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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci</title><author><name sortKey="Kachuri, Linda" sort="Kachuri, Linda" uniqKey="Kachuri L" first="Linda" last="Kachuri">Linda Kachuri</name><affiliation><nlm:aff id="AF0001"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3L9</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002"><institution>Division of Epidemiology</institution>,<institution>Dalla Lana School of Public Health</institution>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3M7</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><affiliation><nlm:aff id="AF0003"><institution>Department of Community and Family Medicine</institution>,<institution>Center for Genomic Medicine</institution>,<institution>Geisel School of Medicine</institution>,<institution>Dartmouth College</institution>,<addr-line>Lebanon</addr-line>,<addr-line>NH 03766</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D." last="Mckay">James D. Mckay</name><affiliation><nlm:aff id="AF0004"><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon, CEDEX 08, 69372</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation><nlm:aff id="AF0004"><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon, CEDEX 08, 69372</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation><nlm:aff id="AF0005"><institution>Human Genetics Foundation (HuGeF), 10126</institution><addr-line>Torino</addr-line>,<country>Italy</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0006"><institution>Department of Epidemiology and Biostatistics</institution>,<institution>MRC-PHE Centre for Environment and Health</institution>,<institution>School of Public Health, Imperial College London</institution>,<addr-line>Norfolk Place</addr-line>,<addr-line>London W2 1PG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation><nlm:aff id="AF0007"><institution>Department for Determinants of Chronic Diseases (DCD)</institution>,<institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>3721 MA Bilthoven</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0008"><institution>Department of Gastroenterology and Hepatology</institution>,<institution>University Medical Centre</institution>,<addr-line>3584 CX Utrecht</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0009"><institution>Department of Epidemiology and Biostatistics</institution>,<institution>The School of Public Health</institution>,<institution>Imperial College London</institution>,<addr-line>London SW7 2AZ</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0010"><institution>Department of Social and Preventive Medicine</institution>,<institution>Faculty of Medicine</institution>,<institution>University of Malaya</institution>,<addr-line>Kuala Lumpur 50603</addr-line>,<country>Malaysia</country>,</nlm:aff></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation><nlm:aff id="AF0011"><institution>INSERM</institution>,<institution>Centre for Research in Epidemiology and Population Health (CESP), U1018, Lifestyle, Genes and Health: Integrative Trans-Generational Epidemiology</institution>,<addr-line>94805 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0012"><institution>Université Paris Sud</institution>,<addr-line>UMRS 1018 94805, Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0013"><institution>Institut Gustave Roussy</institution><addr-line>F-94805, Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Johansson, Mikael" sort="Johansson, Mikael" uniqKey="Johansson M" first="Mikael" last="Johansson">Mikael Johansson</name><affiliation><nlm:aff id="AF0014"><institution>Department of Radiation Sciences</institution>,<institution>Umeå University</institution>,<addr-line>Umeå SE-901 87</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Quir S, J Ram N" sort="Quir S, J Ram N" uniqKey="Quir S J" first="J. Ram N" last="Quir S">J. Ram N Quir S</name><affiliation><nlm:aff id="AF0015"><institution>Public Health Directorate Asturias</institution>,<addr-line> CP 33006 Oviedo</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name><affiliation><nlm:aff id="AF0016"><institution>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori</institution>,<addr-line>20133 Milano</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="AF0017"><institution>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford</institution>,<addr-line>Oxford OX3 7LF</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:aff id="AF0018"><institution>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway</institution>,<addr-line>9037 Tromsø</addr-line>,<country>Norway</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0019"><institution>Department of Research, Cancer Registry of Norway</institution>,<addr-line>0379 Oslo</addr-line>,<country>Norway</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0020"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm SE-171 77</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0021"><institution>Genetic Epidemiology Group, Folkhälsan Research Center</institution>,<addr-line>Helsinki FI-00014</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="AF0022"><institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI 96813</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="AF0022"><institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI 96813</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wilkens, Lynne" sort="Wilkens, Lynne" uniqKey="Wilkens L" first="Lynne" last="Wilkens">Lynne Wilkens</name><affiliation><nlm:aff id="AF0022"><institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI 96813</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Goodman, Gary E" sort="Goodman, Gary E" uniqKey="Goodman G" first="Gary E." last="Goodman">Gary E. Goodman</name><affiliation><nlm:aff id="AF0023"><institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle</addr-line>,<addr-line>WA 98109</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name><affiliation><nlm:aff id="AF0023"><institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle</addr-line>,<addr-line>WA 98109</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Doherty, Jennifer A" sort="Doherty, Jennifer A" uniqKey="Doherty J" first="Jennifer A." last="Doherty">Jennifer A. Doherty</name><affiliation><nlm:aff id="AF0003"><institution>Department of Community and Family Medicine</institution>,<institution>Center for Genomic Medicine</institution>,<institution>Geisel School of Medicine</institution>,<institution>Dartmouth College</institution>,<addr-line>Lebanon</addr-line>,<addr-line>NH 03766</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C." last="Christiani">David C. Christiani</name><affiliation><nlm:aff id="AF0024"><institution>Departments of Environmental Health and Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0025"><institution>Department of Medicine, Massachusetts General Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA 02114</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name><affiliation><nlm:aff id="AF0024"><institution>Departments of Environmental Health and Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Su, Li" sort="Su, Li" uniqKey="Su L" first="Li" last="Su">Li Su</name><affiliation><nlm:aff id="AF0024"><institution>Departments of Environmental Health and Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Tworoger, Shelley" sort="Tworoger, Shelley" uniqKey="Tworoger S" first="Shelley" last="Tworoger">Shelley Tworoger</name><affiliation><nlm:aff id="AF0024"><institution>Departments of Environmental Health and Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0026"><institution>Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School</institution>,<addr-line>Boston</addr-line>,<addr-line>MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Zhang, Xuehong" sort="Zhang, Xuehong" uniqKey="Zhang X" first="Xuehong" last="Zhang">Xuehong Zhang</name><affiliation><nlm:aff id="AF0026"><institution>Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School</institution>,<addr-line>Boston</addr-line>,<addr-line>MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="AF0027"><institution>Departments of Biostatistics and Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Zaridze, David" sort="Zaridze, David" uniqKey="Zaridze D" first="David" last="Zaridze">David Zaridze</name><affiliation><nlm:aff id="AF0028"><institution>Russian Cancer Research Center</institution>,<addr-line>Moscow 115478</addr-line>,<country>Russia</country>,</nlm:aff></affiliation></author><author><name sortKey="Field, John K" sort="Field, John K" uniqKey="Field J" first="John K." last="Field">John K. Field</name><affiliation><nlm:aff id="AF0029"><institution>Roy Castle Lung Cancer Research Programme</institution>,<institution>University of Liverpool Cancer Research Centre Institute of Translational Medicine</institution>,<institution>University of Liverpool</institution>,<addr-line>Liverpool L69 3BX</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Marcus, Michael W" sort="Marcus, Michael W" uniqKey="Marcus M" first="Michael W." last="Marcus">Michael W. Marcus</name><affiliation><nlm:aff id="AF0029"><institution>Roy Castle Lung Cancer Research Programme</institution>,<institution>University of Liverpool Cancer Research Centre Institute of Translational Medicine</institution>,<institution>University of Liverpool</institution>,<addr-line>Liverpool L69 3BX</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Davies, Michael P A" sort="Davies, Michael P A" uniqKey="Davies M" first="Michael P. A." last="Davies">Michael P. A. Davies</name><affiliation><nlm:aff id="AF0029"><institution>Roy Castle Lung Cancer Research Programme</institution>,<institution>University of Liverpool Cancer Research Centre Institute of Translational Medicine</institution>,<institution>University of Liverpool</institution>,<addr-line>Liverpool L69 3BX</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hyde, Russell" sort="Hyde, Russell" uniqKey="Hyde R" first="Russell" last="Hyde">Russell Hyde</name><affiliation><nlm:aff id="AF0029"><institution>Roy Castle Lung Cancer Research Programme</institution>,<institution>University of Liverpool Cancer Research Centre Institute of Translational Medicine</institution>,<institution>University of Liverpool</institution>,<addr-line>Liverpool L69 3BX</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E." last="Caporaso">Neil E. Caporaso</name><affiliation><nlm:aff id="AF0030"><institution>Division of Cancer Epidemiology and Genetics</institution>,<institution>National Cancer Institute</institution>,<institution>National Institutes of Health</institution>,<institution>Department of Health and Human Services</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD 20892</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation><nlm:aff id="AF0030"><institution>Division of Cancer Epidemiology and Genetics</institution>,<institution>National Cancer Institute</institution>,<institution>National Institutes of Health</institution>,<institution>Department of Health and Human Services</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD 20892</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="AF0005"><institution>Human Genetics Foundation (HuGeF), 10126</institution><addr-line>Torino</addr-line>,<country>Italy</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0011"><institution>INSERM</institution>,<institution>Centre for Research in Epidemiology and Population Health (CESP), U1018, Lifestyle, Genes and Health: Integrative Trans-Generational Epidemiology</institution>,<addr-line>94805 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0012"><institution>Université Paris Sud</institution>,<addr-line>UMRS 1018 94805, Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0013"><institution>Institut Gustave Roussy</institution><addr-line>F-94805, Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0031"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Melbourne 3004</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0032"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution>,<institution>University of Melbourne</institution>,<country>Melbourne 3010, Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="AF0031"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Melbourne 3004</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0032"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution>,<institution>University of Melbourne</institution>,<country>Melbourne 3010, Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0033"><institution>Department of Epidemiology and Preventive Medicine</institution>,<institution>Monash University</institution>,<addr-line>Melbourne 3004</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Liu, Geoffrey" sort="Liu, Geoffrey" uniqKey="Liu G" first="Geoffrey" last="Liu">Geoffrey Liu</name><affiliation><nlm:aff id="AF0002"><institution>Division of Epidemiology</institution>,<institution>Dalla Lana School of Public Health</institution>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3M7</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0034"><institution>Ontario Cancer Institute</institution>,<institution>Princess Margaret Cancer Center</institution>,<addr-line>Toronto, Ontario M5G 0A3</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Mclaughlin, John R" sort="Mclaughlin, John R" uniqKey="Mclaughlin J" first="John R." last="Mclaughlin">John R. Mclaughlin</name><affiliation><nlm:aff id="AF0001"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3L9</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="AF0035"><institution>Public Health Ontario</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5G 1V2</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Li, Yafang" sort="Li, Yafang" uniqKey="Li Y" first="Yafang" last="Li">Yafang Li</name><affiliation><nlm:aff id="AF0003"><institution>Department of Community and Family Medicine</institution>,<institution>Center for Genomic Medicine</institution>,<institution>Geisel School of Medicine</institution>,<institution>Dartmouth College</institution>,<addr-line>Lebanon</addr-line>,<addr-line>NH 03766</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Xiao, Xiangjun" sort="Xiao, Xiangjun" uniqKey="Xiao X" first="Xiangjun" last="Xiao">Xiangjun Xiao</name><affiliation><nlm:aff id="AF0003"><institution>Department of Community and Family Medicine</institution>,<institution>Center for Genomic Medicine</institution>,<institution>Geisel School of Medicine</institution>,<institution>Dartmouth College</institution>,<addr-line>Lebanon</addr-line>,<addr-line>NH 03766</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Fehringer, Gord" sort="Fehringer, Gord" uniqKey="Fehringer G" first="Gord" last="Fehringer">Gord Fehringer</name><affiliation><nlm:aff id="AF0001"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3L9</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Zong, Xuchen" sort="Zong, Xuchen" uniqKey="Zong X" first="Xuchen" last="Zong">Xuchen Zong</name><affiliation><nlm:aff id="AF0001"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3L9</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Denroche, Robert E" sort="Denroche, Robert E" uniqKey="Denroche R" first="Robert E." last="Denroche">Robert E. Denroche</name><affiliation><nlm:aff id="AF0036"><institution>Genome Technologies, Ontario Institute for Cancer Research</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5G 0A3</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Zuzarte, Philip C" sort="Zuzarte, Philip C" uniqKey="Zuzarte P" first="Philip C." last="Zuzarte">Philip C. Zuzarte</name><affiliation><nlm:aff id="AF0036"><institution>Genome Technologies, Ontario Institute for Cancer Research</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5G 0A3</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Mcpherson, John D" sort="Mcpherson, John D" uniqKey="Mcpherson J" first="John D." last="Mcpherson">John D. Mcpherson</name><affiliation><nlm:aff id="AF0036"><institution>Genome Technologies, Ontario Institute for Cancer Research</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5G 0A3</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="AF0004"><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon, CEDEX 08, 69372</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J." last="Hung">Rayjean J. Hung</name><affiliation><nlm:aff id="AF0001"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3L9</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002"><institution>Division of Epidemiology</institution>,<institution>Dalla Lana School of Public Health</institution>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3M7</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26590902</idno><idno type="pmc">4715236</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715236</idno><idno type="RBID">PMC:4715236</idno><idno type="doi">10.1093/carcin/bgv165</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000439</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000439</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci</title><author><name sortKey="Kachuri, Linda" sort="Kachuri, Linda" uniqKey="Kachuri L" first="Linda" last="Kachuri">Linda Kachuri</name><affiliation><nlm:aff id="AF0001"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3L9</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002"><institution>Division of Epidemiology</institution>,<institution>Dalla Lana School of Public Health</institution>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3M7</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><affiliation><nlm:aff id="AF0003"><institution>Department of Community and Family Medicine</institution>,<institution>Center for Genomic Medicine</institution>,<institution>Geisel School of Medicine</institution>,<institution>Dartmouth College</institution>,<addr-line>Lebanon</addr-line>,<addr-line>NH 03766</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D." last="Mckay">James D. Mckay</name><affiliation><nlm:aff id="AF0004"><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon, CEDEX 08, 69372</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation><nlm:aff id="AF0004"><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon, CEDEX 08, 69372</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation><nlm:aff id="AF0005"><institution>Human Genetics Foundation (HuGeF), 10126</institution><addr-line>Torino</addr-line>,<country>Italy</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0006"><institution>Department of Epidemiology and Biostatistics</institution>,<institution>MRC-PHE Centre for Environment and Health</institution>,<institution>School of Public Health, Imperial College London</institution>,<addr-line>Norfolk Place</addr-line>,<addr-line>London W2 1PG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation><nlm:aff id="AF0007"><institution>Department for Determinants of Chronic Diseases (DCD)</institution>,<institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>3721 MA Bilthoven</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0008"><institution>Department of Gastroenterology and Hepatology</institution>,<institution>University Medical Centre</institution>,<addr-line>3584 CX Utrecht</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0009"><institution>Department of Epidemiology and Biostatistics</institution>,<institution>The School of Public Health</institution>,<institution>Imperial College London</institution>,<addr-line>London SW7 2AZ</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0010"><institution>Department of Social and Preventive Medicine</institution>,<institution>Faculty of Medicine</institution>,<institution>University of Malaya</institution>,<addr-line>Kuala Lumpur 50603</addr-line>,<country>Malaysia</country>,</nlm:aff></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation><nlm:aff id="AF0011"><institution>INSERM</institution>,<institution>Centre for Research in Epidemiology and Population Health (CESP), U1018, Lifestyle, Genes and Health: Integrative Trans-Generational Epidemiology</institution>,<addr-line>94805 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0012"><institution>Université Paris Sud</institution>,<addr-line>UMRS 1018 94805, Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0013"><institution>Institut Gustave Roussy</institution><addr-line>F-94805, Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Johansson, Mikael" sort="Johansson, Mikael" uniqKey="Johansson M" first="Mikael" last="Johansson">Mikael Johansson</name><affiliation><nlm:aff id="AF0014"><institution>Department of Radiation Sciences</institution>,<institution>Umeå University</institution>,<addr-line>Umeå SE-901 87</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Quir S, J Ram N" sort="Quir S, J Ram N" uniqKey="Quir S J" first="J. Ram N" last="Quir S">J. Ram N Quir S</name><affiliation><nlm:aff id="AF0015"><institution>Public Health Directorate Asturias</institution>,<addr-line> CP 33006 Oviedo</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name><affiliation><nlm:aff id="AF0016"><institution>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori</institution>,<addr-line>20133 Milano</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="AF0017"><institution>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford</institution>,<addr-line>Oxford OX3 7LF</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:aff id="AF0018"><institution>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway</institution>,<addr-line>9037 Tromsø</addr-line>,<country>Norway</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0019"><institution>Department of Research, Cancer Registry of Norway</institution>,<addr-line>0379 Oslo</addr-line>,<country>Norway</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0020"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm SE-171 77</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0021"><institution>Genetic Epidemiology Group, Folkhälsan Research Center</institution>,<addr-line>Helsinki FI-00014</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="AF0022"><institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI 96813</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="AF0022"><institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI 96813</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wilkens, Lynne" sort="Wilkens, Lynne" uniqKey="Wilkens L" first="Lynne" last="Wilkens">Lynne Wilkens</name><affiliation><nlm:aff id="AF0022"><institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI 96813</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Goodman, Gary E" sort="Goodman, Gary E" uniqKey="Goodman G" first="Gary E." last="Goodman">Gary E. Goodman</name><affiliation><nlm:aff id="AF0023"><institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle</addr-line>,<addr-line>WA 98109</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name><affiliation><nlm:aff id="AF0023"><institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle</addr-line>,<addr-line>WA 98109</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Doherty, Jennifer A" sort="Doherty, Jennifer A" uniqKey="Doherty J" first="Jennifer A." last="Doherty">Jennifer A. Doherty</name><affiliation><nlm:aff id="AF0003"><institution>Department of Community and Family Medicine</institution>,<institution>Center for Genomic Medicine</institution>,<institution>Geisel School of Medicine</institution>,<institution>Dartmouth College</institution>,<addr-line>Lebanon</addr-line>,<addr-line>NH 03766</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C." last="Christiani">David C. Christiani</name><affiliation><nlm:aff id="AF0024"><institution>Departments of Environmental Health and Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0025"><institution>Department of Medicine, Massachusetts General Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA 02114</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name><affiliation><nlm:aff id="AF0024"><institution>Departments of Environmental Health and Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Su, Li" sort="Su, Li" uniqKey="Su L" first="Li" last="Su">Li Su</name><affiliation><nlm:aff id="AF0024"><institution>Departments of Environmental Health and Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Tworoger, Shelley" sort="Tworoger, Shelley" uniqKey="Tworoger S" first="Shelley" last="Tworoger">Shelley Tworoger</name><affiliation><nlm:aff id="AF0024"><institution>Departments of Environmental Health and Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0026"><institution>Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School</institution>,<addr-line>Boston</addr-line>,<addr-line>MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Zhang, Xuehong" sort="Zhang, Xuehong" uniqKey="Zhang X" first="Xuehong" last="Zhang">Xuehong Zhang</name><affiliation><nlm:aff id="AF0026"><institution>Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School</institution>,<addr-line>Boston</addr-line>,<addr-line>MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="AF0027"><institution>Departments of Biostatistics and Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Zaridze, David" sort="Zaridze, David" uniqKey="Zaridze D" first="David" last="Zaridze">David Zaridze</name><affiliation><nlm:aff id="AF0028"><institution>Russian Cancer Research Center</institution>,<addr-line>Moscow 115478</addr-line>,<country>Russia</country>,</nlm:aff></affiliation></author><author><name sortKey="Field, John K" sort="Field, John K" uniqKey="Field J" first="John K." last="Field">John K. Field</name><affiliation><nlm:aff id="AF0029"><institution>Roy Castle Lung Cancer Research Programme</institution>,<institution>University of Liverpool Cancer Research Centre Institute of Translational Medicine</institution>,<institution>University of Liverpool</institution>,<addr-line>Liverpool L69 3BX</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Marcus, Michael W" sort="Marcus, Michael W" uniqKey="Marcus M" first="Michael W." last="Marcus">Michael W. Marcus</name><affiliation><nlm:aff id="AF0029"><institution>Roy Castle Lung Cancer Research Programme</institution>,<institution>University of Liverpool Cancer Research Centre Institute of Translational Medicine</institution>,<institution>University of Liverpool</institution>,<addr-line>Liverpool L69 3BX</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Davies, Michael P A" sort="Davies, Michael P A" uniqKey="Davies M" first="Michael P. A." last="Davies">Michael P. A. Davies</name><affiliation><nlm:aff id="AF0029"><institution>Roy Castle Lung Cancer Research Programme</institution>,<institution>University of Liverpool Cancer Research Centre Institute of Translational Medicine</institution>,<institution>University of Liverpool</institution>,<addr-line>Liverpool L69 3BX</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hyde, Russell" sort="Hyde, Russell" uniqKey="Hyde R" first="Russell" last="Hyde">Russell Hyde</name><affiliation><nlm:aff id="AF0029"><institution>Roy Castle Lung Cancer Research Programme</institution>,<institution>University of Liverpool Cancer Research Centre Institute of Translational Medicine</institution>,<institution>University of Liverpool</institution>,<addr-line>Liverpool L69 3BX</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E." last="Caporaso">Neil E. Caporaso</name><affiliation><nlm:aff id="AF0030"><institution>Division of Cancer Epidemiology and Genetics</institution>,<institution>National Cancer Institute</institution>,<institution>National Institutes of Health</institution>,<institution>Department of Health and Human Services</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD 20892</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation><nlm:aff id="AF0030"><institution>Division of Cancer Epidemiology and Genetics</institution>,<institution>National Cancer Institute</institution>,<institution>National Institutes of Health</institution>,<institution>Department of Health and Human Services</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD 20892</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="AF0005"><institution>Human Genetics Foundation (HuGeF), 10126</institution><addr-line>Torino</addr-line>,<country>Italy</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0011"><institution>INSERM</institution>,<institution>Centre for Research in Epidemiology and Population Health (CESP), U1018, Lifestyle, Genes and Health: Integrative Trans-Generational Epidemiology</institution>,<addr-line>94805 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0012"><institution>Université Paris Sud</institution>,<addr-line>UMRS 1018 94805, Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0013"><institution>Institut Gustave Roussy</institution><addr-line>F-94805, Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0031"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Melbourne 3004</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0032"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution>,<institution>University of Melbourne</institution>,<country>Melbourne 3010, Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="AF0031"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Melbourne 3004</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0032"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution>,<institution>University of Melbourne</institution>,<country>Melbourne 3010, Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0033"><institution>Department of Epidemiology and Preventive Medicine</institution>,<institution>Monash University</institution>,<addr-line>Melbourne 3004</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Liu, Geoffrey" sort="Liu, Geoffrey" uniqKey="Liu G" first="Geoffrey" last="Liu">Geoffrey Liu</name><affiliation><nlm:aff id="AF0002"><institution>Division of Epidemiology</institution>,<institution>Dalla Lana School of Public Health</institution>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3M7</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0034"><institution>Ontario Cancer Institute</institution>,<institution>Princess Margaret Cancer Center</institution>,<addr-line>Toronto, Ontario M5G 0A3</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Mclaughlin, John R" sort="Mclaughlin, John R" uniqKey="Mclaughlin J" first="John R." last="Mclaughlin">John R. Mclaughlin</name><affiliation><nlm:aff id="AF0001"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3L9</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="AF0035"><institution>Public Health Ontario</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5G 1V2</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Li, Yafang" sort="Li, Yafang" uniqKey="Li Y" first="Yafang" last="Li">Yafang Li</name><affiliation><nlm:aff id="AF0003"><institution>Department of Community and Family Medicine</institution>,<institution>Center for Genomic Medicine</institution>,<institution>Geisel School of Medicine</institution>,<institution>Dartmouth College</institution>,<addr-line>Lebanon</addr-line>,<addr-line>NH 03766</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Xiao, Xiangjun" sort="Xiao, Xiangjun" uniqKey="Xiao X" first="Xiangjun" last="Xiao">Xiangjun Xiao</name><affiliation><nlm:aff id="AF0003"><institution>Department of Community and Family Medicine</institution>,<institution>Center for Genomic Medicine</institution>,<institution>Geisel School of Medicine</institution>,<institution>Dartmouth College</institution>,<addr-line>Lebanon</addr-line>,<addr-line>NH 03766</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Fehringer, Gord" sort="Fehringer, Gord" uniqKey="Fehringer G" first="Gord" last="Fehringer">Gord Fehringer</name><affiliation><nlm:aff id="AF0001"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3L9</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Zong, Xuchen" sort="Zong, Xuchen" uniqKey="Zong X" first="Xuchen" last="Zong">Xuchen Zong</name><affiliation><nlm:aff id="AF0001"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3L9</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Denroche, Robert E" sort="Denroche, Robert E" uniqKey="Denroche R" first="Robert E." last="Denroche">Robert E. Denroche</name><affiliation><nlm:aff id="AF0036"><institution>Genome Technologies, Ontario Institute for Cancer Research</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5G 0A3</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Zuzarte, Philip C" sort="Zuzarte, Philip C" uniqKey="Zuzarte P" first="Philip C." last="Zuzarte">Philip C. Zuzarte</name><affiliation><nlm:aff id="AF0036"><institution>Genome Technologies, Ontario Institute for Cancer Research</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5G 0A3</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Mcpherson, John D" sort="Mcpherson, John D" uniqKey="Mcpherson J" first="John D." last="Mcpherson">John D. Mcpherson</name><affiliation><nlm:aff id="AF0036"><institution>Genome Technologies, Ontario Institute for Cancer Research</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5G 0A3</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="AF0004"><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon, CEDEX 08, 69372</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J." last="Hung">Rayjean J. Hung</name><affiliation><nlm:aff id="AF0001"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3L9</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002"><institution>Division of Epidemiology</institution>,<institution>Dalla Lana School of Public Health</institution>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3M7</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author></analytic><series><title level="j">Carcinogenesis</title><idno type="ISSN">0143-3334</idno><idno type="eISSN">1460-2180</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>Based on deep targeted sequencing and Axiom data in 10 lung cancer studies, our fine mapping analysis identified multiple novel lung cancer susceptibility variants in 5p15.33 region. It also demonstrated that telomere length is a key mechanism of these associations.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Carcinogenesis</journal-id><journal-id journal-id-type="iso-abbrev">Carcinogenesis</journal-id><journal-id journal-id-type="hwp">carcin</journal-id><journal-id journal-id-type="publisher-id">carcin</journal-id><journal-title-group><journal-title>Carcinogenesis</journal-title></journal-title-group><issn pub-type="ppub">0143-3334</issn><issn pub-type="epub">1460-2180</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26590902</article-id><article-id pub-id-type="pmc">4715236</article-id><article-id pub-id-type="doi">10.1093/carcin/bgv165</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Manuscript</subject></subj-group></article-categories><title-group><article-title>Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kachuri</surname><given-names>Linda</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Amos</surname><given-names>Christopher I.</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>McKay</surname><given-names>James D.</given-names></name><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Johansson</surname><given-names>Mattias</given-names></name><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vineis</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="AF0005"><sup>5</sup></xref><xref ref-type="aff" rid="AF0006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bueno-de-Mesquita</surname><given-names>H.Bas</given-names></name><xref ref-type="aff" rid="AF0007"><sup>7</sup></xref><xref ref-type="aff" rid="AF0008"><sup>8</sup></xref><xref ref-type="aff" rid="AF0009"><sup>9</sup></xref><xref ref-type="aff" rid="AF0010"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Boutron-Ruault</surname><given-names>Marie-Christine</given-names></name><xref ref-type="aff" rid="AF0011"><sup>11</sup></xref><xref ref-type="aff" rid="AF0012"><sup>12</sup></xref><xref ref-type="aff" rid="AF0013"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Johansson</surname><given-names>Mikael</given-names></name><xref ref-type="aff" rid="AF0014"><sup>14</sup></xref></contrib><contrib contrib-type="author"><name><surname>Quirós</surname><given-names>J.Ramón</given-names></name><xref ref-type="aff" rid="AF0015"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sieri</surname><given-names>Sabina</given-names></name><xref ref-type="aff" rid="AF0016"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Travis</surname><given-names>Ruth C.</given-names></name><xref ref-type="aff" rid="AF0017"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Weiderpass</surname><given-names>Elisabete</given-names></name><xref ref-type="aff" rid="AF0018"><sup>18</sup></xref><xref ref-type="aff" rid="AF0019"><sup>19</sup></xref><xref ref-type="aff" rid="AF0020"><sup>20</sup></xref><xref ref-type="aff" rid="AF0021"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Le Marchand</surname><given-names>Loic</given-names></name><xref ref-type="aff" rid="AF0022"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Henderson</surname><given-names>Brian E.</given-names></name><xref ref-type="aff" rid="AF0022"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wilkens</surname><given-names>Lynne</given-names></name><xref ref-type="aff" rid="AF0022"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Goodman</surname><given-names>Gary E.</given-names></name><xref ref-type="aff" rid="AF0023"><sup>23</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Chu</given-names></name><xref ref-type="aff" rid="AF0023"><sup>23</sup></xref></contrib><contrib contrib-type="author"><name><surname>Doherty</surname><given-names>Jennifer A.</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Christiani</surname><given-names>David C.</given-names></name><xref ref-type="aff" rid="AF0024"><sup>24</sup></xref><xref ref-type="aff" rid="AF0025"><sup>25</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wei</surname><given-names>Yongyue</given-names></name><xref ref-type="aff" rid="AF0024"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Su</surname><given-names>Li</given-names></name><xref ref-type="aff" rid="AF0024"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tworoger</surname><given-names>Shelley</given-names></name><xref ref-type="aff" rid="AF0024"><sup>24</sup></xref><xref ref-type="aff" rid="AF0026"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Xuehong</given-names></name><xref ref-type="aff" rid="AF0026"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kraft</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="AF0027"><sup>27</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zaridze</surname><given-names>David</given-names></name><xref ref-type="aff" rid="AF0028"><sup>28</sup></xref></contrib><contrib contrib-type="author"><name><surname>Field</surname><given-names>John K.</given-names></name><xref ref-type="aff" rid="AF0029"><sup>29</sup></xref></contrib><contrib contrib-type="author"><name><surname>Marcus</surname><given-names>Michael W.</given-names></name><xref ref-type="aff" rid="AF0029"><sup>29</sup></xref></contrib><contrib contrib-type="author"><name><surname>Davies</surname><given-names>Michael P.A.</given-names></name><xref ref-type="aff" rid="AF0029"><sup>29</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hyde</surname><given-names>Russell</given-names></name><xref ref-type="aff" rid="AF0029"><sup>29</sup></xref></contrib><contrib contrib-type="author"><name><surname>Caporaso</surname><given-names>Neil E.</given-names></name><xref ref-type="aff" rid="AF0030"><sup>30</sup></xref></contrib><contrib contrib-type="author"><name><surname>Landi</surname><given-names>Maria Teresa</given-names></name><xref ref-type="aff" rid="AF0030"><sup>30</sup></xref></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><xref ref-type="aff" rid="AF0005"><sup>5</sup></xref><xref ref-type="aff" rid="AF0011"><sup>11</sup></xref><xref ref-type="aff" rid="AF0012"><sup>12</sup></xref><xref ref-type="aff" rid="AF0013"><sup>13</sup></xref><xref ref-type="aff" rid="AF0031"><sup>31</sup></xref><xref ref-type="aff" rid="AF0032"><sup>32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name><xref ref-type="aff" rid="AF0031"><sup>31</sup></xref><xref ref-type="aff" rid="AF0032"><sup>32</sup></xref><xref ref-type="aff" rid="AF0033"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Geoffrey</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref><xref ref-type="aff" rid="AF0034"><sup>34</sup></xref></contrib><contrib contrib-type="author"><name><surname>McLaughlin</surname><given-names>John R.</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref><xref ref-type="aff" rid="AF0035"><sup>35</sup></xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Yafang</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Xiao</surname><given-names>Xiangjun</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fehringer</surname><given-names>Gord</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zong</surname><given-names>Xuchen</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Denroche</surname><given-names>Robert E.</given-names></name><xref ref-type="aff" rid="AF0036"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zuzarte</surname><given-names>Philip C.</given-names></name><xref ref-type="aff" rid="AF0036"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>McPherson</surname><given-names>John D.</given-names></name><xref ref-type="aff" rid="AF0036"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brennan</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hung</surname><given-names>Rayjean J.</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref><xref ref-type="corresp" rid="c1">*</xref></contrib><aff id="AF0001"><sup>1</sup><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3L9</addr-line>,<country>Canada</country>,</aff><aff id="AF0002"><sup>2</sup><institution>Division of Epidemiology</institution>,<institution>Dalla Lana School of Public Health</institution>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5T 3M7</addr-line>,<country>Canada</country>,</aff><aff id="AF0003"><sup>3</sup><institution>Department of Community and Family Medicine</institution>,<institution>Center for Genomic Medicine</institution>,<institution>Geisel School of Medicine</institution>,<institution>Dartmouth College</institution>,<addr-line>Lebanon</addr-line>,<addr-line>NH 03766</addr-line>,<country>USA</country>,</aff><aff id="AF0004"><sup>4</sup><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon, CEDEX 08, 69372</addr-line>,<country>France</country>,</aff><aff id="AF0005"><sup>5</sup><institution>Human Genetics Foundation (HuGeF), 10126</institution><addr-line>Torino</addr-line>,<country>Italy</country>,</aff><aff id="AF0006"><sup>6</sup><institution>Department of Epidemiology and Biostatistics</institution>,<institution>MRC-PHE Centre for Environment and Health</institution>,<institution>School of Public Health, Imperial College London</institution>,<addr-line>Norfolk Place</addr-line>,<addr-line>London W2 1PG</addr-line>,<country>UK</country>,</aff><aff id="AF0007"><sup>7</sup><institution>Department for Determinants of Chronic Diseases (DCD)</institution>,<institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>3721 MA Bilthoven</addr-line>,<country>The Netherlands</country>,</aff><aff id="AF0008"><sup>8</sup><institution>Department of Gastroenterology and Hepatology</institution>,<institution>University Medical Centre</institution>,<addr-line>3584 CX Utrecht</addr-line>,<country>The Netherlands</country>,</aff><aff id="AF0009"><sup>9</sup><institution>Department of Epidemiology and Biostatistics</institution>,<institution>The School of Public Health</institution>,<institution>Imperial College London</institution>,<addr-line>London SW7 2AZ</addr-line>,<country>UK</country>,</aff><aff id="AF0010"><sup>10</sup><institution>Department of Social and Preventive Medicine</institution>,<institution>Faculty of Medicine</institution>,<institution>University of Malaya</institution>,<addr-line>Kuala Lumpur 50603</addr-line>,<country>Malaysia</country>,</aff><aff id="AF0011"><sup>11</sup><institution>INSERM</institution>,<institution>Centre for Research in Epidemiology and Population Health (CESP), U1018, Lifestyle, Genes and Health: Integrative Trans-Generational Epidemiology</institution>,<addr-line>94805 Villejuif</addr-line>,<country>France</country>,</aff><aff id="AF0012"><sup>12</sup><institution>Université Paris Sud</institution>,<addr-line>UMRS 1018 94805, Villejuif</addr-line>,<country>France</country>,</aff><aff id="AF0013"><sup>13</sup><institution>Institut Gustave Roussy</institution><addr-line>F-94805, Villejuif</addr-line>,<country>France</country>,</aff><aff id="AF0014"><sup>14</sup><institution>Department of Radiation Sciences</institution>,<institution>Umeå University</institution>,<addr-line>Umeå SE-901 87</addr-line>,<country>Sweden</country>,</aff><aff id="AF0015"><sup>15</sup><institution>Public Health Directorate Asturias</institution>,<addr-line> CP 33006 Oviedo</addr-line>,<country>Spain</country>,</aff><aff id="AF0016"><sup>16</sup><institution>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori</institution>,<addr-line>20133 Milano</addr-line>,<country>Italy</country>,</aff><aff id="AF0017"><sup>17</sup><institution>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford</institution>,<addr-line>Oxford OX3 7LF</addr-line>,<country>UK</country>,</aff><aff id="AF0018"><sup>18</sup><institution>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway</institution>,<addr-line>9037 Tromsø</addr-line>,<country>Norway</country>,</aff><aff id="AF0019"><sup>19</sup><institution>Department of Research, Cancer Registry of Norway</institution>,<addr-line>0379 Oslo</addr-line>,<country>Norway</country>,</aff><aff id="AF0020"><sup>20</sup><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm SE-171 77</addr-line>,<country>Sweden</country>,</aff><aff id="AF0021"><sup>21</sup><institution>Genetic Epidemiology Group, Folkhälsan Research Center</institution>,<addr-line>Helsinki FI-00014</addr-line>,<country>Finland</country>,</aff><aff id="AF0022"><sup>22</sup><institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI 96813</addr-line>,<country>USA</country>,</aff><aff id="AF0023"><sup>23</sup><institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle</addr-line>,<addr-line>WA 98109</addr-line>,<country>USA</country>,</aff><aff id="AF0024"><sup>24</sup><institution>Departments of Environmental Health and Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country>,</aff><aff id="AF0025"><sup>25</sup><institution>Department of Medicine, Massachusetts General Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA 02114</addr-line>,<country>USA</country>,</aff><aff id="AF0026"><sup>26</sup><institution>Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School</institution>,<addr-line>Boston</addr-line>,<addr-line>MA 02115</addr-line>,<country>USA</country>,</aff><aff id="AF0027"><sup>27</sup><institution>Departments of Biostatistics and Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA 02115</addr-line>,<country>USA</country>,</aff><aff id="AF0028"><sup>28</sup><institution>Russian Cancer Research Center</institution>,<addr-line>Moscow 115478</addr-line>,<country>Russia</country>,</aff><aff id="AF0029"><sup>29</sup><institution>Roy Castle Lung Cancer Research Programme</institution>,<institution>University of Liverpool Cancer Research Centre Institute of Translational Medicine</institution>,<institution>University of Liverpool</institution>,<addr-line>Liverpool L69 3BX</addr-line>,<country>UK</country>,</aff><aff id="AF0030"><sup>30</sup><institution>Division of Cancer Epidemiology and Genetics</institution>,<institution>National Cancer Institute</institution>,<institution>National Institutes of Health</institution>,<institution>Department of Health and Human Services</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD 20892</addr-line>,<country>USA</country>,</aff><aff id="AF0031"><sup>31</sup><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Melbourne 3004</addr-line>,<country>Australia</country>,</aff><aff id="AF0032"><sup>32</sup><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution>,<institution>University of Melbourne</institution>,<country>Melbourne 3010, Australia</country>,</aff><aff id="AF0033"><sup>33</sup><institution>Department of Epidemiology and Preventive Medicine</institution>,<institution>Monash University</institution>,<addr-line>Melbourne 3004</addr-line>,<country>Australia</country>,</aff><aff id="AF0034"><sup>34</sup><institution>Ontario Cancer Institute</institution>,<institution>Princess Margaret Cancer Center</institution>,<addr-line>Toronto, Ontario M5G 0A3</addr-line>,<country>Canada</country>,</aff><aff id="AF0035"><sup>35</sup><institution>Public Health Ontario</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5G 1V2</addr-line>,<country>Canada</country>, and</aff><aff id="AF0036"><sup>36</sup><institution>Genome Technologies, Ontario Institute for Cancer Research</institution>,<addr-line>Toronto</addr-line>,<addr-line>Ontario M5G 0A3</addr-line>,<country>Canada</country></aff></contrib-group><author-notes><corresp id="c1">*To whom correspondence should be addressed. Tel: <phone>+1416 586 4750</phone>; Fax: <fax>+1416 586 8404</fax>; Email: <email>rayjean.hung@lunenfeld.ca</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>20</day><month>11</month><year>2015</year></pub-date><volume>37</volume><issue>1</issue><fpage>96</fpage><lpage>105</lpage><history><date date-type="received"><day>2</day><month>9</month><year>2015</year></date><date date-type="rev-recd"><day>2</day><month>11</month><year>2015</year></date><date date-type="accepted"><day>13</day><month>11</month><year>2015</year></date></history><permissions><copyright-statement>© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract abstract-type="precis"><title>Summary</title><p>Based on deep targeted sequencing and Axiom data in 10 lung cancer studies, our fine mapping analysis identified multiple novel lung cancer susceptibility variants in 5p15.33 region. It also demonstrated that telomere length is a key mechanism of these associations.</p></abstract><abstract><p>Chromosome 5p15.33 has been identified as a lung cancer susceptibility locus, however the underlying causal mechanisms were not fully elucidated. Previous fine-mapping studies of this locus have relied on imputation or investigated a small number of known, common variants. This study represents a significant advance over previous research by investigating a large number of novel, rare variants, as well as their underlying mechanisms through telomere length. Variants for this fine-mapping study were identified through a targeted deep sequencing (average depth of coverage greater than 4000×) of 576 individuals. Subsequently, 4652 SNPs, including 1108 novel SNPs, were genotyped in 5164 cases and 5716 controls of European ancestry. After adjusting for known risk loci, rs2736100 and rs401681, we identified a new, independent lung cancer susceptibility variant in <italic>LPCAT1</italic>: rs139852726 (OR = 0.46, <italic>P</italic> = 4.73×10<sup>–9</sup>), and three new adenocarcinoma risk variants in <italic>TERT</italic>: rs61748181 (OR = 0.53, <italic>P</italic> = 2.64×10<sup>–6</sup>), rs112290073 (OR = 1.85, <italic>P</italic> = 1.27×10<sup>–5</sup>), rs138895564 (OR = 2.16, <italic>P</italic> = 2.06×10<sup>–5</sup>; among young cases, OR = 3.77, <italic>P</italic> = 8.41×10<sup>–4</sup>). In addition, we found that rs139852726 (<italic>P</italic> = 1.44×10<sup>–3</sup>) was associated with telomere length in a sample of 922 healthy individuals. The gene-based SKAT-O analysis implicated <italic>TERT</italic> as the most relevant gene in the 5p15.33 region for adenocarcinoma (<italic>P</italic> = 7.84×10<sup>–7</sup>) and lung cancer (<italic>P</italic> = 2.37×10<sup>–5</sup>) risk. In this largest fine-mapping study to investigate a large number of rare and <italic>novel</italic> variants within 5p15.33, we identified novel lung and adenocarcinoma susceptibility loci with large effects and provided support for the role of telomere length as the potential underlying mechanism.</p></abstract><counts><page-count count="10"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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