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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hyperfractionated or Accelerated Radiotherapy in Lung Cancer: An Individual Patient Data Meta-Analysis</title><author><name sortKey="Mauguen, Audrey" sort="Mauguen, Audrey" uniqKey="Mauguen A" first="Audrey" last="Mauguen">Audrey Mauguen</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Le Pechoux, Cecile" sort="Le Pechoux, Cecile" uniqKey="Le Pechoux C" first="Cécile" last="Le Péchoux">Cécile Le Péchoux</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Saunders, Michele I" sort="Saunders, Michele I" uniqKey="Saunders M" first="Michele I." last="Saunders">Michele I. Saunders</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Schild, Steven E" sort="Schild, Steven E" uniqKey="Schild S" first="Steven E." last="Schild">Steven E. Schild</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Turrisi, Andrew T" sort="Turrisi, Andrew T" uniqKey="Turrisi A" first="Andrew T." last="Turrisi">Andrew T. Turrisi</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Baumann, Michael" sort="Baumann, Michael" uniqKey="Baumann M" first="Michael" last="Baumann">Michael Baumann</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Sause, William T" sort="Sause, William T" uniqKey="Sause W" first="William T." last="Sause">William T. Sause</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Ball, David" sort="Ball, David" uniqKey="Ball D" first="David" last="Ball">David Ball</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Belani, Chandra P" sort="Belani, Chandra P" uniqKey="Belani C" first="Chandra P." last="Belani">Chandra P. Belani</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Bonner, James A" sort="Bonner, James A" uniqKey="Bonner J" first="James A." last="Bonner">James A. Bonner</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Zajusz, Aleksander" sort="Zajusz, Aleksander" uniqKey="Zajusz A" first="Aleksander" last="Zajusz">Aleksander Zajusz</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Dahlberg, Suzanne E" sort="Dahlberg, Suzanne E" uniqKey="Dahlberg S" first="Suzanne E." last="Dahlberg">Suzanne E. Dahlberg</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Nankivell, Matthew" sort="Nankivell, Matthew" uniqKey="Nankivell M" first="Matthew" last="Nankivell">Matthew Nankivell</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Mandrekar, Sumithra J" sort="Mandrekar, Sumithra J" uniqKey="Mandrekar S" first="Sumithra J." last="Mandrekar">Sumithra J. Mandrekar</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Paulus, Rebecca" sort="Paulus, Rebecca" uniqKey="Paulus R" first="Rebecca" last="Paulus">Rebecca Paulus</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Behrendt, Katarzyna" sort="Behrendt, Katarzyna" uniqKey="Behrendt K" first="Katarzyna" last="Behrendt">Katarzyna Behrendt</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Koch, Rainer" sort="Koch, Rainer" uniqKey="Koch R" first="Rainer" last="Koch">Rainer Koch</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Bishop, James F" sort="Bishop, James F" uniqKey="Bishop J" first="James F." last="Bishop">James F. Bishop</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Dische, Stanley" sort="Dische, Stanley" uniqKey="Dische S" first="Stanley" last="Dische">Stanley Dische</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Arriagada, Rodrigo" sort="Arriagada, Rodrigo" uniqKey="Arriagada R" first="Rodrigo" last="Arriagada">Rodrigo Arriagada</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="De Ruysscher, Dirk" sort="De Ruysscher, Dirk" uniqKey="De Ruysscher D" first="Dirk" last="De Ruysscher">Dirk De Ruysscher</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Pignon, Jean Pierre" sort="Pignon, Jean Pierre" uniqKey="Pignon J" first="Jean-Pierre" last="Pignon">Jean-Pierre Pignon</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22753901</idno><idno type="pmc">4934452</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934452</idno><idno type="RBID">PMC:4934452</idno><idno type="doi">10.1200/JCO.2012.41.6677</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000652</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000652</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hyperfractionated or Accelerated Radiotherapy in Lung Cancer: An Individual Patient Data Meta-Analysis</title><author><name sortKey="Mauguen, Audrey" sort="Mauguen, Audrey" uniqKey="Mauguen A" first="Audrey" last="Mauguen">Audrey Mauguen</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Le Pechoux, Cecile" sort="Le Pechoux, Cecile" uniqKey="Le Pechoux C" first="Cécile" last="Le Péchoux">Cécile Le Péchoux</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Saunders, Michele I" sort="Saunders, Michele I" uniqKey="Saunders M" first="Michele I." last="Saunders">Michele I. Saunders</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Schild, Steven E" sort="Schild, Steven E" uniqKey="Schild S" first="Steven E." last="Schild">Steven E. Schild</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Turrisi, Andrew T" sort="Turrisi, Andrew T" uniqKey="Turrisi A" first="Andrew T." last="Turrisi">Andrew T. Turrisi</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Baumann, Michael" sort="Baumann, Michael" uniqKey="Baumann M" first="Michael" last="Baumann">Michael Baumann</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Sause, William T" sort="Sause, William T" uniqKey="Sause W" first="William T." last="Sause">William T. Sause</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Ball, David" sort="Ball, David" uniqKey="Ball D" first="David" last="Ball">David Ball</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Belani, Chandra P" sort="Belani, Chandra P" uniqKey="Belani C" first="Chandra P." last="Belani">Chandra P. Belani</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Bonner, James A" sort="Bonner, James A" uniqKey="Bonner J" first="James A." last="Bonner">James A. Bonner</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Zajusz, Aleksander" sort="Zajusz, Aleksander" uniqKey="Zajusz A" first="Aleksander" last="Zajusz">Aleksander Zajusz</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Dahlberg, Suzanne E" sort="Dahlberg, Suzanne E" uniqKey="Dahlberg S" first="Suzanne E." last="Dahlberg">Suzanne E. Dahlberg</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Nankivell, Matthew" sort="Nankivell, Matthew" uniqKey="Nankivell M" first="Matthew" last="Nankivell">Matthew Nankivell</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Mandrekar, Sumithra J" sort="Mandrekar, Sumithra J" uniqKey="Mandrekar S" first="Sumithra J." last="Mandrekar">Sumithra J. Mandrekar</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Paulus, Rebecca" sort="Paulus, Rebecca" uniqKey="Paulus R" first="Rebecca" last="Paulus">Rebecca Paulus</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Behrendt, Katarzyna" sort="Behrendt, Katarzyna" uniqKey="Behrendt K" first="Katarzyna" last="Behrendt">Katarzyna Behrendt</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Koch, Rainer" sort="Koch, Rainer" uniqKey="Koch R" first="Rainer" last="Koch">Rainer Koch</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Bishop, James F" sort="Bishop, James F" uniqKey="Bishop J" first="James F." last="Bishop">James F. Bishop</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Dische, Stanley" sort="Dische, Stanley" uniqKey="Dische S" first="Stanley" last="Dische">Stanley Dische</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Arriagada, Rodrigo" sort="Arriagada, Rodrigo" uniqKey="Arriagada R" first="Rodrigo" last="Arriagada">Rodrigo Arriagada</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="De Ruysscher, Dirk" sort="De Ruysscher, Dirk" uniqKey="De Ruysscher D" first="Dirk" last="De Ruysscher">Dirk De Ruysscher</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Pignon, Jean Pierre" sort="Pignon, Jean Pierre" uniqKey="Pignon J" first="Jean-Pierre" last="Pignon">Jean-Pierre Pignon</name><affiliation><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Oncology</title><idno type="ISSN">0732-183X</idno><idno type="eISSN">1527-7755</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>In lung cancer, randomized trials assessing hyperfractionated or accelerated radiotherapy seem to yield conflicting results regarding the effects on overall (OS) or progression-free survival (PFS). The Meta-Analysis of Radiotherapy in Lung Cancer Collaborative Group decided to address the role of modified radiotherapy fractionation.</p></sec><sec><title>Material and Methods</title><p>We performed an individual patient data meta-analysis in patients with nonmetastatic lung cancer, which included trials comparing modified radiotherapy with conventional radiotherapy.</p></sec><sec><title>Results</title><p>In non–small-cell lung cancer (NSCLC; 10 trials, 2,000 patients), modified fractionation improved OS as compared with conventional schedules (hazard ratio [HR] = 0.88, 95% CI, 0.80 to 0.97; <italic>P</italic> = .009), resulting in an absolute benefit of 2.5% (8.3% to 10.8%) at 5 years. No evidence of heterogeneity between trials was found. There was no evidence of a benefit on PFS (HR = 0.94; 95% CI, 0.86 to 1.03; <italic>P</italic> = .19). Modified radiotherapy reduced deaths resulting from lung cancer (HR = 0.89; 95% CI, 0.81 to 0.98; <italic>P</italic> = .02), and there was a nonsignificant reduction of non–lung cancer deaths (HR = 0.87; 95% CI, 0.66 to 1.15; <italic>P</italic> = .33). In small-cell lung cancer (SCLC; two trials, 685 patients), similar results were found: OS, HR = 0.87, 95% CI, 0.74 to 1.02, <italic>P</italic> = .08; PFS, HR = 0.88, 95% CI, 0.75 to 1.03, <italic>P</italic> = .11. In both NSCLC and SCLC, the use of modified radiotherapy increased the risk of acute esophageal toxicity (odds ratio [OR] = 2.44 in NSCLC and OR = 2.41 in SCLC; <italic>P</italic> < .001) but did not have an impact on the risk of other acute toxicities.</p></sec><sec><title>Conclusion</title><p>Patients with nonmetastatic NSCLC derived a significant OS benefit from accelerated or hyperfractionated radiotherapy; a similar but nonsignificant trend was observed for SCLC. As expected, there was increased acute esophageal toxicity.</p></sec></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Oncol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Oncol</journal-id><journal-id journal-id-type="hwp">jco</journal-id><journal-id journal-id-type="pmc">jco</journal-id><journal-id journal-id-type="publisher-id">JCO</journal-id><journal-title-group><journal-title>Journal of Clinical Oncology</journal-title></journal-title-group><issn pub-type="ppub">0732-183X</issn><issn pub-type="epub">1527-7755</issn><publisher><publisher-name>American Society of Clinical Oncology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22753901</article-id><article-id pub-id-type="pmc">4934452</article-id><article-id pub-id-type="publisher-id">R6677</article-id><article-id pub-id-type="doi">10.1200/JCO.2012.41.6677</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>Radn</subject><subject>Thor4</subject><subject>Fra</subject></subj-group><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Hyperfractionated or Accelerated Radiotherapy in Lung Cancer: An Individual Patient Data Meta-Analysis</article-title><alt-title alt-title-type="short">Hyperfractionated or Accelerated Radiotherapy in Lung Cancer</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mauguen</surname><given-names>Audrey</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Le Péchoux</surname><given-names>Cécile</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Saunders</surname><given-names>Michele I.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Schild</surname><given-names>Steven E.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Turrisi</surname><given-names>Andrew T.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Baumann</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Sause</surname><given-names>William T.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Ball</surname><given-names>David</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Belani</surname><given-names>Chandra P.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Bonner</surname><given-names>James A.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Zajusz</surname><given-names>Aleksander</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Dahlberg</surname><given-names>Suzanne E.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Nankivell</surname><given-names>Matthew</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Mandrekar</surname><given-names>Sumithra J.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Paulus</surname><given-names>Rebecca</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Behrendt</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Koch</surname><given-names>Rainer</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Bishop</surname><given-names>James F.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Dische</surname><given-names>Stanley</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Arriagada</surname><given-names>Rodrigo</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>De Ruysscher</surname><given-names>Dirk</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Pignon</surname><given-names>Jean-Pierre</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</aff></contrib-group><author-notes><corresp id="cor1">Corresponding author: Jean-Pierre Pignon, MD, PhD, Meta-Analysis Unit, Biostatistics and Epidemiology Department, Institut de Cancérologie Gustave Roussy, 114 Rue Edouard Vaillant, 94805 Villejuif Cedex, France; e-mail: <email>jppignon@igr.fr</email>.</corresp></author-notes><pub-date pub-type="ppub"><day>1</day><month>8</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>2</day><month>7</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>2</day><month>7</month><year>2012</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>30</volume><issue>22</issue><fpage>2788</fpage><lpage>2797</lpage><history><date date-type="received"><day>9</day><month>1</month><year>2012</year></date><date date-type="accepted"><day>3</day><month>5</month><year>2012</year></date></history><permissions><copyright-statement>© 2012 by American Society of Clinical Oncology</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zlj02212002788.pdf"></self-uri><self-uri content-type="alt-lang-pdf fr" xlink:type="simple" xlink:href="2788.french.pdf"></self-uri><abstract><sec><title>Purpose</title><p>In lung cancer, randomized trials assessing hyperfractionated or accelerated radiotherapy seem to yield conflicting results regarding the effects on overall (OS) or progression-free survival (PFS). The Meta-Analysis of Radiotherapy in Lung Cancer Collaborative Group decided to address the role of modified radiotherapy fractionation.</p></sec><sec><title>Material and Methods</title><p>We performed an individual patient data meta-analysis in patients with nonmetastatic lung cancer, which included trials comparing modified radiotherapy with conventional radiotherapy.</p></sec><sec><title>Results</title><p>In non–small-cell lung cancer (NSCLC; 10 trials, 2,000 patients), modified fractionation improved OS as compared with conventional schedules (hazard ratio [HR] = 0.88, 95% CI, 0.80 to 0.97; <italic>P</italic> = .009), resulting in an absolute benefit of 2.5% (8.3% to 10.8%) at 5 years. No evidence of heterogeneity between trials was found. There was no evidence of a benefit on PFS (HR = 0.94; 95% CI, 0.86 to 1.03; <italic>P</italic> = .19). Modified radiotherapy reduced deaths resulting from lung cancer (HR = 0.89; 95% CI, 0.81 to 0.98; <italic>P</italic> = .02), and there was a nonsignificant reduction of non–lung cancer deaths (HR = 0.87; 95% CI, 0.66 to 1.15; <italic>P</italic> = .33). In small-cell lung cancer (SCLC; two trials, 685 patients), similar results were found: OS, HR = 0.87, 95% CI, 0.74 to 1.02, <italic>P</italic> = .08; PFS, HR = 0.88, 95% CI, 0.75 to 1.03, <italic>P</italic> = .11. In both NSCLC and SCLC, the use of modified radiotherapy increased the risk of acute esophageal toxicity (odds ratio [OR] = 2.44 in NSCLC and OR = 2.41 in SCLC; <italic>P</italic> < .001) but did not have an impact on the risk of other acute toxicities.</p></sec><sec><title>Conclusion</title><p>Patients with nonmetastatic NSCLC derived a significant OS benefit from accelerated or hyperfractionated radiotherapy; a similar but nonsignificant trend was observed for SCLC. As expected, there was increased acute esophageal toxicity.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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