Boston, Massachusetts 02115
<country>USA</country>
</aff>
<aff id="a179">
<label>179</label>
<institution>HMNC Brain Health</institution>
, Munich, 80539,
<country>Germany</country>
</aff>
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<label>180</label>
<institution>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald</institution>
, 17489 Greifswald,
<country>Germany</country>
</aff>
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, 445N Fifth Street, Phoenix, Arizona 85004,
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</aff>
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<label>182</label>
<institution>Department of Psychiatry, Fujita Health University School of Medicine</institution>
, Toyoake 470-1192,
<country>Japan</country>
</aff>
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<label>183</label>
<institution>Department of Radiology, Mayo Clinic</institution>
, Rochester, Minnesota 55905,
<country>USA</country>
</aff>
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<label>184</label>
<institution>NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School</institution>
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<label>185</label>
<institution>School of Psychology, University of Sussex</institution>
, Brighton BN1 9QH,
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<label>186</label>
<institution>Institute of Cognitive Neuroscience, University College London</institution>
, London WC1N 3AR,
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</aff>
<aff id="a187">
<label>187</label>
<institution>Department of Neuroinformatics, Araya Brain Imaging</institution>
, Tokyo, 102-0093,
<country>Japan</country>
</aff>
<aff id="a188">
<label>188</label>
<institution>Medical University of Lodz</institution>
, 90-419 Lodz,
<country>Poland</country>
</aff>
<aff id="a189">
<label>189</label>
<institution>Department of Neurology, Mayo Clinic</institution>
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</aff>
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<label>190</label>
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</aff>
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<label>191</label>
<institution>Neuroscience Research Australia</institution>
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</aff>
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<label>193</label>
<institution>INSERM UMR 1000 “Neuroimaging and Psychiatry”, Service Hospitalier Frédéric Joliot; University Paris-Sud, Université Paris-Saclay, University Paris Descartes</institution>
, Maison de Solenn, Paris, 91400,
<country>France</country>
</aff>
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<label>194</label>
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, 3501 Forbes Ave., Suite 830, Pittsburgh Pennsylvania 15213,
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</aff>
<aff id="a197">
<label>197</label>
<institution>Department of Psychiatry, University of Oxford</institution>
, Oxford OX3 7JX,
<country>UK</country>
</aff>
<aff id="a198">
<label>198</label>
<institution>Department of Radiology, Johns Hopkins University School of Medicine</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</aff>
<aff id="a199">
<label>199</label>
<institution>Centre for Advanced Imaging, University of Queensland</institution>
, Brisbane, Queensland 4072,
<country>Australia</country>
</aff>
<aff id="a200">
<label>200</label>
<institution>Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia</institution>
, 06132 Perugia,
<country>Italy</country>
</aff>
<aff id="a201">
<label>201</label>
<institution>Munich Cluster for Systems Neurology (SyNergy)</institution>
, 81377 Munich,
<country>Germany</country>
</aff>
<aff id="a202">
<label>202</label>
<institution>University of Liverpool, Institute of Translational Medicine</institution>
, Liverpool L69 3BX,
<country>UK</country>
</aff>
<aff id="a203">
<label>203</label>
<institution>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald</institution>
, 17489 Greifswald,
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</aff>
<aff id="a204">
<label>204</label>
<institution>German Center for Cardiovascular Research (DZHK e.V.), partner site Greifswald</institution>
, Greifswald, 17475,
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</aff>
<aff id="a205">
<label>205</label>
<institution>Department of Statistics & WMG, University of Warwick</institution>
, Coventry CV4 7AL,
<country>UK</country>
</aff>
<aff id="a206">
<label>206</label>
<institution>Department of Medical Informatics Erasmus MC</institution>
, 3015 CE Rotterdam,
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</aff>
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<label>207</label>
<institution>Faculty of Applied Sciences, Delft University of Technology</institution>
, Delft, 2628 CD,
<country>The Netherlands</country>
</aff>
<aff id="a208">
<label>208</label>
<institution>Department of Genomics, Life & Brain Center, University of Bonn</institution>
, 53127 Bonn,
<country>Germany</country>
</aff>
<aff id="a209">
<label>209</label>
<institution>Rotman Research Institute, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M6A 2E1</aff>
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<label>210</label>
<institution>Departments of Psychology and Psychiatry, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M5T 1R8</aff>
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<label>211</label>
<institution>Child Mind Institute</institution>
, New York, New York, 10022,
<country>USA</country>
</aff>
<aff id="a212">
<label>212</label>
<institution>Departments of Physiology and Nutritional Sciences, University of Toronto</institution>
, Toronto, Ontario,
<country>Canada</country>
M5S 3E2</aff>
<aff id="a213">
<label>213</label>
<institution>Department of Radiology, University of Calgary</institution>
, Calgary, Alberta,
<country>Canada</country>
T2N 4N1</aff>
<aff id="a214">
<label>214</label>
<institution>Department of Clinical Neuroscience, University of Calgary</institution>
, Calgary, Alberta,
<country>Canada</country>
T2N 4N1</aff>
<aff id="a215">
<label>215</label>
<institution>Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, USA Group Health Research Institute, Group Health</institution>
, 1730 Minor Avenue/Suite 1360, Seattle, Washington 98101,
<country>USA</country>
</aff>
<aff id="a216">
<label>216</label>
<institution>Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales</institution>
, Sydney, New South Wales 2052,
<country>Australia</country>
</aff>
<aff id="a217">
<label>217</label>
<institution>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center</institution>
, Torrance, California 90502,
<country>USA</country>
</aff>
<aff id="a218">
<label>218</label>
<institution>Evelyn F. McKnight Brain Institute, University of Miami, Miller School of Medicine</institution>
, Miami, Florida, 33136,
<country>USA</country>
</aff>
<aff id="a219">
<label>219</label>
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Randwick, New South Wales 2031,
<country>Australia</country>
</aff>
<aff id="a220">
<label>220</label>
<institution>Institute of Molecular Biology and Biochemistry, Medical University Graz</institution>
, Harrachgasse 21/III, 8010 Graz,
<country>Austria</country>
</aff>
<aff id="a221">
<label>221</label>
<institution>Department of Neuroimaging, Institute of Psychiatry, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</aff>
<aff id="a222">
<label>222</label>
<institution>Biomedical Research Centre for Mental Health, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</aff>
<aff id="a223">
<label>223</label>
<institution>Biomedical Research Unit for Dementia, King's College London</institution>
, London SE5 8AF,
<country>UK</country>
</aff>
<aff id="a224">
<label>224</label>
<institution>MRC Edinburgh Brain Bank, University of Edinburgh, Academic Department of Neuropathology, Centre for Clinical Brain Sciences</institution>
, Edinburgh, EH16 4SB
<country>UK</country>
</aff>
<aff id="a225">
<label>225</label>
<institution>Institute of Clinical Medicine, Neurology, University of Eastern Finland</institution>
, FI-70211 Kuopio,
<country>Finland</country>
</aff>
<aff id="a226">
<label>226</label>
<institution>Neurocentre Neurology, Kuopio University Hospital</institution>
, FI-70211 Kuopio,
<country>Finland</country>
</aff>
<aff id="a227">
<label>227</label>
<institution>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow</institution>
, Glasgow, G4 0SF,
<country>UK</country>
</aff>
<aff id="a228">
<label>228</label>
<institution>Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine of the University of Southern California</institution>
, Los Angeles, California 90033,
<country>USA</country>
</aff>
<aff id="a229">
<label>229</label>
<institution>Department of Pathology, Johns Hopkins University</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</aff>
<aff id="a230">
<label>230</label>
<institution>3rd Department of Neurology, "G. Papanicolaou", Hospital, Aristotle University of Thessaloniki</institution>
, Thessaloniki, 57010,
<country>Greece</country>
</aff>
<aff id="a231">
<label>231</label>
<institution>Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR1219</institution>
, Bordeaux, F-33000,
<country>France</country>
</aff>
<aff id="a232">
<label>232</label>
<institution>Department of Internal Medicine, Erasmus MC</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</aff>
<aff id="a233">
<label>233</label>
<institution>Genentech Inc.</institution>
, South San Francisco, California 94080,
<country>USA</country>
</aff>
<aff id="a234">
<label>234</label>
<institution>Department of Psychiatry and Leiden Institute for Brain and Cognition, Leiden University Medical Center</institution>
, 2333 ZA Leiden,
<country>The Netherlands</country>
</aff>
<aff id="a235">
<label>235</label>
<institution>University of Groningen, University Medical Center Groningen, Department of Neuroscience</institution>
, 9713 AW Groningen,
<country>the Netherlands</country>
</aff>
<aff id="a236">
<label>236</label>
<institution>Department of Internal Medicine and Geriatric Medicine, INSERM U1027, University of Toulouse</institution>
, Toulouse, 31024,
<country>France</country>
</aff>
<aff id="a237">
<label>237</label>
<institution>Department of Psychiatry, Carver College of Medicine, University of Iowa</institution>
, Iowa City, Iowa 52242,
<country>USA</country>
</aff>
<aff id="a238">
<label>238</label>
<institution>Departments of Psychiatry, Neurology, Neuroscience and the Institute of Genetic Medicine, Johns Hopkins University School of Medicine</institution>
, Baltimore, Maryland 21205,
<country>USA</country>
</aff>
<aff id="a239">
<label>239</label>
<institution>Center for Imaging of Neurodegenerative Disease, San Francisco VA Medical Center, University of California</institution>
, San Francisco, California 94121,
<country>USA</country>
</aff>
<aff id="a240">
<label>240</label>
<institution>Department of Neurobiology, Care Sciences and Society, Karolinska Institutet</institution>
, SE-141 57 Huddinge,
<country>Sweden</country>
</aff>
<aff id="a241">
<label>241</label>
<institution>Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital</institution>
, 3015 CE Rotterdam,
<country>The Netherlands</country>
</aff>
<aff id="a242">
<label>242</label>
<institution>Laboratory of Epidemiology & Population Sciences, National Institute on Aging, National Institutes of Health</institution>
, Bethesda, Maryland 20892,
<country>USA</country>
</aff>
<aff id="a243">
<label>243</label>
<institution>Departments of Neurology and Epidemiology, University of Washington</institution>
, 325 Ninth Avenue, Seattle, Washington 98104-2420,
<country>USA</country>
</aff>
<aff id="a244">
<label>244</label>
<institution>Intramural Research Program, NIA, NIH</institution>
, 7201 Wisconsin Ave, Suite 3C-309, Bethesda, Maryland 20892,
<country>USA</country>
</aff>
<aff id="a245">
<label>245</label>
<institution>Department of Neurology, Erasmus MC</institution>
, Rotterdam 3015 CE,
<country>The Netherlands</country>
</aff>
</contrib-group>
<author-notes>
<corresp id="c1">
<label>a</label>
<email>pthomp@usc.edu</email>
</corresp>
<corresp id="c2">
<label>b</label>
<email>m.a.ikram@erasmusmc.nl</email>
</corresp>
<fn id="n1">
<label>*</label>
<p>These authors contributed equally to this work.</p>
</fn>
<fn id="n2">
<label>†</label>
<p>These authors jointly supervised the study</p>
</fn>
</author-notes>
<pub-date pub-type="epub">
<day>18</day>
<month>01</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="collection">
<year>2017</year>
</pub-date>
<volume>8</volume>
<elocation-id>13624</elocation-id>
<history>
<date date-type="received">
<day>23</day>
<month>08</month>
<year>2016</year>
</date>
<date date-type="accepted">
<day>18</day>
<month>10</month>
<year>2016</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright © 2017, The Author(s)</copyright-statement>
<copyright-year>2017</copyright-year>
<copyright-holder>The Author(s)</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
<pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
</license-p>
</license>
</permissions>
<abstract>
<p>The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (
<italic>ASTN2</italic>
,
<italic>DPP4</italic>
and
<italic>MAST4</italic>
) and one is found 200 kb upstream of
<italic>SHH</italic>
. A hippocampal subfield analysis shows that a locus within the
<italic>MSRB3</italic>
gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (
<italic>r</italic>
<sub>g</sub>
=−0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.</p>
</abstract>
<abstract abstract-type="web-summary">
<p>The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.</p>
</abstract>
</article-meta>
</front>
<body>
<p>Brain structural abnormalities in the hippocampal formation are found in many complex neurological and psychiatric disorders including temporal lobe epilepsy
<xref ref-type="bibr" rid="b1">1</xref>
, vascular dementia
<xref ref-type="bibr" rid="b2">2</xref>
, Alzheimer's disease
<xref ref-type="bibr" rid="b3">3</xref>
, major depression
<xref ref-type="bibr" rid="b4">4</xref>
, bipolar disorder
<xref ref-type="bibr" rid="b5">5</xref>
, schizophrenia
<xref ref-type="bibr" rid="b6">6</xref>
and post-traumatic stress disorder
<xref ref-type="bibr" rid="b7">7</xref>
, among others. The diverse functions of the hippocampus, including episodic memory
<xref ref-type="bibr" rid="b8">8</xref>
, spatial navigation
<xref ref-type="bibr" rid="b9">9</xref>
, cognition
<xref ref-type="bibr" rid="b10">10</xref>
and stress responsiveness
<xref ref-type="bibr" rid="b11">11</xref>
are commonly impaired in a broad range of diseases and disorders of the brain that are associated with insults to the hippocampal structure. Further, the cytoarchitectural subdivisions (or ‘subfields') of the hippocampus are associated with distinct functions. For example, the dentate gyrus (DG) and sectors 3 and 4 of the cornu ammonis (CA) are involved in declarative memory acquisition
<xref ref-type="bibr" rid="b12">12</xref>
, the subiculum and CA1 play a role in disambiguation during working memory processes
<xref ref-type="bibr" rid="b13">13</xref>
, and the CA2 is implicated in animal models of episodic time encoding
<xref ref-type="bibr" rid="b14">14</xref>
and social memory
<xref ref-type="bibr" rid="b15">15</xref>
. The anterior hippocampus, which includes the fimbria, CA subregions and hippocampal -amygdaloid transition area (HATA), may be involved in the mediation of cognitive processes including imagination, recall and visual perception
<xref ref-type="bibr" rid="b16">16</xref>
and anxiety-related behaviours
<xref ref-type="bibr" rid="b17">17</xref>
.</p>
<p>Environmental factors, such as stress, affect the hippocampus
<xref ref-type="bibr" rid="b18">18</xref>
, but genetic differences across individuals account for most of the population variation in its size; the heritability of hippocampal volume is high at around 70% (refs
<xref ref-type="bibr" rid="b19">19</xref>
,
<xref ref-type="bibr" rid="b20">20</xref>
,
<xref ref-type="bibr" rid="b21">21</xref>
). High heritability and a crucial role in healthy and diseased brain function make the hippocampus an ideal target for genetic analysis. We formed a large global partnership to empower the quest for mechanistic insights into neuropsychiatric disorders associated with hippocampal abnormalities and to chart, in depth, the genetic underpinnings of the hippocampal structure.</p>
<p>Here we perform a GWAS meta-analysis of mean bilateral hippocampal volume in 33,536 individuals scanned at 65 sites around the world as a joint effort between the Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) and the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortia. Our primary goal is to find common genetic determinants of hippocampal volume with previously unobtainable power. We make considerable efforts to coordinate data analysis across all sites from both consortia to maximize the comparability of both genetic and imaging data. Standardized protocols for image analysis and genetic imputation are freely available online (see URLs). In the most powerful imaging study of the hippocampus to date, we shed light on the common genetic determinants of hippocampal structure and allow for a deepened understanding of the biological workings of the brain's memory centre. We confirm previously identified loci influencing hippocampal volume, identify four novel loci and determine genome-wide overlap with Alzheimer's disease.</p>
<sec disp-level="1">
<title>Results</title>
<sec disp-level="2">
<title>Novel genome-wide markers associated with hippocampal volume</title>
<p>Our combined meta-analysis (
<italic>n</italic>
=26,814 individuals of European ancestry) revealed six independent, genome-wide significant loci associated with hippocampal volume (
<xref ref-type="fig" rid="f1">Fig. 1</xref>
;
<xref ref-type="table" rid="t1">Table 1</xref>
). Four are novel: with index SNPs rs11979341 (7q36.3;
<italic>P</italic>
=1.42 × 10
<sup>−11</sup>
), rs7020341 (9q33.1;
<italic>P</italic>
=3.04 × 10
<sup>−11</sup>
), rs2268894 (2q24.2;
<italic>P</italic>
=5.89 × 10
<sup>−11</sup>
), and rs2289881 (5q12.3;
<italic>P</italic>
=2.73 × 10
<sup>−8</sup>
). The other two loci have been previously characterized in detail: with index SNPs rs77956314 (12q24.22,
<italic>P</italic>
=2.06 × 10
<sup>−25</sup>
), in linkage disequilibrium (LD) (
<italic>r</italic>
<sup>2</sup>
=0.901 in European samples from the 1000 Genomes Project, Phase 1v3) with our previously identified variant at this locus (rs7294919) and rs61921502 (12q14.3,
<italic>P</italic>
=1.94 × 10
<sup>−19</sup>
), in LD (
<italic>r</italic>
<sup>2</sup>
=0.459) with previous top locus rs17178006 (refs
<xref ref-type="bibr" rid="b22">22</xref>
,
<xref ref-type="bibr" rid="b23">23</xref>
,
<xref ref-type="bibr" rid="b24">24</xref>
;
<xref ref-type="fig" rid="f2">Fig. 2a–f</xref>
). In addition to these SNPs, we identified nine independent loci with a statistically suggestive influence on hippocampal volume (
<italic>P</italic>
<1 × 10
<sup>−6</sup>
;
<xref ref-type="supplementary-material" rid="S1">Supplementary Data 4</xref>
). All pathway results and gene-based
<italic>P</italic>
values are summarized in
<xref ref-type="supplementary-material" rid="S1">Supplementary Data 6 and 7</xref>
.</p>
</sec>
<sec disp-level="2">
<title>Variance explained in hippocampal volume by common variants</title>
<p>Common variants genotyped from across the whole-genome explained as much as 18.76% (s.e. 1.56%) of the observed variance in human hippocampal volume, based on LDSCORE regression
<xref ref-type="bibr" rid="b25">25</xref>
(
<xref ref-type="supplementary-material" rid="S1">Supplementary Fig. 3</xref>
). Common genetic variants account for around a quarter of the overall heritability, estimated in twin studies to be around 70% (refs
<xref ref-type="bibr" rid="b19">19</xref>
,
<xref ref-type="bibr" rid="b20">20</xref>
,
<xref ref-type="bibr" rid="b21">21</xref>
). Further partitioning the genome into functional categories using LDSCORE
<xref ref-type="bibr" rid="b26">26</xref>
revealed significant over-representation of regions evolutionarily conserved in mammals (
<italic>P</italic>
=0.0026): 2.6% of the variants accounted for 43.3% of the 18.76% variance explained (
<xref ref-type="fig" rid="f3">Fig. 3</xref>
).</p>
</sec>
<sec disp-level="2">
<title>Effects of top variants on hippocampal subfield volume</title>
<p>To test for differential effects on individual subfields of the hippocampal formation, we examined the six significant variants influencing whole hippocampal volume in a large cohort (
<italic>n</italic>
=5,368). We found that the top SNP from our primary analysis, rs77956314, has a broad, nonspecific effect on hippocampal subfield volumes with the greatest effect in the right hippocampal tail (
<italic>P</italic>
=1.27 × 10
<sup>−8</sup>
). rs61921502 showed strong lateral effects across right hippocampal subfields with the largest effect in the right hippocampal fissure (
<italic>P</italic>
=6.45 × 10
<sup>−9</sup>
). rs7020341 showed greatest effects bilaterally in the subiculum (left:
<italic>P</italic>
=1.59 × 10
<sup>−8</sup>
; right:
<italic>P</italic>
=1.42 × 10
<sup>−8</sup>
). rs2268894 show left-lateralized effects across hippocampal subfields with the strongest effect in the left hippocampal tail (
<italic>P</italic>
=1.76 × 10
<sup>−5</sup>
). The remaining two variants (rs11979341 and rs2289881) did not show significant evidence of association across any of the hippocampal subfields. The full set of results from the hippocampal subfield analysis is tabulated in
<xref ref-type="supplementary-material" rid="S1">Supplementary Data 8</xref>
.</p>
</sec>
<sec disp-level="2">
<title>Genetic overlap with hippocampal volume</title>
<p>We used LDSCORE
<xref ref-type="bibr" rid="b27">27</xref>
regression to quantify the degree of common genetic overlap between variants influencing the hippocampus and those influencing Alzheimer's disease. We found significant evidence of a moderate, negative relationship whereby variants associated with a decrease in hippocampal volume are associated with an increased risk for Alzheimer's disease (
<italic>r</italic>
<sub>g</sub>
=−0.155 (s.e. 0.0529),
<italic>P</italic>
=0.0034; see Methods).</p>
</sec>
</sec>
<sec disp-level="1">
<title>Discussion</title>
<p>We identified six genome-wide significant, independent loci associated with hippocampal volume in 26,814 subjects of European ancestry. Of the six loci, four were novel: rs11979341 (7q36.3;
<italic>P</italic>
=1.42 × 10
<sup>−11</sup>
), rs7020341 (9q33.1;
<italic>P</italic>
=3.04 × 10
<sup>−11</sup>
), rs2268894 (2q24.2;
<italic>P</italic>
=5.89 × 10
<sup>−11</sup>
) and rs2289881 (5q12.3;
<italic>P</italic>
=2.73 × 10
<sup>−8</sup>
). We previously discovered two of the novel loci, rs7020341 and rs2268894 (ref.
<xref ref-type="bibr" rid="b24">24</xref>
), but in this higher-powered analysis they now surpassed the genome-wide significance. In addition to the four novel loci, we replicated two loci associated with hippocampal volume: rs7492919 and rs17178006 (refs
<xref ref-type="bibr" rid="b23">23</xref>
,
<xref ref-type="bibr" rid="b24">24</xref>
). Hibar
<italic>et al</italic>
.
<xref ref-type="bibr" rid="b22">22</xref>
previously reported additional support for the rs17178006 association with hippocampal volume.</p>
<p>Each novel locus identified has unique functions and has previously been linked to diseases of the brain. Variant rs7020341 lies within an intron of the
<italic>astrotactin 2</italic>
(
<italic>ASTN2</italic>
) gene (
<xref ref-type="fig" rid="f2">Fig. 2d</xref>
) which encodes for a protein involved in glial-mediated neuronal migration in the developing brain
<xref ref-type="bibr" rid="b28">28</xref>
. Rare deletions overlapping this locus near the 3′ end of
<italic>ASTN2</italic>
have been observed in patients with autism spectrum disorder and attention-deficit/hyperactivity disorder
<xref ref-type="bibr" rid="b29">29</xref>
. Common variants near this site are associated with autism spectrum disorders
<xref ref-type="bibr" rid="b29">29</xref>
and migraine
<xref ref-type="bibr" rid="b30">30</xref>
. Variant rs2268894 is located in an intron of
<italic>DPP4</italic>
(
<xref ref-type="fig" rid="f2">Fig. 2e</xref>
) that encodes dipeptidyl peptidase IV; an enzyme regulating response to the ingestion of food
<xref ref-type="bibr" rid="b31">31</xref>
, and an established target of a treatment for type 2 diabetes mellitus (vildagliptin)
<xref ref-type="bibr" rid="b32">32</xref>
. In addition, rs2268894 is in strong LD (
<italic>r</italic>
<sup>2</sup>
=0.83) with a genome-wide significant locus associated with a decreased risk for schizophrenia (rs2909457)
<xref ref-type="bibr" rid="b33">33</xref>
; however, the allele that increases risk for schizophrenia also increases hippocampal volume even though patients with schizophrenia show decreased hippocampal volume relative to controls
<xref ref-type="bibr" rid="b6">6</xref>
. Variant rs11979341 lies in an intergenic region (
<xref ref-type="fig" rid="f2">Fig. 2c</xref>
) around 200 kb upstream of the
<italic>sonic hedgehog</italic>
(
<italic>SHH</italic>
) gene, crucial for neural tube formation
<xref ref-type="bibr" rid="b34">34</xref>
. Adult brain expression data provide some evidence that rs11979341-C increases the expression of
<italic>SHH</italic>
in adult human hippocampus
<xref ref-type="bibr" rid="b35">35</xref>
(
<italic>P</italic>
=0.0089). Finally, variant rs2289881 lies within an intron of the microtubule-associated serine/threonine kinase family member 4 (
<italic>MAST4</italic>
) gene (
<xref ref-type="fig" rid="f2">Fig. 2f</xref>
). The protein product of
<italic>MAST4</italic>
modulates the microtubule scaffolding; the gene has been linked to susceptibility for atherosclerosis in HIV-infected men
<xref ref-type="bibr" rid="b36">36</xref>
, and atypical frontotemporal dementia
<xref ref-type="bibr" rid="b37">37</xref>
.</p>
<p>Effect sizes from the full sample were almost identical to those obtained from a subset meta-analysis (Pearson's
<italic>r</italic>
<sup>2</sup>
>0.99;
<italic>n</italic>
=22,761) that removed all patients diagnosed with a neuropsychiatric disorder. Observed effects are therefore not likely to be driven by inclusion of patients with brain disorders. All significant loci are tabulated in
<xref ref-type="table" rid="t1">Table 1</xref>
. We found little evidence that these effects could be generalized to populations of African, Japanese, and Mexican-American ancestry, which could be due to the limited power from smaller non-European sample sizes available (
<italic>n</italic>
=6,722;
<xref ref-type="supplementary-material" rid="S1">Supplementary Data 5</xref>
).</p>
<p>We estimated that 18.76% (s.e. 1.56%) of the variance in hippocampal volume could be explained by genotyped common genetic variation. This effect was only tested within populations of European ancestry and does not necessarily reflect the level of explained variance in other populations worldwide. This is a substantial fraction of the overall genetic component of variance determined by twin heritability studies, and the heritability of hippocampal volume is relatively high at around 70% (refs
<xref ref-type="bibr" rid="b19">19</xref>
,
<xref ref-type="bibr" rid="b20">20</xref>
,
<xref ref-type="bibr" rid="b21">21</xref>
). With the same LDSCORE method, we estimated the amount of variance explained by common gene variants belonging to known functional cell categories
<xref ref-type="bibr" rid="b26">26</xref>
. We discovered enrichment of genomic regions conserved across mammals, which may have a strong evolutionary role in the hippocampal formation, a structure much more extensively developed in mammals than in other vertebrates
<xref ref-type="bibr" rid="b38">38</xref>
. Given that hippocampal atrophy is a hallmark of Alzheimer's disease pathology
<xref ref-type="bibr" rid="b39">39</xref>
, we were motivated to examine common genetic overlap between hippocampal volume and Alzheimer's disease risk. We found a significant negative relationship (
<italic>r</italic>
<sub>g</sub>
=−0.155 (s.e. 0.0529),
<italic>P</italic>
=0.0034), through which loci associated with decreased hippocampal volume also increase risk for AD. This confirms a shared etiological component between AD and hippocampal volume whereby genetic variants influencing hippocampal volume also modify the risk for developing AD.</p>
<p>As the hippocampal formation is a complex structure comprised of diverse functional units, we sought to examine the genetic variants identified in our analysis for focal effects on hippocampal subfield volumes. When assessing 13 subfields of the hippocampus (26 total, left and right) we found that two of the top variants from our analysis (rs77956314 and rs7020341) had largely non-specific effects: most of the subfield volumes showed significant evidence of association (
<xref ref-type="supplementary-material" rid="S1">Supplementary Data 8</xref>
). The variant rs61921502 showed a lateralized effect across the body of the right hippocampal formation, which includes the DG, subiculum, CA1 and fissure. Volume losses are frequently observed across the hippocampal body in AD
<xref ref-type="bibr" rid="b40">40</xref>
, major depression
<xref ref-type="bibr" rid="b41">41</xref>
, bipolar disorder
<xref ref-type="bibr" rid="b42">42</xref>
and temporal lobe epilepsy
<xref ref-type="bibr" rid="b43">43</xref>
. Prior pathway analyses have implicated the rs61921502 with
<italic>MSR3B</italic>
, a gene related to oxidative stress
<xref ref-type="bibr" rid="b24">24</xref>
. Genetic variation at
<italic>MSR3B</italic>
may influence neurogenesis specifically within the dentate regions of the hippocampal body, where cell proliferation is known to continue into adulthood in healthy humans
<xref ref-type="bibr" rid="b44">44</xref>
. However, further functional validation is required to test this hypothesis. Finally, the variant rs2268894 was associated with volume differences in the left hippocampal tail, a subfield that has previously shown shape abnormalities
<xref ref-type="bibr" rid="b45">45</xref>
and volume differences
<xref ref-type="bibr" rid="b46">46</xref>
in schizophrenia.</p>
<p>Here we identified four novel loci associated with hippocampal volume and examined each variant for localized effects in hippocampal subfields. When partitioning the full genome-wide association results into functionally annotated categories, we discovered that SNPs in evolutionarily conserved regions were significantly over-represented in their contribution to hippocampal volume. Further, we found significant evidence of shared genetic overlap between hippocampal volume and Alzheimer's disease. This large international effort shows that by mapping out the genetic influences on brain structure, we may begin to derive mechanistic hypotheses for brain regions causally implicated in the risk for neuropsychiatric disorders.</p>
</sec>
<sec disp-level="1">
<title>Methods</title>
<sec disp-level="2">
<title>Subjects and sites</title>
<p>High-resolution MRI brain scans and genome-wide genotyping data were available for 33,536 individuals from 65 sites in two large consortia: the ENIGMA Consortium and the CHARGE Consortium. Full details and demographics for each participating cohort are given in
<xref ref-type="supplementary-material" rid="S1">Supplementary Data 1</xref>
. All participants (or their legal representatives) provided written informed consent. The institutional review board of the University of Southern California and the local ethics board of Erasmus MC University Medical Center approved this study.</p>
</sec>
<sec disp-level="2">
<title>Imaging analysis and quality control</title>
<p>Hippocampal volumes were estimated using the automated and previously validated segmentation algorithms, FSL FIRST
<xref ref-type="bibr" rid="b47">47</xref>
from the FMRIB Software Library (FSL) and FreeSurfer
<xref ref-type="bibr" rid="b48">48</xref>
. Hippocampal segmentations were visually examined at each site, and poorly segmented scans were excluded. Sites also generated histogram plots to identify any volume outliers. Individuals with a volume more than three standard deviations away from the mean were visually inspected to verify proper segmentation. Statistical outliers were included in analysis if they were properly segmented; otherwise, they were removed. Average bilateral hippocampal volume was highly correlated across automated procedures used to measure it (Pearson's
<italic>r</italic>
=0.74)
<xref ref-type="bibr" rid="b22">22</xref>
. A measure of head size—intracranial volume (ICV)—was used as a covariate in these analyses to adjust for volumetric differences due to differences in head size alone. Most sites measured ICV for each participant using the inverse of the determinant of the transformation matrix required to register the subject's MRI scan to a common template and then multiplied by the template volume (1,948,105 mm
<sup>3</sup>
). Full details of image acquisition and processing performed at each site are given in
<xref ref-type="supplementary-material" rid="S1">Supplementary Data 2</xref>
.</p>
</sec>
<sec disp-level="2">
<title>Genetic imputation and quality control</title>
<p>Genetic data were obtained at each site using commercially available genotyping platforms. Before imputation, genetic homogeneity was assessed in each sample using multi-dimensional scaling (MDS). Ancestry outliers were excluded by visual inspection of the first two components. The primary analysis and all data presented in this main text were derived from subjects with European ancestry. Replication attempts in subjects of additional ancestries are presented in
<xref ref-type="supplementary-material" rid="S1">Supplementary Data 5</xref>
. Data were further cleaned and filtered to remove single-nucleotide polymorphisms (SNPs) with low minor allele frequency (MAF<0.01), deviations from Hardy–Weinberg Equilibrium (HWE;
<italic>P</italic>
<1 × 10
<sup>−6</sup>
), and poor genotyping call rate (<95%). Cleaned and filtered datasets were imputed to the 1000 Genomes Project reference panel (phase 1, version 3) using freely available and validated imputation software (MaCH/minimac, IMPUTE2, BEAGLE, GenABLE). After imputation, genetic data were further quality checked to remove poorly imputed SNPs (estimated
<italic>R</italic>
<sup>2</sup>
<0.5) or low MAF (<0.5%). Details on filtering criteria, quality control, and imputation at each site may be found in
<xref ref-type="supplementary-material" rid="S1">Supplementary Data 3</xref>
.</p>
</sec>
<sec disp-level="2">
<title>Genome-wide association analysis and statistical models</title>
<p>GWAS were performed at each site, as follows. Mean bilateral hippocampal volume ((left+right)/2) was the trait of interest, and the additive dosage value of a SNP was the predictor of interest, while controlling for 4 MDS components, age, age
<sup>2</sup>
, sex, intracranial volume and diagnosis (when applicable). For studies with data collected from multiple centres or scanners, additional covariates were also included in the model to adjust for any scanning site effects. Sites with family data (NTR-Adults, BrainSCALE, QTIM, SYS, GOBS, ASPSFam, ERF, GeneSTAR, NeuroIMAGE, OATS, RSIx) used mixed-effects models to account for familial relationships, in addition to covariates stated previously. The primary analyses for this paper focused on the full set of individuals, including datasets with patients, to maximize power. We re-analysed the data excluding patients to verify that detected effects were not due to disease alone. The regression coefficients for SNPs with
<italic>P</italic>
<1 × 10
<sup>−5</sup>
in the model including all patients were almost perfectly correlated with the regression coefficients from the model including only healthy individuals (Pearson's
<italic>r</italic>
=0.996). Full details for the software used at each site are given in
<xref ref-type="supplementary-material" rid="S1">Supplementary Data 3</xref>
.</p>
<p>The GWAS of mean hippocampal volume was performed at each site, and the resulting summary statistics uploaded to a centralized site for meta-analysis. Before meta-analysis, GWAS results from each site were checked for genomic inflation and errors using Quantile–Quantile (QQ) plots (
<xref ref-type="supplementary-material" rid="S1">Supplementary Figs 1 and 2</xref>
). GWAS results from each site were combined using a fixed-effects sample size-weighted meta-analysis framework as implemented in METAL
<xref ref-type="bibr" rid="b49">49</xref>
. Data were meta-analysed first in the ENIGMA and CHARGE Consortia separately and then combined into a final meta-analysed result file. After the final meta-analysis, SNPs were excluded if the SNP was available for fewer than 5,000 individuals.</p>
</sec>
<sec disp-level="2">
<title>Variance explained and genetic overlap in hippocampal volume</title>
<p>The common genetic overlap, total variance explained by the GWAS, and the partitioned heritability analyses were estimated using LDSCORE
<xref ref-type="bibr" rid="b25">25</xref>
<xref ref-type="bibr" rid="b26">26</xref>
. Following from the polygenic model, an association test statistic at a given locus includes signal from all linked loci. Given a heritable polygenic trait, a SNP in high LD with, or tagging, a large number of SNPs is on average likely to show stronger association than a SNP that is not. The magnitude of information conveyed by each variant (a function of the number of SNPs tagged taking into account the strength of the tagging) is summarized as an LD score. By regressing the LD scores on the test statistics, we estimated the proportion of variance in the trait explained by the variants included in the analysis. As an extension, two LD score models for two separate traits can be used to estimate the covariance (and correlation) structure to yield an estimate of the common genetic overlap (
<italic>r</italic>
<sub>g</sub>
) between any two trait pairs. Here we estimated the common genetic overlap between hippocampal volume and Alzheimer's disease
<xref ref-type="bibr" rid="b50">50</xref>
. Standard errors were estimated using a block jackknife.</p>
</sec>
<sec disp-level="2">
<title>Genomic partitioning into functional categories</title>
<p>As well as estimating the total variance explained, the genomic heritability (
<italic>h</italic>
<sup>2</sup>
<sub>g</sub>
) can be partitioned into specific subsets of variants. The functional annotation partitioning used the pre-prepared LDSCORE and annotation (.annot) files available online (see URLs) following the method of Finucane
<italic>et al</italic>
.
<xref ref-type="bibr" rid="b26">26</xref>
. These analyses use the following 24 functional classes not specifically unique to any cell type: coding, UTR, promoter, intron, histone marks H3K4me1, H3K4me3, H3K9ac5 and two versions of H3K27ac, open chromatin DNase I hypersensitivity Site (DHS) regions, combined chromHMM/Segway predictions, regions conserved in mammals, super-enhancers and active enhancers from the FANTOM5 panel of samples (Finucane
<italic>et al</italic>
., page 4)
<xref ref-type="bibr" rid="b26">26</xref>
. Annotated coordinates are determined by a combination of all cell types from ENCODE. As in Finucane
<italic>et al</italic>
.
<xref ref-type="bibr" rid="b26">26</xref>
, to avoid bias, we included the 500 bp windows surrounding the variants included in the functional classes. The chromosome-partitioned analyses were conducted using LDSCOREs calculated for each chromosome. Following the method of Bulik-Sullivan
<italic>et al</italic>
.
<xref ref-type="bibr" rid="b25">25</xref>
, these analyses focus on the variants within HapMap3 as these SNPs are typically well imputed across cohorts. Enrichment of a given partition is calculated as the proportion of
<italic>h</italic>
<sup>2</sup>
<sub>g</sub>
explained by that partition divided by the proportion of variants in the GWAS that fall into that partition. All LDSCORE analyses used non-genomic controlled meta-analyses.</p>
</sec>
<sec disp-level="2">
<title>Gene annotation and pathway analysis</title>
<p>Gene annotation, gene-based test statistics, and pathway analysis were performed using the KGG2.5 software package
<xref ref-type="bibr" rid="b51">51</xref>
(
<xref ref-type="supplementary-material" rid="S1">Supplementary Data 6 and 7</xref>
). LD was calculated based on RSID numbers using the 1000 Genomes Project European samples as a reference (see URLs). For annotation, SNPs were considered ‘within' a gene, if they fell within 5 kb of the 3′/5′ UTR based on human genome (hg19) coordinates. Gene-based tests were performed using the GATES test
<xref ref-type="bibr" rid="b51">51</xref>
without weighting
<italic>P</italic>
values by predicted functional relevance. Pathway analysis was performed using the HYST test of association
<xref ref-type="bibr" rid="b52">52</xref>
. For all gene-based tests and pathway analyses, results were considered significant if they exceeded a Bonferroni correction threshold accounting for the number of pathways in the REACTOME database tested such that
<italic>P</italic>
<sub>thresh</sub>
=0.05/(671 pathways)=7.45 × 10
<sup>−5</sup>
.</p>
</sec>
<sec disp-level="2">
<title>Annotation of SNPs with epigenetic factors</title>
<p>In
<xref ref-type="fig" rid="f2">Fig. 2</xref>
, all tracks were taken from the UCSC Genome Browser Human hg19 assembly.
<italic>SNPs (top 5%)</italic>
shows the top 5% associated SNPs within the locus and are coloured by their correlation to the top SNP.
<italic>Genes</italic>
shows the gene models from GENCODE version 19.
<italic>Hippocampus</italic>
gives the predicted chromatin states based on computational integration of ChIP-seq data for 18 chromatin marks in human hippocampal tissue derived from the Roadmap Epigenomics Consortium
<xref ref-type="bibr" rid="b53">53</xref>
. The 18 chromatin states from the
<italic>hippocampus</italic>
track are as follows: TssA (Active TSS), TssFlnk (Flanking Active TSS), TssFlnkU (Flanking TSS Upstream), TssFlnkD (Flanking TSS Downstream), Tx (Strong transcription), TxWk (Weak transcription), EnhG1 (Genic Enhancers 1), EnhG2 (Genic Enhancers 2), EnhA1 (Active Enhancers 1), EnhA2 (Active Enhancers 2), EnhWk (Weak Enhancers), ZNF/Rpts (ZNF genes & repeats), Het (Heterochromatin), TssBiv (Bivalent/Poised TSS), EnhBiv (Bivalent Enhancer), ReprPC (Repressed PolyComb), ReprPCWk (Weak Repressed PolyComb), Quies (Quiescent/Low). Additional information about the 18 state chromatin model is detailed elsewhere
<xref ref-type="bibr" rid="b53">53</xref>
.
<italic>Conservation</italic>
is the basewise conservation score over 100 vertebrates estimated by PhyloP from the UCSC Genome Browser Human hg19 assembly.</p>
</sec>
<sec disp-level="2">
<title>Analysis of hippocampal subfields</title>
<p>We segmented the hippocampal formation into 13 subfield regions: CA1, CA3, CA4, fimbria, Granule Layer+Molecular Layer+Dentate Gyrus Boundary (GC_ML_DG), hippocampal-amygdaloid transition area (HATA), hippocampal tail, hippocampal fissure, molecular layer (HP), parasubiculum, presubiculum and subiculum using a freely available, validated algorithm distributed with the FreeSurfer image analysis package
<xref ref-type="bibr" rid="b54">54</xref>
. We measured the hippocampal subfield volumes within the Rotterdam (
<italic>n</italic>
=4,491) and HUNT (
<italic>n</italic>
=877) cohorts. Volumes from the 26 subfield regions (13 in each hemisphere) were the phenotypes of interest and individually assessed for significance with the top variants from our primary analysis while correcting for the following nuisance variables: 4 MDS components, age, age
<sup>2</sup>
, sex, intracranial volume. Association statistics from each of the tests in the Rotterdam and HUNT cohorts were meta-analysed using a fixed-effects inverse variance-weighted model yielding the final results. We declare an individual test significant if the
<italic>P</italic>
value is less than a Bonferroni-corrected
<italic>P</italic>
value threshold accounting for the total number of tests:
<italic>P</italic>
<sub>thresh</sub>
=0.05/(26 subfields × 6 SNPs)=3.21 × 10
<sup>−4</sup>
.</p>
</sec>
<sec disp-level="2">
<title>Data availability</title>
<p>The genome-wide summary statistics that support the findings of this study are available upon request from the corresponding authors MAI and PMT (see URLs). The data are not publicly available due to them containing information that could compromise research participant privacy/consent.</p>
</sec>
<sec disp-level="2">
<title>URLs</title>
<p>
<ext-link ext-link-type="uri" xlink:href="https://github.com/bulik/ldsc">https://github.com/bulik/ldsc</ext-link>
</p>
<p>
<ext-link ext-link-type="uri" xlink:href="http://enigma.usc.edu/protocols/genetics-protocols/">http://enigma.usc.edu/protocols/genetics-protocols/</ext-link>
</p>
<p>
<ext-link ext-link-type="uri" xlink:href="http://gump.qimr.edu.au/general/gabrieC/LocusTrack/">http://gump.qimr.edu.au/general/gabrieC/LocusTrack/</ext-link>
</p>
<p>
<ext-link ext-link-type="uri" xlink:href="http://enigma.ini.usc.edu/download-enigma-gwas-results/">http://enigma.ini.usc.edu/download-enigma-gwas-results/</ext-link>
</p>
<p>
<ext-link ext-link-type="uri" xlink:href="http://www.internationalgenome.org/data">http://www.internationalgenome.org/data</ext-link>
</p>
</sec>
</sec>
<sec disp-level="1">
<title>Additional information</title>
<p>
<bold>How to cite this article:</bold>
Hibar, D. P.
<italic>et al</italic>
. Novel genetic loci associated with hippocampal volume.
<italic>Nat. Commun.</italic>
<bold>8</bold>
, 13624 doi: 10.1038/ncomms13624 (2017).</p>
<p>
<bold>Publisher's note:</bold>
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</sec>
<sec sec-type="supplementary-material" id="S1">
<title>Supplementary Material</title>
<supplementary-material id="d32e18" content-type="local-data">
<caption>
<title>Supplementary Information</title>
<p>Supplementary Figures 1-3, Supplementary Notes 1-3</p>
</caption>
<media xlink:href="ncomms13624-s1.pdf"></media>
</supplementary-material>
<supplementary-material id="d32e24" content-type="local-data">
<caption>
<title>Supplementary Data 1</title>
<p>Demographic description of cohorts included in the analysis</p>
</caption>
<media xlink:href="ncomms13624-s2.xlsx"></media>
</supplementary-material>
</sec>
</body>
<back>
<ack>
<p>See
<xref ref-type="supplementary-material" rid="S1">Supplementary Note 2</xref>
for information on funding sources. Data used in preparing this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). such, many investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report (see
<xref ref-type="supplementary-material" rid="S1">Supplementary Note 1</xref>
). A complete listing of ADNI investigators can be found at:
<ext-link ext-link-type="uri" xlink:href="http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf">http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf</ext-link>
</p>
</ack>
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See
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for author contribution statements.</p>
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<floats-group>
<fig id="f1">
<label>Figure 1</label>
<caption>
<title>
<bold>Common genetic variants associated with hippocampal volume (</bold>
<italic>
<bold>N</bold>
</italic>
<bold>=26,814 of European ancestry).</bold>
</title>
<p>A Manhattan plot displays the association
<italic>P</italic>
value for each single-nucleotide polymorphism (SNP) in the genome (displayed as –log
<sub>10</sub>
of the
<italic>P</italic>
-value). Genome-wide significance is shown for the
<italic>P</italic>
=5 × 10
<sup>−8</sup>
threshold (solid line) and also for the suggestive significance threshold of
<italic>P</italic>
=1 × 10
<sup>−6</sup>
(dotted line). The most significant SNP within an associated locus is labeled. For the significant loci and age-dependent loci (Chromosome 19) we labeled the nearest gene, which is not necessarily the gene of action.</p>
</caption>
<graphic xlink:href="ncomms13624-f1"></graphic>
</fig>
<fig id="f2">
<label>Figure 2</label>
<caption>
<title>Functional annotation within genome-wide significant loci.</title>
<p>For each panel (
<bold>a</bold>
–
<bold>f</bold>
), zoomed-in Manhattan plots (±400 kb from top SNP) are shown with gene models below (GENCODE version 19). Plots below are zoomed to highlight the genomic region that likely harbors the causal variant(s) (
<italic>r</italic>
<sup>2</sup>
>0.8 from the top SNP). Genomic annotations from the Roadmap Epigenomics Consortium
<xref ref-type="bibr" rid="b53">53</xref>
are displayed to indicate potential functionality (see Methods for detailed track information). Each plot was made using the LocusTrack software
<xref ref-type="bibr" rid="b55">55</xref>
(see URLs).</p>
</caption>
<graphic xlink:href="ncomms13624-f2"></graphic>
</fig>
<fig id="f3">
<label>Figure 3</label>
<caption>
<title>Analysis of variance explained, functional annotation, and pathway analysis.</title>
<p>LDSCORE regression analysis for different functional annotation
<xref ref-type="bibr" rid="b26">26</xref>
categories (described further in Finucane
<italic>et al</italic>
.
<xref ref-type="bibr" rid="b26">26</xref>
). Plotted values are the proportion of
<italic>h</italic>
<sup>2</sup>
<sub>g</sub>
explained divided by the proportion of SNPs in a given functional category. Values are significantly over- or under-represented if they differ significantly from 1. Values are plotted with a standard error calculated with a jackknife in LDSCORE. Evolutionarily conserved regions across mammals significantly contributed to the heritability of hippocampal volume (indicated by **).</p>
</caption>
<graphic xlink:href="ncomms13624-f3"></graphic>
</fig>
<table-wrap position="float" id="t1">
<label>Table 1</label>
<caption>
<title>Genetic variants at six loci were significantly associated with hippocampal volume.</title>
</caption>
<table frame="hsides" rules="groups" border="1">
<colgroup>
<col align="left"></col>
<col align="center"></col>
<col align="center"></col>
<col align="left"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
</colgroup>
<thead valign="bottom">
<tr>
<th align="left" valign="top" charoff="50">
<bold>RSID</bold>
</th>
<th align="center" valign="top" charoff="50">
<bold>Chr</bold>
</th>
<th align="center" valign="top" charoff="50">
<bold>Pos</bold>
</th>
<th align="left" valign="top" charoff="50">
<bold>Nearest gene</bold>
</th>
<th align="center" valign="top" charoff="50">
<bold>Allele1</bold>
</th>
<th align="center" valign="top" charoff="50">
<bold>Allele2</bold>
</th>
<th align="center" valign="top" charoff="50">
<bold>Freq</bold>
</th>
<th align="center" valign="top" charoff="50">
<italic>
<bold>Z</bold>
</italic>
<bold>-score</bold>
</th>
<th align="center" valign="top" charoff="50">
<italic>
<bold>N</bold>
</italic>
</th>
<th align="center" valign="top" charoff="50">
<italic>
<bold>P</bold>
</italic>
<bold>value</bold>
</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left" valign="top" charoff="50">
<bold>rs77956314</bold>
</td>
<td align="center" valign="top" charoff="50">12</td>
<td align="center" valign="top" charoff="50">117,323,367</td>
<td align="left" valign="top" charoff="50">4 kb 5′ to
<italic>HRK</italic>
</td>
<td align="center" valign="top" charoff="50">T</td>
<td align="center" valign="top" charoff="50">C</td>
<td align="center" valign="top" charoff="50">0.9160</td>
<td align="center" valign="top" charoff="50">−10.418</td>
<td align="center" valign="top" charoff="50">26,814</td>
<td align="center" valign="top" charoff="50">2.06 × 10
<sup>−25</sup>
</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50">
<bold>rs61921502</bold>
</td>
<td align="center" valign="top" charoff="50">12</td>
<td align="center" valign="top" charoff="50">65,832,468</td>
<td align="left" valign="top" charoff="50">Intron of
<italic>MSRB3</italic>
</td>
<td align="center" valign="top" charoff="50">T</td>
<td align="center" valign="top" charoff="50">G</td>
<td align="center" valign="top" charoff="50">0.8466</td>
<td align="center" valign="top" charoff="50">9.017</td>
<td align="center" valign="top" charoff="50">26,814</td>
<td align="center" valign="top" charoff="50">1.94 × 10
<sup>−19</sup>
</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50">
<bold>rs11979341</bold>
</td>
<td align="center" valign="top" charoff="50">7</td>
<td align="center" valign="top" charoff="50">155,797,978</td>
<td align="left" valign="top" charoff="50">200 kb 5′ to
<italic>SHH</italic>
</td>
<td align="center" valign="top" charoff="50">C</td>
<td align="center" valign="top" charoff="50">G</td>
<td align="center" valign="top" charoff="50">0.6837</td>
<td align="center" valign="top" charoff="50">−6.755</td>
<td align="center" valign="top" charoff="50">24,484</td>
<td align="center" valign="top" charoff="50">1.42 × 10
<sup>−11</sup>
</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50">
<bold>rs7020341</bold>
</td>
<td align="center" valign="top" charoff="50">9</td>
<td align="center" valign="top" charoff="50">119,247,974</td>
<td align="left" valign="top" charoff="50">Intron of
<italic>ASTN2</italic>
</td>
<td align="center" valign="top" charoff="50">C</td>
<td align="center" valign="top" charoff="50">G</td>
<td align="center" valign="top" charoff="50">0.3590</td>
<td align="center" valign="top" charoff="50">6.645</td>
<td align="center" valign="top" charoff="50">26,700</td>
<td align="center" valign="top" charoff="50">3.04 × 10
<sup>−11</sup>
</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50">
<bold>rs2268894</bold>
</td>
<td align="center" valign="top" charoff="50">2</td>
<td align="center" valign="top" charoff="50">162,856,148</td>
<td align="left" valign="top" charoff="50">Intron of
<italic>DPP4</italic>
</td>
<td align="center" valign="top" charoff="50">T</td>
<td align="center" valign="top" charoff="50">C</td>
<td align="center" valign="top" charoff="50">0.5412</td>
<td align="center" valign="top" charoff="50">−6.546</td>
<td align="center" valign="top" charoff="50">26,814</td>
<td align="center" valign="top" charoff="50">5.89 × 10
<sup>−11</sup>
</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50">
<bold>rs2289881</bold>
</td>
<td align="center" valign="top" charoff="50">5</td>
<td align="center" valign="top" charoff="50">66,084,260</td>
<td align="left" valign="top" charoff="50">Intron of
<italic>MAST4</italic>
</td>
<td align="center" valign="top" charoff="50">T</td>
<td align="center" valign="top" charoff="50">G</td>
<td align="center" valign="top" charoff="50">0.3544</td>
<td align="center" valign="top" charoff="50">−5.558</td>
<td align="center" valign="top" charoff="50">26,814</td>
<td align="center" valign="top" charoff="50">2.73 × 10
<sup>−8</sup>
</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="t1-fn1">
<p>The allele frequency (Freq) and effect size (
<italic>Z</italic>
-score) are given with reference to Allele 1. Effect sizes are additive effects for each copy of Allele 1 given as a
<italic>Z</italic>
-score. Additional validation was attempted in non-European ancestry generalization samples (shown in
<xref ref-type="supplementary-material" rid="S1">Supplementary Data 5</xref>
).</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
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