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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index</title><author><name sortKey="Felix, Janine F" sort="Felix, Janine F" uniqKey="Felix J" first="Janine F." last="Felix">Janine F. Felix</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Pediatrics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P." last="Bradfield">Jonathan P. Bradfield</name><affiliation><nlm:aff id="af5"><addr-line>Center for Applied Genomics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Monnereau, Claire" sort="Monnereau, Claire" uniqKey="Monnereau C" first="Claire" last="Monnereau">Claire Monnereau</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Pediatrics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Van Der Valk, Ralf J P" sort="Van Der Valk, Ralf J P" uniqKey="Van Der Valk R" first="Ralf J. P." last="Van Der Valk">Ralf J. P. Van Der Valk</name><affiliation><nlm:aff id="af9"><addr-line>Department of Pulmonology, GRIAC (Groningen Research Institute for Asthma and COPD)</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Stergiakouli, Evie" sort="Stergiakouli, Evie" uniqKey="Stergiakouli E" first="Evie" last="Stergiakouli">Evie Stergiakouli</name><affiliation><nlm:aff id="af12"><addr-line>MRC Integrative Epidemiology Unit at the University of Bristol</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chesi, Alessandra" sort="Chesi, Alessandra" uniqKey="Chesi A" first="Alessandra" last="Chesi">Alessandra Chesi</name><affiliation><nlm:aff id="af6"><addr-line>Division of Human Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Gaillard, Romy" sort="Gaillard, Romy" uniqKey="Gaillard R" first="Romy" last="Gaillard">Romy Gaillard</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Pediatrics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Feenstra, Bjarke" sort="Feenstra, Bjarke" uniqKey="Feenstra B" first="Bjarke" last="Feenstra">Bjarke Feenstra</name><affiliation><nlm:aff id="af14"><addr-line>Department of Epidemiology Research</addr-line>,<institution>Statens Serum Institut</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name><affiliation><nlm:aff id="af15"><institution>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af16"><addr-line>Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital</addr-line>,<institution>University of Munich Medical Center</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Kreiner M Ller, Eskil" sort="Kreiner M Ller, Eskil" uniqKey="Kreiner M Ller E" first="Eskil" last="Kreiner-M Ller">Eskil Kreiner-M Ller</name><affiliation><nlm:aff id="af44"><addr-line>COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mahajan, Anubha" sort="Mahajan, Anubha" uniqKey="Mahajan A" first="Anubha" last="Mahajan">Anubha Mahajan</name><affiliation><nlm:aff id="af18"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Pitk Nen, Niina" sort="Pitk Nen, Niina" uniqKey="Pitk Nen N" first="Niina" last="Pitk Nen">Niina Pitk Nen</name><affiliation><nlm:aff id="af20"><addr-line>Research Centre of Applied and Preventive Cardiovascular Medicine</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af24"><addr-line>Institute of Clinical Medicine, Neurology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Joro, Raimo" sort="Joro, Raimo" uniqKey="Joro R" first="Raimo" last="Joro">Raimo Joro</name><affiliation><nlm:aff id="af25"><addr-line>Institute of Biomedicine, Physiology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Cavadino, Alana" sort="Cavadino, Alana" uniqKey="Cavadino A" first="Alana" last="Cavadino">Alana Cavadino</name><affiliation><nlm:aff id="af26"><addr-line>Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry</addr-line>,<institution>Queen Mary University of London</institution>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af27"><addr-line>Population, Policy and Practice, UCL Institute of Child Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Huikari, Ville" sort="Huikari, Ville" uniqKey="Huikari V" first="Ville" last="Huikari">Ville Huikari</name><affiliation><nlm:aff id="af29"><addr-line>Centre for Life Course Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Franks, Steve" sort="Franks, Steve" uniqKey="Franks S" first="Steve" last="Franks">Steve Franks</name><affiliation><nlm:aff id="af32"><addr-line>Institute of Reproductive and Developmental Biology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Groen Blokhuis, Maria M" sort="Groen Blokhuis, Maria M" uniqKey="Groen Blokhuis M" first="Maria M." last="Groen-Blokhuis">Maria M. Groen-Blokhuis</name><affiliation><nlm:aff id="af34"><addr-line>Department of Biological Psychology</addr-line>,<institution>VU University Amsterdam</institution>,<institution>NCA Neuroscience Campus Amsterdam</institution>,<institution>EMGO+ Institute for Health and Care Research</institution>,<addr-line>Amsterdam</addr-line>,<country>the Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L." last="Cousminer">Diana L. Cousminer</name><affiliation><nlm:aff id="af35"><addr-line>Institute for Molecular Medicine, Finland (FIMM)</addr-line>,<institution>University of Helsinki</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Marsh, Julie A" sort="Marsh, Julie A" uniqKey="Marsh J" first="Julie A." last="Marsh">Julie A. Marsh</name><affiliation><nlm:aff id="af36"><addr-line>School of Women's and Infants’ Health</addr-line>,<institution>The University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="af37"><addr-line>Department of Clinical Chemistry</addr-line>,<institution>Fimlab Laboratories</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af38"><addr-line>Department of Clinical Chemistry</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Curtin, John A" sort="Curtin, John A" uniqKey="Curtin J" first="John A." last="Curtin">John A. Curtin</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair</addr-line>,<institution>University of Manchester</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af41"><institution>University Hospital of South Manchester, Manchester Academic Health Sciences Centre</institution>,<addr-line>Manchester</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Vioque, Jesus" sort="Vioque, Jesus" uniqKey="Vioque J" first="Jesus" last="Vioque">Jesus Vioque</name><affiliation><nlm:aff id="af42"><institution>Universidad Miguel Hernandez</institution>,<addr-line>Elche-Alicante</addr-line>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af43"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Ahluwalia, Tarunveer S" sort="Ahluwalia, Tarunveer S" uniqKey="Ahluwalia T" first="Tarunveer S." last="Ahluwalia">Tarunveer S. Ahluwalia</name><affiliation><nlm:aff id="af44"><addr-line>COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af45"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af46"><institution>Steno Diabetes Center</institution>,<addr-line>Gentofte</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Myhre, Ronny" sort="Myhre, Ronny" uniqKey="Myhre R" first="Ronny" last="Myhre">Ronny Myhre</name><affiliation><nlm:aff id="af47"><addr-line>Department of Genes and Envrionment, Division of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Price, Thomas S" sort="Price, Thomas S" uniqKey="Price T" first="Thomas S." last="Price">Thomas S. Price</name><affiliation><nlm:aff id="af49"><addr-line>Department of Systems Pharmacology and Translational Therapeutics</addr-line>,<institution>University of Pennsylvania Perelman School of Medicine</institution>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Vilor Tejedor, Natalia" sort="Vilor Tejedor, Natalia" uniqKey="Vilor Tejedor N" first="Natalia" last="Vilor-Tejedor">Natalia Vilor-Tejedor</name><affiliation><nlm:aff id="af43"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>Centre for Research in Environmental Epidemiology (CREAL)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af51"><institution>Pompeu Fabra University (UPF)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loïc" last="Yengo">Loïc Yengo</name><affiliation><nlm:aff id="af52"><institution>CNRS UMR8199, Pasteur Institute Lille</institution>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af53"><institution>European Genomic Institute for Diabetes (EGID)</institution>,<addr-line>Lille</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Grarup, Niels" sort="Grarup, Niels" uniqKey="Grarup N" first="Niels" last="Grarup">Niels Grarup</name><affiliation><nlm:aff id="af45"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Ntalla, Ioanna" sort="Ntalla, Ioanna" uniqKey="Ntalla I" first="Ioanna" last="Ntalla">Ioanna Ntalla</name><affiliation><nlm:aff id="af54"><addr-line>Department of Health Sciences</addr-line>,<institution>University of Leicester</institution>,<addr-line>Leicester</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af55"><addr-line>Department of Nutrition and Dietetics, School of Health Science and Education</addr-line>,<institution>Harokopio University</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Ang, Wei" sort="Ang, Wei" uniqKey="Ang W" first="Wei" last="Ang">Wei Ang</name><affiliation><nlm:aff id="af36"><addr-line>School of Women's and Infants’ Health</addr-line>,<institution>The University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Atalay, Mustafa" sort="Atalay, Mustafa" uniqKey="Atalay M" first="Mustafa" last="Atalay">Mustafa Atalay</name><affiliation><nlm:aff id="af25"><addr-line>Institute of Biomedicine, Physiology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name><affiliation><nlm:aff id="af44"><addr-line>COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Blakemore, Alexandra I" sort="Blakemore, Alexandra I" uniqKey="Blakemore A" first="Alexandra I." last="Blakemore">Alexandra I. Blakemore</name><affiliation><nlm:aff id="af33"><addr-line>Section of Investigative Medicine, Division of Diabetes, Endocrinology, and Metabolism, Faculty of Medicine</addr-line>,<institution>Imperial College</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Bonnefond, Amelie" sort="Bonnefond, Amelie" uniqKey="Bonnefond A" first="Amelie" last="Bonnefond">Amelie Bonnefond</name><affiliation><nlm:aff id="af52"><institution>CNRS UMR8199, Pasteur Institute Lille</institution>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af53"><institution>European Genomic Institute for Diabetes (EGID)</institution>,<addr-line>Lille</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Carstensen, Lisbeth" sort="Carstensen, Lisbeth" uniqKey="Carstensen L" first="Lisbeth" last="Carstensen">Lisbeth Carstensen</name><affiliation><nlm:aff id="af14"><addr-line>Department of Epidemiology Research</addr-line>,<institution>Statens Serum Institut</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name><affiliation><nlm:aff id="af56"><institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Flexeder, Claudia" sort="Flexeder, Claudia" uniqKey="Flexeder C" first="Claudia" last="Flexeder">Claudia Flexeder</name><affiliation><nlm:aff id="af15"><institution>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation><nlm:aff id="af10"><addr-line>Department of Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name><affiliation><nlm:aff id="af14"><addr-line>Department of Epidemiology Research</addr-line>,<institution>Statens Serum Institut</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Geserick, Mandy" sort="Geserick, Mandy" uniqKey="Geserick M" first="Mandy" last="Geserick">Mandy Geserick</name><affiliation><nlm:aff id="af57"><addr-line>Center of Pediatric Research, Department of Women’s and Child Health</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af58"><addr-line>LIFE Child (Leipzig Research Center for Civilization Diseases)</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="af30"><addr-line>Institute of Clinical Medicine/Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Haworth, Claire M A" sort="Haworth, Claire M A" uniqKey="Haworth C" first="Claire M. A." last="Haworth">Claire M. A. Haworth</name><affiliation><nlm:aff id="af60"><addr-line>Department of Psychology</addr-line>,<institution>University of Warwick</institution>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><nlm:aff id="af61"><addr-line>Division of Endocrinology and Center for Basic and Translational Obesity Research</addr-line>,<institution>Boston Children's Hospital</institution>,<addr-line>Boston</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af62"><addr-line>Medical and Population Genetics Program</addr-line>,<institution>Broad Institute of MIT and Harvard</institution>,<addr-line>Cambridge</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Department of Genetics</addr-line>,<institution>Harvard Medical School</institution>,<addr-line>Boston</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Holm, Jens Christian" sort="Holm, Jens Christian" uniqKey="Holm J" first="Jens-Christian" last="Holm">Jens-Christian Holm</name><affiliation><nlm:aff id="af64"><addr-line>The Children's Obesity Clinic, Department of Pediatrics</addr-line>,<institution>Copenhagen University Hospital Holbæk, The Danish Childhood Obesity Biobank</institution>,<country>Denmark</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Institute of Medicine, Copenhagen University,</institution><addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Horikoshi, Momoko" sort="Horikoshi, Momoko" uniqKey="Horikoshi M" first="Momoko" last="Horikoshi">Momoko Horikoshi</name><affiliation><nlm:aff id="af18"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af19"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke Jan" last="Hottenga">Jouke Jan Hottenga</name><affiliation><nlm:aff id="af34"><addr-line>Department of Biological Psychology</addr-line>,<institution>VU University Amsterdam</institution>,<institution>NCA Neuroscience Campus Amsterdam</institution>,<institution>EMGO+ Institute for Health and Care Research</institution>,<addr-line>Amsterdam</addr-line>,<country>the Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Huang, Jinyan" sort="Huang, Jinyan" uniqKey="Huang J" first="Jinyan" last="Huang">Jinyan Huang</name><affiliation><nlm:aff id="af66"><addr-line>State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology</addr-line>,<institution>Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</nlm:aff></affiliation></author><author><name sortKey="Kadarmideen, Haja N" sort="Kadarmideen, Haja N" uniqKey="Kadarmideen H" first="Haja N." last="Kadarmideen">Haja N. Kadarmideen</name><affiliation><nlm:aff id="af67"><addr-line>Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Frederiksberg C</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="af39"><addr-line>Department of Clinical Physiology</addr-line>,<institution>University of Tampere School of Medicine</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af68"><addr-line>Department of Clinical Physiology</addr-line>,<institution>Tampere University Hospital</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Kiess, Wieland" sort="Kiess, Wieland" uniqKey="Kiess W" first="Wieland" last="Kiess">Wieland Kiess</name><affiliation><nlm:aff id="af57"><addr-line>Center of Pediatric Research, Department of Women’s and Child Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lakka, Hanna Maaria" sort="Lakka, Hanna Maaria" uniqKey="Lakka H" first="Hanna-Maaria" last="Lakka">Hanna-Maaria Lakka</name><affiliation><nlm:aff id="af25"><addr-line>Institute of Biomedicine, Physiology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Lakka, Timo A" sort="Lakka, Timo A" uniqKey="Lakka T" first="Timo A." last="Lakka">Timo A. Lakka</name><affiliation><nlm:aff id="af25"><addr-line>Institute of Biomedicine, Physiology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af69"><institution>Kuopio Research Institute of Exercise Medicine</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af70"><addr-line>Department of Clinical Physiology and Nuclear Medicine</addr-line>,<institution>Kuopio University Hospital</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Lewin, Alexandra M" sort="Lewin, Alexandra M" uniqKey="Lewin A" first="Alexandra M." last="Lewin">Alexandra M. Lewin</name><affiliation><nlm:aff id="af71"><addr-line>Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="af72"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af73"><addr-line>Department of Biostatistics</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation><nlm:aff id="af37"><addr-line>Department of Clinical Chemistry</addr-line>,<institution>Fimlab Laboratories</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af38"><addr-line>Department of Clinical Chemistry</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ma, Baoshan" sort="Ma, Baoshan" uniqKey="Ma B" first="Baoshan" last="Ma">Baoshan Ma</name><affiliation><nlm:aff id="af74"><addr-line>College of Information Science and Technology</addr-line>,<institution>Dalian Maritime University</institution>,<addr-line>Dalian, Liaoning Province</addr-line>,<country>China</country>,</nlm:aff></affiliation></author><author><name sortKey="Magnus, Per" sort="Magnus, Per" uniqKey="Magnus P" first="Per" last="Magnus">Per Magnus</name><affiliation><nlm:aff id="af48"><addr-line>Division of Epidemiology</addr-line>,<institution>Norwegian Institute of Public Health</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</nlm:aff></affiliation></author><author><name sortKey="Mccormack, Shana E" sort="Mccormack, Shana E" uniqKey="Mccormack S" first="Shana E." last="Mccormack">Shana E. Mccormack</name><affiliation><nlm:aff id="af6"><addr-line>Division of Human Genetics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af7"><addr-line>Division of Endocrinology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af75"><addr-line>Department of Pediatrics, Perelman School of Medicine</addr-line>,<institution>University of Pennsylvania</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name><affiliation><nlm:aff id="af12"><addr-line>MRC Integrative Epidemiology Unit at the University of Bristol</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mentch, Frank D" sort="Mentch, Frank D" uniqKey="Mentch F" first="Frank D." last="Mentch">Frank D. Mentch</name><affiliation><nlm:aff id="af5"><addr-line>Center for Applied Genomics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Middeldorp, Christel M" sort="Middeldorp, Christel M" uniqKey="Middeldorp C" first="Christel M." last="Middeldorp">Christel M. Middeldorp</name><affiliation><nlm:aff id="af34"><addr-line>Department of Biological Psychology</addr-line>,<institution>VU University Amsterdam</institution>,<institution>NCA Neuroscience Campus Amsterdam</institution>,<institution>EMGO+ Institute for Health and Care Research</institution>,<addr-line>Amsterdam</addr-line>,<country>the Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Murray, Clare S" sort="Murray, Clare S" uniqKey="Murray C" first="Clare S." last="Murray">Clare S. Murray</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair</addr-line>,<institution>University of Manchester</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af41"><institution>University Hospital of South Manchester, Manchester Academic Health Sciences Centre</institution>,<addr-line>Manchester</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Pahkala, Katja" sort="Pahkala, Katja" uniqKey="Pahkala K" first="Katja" last="Pahkala">Katja Pahkala</name><affiliation><nlm:aff id="af20"><addr-line>Research Centre of Applied and Preventive Cardiovascular Medicine</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af21"><addr-line>Department of Health and Physical Activity, Paavo Nurmi Centre, Sports and Exercise Medicine Unit</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Pers, Tune H" sort="Pers, Tune H" uniqKey="Pers T" first="Tune H." last="Pers">Tune H. Pers</name><affiliation><nlm:aff id="af61"><addr-line>Division of Endocrinology and Center for Basic and Translational Obesity Research</addr-line>,<institution>Boston Children's Hospital</institution>,<addr-line>Boston</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af62"><addr-line>Medical and Population Genetics Program</addr-line>,<institution>Broad Institute of MIT and Harvard</institution>,<addr-line>Cambridge</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Pf Ffle, Roland" sort="Pf Ffle, Roland" uniqKey="Pf Ffle R" first="Roland" last="Pf Ffle">Roland Pf Ffle</name><affiliation><nlm:aff id="af57"><addr-line>Center of Pediatric Research, Department of Women’s and Child Health</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af59"><addr-line>CrescNet, Medical Faculty</addr-line>,<institution>University of Leipzig</institution>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name><affiliation><nlm:aff id="af9"><addr-line>Department of Pulmonology, GRIAC (Groningen Research Institute for Asthma and COPD)</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Power, Christine" sort="Power, Christine" uniqKey="Power C" first="Christine" last="Power">Christine Power</name><affiliation><nlm:aff id="af27"><addr-line>Population, Policy and Practice, UCL Institute of Child Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Simpson, Angela" sort="Simpson, Angela" uniqKey="Simpson A" first="Angela" last="Simpson">Angela Simpson</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair</addr-line>,<institution>University of Manchester</institution></nlm:aff></affiliation></author><author><name sortKey="Sengpiel, Verena" sort="Sengpiel, Verena" uniqKey="Sengpiel V" first="Verena" last="Sengpiel">Verena Sengpiel</name><affiliation><nlm:aff id="af76"><addr-line>Department of Obstetrics and Gynecology, Sahlgrenska Academy</addr-line>,<institution>Sahlgrenska University Hosptial</institution>,<addr-line>Gothenburg</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Tiesler, Carla M T" sort="Tiesler, Carla M T" uniqKey="Tiesler C" first="Carla M. T." last="Tiesler">Carla M. T. Tiesler</name><affiliation><nlm:aff id="af15"><institution>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af16"><addr-line>Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital</addr-line>,<institution>University of Munich Medical Center</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Torrent, Maties" sort="Torrent, Maties" uniqKey="Torrent M" first="Maties" last="Torrent">Maties Torrent</name><affiliation><nlm:aff id="af43"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af77"><institution>Area de Salut de Menorca, ib-salut</institution>,<addr-line>Menorca</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Department of Internal Medicine</addr-line>,<institution>Erasmus MC, University Medical Center Rotterdam</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Van Meurs, Joyce B" sort="Van Meurs, Joyce B" uniqKey="Van Meurs J" first="Joyce B." last="Van Meurs">Joyce B. Van Meurs</name><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Department of Internal Medicine</addr-line>,<institution>Erasmus MC, University Medical Center Rotterdam</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Vinding, Rebecca" sort="Vinding, Rebecca" uniqKey="Vinding R" first="Rebecca" last="Vinding">Rebecca Vinding</name><affiliation><nlm:aff id="af17"><addr-line>Department of Pediatrics, Naestved Hospital, Naestved, Denmark</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af44"><addr-line>COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Waage, Johannes" sort="Waage, Johannes" uniqKey="Waage J" first="Johannes" last="Waage">Johannes Waage</name><affiliation><nlm:aff id="af44"><addr-line>COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Wardle, Jane" sort="Wardle, Jane" uniqKey="Wardle J" first="Jane" last="Wardle">Jane Wardle</name><affiliation><nlm:aff id="af28"><addr-line>Department of Epidemiology and Public Health</addr-line>,<institution>University College London</institution>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Zeggini, Eleftheria" sort="Zeggini, Eleftheria" uniqKey="Zeggini E" first="Eleftheria" last="Zeggini">Eleftheria Zeggini</name><affiliation><nlm:aff id="af78"><institution>Wellcome Trust Sanger Institute, The Morgan Building, Wellcome Trust Genome Campus</institution>,<addr-line>Hinxton, Cambridgeshire</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Zemel, Babette S" sort="Zemel, Babette S" uniqKey="Zemel B" first="Babette S." last="Zemel">Babette S. Zemel</name><affiliation><nlm:aff id="af8"><addr-line>Division of Gastroenterology, Hepatology and Nutrition</addr-line>,<institution>The Children's Hospital of Philadelphia</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af75"><addr-line>Department of Pediatrics, Perelman School of Medicine</addr-line>,<institution>University of Pennsylvania</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V." last="Dedoussis">George V. Dedoussis</name><affiliation><nlm:aff id="af55"><addr-line>Department of Nutrition and Dietetics, School of Health Science and Education</addr-line>,<institution>Harokopio University</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Oluf" sort="Pedersen, Oluf" uniqKey="Pedersen O" first="Oluf" last="Pedersen">Oluf Pedersen</name><affiliation><nlm:aff id="af45"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="af52"><institution>CNRS UMR8199, Pasteur Institute Lille</institution>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af79"><addr-line>Department of Genomics of Common Disease</addr-line>,<institution>School of Public Health, Imperial College London, Hammersmith Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name><affiliation><nlm:aff id="af43"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>Centre for Research in Environmental Epidemiology (CREAL)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af51"><institution>Pompeu Fabra University (UPF)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af80"><institution>IMIM (Hospital del Mar Medical Research Institute)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Plomin, Robert" sort="Plomin, Robert" uniqKey="Plomin R" first="Robert" last="Plomin">Robert Plomin</name><affiliation><nlm:aff id="af81"><addr-line>King's College London, MRC Social, Genetic and Developmental Psychiatry Centre</addr-line>,<institution>Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Jacobsson, Bo" sort="Jacobsson, Bo" uniqKey="Jacobsson B" first="Bo" last="Jacobsson">Bo Jacobsson</name><affiliation><nlm:aff id="af47"><addr-line>Department of Genes and Envrionment, Division of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af76"><addr-line>Department of Obstetrics and Gynecology, Sahlgrenska Academy</addr-line>,<institution>Sahlgrenska University Hosptial</institution>,<addr-line>Gothenburg</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation><nlm:aff id="af45"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Gonzalez, Juan R" sort="Gonzalez, Juan R" uniqKey="Gonzalez J" first="Juan R." last="Gonzalez">Juan R. Gonzalez</name><affiliation><nlm:aff id="af43"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>Centre for Research in Environmental Epidemiology (CREAL)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af51"><institution>Pompeu Fabra University (UPF)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Custovic, Adnan" sort="Custovic, Adnan" uniqKey="Custovic A" first="Adnan" last="Custovic">Adnan Custovic</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair</addr-line>,<institution>University of Manchester</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af41"><institution>University Hospital of South Manchester, Manchester Academic Health Sciences Centre</institution>,<addr-line>Manchester</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><affiliation><nlm:aff id="af20"><addr-line>Research Centre of Applied and Preventive Cardiovascular Medicine</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af22"><addr-line>Department of Clinical Physiology and Nuclear Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name><affiliation><nlm:aff id="af36"><addr-line>School of Women's and Infants’ Health</addr-line>,<institution>The University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widén">Elisabeth Widén</name><affiliation><nlm:aff id="af35"><addr-line>Institute for Molecular Medicine, Finland (FIMM)</addr-line>,<institution>University of Helsinki</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="af34"><addr-line>Department of Biological Psychology</addr-line>,<institution>VU University Amsterdam</institution>,<institution>NCA Neuroscience Campus Amsterdam</institution>,<institution>EMGO+ Institute for Health and Care Research</institution>,<addr-line>Amsterdam</addr-line>,<country>the Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name><affiliation><nlm:aff id="af11"><addr-line>Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC (Groningen Research Institute for Asthma and COPD)</addr-line>,<institution>University of Groningen, University Medical Center Groningen</institution>,<addr-line>Groningen</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Sebert, Sylvain" sort="Sebert, Sylvain" uniqKey="Sebert S" first="Sylvain" last="Sebert">Sylvain Sebert</name><affiliation><nlm:aff id="af29"><addr-line>Centre for Life Course Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af31"><addr-line>Biocenter Oulu</addr-line>,<institution>University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation><nlm:aff id="af29"><addr-line>Centre for Life Course Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af31"><addr-line>Biocenter Oulu</addr-line>,<institution>University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af71"><addr-line>Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af82"><addr-line>Unit of Primary Care</addr-line>,<institution>Oulu University Hospital</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af83"><addr-line>Department of Children and Young People and Families</addr-line>,<institution>National Institute for Health and Welfare</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:aff id="af27"><addr-line>Population, Policy and Practice, UCL Institute of Child Health</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af84"><institution>School of Population Health and Sansom Institute</institution>,<institution>University of South Australia</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af85"><institution>South Australian Health and Medical Research Institute</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="af18"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af19"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af86"><institution>Oxford National Institute for Health Research (NIHR) Biomedical Research Centre, Churchill Hospital</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Lindi, Virpi" sort="Lindi, Virpi" uniqKey="Lindi V" first="Virpi" last="Lindi">Virpi Lindi</name><affiliation><nlm:aff id="af25"><addr-line>Institute of Biomedicine, Physiology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Harri, Niinikoski" sort="Harri, Niinikoski" uniqKey="Harri N" first="Niinikoski" last="Harri">Niinikoski Harri</name><affiliation><nlm:aff id="af23"><addr-line>Department of Pediatrics</addr-line>,<institution>Turku University Hospital, University of Turku</institution>,<addr-line>Turku</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Korner, Antje" sort="Korner, Antje" uniqKey="Korner A" first="Antje" last="Körner">Antje Körner</name><affiliation><nlm:aff id="af57"><addr-line>Center of Pediatric Research, Department of Women’s and Child Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="B Nnelykke, Klaus" sort="B Nnelykke, Klaus" uniqKey="B Nnelykke K" first="Klaus" last="B Nnelykke">Klaus B Nnelykke</name><affiliation><nlm:aff id="af44"><addr-line>COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation><nlm:aff id="af15"><institution>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name><affiliation><nlm:aff id="af14"><addr-line>Department of Epidemiology Research</addr-line>,<institution>Statens Serum Institut</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af87"><addr-line>Department of Medicine</addr-line>,<institution>Stanford University School of Medicine</institution>,<addr-line>Stanford, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Department of Internal Medicine</addr-line>,<institution>Erasmus MC, University Medical Center Rotterdam</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation><nlm:aff id="af5"><addr-line>Center for Applied Genomics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af6"><addr-line>Division of Human Genetics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af76"><addr-line>Department of Obstetrics and Gynecology, Sahlgrenska Academy</addr-line>,<institution>Sahlgrenska University Hosptial</institution>,<addr-line>Gothenburg</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name><affiliation><nlm:aff id="af12"><addr-line>MRC Integrative Epidemiology Unit at the University of Bristol</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af13"><addr-line>Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine</addr-line>,<institution>University of Bristol</institution>,<addr-line>Bristol</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="af12"><addr-line>MRC Integrative Epidemiology Unit at the University of Bristol</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="S Rensen, Thorkild I A" sort="S Rensen, Thorkild I A" uniqKey="S Rensen T" first="Thorkild I. A." last="S Rensen">Thorkild I. A. S Rensen</name><affiliation><nlm:aff id="af12"><addr-line>MRC Integrative Epidemiology Unit at the University of Bristol</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af45"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af88"><addr-line>Institute of Preventive Medicine</addr-line>,<institution>Bispebjerg and Frederiksberg Hospital, The Capital Region</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name><affiliation><nlm:aff id="af12"><addr-line>MRC Integrative Epidemiology Unit at the University of Bristol</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F. A." last="Grant">Struan F. A. Grant</name><affiliation><nlm:aff id="af5"><addr-line>Center for Applied Genomics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af6"><addr-line>Division of Human Genetics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af7"><addr-line>Division of Endocrinology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af75"><addr-line>Department of Pediatrics, Perelman School of Medicine</addr-line>,<institution>University of Pennsylvania</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W. V." last="Jaddoe">Vincent W. V. Jaddoe</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Pediatrics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26604143</idno><idno type="pmc">4854022</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854022</idno><idno type="RBID">PMC:4854022</idno><idno type="doi">10.1093/hmg/ddv472</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000442</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000442</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index</title><author><name sortKey="Felix, Janine F" sort="Felix, Janine F" uniqKey="Felix J" first="Janine F." last="Felix">Janine F. Felix</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Pediatrics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P." last="Bradfield">Jonathan P. Bradfield</name><affiliation><nlm:aff id="af5"><addr-line>Center for Applied Genomics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Monnereau, Claire" sort="Monnereau, Claire" uniqKey="Monnereau C" first="Claire" last="Monnereau">Claire Monnereau</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Pediatrics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Van Der Valk, Ralf J P" sort="Van Der Valk, Ralf J P" uniqKey="Van Der Valk R" first="Ralf J. P." last="Van Der Valk">Ralf J. P. Van Der Valk</name><affiliation><nlm:aff id="af9"><addr-line>Department of Pulmonology, GRIAC (Groningen Research Institute for Asthma and COPD)</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Stergiakouli, Evie" sort="Stergiakouli, Evie" uniqKey="Stergiakouli E" first="Evie" last="Stergiakouli">Evie Stergiakouli</name><affiliation><nlm:aff id="af12"><addr-line>MRC Integrative Epidemiology Unit at the University of Bristol</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chesi, Alessandra" sort="Chesi, Alessandra" uniqKey="Chesi A" first="Alessandra" last="Chesi">Alessandra Chesi</name><affiliation><nlm:aff id="af6"><addr-line>Division of Human Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Gaillard, Romy" sort="Gaillard, Romy" uniqKey="Gaillard R" first="Romy" last="Gaillard">Romy Gaillard</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Pediatrics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Feenstra, Bjarke" sort="Feenstra, Bjarke" uniqKey="Feenstra B" first="Bjarke" last="Feenstra">Bjarke Feenstra</name><affiliation><nlm:aff id="af14"><addr-line>Department of Epidemiology Research</addr-line>,<institution>Statens Serum Institut</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name><affiliation><nlm:aff id="af15"><institution>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af16"><addr-line>Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital</addr-line>,<institution>University of Munich Medical Center</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Kreiner M Ller, Eskil" sort="Kreiner M Ller, Eskil" uniqKey="Kreiner M Ller E" first="Eskil" last="Kreiner-M Ller">Eskil Kreiner-M Ller</name><affiliation><nlm:aff id="af44"><addr-line>COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mahajan, Anubha" sort="Mahajan, Anubha" uniqKey="Mahajan A" first="Anubha" last="Mahajan">Anubha Mahajan</name><affiliation><nlm:aff id="af18"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Pitk Nen, Niina" sort="Pitk Nen, Niina" uniqKey="Pitk Nen N" first="Niina" last="Pitk Nen">Niina Pitk Nen</name><affiliation><nlm:aff id="af20"><addr-line>Research Centre of Applied and Preventive Cardiovascular Medicine</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af24"><addr-line>Institute of Clinical Medicine, Neurology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Joro, Raimo" sort="Joro, Raimo" uniqKey="Joro R" first="Raimo" last="Joro">Raimo Joro</name><affiliation><nlm:aff id="af25"><addr-line>Institute of Biomedicine, Physiology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Cavadino, Alana" sort="Cavadino, Alana" uniqKey="Cavadino A" first="Alana" last="Cavadino">Alana Cavadino</name><affiliation><nlm:aff id="af26"><addr-line>Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry</addr-line>,<institution>Queen Mary University of London</institution>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af27"><addr-line>Population, Policy and Practice, UCL Institute of Child Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Huikari, Ville" sort="Huikari, Ville" uniqKey="Huikari V" first="Ville" last="Huikari">Ville Huikari</name><affiliation><nlm:aff id="af29"><addr-line>Centre for Life Course Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Franks, Steve" sort="Franks, Steve" uniqKey="Franks S" first="Steve" last="Franks">Steve Franks</name><affiliation><nlm:aff id="af32"><addr-line>Institute of Reproductive and Developmental Biology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Groen Blokhuis, Maria M" sort="Groen Blokhuis, Maria M" uniqKey="Groen Blokhuis M" first="Maria M." last="Groen-Blokhuis">Maria M. Groen-Blokhuis</name><affiliation><nlm:aff id="af34"><addr-line>Department of Biological Psychology</addr-line>,<institution>VU University Amsterdam</institution>,<institution>NCA Neuroscience Campus Amsterdam</institution>,<institution>EMGO+ Institute for Health and Care Research</institution>,<addr-line>Amsterdam</addr-line>,<country>the Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L." last="Cousminer">Diana L. Cousminer</name><affiliation><nlm:aff id="af35"><addr-line>Institute for Molecular Medicine, Finland (FIMM)</addr-line>,<institution>University of Helsinki</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Marsh, Julie A" sort="Marsh, Julie A" uniqKey="Marsh J" first="Julie A." last="Marsh">Julie A. Marsh</name><affiliation><nlm:aff id="af36"><addr-line>School of Women's and Infants’ Health</addr-line>,<institution>The University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="af37"><addr-line>Department of Clinical Chemistry</addr-line>,<institution>Fimlab Laboratories</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af38"><addr-line>Department of Clinical Chemistry</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Curtin, John A" sort="Curtin, John A" uniqKey="Curtin J" first="John A." last="Curtin">John A. Curtin</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair</addr-line>,<institution>University of Manchester</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af41"><institution>University Hospital of South Manchester, Manchester Academic Health Sciences Centre</institution>,<addr-line>Manchester</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Vioque, Jesus" sort="Vioque, Jesus" uniqKey="Vioque J" first="Jesus" last="Vioque">Jesus Vioque</name><affiliation><nlm:aff id="af42"><institution>Universidad Miguel Hernandez</institution>,<addr-line>Elche-Alicante</addr-line>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af43"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Ahluwalia, Tarunveer S" sort="Ahluwalia, Tarunveer S" uniqKey="Ahluwalia T" first="Tarunveer S." last="Ahluwalia">Tarunveer S. Ahluwalia</name><affiliation><nlm:aff id="af44"><addr-line>COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af45"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af46"><institution>Steno Diabetes Center</institution>,<addr-line>Gentofte</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Myhre, Ronny" sort="Myhre, Ronny" uniqKey="Myhre R" first="Ronny" last="Myhre">Ronny Myhre</name><affiliation><nlm:aff id="af47"><addr-line>Department of Genes and Envrionment, Division of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Price, Thomas S" sort="Price, Thomas S" uniqKey="Price T" first="Thomas S." last="Price">Thomas S. Price</name><affiliation><nlm:aff id="af49"><addr-line>Department of Systems Pharmacology and Translational Therapeutics</addr-line>,<institution>University of Pennsylvania Perelman School of Medicine</institution>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Vilor Tejedor, Natalia" sort="Vilor Tejedor, Natalia" uniqKey="Vilor Tejedor N" first="Natalia" last="Vilor-Tejedor">Natalia Vilor-Tejedor</name><affiliation><nlm:aff id="af43"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>Centre for Research in Environmental Epidemiology (CREAL)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af51"><institution>Pompeu Fabra University (UPF)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loïc" last="Yengo">Loïc Yengo</name><affiliation><nlm:aff id="af52"><institution>CNRS UMR8199, Pasteur Institute Lille</institution>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af53"><institution>European Genomic Institute for Diabetes (EGID)</institution>,<addr-line>Lille</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Grarup, Niels" sort="Grarup, Niels" uniqKey="Grarup N" first="Niels" last="Grarup">Niels Grarup</name><affiliation><nlm:aff id="af45"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Ntalla, Ioanna" sort="Ntalla, Ioanna" uniqKey="Ntalla I" first="Ioanna" last="Ntalla">Ioanna Ntalla</name><affiliation><nlm:aff id="af54"><addr-line>Department of Health Sciences</addr-line>,<institution>University of Leicester</institution>,<addr-line>Leicester</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af55"><addr-line>Department of Nutrition and Dietetics, School of Health Science and Education</addr-line>,<institution>Harokopio University</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Ang, Wei" sort="Ang, Wei" uniqKey="Ang W" first="Wei" last="Ang">Wei Ang</name><affiliation><nlm:aff id="af36"><addr-line>School of Women's and Infants’ Health</addr-line>,<institution>The University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Atalay, Mustafa" sort="Atalay, Mustafa" uniqKey="Atalay M" first="Mustafa" last="Atalay">Mustafa Atalay</name><affiliation><nlm:aff id="af25"><addr-line>Institute of Biomedicine, Physiology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name><affiliation><nlm:aff id="af44"><addr-line>COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Blakemore, Alexandra I" sort="Blakemore, Alexandra I" uniqKey="Blakemore A" first="Alexandra I." last="Blakemore">Alexandra I. Blakemore</name><affiliation><nlm:aff id="af33"><addr-line>Section of Investigative Medicine, Division of Diabetes, Endocrinology, and Metabolism, Faculty of Medicine</addr-line>,<institution>Imperial College</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Bonnefond, Amelie" sort="Bonnefond, Amelie" uniqKey="Bonnefond A" first="Amelie" last="Bonnefond">Amelie Bonnefond</name><affiliation><nlm:aff id="af52"><institution>CNRS UMR8199, Pasteur Institute Lille</institution>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af53"><institution>European Genomic Institute for Diabetes (EGID)</institution>,<addr-line>Lille</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Carstensen, Lisbeth" sort="Carstensen, Lisbeth" uniqKey="Carstensen L" first="Lisbeth" last="Carstensen">Lisbeth Carstensen</name><affiliation><nlm:aff id="af14"><addr-line>Department of Epidemiology Research</addr-line>,<institution>Statens Serum Institut</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name><affiliation><nlm:aff id="af56"><institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Flexeder, Claudia" sort="Flexeder, Claudia" uniqKey="Flexeder C" first="Claudia" last="Flexeder">Claudia Flexeder</name><affiliation><nlm:aff id="af15"><institution>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation><nlm:aff id="af10"><addr-line>Department of Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name><affiliation><nlm:aff id="af14"><addr-line>Department of Epidemiology Research</addr-line>,<institution>Statens Serum Institut</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Geserick, Mandy" sort="Geserick, Mandy" uniqKey="Geserick M" first="Mandy" last="Geserick">Mandy Geserick</name><affiliation><nlm:aff id="af57"><addr-line>Center of Pediatric Research, Department of Women’s and Child Health</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af58"><addr-line>LIFE Child (Leipzig Research Center for Civilization Diseases)</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="af30"><addr-line>Institute of Clinical Medicine/Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Haworth, Claire M A" sort="Haworth, Claire M A" uniqKey="Haworth C" first="Claire M. A." last="Haworth">Claire M. A. Haworth</name><affiliation><nlm:aff id="af60"><addr-line>Department of Psychology</addr-line>,<institution>University of Warwick</institution>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><nlm:aff id="af61"><addr-line>Division of Endocrinology and Center for Basic and Translational Obesity Research</addr-line>,<institution>Boston Children's Hospital</institution>,<addr-line>Boston</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af62"><addr-line>Medical and Population Genetics Program</addr-line>,<institution>Broad Institute of MIT and Harvard</institution>,<addr-line>Cambridge</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Department of Genetics</addr-line>,<institution>Harvard Medical School</institution>,<addr-line>Boston</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Holm, Jens Christian" sort="Holm, Jens Christian" uniqKey="Holm J" first="Jens-Christian" last="Holm">Jens-Christian Holm</name><affiliation><nlm:aff id="af64"><addr-line>The Children's Obesity Clinic, Department of Pediatrics</addr-line>,<institution>Copenhagen University Hospital Holbæk, The Danish Childhood Obesity Biobank</institution>,<country>Denmark</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Institute of Medicine, Copenhagen University,</institution><addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Horikoshi, Momoko" sort="Horikoshi, Momoko" uniqKey="Horikoshi M" first="Momoko" last="Horikoshi">Momoko Horikoshi</name><affiliation><nlm:aff id="af18"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af19"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke Jan" last="Hottenga">Jouke Jan Hottenga</name><affiliation><nlm:aff id="af34"><addr-line>Department of Biological Psychology</addr-line>,<institution>VU University Amsterdam</institution>,<institution>NCA Neuroscience Campus Amsterdam</institution>,<institution>EMGO+ Institute for Health and Care Research</institution>,<addr-line>Amsterdam</addr-line>,<country>the Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Huang, Jinyan" sort="Huang, Jinyan" uniqKey="Huang J" first="Jinyan" last="Huang">Jinyan Huang</name><affiliation><nlm:aff id="af66"><addr-line>State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology</addr-line>,<institution>Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</nlm:aff></affiliation></author><author><name sortKey="Kadarmideen, Haja N" sort="Kadarmideen, Haja N" uniqKey="Kadarmideen H" first="Haja N." last="Kadarmideen">Haja N. Kadarmideen</name><affiliation><nlm:aff id="af67"><addr-line>Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Frederiksberg C</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="af39"><addr-line>Department of Clinical Physiology</addr-line>,<institution>University of Tampere School of Medicine</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af68"><addr-line>Department of Clinical Physiology</addr-line>,<institution>Tampere University Hospital</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Kiess, Wieland" sort="Kiess, Wieland" uniqKey="Kiess W" first="Wieland" last="Kiess">Wieland Kiess</name><affiliation><nlm:aff id="af57"><addr-line>Center of Pediatric Research, Department of Women’s and Child Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lakka, Hanna Maaria" sort="Lakka, Hanna Maaria" uniqKey="Lakka H" first="Hanna-Maaria" last="Lakka">Hanna-Maaria Lakka</name><affiliation><nlm:aff id="af25"><addr-line>Institute of Biomedicine, Physiology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Lakka, Timo A" sort="Lakka, Timo A" uniqKey="Lakka T" first="Timo A." last="Lakka">Timo A. Lakka</name><affiliation><nlm:aff id="af25"><addr-line>Institute of Biomedicine, Physiology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af69"><institution>Kuopio Research Institute of Exercise Medicine</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af70"><addr-line>Department of Clinical Physiology and Nuclear Medicine</addr-line>,<institution>Kuopio University Hospital</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Lewin, Alexandra M" sort="Lewin, Alexandra M" uniqKey="Lewin A" first="Alexandra M." last="Lewin">Alexandra M. Lewin</name><affiliation><nlm:aff id="af71"><addr-line>Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="af72"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af73"><addr-line>Department of Biostatistics</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation><nlm:aff id="af37"><addr-line>Department of Clinical Chemistry</addr-line>,<institution>Fimlab Laboratories</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af38"><addr-line>Department of Clinical Chemistry</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ma, Baoshan" sort="Ma, Baoshan" uniqKey="Ma B" first="Baoshan" last="Ma">Baoshan Ma</name><affiliation><nlm:aff id="af74"><addr-line>College of Information Science and Technology</addr-line>,<institution>Dalian Maritime University</institution>,<addr-line>Dalian, Liaoning Province</addr-line>,<country>China</country>,</nlm:aff></affiliation></author><author><name sortKey="Magnus, Per" sort="Magnus, Per" uniqKey="Magnus P" first="Per" last="Magnus">Per Magnus</name><affiliation><nlm:aff id="af48"><addr-line>Division of Epidemiology</addr-line>,<institution>Norwegian Institute of Public Health</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</nlm:aff></affiliation></author><author><name sortKey="Mccormack, Shana E" sort="Mccormack, Shana E" uniqKey="Mccormack S" first="Shana E." last="Mccormack">Shana E. Mccormack</name><affiliation><nlm:aff id="af6"><addr-line>Division of Human Genetics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af7"><addr-line>Division of Endocrinology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af75"><addr-line>Department of Pediatrics, Perelman School of Medicine</addr-line>,<institution>University of Pennsylvania</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name><affiliation><nlm:aff id="af12"><addr-line>MRC Integrative Epidemiology Unit at the University of Bristol</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mentch, Frank D" sort="Mentch, Frank D" uniqKey="Mentch F" first="Frank D." last="Mentch">Frank D. Mentch</name><affiliation><nlm:aff id="af5"><addr-line>Center for Applied Genomics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Middeldorp, Christel M" sort="Middeldorp, Christel M" uniqKey="Middeldorp C" first="Christel M." last="Middeldorp">Christel M. Middeldorp</name><affiliation><nlm:aff id="af34"><addr-line>Department of Biological Psychology</addr-line>,<institution>VU University Amsterdam</institution>,<institution>NCA Neuroscience Campus Amsterdam</institution>,<institution>EMGO+ Institute for Health and Care Research</institution>,<addr-line>Amsterdam</addr-line>,<country>the Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Murray, Clare S" sort="Murray, Clare S" uniqKey="Murray C" first="Clare S." last="Murray">Clare S. Murray</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair</addr-line>,<institution>University of Manchester</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af41"><institution>University Hospital of South Manchester, Manchester Academic Health Sciences Centre</institution>,<addr-line>Manchester</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Pahkala, Katja" sort="Pahkala, Katja" uniqKey="Pahkala K" first="Katja" last="Pahkala">Katja Pahkala</name><affiliation><nlm:aff id="af20"><addr-line>Research Centre of Applied and Preventive Cardiovascular Medicine</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af21"><addr-line>Department of Health and Physical Activity, Paavo Nurmi Centre, Sports and Exercise Medicine Unit</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Pers, Tune H" sort="Pers, Tune H" uniqKey="Pers T" first="Tune H." last="Pers">Tune H. Pers</name><affiliation><nlm:aff id="af61"><addr-line>Division of Endocrinology and Center for Basic and Translational Obesity Research</addr-line>,<institution>Boston Children's Hospital</institution>,<addr-line>Boston</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af62"><addr-line>Medical and Population Genetics Program</addr-line>,<institution>Broad Institute of MIT and Harvard</institution>,<addr-line>Cambridge</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Pf Ffle, Roland" sort="Pf Ffle, Roland" uniqKey="Pf Ffle R" first="Roland" last="Pf Ffle">Roland Pf Ffle</name><affiliation><nlm:aff id="af57"><addr-line>Center of Pediatric Research, Department of Women’s and Child Health</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af59"><addr-line>CrescNet, Medical Faculty</addr-line>,<institution>University of Leipzig</institution>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name><affiliation><nlm:aff id="af9"><addr-line>Department of Pulmonology, GRIAC (Groningen Research Institute for Asthma and COPD)</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Power, Christine" sort="Power, Christine" uniqKey="Power C" first="Christine" last="Power">Christine Power</name><affiliation><nlm:aff id="af27"><addr-line>Population, Policy and Practice, UCL Institute of Child Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Simpson, Angela" sort="Simpson, Angela" uniqKey="Simpson A" first="Angela" last="Simpson">Angela Simpson</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair</addr-line>,<institution>University of Manchester</institution></nlm:aff></affiliation></author><author><name sortKey="Sengpiel, Verena" sort="Sengpiel, Verena" uniqKey="Sengpiel V" first="Verena" last="Sengpiel">Verena Sengpiel</name><affiliation><nlm:aff id="af76"><addr-line>Department of Obstetrics and Gynecology, Sahlgrenska Academy</addr-line>,<institution>Sahlgrenska University Hosptial</institution>,<addr-line>Gothenburg</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Tiesler, Carla M T" sort="Tiesler, Carla M T" uniqKey="Tiesler C" first="Carla M. T." last="Tiesler">Carla M. T. Tiesler</name><affiliation><nlm:aff id="af15"><institution>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af16"><addr-line>Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital</addr-line>,<institution>University of Munich Medical Center</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Torrent, Maties" sort="Torrent, Maties" uniqKey="Torrent M" first="Maties" last="Torrent">Maties Torrent</name><affiliation><nlm:aff id="af43"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af77"><institution>Area de Salut de Menorca, ib-salut</institution>,<addr-line>Menorca</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Department of Internal Medicine</addr-line>,<institution>Erasmus MC, University Medical Center Rotterdam</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Van Meurs, Joyce B" sort="Van Meurs, Joyce B" uniqKey="Van Meurs J" first="Joyce B." last="Van Meurs">Joyce B. Van Meurs</name><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Department of Internal Medicine</addr-line>,<institution>Erasmus MC, University Medical Center Rotterdam</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Vinding, Rebecca" sort="Vinding, Rebecca" uniqKey="Vinding R" first="Rebecca" last="Vinding">Rebecca Vinding</name><affiliation><nlm:aff id="af17"><addr-line>Department of Pediatrics, Naestved Hospital, Naestved, Denmark</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af44"><addr-line>COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Waage, Johannes" sort="Waage, Johannes" uniqKey="Waage J" first="Johannes" last="Waage">Johannes Waage</name><affiliation><nlm:aff id="af44"><addr-line>COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Wardle, Jane" sort="Wardle, Jane" uniqKey="Wardle J" first="Jane" last="Wardle">Jane Wardle</name><affiliation><nlm:aff id="af28"><addr-line>Department of Epidemiology and Public Health</addr-line>,<institution>University College London</institution>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Zeggini, Eleftheria" sort="Zeggini, Eleftheria" uniqKey="Zeggini E" first="Eleftheria" last="Zeggini">Eleftheria Zeggini</name><affiliation><nlm:aff id="af78"><institution>Wellcome Trust Sanger Institute, The Morgan Building, Wellcome Trust Genome Campus</institution>,<addr-line>Hinxton, Cambridgeshire</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Zemel, Babette S" sort="Zemel, Babette S" uniqKey="Zemel B" first="Babette S." last="Zemel">Babette S. Zemel</name><affiliation><nlm:aff id="af8"><addr-line>Division of Gastroenterology, Hepatology and Nutrition</addr-line>,<institution>The Children's Hospital of Philadelphia</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af75"><addr-line>Department of Pediatrics, Perelman School of Medicine</addr-line>,<institution>University of Pennsylvania</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V." last="Dedoussis">George V. Dedoussis</name><affiliation><nlm:aff id="af55"><addr-line>Department of Nutrition and Dietetics, School of Health Science and Education</addr-line>,<institution>Harokopio University</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Oluf" sort="Pedersen, Oluf" uniqKey="Pedersen O" first="Oluf" last="Pedersen">Oluf Pedersen</name><affiliation><nlm:aff id="af45"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="af52"><institution>CNRS UMR8199, Pasteur Institute Lille</institution>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af79"><addr-line>Department of Genomics of Common Disease</addr-line>,<institution>School of Public Health, Imperial College London, Hammersmith Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name><affiliation><nlm:aff id="af43"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>Centre for Research in Environmental Epidemiology (CREAL)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af51"><institution>Pompeu Fabra University (UPF)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af80"><institution>IMIM (Hospital del Mar Medical Research Institute)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Plomin, Robert" sort="Plomin, Robert" uniqKey="Plomin R" first="Robert" last="Plomin">Robert Plomin</name><affiliation><nlm:aff id="af81"><addr-line>King's College London, MRC Social, Genetic and Developmental Psychiatry Centre</addr-line>,<institution>Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Jacobsson, Bo" sort="Jacobsson, Bo" uniqKey="Jacobsson B" first="Bo" last="Jacobsson">Bo Jacobsson</name><affiliation><nlm:aff id="af47"><addr-line>Department of Genes and Envrionment, Division of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af76"><addr-line>Department of Obstetrics and Gynecology, Sahlgrenska Academy</addr-line>,<institution>Sahlgrenska University Hosptial</institution>,<addr-line>Gothenburg</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation><nlm:aff id="af45"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Gonzalez, Juan R" sort="Gonzalez, Juan R" uniqKey="Gonzalez J" first="Juan R." last="Gonzalez">Juan R. Gonzalez</name><affiliation><nlm:aff id="af43"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>Centre for Research in Environmental Epidemiology (CREAL)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af51"><institution>Pompeu Fabra University (UPF)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Custovic, Adnan" sort="Custovic, Adnan" uniqKey="Custovic A" first="Adnan" last="Custovic">Adnan Custovic</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair</addr-line>,<institution>University of Manchester</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af41"><institution>University Hospital of South Manchester, Manchester Academic Health Sciences Centre</institution>,<addr-line>Manchester</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><affiliation><nlm:aff id="af20"><addr-line>Research Centre of Applied and Preventive Cardiovascular Medicine</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af22"><addr-line>Department of Clinical Physiology and Nuclear Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name><affiliation><nlm:aff id="af36"><addr-line>School of Women's and Infants’ Health</addr-line>,<institution>The University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widén">Elisabeth Widén</name><affiliation><nlm:aff id="af35"><addr-line>Institute for Molecular Medicine, Finland (FIMM)</addr-line>,<institution>University of Helsinki</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="af34"><addr-line>Department of Biological Psychology</addr-line>,<institution>VU University Amsterdam</institution>,<institution>NCA Neuroscience Campus Amsterdam</institution>,<institution>EMGO+ Institute for Health and Care Research</institution>,<addr-line>Amsterdam</addr-line>,<country>the Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name><affiliation><nlm:aff id="af11"><addr-line>Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC (Groningen Research Institute for Asthma and COPD)</addr-line>,<institution>University of Groningen, University Medical Center Groningen</institution>,<addr-line>Groningen</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Sebert, Sylvain" sort="Sebert, Sylvain" uniqKey="Sebert S" first="Sylvain" last="Sebert">Sylvain Sebert</name><affiliation><nlm:aff id="af29"><addr-line>Centre for Life Course Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af31"><addr-line>Biocenter Oulu</addr-line>,<institution>University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation><nlm:aff id="af29"><addr-line>Centre for Life Course Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af31"><addr-line>Biocenter Oulu</addr-line>,<institution>University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af71"><addr-line>Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af82"><addr-line>Unit of Primary Care</addr-line>,<institution>Oulu University Hospital</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af83"><addr-line>Department of Children and Young People and Families</addr-line>,<institution>National Institute for Health and Welfare</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:aff id="af27"><addr-line>Population, Policy and Practice, UCL Institute of Child Health</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af84"><institution>School of Population Health and Sansom Institute</institution>,<institution>University of South Australia</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af85"><institution>South Australian Health and Medical Research Institute</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="af18"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af19"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af86"><institution>Oxford National Institute for Health Research (NIHR) Biomedical Research Centre, Churchill Hospital</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Lindi, Virpi" sort="Lindi, Virpi" uniqKey="Lindi V" first="Virpi" last="Lindi">Virpi Lindi</name><affiliation><nlm:aff id="af25"><addr-line>Institute of Biomedicine, Physiology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Harri, Niinikoski" sort="Harri, Niinikoski" uniqKey="Harri N" first="Niinikoski" last="Harri">Niinikoski Harri</name><affiliation><nlm:aff id="af23"><addr-line>Department of Pediatrics</addr-line>,<institution>Turku University Hospital, University of Turku</institution>,<addr-line>Turku</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Korner, Antje" sort="Korner, Antje" uniqKey="Korner A" first="Antje" last="Körner">Antje Körner</name><affiliation><nlm:aff id="af57"><addr-line>Center of Pediatric Research, Department of Women’s and Child Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="B Nnelykke, Klaus" sort="B Nnelykke, Klaus" uniqKey="B Nnelykke K" first="Klaus" last="B Nnelykke">Klaus B Nnelykke</name><affiliation><nlm:aff id="af44"><addr-line>COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation><nlm:aff id="af15"><institution>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name><affiliation><nlm:aff id="af14"><addr-line>Department of Epidemiology Research</addr-line>,<institution>Statens Serum Institut</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af87"><addr-line>Department of Medicine</addr-line>,<institution>Stanford University School of Medicine</institution>,<addr-line>Stanford, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Department of Internal Medicine</addr-line>,<institution>Erasmus MC, University Medical Center Rotterdam</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation><nlm:aff id="af5"><addr-line>Center for Applied Genomics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af6"><addr-line>Division of Human Genetics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af76"><addr-line>Department of Obstetrics and Gynecology, Sahlgrenska Academy</addr-line>,<institution>Sahlgrenska University Hosptial</institution>,<addr-line>Gothenburg</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name><affiliation><nlm:aff id="af12"><addr-line>MRC Integrative Epidemiology Unit at the University of Bristol</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af13"><addr-line>Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine</addr-line>,<institution>University of Bristol</institution>,<addr-line>Bristol</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="af12"><addr-line>MRC Integrative Epidemiology Unit at the University of Bristol</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="S Rensen, Thorkild I A" sort="S Rensen, Thorkild I A" uniqKey="S Rensen T" first="Thorkild I. A." last="S Rensen">Thorkild I. A. S Rensen</name><affiliation><nlm:aff id="af12"><addr-line>MRC Integrative Epidemiology Unit at the University of Bristol</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af45"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af88"><addr-line>Institute of Preventive Medicine</addr-line>,<institution>Bispebjerg and Frederiksberg Hospital, The Capital Region</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name><affiliation><nlm:aff id="af12"><addr-line>MRC Integrative Epidemiology Unit at the University of Bristol</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F. A." last="Grant">Struan F. A. Grant</name><affiliation><nlm:aff id="af5"><addr-line>Center for Applied Genomics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af6"><addr-line>Division of Human Genetics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af7"><addr-line>Division of Endocrinology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af75"><addr-line>Department of Pediatrics, Perelman School of Medicine</addr-line>,<institution>University of Pennsylvania</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W. V." last="Jaddoe">Vincent W. V. Jaddoe</name><affiliation><nlm:aff id="af1"><addr-line>The Generation R Study Group</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Pediatrics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (<italic>P</italic>-value < 5 × 10<sup>−8</sup>) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to <italic>ADCY3</italic>, <italic>GNPDA2</italic>, <italic>TMEM18</italic>, <italic>SEC16B</italic>, <italic>FAIM2</italic>, <italic>FTO</italic>, <italic>TFAP2B</italic>, <italic>TNNI3K</italic>, <italic>MC4R</italic>, <italic>GPR61, LMX1B</italic> and <italic>OLFM4</italic> associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near <italic>ELP3</italic>, rs8092503 near <italic>RAB27B</italic> and rs13387838 near <italic>ADAM23</italic>. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, <italic>P</italic>-value = 3.12 × 10<sup>−10</sup>) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in strength of the associations with body mass index.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id><journal-id journal-id-type="iso-abbrev">Hum. Mol. Genet</journal-id><journal-id journal-id-type="publisher-id">hmg</journal-id><journal-id journal-id-type="hwp">hmg</journal-id><journal-title-group><journal-title>Human Molecular Genetics</journal-title></journal-title-group><issn pub-type="ppub">0964-6906</issn><issn pub-type="epub">1460-2083</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26604143</article-id><article-id pub-id-type="pmc">4854022</article-id><article-id pub-id-type="doi">10.1093/hmg/ddv472</article-id><article-id pub-id-type="publisher-id">ddv472</article-id><article-categories><subj-group subj-group-type="heading"><subject>Association Studies Articles</subject></subj-group></article-categories><title-group><article-title>Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Felix</surname><given-names>Janine F.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref><xref ref-type="author-notes" rid="AN1">†</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Bradfield</surname><given-names>Jonathan P.</given-names></name><xref ref-type="aff" rid="af5">5</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Monnereau</surname><given-names>Claire</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>van der Valk</surname><given-names>Ralf J.P.</given-names></name><xref ref-type="aff" rid="af9">9</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Stergiakouli</surname><given-names>Evie</given-names></name><xref ref-type="aff" rid="af12">12</xref></contrib><contrib contrib-type="author"><name><surname>Chesi</surname><given-names>Alessandra</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Gaillard</surname><given-names>Romy</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Feenstra</surname><given-names>Bjarke</given-names></name><xref ref-type="aff" rid="af14">14</xref></contrib><contrib contrib-type="author"><name><surname>Thiering</surname><given-names>Elisabeth</given-names></name><xref ref-type="aff" rid="af15">15</xref><xref ref-type="aff" rid="af16">16</xref></contrib><contrib 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rid="af29">29</xref></contrib><contrib contrib-type="author"><name><surname>Franks</surname><given-names>Steve</given-names></name><xref ref-type="aff" rid="af32">32</xref></contrib><contrib contrib-type="author"><name><surname>Groen-Blokhuis</surname><given-names>Maria M.</given-names></name><xref ref-type="aff" rid="af34">34</xref></contrib><contrib contrib-type="author"><name><surname>Cousminer</surname><given-names>Diana L.</given-names></name><xref ref-type="aff" rid="af35">35</xref></contrib><contrib contrib-type="author"><name><surname>Marsh</surname><given-names>Julie A.</given-names></name><xref ref-type="aff" rid="af36">36</xref></contrib><contrib contrib-type="author"><name><surname>Lehtimäki</surname><given-names>Terho</given-names></name><xref ref-type="aff" rid="af37">37</xref><xref ref-type="aff" rid="af38">38</xref></contrib><contrib contrib-type="author"><name><surname>Curtin</surname><given-names>John A.</given-names></name><xref ref-type="aff" rid="af40">40</xref><xref ref-type="aff" rid="af41">41</xref></contrib><contrib contrib-type="author"><name><surname>Vioque</surname><given-names>Jesus</given-names></name><xref ref-type="aff" rid="af42">42</xref><xref ref-type="aff" rid="af43">43</xref></contrib><contrib contrib-type="author"><name><surname>Ahluwalia</surname><given-names>Tarunveer S.</given-names></name><xref ref-type="aff" rid="af44">44</xref><xref ref-type="aff" rid="af45">45</xref><xref ref-type="aff" rid="af46">46</xref></contrib><contrib contrib-type="author"><name><surname>Myhre</surname><given-names>Ronny</given-names></name><xref ref-type="aff" rid="af47">47</xref></contrib><contrib contrib-type="author"><name><surname>Price</surname><given-names>Thomas S.</given-names></name><xref ref-type="aff" rid="af49">49</xref></contrib><contrib contrib-type="author"><name><surname>Vilor-Tejedor</surname><given-names>Natalia</given-names></name><xref ref-type="aff" rid="af43">43</xref><xref ref-type="aff" 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contrib-type="author"><name><surname>Magnus</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="af48">48</xref></contrib><contrib contrib-type="author"><name><surname>McCormack</surname><given-names>Shana E.</given-names></name><xref ref-type="aff" rid="af6">6</xref><xref ref-type="aff" rid="af7">7</xref><xref ref-type="aff" rid="af75">75</xref></contrib><contrib contrib-type="author"><name><surname>McMahon</surname><given-names>George</given-names></name><xref ref-type="aff" rid="af12">12</xref></contrib><contrib contrib-type="author"><name><surname>Mentch</surname><given-names>Frank D.</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Middeldorp</surname><given-names>Christel M.</given-names></name><xref ref-type="aff" rid="af34">34</xref></contrib><contrib contrib-type="author"><name><surname>Murray</surname><given-names>Clare S.</given-names></name><xref ref-type="aff" rid="af40">40</xref><xref 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contrib-type="author"><name><surname>Waage</surname><given-names>Johannes</given-names></name><xref ref-type="aff" rid="af44">44</xref></contrib><contrib contrib-type="author"><name><surname>Wardle</surname><given-names>Jane</given-names></name><xref ref-type="aff" rid="af28">28</xref></contrib><contrib contrib-type="author"><name><surname>Zeggini</surname><given-names>Eleftheria</given-names></name><xref ref-type="aff" rid="af78">78</xref></contrib><contrib contrib-type="author"><name><surname>Zemel</surname><given-names>Babette S.</given-names></name><xref ref-type="aff" rid="af8">8</xref><xref ref-type="aff" rid="af75">75</xref></contrib><contrib contrib-type="author"><name><surname>Dedoussis</surname><given-names>George V.</given-names></name><xref ref-type="aff" rid="af55">55</xref></contrib><contrib contrib-type="author"><name><surname>Pedersen</surname><given-names>Oluf</given-names></name><xref ref-type="aff" rid="af45">45</xref></contrib><contrib contrib-type="author"><name><surname>Froguel</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="af52">52</xref><xref ref-type="aff" rid="af79">79</xref></contrib><contrib contrib-type="author"><name><surname>Sunyer</surname><given-names>Jordi</given-names></name><xref ref-type="aff" rid="af43">43</xref><xref ref-type="aff" rid="af50">50</xref><xref ref-type="aff" rid="af51">51</xref><xref ref-type="aff" rid="af80">80</xref></contrib><contrib contrib-type="author"><name><surname>Plomin</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="af81">81</xref></contrib><contrib contrib-type="author"><name><surname>Jacobsson</surname><given-names>Bo</given-names></name><xref ref-type="aff" rid="af47">47</xref><xref ref-type="aff" rid="af76">76</xref></contrib><contrib contrib-type="author"><name><surname>Hansen</surname><given-names>Torben</given-names></name><xref ref-type="aff" rid="af45">45</xref></contrib><contrib contrib-type="author"><name><surname>Gonzalez</surname><given-names>Juan R.</given-names></name><xref ref-type="aff" rid="af43">43</xref><xref ref-type="aff" rid="af50">50</xref><xref ref-type="aff" rid="af51">51</xref></contrib><contrib contrib-type="author"><name><surname>Custovic</surname><given-names>Adnan</given-names></name><xref ref-type="aff" rid="af40">40</xref><xref ref-type="aff" rid="af41">41</xref></contrib><contrib contrib-type="author"><name><surname>Raitakari</surname><given-names>Olli T.</given-names></name><xref ref-type="aff" rid="af20">20</xref><xref ref-type="aff" rid="af22">22</xref></contrib><contrib contrib-type="author"><name><surname>Pennell</surname><given-names>Craig E.</given-names></name><xref ref-type="aff" rid="af36">36</xref></contrib><contrib contrib-type="author"><name><surname>Widén</surname><given-names>Elisabeth</given-names></name><xref ref-type="aff" rid="af35">35</xref></contrib><contrib contrib-type="author"><name><surname>Boomsma</surname><given-names>Dorret I.</given-names></name><xref ref-type="aff" rid="af34">34</xref></contrib><contrib contrib-type="author"><name><surname>Koppelman</surname><given-names>Gerard H.</given-names></name><xref ref-type="aff" rid="af11">11</xref></contrib><contrib contrib-type="author"><name><surname>Sebert</surname><given-names>Sylvain</given-names></name><xref ref-type="aff" rid="af29">29</xref><xref ref-type="aff" rid="af31">31</xref></contrib><contrib contrib-type="author"><name><surname>Järvelin</surname><given-names>Marjo-Riitta</given-names></name><xref ref-type="aff" rid="af29">29</xref><xref ref-type="aff" rid="af31">31</xref><xref ref-type="aff" rid="af71">71</xref><xref ref-type="aff" rid="af82">82</xref><xref ref-type="aff" rid="af83">83</xref></contrib><contrib contrib-type="author"><name><surname>Hyppönen</surname><given-names>Elina</given-names></name><xref ref-type="aff" rid="af27">27</xref><xref ref-type="aff" rid="af84">84</xref><xref ref-type="aff" rid="af85">85</xref></contrib><contrib contrib-type="author"><name><surname>McCarthy</surname><given-names>Mark I.</given-names></name><xref ref-type="aff" rid="af18">18</xref><xref ref-type="aff" rid="af19">19</xref><xref ref-type="aff" rid="af86">86</xref></contrib><contrib contrib-type="author"><name><surname>Lindi</surname><given-names>Virpi</given-names></name><xref ref-type="aff" rid="af25">25</xref></contrib><contrib contrib-type="author"><name><surname>Harri</surname><given-names>Niinikoski</given-names></name><xref ref-type="aff" rid="af23">23</xref></contrib><contrib contrib-type="author"><name><surname>Körner</surname><given-names>Antje</given-names></name><xref ref-type="aff" rid="af57">57</xref></contrib><contrib contrib-type="author"><name><surname>Bønnelykke</surname><given-names>Klaus</given-names></name><xref ref-type="aff" rid="af44">44</xref></contrib><contrib contrib-type="author"><name><surname>Heinrich</surname><given-names>Joachim</given-names></name><xref ref-type="aff" rid="af15">15</xref></contrib><contrib contrib-type="author"><name><surname>Melbye</surname><given-names>Mads</given-names></name><xref ref-type="aff" rid="af14">14</xref><xref ref-type="aff" rid="af87">87</xref></contrib><contrib contrib-type="author"><name><surname>Rivadeneira</surname><given-names>Fernando</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Hakonarson</surname><given-names>Hakon</given-names></name><xref ref-type="aff" rid="af5">5</xref><xref ref-type="aff" rid="af6">6</xref><xref ref-type="aff" rid="af76">76</xref></contrib><contrib contrib-type="author"><name><surname>Ring</surname><given-names>Susan M.</given-names></name><xref ref-type="aff" rid="af12">12</xref><xref ref-type="aff" rid="af13">13</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>George Davey</given-names></name><xref ref-type="aff" rid="af12">12</xref></contrib><contrib contrib-type="author"><name><surname>Sørensen</surname><given-names>Thorkild I.A.</given-names></name><xref ref-type="aff" rid="af12">12</xref><xref ref-type="aff" rid="af45">45</xref><xref ref-type="aff" rid="af88">88</xref></contrib><contrib contrib-type="author"><name><surname>Timpson</surname><given-names>Nicholas J.</given-names></name><xref ref-type="aff" rid="af12">12</xref><xref ref-type="author-notes" rid="AN3">#</xref></contrib><contrib contrib-type="author"><name><surname>Grant</surname><given-names>Struan F.A.</given-names></name><xref ref-type="aff" rid="af5">5</xref><xref ref-type="aff" rid="af6">6</xref><xref ref-type="aff" rid="af7">7</xref><xref ref-type="aff" rid="af75">75</xref><xref ref-type="author-notes" rid="AN3">#</xref></contrib><contrib contrib-type="author"><name><surname>Jaddoe</surname><given-names>Vincent W.V.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref><xref ref-type="author-notes" rid="AN3">#</xref></contrib><on-behalf-of>for the Early Growth Genetics (EGG) Consortium</on-behalf-of><aff id="af1"><label>1</label><addr-line>The Generation R Study Group</addr-line>,</aff><aff id="af2"><label>2</label><addr-line>Department of Pediatrics</addr-line>,</aff><aff id="af3"><label>3</label><addr-line>Department of Epidemiology</addr-line>,</aff><aff id="af4"><label>4</label><addr-line>Department of Internal Medicine</addr-line>,<institution>Erasmus MC, University Medical Center Rotterdam</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af5"><label>5</label><addr-line>Center for Applied Genomics</addr-line>,</aff><aff id="af6"><label>6</label><addr-line>Division of Human Genetics</addr-line>,</aff><aff id="af7"><label>7</label><addr-line>Division of Endocrinology</addr-line>,</aff><aff id="af8"><label>8</label><addr-line>Division of Gastroenterology, Hepatology and Nutrition</addr-line>,<institution>The Children's Hospital of Philadelphia</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country>,</aff><aff id="af9"><label>9</label><addr-line>Department of Pulmonology, GRIAC (Groningen Research Institute for Asthma and COPD)</addr-line>,</aff><aff id="af10"><label>10</label><addr-line>Department of Genetics</addr-line>,</aff><aff id="af11"><label>11</label><addr-line>Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC (Groningen Research Institute for Asthma and COPD)</addr-line>,<institution>University of Groningen, University Medical Center Groningen</institution>,<addr-line>Groningen</addr-line>,<country>The Netherlands</country>,</aff><aff id="af12"><label>12</label><addr-line>MRC Integrative Epidemiology Unit at the University of Bristol</addr-line>,</aff><aff id="af13"><label>13</label><addr-line>Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine</addr-line>,<institution>University of Bristol</institution>,<addr-line>Bristol</addr-line>,<country>UK</country>,</aff><aff id="af14"><label>14</label><addr-line>Department of Epidemiology Research</addr-line>,<institution>Statens Serum Institut</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</aff><aff id="af15"><label>15</label><institution>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</aff><aff id="af16"><label>16</label><addr-line>Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital</addr-line>,<institution>University of Munich Medical Center</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</aff><aff id="af17"><label>17</label><addr-line>Department of Pediatrics, Naestved Hospital, Naestved, Denmark</addr-line>,</aff><aff id="af18"><label>18</label><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>,</aff><aff id="af19"><label>19</label><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</aff><aff id="af20"><label>20</label><addr-line>Research Centre of Applied and Preventive Cardiovascular Medicine</addr-line>,</aff><aff id="af21"><label>21</label><addr-line>Department of Health and Physical Activity, Paavo Nurmi Centre, Sports and Exercise Medicine Unit</addr-line>,</aff><aff id="af22"><label>22</label><addr-line>Department of Clinical Physiology and Nuclear Medicine</addr-line>,</aff><aff id="af23"><label>23</label><addr-line>Department of Pediatrics</addr-line>,<institution>Turku University Hospital, University of Turku</institution>,<addr-line>Turku</addr-line>,<country>Finland</country>,</aff><aff id="af24"><label>24</label><addr-line>Institute of Clinical Medicine, Neurology</addr-line>,</aff><aff id="af25"><label>25</label><addr-line>Institute of Biomedicine, Physiology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</aff><aff id="af26"><label>26</label><addr-line>Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry</addr-line>,<institution>Queen Mary University of London</institution>,<country>UK</country>,</aff><aff id="af27"><label>27</label><addr-line>Population, Policy and Practice, UCL Institute of Child Health</addr-line>,</aff><aff id="af28"><label>28</label><addr-line>Department of Epidemiology and Public Health</addr-line>,<institution>University College London</institution>,<country>UK</country>,</aff><aff id="af29"><label>29</label><addr-line>Centre for Life Course Epidemiology</addr-line>,</aff><aff id="af30"><label>30</label><addr-line>Institute of Clinical Medicine/Obstetrics and Gynecology</addr-line>,</aff><aff id="af31"><label>31</label><addr-line>Biocenter Oulu</addr-line>,<institution>University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</aff><aff id="af32"><label>32</label><addr-line>Institute of Reproductive and Developmental Biology</addr-line>,</aff><aff id="af33"><label>33</label><addr-line>Section of Investigative Medicine, Division of Diabetes, Endocrinology, and Metabolism, Faculty of Medicine</addr-line>,<institution>Imperial College</institution>,<addr-line>London</addr-line>,<country>UK</country>,</aff><aff id="af34"><label>34</label><addr-line>Department of Biological Psychology</addr-line>,<institution>VU University Amsterdam</institution>,<institution>NCA Neuroscience Campus Amsterdam</institution>,<institution>EMGO+ Institute for Health and Care Research</institution>,<addr-line>Amsterdam</addr-line>,<country>the Netherlands</country>,</aff><aff id="af35"><label>35</label><addr-line>Institute for Molecular Medicine, Finland (FIMM)</addr-line>,<institution>University of Helsinki</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="af36"><label>36</label><addr-line>School of Women's and Infants’ Health</addr-line>,<institution>The University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country>,</aff><aff id="af37"><label>37</label><addr-line>Department of Clinical Chemistry</addr-line>,<institution>Fimlab Laboratories</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</aff><aff id="af38"><label>38</label><addr-line>Department of Clinical Chemistry</addr-line>,</aff><aff id="af39"><label>39</label><addr-line>Department of Clinical Physiology</addr-line>,<institution>University of Tampere School of Medicine</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</aff><aff id="af40"><label>40</label><addr-line>Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair</addr-line>,<institution>University of Manchester</institution> and</aff><aff id="af41"><label>41</label><institution>University Hospital of South Manchester, Manchester Academic Health Sciences Centre</institution>,<addr-line>Manchester</addr-line>,<country>UK</country>,</aff><aff id="af42"><label>42</label><institution>Universidad Miguel Hernandez</institution>,<addr-line>Elche-Alicante</addr-line>,<country>Spain</country>,</aff><aff id="af43"><label>43</label><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>,<country>Spain</country>,</aff><aff id="af44"><label>44</label><addr-line>COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital</addr-line>,</aff><aff id="af45"><label>45</label><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</aff><aff id="af46"><label>46</label><institution>Steno Diabetes Center</institution>,<addr-line>Gentofte</addr-line>,<country>Denmark</country>,</aff><aff id="af47"><label>47</label><addr-line>Department of Genes and Envrionment, Division of Epidemiology</addr-line>,</aff><aff id="af48"><label>48</label><addr-line>Division of Epidemiology</addr-line>,<institution>Norwegian Institute of Public Health</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</aff><aff id="af49"><label>49</label><addr-line>Department of Systems Pharmacology and Translational Therapeutics</addr-line>,<institution>University of Pennsylvania Perelman School of Medicine</institution>,<country>USA</country>,</aff><aff id="af50"><label>50</label><institution>Centre for Research in Environmental Epidemiology (CREAL)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</aff><aff id="af51"><label>51</label><institution>Pompeu Fabra University (UPF)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</aff><aff id="af52"><label>52</label><institution>CNRS UMR8199, Pasteur Institute Lille</institution>,<country>France</country>,</aff><aff id="af53"><label>53</label><institution>European Genomic Institute for Diabetes (EGID)</institution>,<addr-line>Lille</addr-line>,<country>France</country>,</aff><aff id="af54"><label>54</label><addr-line>Department of Health Sciences</addr-line>,<institution>University of Leicester</institution>,<addr-line>Leicester</addr-line>,<country>UK</country>,</aff><aff id="af55"><label>55</label><addr-line>Department of Nutrition and Dietetics, School of Health Science and Education</addr-line>,<institution>Harokopio University</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</aff><aff id="af56"><label>56</label><institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="af57"><label>57</label><addr-line>Center of Pediatric Research, Department of Women’s and Child Health</addr-line>,</aff><aff id="af58"><label>58</label><addr-line>LIFE Child (Leipzig Research Center for Civilization Diseases)</addr-line>,</aff><aff id="af59"><label>59</label><addr-line>CrescNet, Medical Faculty</addr-line>,<institution>University of Leipzig</institution>,<country>Germany</country>,</aff><aff id="af60"><label>60</label><addr-line>Department of Psychology</addr-line>,<institution>University of Warwick</institution>,<country>UK</country>,</aff><aff id="af61"><label>61</label><addr-line>Division of Endocrinology and Center for Basic and Translational Obesity Research</addr-line>,<institution>Boston Children's Hospital</institution>,<addr-line>Boston</addr-line>,<country>USA</country>,</aff><aff id="af62"><label>62</label><addr-line>Medical and Population Genetics Program</addr-line>,<institution>Broad Institute of MIT and Harvard</institution>,<addr-line>Cambridge</addr-line>,<country>USA</country>,</aff><aff id="af63"><label>63</label><addr-line>Department of Genetics</addr-line>,<institution>Harvard Medical School</institution>,<addr-line>Boston</addr-line>,<country>USA</country>,</aff><aff id="af64"><label>64</label><addr-line>The Children's Obesity Clinic, Department of Pediatrics</addr-line>,<institution>Copenhagen University Hospital Holbæk, The Danish Childhood Obesity Biobank</institution>,<country>Denmark</country>,</aff><aff id="af65"><label>65</label><institution>Institute of Medicine, Copenhagen University,</institution><addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</aff><aff id="af66"><label>66</label><addr-line>State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology</addr-line>,<institution>Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</aff><aff id="af67"><label>67</label><addr-line>Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Frederiksberg C</addr-line>,<country>Denmark</country>,</aff><aff id="af68"><label>68</label><addr-line>Department of Clinical Physiology</addr-line>,<institution>Tampere University Hospital</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</aff><aff id="af69"><label>69</label><institution>Kuopio Research Institute of Exercise Medicine</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</aff><aff id="af70"><label>70</label><addr-line>Department of Clinical Physiology and Nuclear Medicine</addr-line>,<institution>Kuopio University Hospital</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</aff><aff id="af71"><label>71</label><addr-line>Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<country>UK</country>,</aff><aff id="af72"><label>72</label><addr-line>Department of Epidemiology</addr-line>,</aff><aff id="af73"><label>73</label><addr-line>Department of Biostatistics</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country>,</aff><aff id="af74"><label>74</label><addr-line>College of Information Science and Technology</addr-line>,<institution>Dalian Maritime University</institution>,<addr-line>Dalian, Liaoning Province</addr-line>,<country>China</country>,</aff><aff id="af75"><label>75</label><addr-line>Department of Pediatrics, Perelman School of Medicine</addr-line>,<institution>University of Pennsylvania</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country>,</aff><aff id="af76"><label>76</label><addr-line>Department of Obstetrics and Gynecology, Sahlgrenska Academy</addr-line>,<institution>Sahlgrenska University Hosptial</institution>,<addr-line>Gothenburg</addr-line>,<country>Sweden</country>,</aff><aff id="af77"><label>77</label><institution>Area de Salut de Menorca, ib-salut</institution>,<addr-line>Menorca</addr-line>,<country>Spain</country>,</aff><aff id="af78"><label>78</label><institution>Wellcome Trust Sanger Institute, The Morgan Building, Wellcome Trust Genome Campus</institution>,<addr-line>Hinxton, Cambridgeshire</addr-line>,<country>UK</country>,</aff><aff id="af79"><label>79</label><addr-line>Department of Genomics of Common Disease</addr-line>,<institution>School of Public Health, Imperial College London, Hammersmith Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country>,</aff><aff id="af80"><label>80</label><institution>IMIM (Hospital del Mar Medical Research Institute)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</aff><aff id="af81"><label>81</label><addr-line>King's College London, MRC Social, Genetic and Developmental Psychiatry Centre</addr-line>,<institution>Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park</institution>,<addr-line>London</addr-line>,<country>UK</country>,</aff><aff id="af82"><label>82</label><addr-line>Unit of Primary Care</addr-line>,<institution>Oulu University Hospital</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</aff><aff id="af83"><label>83</label><addr-line>Department of Children and Young People and Families</addr-line>,<institution>National Institute for Health and Welfare</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</aff><aff id="af84"><label>84</label><institution>School of Population Health and Sansom Institute</institution>,<institution>University of South Australia</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</aff><aff id="af85"><label>85</label><institution>South Australian Health and Medical Research Institute</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</aff><aff id="af86"><label>86</label><institution>Oxford National Institute for Health Research (NIHR) Biomedical Research Centre, Churchill Hospital</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</aff><aff id="af87"><label>87</label><addr-line>Department of Medicine</addr-line>,<institution>Stanford University School of Medicine</institution>,<addr-line>Stanford, CA</addr-line>,<country>USA</country> and</aff><aff id="af88"><label>88</label><addr-line>Institute of Preventive Medicine</addr-line>,<institution>Bispebjerg and Frederiksberg Hospital, The Capital Region</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country></aff></contrib-group><contrib-group><contrib contrib-type="collab"><collab>Bone Mineral Density in Childhood Study (BMDCS) Consortium</collab></contrib><contrib contrib-type="collab"><name><surname>Kalkwarf</surname><given-names>Heidi J.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Lappe</surname><given-names>Joan M.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Gilsanz</surname><given-names>Vicente</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Oberfield</surname><given-names>Sharon E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Shepherd</surname><given-names>John A.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Kelly</surname><given-names>Andrea</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Zemel</surname><given-names>Babette S.</given-names></name></contrib></contrib-group><author-notes><corresp id="cor1"><label>*</label>To whom correspondence should be addressed at: Department of Epidemiology, Room Na-2906, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Tel: +<phone>31 107043997</phone>; Fax: +<fax>31 107044657</fax>; Email: <email>j.felix@erasmusmc.nl</email></corresp><fn fn-type="con" id="AN1"><label>†</label><p>These first authors contributed equally.</p></fn><fn fn-type="con" id="AN2"><label>‡</label><p>See Appendix for members of the BMDCS consortium.</p></fn><fn fn-type="con" id="AN3"><label>#</label><p>These last authors contributed equally.</p></fn></author-notes><pub-date pub-type="ppub"><day>15</day><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>24</day><month>11</month><year>2015</year></pub-date><volume>25</volume><issue>2</issue><fpage>389</fpage><lpage>403</lpage><history><date date-type="received"><day>3</day><month>6</month><year>2015</year></date><date date-type="rev-recd"><day>11</day><month>10</month><year>2015</year></date><date date-type="accepted"><day>15</day><month>11</month><year>2015</year></date></history><permissions><copyright-statement>© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2015</copyright-year></permissions><self-uri content-type="pdf" xlink:href="ddv472.pdf"></self-uri><abstract><p>A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (<italic>P</italic>-value < 5 × 10<sup>−8</sup>) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to <italic>ADCY3</italic>, <italic>GNPDA2</italic>, <italic>TMEM18</italic>, <italic>SEC16B</italic>, <italic>FAIM2</italic>, <italic>FTO</italic>, <italic>TFAP2B</italic>, <italic>TNNI3K</italic>, <italic>MC4R</italic>, <italic>GPR61, LMX1B</italic> and <italic>OLFM4</italic> associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near <italic>ELP3</italic>, rs8092503 near <italic>RAB27B</italic> and rs13387838 near <italic>ADAM23</italic>. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, <italic>P</italic>-value = 3.12 × 10<sup>−10</sup>) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in strength of the associations with body mass index.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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