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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013</title><author><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name><affiliation><nlm:aff id="aff1">Department of Hematology “L. and A. Seràgnoli,” S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy;</nlm:aff></affiliation></author><author><name sortKey="Deininger, Michael W" sort="Deininger, Michael W" uniqKey="Deininger M" first="Michael W." last="Deininger">Michael W. Deininger</name><affiliation><nlm:aff id="aff2">Division of Hematology and Hematologic Malignancies, University of Utah Huntsman Cancer Institute, Salt Lake City, UT;</nlm:aff></affiliation></author><author><name sortKey="Rosti, Gianantonio" sort="Rosti, Gianantonio" uniqKey="Rosti G" first="Gianantonio" last="Rosti">Gianantonio Rosti</name><affiliation><nlm:aff id="aff3">Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna, Italy;</nlm:aff></affiliation></author><author><name sortKey="Hochhaus, Andreas" sort="Hochhaus, Andreas" uniqKey="Hochhaus A" first="Andreas" last="Hochhaus">Andreas Hochhaus</name><affiliation><nlm:aff id="aff4">Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany;</nlm:aff></affiliation></author><author><name sortKey="Soverini, Simona" sort="Soverini, Simona" uniqKey="Soverini S" first="Simona" last="Soverini">Simona Soverini</name><affiliation><nlm:aff id="aff3">Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna, Italy;</nlm:aff></affiliation></author><author><name sortKey="Apperley, Jane F" sort="Apperley, Jane F" uniqKey="Apperley J" first="Jane F." last="Apperley">Jane F. Apperley</name><affiliation><nlm:aff id="aff5">Centre for Hematology, Imperial College, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Cervantes, Francisco" sort="Cervantes, Francisco" uniqKey="Cervantes F" first="Francisco" last="Cervantes">Francisco Cervantes</name><affiliation><nlm:aff id="aff6">Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain;</nlm:aff></affiliation></author><author><name sortKey="Clark, Richard E" sort="Clark, Richard E" uniqKey="Clark R" first="Richard E." last="Clark">Richard E. Clark</name><affiliation><nlm:aff id="aff7">Royal Liverpool University Hospital, Liverpool, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Cortes, Jorge E" sort="Cortes, Jorge E" uniqKey="Cortes J" first="Jorge E." last="Cortes">Jorge E. Cortes</name><affiliation><nlm:aff id="aff8">Department of Leukemia, MD Anderson Cancer Center, Houston, TX;</nlm:aff></affiliation></author><author><name sortKey="Guilhot, Francois" sort="Guilhot, Francois" uniqKey="Guilhot F" first="François" last="Guilhot">François Guilhot</name><affiliation><nlm:aff id="aff9">Institut National de la Santé et de la Recherche Médicale Centres d'investigation clinique 0802, CHU de Poitiers, Université de Poitiers, Poitiers, France;</nlm:aff></affiliation></author><author><name sortKey="Hjorth Hansen, Henrik" sort="Hjorth Hansen, Henrik" uniqKey="Hjorth Hansen H" first="Henrik" last="Hjorth-Hansen">Henrik Hjorth-Hansen</name><affiliation><nlm:aff id="aff10">Department of Hematology, St. Olavs Hospital, and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway;</nlm:aff></affiliation></author><author><name sortKey="Hughes, Timothy P" sort="Hughes, Timothy P" uniqKey="Hughes T" first="Timothy P." last="Hughes">Timothy P. Hughes</name><affiliation><nlm:aff id="aff11">SA Pathology and University of Adelaide, Adelaide, SA, Australia;</nlm:aff></affiliation></author><author><name sortKey="Kantarjian, Hagop M" sort="Kantarjian, Hagop M" uniqKey="Kantarjian H" first="Hagop M." last="Kantarjian">Hagop M. Kantarjian</name><affiliation><nlm:aff id="aff8">Department of Leukemia, MD Anderson Cancer Center, Houston, TX;</nlm:aff></affiliation></author><author><name sortKey="Kim, Dong Wook" sort="Kim, Dong Wook" uniqKey="Kim D" first="Dong-Wook" last="Kim">Dong-Wook Kim</name><affiliation><nlm:aff id="aff12">Department of Hematology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea;</nlm:aff></affiliation></author><author><name sortKey="Larson, Richard A" sort="Larson, Richard A" uniqKey="Larson R" first="Richard A." last="Larson">Richard A. Larson</name><affiliation><nlm:aff id="aff13">The University of Chicago, Chicago, IL;</nlm:aff></affiliation></author><author><name sortKey="Lipton, Jeffrey H" sort="Lipton, Jeffrey H" uniqKey="Lipton J" first="Jeffrey H." last="Lipton">Jeffrey H. Lipton</name><affiliation><nlm:aff id="aff14">Princess Margaret Hospital, University of Toronto, ON, Canada,</nlm:aff></affiliation></author><author><name sortKey="Mahon, Francois Xavier" sort="Mahon, Francois Xavier" uniqKey="Mahon F" first="François-Xavier" last="Mahon">François-Xavier Mahon</name><affiliation><nlm:aff id="aff15">Laboratoire d’ Hématologie CHU de Bordeaux et Laboratoire Hématopoïese Leucémique et Cible Therapeutique, Université Bordeaux Ségalen, Institut National de la Santé et de la Recherche Médicale 1035, Bordeaux, France;</nlm:aff></affiliation></author><author><name sortKey="Martinelli, Giovanni" sort="Martinelli, Giovanni" uniqKey="Martinelli G" first="Giovanni" last="Martinelli">Giovanni Martinelli</name><affiliation><nlm:aff id="aff3">Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna, Italy;</nlm:aff></affiliation></author><author><name sortKey="Mayer, Jiri" sort="Mayer, Jiri" uniqKey="Mayer J" first="Jiri" last="Mayer">Jiri Mayer</name><affiliation><nlm:aff id="aff16">University Hospital Brno and Central European Institute of Technology Masaryk University, Brno, Czech Republic;</nlm:aff></affiliation></author><author><name sortKey="Muller, Martin C" sort="Muller, Martin C" uniqKey="Muller M" first="Martin C." last="Müller">Martin C. Müller</name><affiliation><nlm:aff id="aff17">III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;</nlm:aff></affiliation></author><author><name sortKey="Niederwieser, Dietger" sort="Niederwieser, Dietger" uniqKey="Niederwieser D" first="Dietger" last="Niederwieser">Dietger Niederwieser</name><affiliation><nlm:aff id="aff18">Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation></author><author><name sortKey="Pane, Fabrizio" sort="Pane, Fabrizio" uniqKey="Pane F" first="Fabrizio" last="Pane">Fabrizio Pane</name><affiliation><nlm:aff id="aff19">Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, and CEINGE Biotecnologie Avanzate, Napoli, Italy;</nlm:aff></affiliation></author><author><name sortKey="Radich, Jerald P" sort="Radich, Jerald P" uniqKey="Radich J" first="Jerald P." last="Radich">Jerald P. Radich</name><affiliation><nlm:aff id="aff20">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Rousselot, Philippe" sort="Rousselot, Philippe" uniqKey="Rousselot P" first="Philippe" last="Rousselot">Philippe Rousselot</name><affiliation><nlm:aff id="aff21">Service d’ Hématologie et d’ Oncologie, Hôpital Mignot, Université Versailles Saint-Qentin-en-Yvelines, Versailles, France;</nlm:aff></affiliation></author><author><name sortKey="Saglio, Giuseppe" sort="Saglio, Giuseppe" uniqKey="Saglio G" first="Giuseppe" last="Saglio">Giuseppe Saglio</name><affiliation><nlm:aff id="aff22">Department of Oncology, University of Turin, Turin, Italy;</nlm:aff></affiliation></author><author><name sortKey="Sau Ele, Susanne" sort="Sau Ele, Susanne" uniqKey="Sau Ele S" first="Susanne" last="Sau Ele">Susanne Sau Ele</name><affiliation><nlm:aff id="aff17">III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;</nlm:aff></affiliation></author><author><name sortKey="Schiffer, Charles" sort="Schiffer, Charles" uniqKey="Schiffer C" first="Charles" last="Schiffer">Charles Schiffer</name><affiliation><nlm:aff id="aff23">Division of Medicine and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI;</nlm:aff></affiliation></author><author><name sortKey="Silver, Richard" sort="Silver, Richard" uniqKey="Silver R" first="Richard" last="Silver">Richard Silver</name><affiliation><nlm:aff id="aff24">Weill Cornell Medical College, New York, NY;</nlm:aff></affiliation></author><author><name sortKey="Simonsson, Bengt" sort="Simonsson, Bengt" uniqKey="Simonsson B" first="Bengt" last="Simonsson">Bengt Simonsson</name><affiliation><nlm:aff id="aff25">University Hospital, Uppsala, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Steegmann, Juan Luis" sort="Steegmann, Juan Luis" uniqKey="Steegmann J" first="Juan-Luis" last="Steegmann">Juan-Luis Steegmann</name><affiliation><nlm:aff wicri:cut="; and" id="aff26">Servicio de Hematologia, Hospital Universitario de la Princesa, IIS-IP, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Goldman, John M" sort="Goldman, John M" uniqKey="Goldman J" first="John M." last="Goldman">John M. Goldman</name><affiliation><nlm:aff id="aff27">Department of Hematology, Imperial College, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hehlmann, Rudiger" sort="Hehlmann, Rudiger" uniqKey="Hehlmann R" first="Rüdiger" last="Hehlmann">Rüdiger Hehlmann</name><affiliation><nlm:aff id="aff17">III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23803709</idno><idno type="pmc">4915804</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915804</idno><idno type="RBID">PMC:4915804</idno><idno type="doi">10.1182/blood-2013-05-501569</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000649</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000649</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013</title><author><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name><affiliation><nlm:aff id="aff1">Department of Hematology “L. and A. Seràgnoli,” S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy;</nlm:aff></affiliation></author><author><name sortKey="Deininger, Michael W" sort="Deininger, Michael W" uniqKey="Deininger M" first="Michael W." last="Deininger">Michael W. Deininger</name><affiliation><nlm:aff id="aff2">Division of Hematology and Hematologic Malignancies, University of Utah Huntsman Cancer Institute, Salt Lake City, UT;</nlm:aff></affiliation></author><author><name sortKey="Rosti, Gianantonio" sort="Rosti, Gianantonio" uniqKey="Rosti G" first="Gianantonio" last="Rosti">Gianantonio Rosti</name><affiliation><nlm:aff id="aff3">Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna, Italy;</nlm:aff></affiliation></author><author><name sortKey="Hochhaus, Andreas" sort="Hochhaus, Andreas" uniqKey="Hochhaus A" first="Andreas" last="Hochhaus">Andreas Hochhaus</name><affiliation><nlm:aff id="aff4">Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany;</nlm:aff></affiliation></author><author><name sortKey="Soverini, Simona" sort="Soverini, Simona" uniqKey="Soverini S" first="Simona" last="Soverini">Simona Soverini</name><affiliation><nlm:aff id="aff3">Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna, Italy;</nlm:aff></affiliation></author><author><name sortKey="Apperley, Jane F" sort="Apperley, Jane F" uniqKey="Apperley J" first="Jane F." last="Apperley">Jane F. Apperley</name><affiliation><nlm:aff id="aff5">Centre for Hematology, Imperial College, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Cervantes, Francisco" sort="Cervantes, Francisco" uniqKey="Cervantes F" first="Francisco" last="Cervantes">Francisco Cervantes</name><affiliation><nlm:aff id="aff6">Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain;</nlm:aff></affiliation></author><author><name sortKey="Clark, Richard E" sort="Clark, Richard E" uniqKey="Clark R" first="Richard E." last="Clark">Richard E. Clark</name><affiliation><nlm:aff id="aff7">Royal Liverpool University Hospital, Liverpool, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Cortes, Jorge E" sort="Cortes, Jorge E" uniqKey="Cortes J" first="Jorge E." last="Cortes">Jorge E. Cortes</name><affiliation><nlm:aff id="aff8">Department of Leukemia, MD Anderson Cancer Center, Houston, TX;</nlm:aff></affiliation></author><author><name sortKey="Guilhot, Francois" sort="Guilhot, Francois" uniqKey="Guilhot F" first="François" last="Guilhot">François Guilhot</name><affiliation><nlm:aff id="aff9">Institut National de la Santé et de la Recherche Médicale Centres d'investigation clinique 0802, CHU de Poitiers, Université de Poitiers, Poitiers, France;</nlm:aff></affiliation></author><author><name sortKey="Hjorth Hansen, Henrik" sort="Hjorth Hansen, Henrik" uniqKey="Hjorth Hansen H" first="Henrik" last="Hjorth-Hansen">Henrik Hjorth-Hansen</name><affiliation><nlm:aff id="aff10">Department of Hematology, St. Olavs Hospital, and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway;</nlm:aff></affiliation></author><author><name sortKey="Hughes, Timothy P" sort="Hughes, Timothy P" uniqKey="Hughes T" first="Timothy P." last="Hughes">Timothy P. Hughes</name><affiliation><nlm:aff id="aff11">SA Pathology and University of Adelaide, Adelaide, SA, Australia;</nlm:aff></affiliation></author><author><name sortKey="Kantarjian, Hagop M" sort="Kantarjian, Hagop M" uniqKey="Kantarjian H" first="Hagop M." last="Kantarjian">Hagop M. Kantarjian</name><affiliation><nlm:aff id="aff8">Department of Leukemia, MD Anderson Cancer Center, Houston, TX;</nlm:aff></affiliation></author><author><name sortKey="Kim, Dong Wook" sort="Kim, Dong Wook" uniqKey="Kim D" first="Dong-Wook" last="Kim">Dong-Wook Kim</name><affiliation><nlm:aff id="aff12">Department of Hematology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea;</nlm:aff></affiliation></author><author><name sortKey="Larson, Richard A" sort="Larson, Richard A" uniqKey="Larson R" first="Richard A." last="Larson">Richard A. Larson</name><affiliation><nlm:aff id="aff13">The University of Chicago, Chicago, IL;</nlm:aff></affiliation></author><author><name sortKey="Lipton, Jeffrey H" sort="Lipton, Jeffrey H" uniqKey="Lipton J" first="Jeffrey H." last="Lipton">Jeffrey H. Lipton</name><affiliation><nlm:aff id="aff14">Princess Margaret Hospital, University of Toronto, ON, Canada,</nlm:aff></affiliation></author><author><name sortKey="Mahon, Francois Xavier" sort="Mahon, Francois Xavier" uniqKey="Mahon F" first="François-Xavier" last="Mahon">François-Xavier Mahon</name><affiliation><nlm:aff id="aff15">Laboratoire d’ Hématologie CHU de Bordeaux et Laboratoire Hématopoïese Leucémique et Cible Therapeutique, Université Bordeaux Ségalen, Institut National de la Santé et de la Recherche Médicale 1035, Bordeaux, France;</nlm:aff></affiliation></author><author><name sortKey="Martinelli, Giovanni" sort="Martinelli, Giovanni" uniqKey="Martinelli G" first="Giovanni" last="Martinelli">Giovanni Martinelli</name><affiliation><nlm:aff id="aff3">Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna, Italy;</nlm:aff></affiliation></author><author><name sortKey="Mayer, Jiri" sort="Mayer, Jiri" uniqKey="Mayer J" first="Jiri" last="Mayer">Jiri Mayer</name><affiliation><nlm:aff id="aff16">University Hospital Brno and Central European Institute of Technology Masaryk University, Brno, Czech Republic;</nlm:aff></affiliation></author><author><name sortKey="Muller, Martin C" sort="Muller, Martin C" uniqKey="Muller M" first="Martin C." last="Müller">Martin C. Müller</name><affiliation><nlm:aff id="aff17">III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;</nlm:aff></affiliation></author><author><name sortKey="Niederwieser, Dietger" sort="Niederwieser, Dietger" uniqKey="Niederwieser D" first="Dietger" last="Niederwieser">Dietger Niederwieser</name><affiliation><nlm:aff id="aff18">Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation></author><author><name sortKey="Pane, Fabrizio" sort="Pane, Fabrizio" uniqKey="Pane F" first="Fabrizio" last="Pane">Fabrizio Pane</name><affiliation><nlm:aff id="aff19">Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, and CEINGE Biotecnologie Avanzate, Napoli, Italy;</nlm:aff></affiliation></author><author><name sortKey="Radich, Jerald P" sort="Radich, Jerald P" uniqKey="Radich J" first="Jerald P." last="Radich">Jerald P. Radich</name><affiliation><nlm:aff id="aff20">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Rousselot, Philippe" sort="Rousselot, Philippe" uniqKey="Rousselot P" first="Philippe" last="Rousselot">Philippe Rousselot</name><affiliation><nlm:aff id="aff21">Service d’ Hématologie et d’ Oncologie, Hôpital Mignot, Université Versailles Saint-Qentin-en-Yvelines, Versailles, France;</nlm:aff></affiliation></author><author><name sortKey="Saglio, Giuseppe" sort="Saglio, Giuseppe" uniqKey="Saglio G" first="Giuseppe" last="Saglio">Giuseppe Saglio</name><affiliation><nlm:aff id="aff22">Department of Oncology, University of Turin, Turin, Italy;</nlm:aff></affiliation></author><author><name sortKey="Sau Ele, Susanne" sort="Sau Ele, Susanne" uniqKey="Sau Ele S" first="Susanne" last="Sau Ele">Susanne Sau Ele</name><affiliation><nlm:aff id="aff17">III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;</nlm:aff></affiliation></author><author><name sortKey="Schiffer, Charles" sort="Schiffer, Charles" uniqKey="Schiffer C" first="Charles" last="Schiffer">Charles Schiffer</name><affiliation><nlm:aff id="aff23">Division of Medicine and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI;</nlm:aff></affiliation></author><author><name sortKey="Silver, Richard" sort="Silver, Richard" uniqKey="Silver R" first="Richard" last="Silver">Richard Silver</name><affiliation><nlm:aff id="aff24">Weill Cornell Medical College, New York, NY;</nlm:aff></affiliation></author><author><name sortKey="Simonsson, Bengt" sort="Simonsson, Bengt" uniqKey="Simonsson B" first="Bengt" last="Simonsson">Bengt Simonsson</name><affiliation><nlm:aff id="aff25">University Hospital, Uppsala, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Steegmann, Juan Luis" sort="Steegmann, Juan Luis" uniqKey="Steegmann J" first="Juan-Luis" last="Steegmann">Juan-Luis Steegmann</name><affiliation><nlm:aff wicri:cut="; and" id="aff26">Servicio de Hematologia, Hospital Universitario de la Princesa, IIS-IP, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Goldman, John M" sort="Goldman, John M" uniqKey="Goldman J" first="John M." last="Goldman">John M. Goldman</name><affiliation><nlm:aff id="aff27">Department of Hematology, Imperial College, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hehlmann, Rudiger" sort="Hehlmann, Rudiger" uniqKey="Hehlmann R" first="Rüdiger" last="Hehlmann">Rüdiger Hehlmann</name><affiliation><nlm:aff id="aff17">III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;</nlm:aff></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Advances in chronic myeloid leukemia treatment, particularly regarding tyrosine kinase inhibitors, mandate regular updating of concepts and management. A European LeukemiaNet expert panel reviewed prior and new studies to update recommendations made in 2009. We recommend as initial treatment imatinib, nilotinib, or dasatinib. Response is assessed with standardized real quantitative polymerase chain reaction and/or cytogenetics at 3, 6, and 12 months. BCR-ABL1 transcript levels ≤10% at 3 months, <1% at 6 months, and ≤0.1% from 12 months onward define optimal response, whereas >10% at 6 months and >1% from 12 months onward define failure, mandating a change in treatment. Similarly, partial cytogenetic response (PCyR) at 3 months and complete cytogenetic response (CCyR) from 6 months onward define optimal response, whereas no CyR (Philadelphia chromosome–positive [Ph+] >95%) at 3 months, less than PCyR at 6 months, and less than CCyR from 12 months onward define failure. Between optimal and failure, there is an intermediate warning zone requiring more frequent monitoring. Similar definitions are provided for response to second-line therapy. Specific recommendations are made for patients in the accelerated and blastic phases, and for allogeneic stem cell transplantation. Optimal responders should continue therapy indefinitely, with careful surveillance, or they can be enrolled in controlled studies of treatment discontinuation once a deeper molecular response is achieved.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id><journal-id journal-id-type="iso-abbrev">Blood</journal-id><journal-id journal-id-type="hwp">bloodjournal</journal-id><journal-id journal-id-type="pmc">blood</journal-id><journal-id journal-id-type="publisher-id">Blood</journal-id><journal-title-group><journal-title>Blood</journal-title></journal-title-group><issn pub-type="ppub">0006-4971</issn><issn pub-type="epub">1528-0020</issn><publisher><publisher-name>American Society of Hematology</publisher-name><publisher-loc>Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23803709</article-id><article-id pub-id-type="pmc">4915804</article-id><article-id pub-id-type="publisher-id">2013/501569</article-id><article-id pub-id-type="doi">10.1182/blood-2013-05-501569</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Baccarani</surname><given-names>Michele</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Deininger</surname><given-names>Michael W.</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Rosti</surname><given-names>Gianantonio</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hochhaus</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Soverini</surname><given-names>Simona</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Apperley</surname><given-names>Jane F.</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Cervantes</surname><given-names>Francisco</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Clark</surname><given-names>Richard E.</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Cortes</surname><given-names>Jorge E.</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Guilhot</surname><given-names>François</given-names></name><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Hjorth-Hansen</surname><given-names>Henrik</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Hughes</surname><given-names>Timothy P.</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Kantarjian</surname><given-names>Hagop M.</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Dong-Wook</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Larson</surname><given-names>Richard A.</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Lipton</surname><given-names>Jeffrey H.</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Mahon</surname><given-names>François-Xavier</given-names></name><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Martinelli</surname><given-names>Giovanni</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Mayer</surname><given-names>Jiri</given-names></name><xref ref-type="aff" rid="aff16">16</xref></contrib><contrib contrib-type="author"><name><surname>Müller</surname><given-names>Martin C.</given-names></name><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>Niederwieser</surname><given-names>Dietger</given-names></name><xref ref-type="aff" rid="aff18">18</xref></contrib><contrib contrib-type="author"><name><surname>Pane</surname><given-names>Fabrizio</given-names></name><xref ref-type="aff" rid="aff19">19</xref></contrib><contrib contrib-type="author"><name><surname>Radich</surname><given-names>Jerald P.</given-names></name><xref ref-type="aff" rid="aff20">20</xref></contrib><contrib contrib-type="author"><name><surname>Rousselot</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="aff21">21</xref></contrib><contrib contrib-type="author"><name><surname>Saglio</surname><given-names>Giuseppe</given-names></name><xref ref-type="aff" rid="aff22">22</xref></contrib><contrib contrib-type="author"><name><surname>Saußele</surname><given-names>Susanne</given-names></name><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>Schiffer</surname><given-names>Charles</given-names></name><xref ref-type="aff" rid="aff23">23</xref></contrib><contrib contrib-type="author"><name><surname>Silver</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="aff24">24</xref></contrib><contrib contrib-type="author"><name><surname>Simonsson</surname><given-names>Bengt</given-names></name><xref ref-type="aff" rid="aff25">25</xref></contrib><contrib contrib-type="author"><name><surname>Steegmann</surname><given-names>Juan-Luis</given-names></name><xref ref-type="aff" rid="aff26">26</xref></contrib><contrib contrib-type="author"><name><surname>Goldman</surname><given-names>John M.</given-names></name><xref ref-type="aff" rid="aff27">27</xref></contrib><contrib contrib-type="author"><name><surname>Hehlmann</surname><given-names>Rüdiger</given-names></name><xref ref-type="aff" rid="aff17">17</xref></contrib><aff id="aff1"><label>1</label>Department of Hematology “L. and A. Seràgnoli,” S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy;</aff><aff id="aff2"><label>2</label>Division of Hematology and Hematologic Malignancies, University of Utah Huntsman Cancer Institute, Salt Lake City, UT;</aff><aff id="aff3"><label>3</label>Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna, Italy;</aff><aff id="aff4"><label>4</label>Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany;</aff><aff id="aff5"><label>5</label>Centre for Hematology, Imperial College, London, United Kingdom;</aff><aff id="aff6"><label>6</label>Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain;</aff><aff id="aff7"><label>7</label>Royal Liverpool University Hospital, Liverpool, United Kingdom;</aff><aff id="aff8"><label>8</label>Department of Leukemia, MD Anderson Cancer Center, Houston, TX;</aff><aff id="aff9"><label>9</label>Institut National de la Santé et de la Recherche Médicale Centres d'investigation clinique 0802, CHU de Poitiers, Université de Poitiers, Poitiers, France;</aff><aff id="aff10"><label>10</label>Department of Hematology, St. Olavs Hospital, and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway;</aff><aff id="aff11"><label>11</label>SA Pathology and University of Adelaide, Adelaide, SA, Australia;</aff><aff id="aff12"><label>12</label>Department of Hematology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea;</aff><aff id="aff13"><label>13</label>The University of Chicago, Chicago, IL;</aff><aff id="aff14"><label>14</label>Princess Margaret Hospital, University of Toronto, ON, Canada,</aff><aff id="aff15"><label>15</label>Laboratoire d’ Hématologie CHU de Bordeaux et Laboratoire Hématopoïese Leucémique et Cible Therapeutique, Université Bordeaux Ségalen, Institut National de la Santé et de la Recherche Médicale 1035, Bordeaux, France;</aff><aff id="aff16"><label>16</label>University Hospital Brno and Central European Institute of Technology Masaryk University, Brno, Czech Republic;</aff><aff id="aff17"><label>17</label>III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;</aff><aff id="aff18"><label>18</label>Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany;</aff><aff id="aff19"><label>19</label>Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, and CEINGE Biotecnologie Avanzate, Napoli, Italy;</aff><aff id="aff20"><label>20</label>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;</aff><aff id="aff21"><label>21</label>Service d’ Hématologie et d’ Oncologie, Hôpital Mignot, Université Versailles Saint-Qentin-en-Yvelines, Versailles, France;</aff><aff id="aff22"><label>22</label>Department of Oncology, University of Turin, Turin, Italy;</aff><aff id="aff23"><label>23</label>Division of Medicine and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI;</aff><aff id="aff24"><label>24</label>Weill Cornell Medical College, New York, NY;</aff><aff id="aff25"><label>25</label>University Hospital, Uppsala, Sweden;</aff><aff id="aff26"><label>26</label>Servicio de Hematologia, Hospital Universitario de la Princesa, IIS-IP, Madrid, Spain; and</aff><aff id="aff27"><label>27</label>Department of Hematology, Imperial College, London, United Kingdom</aff></contrib-group><pub-date pub-type="ppub"><day>08</day><month>8</month><year>2013</year></pub-date><pub-date pub-type="epreprint"><day>26</day><month>6</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>08</day><month>8</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>122</volume><issue>6</issue><fpage>872</fpage><lpage>884</lpage><history><date date-type="received"><day>08</day><month>5</month><year>2013</year></date><date date-type="accepted"><day>10</day><month>6</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 by The American Society of Hematology</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="872.pdf"></self-uri><abstract><p>Advances in chronic myeloid leukemia treatment, particularly regarding tyrosine kinase inhibitors, mandate regular updating of concepts and management. A European LeukemiaNet expert panel reviewed prior and new studies to update recommendations made in 2009. We recommend as initial treatment imatinib, nilotinib, or dasatinib. Response is assessed with standardized real quantitative polymerase chain reaction and/or cytogenetics at 3, 6, and 12 months. BCR-ABL1 transcript levels ≤10% at 3 months, <1% at 6 months, and ≤0.1% from 12 months onward define optimal response, whereas >10% at 6 months and >1% from 12 months onward define failure, mandating a change in treatment. Similarly, partial cytogenetic response (PCyR) at 3 months and complete cytogenetic response (CCyR) from 6 months onward define optimal response, whereas no CyR (Philadelphia chromosome–positive [Ph+] >95%) at 3 months, less than PCyR at 6 months, and less than CCyR from 12 months onward define failure. Between optimal and failure, there is an intermediate warning zone requiring more frequent monitoring. Similar definitions are provided for response to second-line therapy. Specific recommendations are made for patients in the accelerated and blastic phases, and for allogeneic stem cell transplantation. Optimal responders should continue therapy indefinitely, with careful surveillance, or they can be enrolled in controlled studies of treatment discontinuation once a deeper molecular response is achieved.</p></abstract><counts><page-count count="13"></page-count></counts><custom-meta-group><custom-meta><meta-name>access</meta-name><meta-value>free</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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