Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">International Myeloma Working Group Recommendations for the Treatment of Multiple Myeloma–Related Bone Disease</title><author><name sortKey="Terpos, Evangelos" sort="Terpos, Evangelos" uniqKey="Terpos E" first="Evangelos" last="Terpos">Evangelos Terpos</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Morgan, Gareth" sort="Morgan, Gareth" uniqKey="Morgan G" first="Gareth" last="Morgan">Gareth Morgan</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Dimopoulos, Meletios A" sort="Dimopoulos, Meletios A" uniqKey="Dimopoulos M" first="Meletios A." last="Dimopoulos">Meletios A. Dimopoulos</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Drake, Matthew T" sort="Drake, Matthew T" uniqKey="Drake M" first="Matthew T." last="Drake">Matthew T. Drake</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Lentzsch, Suzanne" sort="Lentzsch, Suzanne" uniqKey="Lentzsch S" first="Suzanne" last="Lentzsch">Suzanne Lentzsch</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Raje, Noopur" sort="Raje, Noopur" uniqKey="Raje N" first="Noopur" last="Raje">Noopur Raje</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Sezer, Orhan" sort="Sezer, Orhan" uniqKey="Sezer O" first="Orhan" last="Sezer">Orhan Sezer</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Garcia Sanz, Ram N" sort="Garcia Sanz, Ram N" uniqKey="Garcia Sanz R" first="Ram N" last="García-Sanz">Ram N García-Sanz</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Shimizu, Kazuyuki" sort="Shimizu, Kazuyuki" uniqKey="Shimizu K" first="Kazuyuki" last="Shimizu">Kazuyuki Shimizu</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Turesson, Ingemar" sort="Turesson, Ingemar" uniqKey="Turesson I" first="Ingemar" last="Turesson">Ingemar Turesson</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Reiman, Tony" sort="Reiman, Tony" uniqKey="Reiman T" first="Tony" last="Reiman">Tony Reiman</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Jurczyszyn, Artur" sort="Jurczyszyn, Artur" uniqKey="Jurczyszyn A" first="Artur" last="Jurczyszyn">Artur Jurczyszyn</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Merlini, Giampaolo" sort="Merlini, Giampaolo" uniqKey="Merlini G" first="Giampaolo" last="Merlini">Giampaolo Merlini</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Leleu, Xavier" sort="Leleu, Xavier" uniqKey="Leleu X" first="Xavier" last="Leleu">Xavier Leleu</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Cavo, Michele" sort="Cavo, Michele" uniqKey="Cavo M" first="Michele" last="Cavo">Michele Cavo</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Munshi, Nikhil" sort="Munshi, Nikhil" uniqKey="Munshi N" first="Nikhil" last="Munshi">Nikhil Munshi</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Rajkumar, S Vincent" sort="Rajkumar, S Vincent" uniqKey="Rajkumar S" first="S. Vincent" last="Rajkumar">S. Vincent Rajkumar</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Durie, Brian G M" sort="Durie, Brian G M" uniqKey="Durie B" first="Brian G. M." last="Durie">Brian G. M. Durie</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Roodman, G David" sort="Roodman, G David" uniqKey="Roodman G" first="G. David" last="Roodman">G. David Roodman</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23690408</idno><idno type="pmc">4878084</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878084</idno><idno type="RBID">PMC:4878084</idno><idno type="doi">10.1200/JCO.2012.47.7901</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000454</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000454</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">International Myeloma Working Group Recommendations for the Treatment of Multiple Myeloma–Related Bone Disease</title><author><name sortKey="Terpos, Evangelos" sort="Terpos, Evangelos" uniqKey="Terpos E" first="Evangelos" last="Terpos">Evangelos Terpos</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Morgan, Gareth" sort="Morgan, Gareth" uniqKey="Morgan G" first="Gareth" last="Morgan">Gareth Morgan</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Dimopoulos, Meletios A" sort="Dimopoulos, Meletios A" uniqKey="Dimopoulos M" first="Meletios A." last="Dimopoulos">Meletios A. Dimopoulos</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Drake, Matthew T" sort="Drake, Matthew T" uniqKey="Drake M" first="Matthew T." last="Drake">Matthew T. Drake</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Lentzsch, Suzanne" sort="Lentzsch, Suzanne" uniqKey="Lentzsch S" first="Suzanne" last="Lentzsch">Suzanne Lentzsch</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Raje, Noopur" sort="Raje, Noopur" uniqKey="Raje N" first="Noopur" last="Raje">Noopur Raje</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Sezer, Orhan" sort="Sezer, Orhan" uniqKey="Sezer O" first="Orhan" last="Sezer">Orhan Sezer</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Garcia Sanz, Ram N" sort="Garcia Sanz, Ram N" uniqKey="Garcia Sanz R" first="Ram N" last="García-Sanz">Ram N García-Sanz</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Shimizu, Kazuyuki" sort="Shimizu, Kazuyuki" uniqKey="Shimizu K" first="Kazuyuki" last="Shimizu">Kazuyuki Shimizu</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Turesson, Ingemar" sort="Turesson, Ingemar" uniqKey="Turesson I" first="Ingemar" last="Turesson">Ingemar Turesson</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Reiman, Tony" sort="Reiman, Tony" uniqKey="Reiman T" first="Tony" last="Reiman">Tony Reiman</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Jurczyszyn, Artur" sort="Jurczyszyn, Artur" uniqKey="Jurczyszyn A" first="Artur" last="Jurczyszyn">Artur Jurczyszyn</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Merlini, Giampaolo" sort="Merlini, Giampaolo" uniqKey="Merlini G" first="Giampaolo" last="Merlini">Giampaolo Merlini</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Leleu, Xavier" sort="Leleu, Xavier" uniqKey="Leleu X" first="Xavier" last="Leleu">Xavier Leleu</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Cavo, Michele" sort="Cavo, Michele" uniqKey="Cavo M" first="Michele" last="Cavo">Michele Cavo</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Munshi, Nikhil" sort="Munshi, Nikhil" uniqKey="Munshi N" first="Nikhil" last="Munshi">Nikhil Munshi</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Rajkumar, S Vincent" sort="Rajkumar, S Vincent" uniqKey="Rajkumar S" first="S. Vincent" last="Rajkumar">S. Vincent Rajkumar</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Durie, Brian G M" sort="Durie, Brian G M" uniqKey="Durie B" first="Brian G. M." last="Durie">Brian G. M. Durie</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author><author><name sortKey="Roodman, G David" sort="Roodman, G David" uniqKey="Roodman G" first="G. David" last="Roodman">G. David Roodman</name><affiliation><nlm:aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Oncology</title><idno type="ISSN">0732-183X</idno><idno type="eISSN">1527-7755</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>The aim of the International Myeloma Working Group was to develop practice recommendations for the management of multiple myeloma (MM) –related bone disease.</p></sec><sec><title>Methodology</title><p>An interdisciplinary panel of clinical experts on MM and myeloma bone disease developed recommendations based on published data through August 2012. Expert consensus was used to propose additional recommendations in situations where there were insufficient published data. Levels of evidence and grades of recommendations were assigned and approved by panel members.</p></sec><sec><title>Recommendations</title><p>Bisphosphonates (BPs) should be considered in all patients with MM receiving first-line antimyeloma therapy, regardless of presence of osteolytic bone lesions on conventional radiography. However, it is unknown if BPs offer any advantage in patients with no bone disease assessed by magnetic resonance imaging or positron emission tomography/computed tomography. Intravenous (IV) zoledronic acid (ZOL) or pamidronate (PAM) is recommended for preventing skeletal-related events in patients with MM. ZOL is preferred over oral clodronate in newly diagnosed patients with MM because of its potential antimyeloma effects and survival benefits. BPs should be administered every 3 to 4 weeks IV during initial therapy. ZOL or PAM should be continued in patients with active disease and should be resumed after disease relapse, if discontinued in patients achieving complete or very good partial response. BPs are well tolerated, but preventive strategies must be instituted to avoid renal toxicity or osteonecrosis of the jaw. Kyphoplasty should be considered for symptomatic vertebral compression fractures. Low-dose radiation therapy can be used for palliation of uncontrolled pain, impending pathologic fracture, or spinal cord compression. Orthopedic consultation should be sought for long-bone fractures, spinal cord compression, and vertebral column instability.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Oncol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Oncol</journal-id><journal-id journal-id-type="hwp">jco</journal-id><journal-id journal-id-type="pmc">jco</journal-id><journal-id journal-id-type="publisher-id">JCO</journal-id><journal-title-group><journal-title>Journal of Clinical Oncology</journal-title></journal-title-group><issn pub-type="ppub">0732-183X</issn><issn pub-type="epub">1527-7755</issn><publisher><publisher-name>American Society of Clinical Oncology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23690408</article-id><article-id pub-id-type="pmc">4878084</article-id><article-id pub-id-type="publisher-id">X7901</article-id><article-id pub-id-type="doi">10.1200/JCO.2012.47.7901</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>Bone5</subject><subject>Gdln2</subject><subject>Hema20</subject><subject>Hema21</subject><subject>Hema22</subject><subject>Hema23</subject></subj-group><subj-group subj-group-type="heading"><subject>Special Articles</subject></subj-group></article-categories><title-group><article-title>International Myeloma Working Group Recommendations for the Treatment of Multiple Myeloma–Related Bone Disease</article-title><alt-title alt-title-type="short">Multiple Myeloma Bone Disease Treatment Recommendations</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Terpos</surname><given-names>Evangelos</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Morgan</surname><given-names>Gareth</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Dimopoulos</surname><given-names>Meletios A.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Drake</surname><given-names>Matthew T.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Lentzsch</surname><given-names>Suzanne</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Raje</surname><given-names>Noopur</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Sezer</surname><given-names>Orhan</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>García-Sanz</surname><given-names>Ramón</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Shimizu</surname><given-names>Kazuyuki</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Turesson</surname><given-names>Ingemar</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Reiman</surname><given-names>Tony</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Jurczyszyn</surname><given-names>Artur</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Merlini</surname><given-names>Giampaolo</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Spencer</surname><given-names>Andrew</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Leleu</surname><given-names>Xavier</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Cavo</surname><given-names>Michele</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Munshi</surname><given-names>Nikhil</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Rajkumar</surname><given-names>S. Vincent</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Durie</surname><given-names>Brian G.M.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Roodman</surname><given-names>G. David</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><aff id="aff1">Evangelos Terpos and Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Matthew T. Drake and S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Suzanne Lentzsch, Columbia University, New York, NY; Noopur Raje and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA; Orhan Sezer, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ramón García-Sanz, University of Salamanca, Salamanca, Spain; Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan; Ingemar Turesson, Malmo University, Malmo, Sweden; Tony Reiman, University of New Brunswick, Saint John, New Brunswick, Canada; Artur Jurczyszyn, University Hospital, Cracow, Poland; Giampaolo Merlini, University of Pavia, Pavia; Michele Cavo, Bologna University School of Medicine, Bologna, Italy; Andrew Spencer, Monash University, Melbourne, Victoria; Australia; Xavier Leleu, Hopital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France; Brian G.M. Durie, Samuel Oschin Cancer Center, Los Angeles, CA; and G. David Roodman, Indiana University School of Medicine, Indianapolis, IN.</aff></contrib-group><author-notes><corresp id="cor1">Corresponding author: Evangelos Terpos, MD, PhD, Department of Clinical Therapeutics, University of Athens School of Medicine, Alexandra General Hospital, 80 Vas. Sofias Ave, 11528 Athens, Greece; e-mail: <email>eterpos@med.uoa.gr</email>.</corresp></author-notes><pub-date pub-type="ppub"><day>20</day><month>6</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>20</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>20</day><month>5</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>31</volume><issue>18</issue><fpage>2347</fpage><lpage>2357</lpage><permissions><copyright-statement>© 2013 by American Society of Clinical Oncology</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zlj018130W2347.pdf"></self-uri><abstract><sec><title>Purpose</title><p>The aim of the International Myeloma Working Group was to develop practice recommendations for the management of multiple myeloma (MM) –related bone disease.</p></sec><sec><title>Methodology</title><p>An interdisciplinary panel of clinical experts on MM and myeloma bone disease developed recommendations based on published data through August 2012. Expert consensus was used to propose additional recommendations in situations where there were insufficient published data. Levels of evidence and grades of recommendations were assigned and approved by panel members.</p></sec><sec><title>Recommendations</title><p>Bisphosphonates (BPs) should be considered in all patients with MM receiving first-line antimyeloma therapy, regardless of presence of osteolytic bone lesions on conventional radiography. However, it is unknown if BPs offer any advantage in patients with no bone disease assessed by magnetic resonance imaging or positron emission tomography/computed tomography. Intravenous (IV) zoledronic acid (ZOL) or pamidronate (PAM) is recommended for preventing skeletal-related events in patients with MM. ZOL is preferred over oral clodronate in newly diagnosed patients with MM because of its potential antimyeloma effects and survival benefits. BPs should be administered every 3 to 4 weeks IV during initial therapy. ZOL or PAM should be continued in patients with active disease and should be resumed after disease relapse, if discontinued in patients achieving complete or very good partial response. BPs are well tolerated, but preventive strategies must be instituted to avoid renal toxicity or osteonecrosis of the jaw. Kyphoplasty should be considered for symptomatic vertebral compression fractures. Low-dose radiation therapy can be used for palliation of uncontrolled pain, impending pathologic fracture, or spinal cord compression. Orthopedic consultation should be sought for long-bone fractures, spinal cord compression, and vertebral column instability.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 0004549 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 0004549 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |