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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cost of management of severe pneumonia in young children: systematic analysis</title><author><name sortKey="Zhang, Shanshan" sort="Zhang, Shanshan" uniqKey="Zhang S" first="Shanshan" last="Zhang">Shanshan Zhang</name><affiliation><nlm:aff id="aff1">Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Preventive Dentistry, Peking University, School and Hospital of Stomatology, Beijing, PR China</nlm:aff></affiliation></author><author><name sortKey="Sammon, Peter M" sort="Sammon, Peter M" uniqKey="Sammon P" first="Peter M." last="Sammon">Peter M. Sammon</name><affiliation><nlm:aff id="aff1">Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="King, Isobel" sort="King, Isobel" uniqKey="King I" first="Isobel" last="King">Isobel King</name><affiliation><nlm:aff id="aff1">Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">NHS Grampian, UK</nlm:aff></affiliation></author><author><name sortKey="Andrade, Ana Lucia" sort="Andrade, Ana Lucia" uniqKey="Andrade A" first="Ana Lucia" last="Andrade">Ana Lucia Andrade</name><affiliation><nlm:aff id="aff4">Department of Community Health, Federal University of Goias, Brazil</nlm:aff></affiliation></author><author><name sortKey="Toscano, Cristiana M" sort="Toscano, Cristiana M" uniqKey="Toscano C" first="Cristiana M." last="Toscano">Cristiana M. Toscano</name><affiliation><nlm:aff id="aff4">Department of Community Health, Federal University of Goias, Brazil</nlm:aff></affiliation></author><author><name sortKey="Araujo, Sheila N" sort="Araujo, Sheila N" uniqKey="Araujo S" first="Sheila N" last="Araujo">Sheila N. Araujo</name><affiliation><nlm:aff id="aff4">Department of Community Health, Federal University of Goias, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">State University of Maranhăo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Sinha, Anushua" sort="Sinha, Anushua" uniqKey="Sinha A" first="Anushua" last="Sinha">Anushua Sinha</name><affiliation><nlm:aff id="aff6">New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey USA</nlm:aff></affiliation></author><author><name sortKey="Madhi, Shabir A" sort="Madhi, Shabir A" uniqKey="Madhi S" first="Shabir A." last="Madhi">Shabir A. Madhi</name><affiliation><nlm:aff id="aff7">Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="aff8">Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation></author><author><name sortKey="Khandaker, Gulam" sort="Khandaker, Gulam" uniqKey="Khandaker G" first="Gulam" last="Khandaker">Gulam Khandaker</name><affiliation><nlm:aff id="aff9">National Centre for Immunisation Research and Surveillance, The Children's Hospital at Westmead, NSW, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Sydney School of Public Health, Faculty of Medicine, The University of Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Yin, Jiehui Kevin" sort="Yin, Jiehui Kevin" uniqKey="Yin J" first="Jiehui Kevin" last="Yin">Jiehui Kevin Yin</name><affiliation><nlm:aff id="aff9">National Centre for Immunisation Research and Surveillance, The Children's Hospital at Westmead, NSW, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Sydney School of Public Health, Faculty of Medicine, The University of Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Booy, Robert" sort="Booy, Robert" uniqKey="Booy R" first="Robert" last="Booy">Robert Booy</name><affiliation><nlm:aff id="aff9">National Centre for Immunisation Research and Surveillance, The Children's Hospital at Westmead, NSW, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Sydney School of Public Health, Faculty of Medicine, The University of Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Huda, Tanvir M" sort="Huda, Tanvir M" uniqKey="Huda T" first="Tanvir M" last="Huda">Tanvir M. Huda</name><affiliation><nlm:aff id="aff11">Centre for Child and Adolescent Health, icddr,b, Dhaka, Bangladesh</nlm:aff></affiliation><affiliation><nlm:aff id="aff12">School of Public Health, Sydney Medical School, University of Sydney, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Rahman, Qazi S" sort="Rahman, Qazi S" uniqKey="Rahman Q" first="Qazi S" last="Rahman">Qazi S. Rahman</name><affiliation><nlm:aff id="aff11">Centre for Child and Adolescent Health, icddr,b, Dhaka, Bangladesh</nlm:aff></affiliation></author><author><name sortKey="El Arifeen, Shams" sort="El Arifeen, Shams" uniqKey="El Arifeen S" first="Shams" last="El Arifeen">Shams El Arifeen</name><affiliation><nlm:aff id="aff11">Centre for Child and Adolescent Health, icddr,b, Dhaka, Bangladesh</nlm:aff></affiliation></author><author><name sortKey="Gentile, Angela" sort="Gentile, Angela" uniqKey="Gentile A" first="Angela" last="Gentile">Angela Gentile</name><affiliation><nlm:aff id="aff13">Epidemiology Department, Ricardo Gutierrez Children Hospital, University of Buenos Aires, Argentina</nlm:aff></affiliation></author><author><name sortKey="Giglio, Norberto" sort="Giglio, Norberto" uniqKey="Giglio N" first="Norberto" last="Giglio">Norberto Giglio</name><affiliation><nlm:aff id="aff13">Epidemiology Department, Ricardo Gutierrez Children Hospital, University of Buenos Aires, Argentina</nlm:aff></affiliation></author><author><name sortKey="Bhuiyan, Mejbah U" sort="Bhuiyan, Mejbah U" uniqKey="Bhuiyan M" first="Mejbah U." last="Bhuiyan">Mejbah U. Bhuiyan</name><affiliation><nlm:aff id="aff14">Centre for Communicable Diseases, icddr,b, Dhaka, Bangladesh</nlm:aff></affiliation></author><author><name sortKey="Sturm Amirez, Katharine" sort="Sturm Amirez, Katharine" uniqKey="Sturm Amirez K" first="Katharine" last="Sturm Amirez">Katharine Sturm Amirez</name><affiliation><nlm:aff id="aff14">Centre for Communicable Diseases, icddr,b, Dhaka, Bangladesh</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Gessner, Bradford D" sort="Gessner, Bradford D" uniqKey="Gessner B" first="Bradford D." last="Gessner">Bradford D. Gessner</name><affiliation><nlm:aff id="aff16">Agence de Médicine Préventive, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Nadjib, Mardiati" sort="Nadjib, Mardiati" uniqKey="Nadjib M" first="Mardiati" last="Nadjib">Mardiati Nadjib</name><affiliation><nlm:aff id="aff17">Faculty of Public Health, University of Indonesia, Jakarta, Indonesia</nlm:aff></affiliation></author><author><name sortKey="Carosone Ink, Phyllis J" sort="Carosone Ink, Phyllis J" uniqKey="Carosone Ink P" first="Phyllis J." last="Carosone Ink">Phyllis J. Carosone Ink</name><affiliation><nlm:aff id="aff18">Department of Pediatrics, Section of Infectious Diseases, University of Colorado Denver School of Medicine, Denver, CO, USA</nlm:aff></affiliation></author><author><name sortKey="Sim Es, Eric Af" sort="Sim Es, Eric Af" uniqKey="Sim Es E" first="Eric Af" last="Sim Es">Eric Af Sim Es</name><affiliation><nlm:aff id="aff18">Department of Pediatrics, Section of Infectious Diseases, University of Colorado Denver School of Medicine, Denver, CO, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff19">Center for Global Health and Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA</nlm:aff></affiliation></author><author><name sortKey="Child, Jason A" sort="Child, Jason A" uniqKey="Child J" first="Jason A" last="Child">Jason A. Child</name><affiliation><nlm:aff id="aff20">Pharmacy Department, Children's Hospital Colorado, Aurora, CO, USA</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Imran" sort="Ahmed, Imran" uniqKey="Ahmed I" first="Imran" last="Ahmed">Imran Ahmed</name><affiliation><nlm:aff id="aff21">Center of Excellence in Women and Child Health, the Aga Khan University, Karachi, Pakistan</nlm:aff></affiliation></author><author><name sortKey="Bhutta, Zulfiqar A" sort="Bhutta, Zulfiqar A" uniqKey="Bhutta Z" first="Zulfiqar A" last="Bhutta">Zulfiqar A. Bhutta</name><affiliation><nlm:aff id="aff21">Center of Excellence in Women and Child Health, the Aga Khan University, Karachi, Pakistan</nlm:aff></affiliation></author><author><name sortKey="Soofi, Sajid B" sort="Soofi, Sajid B" uniqKey="Soofi S" first="Sajid B" last="Soofi">Sajid B. Soofi</name><affiliation><nlm:aff id="aff22">Department of Paediatrics & Child Health, The Aga Khan University, Karachi, Pakistan</nlm:aff></affiliation></author><author><name sortKey="Khan, Rumana J" sort="Khan, Rumana J" uniqKey="Khan R" first="Rumana J" last="Khan">Rumana J. Khan</name><affiliation><nlm:aff id="aff23">James P Grant School of Public Health, BRAC University, Dhaka, Bangladesh</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="aff1">Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Nair, Harish" sort="Nair, Harish" uniqKey="Nair H" first="Harish" last="Nair">Harish Nair</name><affiliation><nlm:aff id="aff1">Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff24">Public Health Foundation of India, New Delhi, India</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27231544</idno><idno type="pmc">4871066</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871066</idno><idno type="RBID">PMC:4871066</idno><idno type="doi">10.7189/jogh.06.010408</idno><date when="????">????</date><idno type="wicri:Area/Pmc/Corpus">000555</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000555</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cost of management of severe pneumonia in young children: systematic analysis</title><author><name sortKey="Zhang, Shanshan" sort="Zhang, Shanshan" uniqKey="Zhang S" first="Shanshan" last="Zhang">Shanshan Zhang</name><affiliation><nlm:aff id="aff1">Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Preventive Dentistry, Peking University, School and Hospital of Stomatology, Beijing, PR China</nlm:aff></affiliation></author><author><name sortKey="Sammon, Peter M" sort="Sammon, Peter M" uniqKey="Sammon P" first="Peter M." last="Sammon">Peter M. Sammon</name><affiliation><nlm:aff id="aff1">Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="King, Isobel" sort="King, Isobel" uniqKey="King I" first="Isobel" last="King">Isobel King</name><affiliation><nlm:aff id="aff1">Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">NHS Grampian, UK</nlm:aff></affiliation></author><author><name sortKey="Andrade, Ana Lucia" sort="Andrade, Ana Lucia" uniqKey="Andrade A" first="Ana Lucia" last="Andrade">Ana Lucia Andrade</name><affiliation><nlm:aff id="aff4">Department of Community Health, Federal University of Goias, Brazil</nlm:aff></affiliation></author><author><name sortKey="Toscano, Cristiana M" sort="Toscano, Cristiana M" uniqKey="Toscano C" first="Cristiana M." last="Toscano">Cristiana M. Toscano</name><affiliation><nlm:aff id="aff4">Department of Community Health, Federal University of Goias, Brazil</nlm:aff></affiliation></author><author><name sortKey="Araujo, Sheila N" sort="Araujo, Sheila N" uniqKey="Araujo S" first="Sheila N" last="Araujo">Sheila N. Araujo</name><affiliation><nlm:aff id="aff4">Department of Community Health, Federal University of Goias, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">State University of Maranhăo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Sinha, Anushua" sort="Sinha, Anushua" uniqKey="Sinha A" first="Anushua" last="Sinha">Anushua Sinha</name><affiliation><nlm:aff id="aff6">New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey USA</nlm:aff></affiliation></author><author><name sortKey="Madhi, Shabir A" sort="Madhi, Shabir A" uniqKey="Madhi S" first="Shabir A." last="Madhi">Shabir A. Madhi</name><affiliation><nlm:aff id="aff7">Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="aff8">Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation></author><author><name sortKey="Khandaker, Gulam" sort="Khandaker, Gulam" uniqKey="Khandaker G" first="Gulam" last="Khandaker">Gulam Khandaker</name><affiliation><nlm:aff id="aff9">National Centre for Immunisation Research and Surveillance, The Children's Hospital at Westmead, NSW, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Sydney School of Public Health, Faculty of Medicine, The University of Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Yin, Jiehui Kevin" sort="Yin, Jiehui Kevin" uniqKey="Yin J" first="Jiehui Kevin" last="Yin">Jiehui Kevin Yin</name><affiliation><nlm:aff id="aff9">National Centre for Immunisation Research and Surveillance, The Children's Hospital at Westmead, NSW, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Sydney School of Public Health, Faculty of Medicine, The University of Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Booy, Robert" sort="Booy, Robert" uniqKey="Booy R" first="Robert" last="Booy">Robert Booy</name><affiliation><nlm:aff id="aff9">National Centre for Immunisation Research and Surveillance, The Children's Hospital at Westmead, NSW, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Sydney School of Public Health, Faculty of Medicine, The University of Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Huda, Tanvir M" sort="Huda, Tanvir M" uniqKey="Huda T" first="Tanvir M" last="Huda">Tanvir M. Huda</name><affiliation><nlm:aff id="aff11">Centre for Child and Adolescent Health, icddr,b, Dhaka, Bangladesh</nlm:aff></affiliation><affiliation><nlm:aff id="aff12">School of Public Health, Sydney Medical School, University of Sydney, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Rahman, Qazi S" sort="Rahman, Qazi S" uniqKey="Rahman Q" first="Qazi S" last="Rahman">Qazi S. Rahman</name><affiliation><nlm:aff id="aff11">Centre for Child and Adolescent Health, icddr,b, Dhaka, Bangladesh</nlm:aff></affiliation></author><author><name sortKey="El Arifeen, Shams" sort="El Arifeen, Shams" uniqKey="El Arifeen S" first="Shams" last="El Arifeen">Shams El Arifeen</name><affiliation><nlm:aff id="aff11">Centre for Child and Adolescent Health, icddr,b, Dhaka, Bangladesh</nlm:aff></affiliation></author><author><name sortKey="Gentile, Angela" sort="Gentile, Angela" uniqKey="Gentile A" first="Angela" last="Gentile">Angela Gentile</name><affiliation><nlm:aff id="aff13">Epidemiology Department, Ricardo Gutierrez Children Hospital, University of Buenos Aires, Argentina</nlm:aff></affiliation></author><author><name sortKey="Giglio, Norberto" sort="Giglio, Norberto" uniqKey="Giglio N" first="Norberto" last="Giglio">Norberto Giglio</name><affiliation><nlm:aff id="aff13">Epidemiology Department, Ricardo Gutierrez Children Hospital, University of Buenos Aires, Argentina</nlm:aff></affiliation></author><author><name sortKey="Bhuiyan, Mejbah U" sort="Bhuiyan, Mejbah U" uniqKey="Bhuiyan M" first="Mejbah U." last="Bhuiyan">Mejbah U. Bhuiyan</name><affiliation><nlm:aff id="aff14">Centre for Communicable Diseases, icddr,b, Dhaka, Bangladesh</nlm:aff></affiliation></author><author><name sortKey="Sturm Amirez, Katharine" sort="Sturm Amirez, Katharine" uniqKey="Sturm Amirez K" first="Katharine" last="Sturm Amirez">Katharine Sturm Amirez</name><affiliation><nlm:aff id="aff14">Centre for Communicable Diseases, icddr,b, Dhaka, Bangladesh</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Gessner, Bradford D" sort="Gessner, Bradford D" uniqKey="Gessner B" first="Bradford D." last="Gessner">Bradford D. Gessner</name><affiliation><nlm:aff id="aff16">Agence de Médicine Préventive, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Nadjib, Mardiati" sort="Nadjib, Mardiati" uniqKey="Nadjib M" first="Mardiati" last="Nadjib">Mardiati Nadjib</name><affiliation><nlm:aff id="aff17">Faculty of Public Health, University of Indonesia, Jakarta, Indonesia</nlm:aff></affiliation></author><author><name sortKey="Carosone Ink, Phyllis J" sort="Carosone Ink, Phyllis J" uniqKey="Carosone Ink P" first="Phyllis J." last="Carosone Ink">Phyllis J. Carosone Ink</name><affiliation><nlm:aff id="aff18">Department of Pediatrics, Section of Infectious Diseases, University of Colorado Denver School of Medicine, Denver, CO, USA</nlm:aff></affiliation></author><author><name sortKey="Sim Es, Eric Af" sort="Sim Es, Eric Af" uniqKey="Sim Es E" first="Eric Af" last="Sim Es">Eric Af Sim Es</name><affiliation><nlm:aff id="aff18">Department of Pediatrics, Section of Infectious Diseases, University of Colorado Denver School of Medicine, Denver, CO, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff19">Center for Global Health and Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA</nlm:aff></affiliation></author><author><name sortKey="Child, Jason A" sort="Child, Jason A" uniqKey="Child J" first="Jason A" last="Child">Jason A. Child</name><affiliation><nlm:aff id="aff20">Pharmacy Department, Children's Hospital Colorado, Aurora, CO, USA</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Imran" sort="Ahmed, Imran" uniqKey="Ahmed I" first="Imran" last="Ahmed">Imran Ahmed</name><affiliation><nlm:aff id="aff21">Center of Excellence in Women and Child Health, the Aga Khan University, Karachi, Pakistan</nlm:aff></affiliation></author><author><name sortKey="Bhutta, Zulfiqar A" sort="Bhutta, Zulfiqar A" uniqKey="Bhutta Z" first="Zulfiqar A" last="Bhutta">Zulfiqar A. Bhutta</name><affiliation><nlm:aff id="aff21">Center of Excellence in Women and Child Health, the Aga Khan University, Karachi, Pakistan</nlm:aff></affiliation></author><author><name sortKey="Soofi, Sajid B" sort="Soofi, Sajid B" uniqKey="Soofi S" first="Sajid B" last="Soofi">Sajid B. Soofi</name><affiliation><nlm:aff id="aff22">Department of Paediatrics & Child Health, The Aga Khan University, Karachi, Pakistan</nlm:aff></affiliation></author><author><name sortKey="Khan, Rumana J" sort="Khan, Rumana J" uniqKey="Khan R" first="Rumana J" last="Khan">Rumana J. Khan</name><affiliation><nlm:aff id="aff23">James P Grant School of Public Health, BRAC University, Dhaka, Bangladesh</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="aff1">Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Nair, Harish" sort="Nair, Harish" uniqKey="Nair H" first="Harish" last="Nair">Harish Nair</name><affiliation><nlm:aff id="aff1">Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff24">Public Health Foundation of India, New Delhi, India</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Global Health</title><idno type="ISSN">2047-2978</idno><idno type="eISSN">2047-2986</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Childhood pneumonia is a major cause of childhood illness and the second leading cause of child death globally. Understanding the costs associated with the management of childhood pneumonia is essential for resource allocation and priority setting for child health.</p></sec><sec><title>Methods</title><p>We conducted a systematic review to identify studies reporting data on the cost of management of pneumonia in children younger than 5 years old. We collected unpublished cost data on non–severe, severe and very severe pneumonia through collaboration with an international working group. We extracted data on cost per episode, duration of hospital stay and unit cost of interventions for the management of pneumonia. The mean (95% confidence interval, CI) and median (interquartile range, IQR) treatment costs were estimated and reported where appropriate.</p></sec><sec><title>Results</title><p>We identified 24 published studies eligible for inclusion and supplemented these with data from 10 unpublished studies. The 34 studies included in the cost analysis contained data on more than 95 000 children with pneumonia from both low– and–middle income countries (LMIC) and high–income countries (HIC) covering all 6 WHO regions. The total cost (per episode) for management of severe pneumonia was US$ 4.3 (95% CI 1.5–8.7), US$ 51.7 (95% CI 17.4–91.0) and US$ 242.7 (95% CI 153.6–341.4)–559.4 (95% CI 268.9–886.3) in community, out–patient facilities and different levels of hospital in–patient settings in LMIC. Direct medical cost for severe pneumonia in hospital inpatient settings was estimated to be 26.6%–115.8% of patients’ monthly household income in LMIC. The mean direct non–medical cost and indirect cost for severe pneumonia management accounted for 0.5–31% of weekly household income. The mean length of stay (LOS) in hospital for children with severe pneumonia was 5.8 (IQR 5.3–6.4) and 7.7 (IQR 5.5–9.9) days in LMIC and HIC respectively for these children.</p></sec><sec><title>Conclusion</title><p>This is the most comprehensive review to date of cost data from studies on the management of childhood pneumonia and these data should be helpful for health services planning and priority setting by national programmes and international agencies.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rudan, I" uniqKey="Rudan I">I Rudan</name></author><author><name sortKey="O Rien, Kl" uniqKey="O Rien K">KL O’Brien</name></author><author><name sortKey="Nair, H" uniqKey="Nair H">H Nair</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author><author><name sortKey="Theodoratou, E" uniqKey="Theodoratou E">E Theodoratou</name></author><author><name sortKey="Qazi, S" uniqKey="Qazi S">S 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Glob Health</journal-id><journal-id journal-id-type="iso-abbrev">J Glob Health</journal-id><journal-id journal-id-type="publisher-id">JGH</journal-id><journal-title-group><journal-title>Journal of Global Health</journal-title></journal-title-group><issn pub-type="ppub">2047-2978</issn><issn pub-type="epub">2047-2986</issn><publisher><publisher-name>Edinburgh University Global Health Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27231544</article-id><article-id pub-id-type="pmc">4871066</article-id><article-id pub-id-type="publisher-id">jogh-06-010408</article-id><article-id pub-id-type="doi">10.7189/jogh.06.010408</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Cost of management of severe pneumonia in young children: systematic analysis</article-title><alt-title alt-title-type="running-head">Nair et al. 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contrib-type="author"><name><surname>Carosone–Link</surname><given-names>Phyllis J.</given-names></name><xref ref-type="aff" rid="aff18"><sup>18</sup></xref></contrib><contrib contrib-type="author"><name><surname>Simões</surname><given-names>Eric AF</given-names></name><xref ref-type="aff" rid="aff18"><sup>18</sup></xref><xref ref-type="aff" rid="aff19"><sup>19</sup></xref></contrib><contrib contrib-type="author"><name><surname>Child</surname><given-names>Jason A</given-names></name><xref ref-type="aff" rid="aff20"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ahmed</surname><given-names>Imran</given-names></name><xref ref-type="aff" rid="aff21"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bhutta</surname><given-names>Zulfiqar A</given-names></name><xref ref-type="aff" rid="aff21"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Soofi</surname><given-names>Sajid B</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Khan</surname><given-names>Rumana J</given-names></name><xref ref-type="aff" rid="aff23"><sup>23</sup></xref></contrib><contrib contrib-type="author"><name><surname>Campbell</surname><given-names>Harry</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nair</surname><given-names>Harish</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><aff id="aff1"><label>1</label>Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK</aff><aff id="aff2"><label>2</label>Department of Preventive Dentistry, Peking University, School and Hospital of Stomatology, Beijing, PR China</aff><aff id="aff3"><label>3</label>NHS Grampian, UK</aff><aff id="aff4"><label>4</label>Department of Community Health, Federal University of Goias, Brazil</aff><aff id="aff5"><label>5</label>State University of Maranhăo, Brazil</aff><aff id="aff6"><label>6</label>New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey USA</aff><aff id="aff7"><label>7</label>Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa</aff><aff id="aff8"><label>8</label>Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa</aff><aff id="aff9"><label>9</label>National Centre for Immunisation Research and Surveillance, The Children's Hospital at Westmead, NSW, Australia</aff><aff id="aff10"><label>10</label>Sydney School of Public Health, Faculty of Medicine, The University of Sydney, NSW, Australia</aff><aff id="aff11"><label>11</label>Centre for Child and Adolescent Health, icddr,b, Dhaka, Bangladesh</aff><aff id="aff12"><label>12</label>School of Public Health, Sydney Medical School, University of Sydney, Sydney, Australia</aff><aff id="aff13"><label>13</label>Epidemiology Department, Ricardo Gutierrez Children Hospital, University of Buenos Aires, Argentina</aff><aff id="aff14"><label>14</label>Centre for Communicable Diseases, icddr,b, Dhaka, Bangladesh</aff><aff id="aff15"><label>15</label>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA</aff><aff id="aff16"><label>16</label>Agence de Médicine Préventive, Paris, France</aff><aff id="aff17"><label>17</label>Faculty of Public Health, University of Indonesia, Jakarta, Indonesia</aff><aff id="aff18"><label>18</label>Department of Pediatrics, Section of Infectious Diseases, University of Colorado Denver School of Medicine, Denver, CO, USA</aff><aff id="aff19"><label>19</label>Center for Global Health and Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA</aff><aff id="aff20"><label>20</label>Pharmacy Department, Children's Hospital Colorado, Aurora, CO, USA</aff><aff id="aff21"><label>21</label>Center of Excellence in Women and Child Health, the Aga Khan University, Karachi, Pakistan</aff><aff id="aff22"><label>22</label>Department of Paediatrics & Child Health, The Aga Khan University, Karachi, Pakistan</aff><aff id="aff23"><label>23</label>James P Grant School of Public Health, BRAC University, Dhaka, Bangladesh</aff><aff id="aff24"><label>24</label>Public Health Foundation of India, New Delhi, India</aff></contrib-group><author-notes><corresp id="cor1"><bold>Correspondence to:</bold>
Dr Harish Nair
Centre for Global Health Research
Usher Institute of Population Health Sciences and Health Informatics
University of Edinburgh Medical School
Edinburgh EH8 9AG
United Kingdom
<email xlink:href="harish.nair@ed.ac.uk">harish.nair@ed.ac.uk</email></corresp></author-notes><pub-date date-type="pub" publication-format="print"><month>6</month><year>2016</year></pub-date><pub-date date-type="pub" publication-format="electronic"><day>15</day><month>3</month><year>2016</year></pub-date><volume>6</volume><issue>1</issue><elocation-id>010408</elocation-id><permissions><copyright-statement>Copyright © 2016 by the Journal of Global Health. All rights reserved.</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.5/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>Background</title><p>Childhood pneumonia is a major cause of childhood illness and the second leading cause of child death globally. Understanding the costs associated with the management of childhood pneumonia is essential for resource allocation and priority setting for child health.</p></sec><sec><title>Methods</title><p>We conducted a systematic review to identify studies reporting data on the cost of management of pneumonia in children younger than 5 years old. We collected unpublished cost data on non–severe, severe and very severe pneumonia through collaboration with an international working group. We extracted data on cost per episode, duration of hospital stay and unit cost of interventions for the management of pneumonia. The mean (95% confidence interval, CI) and median (interquartile range, IQR) treatment costs were estimated and reported where appropriate.</p></sec><sec><title>Results</title><p>We identified 24 published studies eligible for inclusion and supplemented these with data from 10 unpublished studies. The 34 studies included in the cost analysis contained data on more than 95 000 children with pneumonia from both low– and–middle income countries (LMIC) and high–income countries (HIC) covering all 6 WHO regions. The total cost (per episode) for management of severe pneumonia was US$ 4.3 (95% CI 1.5–8.7), US$ 51.7 (95% CI 17.4–91.0) and US$ 242.7 (95% CI 153.6–341.4)–559.4 (95% CI 268.9–886.3) in community, out–patient facilities and different levels of hospital in–patient settings in LMIC. Direct medical cost for severe pneumonia in hospital inpatient settings was estimated to be 26.6%–115.8% of patients’ monthly household income in LMIC. The mean direct non–medical cost and indirect cost for severe pneumonia management accounted for 0.5–31% of weekly household income. The mean length of stay (LOS) in hospital for children with severe pneumonia was 5.8 (IQR 5.3–6.4) and 7.7 (IQR 5.5–9.9) days in LMIC and HIC respectively for these children.</p></sec><sec><title>Conclusion</title><p>This is the most comprehensive review to date of cost data from studies on the management of childhood pneumonia and these data should be helpful for health services planning and priority setting by national programmes and international agencies.</p></sec></abstract><counts><page-count count="15"></page-count></counts></article-meta></front><body><p>Pneumonia is one of the leading causes of morbidity and mortality in children under–five globally, and accounted for about 935 000 (15%) deaths in 2013 and 120 million new episodes of illness in this age group in 2010 [<xref rid="R1" ref-type="bibr">1</xref>,<xref rid="R2" ref-type="bibr">2</xref>]. Appropriate management of childhood pneumonia can reduce pneumonia–specific mortality by 32–72% [<xref rid="R3" ref-type="bibr">3</xref>–<xref rid="R5" ref-type="bibr">5</xref>] and thus accelerate the progress toward achievement of the Millennium Development Goal 4 (MDG4). Childhood pneumonia places a large economic burden on families and the health care system, especially in resource–constrained low– and middle–income countries (LMIC). Severe ALRI is a substantial burden on health services worldwide and a major cause of hospital referral and admission in young children [<xref rid="R6" ref-type="bibr">6</xref>]. Although several studies in high–income as well as low– and middle–income countries have reported the costs associated with an episode of pneumonia (at the individual patient level), there are no published systematic reviews summarizing the evidence from different health systems and settings globally. Bahia et al reviewed pneumococcal disease costs and productivity loss in Latin America and the Caribbean showed variation in unit costs of pneumococcal pneumonia at outpatient and inpatient levels [<xref rid="R7" ref-type="bibr">7</xref>]. We aimed to conduct a systematic review of published data on the costs associated with management of pneumonia episodes in children younger than 5 years and to identify unpublished data sets from pneumonia research groups globally. Cost estimates based on these data should be useful to develop models for estimating cost of management of pneumonia in community as well as hospital–based settings.</p><sec sec-type="methods"><title>METHODS</title><sec><title>Review of published studies</title><p>We aimed to identify all published studies reporting empirical cost data on the treatment of episodes of pneumonia in children aged below 5 years during a 15–year period (1998–2013). We included studies in children younger than 5 years with pneumonia managed as in–patients or out–patients (using standard treatment per local standard) in secondary and tertiary hospitals, first level facility or in community settings. Data on the cost of a single episode of severe pneumonia from the societal and health care perspectives were collected as the primary study outcome. We developed a review protocol at the beginning of this study and followed the same throughout the process.</p><p>We undertook a systematic literature review with three reviewers (PS, IK, SZ), and hand searched reference list of all included articles. We searched four databases (with online search tools) to offer maximum coverage of the relevant literature: Medline, EMBASE, The Centre for Review and Dissemination Library (incorporating the DARE, NHS EED, and NHS HTA databases); and The Cochrane Library (via the Wiley Online Library) for the period 1 January 1998 to October 31 2013. (for search strategy, see Appendix S1 in <bold>Online Supplementary Document<xref ref-type="supplementary-material" rid="S1">(Online Supplementary Document)</xref></bold>).</p><p>Three review authors (SZ, PS, IK) independently selected potentially relevant studies based on their title and abstract. Any disagreements in study selection or data extraction were resolved after discussion with SZ and HC. The eligible studies were retrieved electronically for full–text review. We included studies that investigated all–cause pneumonia in a non–selective population sample, reported empirical cost data for pneumonia treatment (using any intervention including, but not limited to, antibiotics), and included only children younger than 5 years or reported data separately for this age group. We excluded review articles, vaccine cost–effectiveness trials, and studies considering specially selected cohorts with severe co–morbidity (Appendix S2 in <bold>Online Supplementary Document<xref ref-type="supplementary-material" rid="S1">(Online Supplementary Document)</xref></bold>). We developed and piloted a comprehensive data extraction template. We collected data on cost per episode, cost and unit cost of medication and services, duration of hospital stay and direct medical and non–medical costs. Direct medical cost included costs related to medication, diagnostic tests, medical staff time and hospital stay. Direct non–medical costs included those relating to food, transportation and accommodation charges. Any additional data on indirect costs such as care–givers’ time and earning loss were also recorded, where available. Additionally, we extracted data on study characteristics including country, treatment setting, study type and sample size. We recorded the cost study perspective only if explicitly stated in the text of the article to avoid subjective influence. For those papers that did not explicitly state the perspective used, we noted “–“ for “unstated”.</p><p>We classified countries into high income and low–and–middle income categories based on the classification adopted by the World Bank and according to 2012 Gross National Income (GNI) per capita, calculated using the World Bank Atlas method. The groups are low–income per capita US$ 1035 or less; lower middle–income US$ 1036–US$ 4085; upper middle income US$ 4086–US$ 12 615; and high income US $12 616 or more [<xref rid="R8" ref-type="bibr">8</xref>].</p></sec><sec><title>Quality assessment</title><p>We assessed the quality of the included studies using a 13 point scale based on a modified Drummond checklist [<xref rid="R9" ref-type="bibr">9</xref>] for economic evaluation focusing on the methodological robustness and detail of reporting (Appendix S3 in <bold>Online Supplementary Document<xref ref-type="supplementary-material" rid="S1">(Online Supplementary Document)</xref></bold>). Studies were considered high quality if more than 10 points were addressed, medium quality studies covered 7–9 points and low quality studies addressed less than 6 points. Studies with all quality levels were included in the final analysis.</p></sec><sec><title>Unpublished data collection</title><p>We collected unpublished data from 10 collaborating sites that were part of a Severe ALRI Working Group (SAWG) [<xref rid="R6" ref-type="bibr">6</xref>]. The study population included children under 5 years of age with a clinical diagnosis of pneumonia. We defined pneumonia using the World Health Organization’s (WHO) Integrated Mangement of Childhood Illness (ICMI) definition by three different severity categories: non–severe, severe and very severe pneumonia based on WHO pocket book for hospital care for children 2005 [<xref rid="R10" ref-type="bibr">10</xref>]. We included all interventions for pneumonia management as detailed in the WHO pocket–book (for community/and facility–based management) where data were available.</p><p>We designed a costing spreadsheet with detailed descriptions of case definitions and methods and used this for data collection. Actual cost of medications, supplies, personnel and average laboratory costs were collected. Methods used to gather primary cost data in these studies were recorded in the spreadsheet. Resource utilization data from patient records were also documented, where available, including length of stay in hospital, the quantity of drugs and supplies utilized by each patient, and the use of diagnostic tests and procedures. We also attempted to collect data on out–of–pocket spending (by patients) on transport and food where possible. Indirect cost of caregivers’ time and daily pay rate were also recorded. Primary data collection was conducted using the provided standardized templates and guidelines at individual study site. (Appendix S4 in <bold>Online Supplementary Document<xref ref-type="supplementary-material" rid="S1">(Online Supplementary Document)</xref></bold>).</p><p>We used a bottom–up approach to calculate cost per episode for each level of the intervention (community, first level health facility and hospital). Costs were calculated and presented separately based on severity and service delivery channels: very severe pneumonia at hospital level (defined as pneumonia with central cyanosis, inability to breastfeed or drink, or vomiting everything, convulsions, lethargy or unconsciousness and severe respiratory distress diagnosed by doctor or physicians using WHO IMCI (2005) case definition or pneumonia cases requires critical care); severe pneumonia at hospital level (defined as pneumonia with chest indrawing using WHO IMCI definition or pneumonia need for hospital admission based on physician’s assessment); severe pneumonia at community level (based on assessment by a trained health worker at home/first level facility using WHO IMCI (2005) case definition); and non–severe pneumonia at outpatient level (defined as fast breathing for age in children aged 2 to 59 months). The costing model included direct medical cost, direct non–medical cost and indirect costs. We calculated the cost per episode based on the estimates of the unit cost per contact (eg, unit cost of an antibiotic per day) at each management level multiplied by the resource utilization proportions (eg, 80% of children took amoxicillin for 5 days), plus indirect costs. For the mean total cost of treatment per episode we summed the cost of drugs, diagnostic investigations and hospital stay, as well as transportation and opportunity cost for caregivers’ time. The formula is given in <xref ref-type="fig" rid="F1"><bold>Figure 1</bold></xref>.</p><fig id="F1" fig-type="figure" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Formula for the mean total cost of treatment per episode.</p></caption><graphic xlink:href="jogh-06-010408-F1"></graphic></fig><p>We reported all cost data in 2013 US$ equivalent prices. We first converted all costs to US$ and then adjusted for inflation to 2013 values. Conversions were made using the Penn World Tables 8.0 (<ext-link ext-link-type="uri" xlink:href="http://www.ggdc.net/pwt">http://www.ggdc.net/pwt</ext-link>) and an online inflation–calculating tool (<ext-link ext-link-type="uri" xlink:href="http://usinflation.org/cpi-inflation-calculator">http://usinflation.org/cpi-inflation-calculator</ext-link>) on 20<sup>th</sup> October 2013.</p></sec><sec><title>Statistical analysis</title><p>We have stratified the cost results by country income category: high–income countries (HIC) and low– and middle–income countries (LMIC). As an important input in the costing analysis for in–patient management, length of stay (LOS) in hospital was extracted for severe hospitalized cases. Cost per episode, cost by component (direct medical, direct non–medical and indirect costs), and percentage of total cost per episode in each component were summarized. Cost per episode was synthesized by severity of diseases in each strata. The mean with 95% CI of the treatment costs and the median with interquartile range (IQR) of LOS were estimated and reported where appropriate. The 95% CIs were calculated based on 5000 bootstrap samples. Mean and median values were compared using appropriate statistical tests.</p><p>Direct medical cost in studies reported from household perspective were compared with monthly household income in respective countries to evaluate the burden on families. Monthly household incomes were derived from Gallup World Poll using annual median household income divided by 12 months [<xref rid="R11" ref-type="bibr">11</xref>]. These income results were based on Gallup data gathered between 2006 and 2012 in 131 populations. In two countries which annual household income data was missing, we used GNI per capita from World Bank database times the mean number of people per household instead. The percentages of direct non–medical costs and indirect cost per episode of weekly household income were also assessed to show the economic impact of pneumonia management for families when direct medical cost was not considered.</p><p>We conducted all data analyses using SPSS v.19 (IBM, New York City, NY, USA) noting that included studies showed marked heterogeneity of population, methodology, treatment procedure reporting categories and perspectives.</p></sec></sec><sec sec-type="results"><title>RESULTS</title><sec><title>Search results</title><p>We identified 789 studies through database searching, of which 60 articles were eligible for full text review on the basis of title and abstract assessment (<xref ref-type="fig" rid="F2"><bold>Figure 2</bold></xref>). Subsequently, only 24 papers were identified to be eligible for data extraction and analysis. The key reasons for exclusions included: no data for children below 5 years or no cost data on pneumonia management were reported. For unpublished studies, we contacted 16 sites, 10 of which had data that met our eligibility criteria and contributed to the analysis. The unpublished cost data were for the period January 2001 to August 2012. Six of these sites provided cost data using a template and guidelines designed for this project while the remainder provided unpublished data in their own formats.</p><fig id="F2" fig-type="figure" orientation="portrait" position="float"><label>Figure 2</label><caption><p>PRISMA flow diagram for severe pneumonia cost systematic review.</p></caption><graphic xlink:href="jogh-06-010408-F2"></graphic></fig></sec><sec><title>Characteristics of published and unpublished data</title><p>We identified 24 studies from the literature review and collected additional 10 data sets of unpublished studies totalling 34 studies from 21 countries across the 6 WHO regions (<xref ref-type="fig" rid="F1"><bold>Table 1</bold></xref>). Over 60% of the studies (21 out of 34) were conducted in the South East Asia and Africa Regions. The included studies reported data from a variety of treatment settings: community, out–patient and in–patient care settings in primary, secondary and tertiary hospitals, and at city, district, provincial and national levels. Twenty–seven of the 34 studies were stand–alone primary cost analysis and/or cost–of–illness studies. The remaining 7 studies were designed to collect cost data alongside clinical trials or epidemiological studies.</p><p>The included studies reported cost data on a total of 97 062 children treated at facility or community levels, with a median sample size of 378 (IQR 117–741) across all studies. The age of the participants was reported in 12 studies and the median age was 12.3 months (IQR 8.20–33.20). The perspective of costing was explicitly stated in 30 of 34 studies. Of these, the most common perspectives were societal (16 out of 33, 1 study did not specify perspective), health care (11 out of 33) and household (5 out of 33). In most studies, the sources of pneumonia case definition were physician’s diagnosis according to WHO IMCI definition (29 out of 34), culture–proved pneumonia was used for case definition in 1 study, self–reported condition according to WHO IMCI definition was adopted in one study, and two studies used health workers’ diagnosis. A number of different sources were used for gathering cost data, the most common being through hospital records and costing interviews/questionnaires. Interviews and questionnaires were commonly used in studies with a household perspective to collect data on indirect costs. Other sources included a national database of costs, insurance databases, surveillance data and pharmaceutical databases. The WHO CHOICE database, expert opinion and data from pilot studies were also used to collect data on the unit cost of pneumonia treatment.</p><p>The average quality score of 24 published studies was 8.21 out of 13 on scale based on modified Drummond checklist (range 3–12) (Appendix S5 in <bold>Online Supplementary Document<xref ref-type="supplementary-material" rid="S1">(Online Supplementary Document)</xref></bold>). The majority of the studies failed to consider discounting and did not perform sensitivity analyses. There were 6 studies considered high quality, 14 studies were medium quality, and 4 low quality studies. All studies were included into the final analysis.</p></sec><sec><title>Cost of management per episode of pneumonia</title><p>Cost results stratified by income category are presented in <xref ref-type="table" rid="T2"><bold>Table 2</bold></xref>, <xref ref-type="table" rid="T3"><bold>Table 3</bold></xref> and <xref ref-type="fig" rid="F3"><bold>Figure 3</bold></xref>. In HICs, the mean cost of treatment for an episode of severe pneumonia at the hospital out–patient level was US$ 251.1 in Germany [<xref rid="R16" ref-type="bibr">16</xref>]. An Australian study [<xref rid="R14" ref-type="bibr">14</xref>] reported similar cost of US$ 254.9 for community management of severe pneumonia. Average costs of facility based case management for young children admitted in primary/sary and tertiary hospitals were US$ 2803.5 (95% CI IQR 2000.6–3683.3), and US$ 7037.2 (95% CI 4028.6–11 311.0) respectively, which was 11–28 fold higher than in those managed as out–patients. The total cost per episode for the management of non–severe pneumonia at out–patient level was also reported for three countries: US$55.8 in Uruguay [<xref rid="R12" ref-type="bibr">12</xref>], US$ 272.7 in Chile [<xref rid="R12" ref-type="bibr">12</xref>] and US$ 334.6 in the United States [<xref rid="R36" ref-type="bibr">36</xref>]. The cost for very severe pneumonia managed in general pediatric wards followed by intensive care unit (ICU) care was reported to be US$9151.3 in a tertiary hospital in Spain [<xref rid="R17" ref-type="bibr">17</xref>] and US$ 120 576.3 in the United States, which is nearly 2–17 fold of the cost for severe pneumonia management in hospital settings in HICs. The majority of studies from HIC took only direct medical costs into consideration. Only two studies included direct non–medical costs and indirect costs [<xref rid="R16" ref-type="bibr">16</xref>]. The mean proportion of the total cost for direct medical, direct non–medical and indirect costs were 41.5%, 19.5% and 38.5% respectively.</p><table-wrap id="T2" orientation="portrait" position="float"><label>Table 2</label><caption><p>Cost per episode for childhood pneumonia management in high–income countries</p></caption><table frame="hsides" rules="groups"><col width="73" span="1"></col><col width="42" span="1"></col><col width="85" span="1"></col><col width="56" span="1"></col><col width="35" span="1"></col><col width="56" span="1"></col><col width="56" span="1"></col><col width="49" span="1"></col><col width="56" span="1"></col><col width="49" span="1"></col><col width="49" span="1"></col><col width="35" span="1"></col><thead><tr><th rowspan="2" valign="top" align="left" scope="col" colspan="1">Severity<hr></hr></th><th rowspan="2" valign="top" align="left" scope="col" colspan="1">WHO region<hr></hr></th><th rowspan="2" valign="top" align="left" scope="col" colspan="1">Country, publication year<hr></hr></th><th rowspan="2" valign="top" align="left" scope="col" colspan="1">Perspective<hr></hr></th><th rowspan="2" valign="top" align="left" scope="col" colspan="1">Sample size<hr></hr></th><th colspan="4" valign="top" align="left" scope="colgroup" rowspan="1">Cost per episode (2013 US$)</th><th colspan="3" valign="top" align="left" scope="colgroup" rowspan="1">Cost component, % of total cost per episode</th></tr></thead><tbody><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><bold>Tertiary/teaching hospital in–patient care</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><bold>Secondary/primary hospital in–patient care</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><bold>Out–patient care</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><bold>Community care</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><bold>Direct medical</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><bold>Direct non–medical</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><bold>Indirect</bold><hr></hr></td></tr><tr><td rowspan="3" valign="top" align="left" scope="row" colspan="1"><bold>Non–severe pneumonia</bold><hr></hr></td><td rowspan="3" valign="top" align="left" colspan="1">AMR<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">US, 2012*<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">940<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">334.6<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Chile, 2007 [<xref rid="R12" ref-type="bibr">12</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">366<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">272.7<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Uruguay, 2007 [<xref rid="R12" ref-type="bibr">12</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">366<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">55.8<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td colspan="5" valign="top" align="left" scope="row" rowspan="1"><bold>Non–severe pneumonia mean cost (95% CI)</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td colspan="3" valign="top" align="left" rowspan="1"><bold>221.0 (55.8–334.6)</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td rowspan="5" valign="top" align="left" scope="row" colspan="1"><bold>Severe pneumonia by WHO IMCI Definition</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">AMR<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Chile, 2007 [<xref rid="R12" ref-type="bibr">12</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">366<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">4316.7<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">Uruguay, 2007 [<xref rid="R12" ref-type="bibr">12</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">366<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">1421.6<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">US, 2012*<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">940<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">15 029.2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">EUR<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">North Ireland, 1999 [<xref rid="R13" ref-type="bibr">13</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">NA<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">45<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">5733.8, 2716.8<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">WPR<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Australia, 2011*<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">NA<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">6,259.1<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">93.1<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">6.9<hr></hr></td></tr><tr><td rowspan="4" valign="top" align="left" scope="row" colspan="1"><bold>Hospitalised pneumonia</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">WPR</td><td valign="top" align="left" rowspan="1" colspan="1">Australia, 2008 [<xref rid="R14" ref-type="bibr">14</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">528<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">2813.1<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">254.9<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Australia, 2008 [<xref rid="R15" ref-type="bibr">15</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">1348<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">2307.8<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">EUR</td><td valign="top" align="left" rowspan="1" colspan="1">Germany, 2005 [<xref rid="R16" ref-type="bibr">16</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">402<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">3158.6<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">251.1<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">41.5<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">19.5<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">38.5<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Spain, 2013 [<xref rid="R17" ref-type="bibr">17</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">101<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">5447.3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td colspan="5" valign="top" align="left" scope="row" rowspan="1"><bold>Severe pneumonia mean cost (95% CI)</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><bold>7037.2 (40 286–11 311.0)</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><bold>2803.5 (2000.6–3683.3)</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><bold>251.1</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><bold>254.9</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Very severe pneumonia by IMCI</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">AMR<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">US, 2012*<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">940<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">120 576.2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Very severe pneumonia require critical care</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">AMR<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Spain, 2013 [<xref rid="R17" ref-type="bibr">17</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">101<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">9151.3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td colspan="5" valign="top" align="left" scope="row" rowspan="1"><bold>Very severe pneumonia mean cost (95% CI)</bold></td><td colspan="3" valign="top" align="left" rowspan="1"><bold>64 863.8 (9151.3–120 576.3)</bold></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><p>NA – Information not available, EUR – Europe Region, AMR – The Americas Region, WPR – Western Pacific Region, CI – confidence interval, IMCI – Integrated Management of Childhood Illness</p><p>*Unpublished data.</p></table-wrap-foot></table-wrap><table-wrap id="T3" orientation="portrait" position="float"><label>Table 3</label><caption><p>Cost per episode for childhood pneumonia management in low– and middle–income countries</p></caption><table frame="hsides" rules="groups"><col width="73" span="1"></col><col width="42" span="1"></col><col width="85" span="1"></col><col width="56" span="1"></col><col width="35" span="1"></col><col width="56" span="1"></col><col width="56" span="1"></col><col width="49" span="1"></col><col width="56" span="1"></col><col width="49" span="1"></col><col width="49" span="1"></col><col width="35" span="1"></col><thead><tr><th rowspan="2" valign="top" align="center" scope="col" colspan="1">Severity<hr></hr></th><th rowspan="2" valign="top" align="center" scope="col" colspan="1">WHO region<hr></hr></th><th rowspan="2" valign="top" align="center" scope="col" colspan="1">Country, publication year<hr></hr></th><th rowspan="2" valign="top" align="center" scope="col" colspan="1">Perspective<hr></hr></th><th rowspan="2" valign="top" align="center" scope="col" colspan="1">Sample size<hr></hr></th><th colspan="4" valign="top" align="center" scope="colgroup" rowspan="1">Cost per episode (2013 US$)</th><th colspan="3" valign="top" align="center" scope="colgroup" rowspan="1">Cost component, % of total cost per episode</th></tr></thead><tbody><tr><td valign="top" colspan="1" align="center" scope="row" rowspan="1"><bold>Tertiary/teaching hospital in–patient care</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Secondary/primary hospital in–patient care</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Out–patient care</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Community care</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Direct medical</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Direct non–medical</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Indirect</bold><hr></hr></td></tr><tr><td rowspan="7" valign="top" align="left" scope="row" colspan="1"><bold>Non–severe pneumonia</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">SEAR</td><td valign="top" align="center" rowspan="1" colspan="1">Viet Nam, 2010 [<xref rid="R18" ref-type="bibr">18</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">788<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">28.6<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1">Pakistan, 2008 [<xref rid="R19" ref-type="bibr">19</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">141<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">29.4<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1">Pakistan, 2006 [<xref rid="R20" ref-type="bibr">20</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">502<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">94.1–17.8<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Bangladesh, 2012*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">340<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">5.7<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="center" scope="row" rowspan="1">AFR<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Guinea, 1998 [<xref rid="R21" ref-type="bibr">21</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">NA<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">73 650<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">3.2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">South Africa, 2012 [<xref rid="R22" ref-type="bibr">22</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal/health care<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">745<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">263.1<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="center" scope="row" rowspan="1">AMR<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Brazil, 2007 [<xref rid="R12" ref-type="bibr">12</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">366<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">93.0<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td colspan="5" valign="top" align="left" scope="row" rowspan="1"><bold>Non–severe pneumonia mean cost (95% CI)</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td colspan="3" valign="top" align="center" rowspan="1"><bold>66.9 (21.7–129.7)</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td rowspan="16" valign="top" align="left" scope="row" colspan="1"><bold>Severe pneumonia by WHO IMCI Definition</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">SEAR</td><td valign="top" align="center" rowspan="1" colspan="1">Pakistan, 2010*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">NA<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">8.7<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1">Pakistan, 2012 [<xref rid="R23" ref-type="bibr">23</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Household<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">423<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">7.9<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1.5<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">89.1<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1.3<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">9.6<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1">Bangladesh, 2012*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">340<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">5.7<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1">Bangladesh, 2010 [<xref rid="R24" ref-type="bibr">24</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">360<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">193.6<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">124.0<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Y<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Y<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1">Viet Nam, 2010 [<xref rid="R18" ref-type="bibr">18</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">788<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">39.5<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Y<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Y<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Y<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1">Pakistan, 2008 [<xref rid="R19" ref-type="bibr">19</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">141<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">186.0<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">64.1<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">35.9<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1">Pakistan, 2003 [<xref rid="R25" ref-type="bibr">25</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">NA<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">126<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">20.3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1">Bangladesh, 2005*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Household<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">114<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">80.6†<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">62.6#<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">70.9†<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">29.1†<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1">Bangladesh, 2010 [<xref rid="R26" ref-type="bibr">26</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Household<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">90<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">124.2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">67.6<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">32.4<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Indonesia, 2001*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">NA<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">135.2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">75<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">25<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="center" scope="row" rowspan="1">AFR<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Guinea, 1998 [<xref rid="R21" ref-type="bibr">21</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">NA<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">73650<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">110.6<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">69<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">30<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">South Africa, 2001*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">509<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">480.9§<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">110.0<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="center" scope="row" rowspan="1">AMR<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Brazil, 2007 [<xref rid="R12" ref-type="bibr">12</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">366<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">461.0<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Brazil, 2011*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">79<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1474.1†,‡<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">594.5#<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">94†<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1†<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">5†<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Colombia, 2013 [<xref rid="R27" ref-type="bibr">27</xref>]*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1545<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">517.6<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Argentina, 2012*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">NA<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1648.0<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td rowspan="11" valign="top" align="center" scope="row" colspan="1"><bold>Hospitalised pneumonia</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">SEAR<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Viet Nam, 2001 [<xref rid="R28" ref-type="bibr">28</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Household<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">94<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">2.7<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">56–88<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Y<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Pakistan, 2006 [<xref rid="R20" ref-type="bibr">20</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">502<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">310.8<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">127.6<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">45.3<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">55<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">India, 2009 [<xref rid="R29" ref-type="bibr">29</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare/household<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">56<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">145.7<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">44.7<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">45.7<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">5.3<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">47.4<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">India, 2002 [<xref rid="R30" ref-type="bibr">30</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">52<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">23.9<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="center" scope="row" rowspan="1">AFR<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Zambia, 2009 [<xref rid="R31" ref-type="bibr">31</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">9146<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">249.7<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">55.7<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Kenya, 2009 [<xref rid="R32" ref-type="bibr">32</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">205<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">236.8<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">162.1, 89.5<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">86<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">14<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Y<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">South Africa, 2011 [<xref rid="R33" ref-type="bibr">33</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">509<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">491.4†, 1553.2‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">South Africa, 2012 [<xref rid="R22" ref-type="bibr">22</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal/health care<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">745<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1223.1<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">98<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">2<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">0.2<hr></hr></td></tr><tr><td valign="top" colspan="1" align="center" scope="row" rowspan="1">WPR<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Fiji, 2012 [<xref rid="R34" ref-type="bibr">34</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal/household<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">390<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">25.7, 15.6<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">61.9<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">33.2<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">4.9<hr></hr></td></tr><tr><td valign="top" colspan="1" align="center" scope="row" rowspan="1">AMR<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Colombia, 2013 [<xref rid="R27" ref-type="bibr">27</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1545<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">304.4<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">76.2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="center" scope="row" rowspan="1">EMR<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Jordan, 2010 [<xref rid="R35" ref-type="bibr">35</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">NA<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">728<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">563.4<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">100<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td colspan="5" valign="top" align="left" scope="row" rowspan="1"><bold>Severe pneumonia mean cost (95% CI)</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>559.4 (268.9–886.3)</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>242.7 (153.6–341.4)</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>51.7 (17.4–91.0)</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>4.3 (1.5–8.7)</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td rowspan="3" valign="top" align="left" scope="row" colspan="1"><bold>Very severe pneumonia by IMCI</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">SEAR<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Bangladesh, 2012*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">340<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">15.7<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Viet Nam, 2010 [<xref rid="R18" ref-type="bibr">18</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">788<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">61.2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Pakistan, 2008 [<xref rid="R19" ref-type="bibr">19</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">141<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">81.3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td rowspan="3" valign="top" align="left" scope="row" colspan="1"><bold>Very severe pneumonia require critical care</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">AFR<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">South Africa, 2011 [<xref rid="R33" ref-type="bibr">33</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">NA<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">3014<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">849.0†
14795.4‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">South Africa, 2012 [<xref rid="R22" ref-type="bibr">22</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Societal/health care<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">745<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6696.2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" colspan="1" align="center" scope="row" rowspan="1">AMR<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Colombia [<xref rid="R27" ref-type="bibr">27</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1545<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">3643.4<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td colspan="5" valign="top" align="left" scope="row" rowspan="1"><bold>Very severe pneumonia mean cost (95% CI)</bold></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>6496.0 (2246.2–12 007.4)</bold></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>71.3 (61.2–81.3)</bold></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>15.7 (15.7–15.7)</bold></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><p>NA – information not available, Y – authors considered the cost component, but the proportion was unknown, EUR – Europe Region, AMR – The Americas Region, WPR – Western Pacific Region, SEAR – South East Asia, AFR – The Africa Region, EMR – Eastern Mediterranean Region</p><p>*Unpublished data.</p><p>†Public health care.</p><p>‡Private health care.</p><p>§Pediatric ward.</p><p>#Supplementary health system.</p></table-wrap-foot></table-wrap><fig id="F3" fig-type="figure" orientation="portrait" position="float"><label>Figure 3</label><caption><p>Range of cost per episode for pneumonia management (2013 US$).</p></caption><graphic xlink:href="jogh-06-010408-F3"></graphic></fig><p>In LMICs, the cost of case management for severe pneumonia was reported across all treatment settings. The community management cost was only reported in studies conducted in South–East Asia region, with a mean cost of US$ 4.3 (95% CI 1.5–8.7) per episode. Out–patient care mean costs were US$ 51.7 (95% CI 17.4–91.0) per case. Costs for in–patient care varied by regions, level of hospitals (primary/sary/tertiary), and levels of care offered at a facility: the mean cost for primary/sary hospital care was 242.7 (95% CI 153.6–341.4) and for tertiary/teaching hospital was 559.4 (95% CI 268.9–886.3). Two groups–severe pneumonia by WHO IMCI definition and hospitalized pneumonia by physician’s diagnosis–showed similar costs in all levels of care. The in–patient care costs were 4–11 fold greater than that for out–patient care in the LMICs strata, which in turn was significantly higher than that for community management.</p><p>The costs for management of non–severe pneumonia managed at outpatient level were US$ 66.9 (95% CI 21.7–129.7), which was slightly higher than for severe cases at outpatient level. This is because the hospital short stay for non–severe pneumonia in South Africa [<xref rid="R22" ref-type="bibr">22</xref>] was relatively high at US$ 263.1 per episode. The mean cost for very severe cases was US$ 6496.0 (2246.2–12 007.4), which is nearly 10-fold of severe case management cost.</p><p>There were 6 studies reporting cost from household perspective, mainly from LMICs in South East Asia Region. Direct medical cost for severe pneumonia in hospital inpatient settings were 26.6%–115.8% of the monthly household income, thus demonstrating that severe pneumonia management in hospital placed a significant financial burden on families. On the other hand, outpatient and community management of severe pneumonia accounted for only 0.4%–4.1% of family’s monthly income indicating decreased burden in these settings. (<xref ref-type="table" rid="T4"><bold>Table 4</bold></xref>).</p><table-wrap id="T4" orientation="portrait" position="float"><label>Table 4</label><caption><p>Direct medical cost for severe pneumonia management in low– and middle–income countries reported from household perspective</p></caption><table frame="hsides" rules="groups"><col width="85" span="1"></col><col width="92" span="1"></col><col width="82" span="1"></col><col width="77" span="1"></col><col width="93" span="1"></col><col width="75" span="1"></col><col width="1" span="1"></col><thead><tr><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Country, publication year</th><th colspan="4" valign="top" align="center" scope="colgroup" rowspan="1">Direct medical cost (2013 US$; % of direct medical cost to monthly household income)</th><th colspan="2" valign="top" align="center" scope="colgroup" rowspan="1">Monthly household income (2013 $US)<bold>*</bold></th></tr></thead><tbody><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Tertiary/teaching Hospital in–patient care</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Secondary/primary hospital in–patient care</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Out–patient care</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Community ambulatory care</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Bangladesh, 2010 [</bold><xref rid="R26" ref-type="bibr">26</xref><bold>]</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">124.2 (52.9%)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>–</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">234.9<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Bangladesh, 2005</bold>†<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">80.6<sup>‡</sup> (34.3%)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">62.6<sup>§</sup> (26.6%)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>–</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">234.9<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>India, 2009 [</bold><xref rid="R30" ref-type="bibr">30</xref><bold>]</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">305.8 (115.8%)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">135.1 (64.7%)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>–</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">264.0<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Pakistan, 2012 [</bold><xref rid="R23" ref-type="bibr">23</xref><bold>]</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">7.9 (2.3%)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1.5 (0.4%)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">338.3<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Viet Nam, 2001 [</bold><xref rid="R28" ref-type="bibr">28</xref><bold>]</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">2.7 (0.7%)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">398.6<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Fiji, 2012 [</bold><xref rid="R34" ref-type="bibr">34</xref><bold>]</bold></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>–</bold></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>–</bold></td><td valign="top" align="center" rowspan="1" colspan="1">25.7 (4.1%)/15.6 (2.5%)</td><td valign="top" align="center" rowspan="1" colspan="1"><bold>–</bold></td><td valign="top" align="center" rowspan="1" colspan="1">632.5‡</td></tr></tbody></table><table-wrap-foot><p>*Monthly household income (2013 US$) were derived from Gallup World Poll annual median household income, equals annual median household income divided by 12. These results were based on Gallup data gathered between 2006 and 2012 in 131 population. Source: <ext-link ext-link-type="uri" xlink:href="http://www.gallup.com/poll/166211/worldwide-median-household-income-000.aspx">http://www.gallup.com/poll/166211/worldwide-median-household-income-000.aspx</ext-link>.</p><p>†Numbers used GNI per capita based on purchasing power parity (PPP) due to lack of monthly household income data. Source: <ext-link ext-link-type="uri" xlink:href="http://data.worldbank.org/indicator/NY.GNP.PCAP.PP.CD/countries">http://data.worldbank.org/indicator/NY.GNP.PCAP.PP.CD/countries</ext-link>.</p><p>‡Public health care.</p><p>§Supplementary health system.</p></table-wrap-foot></table-wrap><p>Of the papers reporting cost component of severe pneumonia management, direct medical cost was reported across all studies and accounted for 45%–100% of the total cost. The mean direct non–medical cost and indirect cost were US$ 22.0 (11.8–32.7) and US$ 27.0 (4.0–54.3) respectively, which account for 0.5%–31.0% of weekly household income (<xref ref-type="table" rid="T5"><bold>Table 5</bold></xref>).</p><table-wrap id="T5" orientation="portrait" position="float"><label>Table 5</label><caption><p>Direct non–medical cost and indirect cost per episode for severe pneumonia management in low– and middle–income countries</p></caption><table frame="hsides" rules="groups"><col width="92" span="1"></col><col width="60" span="1"></col><col width="84" span="1"></col><col width="61" span="1"></col><col width="68" span="1"></col><col width="84" span="1"></col><col width="107" span="1"></col><thead><tr><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Country, publication year</th><th colspan="3" valign="top" align="center" scope="colgroup" rowspan="1">Direct non–medical cost*</th><th valign="top" align="center" scope="col" rowspan="1" colspan="1">Indirect cost†</th><th rowspan="2" valign="top" align="center" scope="col" colspan="1">% of non–medical cost to monthly household income<hr></hr></th><th rowspan="2" valign="top" align="center" scope="col" colspan="1">Monthly household income (2013 US$)<hr></hr></th></tr></thead><tbody><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Total</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Transportation</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Food</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>Total</bold><hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Bangladesh, 2010 [</bold><xref rid="R24" ref-type="bibr">24</xref><bold>]</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">32.4<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">13.8%<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">234.9<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>India, 2002 [</bold><xref rid="R29" ref-type="bibr">29</xref><bold>]</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">5.3<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">5.3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">47.5<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">2.0%<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">264.0<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Pakistan, 2008 [</bold><xref rid="R19" ref-type="bibr">19</xref><bold>]</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">35.9<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">12.2<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">23.7<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">10.6%<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">338.3<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Pakistan, 2006 [</bold><xref rid="R20" ref-type="bibr">20</xref><bold>]</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">55.0<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">16.3%<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">338.3<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Pakistan, 2012 [</bold><xref rid="R23" ref-type="bibr">23</xref><bold>]</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">3.3<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">2.3<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1.0<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">9.6<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1.0%<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">338.3<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Kenya, 2009 [</bold><xref rid="R32" ref-type="bibr">32</xref><bold>]</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">14.0<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">9.0%<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">155.8<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Guinea, 1998 [</bold><xref rid="R21" ref-type="bibr">21</xref><bold>]</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">30.0<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">31.0%<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">96.7‡<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>South Africa, 2012 [</bold><xref rid="R22" ref-type="bibr">22</xref><bold>]</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">2.0<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1.4<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">0.2<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">0.5%<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">434.8<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Fiji, 2012 [</bold><xref rid="R34" ref-type="bibr">34</xref><bold>]</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">33.2<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">33.2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">4.9<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">5.3%<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">632.5‡<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Brazil, 2011*</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">9.7<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">8.41<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1.31<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">73.1<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1.6%<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">626.8<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Mean (95% CI)</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>22.0 (11.8–32.7)</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>10.5 (3.5–22.3)</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>8.7 (1.0–23.7)</bold><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>27.0 (4.0–54.3)</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Median (IQR)</bold></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>22.0 (4.6 –33.9)</bold></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>6.9 (2.1–11.5)</bold></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>1.3 (–)</bold></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>9.6 (2.5–60.3)</bold></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><p>CI – confidence interval, IQR – interquartile range</p><p>*Direct medical costs include medications and consultation, non–medical cost includes transportation, food and accommodation.</p><p>†Indirect cost refers to parental loss of earnings in the period of illness. Monthly household income (2013 US$) was derived from Gallup World Poll annual median household income, equals annual median household income divided by 12. These results were based on Gallup data gathered between 2006 and 2012 in 131 populations. Source: <ext-link ext-link-type="uri" xlink:href="http://www.gallup.com/poll/166211/worldwide-median-household-income-000.aspx">http://www.gallup.com/poll/166211/worldwide-median-household-income-000.aspx</ext-link>.</p><p>‡Numbers used GNI per capita based on purchasing power parity (PPP) due to lack of monthly household income data. PPP GNI is gross national income (GNI) converted to international dollars using purchasing power parity rates. An international dollar has the same purchasing power over GNI as a US dollar has in the United States. GNI is the sum of value added by all resident producers plus any product taxes (less subsidies) not included in the valuation of output plus net receipts of primary income (compensation of employees and property income) from abroad. Source: <ext-link ext-link-type="uri" xlink:href="http://data.worldbank.org/indicator/NY.GNP.PCAP.PP.CD/countries">http://data.worldbank.org/indicator/NY.GNP.PCAP.PP.CD/countries</ext-link>.</p></table-wrap-foot></table-wrap></sec><sec><title>Length of stay in hospital</title><p>The in–patient cost was determined primarily by the length of stay (LOS) and the average cost per bed day. In this review, we extracted length of stay for severe pneumonia for future costing analysis reference (<xref ref-type="table" rid="T6"><bold>Tables 6–8</bold></xref><xref ref-type="table" rid="T7"></xref><xref ref-type="table" rid="T8"></xref>).</p><table-wrap id="T6" orientation="portrait" position="float"><label>Table 6</label><caption><p>Length of stay of very severe pneumonia and severe pneumonia in hospital in high–income countries</p></caption><table frame="hsides" rules="groups"><col width="112" span="1"></col><col width="112" span="1"></col><col width="112" span="1"></col><col width="112" span="1"></col><thead><tr><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Country and year</th><th valign="top" align="center" scope="col" rowspan="1" colspan="1">Setting</th><th valign="top" align="center" scope="col" rowspan="1" colspan="1">LOS (SD) days</th><th valign="top" align="center" scope="col" rowspan="1" colspan="1">Sample size</th></tr></thead><tbody><tr><td colspan="4" valign="top" align="left" scope="col" rowspan="1"><bold>Very severe pneumonia:</bold><hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Germany, 2005 [<xref rid="R16" ref-type="bibr">16</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">ICU<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">7.4 (6.1)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">2039<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Spain, 2013 [<xref rid="R17" ref-type="bibr">17</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">ICU<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">18.0<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">99<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">USA, 2012*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">ICU<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">18.3 (43.1)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1116<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Australia, 2011*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">ICU<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">11.0<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Median (IQR)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">14.5 (10.1–18.1)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td colspan="4" valign="top" align="left" scope="col" rowspan="1"><bold>Severe pneumonia:</bold><hr></hr></td></tr><tr><td rowspan="2" valign="top" align="left" scope="row" colspan="1">Ireland, 1999 [<xref rid="R13" ref-type="bibr">13</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Control group<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">8.3 (7.7–9.0)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">44<hr></hr></td></tr><tr><td valign="top" colspan="1" align="center" scope="row" rowspan="1">New treatment group<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">4.0 (3.5–4.6)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">45<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Germany, 2005 [<xref rid="R16" ref-type="bibr">16</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Hospitalised cases<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">7.4 (6.1)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">2039<hr></hr></td></tr><tr><td rowspan="2" valign="top" align="left" scope="row" colspan="1">Australia, 2008 [<xref rid="R14" ref-type="bibr">14</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Without impact diary<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">8.8<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">202<hr></hr></td></tr><tr><td valign="top" colspan="1" align="center" scope="row" rowspan="1">With impact diary<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">13.5<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">523<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Australia, 2011*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Non–ICU<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.0<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Spain, 2013 [<xref rid="R17" ref-type="bibr">17</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Non–ICU<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">10.5<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">99<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">USA, 2012*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Non–ICU<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">2.7 (2.3)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">940<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Median (IQR)</bold></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>7.9 (5.5–9.2)</bold></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><p>IQR – interquartile range, ICU – intensive care unit</p><p>*Unpublished data.</p></table-wrap-foot></table-wrap><table-wrap id="T7" orientation="portrait" position="float"><label>Table 7</label><caption><p>Length of stay of severe pneumonia in hospital in low– and middle–income countries</p></caption><table frame="hsides" rules="groups"><col width="113" span="1"></col><col width="113" span="1"></col><col width="113" span="1"></col><col width="113" span="1"></col><thead><tr><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Country, year</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Description</th><th valign="top" align="center" scope="col" rowspan="1" colspan="1">Length of stay (SD) in days‡</th><th valign="top" align="center" scope="col" rowspan="1" colspan="1">Sample size</th></tr></thead><tbody><tr><td rowspan="4" valign="top" align="left" scope="row" colspan="1"><bold>Viet Nam, 2010 </bold>[<xref rid="R18" ref-type="bibr">18</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Probable pneumonia<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">7.2 (5.0)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">40<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Radiograph confirmed<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.7 (3.8)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">426<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Probable severe pneumonia<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.2 (3.3)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">59<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Radiograph confirmed severe pneumonia<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.4 (2.7)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">193<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Bangladesh, 2010 </bold>[<xref rid="R24" ref-type="bibr">24</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Hospital care<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.0 (5.0–7.0)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">180<hr></hr></td></tr><tr><td rowspan="2" valign="top" align="left" scope="row" colspan="1"><bold>Bangladesh, 2005*</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Public health care<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">7.1<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">73<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Private health care<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.4<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">41<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Bangladesh, 2010*</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Hospital stay<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">7.0 (3.0)†<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">93<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Pakistan, 2003 </bold>[<xref rid="R25" ref-type="bibr">25</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Antibiotic use duration<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">Approx. 8<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">124<hr></hr></td></tr><tr><td rowspan="7" valign="top" align="left" scope="row" colspan="1"><bold>Kenya, 2009 </bold>[<xref rid="R32" ref-type="bibr">32</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">National hospitals<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">8.2<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">49<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">District hospitals<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.7<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">30<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">District hospitals<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">4.8<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">29<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">District hospitals<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">4.2<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">17<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Provincial hospitals<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.6<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">31<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Mission Hospitals<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">7.8<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">30<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Mission Hospitals<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">3.4<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">19<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Zambia, 2009 </bold>[<xref rid="R31" ref-type="bibr">31</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Tertiary health center<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">4.0<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">221<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Pakistan, 2008 </bold>[<xref rid="R19" ref-type="bibr">19</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Time spent at health facility for severe pneumonia<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">3.3<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">65<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Pakistan, 2006 </bold>[<xref rid="R20" ref-type="bibr">20</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Secondary hospital<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">3.0<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">502<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Jordan, 2010 </bold>[<xref rid="R35" ref-type="bibr">35</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">In–patient days<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">4.0–5.0<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">728<hr></hr></td></tr><tr><td rowspan="2" valign="top" align="left" scope="row" colspan="1"><bold>India, 2009 </bold>[<xref rid="R30" ref-type="bibr">30</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Secondary hospital<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">3.5 (2.9–4.1)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">31<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Tertiary hospital<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">3.7 (3.0–4.4)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">25<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>India, 2002 </bold>[<xref rid="R29" ref-type="bibr">29</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Tertiary hospital<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.5 (2.5)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">52<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Brazil, 2011*</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Public health system<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">3.9 (2.2)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">59<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Supplementary health system<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">5.3 (4.7)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">20<hr></hr></td></tr><tr><td rowspan="3" valign="top" align="left" scope="row" colspan="1"><bold>Colombia, 2013 </bold>[<xref rid="R27" ref-type="bibr">27</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Primary<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">2.0 (1.0–2.0)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">247<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Secondary hospital<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">4.0 (1.0–5.0)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1208<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Tertiary hospital<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.0 (3.0–9.0)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">47<hr></hr></td></tr><tr><td rowspan="2" valign="top" align="left" scope="row" colspan="1"><bold>South Africa, 2011 </bold>[<xref rid="R33" ref-type="bibr">33</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Public sector ward<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">8.7<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">86<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Fee for service sector<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">5.6<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">7786<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>South Africa, 2012 </bold>[<xref rid="R22" ref-type="bibr">22</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Paediatric ward<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">8.1 (7.4–8.8)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">513<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Indonesia, 2001*</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Non–ICU<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.7<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td></tr><tr><td rowspan="3" valign="top" align="left" scope="row" colspan="1"><bold>Argentina, 2012*</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Severe pneumonia<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">7.5(8.5)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">42<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Unilateral focal pneumonia without complications<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">7.4 (6.0)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1994<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Multifocal pneumonia without complications<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">8.0 (6.5)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">323<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Median (IQR)</bold></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>6.4 (4.1–7.1)</bold></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><p>ICU – intensive care unit</p><p>*Unpublished data..</p><p>†Combined HIV+ and HIV–, HIV+ had longer stay in ward (9.3 vs 7.0 days)</p><p>‡Length of stay (LOS) reported as mean, mean (standard deviation) or median (interquartile range). When stratified LOS available, then stratified LOS was reported, not average length of stay of all pneumonia.</p></table-wrap-foot></table-wrap><table-wrap id="T8" orientation="portrait" position="float"><label>Table 8</label><caption><p>Length of stay of very severe and non–severe pneumonia in hospital in low– and middle–income countries</p></caption><table frame="hsides" rules="groups"><col width="115" span="1"></col><col width="115" span="1"></col><col width="115" span="1"></col><col width="77" span="1"></col><thead><tr><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Country, year</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Description</th><th valign="top" align="center" scope="col" rowspan="1" colspan="1">Length of stay (SD) days</th><th valign="top" align="center" scope="col" rowspan="1" colspan="1">Sample size</th></tr></thead><tbody><tr><td valign="top" align="left" scope="col" rowspan="1" colspan="1"><bold>Very severe pneumonia</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td rowspan="2" valign="top" align="left" scope="row" colspan="1">Viet Nam, 2010 [<xref rid="R18" ref-type="bibr">18</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Very severe pneumonia<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.4(2.7)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">26<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Confirmed very severe pneumonia<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">5.8 (3.0)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">44<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Colombia, 2013 [<xref rid="R27" ref-type="bibr">27</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">ICU<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">13.0 (6.0–14.0)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">43<hr></hr></td></tr><tr><td rowspan="2" valign="top" align="left" scope="row" colspan="1">South Africa, 2011 [<xref rid="R33" ref-type="bibr">33</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">ICU<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">9.4<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">46<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">ICU<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">10.5<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">93<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">South Africa, 2012 [<xref rid="R22" ref-type="bibr">22</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">ICU<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">14.4(10.3–18.5)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">7<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Pakistan, 2008 [<xref rid="R19" ref-type="bibr">19</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Time spend at health facility for very severe pneumonia<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">3.9<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">35<hr></hr></td></tr><tr><td rowspan="3" valign="top" align="left" scope="row" colspan="1">Argentina, 2012†<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Very severe pneumonia<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">8.9<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Unilateral focal pneumonia without complications<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">17.2<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Multifocal pneumonia without complications<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">11.5<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td></tr><tr><td rowspan="2" valign="top" align="left" scope="row" colspan="1">Brazil, 2011*<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Public health system<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.9<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Supplementary health system<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">–<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Median (IQR)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">9.2 (6.1–12.6)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" align="left" scope="col" rowspan="1" colspan="1"><bold>Non severe pneumonia</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">Pakistan, 2008 [<xref rid="R19" ref-type="bibr">19</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Time spend at health facility for pneumonia<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">0.3<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">41<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">South Africa, 2012 [<xref rid="R22" ref-type="bibr">22</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Short stay<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">1.4 (1.3–1.6)<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">338<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Median (IQR)</bold></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>0.9 (0.3–1.4)</bold></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><p>ICU – intensive care unit, IQR – interquartile range</p><p>*Unpublished data.</p><p>†Note added in proof: The data from this study are unpublished but the data on the length of stay are published in Giglio ND, Cane AD, Micone P, Gentile A. Cost-effectiveness of the CRM-based 7-valent pneumococcal conjugated vaccine (PCV7) in Argentina. Vaccine. 2010;28:2302-10. Medline:20064478.</p></table-wrap-foot></table-wrap><p>The mean LOS for severe pneumonia reported in individual studies ranged from 4–13.5 days, with a mean LOS 7.7 (95% CI 5.5–9.9) days and median 7.9 (IQR 5.5–9.2) days in HIC, and mean LOS 5.8 (95% CI IQR 5.3–6.4) days and median 6.4 (IQR 4.1–7.1) days in LMIC. For very severe pneumonia management in intensive care unit (ICU), LOS ranged from 7.4 to 18.3 days. The mean and median LOS were 13.7 (95% CI IQR 9.2–18.2) and 14.5 (IQR 10.1–18.1) days in HIC, and 9.5 (95%CI, 7.4–11.8) and 9.2 (IQR 6.1–12.6) days in LMIC.</p></sec><sec><title>Unit cost of case management</title><p>Unit cost of treatment and resource uptake should be routinely reported in cost studies. However, only 13 of the 34 included studies reported these data. Since treatment protocols (use of antibiotics, diagnostic tests, procedures and levels and intensity of care) varied between studies, this contributed to variations in costs across studies. For example, the average cost of chest radiograph in LMIC was US$ 8.4 (95% CI 4.3–27.0), which was significantly lower than US$ 185.5 (95% CI 66.3–357.7) in high income countries (<xref ref-type="table" rid="T9"><bold>Table 9</bold></xref>). We attempted to abstract unit cost data but were unable to include it in the presented direct medical costs because of paucity of information.</p><table-wrap id="T9" orientation="portrait" position="float"><label>Table 9</label><caption><p>Chest Radiography cost per episode</p></caption><table frame="hsides" rules="groups"><col width="101" span="1"></col><col width="101" span="1"></col><col width="162" span="1"></col><thead><tr><th colspan="2" valign="top" align="left" scope="colgroup" rowspan="1">Country, year</th><th valign="top" align="center" scope="col" rowspan="1" colspan="1">Cost per episode (2013 US$)</th></tr></thead><tbody><tr><td rowspan="4" valign="top" align="left" scope="row" colspan="1"><bold>High income countries</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Australia, 2011*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">129.8<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Chile, 2007 [<xref rid="R12" ref-type="bibr">12</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">135.1<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Uruguay, 2007 [<xref rid="R12" ref-type="bibr">12</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">43.4<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">United States, 2012*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">433.7<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Mean(SD)</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>185.5 (66.3–357.7)</bold><hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Median(IQR)</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>132.5 (108.2–209.8)</bold><hr></hr></td></tr><tr><td rowspan="13" valign="top" align="left" scope="row" colspan="1"><bold>Low– and middle–income countries</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Argentina, 2012*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">26.7<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Brazil, 2011*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">10.7<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">6.0<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Brazil, 2007 [<xref rid="R12" ref-type="bibr">12</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">13.63<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Bangladesh, 2010*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">2.3<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">India, 2009 [<xref rid="R30" ref-type="bibr">30</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">5.4<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Pakistan, 2008 [<xref rid="R19" ref-type="bibr">19</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">3.2<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Indonesia, 2001*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">4.6<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Kenya, 2009 [<xref rid="R32" ref-type="bibr">32</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">2.3<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">South Africa, 2001*<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">29.7<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">South Africa, 2011 [<xref rid="R33" ref-type="bibr">33</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">59.7<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">137.2<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">South Africa, 2012 [<xref rid="R22" ref-type="bibr">22</xref>]<hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1">27.7<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Mean (SD)</bold><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1"><hr></hr></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>25.3 (9.8–47.3)</bold><hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1"><bold>Median (IQR)</bold></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>8.4 (4.3–27.0)</bold></td></tr></tbody></table><table-wrap-foot><p>*Unpublished data.</p></table-wrap-foot></table-wrap></sec></sec><sec sec-type="discussion"><title>DISCUSSION</title><p>This is the first attempt to conduct a systematic review of all published and available unpublished cost data on the management of childhood pneumonia. Costs per episodes in HICs were 5–13–fold higher in all delivery channels than those in LMICs. The review demonstrates that the magnitude of cost per episode increases markedly as the level of treatment delivery rises. Community management for severe pneumonia was less than 10% that of the cost of out–patient management among all levels of management in LMICs. Thus, there are strong economic reasons for considering community case management as a central strategy for pneumonia case management in low income countries; this merits further evaluation which should include consideration of medical outcomes. The mean lengths of stay in hospital for severe pneumonia were 1.8–4.6 days less in LMIC compared to HIC, and at a mean of 5.8 and median of 6.4 days, were close to the WHO recommendation of 5 days in–patient treatment [<xref rid="R10" ref-type="bibr">10</xref>].</p><p>We demonstrated that the cost (per episode) for the management of severe pneumonia varied greatly by unit cost of intervention, disease severity and treatment procedures in different settings. The review also demonstrated that major factors governing the total cost per episode were length of stay in the hospital, countries income level and the presence or absence of community case management for pneumonia. Many other studies have also found GDP per capita to be the main driver of costs [<xref rid="R37" ref-type="bibr">37</xref>]. These findings demonstrate that choosing the appropriate value for these inputs will have a significant influence on the total cost. Existing studies calculated pneumonia management costs in many countries assuming the same treatment procedure and unit cost of medicine. However, the cost data we collected demonstrate that this method may have limitations; the uncertainty in the traditional estimates can be measured using the cost data reported in this review.</p><p>Our results showed that direct medical costs for childhood pneumonia management, especially inpatients, represent a significant proportion of the average monthly household income for families in LMICs. This is often compounded by further direct non–medical cost and indirect cost ie, loss of earnings when caring for the sick child. In countries where these families were uninsured, health payments for pneumonia management were a heavy burden on household and can have a significant impact on the family, particularly when the payments for care were out–of–pocket in most LMIC countries. Alamgir et al investigated the impact that this strain had on families and how they source the funds: many borrow or take high–interest loans [<xref rid="R26" ref-type="bibr">26</xref>]. Furthermore, Ayieko et al found that 10% of the patients in district hospitals and up to 25% of children in tertiary hospitals wait in hospital beds after medical discharge while families source the fees. The latter translates to an additional cost of US$ 17.46 to the public provider and US$ 5.32 to the family [<xref rid="R32" ref-type="bibr">32</xref>], resulting in a drain on both the resources of the family and the health care provider, as well as denying a bed to another sick child. It is therefore important that national strategies for pneumonia management in LMIC are not only cost–effective for the national program but also give attention to the burden of costs on families so that these are maintained at a level that is affordable.</p><p>The data in this review comprise “actual” cost data measured in cost studies conducted in many LMIC and HIC. We believe that these represent a fair first approximation of true costs in these countries. It is noteworthy that the resulting cost estimates are higher than those currently contained in the WHO–CHOICE estimates [<xref rid="R38" ref-type="bibr">38</xref>]. Three factors could have contributed to this variation. First, we identified longer facility and hospital stays compared to standard treatment protocols recommended by the WHO [<xref rid="R39" ref-type="bibr">39</xref>]. Moreover, most existing cost studies were conducted at tertiary level hospitals where out–patient and in–patient treatments carry a much higher cost compared to the community or first level facility. Third, the wide variety of antibiotics (including variations in dosage, route of administration and duration) across the sites, as well as the heterogeneity in the costing methodology and the cost components in existing studies may have led to higher estimates.</p><p>This review has several limitations. First, the primary goal of the systematic review was to obtain data on cost of management (per episode) of severe pneumonia. However, the lack of any standard management protocols (which varied widely across the included studies) and the general lack of service uptake data, may have contributed to the substantial uncertainty around the estimates. Second, we did not include costs of diagnostic investigations in the cost modeling in some study sites, because country–specific unit prices and utilization data were not available. Therefore, the true economic burden resulting from the management of childhood pneumonia could be considerably higher. Third, costs were highly dependent on level of care offered at facility and LOS could be skewed to longer period if high level of care (such as intensive care unit (ICU) care) was offered to severe and very severe cases. In this review, severe cases were all managed at non–ICU hospital settings, and very severe cases were managed at both non–ICU and ICU care in hospital settings. We were able to report LOS separately for non–ICU and ICU care but this stratification was not possible for total cost per episode. A further limitation was that the definition of ICU and ICU care may vary by country. Fourthly, we limited the search to English articles only, which may exclude some cost reported in other languages, however only 13 studies out of 789 articles in other languages were found. We tried to compliment this with unpublished data from non–English speaking countries. Lastly, there was a wide range in per capita income and health care system and payment schemes within LMIC category and the existing cost data may only reflect the situation when and where the data were collected and may not be representative of the whole country or the current situation. Furthermore, there were not sufficient studies to address all possible cost scenarios to facilitate international and public/private comparisons.</p><p>Our results demonstrate that further research on the economic burden due to the management of childhood pneumonia is needed, with clear reporting of data on unit cost of intervention, dosage of various drugs and information on health care utilization, such as length of stay in hospital. We recommend that standard reporting of unit cost of intervention with direct medical and non–medical costs and indirect costs, standard treatment protocols and health resource utilization in conjunction with the total cost per episode in any cost–of–illness studies would facilitate economic estimates of national scale–up and international comparisons. Further studies on the cost–effectiveness of standardized IMCI protocol against other treatment protocols could be expected to find a cost–saving management strategy for high burden countries.</p><p>Identifying the most cost–effective interventions for pneumonia management is essential for achieving the goal of further reducing child mortality. Our study demonstrated that early treatment in the community costs less (per event) than late treatment in the hospital. This finding suggests that the public health community should explore ways for community outreach for early diagnosis and treatment before severe pneumonia sets in. The results from this systematic review provide important missing information on the cost of pneumonia treatment in children across many countries. These data and the cost estimates should provide important information useful to program managers and policy makers at national and regional levels, international agencies, and donor organisations to aid resource allocation, program planning and priority setting. The estimates presented in this review could enable a more detailed economic evaluation of the revised WHO pneumonia management guidelines [<xref rid="R39" ref-type="bibr">39</xref>], and help identify the most cost–effective preventive and treatment interventions for reducing the burden of childhood pneumonia.</p></sec><sec><title></title><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Characteristics of all studies included*</p></caption><table frame="hsides" rules="groups"><col width="61" span="1"></col><col width="61" span="1"></col><col width="61" span="1"></col><col width="61" span="1"></col><col width="62" span="1"></col><col width="62" span="1"></col><col width="62" span="1"></col><col width="62" span="1"></col><col width="62" span="1"></col><col width="62" span="1"></col><col width="62" span="1"></col><thead><tr><th valign="top" align="left" scope="col" rowspan="1" colspan="1">WHO region</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Country, publication year</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Study population</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Healthcare setting</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Severity of pneumonia studied</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Study design</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Source of case definition</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Perspective</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Sample size</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Mean (SD) /median age of patients (months)</th><th valign="top" align="left" scope="col" rowspan="1" colspan="1">Data source</th></tr></thead><tbody><tr><td colspan="11" valign="top" align="left" scope="col" rowspan="1"><bold>High–income countries (number of studies = 8)</bold><hr></hr></td></tr><tr><td rowspan="3" valign="top" align="left" scope="row" colspan="1">EUR<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Northern Ireland, 1999 [<xref rid="R39" ref-type="bibr">39</xref>]<sup>1</sup><hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Antrim (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">QES<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A–<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">45<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">39.60 (16.8)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Spain, 2013 [<xref rid="R17" ref-type="bibr">17</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Barcelona (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost analysis‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Culture–proved pneumonia<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">101<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">39.60<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Germany, 2005 [<xref rid="R16" ref-type="bibr">16</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">National<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">O,H1<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">402<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N, IQ<hr></hr></td></tr><tr><td rowspan="2" valign="top" align="left" scope="row" colspan="1">AMR<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Chile, Uruguay, 2007 [<xref rid="R12" ref-type="bibr">12</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">National<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">O,H1<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, NS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost analysis‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD, ICD–10<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">366<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H,IQ<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">United States, 2012*<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Denver, Colorado (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS, NS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">940<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">0–59<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H, P<hr></hr></td></tr><tr><td rowspan="3" valign="top" align="left" scope="row" colspan="1">WPR<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Australia, 2008 [<xref rid="R15" ref-type="bibr">15</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">National<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">O, H1–3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost analysis‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">ICD–10<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">1348<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Australia, 2008 [<xref rid="R14" ref-type="bibr">14</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Melbourne, Victoria (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">O,H1<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cohort study/cost–of–illness<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Health professional’s diagnosis<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">528<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N,H,IQ, Pilot<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Australia, 2011*<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Sydney (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">P, Market price<hr></hr></td></tr><tr><td colspan="11" valign="top" align="left" scope="col" rowspan="1"><bold>Low– and middle–income countries (number of studies = 27)</bold><hr></hr></td></tr><tr><td rowspan="15" valign="top" align="left" scope="row" colspan="1">SEAR<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Bangladesh, 2010 [<xref rid="R26" ref-type="bibr">26</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Dhaka (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Family<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">90<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">5.00<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">IQ<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Bangladesh, 2005†<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Dhaka (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Household<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">114<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">70.32<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">IQ<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Bangladesh, 2010 [<xref rid="R24" ref-type="bibr">24</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Mirpur, Dhaka (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">O, H2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">RCT/CEA<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">360<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">8.00<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">–<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Bangladesh, 2010†<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Barishal, Bogra, Comilla, Kishoregonj (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, NS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">235<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">IQ<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Bangladesh, 2012†<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Mohakhali, Dhaka (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS, NS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">340<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">India, 2009 [<xref rid="R30" ref-type="bibr">30</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Vellore (rural)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H1, H2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare/ Household<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">56<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">8.8<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H, IQ<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">India, 2002 [<xref rid="R29" ref-type="bibr">29</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Berhampur, Orissa (urban and rural)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Epidemiological study<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">52<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H, IQ<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Indonesia, 2001†<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Lombok (rural)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Pakistan, 2003 [<xref rid="R25" ref-type="bibr">25</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Peshawar city (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">RCT/CEA<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">–<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">126<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">–<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Pakistan, 2006 [<xref rid="R20" ref-type="bibr">20</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Ghizer district (rural)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">O, H1, H2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, NS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost analysis‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">502<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">IQ<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Pakistan, 2008 [<xref rid="R19" ref-type="bibr">19</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Ghizer district (rural)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">O, H1, H2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS, NS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost analysis‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">141<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">IQ<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Pakistan, 2010†<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Matiari (rural)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">C<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Surveillance<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Pakistan, 2012 [<xref rid="R23" ref-type="bibr">23</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Haripur district (rural)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">C, H1, H2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost analysis‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">WHO definition by health worker<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Household<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">423<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H, IQ<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Viet Nam, 2010 [<xref rid="R18" ref-type="bibr">18</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Nha Trang city (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS, NS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">788<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">12.67<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N, H<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Viet Nam, 2001 [<xref rid="R28" ref-type="bibr">28</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Ba Vi district (rural)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">C, O, H1<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost analysis‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">WHO definition, self–reported<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Household<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">94<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">IQ<hr></hr></td></tr><tr><td rowspan="6" valign="top" align="left" scope="row" colspan="1">AFR<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Guinea, 1998 [<xref rid="R21" ref-type="bibr">21</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">National<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">O, H1<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, NS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">CEA<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">–<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">73650<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H, E<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">South Africa, 2011 [<xref rid="R33" ref-type="bibr">33</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Pretoria (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost analysis‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">WHO definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">–<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">3014<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">South Africa, 2012 [<xref rid="R22" ref-type="bibr">22</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">National<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS, NS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">RCT<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal/health care<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">745<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H, IQ<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">South Africa, 2001†<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Soweto (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">509<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">14.00<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H,IQ<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Kenya, 2009 [<xref rid="R32" ref-type="bibr">32</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">National<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3, H2, H1<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost analysis‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">205<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">12.00<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H, IQ<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Zambia, 2009 [<xref rid="R31" ref-type="bibr">31</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Kanyama Township (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">O,H2<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost analysis‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">9146<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N,H,P,W<hr></hr></td></tr><tr><td rowspan="4" valign="top" align="left" scope="row" colspan="1">AMR<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Colombia, 2013 [<xref rid="R27" ref-type="bibr">27</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">National<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H1,H2,H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS, NS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness§<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">WHO definition, radiographically diagnosed<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">1545<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">I<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Brazil, 2011†<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Goiânia (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness§<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">79<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">0–36<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H, N<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Argentina, 2012†<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Buenos Aires (urban)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H3<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, VS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost–of–illness§<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N<hr></hr></td></tr><tr><td valign="top" colspan="1" align="left" scope="row" rowspan="1">Brazil,2007 [<xref rid="R12" ref-type="bibr">12</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">National<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">O,H1<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S, NS<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost analysis‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD, ICD–10<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Healthcare<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">366<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">H,IQ<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">WPR<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Fiji, 2012 [<xref rid="R34" ref-type="bibr">34</xref>]<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Viti Levu (urban and rural)<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">O<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">S<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Cost analysis‡<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">PD by WHO IMCI definition<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">Societal/household<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">390<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N/A<hr></hr></td><td valign="top" align="left" rowspan="1" colspan="1">N,H, IQ<hr></hr></td></tr><tr><td valign="top" align="left" scope="row" rowspan="1" colspan="1">EMR</td><td valign="top" align="left" rowspan="1" colspan="1">Jordan, 2010 [<xref rid="R35" ref-type="bibr">35</xref>]</td><td valign="top" align="left" rowspan="1" colspan="1">Amman</td><td valign="top" align="left" rowspan="1" colspan="1">H1</td><td valign="top" align="left" rowspan="1" colspan="1">S</td><td valign="top" align="left" rowspan="1" colspan="1">Cohort study</td><td valign="top" align="left" rowspan="1" colspan="1">PD</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">728</td><td valign="top" align="left" rowspan="1" colspan="1">4.30</td><td valign="top" align="left" rowspan="1" colspan="1">N/A</td></tr></tbody></table><table-wrap-foot><p>*Severity of pneumonia: NS – non severe, S – severe, VS – very severe. Data source: H – hospital records, N – national data, IQ – interviews and questionnaires, I – insurance database, P – pharmacy database, W – WHO database. Treatment settings: H3 – tertiary hospital in–patient, H2–secondary hospital in–patient, H1 – primary hospital inpatient, O – out–patient care, C – community ambulatory care; PD – physician’s diagnosis, CEA – cost effectiveness analysis, RCT – randomized clinical trial, QES– quasi–experimental study, N/A – not available, PD – physician’s diagnosis, IMCI – Integrated Management of Childhood Illness, WHO – World Health Organization, SD – standard deviation.</p><p>EUR – Europe Region, AMR – the Americas Region, WPR – Western Pacific Region, SEAR – South East Asia, AFR– The Africa Region, EMR– Eastern Mediterranean Region</p><p>†Unpublished data.</p><p>‡The analysis of the comparative costs of alternative treatments or health care programmes.</p><p>§The cost analysis of treatment of a disease.</p></table-wrap-foot></table-wrap></sec></body><back><ack><title>Acknowledgments</title><p>The authors thank the Maternal Neonatal Child and Adolescent Health (MNCAH) division of the WHO for funding the study and China Scholarship Council for the fellowship to SZ.</p><p><bold>Funding:</bold> Shanshan Zhang is supported by WHO Maternal, Newborn, Child and Adolescent Health division and China Scholarship Council. Harish Nair and Harry Campbell received funding support from WHO Maternal, Newborn, Child and Adolescent Health division and Bill and Melinda Gates Foundation (OPP 1096225).</p><p><bold>Authorship declaration:</bold> HN and HC conceived the study. SZ and HN designed the study. PMS, IK, SZ, CMT, SNA, AS, JKY, TMH, NG, MUB, BDG, PJCL, JAC, IA and RK performed the experiments. SZ analysed the data. SZ, HN and HC wrote the paper. AA, CMT, AS, SAM, GK, RB, SEA, QSR, AG, KSR, BDG, MN, PJCL, EAFS, ZAB and SBS critically reviewed the manuscript:. All authors have read, and confirm that they meet, ICMJE criteria for authorship.</p><p><bold>Competing interests:</bold> HC is an editor–in–chief of the <italic>Journal of Global Health</italic>. To ensure that any possible conflict of interest relevant to the journal has been addressed, this article was reviewed according to best practice guidelines of international editorial organizations. All authors have completed the Unified Competing Interest form at <ext-link ext-link-type="uri" xlink:href="http://www.icmje.org/coi_disclosure.pdf">www.icmje.org/coi_disclosure.pdf</ext-link> (available on request from the corresponding author). 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