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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia</title><author><name sortKey="Kantarjian, Hagop M" sort="Kantarjian, Hagop M" uniqKey="Kantarjian H" first="Hagop M." last="Kantarjian">Hagop M. Kantarjian</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Thomas, Xavier G" sort="Thomas, Xavier G" uniqKey="Thomas X" first="Xavier G." last="Thomas">Xavier G. Thomas</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Dmoszynska, Anna" sort="Dmoszynska, Anna" uniqKey="Dmoszynska A" first="Anna" last="Dmoszynska">Anna Dmoszynska</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Wierzbowska, Agnieszka" sort="Wierzbowska, Agnieszka" uniqKey="Wierzbowska A" first="Agnieszka" last="Wierzbowska">Agnieszka Wierzbowska</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Mazur, Grzegorz" sort="Mazur, Grzegorz" uniqKey="Mazur G" first="Grzegorz" last="Mazur">Grzegorz Mazur</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Mayer, Jiri" sort="Mayer, Jiri" uniqKey="Mayer J" first="Jiri" last="Mayer">Jiri Mayer</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Gau, Jyh Pyng" sort="Gau, Jyh Pyng" uniqKey="Gau J" first="Jyh-Pyng" last="Gau">Jyh-Pyng Gau</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Chou, Wen Chien" sort="Chou, Wen Chien" uniqKey="Chou W" first="Wen-Chien" last="Chou">Wen-Chien Chou</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Buckstein, Rena" sort="Buckstein, Rena" uniqKey="Buckstein R" first="Rena" last="Buckstein">Rena Buckstein</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Cermak, Jaroslav" sort="Cermak, Jaroslav" uniqKey="Cermak J" first="Jaroslav" last="Cermak">Jaroslav Cermak</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Kuo, Ching Yuan" sort="Kuo, Ching Yuan" uniqKey="Kuo C" first="Ching-Yuan" last="Kuo">Ching-Yuan Kuo</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Oriol, Albert" sort="Oriol, Albert" uniqKey="Oriol A" first="Albert" last="Oriol">Albert Oriol</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Ravandi, Farhad" sort="Ravandi, Farhad" uniqKey="Ravandi F" first="Farhad" last="Ravandi">Farhad Ravandi</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Faderl, Stefan" sort="Faderl, Stefan" uniqKey="Faderl S" first="Stefan" last="Faderl">Stefan Faderl</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Delaunay, Jacques" sort="Delaunay, Jacques" uniqKey="Delaunay J" first="Jacques" last="Delaunay">Jacques Delaunay</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Lysak, Daniel" sort="Lysak, Daniel" uniqKey="Lysak D" first="Daniel" last="Lysák">Daniel Lysák</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Minden, Mark" sort="Minden, Mark" uniqKey="Minden M" first="Mark" last="Minden">Mark Minden</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Arthur, Christopher" sort="Arthur, Christopher" uniqKey="Arthur C" first="Christopher" last="Arthur">Christopher Arthur</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22689805</idno><idno type="pmc">4874148</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874148</idno><idno type="RBID">PMC:4874148</idno><idno type="doi">10.1200/JCO.2011.38.9429</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000451</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000451</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia</title><author><name sortKey="Kantarjian, Hagop M" sort="Kantarjian, Hagop M" uniqKey="Kantarjian H" first="Hagop M." last="Kantarjian">Hagop M. Kantarjian</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Thomas, Xavier G" sort="Thomas, Xavier G" uniqKey="Thomas X" first="Xavier G." last="Thomas">Xavier G. Thomas</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Dmoszynska, Anna" sort="Dmoszynska, Anna" uniqKey="Dmoszynska A" first="Anna" last="Dmoszynska">Anna Dmoszynska</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Wierzbowska, Agnieszka" sort="Wierzbowska, Agnieszka" uniqKey="Wierzbowska A" first="Agnieszka" last="Wierzbowska">Agnieszka Wierzbowska</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Mazur, Grzegorz" sort="Mazur, Grzegorz" uniqKey="Mazur G" first="Grzegorz" last="Mazur">Grzegorz Mazur</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Mayer, Jiri" sort="Mayer, Jiri" uniqKey="Mayer J" first="Jiri" last="Mayer">Jiri Mayer</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Gau, Jyh Pyng" sort="Gau, Jyh Pyng" uniqKey="Gau J" first="Jyh-Pyng" last="Gau">Jyh-Pyng Gau</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Chou, Wen Chien" sort="Chou, Wen Chien" uniqKey="Chou W" first="Wen-Chien" last="Chou">Wen-Chien Chou</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Buckstein, Rena" sort="Buckstein, Rena" uniqKey="Buckstein R" first="Rena" last="Buckstein">Rena Buckstein</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Cermak, Jaroslav" sort="Cermak, Jaroslav" uniqKey="Cermak J" first="Jaroslav" last="Cermak">Jaroslav Cermak</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Kuo, Ching Yuan" sort="Kuo, Ching Yuan" uniqKey="Kuo C" first="Ching-Yuan" last="Kuo">Ching-Yuan Kuo</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Oriol, Albert" sort="Oriol, Albert" uniqKey="Oriol A" first="Albert" last="Oriol">Albert Oriol</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Ravandi, Farhad" sort="Ravandi, Farhad" uniqKey="Ravandi F" first="Farhad" last="Ravandi">Farhad Ravandi</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Faderl, Stefan" sort="Faderl, Stefan" uniqKey="Faderl S" first="Stefan" last="Faderl">Stefan Faderl</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Delaunay, Jacques" sort="Delaunay, Jacques" uniqKey="Delaunay J" first="Jacques" last="Delaunay">Jacques Delaunay</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Lysak, Daniel" sort="Lysak, Daniel" uniqKey="Lysak D" first="Daniel" last="Lysák">Daniel Lysák</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Minden, Mark" sort="Minden, Mark" uniqKey="Minden M" first="Mark" last="Minden">Mark Minden</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author><author><name sortKey="Arthur, Christopher" sort="Arthur, Christopher" uniqKey="Arthur C" first="Christopher" last="Arthur">Christopher Arthur</name><affiliation><nlm:aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Oncology</title><idno type="ISSN">0732-183X</idno><idno type="eISSN">1527-7755</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>This multicenter, randomized, open-label, phase III trial compared the efficacy and safety of decitabine with treatment choice (TC) in older patients with newly diagnosed acute myeloid leukemia (AML) and poor- or intermediate-risk cytogenetics.</p></sec><sec><title>Patients and Methods</title><p>Patients (N = 485) age ≥ 65 years were randomly assigned 1:1 to receive decitabine 20 mg/m<sup>2</sup> per day as a 1-hour intravenous infusion for five consecutive days every 4 weeks or TC (supportive care or cytarabine 20 mg/m<sup>2</sup> per day as a subcutaneous injection for 10 consecutive days every 4 weeks). The primary end point was overall survival (OS); the secondary end point was the complete remission (CR) rate plus the CR rate without platelet recovery (CRp). Adverse events (AEs) were recorded.</p></sec><sec><title>Results</title><p>The primary analysis with 396 deaths (81.6%) showed a nonsignificant increase in median OS with decitabine (7.7 months; 95% CI, 6.2 to 9.2) versus TC (5.0 months; 95% CI, 4.3 to 6.3; <italic>P</italic> = .108; hazard ratio [HR], 0.85; 95% CI, 0.69 to 1.04). An unplanned analysis with 446 deaths (92%) indicated the same median OS (HR, 0.82; 95% CI, 0.68 to 0.99; nominal <italic>P</italic> = .037). The CR rate plus CRp was 17.8% with decitabine versus 7.8% with TC (odds ratio, 2.5; 95% CI, 1.4 to 4.8; <italic>P</italic> = .001). AEs were similar for decitabine and cytarabine, although patients received a median of four cycles of decitabine versus two cycles of TC. The most common drug-related AEs with decitabine were thrombocytopenia (27%) and neutropenia (24%).</p></sec><sec><title>Conclusion</title><p>In older patients with AML, decitabine improved response rates compared with standard therapies without major differences in safety. An unplanned survival analysis showed a benefit for decitabine, which was not observed at the time of the primary analysis.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Oncol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Oncol</journal-id><journal-id journal-id-type="hwp">jco</journal-id><journal-id journal-id-type="pmc">jco</journal-id><journal-id journal-id-type="publisher-id">JCO</journal-id><journal-title-group><journal-title>Journal of Clinical Oncology</journal-title></journal-title-group><issn pub-type="ppub">0732-183X</issn><issn pub-type="epub">1527-7755</issn><publisher><publisher-name>American Society of Clinical Oncology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22689805</article-id><article-id pub-id-type="pmc">4874148</article-id><article-id pub-id-type="publisher-id">89429</article-id><article-id pub-id-type="doi">10.1200/JCO.2011.38.9429</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>Hema13</subject></subj-group><subj-group subj-group-type="heading"><subject>ORIGINAL REPORTS</subject><subj-group><subject>Hematologic Malignancy</subject></subj-group></subj-group></article-categories><title-group><article-title>Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia</article-title><alt-title alt-title-type="short">Decitabine <italic>v</italic> Supportive Care or Cytarabine in Older Patients With AML</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kantarjian</surname><given-names>Hagop M.</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Thomas</surname><given-names>Xavier G.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Dmoszynska</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Wierzbowska</surname><given-names>Agnieszka</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Mazur</surname><given-names>Grzegorz</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Mayer</surname><given-names>Jiri</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Gau</surname><given-names>Jyh-Pyng</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Chou</surname><given-names>Wen-Chien</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Buckstein</surname><given-names>Rena</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Cermak</surname><given-names>Jaroslav</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Kuo</surname><given-names>Ching-Yuan</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Oriol</surname><given-names>Albert</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Ravandi</surname><given-names>Farhad</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Faderl</surname><given-names>Stefan</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Delaunay</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Lysák</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Minden</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Arthur</surname><given-names>Christopher</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><aff id="aff1">Hagop M. Kantarjian, Farhad Ravandi, and Stefan Faderl, University of Texas MD Anderson Cancer Center, Houston, TX; Xavier. G. Thomas, Hôpital Edouard Herriot, Lyon, France; Anna Dmoszynska, Medical University of Lublin, Lublin; Agnieszka Wierzbowska, Medical University of Lodz, Lodz; Grzegorz Mazur, Wroclaw Medical University, Wroclaw, Poland; Jiri Mayer, University Hospital Brno; Jiri Mayer, Central European Institute of Technology, Masaryk University, Brno; Daniel Lysák, University Hospital Plzeň, Plzeň; Jaroslav Cermak, Charles University, Prague, Czech Republic; Jyh-Pyng Gau, Taipei Veterans General Hospital; Wen-Chien Chou, National Taiwan University Hospital, Taipei; Ching-Yuan Kuo, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rena Buckstein, Odette Cancer Centre; Mark Minden, University of Toronto, Toronto, Canada; Albert Oriol, Hospital Universitari Germans Trias i Pujol, Catalunya, Spain; Jacques Delaunay, Nantes University Hospital, Nantes, France; and Christopher Arthur, Royal North Shore Hospital, St Leonards, New South Wales, Australia.</aff></contrib-group><author-notes><corresp id="cor1">Corresponding author: Hagop M. Kantarjian, MD, Department of Leukemia, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; e-mail: <email>hkantarj@mdanderson.org</email>.</corresp></author-notes><pub-date pub-type="ppub"><day>20</day><month>7</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>11</day><month>6</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>6</month><year>2012</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>30</volume><issue>21</issue><fpage>2670</fpage><lpage>2677</lpage><history><date date-type="received"><day>17</day><month>8</month><year>2011</year></date><date date-type="accepted"><day>1</day><month>3</month><year>2012</year></date></history><permissions><copyright-statement>© 2012 by American Society of Clinical Oncology</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zlj02112002670.pdf"></self-uri><abstract><sec><title>Purpose</title><p>This multicenter, randomized, open-label, phase III trial compared the efficacy and safety of decitabine with treatment choice (TC) in older patients with newly diagnosed acute myeloid leukemia (AML) and poor- or intermediate-risk cytogenetics.</p></sec><sec><title>Patients and Methods</title><p>Patients (N = 485) age ≥ 65 years were randomly assigned 1:1 to receive decitabine 20 mg/m<sup>2</sup> per day as a 1-hour intravenous infusion for five consecutive days every 4 weeks or TC (supportive care or cytarabine 20 mg/m<sup>2</sup> per day as a subcutaneous injection for 10 consecutive days every 4 weeks). The primary end point was overall survival (OS); the secondary end point was the complete remission (CR) rate plus the CR rate without platelet recovery (CRp). Adverse events (AEs) were recorded.</p></sec><sec><title>Results</title><p>The primary analysis with 396 deaths (81.6%) showed a nonsignificant increase in median OS with decitabine (7.7 months; 95% CI, 6.2 to 9.2) versus TC (5.0 months; 95% CI, 4.3 to 6.3; <italic>P</italic> = .108; hazard ratio [HR], 0.85; 95% CI, 0.69 to 1.04). An unplanned analysis with 446 deaths (92%) indicated the same median OS (HR, 0.82; 95% CI, 0.68 to 0.99; nominal <italic>P</italic> = .037). The CR rate plus CRp was 17.8% with decitabine versus 7.8% with TC (odds ratio, 2.5; 95% CI, 1.4 to 4.8; <italic>P</italic> = .001). AEs were similar for decitabine and cytarabine, although patients received a median of four cycles of decitabine versus two cycles of TC. The most common drug-related AEs with decitabine were thrombocytopenia (27%) and neutropenia (24%).</p></sec><sec><title>Conclusion</title><p>In older patients with AML, decitabine improved response rates compared with standard therapies without major differences in safety. An unplanned survival analysis showed a benefit for decitabine, which was not observed at the time of the primary analysis.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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