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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration</title><author><name sortKey="De Vries, Paul S" sort="De Vries, Paul S" uniqKey="De Vries P" first="Paul S." last="De Vries">Paul S. De Vries</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="af4"><addr-line>Division of Preventive Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af5"><institution>Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Sabater Lleal, Maria" sort="Sabater Lleal, Maria" uniqKey="Sabater Lleal M" first="Maria" last="Sabater-Lleal">Maria Sabater-Lleal</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name><affiliation><nlm:aff id="af8"><addr-line>Department of Neurology</addr-line>,<institution>Boston University School of Medicine</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af9"><addr-line>Framingham Heart Study, Population Sciences Branch</addr-line>,<institution>Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health</institution>,<addr-line>Framingham, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E." last="Huffman">Jennifer E. Huffman</name><affiliation><nlm:aff id="af9"><addr-line>Framingham Heart Study, Population Sciences Branch</addr-line>,<institution>Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health</institution>,<addr-line>Framingham, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af10"><addr-line>MRC Human Genetics Unit</addr-line>,<institution>Institute of Genetics and Molecular Medicine</institution>,</nlm:aff></affiliation></author><author><name sortKey="Steri, Maristella" sort="Steri, Maristella" uniqKey="Steri M" first="Maristella" last="Steri">Maristella Steri</name><affiliation><nlm:aff id="af17"><institution>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche</institution>,<addr-line>Monserrato, Cagliari</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name><affiliation><nlm:aff wicri:cut=" and" id="af18"><addr-line>Division of Epidemiology and Community Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="af20"><addr-line>Institute for Community Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Marioni, Riccardo E" sort="Marioni, Riccardo E" uniqKey="Marioni R" first="Riccardo E." last="Marioni">Riccardo E. Marioni</name><affiliation><nlm:aff id="af11"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af12"><addr-line>Centre for Genomic and Experimental Medicine</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af24"><addr-line>Queensland Brain Institute</addr-line>,<institution>University of Queensland</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Grossmann, Vera" sort="Grossmann, Vera" uniqKey="Grossmann V" first="Vera" last="Grossmann">Vera Grossmann</name><affiliation><nlm:aff id="af25"><addr-line>Center for Thrombosis and Hemostasis (CTH)</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke J" sort="Hottenga, Jouke J" uniqKey="Hottenga J" first="Jouke J." last="Hottenga">Jouke J. Hottenga</name><affiliation><nlm:aff id="af28"><addr-line>Department of Biological Psychology, Netherlands Twin Register</addr-line>,<institution>VU University</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation><nlm:aff id="af29"><addr-line>Department of Cardiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Department of Gerontology and Geriatrics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation><nlm:aff id="af32"><addr-line>Institute of Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af35"><addr-line>Department of Medicine I</addr-line>,<institution>Ludwig-Maximilians-University Munich</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af36"><addr-line>DZHK (German Centre for Cardiovascular Research)</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="af38"><addr-line>MRC Epidemiology Unit</addr-line>,<institution>School of Clinical Medicine</institution> and,</nlm:aff></affiliation></author><author><name sortKey="Brody, Jennifer A" sort="Brody, Jennifer A" uniqKey="Brody J" first="Jennifer A." last="Brody">Jennifer A. Brody</name><affiliation><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><affiliation><nlm:aff id="af44"><addr-line>Vth Department of Medicine, Medical Faculty Mannheim</addr-line>,<institution>Heidelberg University</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Guo, Xiuqing" sort="Guo, Xiuqing" uniqKey="Guo X" first="Xiuqing" last="Guo">Xiuqing Guo</name><affiliation><nlm:aff wicri:cut=" and" id="af45"><addr-line>Institute for Translational Genomics and Population Sciences</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af46"><addr-line>Department of Pediatrics</addr-line>,<institution>Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center</institution>,<addr-line>Torrance, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation><nlm:aff id="af47"><addr-line>Department of Ophthalmology</addr-line>,<institution>Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Auer, Paul L" sort="Auer, Paul L" uniqKey="Auer P" first="Paul L." last="Auer">Paul L. Auer</name><affiliation><nlm:aff id="af48"><addr-line>Zilber School of Public Health</addr-line>,<institution>University of Wisconsin-Milwaukee</institution>,<addr-line>Milwaukee, WI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Attia, John R" sort="Attia, John R" uniqKey="Attia J" first="John R." last="Attia">John R. Attia</name><affiliation><nlm:aff wicri:cut=" and" id="af49"><addr-line>Public Health Stream</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af51"><addr-line>School of Medicine and Public Health</addr-line><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Yanek, Lisa R" sort="Yanek, Lisa R" uniqKey="Yanek L" first="Lisa R." last="Yanek">Lisa R. Yanek</name><affiliation><nlm:aff id="af53"><addr-line>Department of Medicine</addr-line>,<institution>Johns Hopkins University School of Medicine</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ahluwalia, Tarunveer S" sort="Ahluwalia, Tarunveer S" uniqKey="Ahluwalia T" first="Tarunveer S." last="Ahluwalia">Tarunveer S. Ahluwalia</name><affiliation><nlm:aff id="af54"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line><country>and</country></nlm:aff></affiliation><affiliation><nlm:aff id="af55"><addr-line>Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af56"><addr-line>The Danish Pediatric Asthma Center</addr-line>,<institution>Gentofte Hospital, The Capital Region</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation><nlm:aff id="af57"><addr-line>Institute of Behavioural Sciences</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af60"><institution>Folkhälsan Research Centre</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation><nlm:aff id="af61"><addr-line>Institute of Opthalmology</addr-line>,<institution>UCL</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af62"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>Kings College London</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="af63"><addr-line>Translational Gerontology Branch</addr-line>,<institution>National Institute on Aging</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Bielak, Lawrence F" sort="Bielak, Lawrence F" uniqKey="Bielak L" first="Lawrence F." last="Bielak">Lawrence F. Bielak</name><affiliation><nlm:aff id="af64"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><affiliation><nlm:aff id="af13"><addr-line>Centre for Population Health Sciences</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation><affiliation><nlm:aff id="af14"><addr-line>Centre for Global Health Research</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation></author><author><name sortKey="Rocanin Arjo, Ares" sort="Rocanin Arjo, Ares" uniqKey="Rocanin Arjo A" first="Ares" last="Rocanin-Arjo">Ares Rocanin-Arjo</name><affiliation><nlm:aff id="af65"><institution>Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af66"><institution>Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af67"><institution>Institute for Cardiometabolism and Nutrition (ICAN)</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:aff id="af68"><addr-line>Department of Public Health, Faculty of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation><nlm:aff id="af10"><addr-line>MRC Human Genetics Unit</addr-line>,<institution>Institute of Genetics and Molecular Medicine</institution>,</nlm:aff></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M." last="Rose">Lynda M. Rose</name><affiliation><nlm:aff id="af4"><addr-line>Division of Preventive Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Oldmeadow, Christopher" sort="Oldmeadow, Christopher" uniqKey="Oldmeadow C" first="Christopher" last="Oldmeadow">Christopher Oldmeadow</name><affiliation><nlm:aff wicri:cut=" and" id="af49"><addr-line>Public Health Stream</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af51"><addr-line>School of Medicine and Public Health</addr-line><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Riess, Helene" sort="Riess, Helene" uniqKey="Riess H" first="Helene" last="Riess">Helene Riess</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Institute of Epidemiology II</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mazur, Johanna" sort="Mazur, Johanna" uniqKey="Mazur J" first="Johanna" last="Mazur">Johanna Mazur</name><affiliation><nlm:aff wicri:cut=" and" id="af26"><addr-line>Institute of Medical Biostatistics, Epidemiology and Informatics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name><affiliation><nlm:aff id="af19"><addr-line>Division of Biostatistics</addr-line>,<institution>University of Minnesota</institution>,<addr-line>Minneapolis, MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:aff id="af71"><addr-line>Cardiovascular Medicine Department/Radcliffe Department of Medicine</addr-line>,<institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation><nlm:aff id="af9"><addr-line>Framingham Heart Study, Population Sciences Branch</addr-line>,<institution>Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health</institution>,<addr-line>Framingham, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af72"><addr-line>Department of Biostatistics</addr-line>,<institution>Boston University School of Public Health</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ghanbari, Mohsen" sort="Ghanbari, Mohsen" uniqKey="Ghanbari M" first="Mohsen" last="Ghanbari">Mohsen Ghanbari</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af73"><addr-line>Department of Genetics</addr-line>,<institution>School of Medicine, Mashhad University of Medical Sciences</institution>,<addr-line>Mashhad</addr-line>,<country>Iran</country>,</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="af28"><addr-line>Department of Biological Psychology, Netherlands Twin Register</addr-line>,<institution>VU University</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name><affiliation><nlm:aff id="af74"><addr-line>Institute of Cardiovascular and Medical Sciences</addr-line><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Fiorillo, Edoardo" sort="Fiorillo, Edoardo" uniqKey="Fiorillo E" first="Edoardo" last="Fiorillo">Edoardo Fiorillo</name><affiliation><nlm:aff id="af17"><institution>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche</institution>,<addr-line>Monserrato, Cagliari</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J. M." last="De Craen">Anton J. M. De Craen</name><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Department of Gerontology and Geriatrics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Grotevendt, Anne" sort="Grotevendt, Anne" uniqKey="Grotevendt A" first="Anne" last="Grotevendt">Anne Grotevendt</name><affiliation><nlm:aff id="af21"><addr-line>Institute of Clinical Chemistry and Laboratory Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation><nlm:aff id="af38"><addr-line>MRC Epidemiology Unit</addr-line>,<institution>School of Clinical Medicine</institution> and,</nlm:aff></affiliation></author><author><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D." last="Taylor">Kent D. Taylor</name><affiliation><nlm:aff wicri:cut=" and" id="af45"><addr-line>Institute for Translational Genomics and Population Sciences</addr-line></nlm:aff></affiliation></author><author><name sortKey="Delgado, Graciela E" sort="Delgado, Graciela E" uniqKey="Delgado G" first="Graciela E." last="Delgado">Graciela E. Delgado</name><affiliation><nlm:aff id="af44"><addr-line>Vth Department of Medicine, Medical Faculty Mannheim</addr-line>,<institution>Heidelberg University</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Yao, Jie" sort="Yao, Jie" uniqKey="Yao J" first="Jie" last="Yao">Jie Yao</name><affiliation><nlm:aff wicri:cut=" and" id="af45"><addr-line>Institute for Translational Genomics and Population Sciences</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kifley, Annette" sort="Kifley, Annette" uniqKey="Kifley A" first="Annette" last="Kifley">Annette Kifley</name><affiliation><nlm:aff id="af47"><addr-line>Department of Ophthalmology</addr-line>,<institution>Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation><nlm:aff id="af76"><institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Qayyum, Rehan" sort="Qayyum, Rehan" uniqKey="Qayyum R" first="Rehan" last="Qayyum">Rehan Qayyum</name><affiliation><nlm:aff id="af53"><addr-line>Department of Medicine</addr-line>,<institution>Johns Hopkins University School of Medicine</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation><nlm:aff id="af11"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af77"><addr-line>Department of Psychiatry</addr-line>,<institution>Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital</institution>,<addr-line>Dublin</addr-line>,<country>Ireland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af78"><institution>University College Dublin, UCD Conway Institute, Centre for Proteome Research, UCD</institution>,<addr-line>Belfield, Dublin</addr-line>,<country>Ireland</country>,</nlm:aff></affiliation></author><author><name sortKey="Berentzen, Tina L" sort="Berentzen, Tina L" uniqKey="Berentzen T" first="Tina L." last="Berentzen">Tina L. Berentzen</name><affiliation><nlm:aff id="af79"><addr-line>Institute of Preventive Medicine</addr-line>,<institution>Bispebjerg and Frederiksberg Hospital, The Capital Region</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation><nlm:aff id="af57"><addr-line>Institute of Behavioural Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="af62"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>Kings College London</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="af80"><addr-line>Geriatric Unit</addr-line>,<institution>Azienda Sanitaria Firenze (ASF)</institution>,<addr-line>Florence</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Peyser, Patricia A" sort="Peyser, Patricia A" uniqKey="Peyser P" first="Patricia A." last="Peyser">Patricia A. Peyser</name><affiliation><nlm:aff id="af64"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah" sort="Wild, Sarah" uniqKey="Wild S" first="Sarah" last="Wild">Sarah Wild</name><affiliation><nlm:aff id="af13"><addr-line>Centre for Population Health Sciences</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation></author><author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Trégouët">David-Alexandre Trégouët</name><affiliation><nlm:aff id="af65"><institution>Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af66"><institution>Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af67"><institution>Institute for Cardiometabolism and Nutrition (ICAN)</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="af10"><addr-line>MRC Human Genetics Unit</addr-line>,<institution>Institute of Genetics and Molecular Medicine</institution>,</nlm:aff></affiliation></author><author><name sortKey="Marten, Jonathan" sort="Marten, Jonathan" uniqKey="Marten J" first="Jonathan" last="Marten">Jonathan Marten</name><affiliation><nlm:aff id="af10"><addr-line>MRC Human Genetics Unit</addr-line>,<institution>Institute of Genetics and Molecular Medicine</institution>,</nlm:aff></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation><nlm:aff id="af69"><addr-line>Department of Biology, School of Medicine</addr-line><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C." last="Morrison">Alanna C. Morrison</name><affiliation><nlm:aff id="af81"><addr-line>Human Genetics Center</addr-line>,<institution>University of Texas Health Science Center at Houston</institution>,<addr-line>Houston, TX</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af7"><addr-line>Science for Life Laboratory</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Tofler, Geoffrey" sort="Tofler, Geoffrey" uniqKey="Tofler G" first="Geoffrey" last="Tofler">Geoffrey Tofler</name><affiliation><nlm:aff id="af82"><addr-line>Royal North Shore Hospital</addr-line>,<institution>Sydney University</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="De Maat, Moniek P M" sort="De Maat, Moniek P M" uniqKey="De Maat M" first="Moniek P. M." last="De Maat">Moniek P. M. De Maat</name><affiliation><nlm:aff id="af2"><addr-line>Department of Hematology</addr-line> and,</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation><nlm:aff id="af28"><addr-line>Department of Biological Psychology, Netherlands Twin Register</addr-line>,<institution>VU University</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af83"><addr-line>EMGO+ institute</addr-line>,<institution>VU University & VU Medical Center</institution>,<addr-line>Amsterdam</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lowe, Gordon D" sort="Lowe, Gordon D" uniqKey="Lowe G" first="Gordon D." last="Lowe">Gordon D. Lowe</name><affiliation><nlm:aff id="af74"><addr-line>Institute of Cardiovascular and Medical Sciences</addr-line><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Zoledziewska, Magdalena" sort="Zoledziewska, Magdalena" uniqKey="Zoledziewska M" first="Magdalena" last="Zoledziewska">Magdalena Zoledziewska</name><affiliation><nlm:aff id="af17"><institution>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche</institution>,<addr-line>Monserrato, Cagliari</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation><nlm:aff id="af84"><addr-line>Faculty of Medicine</addr-line>,<institution>BHF Glasgow Cardiovascular Research Centre</institution>,<addr-line>Glasgow</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Binder, Harald" sort="Binder, Harald" uniqKey="Binder H" first="Harald" last="Binder">Harald Binder</name><affiliation><nlm:aff wicri:cut=" and" id="af26"><addr-line>Institute of Medical Biostatistics, Epidemiology and Informatics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:aff wicri:cut=" and" id="af22"><addr-line>Interfaculty Institute for Genetics and Functional Genomics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Institute of Epidemiology II</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af34"><addr-line>Research Unit of Molecular Epidemiology</addr-line>,<institution>Helmholtz ZentrumMünchen – German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="af39"><addr-line>Clinical Gerontology Unit</addr-line>,<institution>School of Clinical Medicine, University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:aff id="af41"><addr-line>Department of Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name><affiliation><nlm:aff id="af85"><addr-line>Department of Human Genetics</addr-line>,<institution>Wellcome Trust Sanger Institute</institution>,<addr-line>Hinxton, Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Jenny, Nancy S" sort="Jenny, Nancy S" uniqKey="Jenny N" first="Nancy S." last="Jenny">Nancy S. Jenny</name><affiliation><nlm:aff id="af86"><addr-line>Department of Pathology and Laboratory Medicine</addr-line><country>and</country>,</nlm:aff></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation><nlm:aff id="af88"><addr-line>Public Health Stream</addr-line>,<institution>Hunter Medical Research Institute, School of Medicine and Public Health</institution><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Qi, Lihong" sort="Qi, Lihong" uniqKey="Qi L" first="Lihong" last="Qi">Lihong Qi</name><affiliation><nlm:aff id="af90"><addr-line>Division of Biostatistics, Department of Public Health Sciences</addr-line>,<institution>UC Davis</institution>,<addr-line>Davis, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Mcevoy, Mark G" sort="Mcevoy, Mark G" uniqKey="Mcevoy M" first="Mark G." last="Mcevoy">Mark G. Mcevoy</name><affiliation><nlm:aff id="af89"><addr-line>School of Medicine and Public Health</addr-line>,<institution>University of Newcastle</institution>,<addr-line>Newcastle</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Becker, Diane M" sort="Becker, Diane M" uniqKey="Becker D" first="Diane M." last="Becker">Diane M. Becker</name><affiliation><nlm:aff id="af53"><addr-line>Department of Medicine</addr-line>,<institution>Johns Hopkins University School of Medicine</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation><nlm:aff id="af11"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Alzheimer Scotland Dementia Research Centre</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sarin, Antti Pekka" sort="Sarin, Antti Pekka" uniqKey="Sarin A" first="Antti-Pekka" last="Sarin">Antti-Pekka Sarin</name><affiliation><nlm:aff wicri:cut=" and" id="af58"><addr-line>Institute for Molecular Medicine Finland (FIMM)</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af91"><addr-line>Public Health Genomics Unit</addr-line>,<institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><affiliation><nlm:aff id="af62"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>Kings College London</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena G." last="Hernandez">Dena G. Hernandez</name><affiliation><nlm:aff id="af92"><addr-line>Laboratory of Neurogenetics</addr-line>,<institution>National Institute on Aging</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Jhun, Min A" sort="Jhun, Min A" uniqKey="Jhun M" first="Min A." last="Jhun">Min A. Jhun</name><affiliation><nlm:aff id="af64"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="af14"><addr-line>Centre for Global Health Research</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Internal Medicine</addr-line>,<institution>Erasmus MC</institution>,<addr-line>Wytemaweg 80</addr-line>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="af93"><addr-line>School of Social and Community Medicine</addr-line>,<institution>University of Bristol</institution>,<addr-line>Bristol</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P. Eline" last="Slagboom">P. Eline Slagboom</name><affiliation><nlm:aff id="af31"><addr-line>Department of Molecular Epidemiology</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation><nlm:aff id="af94"><addr-line>Department of General and Interventional Cardiology</addr-line>,<institution>University Heart Centre, University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af95"><institution>German Center for Cardiovascular Research (DZHK), Partner Site Hamburg</institution>,<addr-line>Lübeck, Kiel, Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation><nlm:aff id="af37"><addr-line>German Centre for Cardiovascular Research (DZHK)</addr-line>,<institution>Partner Site Munich Heart Alliance</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af96"><addr-line>Department of Internal Medicine II – Cardiology</addr-line>,<institution>University of Ulm Medical Centre</institution>,<addr-line>Ulm</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af97"><addr-line>Deutsches Herzzentrum München</addr-line>,<institution>Technische Universität München</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff wicri:cut=" and" id="af42"><addr-line>Department of Medicine, Epidemiology, and Health Services</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af98"><institution>Group Health Research Institute, Group Health Cooperative</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Haritunians, Talin" sort="Haritunians, Talin" uniqKey="Haritunians T" first="Talin" last="Haritunians">Talin Haritunians</name><affiliation><nlm:aff id="af99"><addr-line>Inflammatory Bowel & Immunobiology Research Institute</addr-line>,<institution>Cedars-Sinai Medical Center</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Liu, Jingmin" sort="Liu, Jingmin" uniqKey="Liu J" first="Jingmin" last="Liu">Jingmin Liu</name><affiliation><nlm:aff id="af76"><institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:aff wicri:cut=" and" id="af58"><addr-line>Institute for Molecular Medicine Finland (FIMM)</addr-line></nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Internal Medicine</addr-line>,<institution>Erasmus MC</institution>,<addr-line>Wytemaweg 80</addr-line>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J." last="Stott">David J. Stott</name><affiliation><nlm:aff id="af75"><addr-line>Institute of Cardiovascular and Medical Sciences</addr-line>,<institution>Faculty of Medicine, University of Glasgow</institution>,<addr-line>Glasgow</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="af14"><addr-line>Centre for Global Health Research</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation><affiliation><nlm:aff id="af70"><addr-line>Department of Public Health</addr-line>,<addr-line>Faculty of Medicine</addr-line>,<institution>Centre for Global Health, University of Split</institution>,<addr-line>Split</addr-line>,<country>Croatia</country>,</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="af14"><addr-line>Centre for Global Health Research</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation></author><author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name><affiliation><nlm:aff id="af100"><addr-line>Laboratory of Haematology</addr-line>,<institution>La Timone Hospital</institution>,<addr-line>Marseille F-13385</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af101"><institution>INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis</institution>,<addr-line>Marseille F-13385</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af102"><institution>Aix-Marseille University, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis</institution>,<addr-line>Marseille F-13385</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="af10"><addr-line>MRC Human Genetics Unit</addr-line>,<institution>Institute of Genetics and Molecular Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff id="af14"><addr-line>Centre for Global Health Research</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name><affiliation><nlm:aff id="af64"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="af63"><addr-line>Translational Gerontology Branch</addr-line>,<institution>National Institute on Aging</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="af62"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>Kings College London</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="af59"><addr-line>Department of General Practice and Primary Health Care</addr-line>,<institution>University of Helsinki</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af60"><institution>Folkhälsan Research Centre</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af103"><institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af104"><addr-line>Unit of General Practice</addr-line>,<institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation><nlm:aff id="af54"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation><nlm:aff id="af11"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af16"><addr-line>Department of Psychology</addr-line>,<institution>University of Edinburgh</institution>,<addr-line>Edinburgh</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Becker, Lewis C" sort="Becker, Lewis C" uniqKey="Becker L" first="Lewis C." last="Becker">Lewis C. Becker</name><affiliation><nlm:aff id="af53"><addr-line>Department of Medicine</addr-line>,<institution>Johns Hopkins University School of Medicine</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation><nlm:aff id="af50"><addr-line>Information based Medicine Program</addr-line>,<institution>Hunter Medical Research Institute</institution>,<addr-line>New Lambton Heights</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af52"><addr-line>School of Biomedical Sciences and Pharmacy</addr-line>,<institution>University of Newcastle</institution>,<addr-line>New Lambton Heights</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation><nlm:aff id="af47"><addr-line>Department of Ophthalmology</addr-line>,<institution>Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation><nlm:aff id="af44"><addr-line>Vth Department of Medicine, Medical Faculty Mannheim</addr-line>,<institution>Heidelberg University</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af105"><addr-line>Synlab Academy</addr-line>,<institution>Synlab Services LLC</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af106"><addr-line>Clinical Institute of Medical</addr-line>,<addr-line>Chemical Laboratory Diagnostics</addr-line>,<institution>Medical University of Graz</institution>,<addr-line>Graz</addr-line>,<country>Austria</country>,</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J." last="Wareham">Nick J. Wareham</name><affiliation><nlm:aff id="af38"><addr-line>MRC Epidemiology Unit</addr-line>,<institution>School of Clinical Medicine</institution> and,</nlm:aff></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Institute of Epidemiology II</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af36"><addr-line>DZHK (German Centre for Cardiovascular Research)</addr-line></nlm:aff></affiliation></author><author><name sortKey="Greinacher, Andreas" sort="Greinacher, Andreas" uniqKey="Greinacher A" first="Andreas" last="Greinacher">Andreas Greinacher</name><affiliation><nlm:aff id="af23"><addr-line>Institute for Immunology and Transfusion Medicine</addr-line>,<institution>University Medicine Greifswald</institution>,<addr-line>Greifswald</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S." last="Wild">Philipp S. Wild</name><affiliation><nlm:aff id="af25"><addr-line>Center for Thrombosis and Hemostasis (CTH)</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af27"><addr-line>Preventive Cardiology and Preventive Medicine, Department of Medicine 2</addr-line>,<institution>University Medical Center of the Johannes Gutenberg University Mainz</institution>,<addr-line>Mainz</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af107"><addr-line>German Center for Cardiovascular Research (DZHK)</addr-line>,<institution>Partner Site RheinMain</institution>,<addr-line>Mainz</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><affiliation><nlm:aff id="af29"><addr-line>Department of Cardiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af108"><institution>Durrer Center for Cardiogenetic Research</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af109"><institution>Interuniversity Cardiology Institute of The Netherlands</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="af28"><addr-line>Department of Biological Psychology, Netherlands Twin Register</addr-line>,<institution>VU University</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="af10"><addr-line>MRC Human Genetics Unit</addr-line>,<institution>Institute of Genetics and Molecular Medicine</institution>,</nlm:aff></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation><nlm:aff id="af17"><institution>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche</institution>,<addr-line>Monserrato, Cagliari</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Tracy, Russell" sort="Tracy, Russell" uniqKey="Tracy R" first="Russell" last="Tracy">Russell Tracy</name><affiliation><nlm:aff id="af87"><addr-line>Department of Pathology and Laboratory Medicine</addr-line>,<institution>Center for Clinical and Translational Sciences, University of Vermont College of Medicine</institution>,<addr-line>Colchester, VT</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="af71"><addr-line>Cardiovascular Medicine Department/Radcliffe Department of Medicine</addr-line>,<institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P." last="Reiner">Alex P. Reiner</name><affiliation><nlm:aff id="af76"><institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af110"><institution>University of Washington</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><affiliation><nlm:aff wicri:cut=" and" id="af18"><addr-line>Division of Epidemiology and Community Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="af4"><addr-line>Division of Preventive Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af5"><institution>Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name><affiliation><nlm:aff id="af9"><addr-line>Framingham Heart Study, Population Sciences Branch</addr-line>,<institution>Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health</institution>,<addr-line>Framingham, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af111"><institution>National Heart, Lung and Blood Institute, Division of Intramural Research</institution>,</nlm:aff></affiliation><affiliation><nlm:aff id="af112"><addr-line>Cardiology Division</addr-line>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name><affiliation><nlm:aff id="af43"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Washington</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af75"><addr-line>Institute of Cardiovascular and Medical Sciences</addr-line>,<institution>Faculty of Medicine, University of Glasgow</institution>,<addr-line>Glasgow</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af113"><addr-line>Department of Veterans Affairs</addr-line>,<institution>Office of Research and Development, Seattle Epidemiologic Research and Information Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="af114"><addr-line>Population Health Research Institute, St George's</addr-line><institution>University of London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26561523</idno><idno type="pmc">4715256</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715256</idno><idno type="RBID">PMC:4715256</idno><idno type="doi">10.1093/hmg/ddv454</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000441</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000441</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration</title><author><name sortKey="De Vries, Paul S" sort="De Vries, Paul S" uniqKey="De Vries P" first="Paul S." last="De Vries">Paul S. De Vries</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="af4"><addr-line>Division of Preventive Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af5"><institution>Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Sabater Lleal, Maria" sort="Sabater Lleal, Maria" uniqKey="Sabater Lleal M" first="Maria" last="Sabater-Lleal">Maria Sabater-Lleal</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name><affiliation><nlm:aff id="af8"><addr-line>Department of Neurology</addr-line>,<institution>Boston University School of Medicine</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af9"><addr-line>Framingham Heart Study, Population Sciences Branch</addr-line>,<institution>Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health</institution>,<addr-line>Framingham, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E." last="Huffman">Jennifer E. Huffman</name><affiliation><nlm:aff id="af9"><addr-line>Framingham Heart Study, Population Sciences Branch</addr-line>,<institution>Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health</institution>,<addr-line>Framingham, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af10"><addr-line>MRC Human Genetics Unit</addr-line>,<institution>Institute of Genetics and Molecular Medicine</institution>,</nlm:aff></affiliation></author><author><name sortKey="Steri, Maristella" sort="Steri, Maristella" uniqKey="Steri M" first="Maristella" last="Steri">Maristella Steri</name><affiliation><nlm:aff id="af17"><institution>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche</institution>,<addr-line>Monserrato, Cagliari</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name><affiliation><nlm:aff wicri:cut=" and" id="af18"><addr-line>Division of Epidemiology and Community Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="af20"><addr-line>Institute for Community Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Marioni, Riccardo E" sort="Marioni, Riccardo E" uniqKey="Marioni R" first="Riccardo E." last="Marioni">Riccardo E. Marioni</name><affiliation><nlm:aff id="af11"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af12"><addr-line>Centre for Genomic and Experimental Medicine</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af24"><addr-line>Queensland Brain Institute</addr-line>,<institution>University of Queensland</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Grossmann, Vera" sort="Grossmann, Vera" uniqKey="Grossmann V" first="Vera" last="Grossmann">Vera Grossmann</name><affiliation><nlm:aff id="af25"><addr-line>Center for Thrombosis and Hemostasis (CTH)</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke J" sort="Hottenga, Jouke J" uniqKey="Hottenga J" first="Jouke J." last="Hottenga">Jouke J. Hottenga</name><affiliation><nlm:aff id="af28"><addr-line>Department of Biological Psychology, Netherlands Twin Register</addr-line>,<institution>VU University</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation><nlm:aff id="af29"><addr-line>Department of Cardiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Department of Gerontology and Geriatrics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation><nlm:aff id="af32"><addr-line>Institute of Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af35"><addr-line>Department of Medicine I</addr-line>,<institution>Ludwig-Maximilians-University Munich</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af36"><addr-line>DZHK (German Centre for Cardiovascular Research)</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="af38"><addr-line>MRC Epidemiology Unit</addr-line>,<institution>School of Clinical Medicine</institution> and,</nlm:aff></affiliation></author><author><name sortKey="Brody, Jennifer A" sort="Brody, Jennifer A" uniqKey="Brody J" first="Jennifer A." last="Brody">Jennifer A. Brody</name><affiliation><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><affiliation><nlm:aff id="af44"><addr-line>Vth Department of Medicine, Medical Faculty Mannheim</addr-line>,<institution>Heidelberg University</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Guo, Xiuqing" sort="Guo, Xiuqing" uniqKey="Guo X" first="Xiuqing" last="Guo">Xiuqing Guo</name><affiliation><nlm:aff wicri:cut=" and" id="af45"><addr-line>Institute for Translational Genomics and Population Sciences</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af46"><addr-line>Department of Pediatrics</addr-line>,<institution>Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center</institution>,<addr-line>Torrance, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation><nlm:aff id="af47"><addr-line>Department of Ophthalmology</addr-line>,<institution>Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Auer, Paul L" sort="Auer, Paul L" uniqKey="Auer P" first="Paul L." last="Auer">Paul L. Auer</name><affiliation><nlm:aff id="af48"><addr-line>Zilber School of Public Health</addr-line>,<institution>University of Wisconsin-Milwaukee</institution>,<addr-line>Milwaukee, WI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Attia, John R" sort="Attia, John R" uniqKey="Attia J" first="John R." last="Attia">John R. Attia</name><affiliation><nlm:aff wicri:cut=" and" id="af49"><addr-line>Public Health Stream</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af51"><addr-line>School of Medicine and Public Health</addr-line><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Yanek, Lisa R" sort="Yanek, Lisa R" uniqKey="Yanek L" first="Lisa R." last="Yanek">Lisa R. Yanek</name><affiliation><nlm:aff id="af53"><addr-line>Department of Medicine</addr-line>,<institution>Johns Hopkins University School of Medicine</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ahluwalia, Tarunveer S" sort="Ahluwalia, Tarunveer S" uniqKey="Ahluwalia T" first="Tarunveer S." last="Ahluwalia">Tarunveer S. Ahluwalia</name><affiliation><nlm:aff id="af54"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line><country>and</country></nlm:aff></affiliation><affiliation><nlm:aff id="af55"><addr-line>Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af56"><addr-line>The Danish Pediatric Asthma Center</addr-line>,<institution>Gentofte Hospital, The Capital Region</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation><nlm:aff id="af57"><addr-line>Institute of Behavioural Sciences</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af60"><institution>Folkhälsan Research Centre</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation><nlm:aff id="af61"><addr-line>Institute of Opthalmology</addr-line>,<institution>UCL</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af62"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>Kings College London</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="af63"><addr-line>Translational Gerontology Branch</addr-line>,<institution>National Institute on Aging</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Bielak, Lawrence F" sort="Bielak, Lawrence F" uniqKey="Bielak L" first="Lawrence F." last="Bielak">Lawrence F. Bielak</name><affiliation><nlm:aff id="af64"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><affiliation><nlm:aff id="af13"><addr-line>Centre for Population Health Sciences</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation><affiliation><nlm:aff id="af14"><addr-line>Centre for Global Health Research</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation></author><author><name sortKey="Rocanin Arjo, Ares" sort="Rocanin Arjo, Ares" uniqKey="Rocanin Arjo A" first="Ares" last="Rocanin-Arjo">Ares Rocanin-Arjo</name><affiliation><nlm:aff id="af65"><institution>Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af66"><institution>Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af67"><institution>Institute for Cardiometabolism and Nutrition (ICAN)</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:aff id="af68"><addr-line>Department of Public Health, Faculty of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation><nlm:aff id="af10"><addr-line>MRC Human Genetics Unit</addr-line>,<institution>Institute of Genetics and Molecular Medicine</institution>,</nlm:aff></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M." last="Rose">Lynda M. Rose</name><affiliation><nlm:aff id="af4"><addr-line>Division of Preventive Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Oldmeadow, Christopher" sort="Oldmeadow, Christopher" uniqKey="Oldmeadow C" first="Christopher" last="Oldmeadow">Christopher Oldmeadow</name><affiliation><nlm:aff wicri:cut=" and" id="af49"><addr-line>Public Health Stream</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af51"><addr-line>School of Medicine and Public Health</addr-line><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Riess, Helene" sort="Riess, Helene" uniqKey="Riess H" first="Helene" last="Riess">Helene Riess</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Institute of Epidemiology II</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mazur, Johanna" sort="Mazur, Johanna" uniqKey="Mazur J" first="Johanna" last="Mazur">Johanna Mazur</name><affiliation><nlm:aff wicri:cut=" and" id="af26"><addr-line>Institute of Medical Biostatistics, Epidemiology and Informatics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name><affiliation><nlm:aff id="af19"><addr-line>Division of Biostatistics</addr-line>,<institution>University of Minnesota</institution>,<addr-line>Minneapolis, MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:aff id="af71"><addr-line>Cardiovascular Medicine Department/Radcliffe Department of Medicine</addr-line>,<institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation><nlm:aff id="af9"><addr-line>Framingham Heart Study, Population Sciences Branch</addr-line>,<institution>Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health</institution>,<addr-line>Framingham, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af72"><addr-line>Department of Biostatistics</addr-line>,<institution>Boston University School of Public Health</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ghanbari, Mohsen" sort="Ghanbari, Mohsen" uniqKey="Ghanbari M" first="Mohsen" last="Ghanbari">Mohsen Ghanbari</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af73"><addr-line>Department of Genetics</addr-line>,<institution>School of Medicine, Mashhad University of Medical Sciences</institution>,<addr-line>Mashhad</addr-line>,<country>Iran</country>,</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="af28"><addr-line>Department of Biological Psychology, Netherlands Twin Register</addr-line>,<institution>VU University</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name><affiliation><nlm:aff id="af74"><addr-line>Institute of Cardiovascular and Medical Sciences</addr-line><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Fiorillo, Edoardo" sort="Fiorillo, Edoardo" uniqKey="Fiorillo E" first="Edoardo" last="Fiorillo">Edoardo Fiorillo</name><affiliation><nlm:aff id="af17"><institution>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche</institution>,<addr-line>Monserrato, Cagliari</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J. M." last="De Craen">Anton J. M. De Craen</name><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Department of Gerontology and Geriatrics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Grotevendt, Anne" sort="Grotevendt, Anne" uniqKey="Grotevendt A" first="Anne" last="Grotevendt">Anne Grotevendt</name><affiliation><nlm:aff id="af21"><addr-line>Institute of Clinical Chemistry and Laboratory Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation><nlm:aff id="af38"><addr-line>MRC Epidemiology Unit</addr-line>,<institution>School of Clinical Medicine</institution> and,</nlm:aff></affiliation></author><author><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D." last="Taylor">Kent D. Taylor</name><affiliation><nlm:aff wicri:cut=" and" id="af45"><addr-line>Institute for Translational Genomics and Population Sciences</addr-line></nlm:aff></affiliation></author><author><name sortKey="Delgado, Graciela E" sort="Delgado, Graciela E" uniqKey="Delgado G" first="Graciela E." last="Delgado">Graciela E. Delgado</name><affiliation><nlm:aff id="af44"><addr-line>Vth Department of Medicine, Medical Faculty Mannheim</addr-line>,<institution>Heidelberg University</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Yao, Jie" sort="Yao, Jie" uniqKey="Yao J" first="Jie" last="Yao">Jie Yao</name><affiliation><nlm:aff wicri:cut=" and" id="af45"><addr-line>Institute for Translational Genomics and Population Sciences</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kifley, Annette" sort="Kifley, Annette" uniqKey="Kifley A" first="Annette" last="Kifley">Annette Kifley</name><affiliation><nlm:aff id="af47"><addr-line>Department of Ophthalmology</addr-line>,<institution>Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation><nlm:aff id="af76"><institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Qayyum, Rehan" sort="Qayyum, Rehan" uniqKey="Qayyum R" first="Rehan" last="Qayyum">Rehan Qayyum</name><affiliation><nlm:aff id="af53"><addr-line>Department of Medicine</addr-line>,<institution>Johns Hopkins University School of Medicine</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation><nlm:aff id="af11"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af77"><addr-line>Department of Psychiatry</addr-line>,<institution>Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital</institution>,<addr-line>Dublin</addr-line>,<country>Ireland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af78"><institution>University College Dublin, UCD Conway Institute, Centre for Proteome Research, UCD</institution>,<addr-line>Belfield, Dublin</addr-line>,<country>Ireland</country>,</nlm:aff></affiliation></author><author><name sortKey="Berentzen, Tina L" sort="Berentzen, Tina L" uniqKey="Berentzen T" first="Tina L." last="Berentzen">Tina L. Berentzen</name><affiliation><nlm:aff id="af79"><addr-line>Institute of Preventive Medicine</addr-line>,<institution>Bispebjerg and Frederiksberg Hospital, The Capital Region</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation><nlm:aff id="af57"><addr-line>Institute of Behavioural Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="af62"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>Kings College London</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="af80"><addr-line>Geriatric Unit</addr-line>,<institution>Azienda Sanitaria Firenze (ASF)</institution>,<addr-line>Florence</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Peyser, Patricia A" sort="Peyser, Patricia A" uniqKey="Peyser P" first="Patricia A." last="Peyser">Patricia A. Peyser</name><affiliation><nlm:aff id="af64"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah" sort="Wild, Sarah" uniqKey="Wild S" first="Sarah" last="Wild">Sarah Wild</name><affiliation><nlm:aff id="af13"><addr-line>Centre for Population Health Sciences</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation></author><author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Trégouët">David-Alexandre Trégouët</name><affiliation><nlm:aff id="af65"><institution>Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af66"><institution>Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af67"><institution>Institute for Cardiometabolism and Nutrition (ICAN)</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="af10"><addr-line>MRC Human Genetics Unit</addr-line>,<institution>Institute of Genetics and Molecular Medicine</institution>,</nlm:aff></affiliation></author><author><name sortKey="Marten, Jonathan" sort="Marten, Jonathan" uniqKey="Marten J" first="Jonathan" last="Marten">Jonathan Marten</name><affiliation><nlm:aff id="af10"><addr-line>MRC Human Genetics Unit</addr-line>,<institution>Institute of Genetics and Molecular Medicine</institution>,</nlm:aff></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation><nlm:aff id="af69"><addr-line>Department of Biology, School of Medicine</addr-line><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C." last="Morrison">Alanna C. Morrison</name><affiliation><nlm:aff id="af81"><addr-line>Human Genetics Center</addr-line>,<institution>University of Texas Health Science Center at Houston</institution>,<addr-line>Houston, TX</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af7"><addr-line>Science for Life Laboratory</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Tofler, Geoffrey" sort="Tofler, Geoffrey" uniqKey="Tofler G" first="Geoffrey" last="Tofler">Geoffrey Tofler</name><affiliation><nlm:aff id="af82"><addr-line>Royal North Shore Hospital</addr-line>,<institution>Sydney University</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="De Maat, Moniek P M" sort="De Maat, Moniek P M" uniqKey="De Maat M" first="Moniek P. M." last="De Maat">Moniek P. M. De Maat</name><affiliation><nlm:aff id="af2"><addr-line>Department of Hematology</addr-line> and,</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation><nlm:aff id="af28"><addr-line>Department of Biological Psychology, Netherlands Twin Register</addr-line>,<institution>VU University</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af83"><addr-line>EMGO+ institute</addr-line>,<institution>VU University & VU Medical Center</institution>,<addr-line>Amsterdam</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lowe, Gordon D" sort="Lowe, Gordon D" uniqKey="Lowe G" first="Gordon D." last="Lowe">Gordon D. Lowe</name><affiliation><nlm:aff id="af74"><addr-line>Institute of Cardiovascular and Medical Sciences</addr-line><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Zoledziewska, Magdalena" sort="Zoledziewska, Magdalena" uniqKey="Zoledziewska M" first="Magdalena" last="Zoledziewska">Magdalena Zoledziewska</name><affiliation><nlm:aff id="af17"><institution>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche</institution>,<addr-line>Monserrato, Cagliari</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation><nlm:aff id="af84"><addr-line>Faculty of Medicine</addr-line>,<institution>BHF Glasgow Cardiovascular Research Centre</institution>,<addr-line>Glasgow</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Binder, Harald" sort="Binder, Harald" uniqKey="Binder H" first="Harald" last="Binder">Harald Binder</name><affiliation><nlm:aff wicri:cut=" and" id="af26"><addr-line>Institute of Medical Biostatistics, Epidemiology and Informatics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:aff wicri:cut=" and" id="af22"><addr-line>Interfaculty Institute for Genetics and Functional Genomics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Institute of Epidemiology II</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af34"><addr-line>Research Unit of Molecular Epidemiology</addr-line>,<institution>Helmholtz ZentrumMünchen – German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="af39"><addr-line>Clinical Gerontology Unit</addr-line>,<institution>School of Clinical Medicine, University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:aff id="af41"><addr-line>Department of Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name><affiliation><nlm:aff id="af85"><addr-line>Department of Human Genetics</addr-line>,<institution>Wellcome Trust Sanger Institute</institution>,<addr-line>Hinxton, Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Jenny, Nancy S" sort="Jenny, Nancy S" uniqKey="Jenny N" first="Nancy S." last="Jenny">Nancy S. Jenny</name><affiliation><nlm:aff id="af86"><addr-line>Department of Pathology and Laboratory Medicine</addr-line><country>and</country>,</nlm:aff></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation><nlm:aff id="af88"><addr-line>Public Health Stream</addr-line>,<institution>Hunter Medical Research Institute, School of Medicine and Public Health</institution><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Qi, Lihong" sort="Qi, Lihong" uniqKey="Qi L" first="Lihong" last="Qi">Lihong Qi</name><affiliation><nlm:aff id="af90"><addr-line>Division of Biostatistics, Department of Public Health Sciences</addr-line>,<institution>UC Davis</institution>,<addr-line>Davis, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Mcevoy, Mark G" sort="Mcevoy, Mark G" uniqKey="Mcevoy M" first="Mark G." last="Mcevoy">Mark G. Mcevoy</name><affiliation><nlm:aff id="af89"><addr-line>School of Medicine and Public Health</addr-line>,<institution>University of Newcastle</institution>,<addr-line>Newcastle</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Becker, Diane M" sort="Becker, Diane M" uniqKey="Becker D" first="Diane M." last="Becker">Diane M. Becker</name><affiliation><nlm:aff id="af53"><addr-line>Department of Medicine</addr-line>,<institution>Johns Hopkins University School of Medicine</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation><nlm:aff id="af11"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Alzheimer Scotland Dementia Research Centre</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sarin, Antti Pekka" sort="Sarin, Antti Pekka" uniqKey="Sarin A" first="Antti-Pekka" last="Sarin">Antti-Pekka Sarin</name><affiliation><nlm:aff wicri:cut=" and" id="af58"><addr-line>Institute for Molecular Medicine Finland (FIMM)</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af91"><addr-line>Public Health Genomics Unit</addr-line>,<institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><affiliation><nlm:aff id="af62"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>Kings College London</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena G." last="Hernandez">Dena G. Hernandez</name><affiliation><nlm:aff id="af92"><addr-line>Laboratory of Neurogenetics</addr-line>,<institution>National Institute on Aging</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Jhun, Min A" sort="Jhun, Min A" uniqKey="Jhun M" first="Min A." last="Jhun">Min A. Jhun</name><affiliation><nlm:aff id="af64"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="af14"><addr-line>Centre for Global Health Research</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Internal Medicine</addr-line>,<institution>Erasmus MC</institution>,<addr-line>Wytemaweg 80</addr-line>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="af93"><addr-line>School of Social and Community Medicine</addr-line>,<institution>University of Bristol</institution>,<addr-line>Bristol</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P. Eline" last="Slagboom">P. Eline Slagboom</name><affiliation><nlm:aff id="af31"><addr-line>Department of Molecular Epidemiology</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation><nlm:aff id="af94"><addr-line>Department of General and Interventional Cardiology</addr-line>,<institution>University Heart Centre, University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af95"><institution>German Center for Cardiovascular Research (DZHK), Partner Site Hamburg</institution>,<addr-line>Lübeck, Kiel, Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation><nlm:aff id="af37"><addr-line>German Centre for Cardiovascular Research (DZHK)</addr-line>,<institution>Partner Site Munich Heart Alliance</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af96"><addr-line>Department of Internal Medicine II – Cardiology</addr-line>,<institution>University of Ulm Medical Centre</institution>,<addr-line>Ulm</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af97"><addr-line>Deutsches Herzzentrum München</addr-line>,<institution>Technische Universität München</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff wicri:cut=" and" id="af42"><addr-line>Department of Medicine, Epidemiology, and Health Services</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af98"><institution>Group Health Research Institute, Group Health Cooperative</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Haritunians, Talin" sort="Haritunians, Talin" uniqKey="Haritunians T" first="Talin" last="Haritunians">Talin Haritunians</name><affiliation><nlm:aff id="af99"><addr-line>Inflammatory Bowel & Immunobiology Research Institute</addr-line>,<institution>Cedars-Sinai Medical Center</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Liu, Jingmin" sort="Liu, Jingmin" uniqKey="Liu J" first="Jingmin" last="Liu">Jingmin Liu</name><affiliation><nlm:aff id="af76"><institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:aff wicri:cut=" and" id="af58"><addr-line>Institute for Molecular Medicine Finland (FIMM)</addr-line></nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Internal Medicine</addr-line>,<institution>Erasmus MC</institution>,<addr-line>Wytemaweg 80</addr-line>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J." last="Stott">David J. Stott</name><affiliation><nlm:aff id="af75"><addr-line>Institute of Cardiovascular and Medical Sciences</addr-line>,<institution>Faculty of Medicine, University of Glasgow</institution>,<addr-line>Glasgow</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="af14"><addr-line>Centre for Global Health Research</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation><affiliation><nlm:aff id="af70"><addr-line>Department of Public Health</addr-line>,<addr-line>Faculty of Medicine</addr-line>,<institution>Centre for Global Health, University of Split</institution>,<addr-line>Split</addr-line>,<country>Croatia</country>,</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="af14"><addr-line>Centre for Global Health Research</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation></author><author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name><affiliation><nlm:aff id="af100"><addr-line>Laboratory of Haematology</addr-line>,<institution>La Timone Hospital</institution>,<addr-line>Marseille F-13385</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af101"><institution>INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis</institution>,<addr-line>Marseille F-13385</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af102"><institution>Aix-Marseille University, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis</institution>,<addr-line>Marseille F-13385</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="af10"><addr-line>MRC Human Genetics Unit</addr-line>,<institution>Institute of Genetics and Molecular Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff id="af14"><addr-line>Centre for Global Health Research</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</nlm:aff></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name><affiliation><nlm:aff id="af64"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="af63"><addr-line>Translational Gerontology Branch</addr-line>,<institution>National Institute on Aging</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="af62"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>Kings College London</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="af59"><addr-line>Department of General Practice and Primary Health Care</addr-line>,<institution>University of Helsinki</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af60"><institution>Folkhälsan Research Centre</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af103"><institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af104"><addr-line>Unit of General Practice</addr-line>,<institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation><nlm:aff id="af54"><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line><country>and</country></nlm:aff></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation><nlm:aff id="af11"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af16"><addr-line>Department of Psychology</addr-line>,<institution>University of Edinburgh</institution>,<addr-line>Edinburgh</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Becker, Lewis C" sort="Becker, Lewis C" uniqKey="Becker L" first="Lewis C." last="Becker">Lewis C. Becker</name><affiliation><nlm:aff id="af53"><addr-line>Department of Medicine</addr-line>,<institution>Johns Hopkins University School of Medicine</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation><nlm:aff id="af50"><addr-line>Information based Medicine Program</addr-line>,<institution>Hunter Medical Research Institute</institution>,<addr-line>New Lambton Heights</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af52"><addr-line>School of Biomedical Sciences and Pharmacy</addr-line>,<institution>University of Newcastle</institution>,<addr-line>New Lambton Heights</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation><nlm:aff id="af47"><addr-line>Department of Ophthalmology</addr-line>,<institution>Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation><nlm:aff id="af44"><addr-line>Vth Department of Medicine, Medical Faculty Mannheim</addr-line>,<institution>Heidelberg University</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af105"><addr-line>Synlab Academy</addr-line>,<institution>Synlab Services LLC</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af106"><addr-line>Clinical Institute of Medical</addr-line>,<addr-line>Chemical Laboratory Diagnostics</addr-line>,<institution>Medical University of Graz</institution>,<addr-line>Graz</addr-line>,<country>Austria</country>,</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J." last="Wareham">Nick J. Wareham</name><affiliation><nlm:aff id="af38"><addr-line>MRC Epidemiology Unit</addr-line>,<institution>School of Clinical Medicine</institution> and,</nlm:aff></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Institute of Epidemiology II</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af36"><addr-line>DZHK (German Centre for Cardiovascular Research)</addr-line></nlm:aff></affiliation></author><author><name sortKey="Greinacher, Andreas" sort="Greinacher, Andreas" uniqKey="Greinacher A" first="Andreas" last="Greinacher">Andreas Greinacher</name><affiliation><nlm:aff id="af23"><addr-line>Institute for Immunology and Transfusion Medicine</addr-line>,<institution>University Medicine Greifswald</institution>,<addr-line>Greifswald</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S." last="Wild">Philipp S. Wild</name><affiliation><nlm:aff id="af25"><addr-line>Center for Thrombosis and Hemostasis (CTH)</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af27"><addr-line>Preventive Cardiology and Preventive Medicine, Department of Medicine 2</addr-line>,<institution>University Medical Center of the Johannes Gutenberg University Mainz</institution>,<addr-line>Mainz</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af107"><addr-line>German Center for Cardiovascular Research (DZHK)</addr-line>,<institution>Partner Site RheinMain</institution>,<addr-line>Mainz</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><affiliation><nlm:aff id="af29"><addr-line>Department of Cardiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af108"><institution>Durrer Center for Cardiogenetic Research</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af109"><institution>Interuniversity Cardiology Institute of The Netherlands</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="af28"><addr-line>Department of Biological Psychology, Netherlands Twin Register</addr-line>,<institution>VU University</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="af10"><addr-line>MRC Human Genetics Unit</addr-line>,<institution>Institute of Genetics and Molecular Medicine</institution>,</nlm:aff></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation><nlm:aff id="af17"><institution>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche</institution>,<addr-line>Monserrato, Cagliari</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Tracy, Russell" sort="Tracy, Russell" uniqKey="Tracy R" first="Russell" last="Tracy">Russell Tracy</name><affiliation><nlm:aff id="af87"><addr-line>Department of Pathology and Laboratory Medicine</addr-line>,<institution>Center for Clinical and Translational Sciences, University of Vermont College of Medicine</institution>,<addr-line>Colchester, VT</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="af71"><addr-line>Cardiovascular Medicine Department/Radcliffe Department of Medicine</addr-line>,<institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P." last="Reiner">Alex P. Reiner</name><affiliation><nlm:aff id="af76"><institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af110"><institution>University of Washington</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><affiliation><nlm:aff wicri:cut=" and" id="af18"><addr-line>Division of Epidemiology and Community Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="af4"><addr-line>Division of Preventive Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af5"><institution>Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name><affiliation><nlm:aff id="af9"><addr-line>Framingham Heart Study, Population Sciences Branch</addr-line>,<institution>Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health</institution>,<addr-line>Framingham, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af111"><institution>National Heart, Lung and Blood Institute, Division of Intramural Research</institution>,</nlm:aff></affiliation><affiliation><nlm:aff id="af112"><addr-line>Cardiology Division</addr-line>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name><affiliation><nlm:aff id="af43"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Washington</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af75"><addr-line>Institute of Cardiovascular and Medical Sciences</addr-line>,<institution>Faculty of Medicine, University of Glasgow</institution>,<addr-line>Glasgow</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af113"><addr-line>Department of Veterans Affairs</addr-line>,<institution>Office of Research and Development, Seattle Epidemiologic Research and Information Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="af114"><addr-line>Population Health Research Institute, St George's</addr-line><institution>University of London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>,</nlm:aff></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: <italic>FGB</italic> and <italic>IRF1</italic>. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id><journal-id journal-id-type="iso-abbrev">Hum. Mol. Genet</journal-id><journal-id journal-id-type="publisher-id">hmg</journal-id><journal-id journal-id-type="hwp">hmg</journal-id><journal-title-group><journal-title>Human Molecular Genetics</journal-title></journal-title-group><issn pub-type="ppub">0964-6906</issn><issn pub-type="epub">1460-2083</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26561523</article-id><article-id pub-id-type="pmc">4715256</article-id><article-id pub-id-type="doi">10.1093/hmg/ddv454</article-id><article-id pub-id-type="publisher-id">ddv454</article-id><article-categories><subj-group subj-group-type="heading"><subject>Association Studies Articles</subject></subj-group></article-categories><title-group><article-title>A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>de Vries</surname><given-names>Paul S.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chasman</surname><given-names>Daniel I.</given-names></name><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Sabater-Lleal</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Ming-Huei</given-names></name><xref ref-type="aff" rid="af8">8</xref><xref ref-type="aff" rid="af9">9</xref></contrib><contrib contrib-type="author"><name><surname>Huffman</surname><given-names>Jennifer E.</given-names></name><xref ref-type="aff" rid="af9">9</xref><xref ref-type="aff" rid="af10">10</xref></contrib><contrib contrib-type="author"><name><surname>Steri</surname><given-names>Maristella</given-names></name><xref ref-type="aff" rid="af17">17</xref></contrib><contrib contrib-type="author"><name><surname>Tang</surname><given-names>Weihong</given-names></name><xref ref-type="aff" rid="af18">18</xref></contrib><contrib contrib-type="author"><name><surname>Teumer</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="af20">20</xref></contrib><contrib contrib-type="author"><name><surname>Marioni</surname><given-names>Riccardo E.</given-names></name><xref ref-type="aff" rid="af11">11</xref><xref ref-type="aff" rid="af12">12</xref><xref ref-type="aff" rid="af24">24</xref></contrib><contrib contrib-type="author"><name><surname>Grossmann</surname><given-names>Vera</given-names></name><xref ref-type="aff" rid="af25">25</xref></contrib><contrib contrib-type="author"><name><surname>Hottenga</surname><given-names>Jouke J.</given-names></name><xref ref-type="aff" rid="af28">28</xref></contrib><contrib contrib-type="author"><name><surname>Trompet</surname><given-names>Stella</given-names></name><xref ref-type="aff" rid="af29">29</xref><xref ref-type="aff" rid="af30">30</xref></contrib><contrib contrib-type="author"><name><surname>Müller-Nurasyid</surname><given-names>Martina</given-names></name><xref ref-type="aff" rid="af32">32</xref><xref ref-type="aff" rid="af35">35</xref><xref ref-type="aff" rid="af36">36</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Jing Hua</given-names></name><xref ref-type="aff" rid="af38">38</xref></contrib><contrib contrib-type="author"><name><surname>Brody</surname><given-names>Jennifer A.</given-names></name><xref ref-type="aff" rid="af40">40</xref></contrib><contrib contrib-type="author"><name><surname>Kleber</surname><given-names>Marcus E.</given-names></name><xref ref-type="aff" rid="af44">44</xref></contrib><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Xiuqing</given-names></name><xref ref-type="aff" rid="af45">45</xref><xref ref-type="aff" rid="af46">46</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Jie Jin</given-names></name><xref ref-type="aff" rid="af47">47</xref></contrib><contrib contrib-type="author"><name><surname>Auer</surname><given-names>Paul L.</given-names></name><xref ref-type="aff" rid="af48">48</xref></contrib><contrib contrib-type="author"><name><surname>Attia</surname><given-names>John R.</given-names></name><xref ref-type="aff" rid="af49">49</xref><xref ref-type="aff" rid="af51">51</xref></contrib><contrib contrib-type="author"><name><surname>Yanek</surname><given-names>Lisa R.</given-names></name><xref ref-type="aff" rid="af53">53</xref></contrib><contrib contrib-type="author"><name><surname>Ahluwalia</surname><given-names>Tarunveer S.</given-names></name><xref ref-type="aff" rid="af54">54</xref><xref ref-type="aff" rid="af55">55</xref><xref ref-type="aff" rid="af56">56</xref></contrib><contrib contrib-type="author"><name><surname>Lahti</surname><given-names>Jari</given-names></name><xref ref-type="aff" rid="af57">57</xref><xref ref-type="aff" rid="af60">60</xref></contrib><contrib contrib-type="author"><name><surname>Venturini</surname><given-names>Cristina</given-names></name><xref ref-type="aff" rid="af61">61</xref><xref ref-type="aff" rid="af62">62</xref></contrib><contrib contrib-type="author"><name><surname>Tanaka</surname><given-names>Toshiko</given-names></name><xref ref-type="aff" rid="af63">63</xref></contrib><contrib contrib-type="author"><name><surname>Bielak</surname><given-names>Lawrence F.</given-names></name><xref ref-type="aff" rid="af64">64</xref></contrib><contrib contrib-type="author"><name><surname>Joshi</surname><given-names>Peter K.</given-names></name><xref ref-type="aff" rid="af13">13</xref><xref ref-type="aff" rid="af14">14</xref></contrib><contrib contrib-type="author"><name><surname>Rocanin-Arjo</surname><given-names>Ares</given-names></name><xref ref-type="aff" rid="af65">65</xref><xref ref-type="aff" rid="af66">66</xref><xref ref-type="aff" rid="af67">67</xref></contrib><contrib contrib-type="author"><name><surname>Kolcic</surname><given-names>Ivana</given-names></name><xref ref-type="aff" rid="af68">68</xref></contrib><contrib contrib-type="author"><name><surname>Navarro</surname><given-names>Pau</given-names></name><xref ref-type="aff" rid="af10">10</xref></contrib><contrib contrib-type="author"><name><surname>Rose</surname><given-names>Lynda M.</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Oldmeadow</surname><given-names>Christopher</given-names></name><xref ref-type="aff" rid="af49">49</xref><xref ref-type="aff" rid="af51">51</xref></contrib><contrib contrib-type="author"><name><surname>Riess</surname><given-names>Helene</given-names></name><xref ref-type="aff" rid="af33">33</xref></contrib><contrib contrib-type="author"><name><surname>Mazur</surname><given-names>Johanna</given-names></name><xref ref-type="aff" rid="af26">26</xref></contrib><contrib contrib-type="author"><name><surname>Basu</surname><given-names>Saonli</given-names></name><xref ref-type="aff" rid="af19">19</xref></contrib><contrib contrib-type="author"><name><surname>Goel</surname><given-names>Anuj</given-names></name><xref ref-type="aff" rid="af71">71</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Qiong</given-names></name><xref ref-type="aff" rid="af9">9</xref><xref ref-type="aff" rid="af72">72</xref></contrib><contrib contrib-type="author"><name><surname>Ghanbari</surname><given-names>Mohsen</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af73">73</xref></contrib><contrib contrib-type="author"><name><surname>Willemsen</surname><given-names>Gonneke</given-names></name><xref ref-type="aff" rid="af28">28</xref></contrib><contrib contrib-type="author"><name><surname>Rumley</surname><given-names>Ann</given-names></name><xref ref-type="aff" rid="af74">74</xref></contrib><contrib contrib-type="author"><name><surname>Fiorillo</surname><given-names>Edoardo</given-names></name><xref ref-type="aff" rid="af17">17</xref></contrib><contrib contrib-type="author"><name><surname>de Craen</surname><given-names>Anton J. M.</given-names></name><xref ref-type="aff" rid="af30">30</xref></contrib><contrib contrib-type="author"><name><surname>Grotevendt</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="af21">21</xref></contrib><contrib contrib-type="author"><name><surname>Scott</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="af38">38</xref></contrib><contrib contrib-type="author"><name><surname>Taylor</surname><given-names>Kent D.</given-names></name><xref ref-type="aff" rid="af45">45</xref></contrib><contrib contrib-type="author"><name><surname>Delgado</surname><given-names>Graciela E.</given-names></name><xref ref-type="aff" rid="af44">44</xref></contrib><contrib contrib-type="author"><name><surname>Yao</surname><given-names>Jie</given-names></name><xref ref-type="aff" rid="af45">45</xref></contrib><contrib contrib-type="author"><name><surname>Kifley</surname><given-names>Annette</given-names></name><xref ref-type="aff" rid="af47">47</xref></contrib><contrib contrib-type="author"><name><surname>Kooperberg</surname><given-names>Charles</given-names></name><xref ref-type="aff" rid="af76">76</xref></contrib><contrib contrib-type="author"><name><surname>Qayyum</surname><given-names>Rehan</given-names></name><xref ref-type="aff" rid="af53">53</xref></contrib><contrib contrib-type="author"><name><surname>Lopez</surname><given-names>Lorna M.</given-names></name><xref ref-type="aff" rid="af11">11</xref><xref ref-type="aff" rid="af77">77</xref><xref ref-type="aff" rid="af78">78</xref></contrib><contrib contrib-type="author"><name><surname>Berentzen</surname><given-names>Tina L.</given-names></name><xref ref-type="aff" rid="af79">79</xref></contrib><contrib contrib-type="author"><name><surname>Räikkönen</surname><given-names>Katri</given-names></name><xref ref-type="aff" rid="af57">57</xref></contrib><contrib contrib-type="author"><name><surname>Mangino</surname><given-names>Massimo</given-names></name><xref ref-type="aff" rid="af62">62</xref></contrib><contrib contrib-type="author"><name><surname>Bandinelli</surname><given-names>Stefania</given-names></name><xref ref-type="aff" rid="af80">80</xref></contrib><contrib contrib-type="author"><name><surname>Peyser</surname><given-names>Patricia A.</given-names></name><xref ref-type="aff" rid="af64">64</xref></contrib><contrib contrib-type="author"><name><surname>Wild</surname><given-names>Sarah</given-names></name><xref ref-type="aff" rid="af13">13</xref></contrib><contrib contrib-type="author"><name><surname>Trégouët</surname><given-names>David-Alexandre</given-names></name><xref ref-type="aff" rid="af65">65</xref><xref ref-type="aff" rid="af66">66</xref><xref ref-type="aff" rid="af67">67</xref></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>Alan F.</given-names></name><xref ref-type="aff" rid="af10">10</xref></contrib><contrib contrib-type="author"><name><surname>Marten</surname><given-names>Jonathan</given-names></name><xref ref-type="aff" rid="af10">10</xref></contrib><contrib contrib-type="author"><name><surname>Zemunik</surname><given-names>Tatijana</given-names></name><xref ref-type="aff" rid="af69">69</xref></contrib><contrib contrib-type="author"><name><surname>Morrison</surname><given-names>Alanna C.</given-names></name><xref ref-type="aff" rid="af81">81</xref></contrib><contrib contrib-type="author"><name><surname>Sennblad</surname><given-names>Bengt</given-names></name><xref ref-type="aff" rid="af6">6</xref><xref ref-type="aff" rid="af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Tofler</surname><given-names>Geoffrey</given-names></name><xref ref-type="aff" rid="af82">82</xref></contrib><contrib contrib-type="author"><name><surname>de Maat</surname><given-names>Moniek P. M.</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>de Geus</surname><given-names>Eco J. C.</given-names></name><xref ref-type="aff" rid="af28">28</xref><xref ref-type="aff" rid="af83">83</xref></contrib><contrib contrib-type="author"><name><surname>Lowe</surname><given-names>Gordon D.</given-names></name><xref ref-type="aff" rid="af74">74</xref></contrib><contrib contrib-type="author"><name><surname>Zoledziewska</surname><given-names>Magdalena</given-names></name><xref ref-type="aff" rid="af17">17</xref></contrib><contrib contrib-type="author"><name><surname>Sattar</surname><given-names>Naveed</given-names></name><xref ref-type="aff" rid="af84">84</xref></contrib><contrib contrib-type="author"><name><surname>Binder</surname><given-names>Harald</given-names></name><xref ref-type="aff" rid="af26">26</xref></contrib><contrib contrib-type="author"><name><surname>Völker</surname><given-names>Uwe</given-names></name><xref ref-type="aff" rid="af22">22</xref></contrib><contrib contrib-type="author"><name><surname>Waldenberger</surname><given-names>Melanie</given-names></name><xref ref-type="aff" rid="af33">33</xref><xref ref-type="aff" rid="af34">34</xref></contrib><contrib contrib-type="author"><name><surname>Khaw</surname><given-names>Kay-Tee</given-names></name><xref ref-type="aff" rid="af39">39</xref></contrib><contrib contrib-type="author"><name><surname>Mcknight</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="af41">41</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Jie</given-names></name><xref ref-type="aff" rid="af85">85</xref></contrib><contrib contrib-type="author"><name><surname>Jenny</surname><given-names>Nancy S.</given-names></name><xref ref-type="aff" rid="af86">86</xref></contrib><contrib contrib-type="author"><name><surname>Holliday</surname><given-names>Elizabeth G.</given-names></name><xref ref-type="aff" rid="af88">88</xref></contrib><contrib contrib-type="author"><name><surname>Qi</surname><given-names>Lihong</given-names></name><xref ref-type="aff" rid="af90">90</xref></contrib><contrib contrib-type="author"><name><surname>Mcevoy</surname><given-names>Mark G.</given-names></name><xref ref-type="aff" rid="af89">89</xref></contrib><contrib contrib-type="author"><name><surname>Becker</surname><given-names>Diane M.</given-names></name><xref ref-type="aff" rid="af53">53</xref></contrib><contrib contrib-type="author"><name><surname>Starr</surname><given-names>John M.</given-names></name><xref ref-type="aff" rid="af11">11</xref><xref ref-type="aff" rid="af15">15</xref></contrib><contrib contrib-type="author"><name><surname>Sarin</surname><given-names>Antti-Pekka</given-names></name><xref ref-type="aff" rid="af58">58</xref><xref ref-type="aff" rid="af91">91</xref></contrib><contrib contrib-type="author"><name><surname>Hysi</surname><given-names>Pirro G.</given-names></name><xref ref-type="aff" rid="af62">62</xref></contrib><contrib contrib-type="author"><name><surname>Hernandez</surname><given-names>Dena G.</given-names></name><xref ref-type="aff" rid="af92">92</xref></contrib><contrib contrib-type="author"><name><surname>Jhun</surname><given-names>Min A.</given-names></name><xref ref-type="aff" rid="af64">64</xref></contrib><contrib contrib-type="author"><name><surname>Campbell</surname><given-names>Harry</given-names></name><xref ref-type="aff" rid="af14">14</xref></contrib><contrib contrib-type="author"><name><surname>Hamsten</surname><given-names>Anders</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Rivadeneira</surname><given-names>Fernando</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Mcardle</surname><given-names>Wendy L.</given-names></name><xref ref-type="aff" rid="af93">93</xref></contrib><contrib contrib-type="author"><name><surname>Slagboom</surname><given-names>P. Eline</given-names></name><xref ref-type="aff" rid="af31">31</xref></contrib><contrib contrib-type="author"><name><surname>Zeller</surname><given-names>Tanja</given-names></name><xref ref-type="aff" rid="af94">94</xref><xref ref-type="aff" rid="af95">95</xref></contrib><contrib contrib-type="author"><name><surname>Koenig</surname><given-names>Wolfgang</given-names></name><xref ref-type="aff" rid="af37">37</xref><xref ref-type="aff" rid="af96">96</xref><xref ref-type="aff" rid="af97">97</xref></contrib><contrib contrib-type="author"><name><surname>Psaty</surname><given-names>Bruce M.</given-names></name><xref ref-type="aff" rid="af42">42</xref><xref ref-type="aff" rid="af98">98</xref></contrib><contrib contrib-type="author"><name><surname>Haritunians</surname><given-names>Talin</given-names></name><xref ref-type="aff" rid="af99">99</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Jingmin</given-names></name><xref ref-type="aff" rid="af76">76</xref></contrib><contrib contrib-type="author"><name><surname>Palotie</surname><given-names>Aarno</given-names></name><xref ref-type="aff" rid="af58">58</xref></contrib><contrib contrib-type="author"><name><surname>Uitterlinden</surname><given-names>André G.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Stott</surname><given-names>David J.</given-names></name><xref ref-type="aff" rid="af75">75</xref></contrib><contrib contrib-type="author"><name><surname>Hofman</surname><given-names>Albert</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Franco</surname><given-names>Oscar H.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Polasek</surname><given-names>Ozren</given-names></name><xref ref-type="aff" rid="af14">14</xref><xref ref-type="aff" rid="af70">70</xref></contrib><contrib contrib-type="author"><name><surname>Rudan</surname><given-names>Igor</given-names></name><xref ref-type="aff" rid="af14">14</xref></contrib><contrib contrib-type="author"><name><surname>Morange</surname><given-names>Pierre-Emmanuel</given-names></name><xref ref-type="aff" rid="af100">100</xref><xref ref-type="aff" rid="af101">101</xref><xref ref-type="aff" rid="af102">102</xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>James F.</given-names></name><xref ref-type="aff" rid="af10">10</xref><xref ref-type="aff" rid="af14">14</xref></contrib><contrib contrib-type="author"><name><surname>Kardia</surname><given-names>Sharon L. R.</given-names></name><xref ref-type="aff" rid="af64">64</xref></contrib><contrib contrib-type="author"><name><surname>Ferrucci</surname><given-names>Luigi</given-names></name><xref ref-type="aff" rid="af63">63</xref></contrib><contrib contrib-type="author"><name><surname>Spector</surname><given-names>Tim D.</given-names></name><xref ref-type="aff" rid="af62">62</xref></contrib><contrib contrib-type="author"><name><surname>Eriksson</surname><given-names>Johan G.</given-names></name><xref ref-type="aff" rid="af59">59</xref><xref ref-type="aff" rid="af60">60</xref><xref ref-type="aff" rid="af103">103</xref><xref ref-type="aff" rid="af104">104</xref></contrib><contrib contrib-type="author"><name><surname>Hansen</surname><given-names>Torben</given-names></name><xref ref-type="aff" rid="af54">54</xref></contrib><contrib contrib-type="author"><name><surname>Deary</surname><given-names>Ian J.</given-names></name><xref ref-type="aff" rid="af11">11</xref><xref ref-type="aff" rid="af16">16</xref></contrib><contrib contrib-type="author"><name><surname>Becker</surname><given-names>Lewis C.</given-names></name><xref ref-type="aff" rid="af53">53</xref></contrib><contrib contrib-type="author"><name><surname>Scott</surname><given-names>Rodney J.</given-names></name><xref ref-type="aff" rid="af50">50</xref><xref ref-type="aff" rid="af52">52</xref></contrib><contrib contrib-type="author"><name><surname>Mitchell</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="af47">47</xref></contrib><contrib contrib-type="author"><name><surname>März</surname><given-names>Winfried</given-names></name><xref ref-type="aff" rid="af44">44</xref><xref ref-type="aff" rid="af105">105</xref><xref ref-type="aff" rid="af106">106</xref></contrib><contrib contrib-type="author"><name><surname>Wareham</surname><given-names>Nick J.</given-names></name><xref ref-type="aff" rid="af38">38</xref></contrib><contrib contrib-type="author"><name><surname>Peters</surname><given-names>Annette</given-names></name><xref ref-type="aff" rid="af33">33</xref><xref ref-type="aff" rid="af36">36</xref></contrib><contrib contrib-type="author"><name><surname>Greinacher</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="af23">23</xref></contrib><contrib contrib-type="author"><name><surname>Wild</surname><given-names>Philipp S.</given-names></name><xref ref-type="aff" rid="af25">25</xref><xref ref-type="aff" rid="af27">27</xref><xref ref-type="aff" rid="af107">107</xref></contrib><contrib contrib-type="author"><name><surname>Jukema</surname><given-names>J. Wouter</given-names></name><xref ref-type="aff" rid="af29">29</xref><xref ref-type="aff" rid="af108">108</xref><xref ref-type="aff" rid="af109">109</xref></contrib><contrib contrib-type="author"><name><surname>Boomsma</surname><given-names>Dorret I.</given-names></name><xref ref-type="aff" rid="af28">28</xref></contrib><contrib contrib-type="author"><name><surname>Hayward</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="af10">10</xref></contrib><contrib contrib-type="author"><name><surname>Cucca</surname><given-names>Francesco</given-names></name><xref ref-type="aff" rid="af17">17</xref></contrib><contrib contrib-type="author"><name><surname>Tracy</surname><given-names>Russell</given-names></name><xref ref-type="aff" rid="af87">87</xref></contrib><contrib contrib-type="author"><name><surname>Watkins</surname><given-names>Hugh</given-names></name><xref ref-type="aff" rid="af71">71</xref></contrib><contrib contrib-type="author"><name><surname>Reiner</surname><given-names>Alex P.</given-names></name><xref ref-type="aff" rid="af76">76</xref><xref ref-type="aff" rid="af110">110</xref></contrib><contrib contrib-type="author"><name><surname>Folsom</surname><given-names>Aaron R.</given-names></name><xref ref-type="aff" rid="af18">18</xref></contrib><contrib contrib-type="author"><name><surname>Ridker</surname><given-names>Paul M.</given-names></name><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>O'Donnell</surname><given-names>Christopher J.</given-names></name><xref ref-type="aff" rid="af9">9</xref><xref ref-type="aff" rid="af111">111</xref><xref ref-type="aff" rid="af112">112</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Nicholas L.</given-names></name><xref ref-type="aff" rid="af43">43</xref><xref ref-type="aff" rid="af75">75</xref><xref ref-type="aff" rid="af113">113</xref></contrib><contrib contrib-type="author"><name><surname>Strachan</surname><given-names>David P.</given-names></name><xref ref-type="aff" rid="af114">114</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Dehghan</surname><given-names>Abbas</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="author-notes" rid="AN1">†</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><aff id="af1"><label>1</label><addr-line>Department of Epidemiology</addr-line>,</aff><aff id="af2"><label>2</label><addr-line>Department of Hematology</addr-line> and,</aff><aff id="af3"><label>3</label><addr-line>Department of Internal Medicine</addr-line>,<institution>Erasmus MC</institution>,<addr-line>Wytemaweg 80</addr-line>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af4"><label>4</label><addr-line>Division of Preventive Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af5"><label>5</label><institution>Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af6"><label>6</label><addr-line>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit</addr-line> and</aff><aff id="af7"><label>7</label><addr-line>Science for Life Laboratory</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</aff><aff id="af8"><label>8</label><addr-line>Department of Neurology</addr-line>,<institution>Boston University School of Medicine</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af9"><label>9</label><addr-line>Framingham Heart Study, Population Sciences Branch</addr-line>,<institution>Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health</institution>,<addr-line>Framingham, MA</addr-line>,<country>USA</country>,</aff><aff id="af10"><label>10</label><addr-line>MRC Human Genetics Unit</addr-line>,<institution>Institute of Genetics and Molecular Medicine</institution>,</aff><aff id="af11"><label>11</label><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology</addr-line>,</aff><aff id="af12"><label>12</label><addr-line>Centre for Genomic and Experimental Medicine</addr-line>,</aff><aff id="af13"><label>13</label><addr-line>Centre for Population Health Sciences</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</aff><aff id="af14"><label>14</label><addr-line>Centre for Global Health Research</addr-line>,<institution>Usher Institute of Population Health Sciences and Informatics</institution>,</aff><aff id="af15"><label>15</label><addr-line>Alzheimer Scotland Dementia Research Centre</addr-line> and</aff><aff id="af16"><label>16</label><addr-line>Department of Psychology</addr-line>,<institution>University of Edinburgh</institution>,<addr-line>Edinburgh</addr-line>,<country>UK</country>,</aff><aff id="af17"><label>17</label><institution>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche</institution>,<addr-line>Monserrato, Cagliari</addr-line>,<country>Italy</country>,</aff><aff id="af18"><label>18</label><addr-line>Division of Epidemiology and Community Health</addr-line> and</aff><aff id="af19"><label>19</label><addr-line>Division of Biostatistics</addr-line>,<institution>University of Minnesota</institution>,<addr-line>Minneapolis, MN</addr-line>,<country>USA</country>,</aff><aff id="af20"><label>20</label><addr-line>Institute for Community Medicine</addr-line>,</aff><aff id="af21"><label>21</label><addr-line>Institute of Clinical Chemistry and Laboratory Medicine</addr-line>,</aff><aff id="af22"><label>22</label><addr-line>Interfaculty Institute for Genetics and Functional Genomics</addr-line> and</aff><aff id="af23"><label>23</label><addr-line>Institute for Immunology and Transfusion Medicine</addr-line>,<institution>University Medicine Greifswald</institution>,<addr-line>Greifswald</addr-line>,<country>Germany</country>,</aff><aff id="af24"><label>24</label><addr-line>Queensland Brain Institute</addr-line>,<institution>University of Queensland</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</aff><aff id="af25"><label>25</label><addr-line>Center for Thrombosis and Hemostasis (CTH)</addr-line>,</aff><aff id="af26"><label>26</label><addr-line>Institute of Medical Biostatistics, Epidemiology and Informatics</addr-line> and</aff><aff id="af27"><label>27</label><addr-line>Preventive Cardiology and Preventive Medicine, Department of Medicine 2</addr-line>,<institution>University Medical Center of the Johannes Gutenberg University Mainz</institution>,<addr-line>Mainz</addr-line>,<country>Germany</country>,</aff><aff id="af28"><label>28</label><addr-line>Department of Biological Psychology, Netherlands Twin Register</addr-line>,<institution>VU University</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af29"><label>29</label><addr-line>Department of Cardiology</addr-line>,</aff><aff id="af30"><label>30</label><addr-line>Department of Gerontology and Geriatrics</addr-line> and</aff><aff id="af31"><label>31</label><addr-line>Department of Molecular Epidemiology</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country>,</aff><aff id="af32"><label>32</label><addr-line>Institute of Genetic Epidemiology</addr-line>,</aff><aff id="af33"><label>33</label><addr-line>Institute of Epidemiology II</addr-line> and</aff><aff id="af34"><label>34</label><addr-line>Research Unit of Molecular Epidemiology</addr-line>,<institution>Helmholtz ZentrumMünchen – German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</aff><aff id="af35"><label>35</label><addr-line>Department of Medicine I</addr-line>,<institution>Ludwig-Maximilians-University Munich</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</aff><aff id="af36"><label>36</label><addr-line>DZHK (German Centre for Cardiovascular Research)</addr-line> and</aff><aff id="af37"><label>37</label><addr-line>German Centre for Cardiovascular Research (DZHK)</addr-line>,<institution>Partner Site Munich Heart Alliance</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</aff><aff id="af38"><label>38</label><addr-line>MRC Epidemiology Unit</addr-line>,<institution>School of Clinical Medicine</institution> and,</aff><aff id="af39"><label>39</label><addr-line>Clinical Gerontology Unit</addr-line>,<institution>School of Clinical Medicine, University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</aff><aff id="af40"><label>40</label><addr-line>Department of Medicine</addr-line>,</aff><aff id="af41"><label>41</label><addr-line>Department of Biostatistics</addr-line>,</aff><aff id="af42"><label>42</label><addr-line>Department of Medicine, Epidemiology, and Health Services</addr-line> and</aff><aff id="af43"><label>43</label><addr-line>Department of Epidemiology</addr-line>,<institution>University of Washington</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</aff><aff id="af44"><label>44</label><addr-line>Vth Department of Medicine, Medical Faculty Mannheim</addr-line>,<institution>Heidelberg University</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</aff><aff id="af45"><label>45</label><addr-line>Institute for Translational Genomics and Population Sciences</addr-line> and</aff><aff id="af46"><label>46</label><addr-line>Department of Pediatrics</addr-line>,<institution>Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center</institution>,<addr-line>Torrance, CA</addr-line>,<country>USA</country>,</aff><aff id="af47"><label>47</label><addr-line>Department of Ophthalmology</addr-line>,<institution>Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</aff><aff id="af48"><label>48</label><addr-line>Zilber School of Public Health</addr-line>,<institution>University of Wisconsin-Milwaukee</institution>,<addr-line>Milwaukee, WI</addr-line>,<country>USA</country>,</aff><aff id="af49"><label>49</label><addr-line>Public Health Stream</addr-line> and</aff><aff id="af50"><label>50</label><addr-line>Information based Medicine Program</addr-line>,<institution>Hunter Medical Research Institute</institution>,<addr-line>New Lambton Heights</addr-line>,<country>Australia</country>,</aff><aff id="af51"><label>51</label><addr-line>School of Medicine and Public Health</addr-line><country>and</country></aff><aff id="af52"><label>52</label><addr-line>School of Biomedical Sciences and Pharmacy</addr-line>,<institution>University of Newcastle</institution>,<addr-line>New Lambton Heights</addr-line>,<country>Australia</country>,</aff><aff id="af53"><label>53</label><addr-line>Department of Medicine</addr-line>,<institution>Johns Hopkins University School of Medicine</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</aff><aff id="af54"><label>54</label><addr-line>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences</addr-line><country>and</country></aff><aff id="af55"><label>55</label><addr-line>Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</aff><aff id="af56"><label>56</label><addr-line>The Danish Pediatric Asthma Center</addr-line>,<institution>Gentofte Hospital, The Capital Region</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</aff><aff id="af57"><label>57</label><addr-line>Institute of Behavioural Sciences</addr-line>,</aff><aff id="af58"><label>58</label><addr-line>Institute for Molecular Medicine Finland (FIMM)</addr-line> and</aff><aff id="af59"><label>59</label><addr-line>Department of General Practice and Primary Health Care</addr-line>,<institution>University of Helsinki</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="af60"><label>60</label><institution>Folkhälsan Research Centre</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="af61"><label>61</label><addr-line>Institute of Opthalmology</addr-line>,<institution>UCL</institution>,<addr-line>London</addr-line>,<country>UK</country>,</aff><aff id="af62"><label>62</label><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>Kings College London</institution>,<addr-line>London</addr-line>,<country>UK</country>,</aff><aff id="af63"><label>63</label><addr-line>Translational Gerontology Branch</addr-line>,<institution>National Institute on Aging</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</aff><aff id="af64"><label>64</label><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</aff><aff id="af65"><label>65</label><institution>Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</aff><aff id="af66"><label>66</label><institution>Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</aff><aff id="af67"><label>67</label><institution>Institute for Cardiometabolism and Nutrition (ICAN)</institution>,<addr-line>Paris F-75013</addr-line>,<country>France</country>,</aff><aff id="af68"><label>68</label><addr-line>Department of Public Health, Faculty of Medicine</addr-line>,</aff><aff id="af69"><label>69</label><addr-line>Department of Biology, School of Medicine</addr-line><country>and</country></aff><aff id="af70"><label>70</label><addr-line>Department of Public Health</addr-line>,<addr-line>Faculty of Medicine</addr-line>,<institution>Centre for Global Health, University of Split</institution>,<addr-line>Split</addr-line>,<country>Croatia</country>,</aff><aff id="af71"><label>71</label><addr-line>Cardiovascular Medicine Department/Radcliffe Department of Medicine</addr-line>,<institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</aff><aff id="af72"><label>72</label><addr-line>Department of Biostatistics</addr-line>,<institution>Boston University School of Public Health</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af73"><label>73</label><addr-line>Department of Genetics</addr-line>,<institution>School of Medicine, Mashhad University of Medical Sciences</institution>,<addr-line>Mashhad</addr-line>,<country>Iran</country>,</aff><aff id="af74"><label>74</label><addr-line>Institute of Cardiovascular and Medical Sciences</addr-line><country>and</country></aff><aff id="af75"><label>75</label><addr-line>Institute of Cardiovascular and Medical Sciences</addr-line>,<institution>Faculty of Medicine, University of Glasgow</institution>,<addr-line>Glasgow</addr-line>,<country>UK</country>,</aff><aff id="af76"><label>76</label><institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</aff><aff id="af77"><label>77</label><addr-line>Department of Psychiatry</addr-line>,<institution>Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital</institution>,<addr-line>Dublin</addr-line>,<country>Ireland</country>,</aff><aff id="af78"><label>78</label><institution>University College Dublin, UCD Conway Institute, Centre for Proteome Research, UCD</institution>,<addr-line>Belfield, Dublin</addr-line>,<country>Ireland</country>,</aff><aff id="af79"><label>79</label><addr-line>Institute of Preventive Medicine</addr-line>,<institution>Bispebjerg and Frederiksberg Hospital, The Capital Region</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</aff><aff id="af80"><label>80</label><addr-line>Geriatric Unit</addr-line>,<institution>Azienda Sanitaria Firenze (ASF)</institution>,<addr-line>Florence</addr-line>,<country>Italy</country>,</aff><aff id="af81"><label>81</label><addr-line>Human Genetics Center</addr-line>,<institution>University of Texas Health Science Center at Houston</institution>,<addr-line>Houston, TX</addr-line>,<country>USA</country>,</aff><aff id="af82"><label>82</label><addr-line>Royal North Shore Hospital</addr-line>,<institution>Sydney University</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</aff><aff id="af83"><label>83</label><addr-line>EMGO+ institute</addr-line>,<institution>VU University & VU Medical Center</institution>,<addr-line>Amsterdam</addr-line>,</aff><aff id="af84"><label>84</label><addr-line>Faculty of Medicine</addr-line>,<institution>BHF Glasgow Cardiovascular Research Centre</institution>,<addr-line>Glasgow</addr-line>,<country>UK</country>,</aff><aff id="af85"><label>85</label><addr-line>Department of Human Genetics</addr-line>,<institution>Wellcome Trust Sanger Institute</institution>,<addr-line>Hinxton, Cambridge</addr-line>,<country>UK</country>,</aff><aff id="af86"><label>86</label><addr-line>Department of Pathology and Laboratory Medicine</addr-line><country>and</country>,</aff><aff id="af87"><label>87</label><addr-line>Department of Pathology and Laboratory Medicine</addr-line>,<institution>Center for Clinical and Translational Sciences, University of Vermont College of Medicine</institution>,<addr-line>Colchester, VT</addr-line>,<country>USA</country>,</aff><aff id="af88"><label>88</label><addr-line>Public Health Stream</addr-line>,<institution>Hunter Medical Research Institute, School of Medicine and Public Health</institution><country>and</country></aff><aff id="af89"><label>89</label><addr-line>School of Medicine and Public Health</addr-line>,<institution>University of Newcastle</institution>,<addr-line>Newcastle</addr-line>,<country>Australia</country>,</aff><aff id="af90"><label>90</label><addr-line>Division of Biostatistics, Department of Public Health Sciences</addr-line>,<institution>UC Davis</institution>,<addr-line>Davis, CA</addr-line>,<country>USA</country>,</aff><aff id="af91"><label>91</label><addr-line>Public Health Genomics Unit</addr-line>,<institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="af92"><label>92</label><addr-line>Laboratory of Neurogenetics</addr-line>,<institution>National Institute on Aging</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</aff><aff id="af93"><label>93</label><addr-line>School of Social and Community Medicine</addr-line>,<institution>University of Bristol</institution>,<addr-line>Bristol</addr-line>,<country>UK</country>,</aff><aff id="af94"><label>94</label><addr-line>Department of General and Interventional Cardiology</addr-line>,<institution>University Heart Centre, University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</aff><aff id="af95"><label>95</label><institution>German Center for Cardiovascular Research (DZHK), Partner Site Hamburg</institution>,<addr-line>Lübeck, Kiel, Hamburg</addr-line>,<country>Germany</country>,</aff><aff id="af96"><label>96</label><addr-line>Department of Internal Medicine II – Cardiology</addr-line>,<institution>University of Ulm Medical Centre</institution>,<addr-line>Ulm</addr-line>,<country>Germany</country>,</aff><aff id="af97"><label>97</label><addr-line>Deutsches Herzzentrum München</addr-line>,<institution>Technische Universität München</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</aff><aff id="af98"><label>98</label><institution>Group Health Research Institute, Group Health Cooperative</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</aff><aff id="af99"><label>99</label><addr-line>Inflammatory Bowel & Immunobiology Research Institute</addr-line>,<institution>Cedars-Sinai Medical Center</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</aff><aff id="af100"><label>100</label><addr-line>Laboratory of Haematology</addr-line>,<institution>La Timone Hospital</institution>,<addr-line>Marseille F-13385</addr-line>,<country>France</country>,</aff><aff id="af101"><label>101</label><institution>INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis</institution>,<addr-line>Marseille F-13385</addr-line>,<country>France</country>,</aff><aff id="af102"><label>102</label><institution>Aix-Marseille University, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis</institution>,<addr-line>Marseille F-13385</addr-line>,<country>France</country>,</aff><aff id="af103"><label>103</label><institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="af104"><label>104</label><addr-line>Unit of General Practice</addr-line>,<institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="af105"><label>105</label><addr-line>Synlab Academy</addr-line>,<institution>Synlab Services LLC</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</aff><aff id="af106"><label>106</label><addr-line>Clinical Institute of Medical</addr-line>,<addr-line>Chemical Laboratory Diagnostics</addr-line>,<institution>Medical University of Graz</institution>,<addr-line>Graz</addr-line>,<country>Austria</country>,</aff><aff id="af107"><label>107</label><addr-line>German Center for Cardiovascular Research (DZHK)</addr-line>,<institution>Partner Site RheinMain</institution>,<addr-line>Mainz</addr-line>,<country>Germany</country>,</aff><aff id="af108"><label>108</label><institution>Durrer Center for Cardiogenetic Research</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af109"><label>109</label><institution>Interuniversity Cardiology Institute of The Netherlands</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country>,</aff><aff id="af110"><label>110</label><institution>University of Washington</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</aff><aff id="af111"><label>111</label><institution>National Heart, Lung and Blood Institute, Division of Intramural Research</institution>,</aff><aff id="af112"><label>112</label><addr-line>Cardiology Division</addr-line>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af113"><label>113</label><addr-line>Department of Veterans Affairs</addr-line>,<institution>Office of Research and Development, Seattle Epidemiologic Research and Information Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country> and</aff><aff id="af114"><label>114</label><addr-line>Population Health Research Institute, St George's</addr-line><institution>University of London</institution>,<addr-line>London</addr-line>,<country>UK</country></aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>To whom correspondence should be addressed. Tel: +31 107043997; Fax: +31 107044657; Email: <email>a.dehghan@erasmusmc.nl</email></corresp><fn id="AN1" fn-type="con"><label>†</label><p>D.P.S. and A.D. contributed equally to this study as senior authors.</p></fn></author-notes><pub-date pub-type="ppub"><day>15</day><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>10</day><month>11</month><year>2015</year></pub-date><volume>25</volume><issue>2</issue><fpage>358</fpage><lpage>370</lpage><history><date date-type="received"><day>14</day><month>7</month><year>2015</year></date><date date-type="rev-recd"><day>6</day><month>10</month><year>2015</year></date><date date-type="accepted"><day>27</day><month>10</month><year>2015</year></date></history><permissions><copyright-statement>© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2015</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="ddv454.pdf"></self-uri><abstract><p>Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: <italic>FGB</italic> and <italic>IRF1</italic>. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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