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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">In vitro Quality of Platelets with Low Plasma Carryover Treated with Ultraviolet C Light for Pathogen Inactivation</title><author><name sortKey="Johnson, Lacey" sort="Johnson, Lacey" uniqKey="Johnson L" first="Lacey" last="Johnson">Lacey Johnson</name><affiliation><nlm:aff id="aff1">Research and Development, Australian Red Cross Blood Service, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Hyland, Ryan" sort="Hyland, Ryan" uniqKey="Hyland R" first="Ryan" last="Hyland">Ryan Hyland</name><affiliation><nlm:aff id="aff1">Research and Development, Australian Red Cross Blood Service, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Tan, Shereen" sort="Tan, Shereen" uniqKey="Tan S" first="Shereen" last="Tan">Shereen Tan</name><affiliation><nlm:aff id="aff1">Research and Development, Australian Red Cross Blood Service, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Tolksdorf, Frank" sort="Tolksdorf, Frank" uniqKey="Tolksdorf F" first="Frank" last="Tolksdorf">Frank Tolksdorf</name><affiliation><nlm:aff id="aff2">MacoPharma International GmbH, Langen, Germany</nlm:aff></affiliation></author><author><name sortKey="Sumian, Chryslain" sort="Sumian, Chryslain" uniqKey="Sumian C" first="Chryslain" last="Sumian">Chryslain Sumian</name><affiliation><nlm:aff id="aff3">MacoPharma, Tourcoing, France</nlm:aff></affiliation></author><author><name sortKey="Seltsam, Axel" sort="Seltsam, Axel" uniqKey="Seltsam A" first="Axel" last="Seltsam">Axel Seltsam</name><affiliation><nlm:aff id="aff4">German Red Cross Blood Service NSTOB, Springe, Germany</nlm:aff></affiliation></author><author><name sortKey="Marks, Denese" sort="Marks, Denese" uniqKey="Marks D" first="Denese" last="Marks">Denese Marks</name><affiliation><nlm:aff id="aff1">Research and Development, Australian Red Cross Blood Service, Sydney, NSW, Australia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27403091</idno><idno type="pmc">4924470</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924470</idno><idno type="RBID">PMC:4924470</idno><idno type="doi">10.1159/000441830</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000502</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000502</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">In vitro Quality of Platelets with Low Plasma Carryover Treated with Ultraviolet C Light for Pathogen Inactivation</title><author><name sortKey="Johnson, Lacey" sort="Johnson, Lacey" uniqKey="Johnson L" first="Lacey" last="Johnson">Lacey Johnson</name><affiliation><nlm:aff id="aff1">Research and Development, Australian Red Cross Blood Service, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Hyland, Ryan" sort="Hyland, Ryan" uniqKey="Hyland R" first="Ryan" last="Hyland">Ryan Hyland</name><affiliation><nlm:aff id="aff1">Research and Development, Australian Red Cross Blood Service, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Tan, Shereen" sort="Tan, Shereen" uniqKey="Tan S" first="Shereen" last="Tan">Shereen Tan</name><affiliation><nlm:aff id="aff1">Research and Development, Australian Red Cross Blood Service, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Tolksdorf, Frank" sort="Tolksdorf, Frank" uniqKey="Tolksdorf F" first="Frank" last="Tolksdorf">Frank Tolksdorf</name><affiliation><nlm:aff id="aff2">MacoPharma International GmbH, Langen, Germany</nlm:aff></affiliation></author><author><name sortKey="Sumian, Chryslain" sort="Sumian, Chryslain" uniqKey="Sumian C" first="Chryslain" last="Sumian">Chryslain Sumian</name><affiliation><nlm:aff id="aff3">MacoPharma, Tourcoing, France</nlm:aff></affiliation></author><author><name sortKey="Seltsam, Axel" sort="Seltsam, Axel" uniqKey="Seltsam A" first="Axel" last="Seltsam">Axel Seltsam</name><affiliation><nlm:aff id="aff4">German Red Cross Blood Service NSTOB, Springe, Germany</nlm:aff></affiliation></author><author><name sortKey="Marks, Denese" sort="Marks, Denese" uniqKey="Marks D" first="Denese" last="Marks">Denese Marks</name><affiliation><nlm:aff id="aff1">Research and Development, Australian Red Cross Blood Service, Sydney, NSW, Australia</nlm:aff></affiliation></author></analytic><series><title level="j">Transfusion Medicine and Hemotherapy</title><idno type="ISSN">1660-3796</idno><idno type="eISSN">1660-3818</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><sec><title>Background</title><p>The THERAFLEX UV-Platelets system uses shortwave ultraviolet C light (UVC, 254 nm) to inactivate pathogens in platelet components. Plasma carryover influences pathogen inactivation and platelet quality following treatment. The plasma carryover in the standard platelets produced by our institution are below the intended specification (<30%).</p></sec><sec><title>Methods</title><p>A pool and split study was carried out comparing untreated and UVC-treated platelets with <30% plasma carryover (n = 10 pairs). This data was compared to components that met specifications (>30% plasma). The platelets were tested over storage for in vitro quality.</p></sec><sec><title>Results</title><p>Platelet metabolism was accelerated following UVC treatment, as demonstrated by increased glucose consumption and lactate production. UVC treatment caused increased externalization of phosphatidylserine on platelets and microparticles, activation of the GPIIb/IIIa receptor (PAC-1 binding), and reduced hypotonic shock response. Platelet function, as measured with thrombelastogram, was not affected by UVC treatment. Components with <30% plasma were similar to those meeting specification with the exception of enhanced glycolytic metabolism.</p></sec><sec><title>Conclusion</title><p>This in vitro analysis demonstrates that treatment of platelets with <30% plasma carryover with the THERAFLEX UV-Platelets system affects some aspects of platelet metabolism and activation, although in vitro platelet function was not negatively impacted. This study also provides evidence that the treatment specifications of plasma carryover could be extended to below 30%.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Transfus Med Hemother</journal-id><journal-id journal-id-type="iso-abbrev">Transfus Med Hemother</journal-id><journal-id journal-id-type="publisher-id">TMH</journal-id><journal-title-group><journal-title>Transfusion Medicine and Hemotherapy</journal-title></journal-title-group><issn pub-type="ppub">1660-3796</issn><issn pub-type="epub">1660-3818</issn><publisher><publisher-name>S. Karger GmbH</publisher-name><publisher-loc>Wilhelmstrasse 20A, P.O. Box · Postfach · Case postale, D–79095, Freiburg, Germany · Deutschland · Allemagne, Phone: +49 761 45 20 70, Fax: +49 761 4 52 07 14, information@karger.de</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27403091</article-id><article-id pub-id-type="pmc">4924470</article-id><article-id pub-id-type="doi">10.1159/000441830</article-id><article-id pub-id-type="publisher-id">tmh-0043-0190</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>In vitro Quality of Platelets with Low Plasma Carryover Treated with Ultraviolet C Light for Pathogen Inactivation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Lacey</given-names></name><xref ref-type="aff" rid="aff1">a</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Hyland</surname><given-names>Ryan</given-names></name><xref ref-type="aff" rid="aff1">a</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Shereen</given-names></name><xref ref-type="aff" rid="aff1">a</xref></contrib><contrib contrib-type="author"><name><surname>Tolksdorf</surname><given-names>Frank</given-names></name><xref ref-type="aff" rid="aff2">b</xref></contrib><contrib contrib-type="author"><name><surname>Sumian</surname><given-names>Chryslain</given-names></name><xref ref-type="aff" rid="aff3">c</xref></contrib><contrib contrib-type="author"><name><surname>Seltsam</surname><given-names>Axel</given-names></name><xref ref-type="aff" rid="aff4">d</xref></contrib><contrib contrib-type="author"><name><surname>Marks</surname><given-names>Denese</given-names></name><xref ref-type="aff" rid="aff1">a</xref></contrib></contrib-group><aff id="aff1"><sup>a</sup>Research and Development, Australian Red Cross Blood Service, Sydney, NSW, Australia</aff><aff id="aff2"><sup>b</sup>MacoPharma International GmbH, Langen, Germany</aff><aff id="aff3"><sup>c</sup>MacoPharma, Tourcoing, France</aff><aff id="aff4"><sup>d</sup>German Red Cross Blood Service NSTOB, Springe, Germany</aff><author-notes><corresp id="cor1">*Dr. Lacey Johnson, Research and Development, Australian Red Cross Blood Service, 17 O'Riordan St, Alexandria, NSW, 2015, Australia <email>Ljohnson@redcrossblood.org.au</email></corresp></author-notes><pub-date pub-type="ppub"><month>5</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>5</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>5</day><month>11</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>43</volume><issue>3</issue><fpage>190</fpage><lpage>197</lpage><history><date date-type="received"><day>30</day><month>4</month><year>2015</year></date><date date-type="accepted"><day>15</day><month>7</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 by S. Karger GmbH, Freiburg</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><title>Summary</title><sec><title>Background</title><p>The THERAFLEX UV-Platelets system uses shortwave ultraviolet C light (UVC, 254 nm) to inactivate pathogens in platelet components. Plasma carryover influences pathogen inactivation and platelet quality following treatment. The plasma carryover in the standard platelets produced by our institution are below the intended specification (<30%).</p></sec><sec><title>Methods</title><p>A pool and split study was carried out comparing untreated and UVC-treated platelets with <30% plasma carryover (n = 10 pairs). This data was compared to components that met specifications (>30% plasma). The platelets were tested over storage for in vitro quality.</p></sec><sec><title>Results</title><p>Platelet metabolism was accelerated following UVC treatment, as demonstrated by increased glucose consumption and lactate production. UVC treatment caused increased externalization of phosphatidylserine on platelets and microparticles, activation of the GPIIb/IIIa receptor (PAC-1 binding), and reduced hypotonic shock response. Platelet function, as measured with thrombelastogram, was not affected by UVC treatment. Components with <30% plasma were similar to those meeting specification with the exception of enhanced glycolytic metabolism.</p></sec><sec><title>Conclusion</title><p>This in vitro analysis demonstrates that treatment of platelets with <30% plasma carryover with the THERAFLEX UV-Platelets system affects some aspects of platelet metabolism and activation, although in vitro platelet function was not negatively impacted. This study also provides evidence that the treatment specifications of plasma carryover could be extended to below 30%.</p></sec></abstract><kwd-group><title>Key Words</title><kwd>UVC</kwd><kwd>Pathogen inactivation</kwd><kwd>Platelet concentrates</kwd><kwd>Plasma carryover</kwd></kwd-group><counts><fig-count count="3"></fig-count><table-count count="4"></table-count><ref-count count="31"></ref-count><page-count count="8"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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