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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">FANTOM5 CAGE profiles of human and mouse samples</title><author><name sortKey="Noguchi, Shuhei" sort="Noguchi, Shuhei" uniqKey="Noguchi S" first="Shuhei" last="Noguchi">Shuhei Noguchi</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Arakawa, Takahiro" sort="Arakawa, Takahiro" uniqKey="Arakawa T" first="Takahiro" last="Arakawa">Takahiro Arakawa</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Fukuda, Shiro" sort="Fukuda, Shiro" uniqKey="Fukuda S" first="Shiro" last="Fukuda">Shiro Fukuda</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Furuno, Masaaki" sort="Furuno, Masaaki" uniqKey="Furuno M" first="Masaaki" last="Furuno">Masaaki Furuno</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Hasegawa, Akira" sort="Hasegawa, Akira" uniqKey="Hasegawa A" first="Akira" last="Hasegawa">Akira Hasegawa</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Hori, Fumi" sort="Hori, Fumi" uniqKey="Hori F" first="Fumi" last="Hori">Fumi Hori</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ishikawa Kato, Sachi" sort="Ishikawa Kato, Sachi" uniqKey="Ishikawa Kato S" first="Sachi" last="Ishikawa-Kato">Sachi Ishikawa-Kato</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kaida, Kaoru" sort="Kaida, Kaoru" uniqKey="Kaida K" first="Kaoru" last="Kaida">Kaoru Kaida</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kaiho, Ai" sort="Kaiho, Ai" uniqKey="Kaiho A" first="Ai" last="Kaiho">Ai Kaiho</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kanamori Katayama, Mutsumi" sort="Kanamori Katayama, Mutsumi" uniqKey="Kanamori Katayama M" first="Mutsumi" last="Kanamori-Katayama">Mutsumi Kanamori-Katayama</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kawashima, Tsugumi" sort="Kawashima, Tsugumi" uniqKey="Kawashima T" first="Tsugumi" last="Kawashima">Tsugumi Kawashima</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kojima, Miki" sort="Kojima, Miki" uniqKey="Kojima M" first="Miki" last="Kojima">Miki Kojima</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kubosaki, Atsutaka" sort="Kubosaki, Atsutaka" uniqKey="Kubosaki A" first="Atsutaka" last="Kubosaki">Atsutaka Kubosaki</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Manabe, Ri Ichiroh" sort="Manabe, Ri Ichiroh" uniqKey="Manabe R" first="Ri-Ichiroh" last="Manabe">Ri-Ichiroh Manabe</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Murata, Mitsuyoshi" sort="Murata, Mitsuyoshi" uniqKey="Murata M" first="Mitsuyoshi" last="Murata">Mitsuyoshi Murata</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nagao Sato, Sayaka" sort="Nagao Sato, Sayaka" uniqKey="Nagao Sato S" first="Sayaka" last="Nagao-Sato">Sayaka Nagao-Sato</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nakazato, Kenichi" sort="Nakazato, Kenichi" uniqKey="Nakazato K" first="Kenichi" last="Nakazato">Kenichi Nakazato</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ninomiya, Noriko" sort="Ninomiya, Noriko" uniqKey="Ninomiya N" first="Noriko" last="Ninomiya">Noriko Ninomiya</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nishiyori Sueki, Hiromi" sort="Nishiyori Sueki, Hiromi" uniqKey="Nishiyori Sueki H" first="Hiromi" last="Nishiyori-Sueki">Hiromi Nishiyori-Sueki</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Noma, Shohei" sort="Noma, Shohei" uniqKey="Noma S" first="Shohei" last="Noma">Shohei Noma</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Saijyo, Eri" sort="Saijyo, Eri" uniqKey="Saijyo E" first="Eri" last="Saijyo">Eri Saijyo</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Saka, Akiko" sort="Saka, Akiko" uniqKey="Saka A" first="Akiko" last="Saka">Akiko Saka</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sakai, Mizuho" sort="Sakai, Mizuho" uniqKey="Sakai M" first="Mizuho" last="Sakai">Mizuho Sakai</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Simon, Christophe" sort="Simon, Christophe" uniqKey="Simon C" first="Christophe" last="Simon">Christophe Simon</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Suzuki, Naoko" sort="Suzuki, Naoko" uniqKey="Suzuki N" first="Naoko" last="Suzuki">Naoko Suzuki</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Tagami, Michihira" sort="Tagami, Michihira" uniqKey="Tagami M" first="Michihira" last="Tagami">Michihira Tagami</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Watanabe, Shoko" sort="Watanabe, Shoko" uniqKey="Watanabe S" first="Shoko" last="Watanabe">Shoko Watanabe</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Yoshida, Shigehiro" sort="Yoshida, Shigehiro" uniqKey="Yoshida S" first="Shigehiro" last="Yoshida">Shigehiro Yoshida</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Arner, Peter" sort="Arner, Peter" uniqKey="Arner P" first="Peter" last="Arner">Peter Arner</name><affiliation><nlm:aff id="a3"><institution>Department of Medicine, Karolinska Institutet</institution>, 141 86, Stockholm,<country>Sweden</country></nlm:aff></affiliation><affiliation><nlm:aff id="a4"><institution>Karolinska University Hospital, Center for Metabolism and Endocrinology</institution>, 141 86, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Axton, Richard A" sort="Axton, Richard A" uniqKey="Axton R" first="Richard A." last="Axton">Richard A. Axton</name><affiliation><nlm:aff id="a5"><institution>Scottish Centre for Regenerative Medicine, University of Edinburgh</institution>, 5 Little France Drive, Edinburgh EH16 4UU,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Babina, Magda" sort="Babina, Magda" uniqKey="Babina M" first="Magda" last="Babina">Magda Babina</name><affiliation><nlm:aff id="a6"><institution>Department of Dermatology and Allergy, Charite University Medicine Berlin</institution>, Charitéplatz 1, 10117 Berlin,<country>German</country></nlm:aff></affiliation></author><author><name sortKey="Baillie, J Kenneth" sort="Baillie, J Kenneth" uniqKey="Baillie J" first="J. Kenneth" last="Baillie">J. Kenneth Baillie</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Barnett, Timothy C" sort="Barnett, Timothy C" uniqKey="Barnett T" first="Timothy C." last="Barnett">Timothy C. Barnett</name><affiliation><nlm:aff id="a8"><institution>Australian Infectious Diseases Research Centre, The University of Queensland</institution>, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="a9"><institution>School of Chemistry and Molecular Biosciences, The University of Queensland</institution>, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Beckhouse, Anthony G" sort="Beckhouse, Anthony G" uniqKey="Beckhouse A" first="Anthony G." last="Beckhouse">Anthony G. Beckhouse</name><affiliation><nlm:aff id="a10"><institution>Bio-Rad Laboratories Pty Ltd</institution>, Hercules, California 94547,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Blumenthal, Antje" sort="Blumenthal, Antje" uniqKey="Blumenthal A" first="Antje" last="Blumenthal">Antje Blumenthal</name><affiliation><nlm:aff id="a11"><institution>The University of Queensland Diamantina Institute, The University of Queensland</institution>, Woolloongabba, QLD 4102<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Bodega, Beatrice" sort="Bodega, Beatrice" uniqKey="Bodega B" first="Beatrice" last="Bodega">Beatrice Bodega</name><affiliation><nlm:aff id="a12"><institution>IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64</institution>, 00143 Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Bonetti, Alessandro" sort="Bonetti, Alessandro" uniqKey="Bonetti A" first="Alessandro" last="Bonetti">Alessandro Bonetti</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Briggs, James" sort="Briggs, James" uniqKey="Briggs J" first="James" last="Briggs">James Briggs</name><affiliation><nlm:aff id="a13"><institution>Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland</institution>, Brisbane, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Brombacher, Frank" sort="Brombacher, Frank" uniqKey="Brombacher F" first="Frank" last="Brombacher">Frank Brombacher</name><affiliation><nlm:aff id="a14"><institution>Division of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a15"><institution>Immunology of Infectious Diseases, Faculty of Health Sciences, South African Medical Research Council (SAMRC), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a16"><institution>International Centre for Genetic Engineering and Biotechnology, Cape Town Component</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation></author><author><name sortKey="Carlisle, Ailsa J" sort="Carlisle, Ailsa J" uniqKey="Carlisle A" first="Ailsa J." last="Carlisle">Ailsa J. Carlisle</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Clevers, Hans C" sort="Clevers, Hans C" uniqKey="Clevers H" first="Hans C." last="Clevers">Hans C. Clevers</name><affiliation><nlm:aff id="a17"><institution>Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences</institution>, Uppsalalaan 8, 3584 CT Utrecht,<country>The Netherlands</country></nlm:aff></affiliation><affiliation><nlm:aff id="a18"><institution>University Medical Centre Utrecht</institution>, Postbus 85500, 3508 GA Utrecht,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Davis, Carrie A" sort="Davis, Carrie A" uniqKey="Davis C" first="Carrie A." last="Davis">Carrie A. Davis</name><affiliation><nlm:aff id="a19"><institution>Genomics, Cold Spring Harbor Laboratory</institution>, Cold Spring Harbor, New York 11797,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name><affiliation><nlm:aff id="a20"><institution>Institute of Pharmaceutical Sciences, ETH Zurich</institution>, Vladimir-Prelog-Weg 3, HCI H 303, 8093 Zurich,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Dohi, Taeko" sort="Dohi, Taeko" uniqKey="Dohi T" first="Taeko" last="Dohi">Taeko Dohi</name><affiliation><nlm:aff id="a21"><institution>Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute National Center for Global Health and Medicine</institution>, Ichikawa, Chiba 272-8516,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Edge, Albert S B" sort="Edge, Albert S B" uniqKey="Edge A" first="Albert S. B." last="Edge">Albert S. B. Edge</name><affiliation><nlm:aff id="a22"><institution>Department of Otology and Laryngology, Harvard Medical School</institution>, Boston, Massachusetts 02114,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Edinger, Matthias" sort="Edinger, Matthias" uniqKey="Edinger M" first="Matthias" last="Edinger">Matthias Edinger</name><affiliation><nlm:aff id="a23"><institution>Department of Internal Medicine III, University Hospital Regensburg</institution>, F.-J.-Strauss Allee 11, D-93053 Regensburg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="a24"><institution>RCI Regensburg Centre for Interventional Immunology, University Hospital Regensburg</institution>, F.-J.-Strauss Allee 11, D-93053 Regensburg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ehrlund, Anna" sort="Ehrlund, Anna" uniqKey="Ehrlund A" first="Anna" last="Ehrlund">Anna Ehrlund</name><affiliation><nlm:aff id="a3"><institution>Department of Medicine, Karolinska Institutet</institution>, 141 86, Stockholm,<country>Sweden</country></nlm:aff></affiliation><affiliation><nlm:aff id="a4"><institution>Karolinska University Hospital, Center for Metabolism and Endocrinology</institution>, 141 86, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Ekwall, Karl" sort="Ekwall, Karl" uniqKey="Ekwall K" first="Karl" last="Ekwall">Karl Ekwall</name><affiliation><nlm:aff id="a25"><institution>Department of Biosciences and Nutrition, Karolinska Institutet</institution>, Halsovagen 7-9, SE-141 83 Huddinge,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Endoh, Mitsuhiro" sort="Endoh, Mitsuhiro" uniqKey="Endoh M" first="Mitsuhiro" last="Endoh">Mitsuhiro Endoh</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Enomoto, Hideki" sort="Enomoto, Hideki" uniqKey="Enomoto H" first="Hideki" last="Enomoto">Hideki Enomoto</name><affiliation><nlm:aff id="a27"><institution>Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology</institution>, Chuou-ku, Kobe 650-0047,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Eslami, Afsaneh" sort="Eslami, Afsaneh" uniqKey="Eslami A" first="Afsaneh" last="Eslami">Afsaneh Eslami</name><affiliation><nlm:aff id="a28"><institution>Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University</institution>, Bunkyo-ku, Tokyo 113-8510,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Fagiolini, Michela" sort="Fagiolini, Michela" uniqKey="Fagiolini M" first="Michela" last="Fagiolini">Michela Fagiolini</name><affiliation><nlm:aff id="a29"><institution>F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Fairbairn, Lynsey" sort="Fairbairn, Lynsey" uniqKey="Fairbairn L" first="Lynsey" last="Fairbairn">Lynsey Fairbairn</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Farach Carson, Mary C" sort="Farach Carson, Mary C" uniqKey="Farach Carson M" first="Mary C." last="Farach-Carson">Mary C. Farach-Carson</name><affiliation><nlm:aff id="a30"><institution>The University of Texas Health Science Center at Houston</institution>, Houston, TX 77251-1892,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Faulkner, Geoffrey J" sort="Faulkner, Geoffrey J" uniqKey="Faulkner G" first="Geoffrey J." last="Faulkner">Geoffrey J. Faulkner</name><affiliation><nlm:aff id="a31"><institution>Cancer Biology Program, Mater Medical Research Institute</institution>, South Brisbane, Queensland 4101,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Ferrai, Carmelo" sort="Ferrai, Carmelo" uniqKey="Ferrai C" first="Carmelo" last="Ferrai">Carmelo Ferrai</name><affiliation><nlm:aff id="a32"><institution>Berlin Institute for Medical Systems Biology, Max Delbrueck Center</institution>, Robert Roessle Str.10, 13125 Berlin,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Fisher, Malcolm E" sort="Fisher, Malcolm E" uniqKey="Fisher M" first="Malcolm E." last="Fisher">Malcolm E. Fisher</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Forrester, Lesley M" sort="Forrester, Lesley M" uniqKey="Forrester L" first="Lesley M." last="Forrester">Lesley M. Forrester</name><affiliation><nlm:aff id="a5"><institution>Scottish Centre for Regenerative Medicine, University of Edinburgh</institution>, 5 Little France Drive, Edinburgh EH16 4UU,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Fujita, Rie" sort="Fujita, Rie" uniqKey="Fujita R" first="Rie" last="Fujita">Rie Fujita</name><affiliation><nlm:aff id="a33"><institution>Department of Medical Biochemistry, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Furusawa, Jun Ichi" sort="Furusawa, Jun Ichi" uniqKey="Furusawa J" first="Jun-Ichi" last="Furusawa">Jun-Ichi Furusawa</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Geijtenbeek, Teunis B" sort="Geijtenbeek, Teunis B" uniqKey="Geijtenbeek T" first="Teunis B." last="Geijtenbeek">Teunis B. Geijtenbeek</name><affiliation><nlm:aff id="a34"><institution>Experimental Immunology, Academic Medical Center, University of Amsterdam</institution>, Meibergdreef 9, 1105 AZ Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Gingeras, Thomas" sort="Gingeras, Thomas" uniqKey="Gingeras T" first="Thomas" last="Gingeras">Thomas Gingeras</name><affiliation><nlm:aff id="a19"><institution>Genomics, Cold Spring Harbor Laboratory</institution>, Cold Spring Harbor, New York 11797,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Goldowitz, Daniel" sort="Goldowitz, Daniel" uniqKey="Goldowitz D" first="Daniel" last="Goldowitz">Daniel Goldowitz</name><affiliation><nlm:aff id="a35"><institution>Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia</institution>, Vancouver, British Columbia V5Z 4H4,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Guhl, Sven" sort="Guhl, Sven" uniqKey="Guhl S" first="Sven" last="Guhl">Sven Guhl</name><affiliation><nlm:aff id="a6"><institution>Department of Dermatology and Allergy, Charite University Medicine Berlin</institution>, Charitéplatz 1, 10117 Berlin,<country>German</country></nlm:aff></affiliation></author><author><name sortKey="Guler, Reto" sort="Guler, Reto" uniqKey="Guler R" first="Reto" last="Guler">Reto Guler</name><affiliation><nlm:aff id="a14"><institution>Division of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a15"><institution>Immunology of Infectious Diseases, Faculty of Health Sciences, South African Medical Research Council (SAMRC), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a16"><institution>International Centre for Genetic Engineering and Biotechnology, Cape Town Component</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation></author><author><name sortKey="Gustincich, Stefano" sort="Gustincich, Stefano" uniqKey="Gustincich S" first="Stefano" last="Gustincich">Stefano Gustincich</name><affiliation><nlm:aff id="a36"><institution>Neuroscience, SISSA</institution>, Via Bonomea 265, 34136 Trieste,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="a37"><institution>Department of Neuroscience and Brian Technologies, Italian Istitute of Technology</institution>, Via Morego 30, Genova,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Ha, Thomas J" sort="Ha, Thomas J" uniqKey="Ha T" first="Thomas J." last="Ha">Thomas J. Ha</name><affiliation><nlm:aff id="a35"><institution>Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia</institution>, Vancouver, British Columbia V5Z 4H4,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Hamaguchi, Masahide" sort="Hamaguchi, Masahide" uniqKey="Hamaguchi M" first="Masahide" last="Hamaguchi">Masahide Hamaguchi</name><affiliation><nlm:aff id="a38"><institution>Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University</institution>, Suita, Osaka 565-0871,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Hara, Mitsuko" sort="Hara, Mitsuko" uniqKey="Hara M" first="Mitsuko" last="Hara">Mitsuko Hara</name><affiliation><nlm:aff id="a39"><institution>RIKEN Center for Life Science Technologies</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Hasegawa, Yuki" sort="Hasegawa, Yuki" uniqKey="Hasegawa Y" first="Yuki" last="Hasegawa">Yuki Hasegawa</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Herlyn, Meenhard" sort="Herlyn, Meenhard" uniqKey="Herlyn M" first="Meenhard" last="Herlyn">Meenhard Herlyn</name><affiliation><nlm:aff id="a40"><institution>Melanoma Research Center, The Wistar Institute</institution>, Philadelphia, Pennsylvania 19104,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name><affiliation><nlm:aff id="a41"><institution>German Center for Neurodegenerative Diseases (DZNE)-Tübingen</institution>, Otfried Müller Straße 23, 72076 Tübingen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Hitchens, Kelly J" sort="Hitchens, Kelly J" uniqKey="Hitchens K" first="Kelly J." last="Hitchens">Kelly J. Hitchens</name><affiliation><nlm:aff id="a8"><institution>Australian Infectious Diseases Research Centre, The University of Queensland</institution>, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="a13"><institution>Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland</institution>, Brisbane, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Hume, David A" sort="Hume, David A" uniqKey="Hume D" first="David A." last="Hume">David A. Hume</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Ikawa, Tomokatsu" sort="Ikawa, Tomokatsu" uniqKey="Ikawa T" first="Tomokatsu" last="Ikawa">Tomokatsu Ikawa</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ishizu, Yuri" sort="Ishizu, Yuri" uniqKey="Ishizu Y" first="Yuri" last="Ishizu">Yuri Ishizu</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kai, Chieko" sort="Kai, Chieko" uniqKey="Kai C" first="Chieko" last="Kai">Chieko Kai</name><affiliation><nlm:aff id="a42"><institution>Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a43"><institution>International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kawamoto, Hiroshi" sort="Kawamoto, Hiroshi" uniqKey="Kawamoto H" first="Hiroshi" last="Kawamoto">Hiroshi Kawamoto</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kawamura, Yuki I" sort="Kawamura, Yuki I" uniqKey="Kawamura Y" first="Yuki I." last="Kawamura">Yuki I. Kawamura</name><affiliation><nlm:aff id="a21"><institution>Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute National Center for Global Health and Medicine</institution>, Ichikawa, Chiba 272-8516,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kempfle, Judith S" sort="Kempfle, Judith S" uniqKey="Kempfle J" first="Judith S." last="Kempfle">Judith S. Kempfle</name><affiliation><nlm:aff id="a22"><institution>Department of Otology and Laryngology, Harvard Medical School</institution>, Boston, Massachusetts 02114,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Kenna, Tony J" sort="Kenna, Tony J" uniqKey="Kenna T" first="Tony J." last="Kenna">Tony J. Kenna</name><affiliation><nlm:aff id="a44"><institution>Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital</institution>, Brisbane, QLD 4102,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Kere, Juha" sort="Kere, Juha" uniqKey="Kere J" first="Juha" last="Kere">Juha Kere</name><affiliation><nlm:aff id="a25"><institution>Department of Biosciences and Nutrition, Karolinska Institutet</institution>, Halsovagen 7-9, SE-141 83 Huddinge,<country>Sweden</country></nlm:aff></affiliation><affiliation><nlm:aff id="a45"><institution>Department of Genetics and Molecular Medicine, King's College London</institution>, Guy’s St Thomas Street, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Khachigian, Levon M" sort="Khachigian, Levon M" uniqKey="Khachigian L" first="Levon M." last="Khachigian">Levon M. Khachigian</name><affiliation><nlm:aff id="a46"><institution>Centre for Vascular Research, University of New South Wales</institution>, Sydney, New South Wales 2052,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="a47"><institution>Vascular Biology and Translational Research, School of Medical Sciences, University of New South Wales</institution>, Sydney, New South Wales 2052,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Kitamura, Toshio" sort="Kitamura, Toshio" uniqKey="Kitamura T" first="Toshio" last="Kitamura">Toshio Kitamura</name><affiliation><nlm:aff id="a48"><institution>Division of Cellular Therapy and Division of Stem Cell Signaling, Institute of Medical Science, University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Klein, Sarah" sort="Klein, Sarah" uniqKey="Klein S" first="Sarah" last="Klein">Sarah Klein</name><affiliation><nlm:aff id="a20"><institution>Institute of Pharmaceutical Sciences, ETH Zurich</institution>, Vladimir-Prelog-Weg 3, HCI H 303, 8093 Zurich,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Klinken, S Peter" sort="Klinken, S Peter" uniqKey="Klinken S" first="S. Peter" last="Klinken">S. Peter Klinken</name><affiliation><nlm:aff id="a49"><institution>Harry Perkins Institute of Medical Research</institution>, Perth, WA 6009,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Knox, Alan J" sort="Knox, Alan J" uniqKey="Knox A" first="Alan J." last="Knox">Alan J. Knox</name><affiliation><nlm:aff id="a50"><institution>Respiratory Medicine, University of Nottingham</institution>, Hucknall Road, Nottingham NG5 1PB,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kojima, Soichi" sort="Kojima, Soichi" uniqKey="Kojima S" first="Soichi" last="Kojima">Soichi Kojima</name><affiliation><nlm:aff id="a39"><institution>RIKEN Center for Life Science Technologies</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Koseki, Haruhiko" sort="Koseki, Haruhiko" uniqKey="Koseki H" first="Haruhiko" last="Koseki">Haruhiko Koseki</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Koyasu, Shigeo" sort="Koyasu, Shigeo" uniqKey="Koyasu S" first="Shigeo" last="Koyasu">Shigeo Koyasu</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Lee, Weonju" sort="Lee, Weonju" uniqKey="Lee W" first="Weonju" last="Lee">Weonju Lee</name><affiliation><nlm:aff id="a51"><institution>Dermatology, School of Medicine Kyungpook National University</institution>, Jung-gu, Daegu 41944,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Lennartsson, Andreas" sort="Lennartsson, Andreas" uniqKey="Lennartsson A" first="Andreas" last="Lennartsson">Andreas Lennartsson</name><affiliation><nlm:aff id="a25"><institution>Department of Biosciences and Nutrition, Karolinska Institutet</institution>, Halsovagen 7-9, SE-141 83 Huddinge,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Mackay Sim, Alan" sort="Mackay Sim, Alan" uniqKey="Mackay Sim A" first="Alan" last="Mackay-Sim">Alan Mackay-Sim</name><affiliation><nlm:aff id="a52"><institution>Griffith University</institution>, Brisbane, Queensland 4111,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Mejhert, Niklas" sort="Mejhert, Niklas" uniqKey="Mejhert N" first="Niklas" last="Mejhert">Niklas Mejhert</name><affiliation><nlm:aff id="a3"><institution>Department of Medicine, Karolinska Institutet</institution>, 141 86, Stockholm,<country>Sweden</country></nlm:aff></affiliation><affiliation><nlm:aff id="a4"><institution>Karolinska University Hospital, Center for Metabolism and Endocrinology</institution>, 141 86, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Mizuno, Yosuke" sort="Mizuno, Yosuke" uniqKey="Mizuno Y" first="Yosuke" last="Mizuno">Yosuke Mizuno</name><affiliation><nlm:aff id="a53"><institution>Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University</institution>, Hidaka, Saitama 350-1241,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Morikawa, Hiromasa" sort="Morikawa, Hiromasa" uniqKey="Morikawa H" first="Hiromasa" last="Morikawa">Hiromasa Morikawa</name><affiliation><nlm:aff id="a38"><institution>Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University</institution>, Suita, Osaka 565-0871,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Morimoto, Mitsuru" sort="Morimoto, Mitsuru" uniqKey="Morimoto M" first="Mitsuru" last="Morimoto">Mitsuru Morimoto</name><affiliation><nlm:aff id="a27"><institution>Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology</institution>, Chuou-ku, Kobe 650-0047,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Moro, Kazuyo" sort="Moro, Kazuyo" uniqKey="Moro K" first="Kazuyo" last="Moro">Kazuyo Moro</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Morris, Kelly J" sort="Morris, Kelly J" uniqKey="Morris K" first="Kelly J." last="Morris">Kelly J. Morris</name><affiliation><nlm:aff id="a32"><institution>Berlin Institute for Medical Systems Biology, Max Delbrueck Center</institution>, Robert Roessle Str.10, 13125 Berlin,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Motohashi, Hozumi" sort="Motohashi, Hozumi" uniqKey="Motohashi H" first="Hozumi" last="Motohashi">Hozumi Motohashi</name><affiliation><nlm:aff id="a54"><institution>Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Mummery, Christine L" sort="Mummery, Christine L" uniqKey="Mummery C" first="Christine L." last="Mummery">Christine L. Mummery</name><affiliation><nlm:aff id="a55"><institution>Anatomy and Embryology, Leiden University Medical Center</institution>, Einthovenweg 20, P.O. Box 9600, 2300 RC Leiden,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Nakachi, Yutaka" sort="Nakachi, Yutaka" uniqKey="Nakachi Y" first="Yutaka" last="Nakachi">Yutaka Nakachi</name><affiliation><nlm:aff id="a53"><institution>Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University</institution>, Hidaka, Saitama 350-1241,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a56"><institution>Division of Translational Research, Research Center for Genomic Medicine, Saitama Medical University</institution>, Hidaka, Saitama 350-1241,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nakahara, Fumio" sort="Nakahara, Fumio" uniqKey="Nakahara F" first="Fumio" last="Nakahara">Fumio Nakahara</name><affiliation><nlm:aff id="a48"><institution>Division of Cellular Therapy and Division of Stem Cell Signaling, Institute of Medical Science, University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nakamura, Toshiyuki" sort="Nakamura, Toshiyuki" uniqKey="Nakamura T" first="Toshiyuki" last="Nakamura">Toshiyuki Nakamura</name><affiliation><nlm:aff id="a42"><institution>Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nakamura, Yukio" sort="Nakamura, Yukio" uniqKey="Nakamura Y" first="Yukio" last="Nakamura">Yukio Nakamura</name><affiliation><nlm:aff id="a57"><institution>Cell Engineering Division, RIKEN BioResource Center</institution>, Tsukuba, Ibaraki 305-0074,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nozaki, Tadasuke" sort="Nozaki, Tadasuke" uniqKey="Nozaki T" first="Tadasuke" last="Nozaki">Tadasuke Nozaki</name><affiliation><nlm:aff id="a58"><institution>Department of Clinical Molecular Genetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences</institution>, Hachioji, Tokyo 192-0392,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ogishima, Soichi" sort="Ogishima, Soichi" uniqKey="Ogishima S" first="Soichi" last="Ogishima">Soichi Ogishima</name><affiliation><nlm:aff id="a59"><institution>Department of Bioclinical Informatics, Tohoku Medical Megabank Organization, Tohoku University</institution>, Sendai, Miyagi 980-8573,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ohkura, Naganari" sort="Ohkura, Naganari" uniqKey="Ohkura N" first="Naganari" last="Ohkura">Naganari Ohkura</name><affiliation><nlm:aff id="a38"><institution>Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University</institution>, Suita, Osaka 565-0871,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ohno, Hiroshi" sort="Ohno, Hiroshi" uniqKey="Ohno H" first="Hiroshi" last="Ohno">Hiroshi Ohno</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ohshima, Mitsuhiro" sort="Ohshima, Mitsuhiro" uniqKey="Ohshima M" first="Mitsuhiro" last="Ohshima">Mitsuhiro Ohshima</name><affiliation><nlm:aff id="a60"><institution>Department of Biochemistry, Ohu University School of Pharmaceutical Sciences</institution>, Koriyama, Fukushima 963-8611<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Okada Hatakeyama, Mariko" sort="Okada Hatakeyama, Mariko" uniqKey="Okada Hatakeyama M" first="Mariko" last="Okada-Hatakeyama">Mariko Okada-Hatakeyama</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a61"><institution>Insitute for Protein Research, Osaka University</institution>, Suita, Osaka 565-0871,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Okazaki, Yasushi" sort="Okazaki, Yasushi" uniqKey="Okazaki Y" first="Yasushi" last="Okazaki">Yasushi Okazaki</name><affiliation><nlm:aff id="a53"><institution>Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University</institution>, Hidaka, Saitama 350-1241,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a56"><institution>Division of Translational Research, Research Center for Genomic Medicine, Saitama Medical University</institution>, Hidaka, Saitama 350-1241,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Orlando, Valerio" sort="Orlando, Valerio" uniqKey="Orlando V" first="Valerio" last="Orlando">Valerio Orlando</name><affiliation><nlm:aff id="a12"><institution>IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64</institution>, 00143 Rome,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="a62"><institution>Environmental Epigenetics Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST)</institution>, Thuwal 23955-6900,<country>Kingdom of Saudi Arabia</country></nlm:aff></affiliation></author><author><name sortKey="Ovchinnikov, Dmitry A" sort="Ovchinnikov, Dmitry A" uniqKey="Ovchinnikov D" first="Dmitry A." last="Ovchinnikov">Dmitry A. Ovchinnikov</name><affiliation><nlm:aff id="a13"><institution>Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland</institution>, Brisbane, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Passier, Robert" sort="Passier, Robert" uniqKey="Passier R" first="Robert" last="Passier">Robert Passier</name><affiliation><nlm:aff id="a55"><institution>Anatomy and Embryology, Leiden University Medical Center</institution>, Einthovenweg 20, P.O. Box 9600, 2300 RC Leiden,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Patrikakis, Margaret" sort="Patrikakis, Margaret" uniqKey="Patrikakis M" first="Margaret" last="Patrikakis">Margaret Patrikakis</name><affiliation><nlm:aff id="a46"><institution>Centre for Vascular Research, University of New South Wales</institution>, Sydney, New South Wales 2052,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Pombo, Ana" sort="Pombo, Ana" uniqKey="Pombo A" first="Ana" last="Pombo">Ana Pombo</name><affiliation><nlm:aff id="a32"><institution>Berlin Institute for Medical Systems Biology, Max Delbrueck Center</institution>, Robert Roessle Str.10, 13125 Berlin,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Pradhan Bhatt, Swati" sort="Pradhan Bhatt, Swati" uniqKey="Pradhan Bhatt S" first="Swati" last="Pradhan-Bhatt">Swati Pradhan-Bhatt</name><affiliation><nlm:aff id="a63"><institution>University of Delaware</institution>, Newark, DE 19716<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Qin, Xian Yang" sort="Qin, Xian Yang" uniqKey="Qin X" first="Xian-Yang" last="Qin">Xian-Yang Qin</name><affiliation><nlm:aff id="a39"><institution>RIKEN Center for Life Science Technologies</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Rehli, Michael" sort="Rehli, Michael" uniqKey="Rehli M" first="Michael" last="Rehli">Michael Rehli</name><affiliation><nlm:aff id="a23"><institution>Department of Internal Medicine III, University Hospital Regensburg</institution>, F.-J.-Strauss Allee 11, D-93053 Regensburg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="a24"><institution>RCI Regensburg Centre for Interventional Immunology, University Hospital Regensburg</institution>, F.-J.-Strauss Allee 11, D-93053 Regensburg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Rizzu, Patrizia" sort="Rizzu, Patrizia" uniqKey="Rizzu P" first="Patrizia" last="Rizzu">Patrizia Rizzu</name><affiliation><nlm:aff id="a41"><institution>German Center for Neurodegenerative Diseases (DZNE)-Tübingen</institution>, Otfried Müller Straße 23, 72076 Tübingen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Roy, Sugata" sort="Roy, Sugata" uniqKey="Roy S" first="Sugata" last="Roy">Sugata Roy</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sajantila, Antti" sort="Sajantila, Antti" uniqKey="Sajantila A" first="Antti" last="Sajantila">Antti Sajantila</name><affiliation><nlm:aff id="a64"><institution>Hjelt Institute, Department of Forensic Medicine, University of Helsinki</institution>, Kytosuontie 11, 003000 Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Sakaguchi, Shimon" sort="Sakaguchi, Shimon" uniqKey="Sakaguchi S" first="Shimon" last="Sakaguchi">Shimon Sakaguchi</name><affiliation><nlm:aff id="a38"><institution>Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University</institution>, Suita, Osaka 565-0871,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sato, Hiroki" sort="Sato, Hiroki" uniqKey="Sato H" first="Hiroki" last="Sato">Hiroki Sato</name><affiliation><nlm:aff id="a42"><institution>Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Satoh, Hironori" sort="Satoh, Hironori" uniqKey="Satoh H" first="Hironori" last="Satoh">Hironori Satoh</name><affiliation><nlm:aff id="a33"><institution>Department of Medical Biochemistry, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Savvi, Suzana" sort="Savvi, Suzana" uniqKey="Savvi S" first="Suzana" last="Savvi">Suzana Savvi</name><affiliation><nlm:aff id="a14"><institution>Division of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a15"><institution>Immunology of Infectious Diseases, Faculty of Health Sciences, South African Medical Research Council (SAMRC), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a16"><institution>International Centre for Genetic Engineering and Biotechnology, Cape Town Component</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation></author><author><name sortKey="Saxena, Alka" sort="Saxena, Alka" uniqKey="Saxena A" first="Alka" last="Saxena">Alka Saxena</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Schmidl, Christian" sort="Schmidl, Christian" uniqKey="Schmidl C" first="Christian" last="Schmidl">Christian Schmidl</name><affiliation><nlm:aff id="a23"><institution>Department of Internal Medicine III, University Hospital Regensburg</institution>, F.-J.-Strauss Allee 11, D-93053 Regensburg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Schneider, Claudio" sort="Schneider, Claudio" uniqKey="Schneider C" first="Claudio" last="Schneider">Claudio Schneider</name><affiliation><nlm:aff id="a65"><institution>Laboratorio Nazionale CIB, Padriciano</institution>, 99 34149, Trieste,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Schulze Tanzil, Gundula G" sort="Schulze Tanzil, Gundula G" uniqKey="Schulze Tanzil G" first="Gundula G." last="Schulze-Tanzil">Gundula G. Schulze-Tanzil</name><affiliation><nlm:aff id="a66"><institution>Department of Orthopedic, Trauma and Reconstructive Surgery, Charite Universitatsmedizin Berlin</institution>, Charitéplatz 1, 10117 Berlin,<country>German</country></nlm:aff></affiliation></author><author><name sortKey="Schwegmann, Anita" sort="Schwegmann, Anita" uniqKey="Schwegmann A" first="Anita" last="Schwegmann">Anita Schwegmann</name><affiliation><nlm:aff id="a14"><institution>Division of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a15"><institution>Immunology of Infectious Diseases, Faculty of Health Sciences, South African Medical Research Council (SAMRC), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a16"><institution>International Centre for Genetic Engineering and Biotechnology, Cape Town Component</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation></author><author><name sortKey="Sheng, Guojun" sort="Sheng, Guojun" uniqKey="Sheng G" first="Guojun" last="Sheng">Guojun Sheng</name><affiliation><nlm:aff id="a67"><institution>International Research Center for Medical Sciences (IRCMS), Kumamoto University</institution>, Chuo-ku, Kumamoto 860-0811,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Shin, Jay W" sort="Shin, Jay W" uniqKey="Shin J" first="Jay W." last="Shin">Jay W. Shin</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sugiyama, Daisuke" sort="Sugiyama, Daisuke" uniqKey="Sugiyama D" first="Daisuke" last="Sugiyama">Daisuke Sugiyama</name><affiliation><nlm:aff id="a68"><institution>Department of Clinical Study, Center for Advanced Medical Innovation, Kyushu University</institution>, Higashi-Ku, Fukuoka 812-8582,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sugiyama, Takaaki" sort="Sugiyama, Takaaki" uniqKey="Sugiyama T" first="Takaaki" last="Sugiyama">Takaaki Sugiyama</name><affiliation><nlm:aff id="a42"><institution>Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Summers, Kim M" sort="Summers, Kim M" uniqKey="Summers K" first="Kim M." last="Summers">Kim M. Summers</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Takahashi, Naoko" sort="Takahashi, Naoko" uniqKey="Takahashi N" first="Naoko" last="Takahashi">Naoko Takahashi</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Takai, Jun" sort="Takai, Jun" uniqKey="Takai J" first="Jun" last="Takai">Jun Takai</name><affiliation><nlm:aff id="a33"><institution>Department of Medical Biochemistry, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Tanaka, Hiroshi" sort="Tanaka, Hiroshi" uniqKey="Tanaka H" first="Hiroshi" last="Tanaka">Hiroshi Tanaka</name><affiliation><nlm:aff id="a28"><institution>Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University</institution>, Bunkyo-ku, Tokyo 113-8510,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Tatsukawa, Hideki" sort="Tatsukawa, Hideki" uniqKey="Tatsukawa H" first="Hideki" last="Tatsukawa">Hideki Tatsukawa</name><affiliation><nlm:aff id="a69"><institution>Graduate School of Pharmaceutical Sciences, Nagoya University</institution>, Nagoya, Aichi 464-8601,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Tomoiu, Andru" sort="Tomoiu, Andru" uniqKey="Tomoiu A" first="Andru" last="Tomoiu">Andru Tomoiu</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Toyoda, Hiroo" sort="Toyoda, Hiroo" uniqKey="Toyoda H" first="Hiroo" last="Toyoda">Hiroo Toyoda</name><affiliation><nlm:aff id="a54"><institution>Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Van De Wetering, Marc" sort="Van De Wetering, Marc" uniqKey="Van De Wetering M" first="Marc" last="Van De Wetering">Marc Van De Wetering</name><affiliation><nlm:aff id="a17"><institution>Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences</institution>, Uppsalalaan 8, 3584 CT Utrecht,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, Linda M" sort="Van Den Berg, Linda M" uniqKey="Van Den Berg L" first="Linda M." last="Van Den Berg">Linda M. Van Den Berg</name><affiliation><nlm:aff id="a34"><institution>Experimental Immunology, Academic Medical Center, University of Amsterdam</institution>, Meibergdreef 9, 1105 AZ Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Verardo, Roberto" sort="Verardo, Roberto" uniqKey="Verardo R" first="Roberto" last="Verardo">Roberto Verardo</name><affiliation><nlm:aff id="a70"><institution>Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie (LNCIB)</institution>, Padriciano 99, 34149 Trieste,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Vijayan, Dipti" sort="Vijayan, Dipti" uniqKey="Vijayan D" first="Dipti" last="Vijayan">Dipti Vijayan</name><affiliation><nlm:aff id="a71"><institution>QIMR Berghofer Medical Research Institute</institution>, Brisbane, QLD 4006,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Wells, Christine A" sort="Wells, Christine A" uniqKey="Wells C" first="Christine A." last="Wells">Christine A. Wells</name><affiliation><nlm:aff id="a72"><institution>Centre for Stem Cell Systems, Department of Anatomy and Neuroscience, MDHS, University of Melbourne</institution>, Melbourne, VIC 3010,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Winteringham, Louise N" sort="Winteringham, Louise N" uniqKey="Winteringham L" first="Louise N." last="Winteringham">Louise N. Winteringham</name><affiliation><nlm:aff id="a49"><institution>Harry Perkins Institute of Medical Research</institution>, Perth, WA 6009,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Wolvetang, Ernst" sort="Wolvetang, Ernst" uniqKey="Wolvetang E" first="Ernst" last="Wolvetang">Ernst Wolvetang</name><affiliation><nlm:aff id="a13"><institution>Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland</institution>, Brisbane, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Yamaguchi, Yoko" sort="Yamaguchi, Yoko" uniqKey="Yamaguchi Y" first="Yoko" last="Yamaguchi">Yoko Yamaguchi</name><affiliation><nlm:aff id="a73"><institution>Department of Biochemistry, Nihon University School of Dentistry</institution>, Chiyoda-ku, Tokyo 101-8310,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Yamamoto, Masayuki" sort="Yamamoto, Masayuki" uniqKey="Yamamoto M" first="Masayuki" last="Yamamoto">Masayuki Yamamoto</name><affiliation><nlm:aff id="a33"><institution>Department of Medical Biochemistry, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Yanagi Mizuochi, Chiyo" sort="Yanagi Mizuochi, Chiyo" uniqKey="Yanagi Mizuochi C" first="Chiyo" last="Yanagi-Mizuochi">Chiyo Yanagi-Mizuochi</name><affiliation><nlm:aff id="a74"><institution>Center for Clinical and Translational Reseach, Kyushu University Hospital</institution>, Higashi-Ku, Fukuoka 812-8582,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Yoneda, Misako" sort="Yoneda, Misako" uniqKey="Yoneda M" first="Misako" last="Yoneda">Misako Yoneda</name><affiliation><nlm:aff id="a42"><institution>Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Yonekura, Yohei" sort="Yonekura, Yohei" uniqKey="Yonekura Y" first="Yohei" last="Yonekura">Yohei Yonekura</name><affiliation><nlm:aff id="a27"><institution>Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology</institution>, Chuou-ku, Kobe 650-0047,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Zhang, Peter G" sort="Zhang, Peter G" uniqKey="Zhang P" first="Peter G." last="Zhang">Peter G. Zhang</name><affiliation><nlm:aff id="a35"><institution>Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia</institution>, Vancouver, British Columbia V5Z 4H4,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Zucchelli, Silvia" sort="Zucchelli, Silvia" uniqKey="Zucchelli S" first="Silvia" last="Zucchelli">Silvia Zucchelli</name><affiliation><nlm:aff id="a36"><institution>Neuroscience, SISSA</institution>, Via Bonomea 265, 34136 Trieste,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Abugessaisa, Imad" sort="Abugessaisa, Imad" uniqKey="Abugessaisa I" first="Imad" last="Abugessaisa">Imad Abugessaisa</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Arner, Erik" sort="Arner, Erik" uniqKey="Arner E" first="Erik" last="Arner">Erik Arner</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Harshbarger, Jayson" sort="Harshbarger, Jayson" uniqKey="Harshbarger J" first="Jayson" last="Harshbarger">Jayson Harshbarger</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kondo, Atsushi" sort="Kondo, Atsushi" uniqKey="Kondo A" first="Atsushi" last="Kondo">Atsushi Kondo</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Lassmann, Timo" sort="Lassmann, Timo" uniqKey="Lassmann T" first="Timo" last="Lassmann">Timo Lassmann</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a75"><institution>Telethon Kids Institute, the University of Western Australia</institution>, Perth, WA,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Lizio, Marina" sort="Lizio, Marina" uniqKey="Lizio M" first="Marina" last="Lizio">Marina Lizio</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sahin, Serkan" sort="Sahin, Serkan" uniqKey="Sahin S" first="Serkan" last="Sahin">Serkan Sahin</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sengstag, Thierry" sort="Sengstag, Thierry" uniqKey="Sengstag T" first="Thierry" last="Sengstag">Thierry Sengstag</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Severin, Jessica" sort="Severin, Jessica" uniqKey="Severin J" first="Jessica" last="Severin">Jessica Severin</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Shimoji, Hisashi" sort="Shimoji, Hisashi" uniqKey="Shimoji H" first="Hisashi" last="Shimoji">Hisashi Shimoji</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a76"><institution>Preventive medicine and applied genomics unit, RIKEN Advanced Center for Computing and Communication</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Suzuki, Masanori" sort="Suzuki, Masanori" uniqKey="Suzuki M" first="Masanori" last="Suzuki">Masanori Suzuki</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Suzuki, Harukazu" sort="Suzuki, Harukazu" uniqKey="Suzuki H" first="Harukazu" last="Suzuki">Harukazu Suzuki</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kawai, Jun" sort="Kawai, Jun" uniqKey="Kawai J" first="Jun" last="Kawai">Jun Kawai</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a77"><institution>RIKEN Preventive Medicine and Diagnosis Innovation Program</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kondo, Naoto" sort="Kondo, Naoto" uniqKey="Kondo N" first="Naoto" last="Kondo">Naoto Kondo</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Itoh, Masayoshi" sort="Itoh, Masayoshi" uniqKey="Itoh M" first="Masayoshi" last="Itoh">Masayoshi Itoh</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a77"><institution>RIKEN Preventive Medicine and Diagnosis Innovation Program</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Daub, Carsten O" sort="Daub, Carsten O" uniqKey="Daub C" first="Carsten O." last="Daub">Carsten O. Daub</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a25"><institution>Department of Biosciences and Nutrition, Karolinska Institutet</institution>, Halsovagen 7-9, SE-141 83 Huddinge,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Kasukawa, Takeya" sort="Kasukawa, Takeya" uniqKey="Kasukawa T" first="Takeya" last="Kasukawa">Takeya Kasukawa</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kawaji, Hideya" sort="Kawaji, Hideya" uniqKey="Kawaji H" first="Hideya" last="Kawaji">Hideya Kawaji</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a76"><institution>Preventive medicine and applied genomics unit, RIKEN Advanced Center for Computing and Communication</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a77"><institution>RIKEN Preventive Medicine and Diagnosis Innovation Program</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Carninci, Piero" sort="Carninci, Piero" uniqKey="Carninci P" first="Piero" last="Carninci">Piero Carninci</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Forrest, Alistair R R" sort="Forrest, Alistair R R" uniqKey="Forrest A" first="Alistair R. R." last="Forrest">Alistair R. R. Forrest</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a49"><institution>Harry Perkins Institute of Medical Research</institution>, Perth, WA 6009,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Hayashizaki, Yoshihide" sort="Hayashizaki, Yoshihide" uniqKey="Hayashizaki Y" first="Yoshihide" last="Hayashizaki">Yoshihide Hayashizaki</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a77"><institution>RIKEN Preventive Medicine and Diagnosis Innovation Program</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28850106</idno><idno type="pmc">5574368</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574368</idno><idno type="RBID">PMC:5574368</idno><idno type="doi">10.1038/sdata.2017.112</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000673</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000673</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">FANTOM5 CAGE profiles of human and mouse samples</title><author><name sortKey="Noguchi, Shuhei" sort="Noguchi, Shuhei" uniqKey="Noguchi S" first="Shuhei" last="Noguchi">Shuhei Noguchi</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Arakawa, Takahiro" sort="Arakawa, Takahiro" uniqKey="Arakawa T" first="Takahiro" last="Arakawa">Takahiro Arakawa</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Fukuda, Shiro" sort="Fukuda, Shiro" uniqKey="Fukuda S" first="Shiro" last="Fukuda">Shiro Fukuda</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Furuno, Masaaki" sort="Furuno, Masaaki" uniqKey="Furuno M" first="Masaaki" last="Furuno">Masaaki Furuno</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Hasegawa, Akira" sort="Hasegawa, Akira" uniqKey="Hasegawa A" first="Akira" last="Hasegawa">Akira Hasegawa</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Hori, Fumi" sort="Hori, Fumi" uniqKey="Hori F" first="Fumi" last="Hori">Fumi Hori</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ishikawa Kato, Sachi" sort="Ishikawa Kato, Sachi" uniqKey="Ishikawa Kato S" first="Sachi" last="Ishikawa-Kato">Sachi Ishikawa-Kato</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kaida, Kaoru" sort="Kaida, Kaoru" uniqKey="Kaida K" first="Kaoru" last="Kaida">Kaoru Kaida</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kaiho, Ai" sort="Kaiho, Ai" uniqKey="Kaiho A" first="Ai" last="Kaiho">Ai Kaiho</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kanamori Katayama, Mutsumi" sort="Kanamori Katayama, Mutsumi" uniqKey="Kanamori Katayama M" first="Mutsumi" last="Kanamori-Katayama">Mutsumi Kanamori-Katayama</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kawashima, Tsugumi" sort="Kawashima, Tsugumi" uniqKey="Kawashima T" first="Tsugumi" last="Kawashima">Tsugumi Kawashima</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kojima, Miki" sort="Kojima, Miki" uniqKey="Kojima M" first="Miki" last="Kojima">Miki Kojima</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kubosaki, Atsutaka" sort="Kubosaki, Atsutaka" uniqKey="Kubosaki A" first="Atsutaka" last="Kubosaki">Atsutaka Kubosaki</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Manabe, Ri Ichiroh" sort="Manabe, Ri Ichiroh" uniqKey="Manabe R" first="Ri-Ichiroh" last="Manabe">Ri-Ichiroh Manabe</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Murata, Mitsuyoshi" sort="Murata, Mitsuyoshi" uniqKey="Murata M" first="Mitsuyoshi" last="Murata">Mitsuyoshi Murata</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nagao Sato, Sayaka" sort="Nagao Sato, Sayaka" uniqKey="Nagao Sato S" first="Sayaka" last="Nagao-Sato">Sayaka Nagao-Sato</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nakazato, Kenichi" sort="Nakazato, Kenichi" uniqKey="Nakazato K" first="Kenichi" last="Nakazato">Kenichi Nakazato</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ninomiya, Noriko" sort="Ninomiya, Noriko" uniqKey="Ninomiya N" first="Noriko" last="Ninomiya">Noriko Ninomiya</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nishiyori Sueki, Hiromi" sort="Nishiyori Sueki, Hiromi" uniqKey="Nishiyori Sueki H" first="Hiromi" last="Nishiyori-Sueki">Hiromi Nishiyori-Sueki</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Noma, Shohei" sort="Noma, Shohei" uniqKey="Noma S" first="Shohei" last="Noma">Shohei Noma</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Saijyo, Eri" sort="Saijyo, Eri" uniqKey="Saijyo E" first="Eri" last="Saijyo">Eri Saijyo</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Saka, Akiko" sort="Saka, Akiko" uniqKey="Saka A" first="Akiko" last="Saka">Akiko Saka</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sakai, Mizuho" sort="Sakai, Mizuho" uniqKey="Sakai M" first="Mizuho" last="Sakai">Mizuho Sakai</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Simon, Christophe" sort="Simon, Christophe" uniqKey="Simon C" first="Christophe" last="Simon">Christophe Simon</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Suzuki, Naoko" sort="Suzuki, Naoko" uniqKey="Suzuki N" first="Naoko" last="Suzuki">Naoko Suzuki</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Tagami, Michihira" sort="Tagami, Michihira" uniqKey="Tagami M" first="Michihira" last="Tagami">Michihira Tagami</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Watanabe, Shoko" sort="Watanabe, Shoko" uniqKey="Watanabe S" first="Shoko" last="Watanabe">Shoko Watanabe</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Yoshida, Shigehiro" sort="Yoshida, Shigehiro" uniqKey="Yoshida S" first="Shigehiro" last="Yoshida">Shigehiro Yoshida</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Arner, Peter" sort="Arner, Peter" uniqKey="Arner P" first="Peter" last="Arner">Peter Arner</name><affiliation><nlm:aff id="a3"><institution>Department of Medicine, Karolinska Institutet</institution>, 141 86, Stockholm,<country>Sweden</country></nlm:aff></affiliation><affiliation><nlm:aff id="a4"><institution>Karolinska University Hospital, Center for Metabolism and Endocrinology</institution>, 141 86, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Axton, Richard A" sort="Axton, Richard A" uniqKey="Axton R" first="Richard A." last="Axton">Richard A. Axton</name><affiliation><nlm:aff id="a5"><institution>Scottish Centre for Regenerative Medicine, University of Edinburgh</institution>, 5 Little France Drive, Edinburgh EH16 4UU,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Babina, Magda" sort="Babina, Magda" uniqKey="Babina M" first="Magda" last="Babina">Magda Babina</name><affiliation><nlm:aff id="a6"><institution>Department of Dermatology and Allergy, Charite University Medicine Berlin</institution>, Charitéplatz 1, 10117 Berlin,<country>German</country></nlm:aff></affiliation></author><author><name sortKey="Baillie, J Kenneth" sort="Baillie, J Kenneth" uniqKey="Baillie J" first="J. Kenneth" last="Baillie">J. Kenneth Baillie</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Barnett, Timothy C" sort="Barnett, Timothy C" uniqKey="Barnett T" first="Timothy C." last="Barnett">Timothy C. Barnett</name><affiliation><nlm:aff id="a8"><institution>Australian Infectious Diseases Research Centre, The University of Queensland</institution>, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="a9"><institution>School of Chemistry and Molecular Biosciences, The University of Queensland</institution>, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Beckhouse, Anthony G" sort="Beckhouse, Anthony G" uniqKey="Beckhouse A" first="Anthony G." last="Beckhouse">Anthony G. Beckhouse</name><affiliation><nlm:aff id="a10"><institution>Bio-Rad Laboratories Pty Ltd</institution>, Hercules, California 94547,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Blumenthal, Antje" sort="Blumenthal, Antje" uniqKey="Blumenthal A" first="Antje" last="Blumenthal">Antje Blumenthal</name><affiliation><nlm:aff id="a11"><institution>The University of Queensland Diamantina Institute, The University of Queensland</institution>, Woolloongabba, QLD 4102<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Bodega, Beatrice" sort="Bodega, Beatrice" uniqKey="Bodega B" first="Beatrice" last="Bodega">Beatrice Bodega</name><affiliation><nlm:aff id="a12"><institution>IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64</institution>, 00143 Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Bonetti, Alessandro" sort="Bonetti, Alessandro" uniqKey="Bonetti A" first="Alessandro" last="Bonetti">Alessandro Bonetti</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Briggs, James" sort="Briggs, James" uniqKey="Briggs J" first="James" last="Briggs">James Briggs</name><affiliation><nlm:aff id="a13"><institution>Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland</institution>, Brisbane, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Brombacher, Frank" sort="Brombacher, Frank" uniqKey="Brombacher F" first="Frank" last="Brombacher">Frank Brombacher</name><affiliation><nlm:aff id="a14"><institution>Division of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a15"><institution>Immunology of Infectious Diseases, Faculty of Health Sciences, South African Medical Research Council (SAMRC), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a16"><institution>International Centre for Genetic Engineering and Biotechnology, Cape Town Component</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation></author><author><name sortKey="Carlisle, Ailsa J" sort="Carlisle, Ailsa J" uniqKey="Carlisle A" first="Ailsa J." last="Carlisle">Ailsa J. Carlisle</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Clevers, Hans C" sort="Clevers, Hans C" uniqKey="Clevers H" first="Hans C." last="Clevers">Hans C. Clevers</name><affiliation><nlm:aff id="a17"><institution>Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences</institution>, Uppsalalaan 8, 3584 CT Utrecht,<country>The Netherlands</country></nlm:aff></affiliation><affiliation><nlm:aff id="a18"><institution>University Medical Centre Utrecht</institution>, Postbus 85500, 3508 GA Utrecht,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Davis, Carrie A" sort="Davis, Carrie A" uniqKey="Davis C" first="Carrie A." last="Davis">Carrie A. Davis</name><affiliation><nlm:aff id="a19"><institution>Genomics, Cold Spring Harbor Laboratory</institution>, Cold Spring Harbor, New York 11797,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name><affiliation><nlm:aff id="a20"><institution>Institute of Pharmaceutical Sciences, ETH Zurich</institution>, Vladimir-Prelog-Weg 3, HCI H 303, 8093 Zurich,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Dohi, Taeko" sort="Dohi, Taeko" uniqKey="Dohi T" first="Taeko" last="Dohi">Taeko Dohi</name><affiliation><nlm:aff id="a21"><institution>Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute National Center for Global Health and Medicine</institution>, Ichikawa, Chiba 272-8516,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Edge, Albert S B" sort="Edge, Albert S B" uniqKey="Edge A" first="Albert S. B." last="Edge">Albert S. B. Edge</name><affiliation><nlm:aff id="a22"><institution>Department of Otology and Laryngology, Harvard Medical School</institution>, Boston, Massachusetts 02114,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Edinger, Matthias" sort="Edinger, Matthias" uniqKey="Edinger M" first="Matthias" last="Edinger">Matthias Edinger</name><affiliation><nlm:aff id="a23"><institution>Department of Internal Medicine III, University Hospital Regensburg</institution>, F.-J.-Strauss Allee 11, D-93053 Regensburg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="a24"><institution>RCI Regensburg Centre for Interventional Immunology, University Hospital Regensburg</institution>, F.-J.-Strauss Allee 11, D-93053 Regensburg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ehrlund, Anna" sort="Ehrlund, Anna" uniqKey="Ehrlund A" first="Anna" last="Ehrlund">Anna Ehrlund</name><affiliation><nlm:aff id="a3"><institution>Department of Medicine, Karolinska Institutet</institution>, 141 86, Stockholm,<country>Sweden</country></nlm:aff></affiliation><affiliation><nlm:aff id="a4"><institution>Karolinska University Hospital, Center for Metabolism and Endocrinology</institution>, 141 86, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Ekwall, Karl" sort="Ekwall, Karl" uniqKey="Ekwall K" first="Karl" last="Ekwall">Karl Ekwall</name><affiliation><nlm:aff id="a25"><institution>Department of Biosciences and Nutrition, Karolinska Institutet</institution>, Halsovagen 7-9, SE-141 83 Huddinge,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Endoh, Mitsuhiro" sort="Endoh, Mitsuhiro" uniqKey="Endoh M" first="Mitsuhiro" last="Endoh">Mitsuhiro Endoh</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Enomoto, Hideki" sort="Enomoto, Hideki" uniqKey="Enomoto H" first="Hideki" last="Enomoto">Hideki Enomoto</name><affiliation><nlm:aff id="a27"><institution>Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology</institution>, Chuou-ku, Kobe 650-0047,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Eslami, Afsaneh" sort="Eslami, Afsaneh" uniqKey="Eslami A" first="Afsaneh" last="Eslami">Afsaneh Eslami</name><affiliation><nlm:aff id="a28"><institution>Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University</institution>, Bunkyo-ku, Tokyo 113-8510,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Fagiolini, Michela" sort="Fagiolini, Michela" uniqKey="Fagiolini M" first="Michela" last="Fagiolini">Michela Fagiolini</name><affiliation><nlm:aff id="a29"><institution>F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Fairbairn, Lynsey" sort="Fairbairn, Lynsey" uniqKey="Fairbairn L" first="Lynsey" last="Fairbairn">Lynsey Fairbairn</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Farach Carson, Mary C" sort="Farach Carson, Mary C" uniqKey="Farach Carson M" first="Mary C." last="Farach-Carson">Mary C. Farach-Carson</name><affiliation><nlm:aff id="a30"><institution>The University of Texas Health Science Center at Houston</institution>, Houston, TX 77251-1892,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Faulkner, Geoffrey J" sort="Faulkner, Geoffrey J" uniqKey="Faulkner G" first="Geoffrey J." last="Faulkner">Geoffrey J. Faulkner</name><affiliation><nlm:aff id="a31"><institution>Cancer Biology Program, Mater Medical Research Institute</institution>, South Brisbane, Queensland 4101,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Ferrai, Carmelo" sort="Ferrai, Carmelo" uniqKey="Ferrai C" first="Carmelo" last="Ferrai">Carmelo Ferrai</name><affiliation><nlm:aff id="a32"><institution>Berlin Institute for Medical Systems Biology, Max Delbrueck Center</institution>, Robert Roessle Str.10, 13125 Berlin,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Fisher, Malcolm E" sort="Fisher, Malcolm E" uniqKey="Fisher M" first="Malcolm E." last="Fisher">Malcolm E. Fisher</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Forrester, Lesley M" sort="Forrester, Lesley M" uniqKey="Forrester L" first="Lesley M." last="Forrester">Lesley M. Forrester</name><affiliation><nlm:aff id="a5"><institution>Scottish Centre for Regenerative Medicine, University of Edinburgh</institution>, 5 Little France Drive, Edinburgh EH16 4UU,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Fujita, Rie" sort="Fujita, Rie" uniqKey="Fujita R" first="Rie" last="Fujita">Rie Fujita</name><affiliation><nlm:aff id="a33"><institution>Department of Medical Biochemistry, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Furusawa, Jun Ichi" sort="Furusawa, Jun Ichi" uniqKey="Furusawa J" first="Jun-Ichi" last="Furusawa">Jun-Ichi Furusawa</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Geijtenbeek, Teunis B" sort="Geijtenbeek, Teunis B" uniqKey="Geijtenbeek T" first="Teunis B." last="Geijtenbeek">Teunis B. Geijtenbeek</name><affiliation><nlm:aff id="a34"><institution>Experimental Immunology, Academic Medical Center, University of Amsterdam</institution>, Meibergdreef 9, 1105 AZ Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Gingeras, Thomas" sort="Gingeras, Thomas" uniqKey="Gingeras T" first="Thomas" last="Gingeras">Thomas Gingeras</name><affiliation><nlm:aff id="a19"><institution>Genomics, Cold Spring Harbor Laboratory</institution>, Cold Spring Harbor, New York 11797,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Goldowitz, Daniel" sort="Goldowitz, Daniel" uniqKey="Goldowitz D" first="Daniel" last="Goldowitz">Daniel Goldowitz</name><affiliation><nlm:aff id="a35"><institution>Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia</institution>, Vancouver, British Columbia V5Z 4H4,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Guhl, Sven" sort="Guhl, Sven" uniqKey="Guhl S" first="Sven" last="Guhl">Sven Guhl</name><affiliation><nlm:aff id="a6"><institution>Department of Dermatology and Allergy, Charite University Medicine Berlin</institution>, Charitéplatz 1, 10117 Berlin,<country>German</country></nlm:aff></affiliation></author><author><name sortKey="Guler, Reto" sort="Guler, Reto" uniqKey="Guler R" first="Reto" last="Guler">Reto Guler</name><affiliation><nlm:aff id="a14"><institution>Division of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a15"><institution>Immunology of Infectious Diseases, Faculty of Health Sciences, South African Medical Research Council (SAMRC), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a16"><institution>International Centre for Genetic Engineering and Biotechnology, Cape Town Component</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation></author><author><name sortKey="Gustincich, Stefano" sort="Gustincich, Stefano" uniqKey="Gustincich S" first="Stefano" last="Gustincich">Stefano Gustincich</name><affiliation><nlm:aff id="a36"><institution>Neuroscience, SISSA</institution>, Via Bonomea 265, 34136 Trieste,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="a37"><institution>Department of Neuroscience and Brian Technologies, Italian Istitute of Technology</institution>, Via Morego 30, Genova,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Ha, Thomas J" sort="Ha, Thomas J" uniqKey="Ha T" first="Thomas J." last="Ha">Thomas J. Ha</name><affiliation><nlm:aff id="a35"><institution>Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia</institution>, Vancouver, British Columbia V5Z 4H4,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Hamaguchi, Masahide" sort="Hamaguchi, Masahide" uniqKey="Hamaguchi M" first="Masahide" last="Hamaguchi">Masahide Hamaguchi</name><affiliation><nlm:aff id="a38"><institution>Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University</institution>, Suita, Osaka 565-0871,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Hara, Mitsuko" sort="Hara, Mitsuko" uniqKey="Hara M" first="Mitsuko" last="Hara">Mitsuko Hara</name><affiliation><nlm:aff id="a39"><institution>RIKEN Center for Life Science Technologies</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Hasegawa, Yuki" sort="Hasegawa, Yuki" uniqKey="Hasegawa Y" first="Yuki" last="Hasegawa">Yuki Hasegawa</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Herlyn, Meenhard" sort="Herlyn, Meenhard" uniqKey="Herlyn M" first="Meenhard" last="Herlyn">Meenhard Herlyn</name><affiliation><nlm:aff id="a40"><institution>Melanoma Research Center, The Wistar Institute</institution>, Philadelphia, Pennsylvania 19104,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name><affiliation><nlm:aff id="a41"><institution>German Center for Neurodegenerative Diseases (DZNE)-Tübingen</institution>, Otfried Müller Straße 23, 72076 Tübingen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Hitchens, Kelly J" sort="Hitchens, Kelly J" uniqKey="Hitchens K" first="Kelly J." last="Hitchens">Kelly J. Hitchens</name><affiliation><nlm:aff id="a8"><institution>Australian Infectious Diseases Research Centre, The University of Queensland</institution>, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="a13"><institution>Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland</institution>, Brisbane, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Hume, David A" sort="Hume, David A" uniqKey="Hume D" first="David A." last="Hume">David A. Hume</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Ikawa, Tomokatsu" sort="Ikawa, Tomokatsu" uniqKey="Ikawa T" first="Tomokatsu" last="Ikawa">Tomokatsu Ikawa</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ishizu, Yuri" sort="Ishizu, Yuri" uniqKey="Ishizu Y" first="Yuri" last="Ishizu">Yuri Ishizu</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kai, Chieko" sort="Kai, Chieko" uniqKey="Kai C" first="Chieko" last="Kai">Chieko Kai</name><affiliation><nlm:aff id="a42"><institution>Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a43"><institution>International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kawamoto, Hiroshi" sort="Kawamoto, Hiroshi" uniqKey="Kawamoto H" first="Hiroshi" last="Kawamoto">Hiroshi Kawamoto</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kawamura, Yuki I" sort="Kawamura, Yuki I" uniqKey="Kawamura Y" first="Yuki I." last="Kawamura">Yuki I. Kawamura</name><affiliation><nlm:aff id="a21"><institution>Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute National Center for Global Health and Medicine</institution>, Ichikawa, Chiba 272-8516,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kempfle, Judith S" sort="Kempfle, Judith S" uniqKey="Kempfle J" first="Judith S." last="Kempfle">Judith S. Kempfle</name><affiliation><nlm:aff id="a22"><institution>Department of Otology and Laryngology, Harvard Medical School</institution>, Boston, Massachusetts 02114,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Kenna, Tony J" sort="Kenna, Tony J" uniqKey="Kenna T" first="Tony J." last="Kenna">Tony J. Kenna</name><affiliation><nlm:aff id="a44"><institution>Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital</institution>, Brisbane, QLD 4102,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Kere, Juha" sort="Kere, Juha" uniqKey="Kere J" first="Juha" last="Kere">Juha Kere</name><affiliation><nlm:aff id="a25"><institution>Department of Biosciences and Nutrition, Karolinska Institutet</institution>, Halsovagen 7-9, SE-141 83 Huddinge,<country>Sweden</country></nlm:aff></affiliation><affiliation><nlm:aff id="a45"><institution>Department of Genetics and Molecular Medicine, King's College London</institution>, Guy’s St Thomas Street, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Khachigian, Levon M" sort="Khachigian, Levon M" uniqKey="Khachigian L" first="Levon M." last="Khachigian">Levon M. Khachigian</name><affiliation><nlm:aff id="a46"><institution>Centre for Vascular Research, University of New South Wales</institution>, Sydney, New South Wales 2052,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="a47"><institution>Vascular Biology and Translational Research, School of Medical Sciences, University of New South Wales</institution>, Sydney, New South Wales 2052,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Kitamura, Toshio" sort="Kitamura, Toshio" uniqKey="Kitamura T" first="Toshio" last="Kitamura">Toshio Kitamura</name><affiliation><nlm:aff id="a48"><institution>Division of Cellular Therapy and Division of Stem Cell Signaling, Institute of Medical Science, University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Klein, Sarah" sort="Klein, Sarah" uniqKey="Klein S" first="Sarah" last="Klein">Sarah Klein</name><affiliation><nlm:aff id="a20"><institution>Institute of Pharmaceutical Sciences, ETH Zurich</institution>, Vladimir-Prelog-Weg 3, HCI H 303, 8093 Zurich,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Klinken, S Peter" sort="Klinken, S Peter" uniqKey="Klinken S" first="S. Peter" last="Klinken">S. Peter Klinken</name><affiliation><nlm:aff id="a49"><institution>Harry Perkins Institute of Medical Research</institution>, Perth, WA 6009,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Knox, Alan J" sort="Knox, Alan J" uniqKey="Knox A" first="Alan J." last="Knox">Alan J. Knox</name><affiliation><nlm:aff id="a50"><institution>Respiratory Medicine, University of Nottingham</institution>, Hucknall Road, Nottingham NG5 1PB,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kojima, Soichi" sort="Kojima, Soichi" uniqKey="Kojima S" first="Soichi" last="Kojima">Soichi Kojima</name><affiliation><nlm:aff id="a39"><institution>RIKEN Center for Life Science Technologies</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Koseki, Haruhiko" sort="Koseki, Haruhiko" uniqKey="Koseki H" first="Haruhiko" last="Koseki">Haruhiko Koseki</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Koyasu, Shigeo" sort="Koyasu, Shigeo" uniqKey="Koyasu S" first="Shigeo" last="Koyasu">Shigeo Koyasu</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Lee, Weonju" sort="Lee, Weonju" uniqKey="Lee W" first="Weonju" last="Lee">Weonju Lee</name><affiliation><nlm:aff id="a51"><institution>Dermatology, School of Medicine Kyungpook National University</institution>, Jung-gu, Daegu 41944,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Lennartsson, Andreas" sort="Lennartsson, Andreas" uniqKey="Lennartsson A" first="Andreas" last="Lennartsson">Andreas Lennartsson</name><affiliation><nlm:aff id="a25"><institution>Department of Biosciences and Nutrition, Karolinska Institutet</institution>, Halsovagen 7-9, SE-141 83 Huddinge,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Mackay Sim, Alan" sort="Mackay Sim, Alan" uniqKey="Mackay Sim A" first="Alan" last="Mackay-Sim">Alan Mackay-Sim</name><affiliation><nlm:aff id="a52"><institution>Griffith University</institution>, Brisbane, Queensland 4111,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Mejhert, Niklas" sort="Mejhert, Niklas" uniqKey="Mejhert N" first="Niklas" last="Mejhert">Niklas Mejhert</name><affiliation><nlm:aff id="a3"><institution>Department of Medicine, Karolinska Institutet</institution>, 141 86, Stockholm,<country>Sweden</country></nlm:aff></affiliation><affiliation><nlm:aff id="a4"><institution>Karolinska University Hospital, Center for Metabolism and Endocrinology</institution>, 141 86, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Mizuno, Yosuke" sort="Mizuno, Yosuke" uniqKey="Mizuno Y" first="Yosuke" last="Mizuno">Yosuke Mizuno</name><affiliation><nlm:aff id="a53"><institution>Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University</institution>, Hidaka, Saitama 350-1241,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Morikawa, Hiromasa" sort="Morikawa, Hiromasa" uniqKey="Morikawa H" first="Hiromasa" last="Morikawa">Hiromasa Morikawa</name><affiliation><nlm:aff id="a38"><institution>Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University</institution>, Suita, Osaka 565-0871,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Morimoto, Mitsuru" sort="Morimoto, Mitsuru" uniqKey="Morimoto M" first="Mitsuru" last="Morimoto">Mitsuru Morimoto</name><affiliation><nlm:aff id="a27"><institution>Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology</institution>, Chuou-ku, Kobe 650-0047,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Moro, Kazuyo" sort="Moro, Kazuyo" uniqKey="Moro K" first="Kazuyo" last="Moro">Kazuyo Moro</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Morris, Kelly J" sort="Morris, Kelly J" uniqKey="Morris K" first="Kelly J." last="Morris">Kelly J. Morris</name><affiliation><nlm:aff id="a32"><institution>Berlin Institute for Medical Systems Biology, Max Delbrueck Center</institution>, Robert Roessle Str.10, 13125 Berlin,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Motohashi, Hozumi" sort="Motohashi, Hozumi" uniqKey="Motohashi H" first="Hozumi" last="Motohashi">Hozumi Motohashi</name><affiliation><nlm:aff id="a54"><institution>Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Mummery, Christine L" sort="Mummery, Christine L" uniqKey="Mummery C" first="Christine L." last="Mummery">Christine L. Mummery</name><affiliation><nlm:aff id="a55"><institution>Anatomy and Embryology, Leiden University Medical Center</institution>, Einthovenweg 20, P.O. Box 9600, 2300 RC Leiden,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Nakachi, Yutaka" sort="Nakachi, Yutaka" uniqKey="Nakachi Y" first="Yutaka" last="Nakachi">Yutaka Nakachi</name><affiliation><nlm:aff id="a53"><institution>Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University</institution>, Hidaka, Saitama 350-1241,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a56"><institution>Division of Translational Research, Research Center for Genomic Medicine, Saitama Medical University</institution>, Hidaka, Saitama 350-1241,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nakahara, Fumio" sort="Nakahara, Fumio" uniqKey="Nakahara F" first="Fumio" last="Nakahara">Fumio Nakahara</name><affiliation><nlm:aff id="a48"><institution>Division of Cellular Therapy and Division of Stem Cell Signaling, Institute of Medical Science, University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nakamura, Toshiyuki" sort="Nakamura, Toshiyuki" uniqKey="Nakamura T" first="Toshiyuki" last="Nakamura">Toshiyuki Nakamura</name><affiliation><nlm:aff id="a42"><institution>Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nakamura, Yukio" sort="Nakamura, Yukio" uniqKey="Nakamura Y" first="Yukio" last="Nakamura">Yukio Nakamura</name><affiliation><nlm:aff id="a57"><institution>Cell Engineering Division, RIKEN BioResource Center</institution>, Tsukuba, Ibaraki 305-0074,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Nozaki, Tadasuke" sort="Nozaki, Tadasuke" uniqKey="Nozaki T" first="Tadasuke" last="Nozaki">Tadasuke Nozaki</name><affiliation><nlm:aff id="a58"><institution>Department of Clinical Molecular Genetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences</institution>, Hachioji, Tokyo 192-0392,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ogishima, Soichi" sort="Ogishima, Soichi" uniqKey="Ogishima S" first="Soichi" last="Ogishima">Soichi Ogishima</name><affiliation><nlm:aff id="a59"><institution>Department of Bioclinical Informatics, Tohoku Medical Megabank Organization, Tohoku University</institution>, Sendai, Miyagi 980-8573,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ohkura, Naganari" sort="Ohkura, Naganari" uniqKey="Ohkura N" first="Naganari" last="Ohkura">Naganari Ohkura</name><affiliation><nlm:aff id="a38"><institution>Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University</institution>, Suita, Osaka 565-0871,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ohno, Hiroshi" sort="Ohno, Hiroshi" uniqKey="Ohno H" first="Hiroshi" last="Ohno">Hiroshi Ohno</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ohshima, Mitsuhiro" sort="Ohshima, Mitsuhiro" uniqKey="Ohshima M" first="Mitsuhiro" last="Ohshima">Mitsuhiro Ohshima</name><affiliation><nlm:aff id="a60"><institution>Department of Biochemistry, Ohu University School of Pharmaceutical Sciences</institution>, Koriyama, Fukushima 963-8611<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Okada Hatakeyama, Mariko" sort="Okada Hatakeyama, Mariko" uniqKey="Okada Hatakeyama M" first="Mariko" last="Okada-Hatakeyama">Mariko Okada-Hatakeyama</name><affiliation><nlm:aff id="a26"><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a61"><institution>Insitute for Protein Research, Osaka University</institution>, Suita, Osaka 565-0871,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Okazaki, Yasushi" sort="Okazaki, Yasushi" uniqKey="Okazaki Y" first="Yasushi" last="Okazaki">Yasushi Okazaki</name><affiliation><nlm:aff id="a53"><institution>Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University</institution>, Hidaka, Saitama 350-1241,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a56"><institution>Division of Translational Research, Research Center for Genomic Medicine, Saitama Medical University</institution>, Hidaka, Saitama 350-1241,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Orlando, Valerio" sort="Orlando, Valerio" uniqKey="Orlando V" first="Valerio" last="Orlando">Valerio Orlando</name><affiliation><nlm:aff id="a12"><institution>IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64</institution>, 00143 Rome,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="a62"><institution>Environmental Epigenetics Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST)</institution>, Thuwal 23955-6900,<country>Kingdom of Saudi Arabia</country></nlm:aff></affiliation></author><author><name sortKey="Ovchinnikov, Dmitry A" sort="Ovchinnikov, Dmitry A" uniqKey="Ovchinnikov D" first="Dmitry A." last="Ovchinnikov">Dmitry A. Ovchinnikov</name><affiliation><nlm:aff id="a13"><institution>Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland</institution>, Brisbane, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Passier, Robert" sort="Passier, Robert" uniqKey="Passier R" first="Robert" last="Passier">Robert Passier</name><affiliation><nlm:aff id="a55"><institution>Anatomy and Embryology, Leiden University Medical Center</institution>, Einthovenweg 20, P.O. Box 9600, 2300 RC Leiden,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Patrikakis, Margaret" sort="Patrikakis, Margaret" uniqKey="Patrikakis M" first="Margaret" last="Patrikakis">Margaret Patrikakis</name><affiliation><nlm:aff id="a46"><institution>Centre for Vascular Research, University of New South Wales</institution>, Sydney, New South Wales 2052,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Pombo, Ana" sort="Pombo, Ana" uniqKey="Pombo A" first="Ana" last="Pombo">Ana Pombo</name><affiliation><nlm:aff id="a32"><institution>Berlin Institute for Medical Systems Biology, Max Delbrueck Center</institution>, Robert Roessle Str.10, 13125 Berlin,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Pradhan Bhatt, Swati" sort="Pradhan Bhatt, Swati" uniqKey="Pradhan Bhatt S" first="Swati" last="Pradhan-Bhatt">Swati Pradhan-Bhatt</name><affiliation><nlm:aff id="a63"><institution>University of Delaware</institution>, Newark, DE 19716<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Qin, Xian Yang" sort="Qin, Xian Yang" uniqKey="Qin X" first="Xian-Yang" last="Qin">Xian-Yang Qin</name><affiliation><nlm:aff id="a39"><institution>RIKEN Center for Life Science Technologies</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Rehli, Michael" sort="Rehli, Michael" uniqKey="Rehli M" first="Michael" last="Rehli">Michael Rehli</name><affiliation><nlm:aff id="a23"><institution>Department of Internal Medicine III, University Hospital Regensburg</institution>, F.-J.-Strauss Allee 11, D-93053 Regensburg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="a24"><institution>RCI Regensburg Centre for Interventional Immunology, University Hospital Regensburg</institution>, F.-J.-Strauss Allee 11, D-93053 Regensburg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Rizzu, Patrizia" sort="Rizzu, Patrizia" uniqKey="Rizzu P" first="Patrizia" last="Rizzu">Patrizia Rizzu</name><affiliation><nlm:aff id="a41"><institution>German Center for Neurodegenerative Diseases (DZNE)-Tübingen</institution>, Otfried Müller Straße 23, 72076 Tübingen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Roy, Sugata" sort="Roy, Sugata" uniqKey="Roy S" first="Sugata" last="Roy">Sugata Roy</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sajantila, Antti" sort="Sajantila, Antti" uniqKey="Sajantila A" first="Antti" last="Sajantila">Antti Sajantila</name><affiliation><nlm:aff id="a64"><institution>Hjelt Institute, Department of Forensic Medicine, University of Helsinki</institution>, Kytosuontie 11, 003000 Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Sakaguchi, Shimon" sort="Sakaguchi, Shimon" uniqKey="Sakaguchi S" first="Shimon" last="Sakaguchi">Shimon Sakaguchi</name><affiliation><nlm:aff id="a38"><institution>Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University</institution>, Suita, Osaka 565-0871,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sato, Hiroki" sort="Sato, Hiroki" uniqKey="Sato H" first="Hiroki" last="Sato">Hiroki Sato</name><affiliation><nlm:aff id="a42"><institution>Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Satoh, Hironori" sort="Satoh, Hironori" uniqKey="Satoh H" first="Hironori" last="Satoh">Hironori Satoh</name><affiliation><nlm:aff id="a33"><institution>Department of Medical Biochemistry, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Savvi, Suzana" sort="Savvi, Suzana" uniqKey="Savvi S" first="Suzana" last="Savvi">Suzana Savvi</name><affiliation><nlm:aff id="a14"><institution>Division of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a15"><institution>Immunology of Infectious Diseases, Faculty of Health Sciences, South African Medical Research Council (SAMRC), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a16"><institution>International Centre for Genetic Engineering and Biotechnology, Cape Town Component</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation></author><author><name sortKey="Saxena, Alka" sort="Saxena, Alka" uniqKey="Saxena A" first="Alka" last="Saxena">Alka Saxena</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Schmidl, Christian" sort="Schmidl, Christian" uniqKey="Schmidl C" first="Christian" last="Schmidl">Christian Schmidl</name><affiliation><nlm:aff id="a23"><institution>Department of Internal Medicine III, University Hospital Regensburg</institution>, F.-J.-Strauss Allee 11, D-93053 Regensburg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Schneider, Claudio" sort="Schneider, Claudio" uniqKey="Schneider C" first="Claudio" last="Schneider">Claudio Schneider</name><affiliation><nlm:aff id="a65"><institution>Laboratorio Nazionale CIB, Padriciano</institution>, 99 34149, Trieste,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Schulze Tanzil, Gundula G" sort="Schulze Tanzil, Gundula G" uniqKey="Schulze Tanzil G" first="Gundula G." last="Schulze-Tanzil">Gundula G. Schulze-Tanzil</name><affiliation><nlm:aff id="a66"><institution>Department of Orthopedic, Trauma and Reconstructive Surgery, Charite Universitatsmedizin Berlin</institution>, Charitéplatz 1, 10117 Berlin,<country>German</country></nlm:aff></affiliation></author><author><name sortKey="Schwegmann, Anita" sort="Schwegmann, Anita" uniqKey="Schwegmann A" first="Anita" last="Schwegmann">Anita Schwegmann</name><affiliation><nlm:aff id="a14"><institution>Division of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a15"><institution>Immunology of Infectious Diseases, Faculty of Health Sciences, South African Medical Research Council (SAMRC), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation><affiliation><nlm:aff id="a16"><institution>International Centre for Genetic Engineering and Biotechnology, Cape Town Component</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></nlm:aff></affiliation></author><author><name sortKey="Sheng, Guojun" sort="Sheng, Guojun" uniqKey="Sheng G" first="Guojun" last="Sheng">Guojun Sheng</name><affiliation><nlm:aff id="a67"><institution>International Research Center for Medical Sciences (IRCMS), Kumamoto University</institution>, Chuo-ku, Kumamoto 860-0811,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Shin, Jay W" sort="Shin, Jay W" uniqKey="Shin J" first="Jay W." last="Shin">Jay W. Shin</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sugiyama, Daisuke" sort="Sugiyama, Daisuke" uniqKey="Sugiyama D" first="Daisuke" last="Sugiyama">Daisuke Sugiyama</name><affiliation><nlm:aff id="a68"><institution>Department of Clinical Study, Center for Advanced Medical Innovation, Kyushu University</institution>, Higashi-Ku, Fukuoka 812-8582,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sugiyama, Takaaki" sort="Sugiyama, Takaaki" uniqKey="Sugiyama T" first="Takaaki" last="Sugiyama">Takaaki Sugiyama</name><affiliation><nlm:aff id="a42"><institution>Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Summers, Kim M" sort="Summers, Kim M" uniqKey="Summers K" first="Kim M." last="Summers">Kim M. Summers</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Takahashi, Naoko" sort="Takahashi, Naoko" uniqKey="Takahashi N" first="Naoko" last="Takahashi">Naoko Takahashi</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Takai, Jun" sort="Takai, Jun" uniqKey="Takai J" first="Jun" last="Takai">Jun Takai</name><affiliation><nlm:aff id="a33"><institution>Department of Medical Biochemistry, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Tanaka, Hiroshi" sort="Tanaka, Hiroshi" uniqKey="Tanaka H" first="Hiroshi" last="Tanaka">Hiroshi Tanaka</name><affiliation><nlm:aff id="a28"><institution>Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University</institution>, Bunkyo-ku, Tokyo 113-8510,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Tatsukawa, Hideki" sort="Tatsukawa, Hideki" uniqKey="Tatsukawa H" first="Hideki" last="Tatsukawa">Hideki Tatsukawa</name><affiliation><nlm:aff id="a69"><institution>Graduate School of Pharmaceutical Sciences, Nagoya University</institution>, Nagoya, Aichi 464-8601,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Tomoiu, Andru" sort="Tomoiu, Andru" uniqKey="Tomoiu A" first="Andru" last="Tomoiu">Andru Tomoiu</name><affiliation><nlm:aff id="a7"><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Toyoda, Hiroo" sort="Toyoda, Hiroo" uniqKey="Toyoda H" first="Hiroo" last="Toyoda">Hiroo Toyoda</name><affiliation><nlm:aff id="a54"><institution>Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Van De Wetering, Marc" sort="Van De Wetering, Marc" uniqKey="Van De Wetering M" first="Marc" last="Van De Wetering">Marc Van De Wetering</name><affiliation><nlm:aff id="a17"><institution>Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences</institution>, Uppsalalaan 8, 3584 CT Utrecht,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, Linda M" sort="Van Den Berg, Linda M" uniqKey="Van Den Berg L" first="Linda M." last="Van Den Berg">Linda M. Van Den Berg</name><affiliation><nlm:aff id="a34"><institution>Experimental Immunology, Academic Medical Center, University of Amsterdam</institution>, Meibergdreef 9, 1105 AZ Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Verardo, Roberto" sort="Verardo, Roberto" uniqKey="Verardo R" first="Roberto" last="Verardo">Roberto Verardo</name><affiliation><nlm:aff id="a70"><institution>Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie (LNCIB)</institution>, Padriciano 99, 34149 Trieste,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Vijayan, Dipti" sort="Vijayan, Dipti" uniqKey="Vijayan D" first="Dipti" last="Vijayan">Dipti Vijayan</name><affiliation><nlm:aff id="a71"><institution>QIMR Berghofer Medical Research Institute</institution>, Brisbane, QLD 4006,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Wells, Christine A" sort="Wells, Christine A" uniqKey="Wells C" first="Christine A." last="Wells">Christine A. Wells</name><affiliation><nlm:aff id="a72"><institution>Centre for Stem Cell Systems, Department of Anatomy and Neuroscience, MDHS, University of Melbourne</institution>, Melbourne, VIC 3010,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Winteringham, Louise N" sort="Winteringham, Louise N" uniqKey="Winteringham L" first="Louise N." last="Winteringham">Louise N. Winteringham</name><affiliation><nlm:aff id="a49"><institution>Harry Perkins Institute of Medical Research</institution>, Perth, WA 6009,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Wolvetang, Ernst" sort="Wolvetang, Ernst" uniqKey="Wolvetang E" first="Ernst" last="Wolvetang">Ernst Wolvetang</name><affiliation><nlm:aff id="a13"><institution>Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland</institution>, Brisbane, St Lucia, QLD 4072,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Yamaguchi, Yoko" sort="Yamaguchi, Yoko" uniqKey="Yamaguchi Y" first="Yoko" last="Yamaguchi">Yoko Yamaguchi</name><affiliation><nlm:aff id="a73"><institution>Department of Biochemistry, Nihon University School of Dentistry</institution>, Chiyoda-ku, Tokyo 101-8310,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Yamamoto, Masayuki" sort="Yamamoto, Masayuki" uniqKey="Yamamoto M" first="Masayuki" last="Yamamoto">Masayuki Yamamoto</name><affiliation><nlm:aff id="a33"><institution>Department of Medical Biochemistry, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Yanagi Mizuochi, Chiyo" sort="Yanagi Mizuochi, Chiyo" uniqKey="Yanagi Mizuochi C" first="Chiyo" last="Yanagi-Mizuochi">Chiyo Yanagi-Mizuochi</name><affiliation><nlm:aff id="a74"><institution>Center for Clinical and Translational Reseach, Kyushu University Hospital</institution>, Higashi-Ku, Fukuoka 812-8582,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Yoneda, Misako" sort="Yoneda, Misako" uniqKey="Yoneda M" first="Misako" last="Yoneda">Misako Yoneda</name><affiliation><nlm:aff id="a42"><institution>Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Yonekura, Yohei" sort="Yonekura, Yohei" uniqKey="Yonekura Y" first="Yohei" last="Yonekura">Yohei Yonekura</name><affiliation><nlm:aff id="a27"><institution>Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology</institution>, Chuou-ku, Kobe 650-0047,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Zhang, Peter G" sort="Zhang, Peter G" uniqKey="Zhang P" first="Peter G." last="Zhang">Peter G. Zhang</name><affiliation><nlm:aff id="a35"><institution>Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia</institution>, Vancouver, British Columbia V5Z 4H4,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Zucchelli, Silvia" sort="Zucchelli, Silvia" uniqKey="Zucchelli S" first="Silvia" last="Zucchelli">Silvia Zucchelli</name><affiliation><nlm:aff id="a36"><institution>Neuroscience, SISSA</institution>, Via Bonomea 265, 34136 Trieste,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Abugessaisa, Imad" sort="Abugessaisa, Imad" uniqKey="Abugessaisa I" first="Imad" last="Abugessaisa">Imad Abugessaisa</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Arner, Erik" sort="Arner, Erik" uniqKey="Arner E" first="Erik" last="Arner">Erik Arner</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Harshbarger, Jayson" sort="Harshbarger, Jayson" uniqKey="Harshbarger J" first="Jayson" last="Harshbarger">Jayson Harshbarger</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kondo, Atsushi" sort="Kondo, Atsushi" uniqKey="Kondo A" first="Atsushi" last="Kondo">Atsushi Kondo</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Lassmann, Timo" sort="Lassmann, Timo" uniqKey="Lassmann T" first="Timo" last="Lassmann">Timo Lassmann</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a75"><institution>Telethon Kids Institute, the University of Western Australia</institution>, Perth, WA,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Lizio, Marina" sort="Lizio, Marina" uniqKey="Lizio M" first="Marina" last="Lizio">Marina Lizio</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sahin, Serkan" sort="Sahin, Serkan" uniqKey="Sahin S" first="Serkan" last="Sahin">Serkan Sahin</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Sengstag, Thierry" sort="Sengstag, Thierry" uniqKey="Sengstag T" first="Thierry" last="Sengstag">Thierry Sengstag</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Severin, Jessica" sort="Severin, Jessica" uniqKey="Severin J" first="Jessica" last="Severin">Jessica Severin</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Shimoji, Hisashi" sort="Shimoji, Hisashi" uniqKey="Shimoji H" first="Hisashi" last="Shimoji">Hisashi Shimoji</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a76"><institution>Preventive medicine and applied genomics unit, RIKEN Advanced Center for Computing and Communication</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Suzuki, Masanori" sort="Suzuki, Masanori" uniqKey="Suzuki M" first="Masanori" last="Suzuki">Masanori Suzuki</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Suzuki, Harukazu" sort="Suzuki, Harukazu" uniqKey="Suzuki H" first="Harukazu" last="Suzuki">Harukazu Suzuki</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kawai, Jun" sort="Kawai, Jun" uniqKey="Kawai J" first="Jun" last="Kawai">Jun Kawai</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a77"><institution>RIKEN Preventive Medicine and Diagnosis Innovation Program</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kondo, Naoto" sort="Kondo, Naoto" uniqKey="Kondo N" first="Naoto" last="Kondo">Naoto Kondo</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Itoh, Masayoshi" sort="Itoh, Masayoshi" uniqKey="Itoh M" first="Masayoshi" last="Itoh">Masayoshi Itoh</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a77"><institution>RIKEN Preventive Medicine and Diagnosis Innovation Program</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Daub, Carsten O" sort="Daub, Carsten O" uniqKey="Daub C" first="Carsten O." last="Daub">Carsten O. Daub</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a25"><institution>Department of Biosciences and Nutrition, Karolinska Institutet</institution>, Halsovagen 7-9, SE-141 83 Huddinge,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Kasukawa, Takeya" sort="Kasukawa, Takeya" uniqKey="Kasukawa T" first="Takeya" last="Kasukawa">Takeya Kasukawa</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kawaji, Hideya" sort="Kawaji, Hideya" uniqKey="Kawaji H" first="Hideya" last="Kawaji">Hideya Kawaji</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a76"><institution>Preventive medicine and applied genomics unit, RIKEN Advanced Center for Computing and Communication</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a77"><institution>RIKEN Preventive Medicine and Diagnosis Innovation Program</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Carninci, Piero" sort="Carninci, Piero" uniqKey="Carninci P" first="Piero" last="Carninci">Piero Carninci</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Forrest, Alistair R R" sort="Forrest, Alistair R R" uniqKey="Forrest A" first="Alistair R. R." last="Forrest">Alistair R. R. Forrest</name><affiliation><nlm:aff id="a1"><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a49"><institution>Harry Perkins Institute of Medical Research</institution>, Perth, WA 6009,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Hayashizaki, Yoshihide" sort="Hayashizaki, Yoshihide" uniqKey="Hayashizaki Y" first="Yoshihide" last="Hayashizaki">Yoshihide Hayashizaki</name><affiliation><nlm:aff id="a2"><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></nlm:aff></affiliation><affiliation><nlm:aff id="a77"><institution>RIKEN Preventive Medicine and Diagnosis Innovation Program</institution>, Wako, Saitama 351-0198,<country>Japan</country></nlm:aff></affiliation></author></analytic><series><title level="j">Scientific Data</title><idno type="eISSN">2052-4463</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands of samples, consisting of a variety of primary cells, tissues, cell lines, and time series samples during cell activation and development, were subjected to a uniform pipeline of CAGE data production. The analysis pipeline started by measuring RNA extracts to assess their quality, and continued to CAGE library production by using a robotic or a manual workflow, single molecule sequencing, and computational processing to generate frequencies of transcription initiation. Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells. Non-overlapping peaks over the CAGE profiles, approximately 200,000 and 150,000 peaks for the human and mouse genomes, were identified and annotated to provide precise location of known promoters as well as novel ones, and to quantify their activities.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Noguchi, S" uniqKey="Noguchi S">S. Noguchi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="data-paper"><pmc-dir>properties open_access</pmc-dir>
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contrib-id-type="orcid">http://orcid.org/0000-0002-0575-0308</contrib-id></contrib><contrib contrib-type="author"><name><surname>Carninci</surname><given-names>Piero</given-names></name><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Forrest</surname><given-names>Alistair R.R.</given-names></name><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a2">2</xref><xref ref-type="aff" rid="a49">49</xref></contrib><contrib contrib-type="author"><name><surname>Hayashizaki</surname><given-names>Yoshihide</given-names></name><xref ref-type="aff" rid="a2">2</xref><xref ref-type="aff" rid="a77">77</xref></contrib><aff id="a1"><label>1</label><institution>Division of Genomic Technologies, RIKEN Center for Life Science Technologies</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></aff><aff id="a2"><label>2</label><institution>RIKEN Omics Science Center</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></aff><aff id="a3"><label>3</label><institution>Department of Medicine, Karolinska Institutet</institution>, 141 86, Stockholm,<country>Sweden</country></aff><aff id="a4"><label>4</label><institution>Karolinska University Hospital, Center for Metabolism and Endocrinology</institution>, 141 86, Stockholm,<country>Sweden</country></aff><aff id="a5"><label>5</label><institution>Scottish Centre for Regenerative Medicine, University of Edinburgh</institution>, 5 Little France Drive, Edinburgh EH16 4UU,<country>UK</country></aff><aff id="a6"><label>6</label><institution>Department of Dermatology and Allergy, Charite University Medicine Berlin</institution>, Charitéplatz 1, 10117 Berlin,<country>German</country></aff><aff id="a7"><label>7</label><institution>The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh</institution>, Edinburgh, Midlothian EH25 9RG,<country>UK</country></aff><aff id="a8"><label>8</label><institution>Australian Infectious Diseases Research Centre, The University of Queensland</institution>, St Lucia, QLD 4072,<country>Australia</country></aff><aff id="a9"><label>9</label><institution>School of Chemistry and Molecular Biosciences, The University of Queensland</institution>, St Lucia, QLD 4072,<country>Australia</country></aff><aff id="a10"><label>10</label><institution>Bio-Rad Laboratories Pty Ltd</institution>, Hercules, California 94547,<country>USA</country></aff><aff id="a11"><label>11</label><institution>The University of Queensland Diamantina Institute, The University of Queensland</institution>, Woolloongabba, QLD 4102<country>Australia</country></aff><aff id="a12"><label>12</label><institution>IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64</institution>, 00143 Rome,<country>Italy</country></aff><aff id="a13"><label>13</label><institution>Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland</institution>, Brisbane, St Lucia, QLD 4072,<country>Australia</country></aff><aff id="a14"><label>14</label><institution>Division of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></aff><aff id="a15"><label>15</label><institution>Immunology of Infectious Diseases, Faculty of Health Sciences, South African Medical Research Council (SAMRC), University of Cape Town</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></aff><aff id="a16"><label>16</label><institution>International Centre for Genetic Engineering and Biotechnology, Cape Town Component</institution>, Anzio Road, Observatory 7925, Cape Town,<country>South Africa</country></aff><aff id="a17"><label>17</label><institution>Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences</institution>, Uppsalalaan 8, 3584 CT Utrecht,<country>The Netherlands</country></aff><aff id="a18"><label>18</label><institution>University Medical Centre Utrecht</institution>, Postbus 85500, 3508 GA Utrecht,<country>The Netherlands</country></aff><aff id="a19"><label>19</label><institution>Genomics, Cold Spring Harbor Laboratory</institution>, Cold Spring Harbor, New York 11797,<country>USA</country></aff><aff id="a20"><label>20</label><institution>Institute of Pharmaceutical Sciences, ETH Zurich</institution>, Vladimir-Prelog-Weg 3, HCI H 303, 8093 Zurich,<country>Switzerland</country></aff><aff id="a21"><label>21</label><institution>Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute National Center for Global Health and Medicine</institution>, Ichikawa, Chiba 272-8516,<country>Japan</country></aff><aff id="a22"><label>22</label><institution>Department of Otology and Laryngology, Harvard Medical School</institution>, Boston, Massachusetts 02114,<country>USA</country></aff><aff id="a23"><label>23</label><institution>Department of Internal Medicine III, University Hospital Regensburg</institution>, F.-J.-Strauss Allee 11, D-93053 Regensburg,<country>Germany</country></aff><aff id="a24"><label>24</label><institution>RCI Regensburg Centre for Interventional Immunology, University Hospital Regensburg</institution>, F.-J.-Strauss Allee 11, D-93053 Regensburg,<country>Germany</country></aff><aff id="a25"><label>25</label><institution>Department of Biosciences and Nutrition, Karolinska Institutet</institution>, Halsovagen 7-9, SE-141 83 Huddinge,<country>Sweden</country></aff><aff id="a26"><label>26</label><institution>RIKEN Center for Integrative Medical Sciences</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></aff><aff id="a27"><label>27</label><institution>Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology</institution>, Chuou-ku, Kobe 650-0047,<country>Japan</country></aff><aff id="a28"><label>28</label><institution>Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University</institution>, Bunkyo-ku, Tokyo 113-8510,<country>Japan</country></aff><aff id="a29"><label>29</label><institution>F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School</institution>, Boston, Massachusetts 02115,<country>USA</country></aff><aff id="a30"><label>30</label><institution>The University of Texas Health Science Center at Houston</institution>, Houston, TX 77251-1892,<country>USA</country></aff><aff id="a31"><label>31</label><institution>Cancer Biology Program, Mater Medical Research Institute</institution>, South Brisbane, Queensland 4101,<country>Australia</country></aff><aff id="a32"><label>32</label><institution>Berlin Institute for Medical Systems Biology, Max Delbrueck Center</institution>, Robert Roessle Str.10, 13125 Berlin,<country>Germany</country></aff><aff id="a33"><label>33</label><institution>Department of Medical Biochemistry, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></aff><aff id="a34"><label>34</label><institution>Experimental Immunology, Academic Medical Center, University of Amsterdam</institution>, Meibergdreef 9, 1105 AZ Amsterdam,<country>The Netherlands</country></aff><aff id="a35"><label>35</label><institution>Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia</institution>, Vancouver, British Columbia V5Z 4H4,<country>Canada</country></aff><aff id="a36"><label>36</label><institution>Neuroscience, SISSA</institution>, Via Bonomea 265, 34136 Trieste,<country>Italy</country></aff><aff id="a37"><label>37</label><institution>Department of Neuroscience and Brian Technologies, Italian Istitute of Technology</institution>, Via Morego 30, Genova,<country>Italy</country></aff><aff id="a38"><label>38</label><institution>Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University</institution>, Suita, Osaka 565-0871,<country>Japan</country></aff><aff id="a39"><label>39</label><institution>RIKEN Center for Life Science Technologies</institution>, Wako, Saitama 351-0198,<country>Japan</country></aff><aff id="a40"><label>40</label><institution>Melanoma Research Center, The Wistar Institute</institution>, Philadelphia, Pennsylvania 19104,<country>USA</country></aff><aff id="a41"><label>41</label><institution>German Center for Neurodegenerative Diseases (DZNE)-Tübingen</institution>, Otfried Müller Straße 23, 72076 Tübingen,<country>Germany</country></aff><aff id="a42"><label>42</label><institution>Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></aff><aff id="a43"><label>43</label><institution>International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></aff><aff id="a44"><label>44</label><institution>Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital</institution>, Brisbane, QLD 4102,<country>Australia</country></aff><aff id="a45"><label>45</label><institution>Department of Genetics and Molecular Medicine, King's College London</institution>, Guy’s St Thomas Street, London,<country>UK</country></aff><aff id="a46"><label>46</label><institution>Centre for Vascular Research, University of New South Wales</institution>, Sydney, New South Wales 2052,<country>Australia</country></aff><aff id="a47"><label>47</label><institution>Vascular Biology and Translational Research, School of Medical Sciences, University of New South Wales</institution>, Sydney, New South Wales 2052,<country>Australia</country></aff><aff id="a48"><label>48</label><institution>Division of Cellular Therapy and Division of Stem Cell Signaling, Institute of Medical Science, University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></aff><aff id="a49"><label>49</label><institution>Harry Perkins Institute of Medical Research</institution>, Perth, WA 6009,<country>Australia</country></aff><aff id="a50"><label>50</label><institution>Respiratory Medicine, University of Nottingham</institution>, Hucknall Road, Nottingham NG5 1PB,<country>UK</country></aff><aff id="a51"><label>51</label><institution>Dermatology, School of Medicine Kyungpook National University</institution>, Jung-gu, Daegu 41944,<country>Korea</country></aff><aff id="a52"><label>52</label><institution>Griffith University</institution>, Brisbane, Queensland 4111,<country>Australia</country></aff><aff id="a53"><label>53</label><institution>Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University</institution>, Hidaka, Saitama 350-1241,<country>Japan</country></aff><aff id="a54"><label>54</label><institution>Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8575,<country>Japan</country></aff><aff id="a55"><label>55</label><institution>Anatomy and Embryology, Leiden University Medical Center</institution>, Einthovenweg 20, P.O. Box 9600, 2300 RC Leiden,<country>The Netherlands</country></aff><aff id="a56"><label>56</label><institution>Division of Translational Research, Research Center for Genomic Medicine, Saitama Medical University</institution>, Hidaka, Saitama 350-1241,<country>Japan</country></aff><aff id="a57"><label>57</label><institution>Cell Engineering Division, RIKEN BioResource Center</institution>, Tsukuba, Ibaraki 305-0074,<country>Japan</country></aff><aff id="a58"><label>58</label><institution>Department of Clinical Molecular Genetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences</institution>, Hachioji, Tokyo 192-0392,<country>Japan</country></aff><aff id="a59"><label>59</label><institution>Department of Bioclinical Informatics, Tohoku Medical Megabank Organization, Tohoku University</institution>, Sendai, Miyagi 980-8573,<country>Japan</country></aff><aff id="a60"><label>60</label><institution>Department of Biochemistry, Ohu University School of Pharmaceutical Sciences</institution>, Koriyama, Fukushima 963-8611<country>Japan</country></aff><aff id="a61"><label>61</label><institution>Insitute for Protein Research, Osaka University</institution>, Suita, Osaka 565-0871,<country>Japan</country></aff><aff id="a62"><label>62</label><institution>Environmental Epigenetics Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST)</institution>, Thuwal 23955-6900,<country>Kingdom of Saudi Arabia</country></aff><aff id="a63"><label>63</label><institution>University of Delaware</institution>, Newark, DE 19716<country>USA</country></aff><aff id="a64"><label>64</label><institution>Hjelt Institute, Department of Forensic Medicine, University of Helsinki</institution>, Kytosuontie 11, 003000 Helsinki,<country>Finland</country></aff><aff id="a65"><label>65</label><institution>Laboratorio Nazionale CIB, Padriciano</institution>, 99 34149, Trieste,<country>Italy</country></aff><aff id="a66"><label>66</label><institution>Department of Orthopedic, Trauma and Reconstructive Surgery, Charite Universitatsmedizin Berlin</institution>, Charitéplatz 1, 10117 Berlin,<country>German</country></aff><aff id="a67"><label>67</label><institution>International Research Center for Medical Sciences (IRCMS), Kumamoto University</institution>, Chuo-ku, Kumamoto 860-0811,<country>Japan</country></aff><aff id="a68"><label>68</label><institution>Department of Clinical Study, Center for Advanced Medical Innovation, Kyushu University</institution>, Higashi-Ku, Fukuoka 812-8582,<country>Japan</country></aff><aff id="a69"><label>69</label><institution>Graduate School of Pharmaceutical Sciences, Nagoya University</institution>, Nagoya, Aichi 464-8601,<country>Japan</country></aff><aff id="a70"><label>70</label><institution>Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie (LNCIB)</institution>, Padriciano 99, 34149 Trieste,<country>Italy</country></aff><aff id="a71"><label>71</label><institution>QIMR Berghofer Medical Research Institute</institution>, Brisbane, QLD 4006,<country>Australia</country></aff><aff id="a72"><label>72</label><institution>Centre for Stem Cell Systems, Department of Anatomy and Neuroscience, MDHS, University of Melbourne</institution>, Melbourne, VIC 3010,<country>Australia</country></aff><aff id="a73"><label>73</label><institution>Department of Biochemistry, Nihon University School of Dentistry</institution>, Chiyoda-ku, Tokyo 101-8310,<country>Japan</country></aff><aff id="a74"><label>74</label><institution>Center for Clinical and Translational Reseach, Kyushu University Hospital</institution>, Higashi-Ku, Fukuoka 812-8582,<country>Japan</country></aff><aff id="a75"><label>75</label><institution>Telethon Kids Institute, the University of Western Australia</institution>, Perth, WA,<country>Australia</country></aff><aff id="a76"><label>76</label><institution>Preventive medicine and applied genomics unit, RIKEN Advanced Center for Computing and Communication</institution>, Yokohama, Kanagawa 230-0045,<country>Japan</country></aff><aff id="a77"><label>77</label><institution>RIKEN Preventive Medicine and Diagnosis Innovation Program</institution>, Wako, Saitama 351-0198,<country>Japan</country></aff></contrib-group><author-notes><corresp id="c1"><label>a</label>H.K. (email: <email>kawaji@gsc.riken.jp</email>).
</corresp><fn id="con"><label></label><p>Samples were provided by P. Arner, R. Axton, M. Babina, J. Baillie, T. Barnett, A. Beckhouse, A. Blumenthal, B. Bodega, A. Bonetti, J. Briggs, F. Brombacher, A. Carlisle, H. Clevers, C. Davis, M. Detmar, T. Dohi, A. Edge, M. Edinger, A. Ehrlund, K. Ekwall, M. Endoh, H. Enomoto, A. Eslami, M. Fagiolini, L. Fairbairn, M. Farach-Carson, G. Faulkner, C. Ferrai, M. Fisher, L. Forrester, R. Fujita, J. Furusawa, T. Geijtenbeek, T. Gingeras, D. Goldowitz, S. Guhl, R. Guler, S. Gustincich, T. Ha, M. Hamaguchi, M. Hara, Y. Hasegawa, M. Herlyn, P. Heutink, K. Hitchens, D. Hume, T. Ikawa, Y. Ishizu, C. Kai, H. Kawamoto, Y. Kawamura, J. Kempfle, T. Kenna, J. Kere, L. Khachigian, T. Kitamura, S. Klein, S. Klinken, A. Knox, S. Kojima, H. Koseki, S. Koyasu, W. Lee, A. Lennartsson, A. Mackay-sim, N. Mejhert, Y. Mizuno, H. Morikawa, M. Morimoto, K. Moro, K. Morris, H. Motohashi, C. Mummery, Y. Nakachi, F. Nakahara, T. Nakamura, Y. Nakamura, T. Nozaki, S. Ogishima, N. Ohkura, H. Ohno, M. Ohshima, M. Okada-Hatakeyama, Y. Okazaki, V. Orlando, D. Ovchinnikov, R. Passier, M. Patrikakis, A. Pombo, S. Pradhan-Bhatt, X. Qin, M. Rehli, P. Rizzu, S. Roy, A. Sajantila, S. Sakaguchi, H. Sato, H. Satoh, S. Savvi, A. Saxena, C. Schmidl, C. Schneider, G. Schulze-Tanzil, A. Schwegmann, G. Sheng, J. Shin, D. Sugiyama, T. Sugiyama, K. Summers, N. Takahashi, J. Takai, H. Tanaka, H. Tatsukawa, A. Tomoiu, H. Toyoda, M. van de Wetering, L. van den Berg, R. Verardo, D. Vijayan, C. Wells, L. Winteringham, E. Wolvetang, Y. Yamaguchi, M. Yamamoto, C. Yanagi-Mizuochi, M. Yoneda, Y. Yonekura, P. Zhang, S. Zucchelli; CAGE data was produced by T. Arakawa, S. Fukuda, M. Furuno, A. Hasegawa, F. Hori, S. Ishikawa-Kato, K. Kaida, A. Kaiho, M. Kanamori-Katayama, T. Kawashima, M. Kojima, A. Kubosaki, R. Manabe, M. Murata, S. Nagao-Sato, K. Nakazato, N. Ninomiya, H. Nishiyori-Sueki, S. Noma, E. Saijyo, A. Saka, M. Sakai, C. Simon, N. Suzuki, M. Tagami, S. Watanabe, S. Yoshida; Data quality was assessed by S. Noguchi, I. Abugessaisa, E. Arner, J. Harshbarger, A. Kondo, T. Lassmann, M. Lizio, S. Sahin, T. Sengstag, J. Severin, H. Shimoji, H. Kawaji, A. Forrest; Data description is achieved by S. Noguchi, T. Kasukawa, H. Kawaji; Project is organized by M. Suzuki, H. Suzuki, J. Kawai, N. Kondo, M. Itoh, C. Daub, T. Kasukawa, H. Kawaji, P. Carninci, A. Forrest, Y. Hayashizaki.</p></fn></author-notes><pub-date pub-type="epub"><day>29</day><month>08</month><year>2017</year></pub-date><pub-date pub-type="collection"><year>2017</year></pub-date><volume>4</volume><elocation-id>170112</elocation-id><history><date date-type="received"><day>06</day><month>12</month><year>2016</year></date><date date-type="accepted"><day>25</day><month>04</month><year>2017</year></date></history><permissions><copyright-statement>Copyright © 2017, The Author(s)</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>The Author(s)</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><pmc-comment>author-paid</pmc-comment>
<license-p><bold>Open Access</bold> This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link> The Creative Commons Public Domain Dedication waiver <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link> applies to the metadata files made available in this article.
</license-p></license></permissions><related-article ext-link-type="doi" related-article-type="companion" id="d32e21" xlink:href="10.1038/sdata.2017.113"></related-article><related-article ext-link-type="doi" related-article-type="data-paper-referrer" id="d32e22" xlink:href="10.1038/nature13182"></related-article><related-article ext-link-type="doi" related-article-type="data-paper-referrer" id="d32e2139" xlink:href="10.1126/science.1259418"></related-article><abstract><p>In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands of samples, consisting of a variety of primary cells, tissues, cell lines, and time series samples during cell activation and development, were subjected to a uniform pipeline of CAGE data production. The analysis pipeline started by measuring RNA extracts to assess their quality, and continued to CAGE library production by using a robotic or a manual workflow, single molecule sequencing, and computational processing to generate frequencies of transcription initiation. Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells. Non-overlapping peaks over the CAGE profiles, approximately 200,000 and 150,000 peaks for the human and mouse genomes, were identified and annotated to provide precise location of known promoters as well as novel ones, and to quantify their activities.</p></abstract><kwd-group kwd-group-type="npg.subject"><title>Subject terms</title><kwd>Systems biology</kwd><kwd>Cell biology</kwd><kwd>Computational biology and bioinformatics</kwd><kwd>Developmental biology</kwd><kwd>Molecular biology</kwd></kwd-group></article-meta></front><body><sec disp-level="1"><title>Background & Summary</title><p>Since the completion of the human genome sequencing, role of individual bases has been a central question. An international collaborative effort, FANTOM (Functional ANnoTation Of Mammalian Genome)<sup><xref ref-type="bibr" rid="b1">1</xref></sup>, delineated a complex landscape of transcribed RNAs (transcriptome) and their regulations. The initial key technology driving the project was to make full-length cDNA clones, representing complete primary structure of transcribed RNA molecules. Sequencing of the full-length cDNA clones uncovered unexpected number of long non-coding RNAs as well as protein coding genes<sup><xref ref-type="bibr" rid="b2">2–6</xref></sup>. The CAGE (Cap Analysis Gene Expression)<sup><xref ref-type="bibr" rid="b7">7</xref>,<xref ref-type="bibr" rid="b8">8</xref></sup> protocol, combination with high-throughput sequencing, was developed to monitor frequencies of transcription initiation by determining 5′-end of capped RNAs. The technology was devised to uncover complexity of the transcriptome<sup><xref ref-type="bibr" rid="b4">4–6</xref></sup> and elucidate transcriptional regulatory networks by focusing on promoter elements<sup><xref ref-type="bibr" rid="b9">9–12</xref></sup>. By taking advantage of single molecule sequencer, HeliScopeCAGE was recently developed to provide more sensitive and accurate monitoring of transcription initiation activities<sup><xref ref-type="bibr" rid="b7">7</xref>,<xref ref-type="bibr" rid="b8">8</xref></sup>.</p><p>In the fifth round of the FANTOM projects, FANTOM5, the challenge was to capture the transcriptome of many varieties of cell states as possible, to understand the implication of each genomic bases in different contexts. In the first phase of the FANTOM5 project, we targeted cells in steady state, called ‘snapshot’ samples<sup><xref ref-type="bibr" rid="b13">13</xref></sup>. Our central focus was on human primary cells, while cell lines, tissues and mouse samples were chosen to cover cells inaccessible as isolated human primary samples. The resulting data provided an atlas of promoter and enhancer activities in wide range of cell states<sup><xref ref-type="bibr" rid="b14">14</xref></sup>, which is a baseline of understanding complex transcriptional regulation. In the second phase, we focused on transitions of cell states by monitoring ‘time course’ samples, such as activations, differentiations, and developments at sequential time points<sup><xref ref-type="bibr" rid="b15">15</xref></sup>. The monitored activities of promoters and enhancers demonstrated that enhancer activities is the earliest event during dynamic changes of transcriptome. These data sets are being utilized in many other studies inside and outside of the FANTOM5 consortium.</p><p>The data production scheme was implemented based on the FANTOM5 collaboration. Sample collection was performed at individual institutes, since specific types of samples require dedicated systems with special expertise or settings, as well as through purchase from commercial sources. RNA quality was firstly examined at the place where the samples were obtained (the first RNA quality check). The CAGE assay pipeline established in RIKEN GeNAS (Genome Network Analysis Support Facility) employed two workflows of HeliScopeCAGE, a manual workflow for samples with small amount of total RNAs<sup><xref ref-type="bibr" rid="b8">8</xref></sup> and a robotic workflow for samples with standard requirements<sup><xref ref-type="bibr" rid="b7">7</xref></sup>. The assay pipeline started with checking RNA quality (the second RNA quality check), which provides a uniform quality assessment of the profiled RNA extracts. The resulting CAGE libraries were sequenced by HeliScope in RIKEN and also in Helicos Biosciences, and the obtained data were processed by the MOIRAI system<sup><xref ref-type="bibr" rid="b16">16</xref></sup>. Quality of the resulting CAGE profiles was checked with several statistics as well as manual inspection by using the ZENBU browser<sup><xref ref-type="bibr" rid="b17">17</xref></sup>. Finally CAGE profiles were shared among the consortium for further analysis.</p><p>In the course of the two phases focused on ‘snapshot’ and ‘time course’ samples, we profiled 1,816 human and 1,016 mouse samples in total, and obtained approximately four millions of single-molecule reads successfully aligned to the genome per sample on average. Based on frequencies of the observed 5′-ends of individual capped RNA molecules at a single base-pair resolution, we identified 201,802 and 158,966 peaks for human and mouse respectively, where promoters are defined as the sequence immediately upstream of the peaks and frequencies of observed CAGE reads reflect activities of the promoters. All data generated during the course of the project were deposited to a public repository (DDBJ Read Archive, DRA) and/or provided at the FANTOM5 web resource (<ext-link ext-link-type="uri" xlink:href="http://fantom.gsc.riken.jp/5/">http://fantom.gsc.riken.jp/5/</ext-link>)<sup><xref ref-type="bibr" rid="b18">18</xref></sup>. Here we describe the data with the processing details and quality metrics.</p></sec><sec disp-level="1"><title>Methods</title><sec disp-level="2"><title>Sample collection</title><p>Sample collection was performed as described previously<sup><xref ref-type="bibr" rid="b13">13</xref>,<xref ref-type="bibr" rid="b15">15</xref></sup>. Briefly, primary cells were purchased as purified RNAs or frozen cells, or obtained as described previously<sup><xref ref-type="bibr" rid="b19">19–24</xref></sup> through collaboration in the consortium. Purchased cells were cultured according to the manufacturer’s instructions and miRNeasy kit (QIAGEN) was used for RNA extraction. Human post mortem tissue RNAs were purchased or obtained through the Dutch Brain bank. Tissues collected through the consortium were snap-frozen in liquid nitrogen, transferred into Lysing Matrix D tubes (MP Biomedicals, Santa Ana, CA) containing chilled Trizol (Gibco), homogenized by FastPrep Homogenizer (Thermo Savant), and centrifuged. miRNeasy kit (QIAGEN) was used for RNA extraction from cultured cell lines as well as frozen cell line stocks.</p><p>For the purchased samples, lot or catalogue numbers were recorded where available. Of the collected RNAs, those with more than 1 μg, were measured by Agilent BioAnalyzer (Agilent Technologies, Santa Clara, CA) and Nanodrop spectrophotometer (Thermo Fisher Scientific, Wilmington, DE) to check RIN (RNA integrity) score and the absorbance ratio of A260/A230 and A260/A280. The rest of the samples were directly subjected to the CAGE library production to avoid wasting material. All 2,832 profiled samples are summarized in <xref ref-type="table" rid="t1">Table 1</xref>.</p></sec><sec disp-level="2"><title>Single molecule CAGE and data processing</title><p>HeliScopeCAGE libraries were prepared, sequenced, and processed as described previously<sup><xref ref-type="bibr" rid="b13">13</xref>,<xref ref-type="bibr" rid="b15">15</xref></sup>. Most of the RNAs were subjected to the automated HeliScopeCAGE protocol<sup><xref ref-type="bibr" rid="b7">7</xref></sup>, except for RNAs with less than 1 μg that were subjected to the manual protocol optimized for low quantity RNAs<sup><xref ref-type="bibr" rid="b8">8</xref></sup>. The resulting libraries were measured by OliGreen fluorescence assay kit (Life Technologies), and sequenced by following the manufacturer’s instructions (LB-016_01, LB-017_01, and LB-001_04 (ref. <xref ref-type="bibr" rid="b13">13</xref>). RNAs extracted from mouse whole body embryo E17.5 (called internal control) were systematically subjected to this workflow, with one per a sequencing run.</p><p>The produced data were processed as previously described<sup><xref ref-type="bibr" rid="b13">13</xref>,<xref ref-type="bibr" rid="b15">15</xref></sup>. Briefly, reads corresponding to ribosomal RNA were removed by using the program rRNAdust (<ext-link ext-link-type="uri" xlink:href="http://fantom.gsc.riken.jp/5/suppl/rRNAdust/">http://fantom.gsc.riken.jp/5/suppl/rRNAdust/</ext-link>), remaining reads were aligned to the reference genome of human and mouse (hg19 or mm9) by using Delve<sup><xref ref-type="bibr" rid="b25">25</xref></sup>, and alignments with a quality of less than 20 (<99% chance of true) or a sequence identity of less than 85% were discarded. Frequencies of the CAGE read 5′ ends were counted to give a unit of CAGE tag start site (CTSS), a single base-pair on the reference genome. The entire flow of the data is illustrated in <xref ref-type="fig" rid="f1">Fig. 1</xref>, and the number of CAGE profiles (equivalent to CTSS files) is summarized in <xref ref-type="table" rid="t2">Table 2</xref>.</p></sec><sec disp-level="2"><title>Identification of peaks and their annotations</title><p>Non-overlapping peaks based on the all CAGE profiles were identified by using DPI (decomposition-based peak identification, <ext-link ext-link-type="uri" xlink:href="https://github.com/hkawaji/dpi1/">https://github.com/hkawaji/dpi1/</ext-link>) method and annotated as previously described<sup><xref ref-type="bibr" rid="b13">13</xref>,<xref ref-type="bibr" rid="b15">15</xref></sup>. A ‘robust’ threshold, for which a peak must include a CTSS with more than 10 read counts and 1 TPM (tags per million) at least one sample, was employed to define a stringent subset of the CAGE peaks. The robust peaks were associated with known transcripts, such as RefSeq<sup><xref ref-type="bibr" rid="b26">26</xref></sup>, UCSC known gene<sup><xref ref-type="bibr" rid="b27">27</xref></sup>, GENCODE<sup><xref ref-type="bibr" rid="b28">28</xref></sup>, Ensembl<sup><xref ref-type="bibr" rid="b29">29</xref></sup>, and mRNAs (full-length cDNA clones), based on their 5′-end proximity to the peaks. Official gene symbols, Entrez Gene IDs, and protein (UniProt) IDs associated with the transcripts were retrieved and assigned as part of annotation. In addition to these associations, human readable names and descriptions were assigned to each of the CAGE peaks. Peaks were given a name in the form pN@GENE, where GENE indicates gene symbol or transcript name and N indicates the rank in the ranked list of promoter activities for that gene. For example, p1@SPI1 represent the peak with the highest number of observation (that is, read counts) in all of the FANTOM5 CAGE profiles, among the peaks associated with SPI1 gene.</p><p>Peak identification with the same method and the same threshold was performed two times; the first was for ‘snapshot’ samples (phase 1), and the second was for the entire samples from both the ‘snapshot’ and ‘time course’ studies (phase 2). We integrated these two peak sets into a hybrid set consisting of all the phase 1 peaks over the robust threshold and a subset of phase 2 peaks that did not overlap with the phase 1 peaks. Annotation of phase1 peaks was used in the hybrid set, called phase 1+2 peaks, which provide a consistent reference in the definition of promoters.</p></sec><sec disp-level="2"><title>Quantification of promoter activities</title><p>All the obtained CAGE profiles were subjected to the peak identification, even if they have some issues in quality, since all of them still represent independent observations of RNA 5′-ends. However promoter activities (that is, expression levels of CAGE peaks) were quantified only in the samples satisfying the following criteria: RIN score greater than 6, more than 500,000 successfully aligned reads to the genome, and more than 50% of the successful alignments are close to 5′-end of RefSeq gene model, for expression analysis requiring reliable quantification. After discarding a few CAGE profiles of low quality, read counts for individual CTSSs belonging to the same peak were summed up, normalization (or scaling) factors were calculated with RLE (Relative Log Expression)<sup><xref ref-type="bibr" rid="b30">30</xref></sup> method by edgeR<sup><xref ref-type="bibr" rid="b31">31</xref></sup>, and tags per million (that is, counts per million) was computed as expression levels.</p><p>The RLE normalization was first performed within the phase 1 samples. The naïve application of this to the entire data sets, consisting of phase 1 and phase 2 samples, might cause inconsistencies in expression levels between the two normalizations. To avoid this, we took the geometric mean of CAGE peak read counts across the phase 1 samples and used it as the reference expression for a normalization factor calculation in the same manner as RLE method. This enabled us to keep the expression levels of phase 1 as they were, and to adjust the expression levels of the phase 2 samples to be comparable<sup><xref ref-type="bibr" rid="b15">15</xref></sup>.</p></sec><sec disp-level="2"><title>Code availability</title><p>All software used in this study are publicly available. rRNAdust, for removing ribosomal RNA, is available at <ext-link ext-link-type="uri" xlink:href="http://fantom.gsc.riken.jp/5/suppl/rRNAdust/">http://fantom.gsc.riken.jp/5/suppl/rRNAdust/</ext-link>. Mapping software Delve is available at <ext-link ext-link-type="uri" xlink:href="http://fantom.gsc.riken.jp/5/suppl/delve/">http://fantom.gsc.riken.jp/5/suppl/delve/</ext-link>. The program to perform DPI, decomposition-based peak identification, method is available at <ext-link ext-link-type="uri" xlink:href="https://github.com/hkawaji/dpi1/">https://github.com/hkawaji/dpi1/</ext-link>.</p></sec></sec><sec disp-level="1"><title>Data Records</title><sec disp-level="2"><title>Data record 1: Metadata</title><p>Two types of metadata are available at figshare and LSDB Archive (Data Citation 1, 10). One is for the samples, including their origins and extracted RNA. The other is for the CAGE assay, including the result of RNA quality check, library production, and post-processing of the CAGE tag sequences. Both of them are described in SDRF (Sample and Data Relationship Format)<sup><xref ref-type="bibr" rid="b32">32</xref></sup>. Sample metadata for human and mouse are ‘HumanSamples2.0.sdrf.xlsx’ and ‘MouseSamples2.0.sdrf.xlsx’, respectively. The metadata for the CAGE assay are available as ‘*sdrf.txt’.</p></sec><sec disp-level="2"><title>Data record 2: CAGE profiles</title><p>All of the CAGE sequences, their alignment to the genomes, and CTSS frequencies are available at DDBJ DRA (DDBJ Sequence Read Archive) (Data Citations 2–9). The accession number of each file is summarized in ‘DRA*.txt’ at figshare (Data Citation 1).</p></sec><sec disp-level="2"><title>Data record 3: CAGE peaks</title><p>Genomic coordinates, annotations and expressions of the CAGE peaks are available as ‘*phase1and2combined_coord.bed.gz’, ‘*phase1and2combined_ann.txt.gz’, and ‘*phase1and2combined_tpm.osc.txt.gz’ respectively at figshare (Data Citation 1). Genomic coordinates are formatted in BED format, and the others are formatted in OSCtable (Order Switchable Column table). The detail of the OSCtable format is available at <ext-link ext-link-type="uri" xlink:href="https://sourceforge.net/projects/osctf/">https://sourceforge.net/projects/osctf/</ext-link>.</p></sec></sec><sec disp-level="1"><title>Technical Validation</title><sec disp-level="2"><title>RNA quality</title><p>Measured RNA qualities at the second check (that is, immediately before the CAGE library production) are shown in <xref ref-type="fig" rid="f2">Fig. 2a–c</xref>. RNA Integrity Number (RIN) score, measured using an Agilent Bioanalyzer, was 8.96 on average (standard deviation 1.19), absorbance ratio of 260/230 nm (A260/A230) and 260/280 nm (A260/A280) were on average 2.01 (standard deviation 0.53) and 2.13 (standard deviation 0.14) respectively. These figures indicate that the majority of the RNAs were processed in good quality.</p></sec><sec disp-level="2"><title>Mapped reads</title><p>The number of CAGE reads successfully aligned with the genome and the ratio of CAGE reads hitting conventional promoters are shown in <xref ref-type="fig" rid="f2">Fig. 2d,e</xref>. The average number of mapped reads is 4,208,291 per CAGE profile. Of the 2,522 profiles, 98.3% (2,478) consists of at least 500,000 successfully aligned reads, which was a criterion of profiles used for expression analysis<sup><xref ref-type="bibr" rid="b13">13</xref></sup>. The average ratio of promoter-hitting reads is 76.5, and 98.6% of the all profiles (2,437/2,472) have more than 50% promoter-hitting rate, which was another criterion of profiles used for expression analysis<sup><xref ref-type="bibr" rid="b13">13</xref></sup>.</p></sec><sec disp-level="2"><title>Sample identity</title><p>Hierarchical clustering of the 126 mouse primary cells<sup><xref ref-type="bibr" rid="b13">13</xref></sup> within the phase 1 was shown in <xref ref-type="fig" rid="f3">Fig. 3</xref>, and the same clustering of the 571 human primary cells<sup><xref ref-type="bibr" rid="b13">13</xref></sup> was in <xref ref-type="supplementary-material" rid="S1">Supplementary Fig. 1</xref>. The average linkage method was applied to log-scale expression (TPM) profiles at promoter-level, and sample identities were assessed by expression of marker genes and also by manual inspection of the hierarchical clustering. The figures show that majority of biological replicates belonged to the same branch of the tree, that is, the same cluster, except for samples with a low number of mapped read counts.</p></sec></sec><sec disp-level="1"><title>Usage Notes</title><p>As well as providing access to individual data files, we also set up a series of interfaces as described in the FANTOM web resource<sup><xref ref-type="bibr" rid="b18">18</xref>,<xref ref-type="bibr" rid="b33">33</xref></sup>. TET (Table Extraction Tool) provides an interface to obtain a subset of data by specifying the desired columns and rows. The BioMart interface<sup><xref ref-type="bibr" rid="b34">34</xref></sup>, and FANTOM5 SSTAR (Semantic catalog of Samples, Transcription initiation And Regulators) provides the metadata of the profiled samples<sup><xref ref-type="bibr" rid="b35">35</xref></sup>. The CAGE profile on the genomic axis is visible in ZENBU<sup><xref ref-type="bibr" rid="b17">17</xref></sup> with its interactive interface and also in the UCSC genome browser<sup><xref ref-type="bibr" rid="b36">36</xref></sup> via track data hub<sup><xref ref-type="bibr" rid="b37">37</xref></sup>.</p></sec><sec disp-level="1"><title>Additional Information</title><p><bold>How to cite this article:</bold> Noguchi, S. <italic>et al.</italic> FANTOM5 CAGE profiles of human and mouse samples. <italic>Sci. Data</italic> 4:170112 doi: 10.1038/sdata.2017.112 (2017).</p><p><bold>Publisher’s note:</bold> Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></sec><sec sec-type="supplementary-material" id="S1"><title>Supplementary Material</title><supplementary-material id="d32e3034" content-type="local-data"><media xlink:href="sdata2017112-isa1.zip"></media></supplementary-material><supplementary-material id="d32e3035" content-type="local-data"><caption><title>Supplementary Fig. 1</title></caption><media xlink:href="sdata2017112-s2.pdf"></media></supplementary-material></sec></body><back><ref-list content-type="data-citations"><title>Data Citations</title><ref id="d1"><mixed-citation publication-type="data"><source>figshare</source><name><surname>Noguchi</surname><given-names>S.</given-names></name><year>2017</year><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.c.3728767">https://doi.org/10.6084/m9.figshare.c.3728767</ext-link></mixed-citation></ref><ref id="d2"><mixed-citation publication-type="data"><source>DDBJ Sequence Read Archive</source><year>2013</year><ext-link ext-link-type="uri" xlink:href="https://trace.ddbj.nig.ac.jp/DRASearch/submission?acc=DRA000991">DRA000991</ext-link></mixed-citation></ref><ref id="d3"><mixed-citation publication-type="data"><source>DDBJ Sequence Read Archive</source><year>2013</year><ext-link ext-link-type="uri" xlink:href="https://trace.ddbj.nig.ac.jp/DRASearch/submission?acc=DRA001026">DRA001026</ext-link></mixed-citation></ref><ref id="d4"><mixed-citation publication-type="data"><source>DDBJ Sequence Read Archive</source><year>2013</year><ext-link ext-link-type="uri" xlink:href="https://trace.ddbj.nig.ac.jp/DRASearch/submission?acc=DRA001027">DRA001027</ext-link></mixed-citation></ref><ref id="d5"><mixed-citation publication-type="data"><source>DDBJ Sequence Read Archive</source><year>2013</year><ext-link ext-link-type="uri" xlink:href="https://trace.ddbj.nig.ac.jp/DRASearch/submission?acc=DRA001028">DRA001028</ext-link></mixed-citation></ref><ref id="d6"><mixed-citation publication-type="data"><source>DDBJ Sequence Read Archive</source><year>2014</year><ext-link ext-link-type="uri" xlink:href="https://trace.ddbj.nig.ac.jp/DRASearch/submission?acc=DRA002216">DRA002216</ext-link></mixed-citation></ref><ref id="d7"><mixed-citation publication-type="data"><source>DDBJ Sequence Read Archive</source><year>2014</year><ext-link ext-link-type="uri" xlink:href="https://trace.ddbj.nig.ac.jp/DRASearch/submission?acc=DRA002711">DRA002711</ext-link></mixed-citation></ref><ref id="d8"><mixed-citation publication-type="data"><source>DDBJ Sequence Read Archive</source><year>2014</year><ext-link ext-link-type="uri" xlink:href="https://trace.ddbj.nig.ac.jp/DRASearch/submission?acc=DRA002747">DRA002747</ext-link></mixed-citation></ref><ref id="d9"><mixed-citation publication-type="data"><source>DDBJ Sequence Read Archive</source><year>2014</year><ext-link ext-link-type="uri" xlink:href="https://trace.ddbj.nig.ac.jp/DRASearch/submission?acc=DRA002748">DRA002748</ext-link></mixed-citation></ref><ref id="d10"><mixed-citation publication-type="data"><source>LSDB Archive</source><year>2016</year><ext-link ext-link-type="uri" xlink:href="http://doi.org/10.18908/lsdba.nbdc01389-000.V002">http://doi.org/10.18908/lsdba.nbdc01389-000.V002</ext-link></mixed-citation></ref></ref-list><ack><p>FANTOM5 was made possible by a Research Grant for RIKEN Omics Science Center from MEXT to Y.H. and a grant of the Innovative Cell Biology by Innovative Technology (Cell Innovation Program) from the MEXT, Japan to Y.H. 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Sky blue and beige color indicate locations storing the data, the FANTOM5 data archive (Data Citation 1, Data Citations 10) and in DDBJ Sequence Read Archive (Data Citations 2–9) respectively.</p></caption><graphic xlink:href="sdata2017112-f1"></graphic></fig><fig id="f2"><label>Figure 2</label><caption><title>RNA and mapping quality control.</title><p>Distribution of RIN score (<bold>a</bold>), A260/A230 (<bold>b</bold>), A260/A280 (<bold>c</bold>), mapped reads (<bold>d</bold>), and promoter rate (<bold>e</bold>) for samples used for FANTOM5 expression analysis.</p></caption><graphic xlink:href="sdata2017112-f2"></graphic></fig><fig id="f3"><label>Figure 3</label><caption><title>Hierarchical clustering of primary cells.</title><p>Hierarchical clustering of primary cell samples of mouse based on logarithm of expression (TPM). Color shows anatomical categories of samples.</p></caption><graphic xlink:href="sdata2017112-f3"></graphic></fig><table-wrap position="float" id="t1"><label>Table 1</label><caption><title>Summary of FANTOM5 phase 1 and phase 2 samples.</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><bold>Sample</bold></th><th colspan="2" align="center" valign="top" charoff="50"><bold>Phase 1</bold><hr></hr></th><th colspan="2" align="center" valign="top" charoff="50"><bold>Phase 2</bold><hr></hr></th><th align="center" valign="top" charoff="50"><bold>Total</bold></th></tr><tr><th align="left" valign="top" charoff="50"> </th><th align="center" valign="top" charoff="50"><bold>Human</bold></th><th align="center" valign="top" charoff="50"><bold>Mouse</bold></th><th align="center" valign="top" charoff="50"><bold>Human</bold></th><th align="center" valign="top" charoff="50"><bold>Mouse</bold></th><th align="center" valign="top" charoff="50"> </th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">Cell lines</td><td align="center" valign="top" charoff="50">259</td><td align="center" valign="top" charoff="50">1</td><td align="center" valign="top" charoff="50">9</td><td align="center" valign="top" charoff="50">0</td><td align="center" valign="top" charoff="50">269</td></tr><tr><td align="left" valign="top" charoff="50">Fractionations</td><td align="center" valign="top" charoff="50">12</td><td align="center" valign="top" charoff="50">0</td><td align="center" valign="top" charoff="50">9</td><td align="center" valign="top" charoff="50">0</td><td align="center" valign="top" charoff="50">21</td></tr><tr><td align="left" valign="top" charoff="50">Primary cells</td><td align="center" valign="top" charoff="50">537</td><td align="center" valign="top" charoff="50">109</td><td align="center" valign="top" charoff="50">24</td><td align="center" valign="top" charoff="50">31</td><td align="center" valign="top" charoff="50">701</td></tr><tr><td align="left" valign="top" charoff="50">Timecourse samples</td><td align="center" valign="top" charoff="50">35</td><td align="center" valign="top" charoff="50">19</td><td align="center" valign="top" charoff="50">748</td><td align="center" valign="top" charoff="50">572</td><td align="center" valign="top" charoff="50">1,374</td></tr><tr><td align="left" valign="top" charoff="50">Tissues</td><td align="center" valign="top" charoff="50">150</td><td align="center" valign="top" charoff="50">237</td><td align="center" valign="top" charoff="50">33</td><td align="center" valign="top" charoff="50">45</td><td align="center" valign="top" charoff="50">465</td></tr><tr><td align="left" valign="top" charoff="50">Quality control samples</td><td align="center" valign="top" charoff="50">0</td><td align="center" valign="top" charoff="50">1</td><td align="center" valign="top" charoff="50">0</td><td align="center" valign="top" charoff="50">1</td><td align="center" valign="top" charoff="50">2</td></tr><tr><td align="left" valign="top" charoff="50">Total</td><td align="center" valign="top" charoff="50">993</td><td align="center" valign="top" charoff="50">367</td><td align="center" valign="top" charoff="50">823</td><td align="center" valign="top" charoff="50">649</td><td align="center" valign="top" charoff="50">2,832</td></tr></tbody></table></table-wrap><table-wrap position="float" id="t2"><label>Table 2</label><caption><title>Sequence files (CTSS files).</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><bold>Sample</bold></th><th colspan="2" align="center" valign="top" charoff="50"><bold>Phase 1</bold><hr></hr></th><th colspan="2" align="center" valign="top" charoff="50"><bold>Phase 2</bold><hr></hr></th><th align="center" valign="top" charoff="50"><bold>Total</bold></th></tr><tr><th align="left" valign="top" charoff="50"> </th><th align="center" valign="top" charoff="50"><bold>Human</bold></th><th align="center" valign="top" charoff="50"><bold>Mouse</bold></th><th align="center" valign="top" charoff="50"><bold>Human</bold></th><th align="center" valign="top" charoff="50"><bold>Mouse</bold></th><th align="center" valign="top" charoff="50"> </th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">Cell lines</td><td align="center" valign="top" charoff="50">261</td><td align="center" valign="top" charoff="50">1</td><td align="center" valign="top" charoff="50">10</td><td align="center" valign="top" charoff="50">0</td><td align="center" valign="top" charoff="50">272</td></tr><tr><td align="left" valign="top" charoff="50">Fractionations</td><td align="center" valign="top" charoff="50">12</td><td align="center" valign="top" charoff="50">0</td><td align="center" valign="top" charoff="50">9</td><td align="center" valign="top" charoff="50">0</td><td align="center" valign="top" charoff="50">21</td></tr><tr><td align="left" valign="top" charoff="50">Primary cells</td><td align="center" valign="top" charoff="50">538</td><td align="center" valign="top" charoff="50">110</td><td align="center" valign="top" charoff="50">26</td><td align="center" valign="top" charoff="50">50</td><td align="center" valign="top" charoff="50">724</td></tr><tr><td align="left" valign="top" charoff="50">Timecourse samples</td><td align="center" valign="top" charoff="50">35</td><td align="center" valign="top" charoff="50">20</td><td align="center" valign="top" charoff="50">750</td><td align="center" valign="top" charoff="50">578</td><td align="center" valign="top" charoff="50">1,383</td></tr><tr><td align="left" valign="top" charoff="50">Tissues</td><td align="center" valign="top" charoff="50">152</td><td align="center" valign="top" charoff="50">236</td><td align="center" valign="top" charoff="50">36</td><td align="center" valign="top" charoff="50">45</td><td align="center" valign="top" charoff="50">469</td></tr><tr><td align="left" valign="top" charoff="50">Quality control samples</td><td align="center" valign="top" charoff="50">0</td><td align="center" valign="top" charoff="50">28</td><td align="center" valign="top" charoff="50">0</td><td align="center" valign="top" charoff="50">122</td><td align="center" valign="top" charoff="50">150</td></tr><tr><td align="left" valign="top" charoff="50">Total</td><td align="center" valign="top" charoff="50">998</td><td align="center" valign="top" charoff="50">395</td><td align="center" valign="top" charoff="50">831</td><td align="center" valign="top" charoff="50">795</td><td align="center" valign="top" charoff="50">3,019</td></tr></tbody></table></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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