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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Post-Discharge Mortality in Children with Severe Malnutrition and Pneumonia in Bangladesh</title><author><name sortKey="Chisti, Mohammod Jobayer" sort="Chisti, Mohammod Jobayer" uniqKey="Chisti M" first="Mohammod Jobayer" last="Chisti">Mohammod Jobayer Chisti</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><addr-line>Centre for International Child Health, The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children’s Hospital, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Graham, Stephen M" sort="Graham, Stephen M" uniqKey="Graham S" first="Stephen M." last="Graham">Stephen M. Graham</name><affiliation><nlm:aff id="aff2"><addr-line>Centre for International Child Health, The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children’s Hospital, Melbourne, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><addr-line>International Union Against Tuberculosis and Lung Disease, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Duke, Trevor" sort="Duke, Trevor" uniqKey="Duke T" first="Trevor" last="Duke">Trevor Duke</name><affiliation><nlm:aff id="aff2"><addr-line>Centre for International Child Health, The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children’s Hospital, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ahmed, Tahmeed" sort="Ahmed, Tahmeed" uniqKey="Ahmed T" first="Tahmeed" last="Ahmed">Tahmeed Ahmed</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Faruque, Abu Syed Golam" sort="Faruque, Abu Syed Golam" uniqKey="Faruque A" first="Abu Syed Golam" last="Faruque">Abu Syed Golam Faruque</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ashraf, Hasan" sort="Ashraf, Hasan" uniqKey="Ashraf H" first="Hasan" last="Ashraf">Hasan Ashraf</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bardhan, Pradip Kumar" sort="Bardhan, Pradip Kumar" uniqKey="Bardhan P" first="Pradip Kumar" last="Bardhan">Pradip Kumar Bardhan</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shahid, Abu S M S B" sort="Shahid, Abu S M S B" uniqKey="Shahid A" first="Abu S. M. S. B." last="Shahid">Abu S. M. S. B. Shahid</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shahunja, K M" sort="Shahunja, K M" uniqKey="Shahunja K" first="K. M." last="Shahunja">K. M. Shahunja</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Salam, Mohammed Abdus" sort="Salam, Mohammed Abdus" uniqKey="Salam M" first="Mohammed Abdus" last="Salam">Mohammed Abdus Salam</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25225798</idno><idno type="pmc">4167196</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167196</idno><idno type="RBID">PMC:4167196</idno><idno type="doi">10.1371/journal.pone.0107663</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000359</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000359</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Post-Discharge Mortality in Children with Severe Malnutrition and Pneumonia in Bangladesh</title><author><name sortKey="Chisti, Mohammod Jobayer" sort="Chisti, Mohammod Jobayer" uniqKey="Chisti M" first="Mohammod Jobayer" last="Chisti">Mohammod Jobayer Chisti</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><addr-line>Centre for International Child Health, The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children’s Hospital, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Graham, Stephen M" sort="Graham, Stephen M" uniqKey="Graham S" first="Stephen M." last="Graham">Stephen M. Graham</name><affiliation><nlm:aff id="aff2"><addr-line>Centre for International Child Health, The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children’s Hospital, Melbourne, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><addr-line>International Union Against Tuberculosis and Lung Disease, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Duke, Trevor" sort="Duke, Trevor" uniqKey="Duke T" first="Trevor" last="Duke">Trevor Duke</name><affiliation><nlm:aff id="aff2"><addr-line>Centre for International Child Health, The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children’s Hospital, Melbourne, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ahmed, Tahmeed" sort="Ahmed, Tahmeed" uniqKey="Ahmed T" first="Tahmeed" last="Ahmed">Tahmeed Ahmed</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Faruque, Abu Syed Golam" sort="Faruque, Abu Syed Golam" uniqKey="Faruque A" first="Abu Syed Golam" last="Faruque">Abu Syed Golam Faruque</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ashraf, Hasan" sort="Ashraf, Hasan" uniqKey="Ashraf H" first="Hasan" last="Ashraf">Hasan Ashraf</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bardhan, Pradip Kumar" sort="Bardhan, Pradip Kumar" uniqKey="Bardhan P" first="Pradip Kumar" last="Bardhan">Pradip Kumar Bardhan</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shahid, Abu S M S B" sort="Shahid, Abu S M S B" uniqKey="Shahid A" first="Abu S. M. S. B." last="Shahid">Abu S. M. S. B. Shahid</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shahunja, K M" sort="Shahunja, K M" uniqKey="Shahunja K" first="K. M." last="Shahunja">K. M. Shahunja</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Salam, Mohammed Abdus" sort="Salam, Mohammed Abdus" uniqKey="Salam M" first="Mohammed Abdus" last="Salam">Mohammed Abdus Salam</name><affiliation><nlm:aff id="aff1"><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Post-discharge mortality among children with severe illness in resource-limited settings is under-recognized and there are limited data. We evaluated post-discharge mortality in a recently reported cohort of children with severe malnutrition and pneumonia, and identified characteristics associated with an increased risk of death.</p></sec><sec><title>Methods</title><p>Young children (<5 years of age) with severe malnutrition (WHO criteria) and radiographic pneumonia on admission to Dhaka Hospital of icddr,b over a 15-month period were managed according to standard protocols. Those discharged were followed-up and survival status at 12 weeks post-discharge was determined. Verbal autopsy was requested from families of those that died.</p></sec><sec><title>Results</title><p>Of 405 children hospitalized with severe malnutrition and pneumonia, 369 (median age, 10 months) were discharged alive with a follow-up plan. Of these, 32 (8.7%) died in the community within 3 months of discharge: median 22 (IQR 9–35) days from discharge to death. Most deaths were reportedly associated with acute onset of new respiratory or gastrointestinal symptoms. Those that died following discharge were significantly younger (median 6 [IQR 3,12] months) and more severely malnourished, on admission and on discharge, than those that survived. Bivariate analysis found that severe wasting on admission (OR 3.64, 95% CI 1.66–7.97) and age <12 months (OR 2.54, 95% CI 1.1–8.8) were significantly associated with post-discharge death. Of those that died in the community, none had attended a scheduled follow-up and care-seeking from a traditional healer was more common (p<0.001) compared to those who survived.</p></sec><sec><title>Conclusion and Significance</title><p>Post-discharge mortality was common in Bangladeshi children following inpatient care for severe malnutrition and pneumonia. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25225798</article-id><article-id pub-id-type="pmc">4167196</article-id><article-id pub-id-type="publisher-id">PONE-D-14-19394</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0107663</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology and Life Sciences</subject><subj-group><subject>Nutrition</subject><subj-group><subject>Malnutrition</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine and Health Sciences</subject><subj-group><subject>Clinical Medicine</subject></subj-group><subj-group><subject>Infectious Diseases</subject></subj-group><subj-group><subject>Pediatrics</subject><subj-group><subject>Child Health</subject><subject>Pediatric Infections</subject><subject>Pediatric Pulmonology</subject></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Post-Discharge Mortality in Children with Severe Malnutrition and Pneumonia in Bangladesh</article-title><alt-title alt-title-type="running-head">Post-Discharge Mortality in Severely Malnourished Pneumonia Children</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chisti</surname><given-names>Mohammod Jobayer</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Graham</surname><given-names>Stephen M.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Duke</surname><given-names>Trevor</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ahmed</surname><given-names>Tahmeed</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Faruque</surname><given-names>Abu Syed Golam</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ashraf</surname><given-names>Hasan</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bardhan</surname><given-names>Pradip Kumar</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shahid</surname><given-names>Abu S. M. S. B.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shahunja</surname><given-names>K. M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Salam</surname><given-names>Mohammed Abdus</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Centre for International Child Health, The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children’s Hospital, Melbourne, Australia</addr-line></aff><aff id="aff3"><label>3</label><addr-line>International Union Against Tuberculosis and Lung Disease, Paris, France</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Esposito</surname><given-names>Susanna</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Italy</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>steve.graham@rch.org.au</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: MJC SMG TD TA ASGF HA PKB KMS ASMSBS MAS. Performed the experiments: MJC SMG TD TA KMS ASMSBS MAS. Analyzed the data: MJC SMG TD TA ASGF HA PKB KMS ASMSBS MAS. Contributed reagents/materials/analysis tools: KMS ASMSBS. Contributed to the writing of the manuscript: MJC SMG TD TA ASGF HA PKB KMS ASMSBS MAS. Designed the software used in analysis: MJC KMS. Defended institutional review board (Research Review Committee and Ethical Review Committee): MJC MAS.</p></fn></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>16</day><month>9</month><year>2014</year></pub-date><volume>9</volume><issue>9</issue><elocation-id>e107663</elocation-id><history><date date-type="received"><day>30</day><month>4</month><year>2014</year></date><date date-type="accepted"><day>12</day><month>8</month><year>2014</year></date></history><permissions><copyright-year>2014</copyright-year><copyright-holder>Chisti et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><sec><title>Background</title><p>Post-discharge mortality among children with severe illness in resource-limited settings is under-recognized and there are limited data. We evaluated post-discharge mortality in a recently reported cohort of children with severe malnutrition and pneumonia, and identified characteristics associated with an increased risk of death.</p></sec><sec><title>Methods</title><p>Young children (<5 years of age) with severe malnutrition (WHO criteria) and radiographic pneumonia on admission to Dhaka Hospital of icddr,b over a 15-month period were managed according to standard protocols. Those discharged were followed-up and survival status at 12 weeks post-discharge was determined. Verbal autopsy was requested from families of those that died.</p></sec><sec><title>Results</title><p>Of 405 children hospitalized with severe malnutrition and pneumonia, 369 (median age, 10 months) were discharged alive with a follow-up plan. Of these, 32 (8.7%) died in the community within 3 months of discharge: median 22 (IQR 9–35) days from discharge to death. Most deaths were reportedly associated with acute onset of new respiratory or gastrointestinal symptoms. Those that died following discharge were significantly younger (median 6 [IQR 3,12] months) and more severely malnourished, on admission and on discharge, than those that survived. Bivariate analysis found that severe wasting on admission (OR 3.64, 95% CI 1.66–7.97) and age <12 months (OR 2.54, 95% CI 1.1–8.8) were significantly associated with post-discharge death. Of those that died in the community, none had attended a scheduled follow-up and care-seeking from a traditional healer was more common (p<0.001) compared to those who survived.</p></sec><sec><title>Conclusion and Significance</title><p>Post-discharge mortality was common in Bangladeshi children following inpatient care for severe malnutrition and pneumonia. The underlying contributing factors require a better understanding to inform the potential of interventions that could improve survival.</p></sec></abstract><funding-group><funding-statement>This research study was funded by the Dhaka Hospital of International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B; grant no Gr-00233) and its donors, which provide unrestricted support to ICDDR, B for its operations and research. Current donors providing unrestricted support include: Australian Agency for International Development, Government of the People’s Republic of Bangladesh, Canadian International Development Agency, Swedish International Development Cooperation Agency, and the Department for International Development, United Kingdom. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="7"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>The authors confirm that, for approved reasons, some access restrictions apply to the data underlying the findings. Data are available from the icddr,b Institutional Data Access for researchers who meet the criteria for access to confidential data.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>The authors confirm that, for approved reasons, some access restrictions apply to the data underlying the findings. Data are available from the icddr,b Institutional Data Access for researchers who meet the criteria for access to confidential data.</p></notes></front><body><sec id="s1"><title>Introduction</title><p>Malnutrition is recognized as a major underlying risk factor for death in children with common infections causing global child mortality such as pneumonia, diarrhea and sepsis <xref rid="pone.0107663-Walker1" ref-type="bibr">[1]</xref>, <xref rid="pone.0107663-Bejon1" ref-type="bibr">[2]</xref>. Furthermore, these infectious diseases further increase the high risk of mortality that is reported in children with severe malnutrition managed as inpatients in resource-poor settings of Africa and Asia <xref rid="pone.0107663-Roy1" ref-type="bibr">[3]</xref>–<xref rid="pone.0107663-Brewster1" ref-type="bibr">[7]</xref>. Malnutrition is also a consistent risk factor for post-discharge death in common childhood illnesses in high-mortality settings, including studies from Bangladesh of children hospitalized with diarrhea <xref rid="pone.0107663-Wiens1" ref-type="bibr">[8]</xref>–<xref rid="pone.0107663-Islam1" ref-type="bibr">[10]</xref>. However, there are limited data available from studies that have followed severely malnourished children following discharge from inpatient facilities. Currently, these data are all from settings in sub-Saharan Africa <xref rid="pone.0107663-Kerac1" ref-type="bibr">[5]</xref>, <xref rid="pone.0107663-Reneman1" ref-type="bibr">[11]</xref>, <xref rid="pone.0107663-Hennart1" ref-type="bibr">[12]</xref> and previous studies have not reported post-discharge death in children with severe malnutrition and pneumonia.</p><p>Bangladesh has high rates of childhood malnutrition. A UNICEF report published in 2013 reported that 36% of Bangladeshi children had moderate or severe wasting and that 41% had moderate or severe stunting in the period 2007 to 2011 <xref rid="pone.0107663-Marais1" ref-type="bibr">[13]</xref>. We recently undertook a study to determine bacterial and mycobacterial aetiology of pneumonia in children with severe malnutrition admitted to the Dhaka Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr’b) in Dhaka, Bangladesh <xref rid="pone.0107663-Chisti2" ref-type="bibr">[14]</xref>. The aim of this analysis was to report inpatient and early post-discharge mortality in this same cohort of children with severe malnutrition and radiological pneumonia, and to identify characteristics associated with an increased risk of death following discharge.</p></sec><sec sec-type="materials|methods" id="s2"><title>Materials and Methods</title><sec id="s2a"><title>Ethics statement</title><p>The study (protocol number: PR-10067) was approved by the Research Review Committee (RRC) and the Ethical Review Committee (ERC) of icddr,b. Written informed consent was obtained from parents or attending guardians of all the participating children.</p></sec><sec id="s2b"><title>Study setting and design</title><p>This was a prospective study cohort study that included young children (0–59 months of age) with severe malnutrition, respiratory symptoms and radiological pneumonia as previously described in detail <xref rid="pone.0107663-Chisti2" ref-type="bibr">[14]</xref>. In brief, eligible children admitted to the Dhaka Hospital of icddr,b between April 2011 and June 2012 were enrolled following informed consent. Demographic, contact details (phone and address) and clinical data were collected prospectively on standardized data collection proforma. Radiographs were interpreted independently by a radiologist and a study pediatrician (MJC). Radiological pneumonia was defined as the presence of end-point consolidation or other (non-end-point) infiltrate in lungs according to the WHO radiological classification of pneumonia <xref rid="pone.0107663-Cherian1" ref-type="bibr">[15]</xref>. Severe malnutrition was defined in children as severe wasting [z score for weight for height <−3 of the median of the WHO anthropometry] or severe underweight [z score for weight for age <−4 of the median of the WHO anthropometry], or the presence of nutritional edema. Clinical management was according to standardized guidelines with regards to antibiotics, detection and management of hypoxemia and hypoglycemia, fluid management and nutritional support <xref rid="pone.0107663-Chisti2" ref-type="bibr">[14]</xref>, <xref rid="pone.0107663-World1" ref-type="bibr">[16]</xref>.</p><p>Once children were considered to have shown clinical improvement for pneumonia and stabilized, they were transferred to the nutritional rehabilitation unit (NRU) for ongoing care before hospital discharge and were managed according to standard guidelines <xref rid="pone.0107663-Ahmed1" ref-type="bibr">[6]</xref>. During the NRU stay, mothers are taught to prepare high energy food from locally available and culturally acceptable foodstuffs, and advised to provide such food once discharged. The decision to discharge is normally based on the criteria used by the NRU staff, i.e. weight gain of >15% of admission weight (after resolution of edema in those with nutritional edema). However, many children are discharged before these criteria are reached and are discharged “on risk bond”. The main reason is request for early discharge by the mother because of pressure from the child’s father or grandparents for the mother (and child) to return home once the child is thought to be no longer acutely ill. No additional nutritional supplements such as Ready-to-Use Therapeutic Food (RUTF) are provided on discharge.</p><p>The primary outcome for analysis was survival status at 3 months post-discharge. Secondary outcomes included the type and duration of new symptoms associated with those that died as reported by verbal autopsy and the proportion of those discharged that were lost-to-follow-up.</p></sec><sec id="s2c"><title>Follow-up procedure</title><p>All of the enrolled children that survived hospitalization were requested to attend follow-up for 3 months post-discharge as per routine follow-up by NRU. This included children that were discharged either as left against medical advice or those discharged “on risk bond” from the NRU. Follow-up was planned weekly for the first 2 weeks following discharge and monthly thereafter until the following criteria are met: weight for length ≥−1 z score and/or weight for age ≥−2 z score. Routine follow-up included measurement of nutritional parameters and vital signs, as well as assessment for and management of any intercurrent illness. Neither additional nutritional supplements such as RUTF nor support for transport costs were provided at follow-up visits.</p><p>There were 86 children discharged that had been diagnosed with tuberculosis, of which 27 were microbiologically confirmed <xref rid="pone.0107663-Chisti2" ref-type="bibr">[14]</xref>. It was planned that all children discharged receiving anti-tuberculosis treatment were followed until completion of the course i.e. for 6 months.</p><p>For this study, all care-givers were provided instructions verbally in local language regarding follow-up. They were requested to return to the hospital at 12 weeks following discharge but advised that if their children developed any symptoms or signs of illness at any time prior to this, then they should either return to the hospital or consult with a study physician by mobile phone at any time. The phone numbers of the study physicians were provided during discharge and all caregivers had access to mobile phones. No funding was provided for potential phone call costs. If any of the caregivers did not attend the 12-week post-discharge follow-up, the study staff attempted to contact them via mobile phone. If any of the care-givers could not be contacted by mobile phone or still did not attend the follow-up after contact by mobile phone, then research assistants visited their home to ensure follow-up. Study participants were defined as “lost to follow-up” if research assistants visited the given address on at least two separate occasions and failed to identify them.</p><p>Verbal autopsy was requested when possible for those children that were identified as having died during the follow-up period. Verbal autopsy procedure followed the WHO standard questionnaire <xref rid="pone.0107663-World2" ref-type="bibr">[17]</xref>. Information obtained included the presence and duration of symptoms prior to death as well as treatment sought. Interviews were undertaken by the study physicians at icddr’b for the majority that were willing to attend, otherwise the interview was performed by mobile phone (n = 4).</p></sec><sec id="s2d"><title>Data analysis</title><p>All data were entered into SPSS for Windows (version 15.0; SPSS Inc, Chicago) and Epi-Info (version 6.0, USD, Stone Mountain, GA). Follow-up was planned prospectively and ethically approved. However, the primary objective of this study that determined sample size was to determine prevalence of sepsis and tuberculosis, as previously reported <xref rid="pone.0107663-Chisti2" ref-type="bibr">[14]</xref>. We used this sample of patients to determine characteristics associated with post-discharge death. Differences in proportions were compared by the Chi-square test. Differences of means were compared by Student’s t-test for normally distributed data and Mann-Whitney test was used for comparison of data that were not normally distributed. Strength of association was determined by calculating odds ratio (OR) and their 95% confidence intervals (CIs). Two pragmatic categorical variables (age and severity of malnutrition on admission) were identified based on previous literature <xref rid="pone.0107663-Wiens1" ref-type="bibr">[8]</xref> and univariate analysis of the dataset for bivariate analysis using logistic regression.</p></sec></sec><sec id="s3"><title>Results</title><p>A total of 405 children with severe malnutrition and radiological pneumonia were enrolled at admission and have been described previously <xref rid="pone.0107663-Chisti2" ref-type="bibr">[14]</xref>. Of these, 35 (8.6%) died as inpatients and 1 patient absconded without follow-up arranged. <xref ref-type="fig" rid="pone-0107663-g001">Figure 1</xref> illustrates a flowchart from admission to follow-up showing that 369 children were discharged with a follow-up plan, including 29 that left against medical advice prior to planned discharge. The median (IQR) age in months of these 369 children was 10 (5, 18) months. The median (IQR) duration of inpatient care before transfer to the NRU for the 340 survivors that were discharged was 6 (4, 10) days, and was of similar duration for the 29 that left against medical advice - 8 (4, 9) days. Of those transferred to the NRU, the majority were discharged early “on risk bond”. Only 43 (13%) remained at the NRU until they reached the standard discharge criteria and median (IQR) duration of hospital stay for these was 18 (12,22) days which compared to only 5 (4,8) days for the remaining 297 that were discharged early.</p><fig id="pone-0107663-g001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0107663.g001</object-id><label>Figure 1</label><caption><title>Flowchart of study subjects from admission until final follow-up.</title></caption><graphic xlink:href="pone.0107663.g001"></graphic></fig><p>At 3 months post-discharge, 32 (8.7%) children were known to have died in the community. None of those that died attended any follow-up visit. A further 54 (15%) of the 369 children discharged were lost-to follow-up with no knowledge of outcomes at 3 months post-discharge – <xref ref-type="fig" rid="pone-0107663-g001">Figure 1</xref>. <xref ref-type="table" rid="pone-0107663-t001">Table 1</xref> lists and compares patient characteristics on admission that were associated with known death following discharge and compared to those known to have survived. The features of the 54 children that were lost-to-follow-up but with unknown outcomes are also listed.</p><table-wrap id="pone-0107663-t001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0107663.t001</object-id><label>Table 1</label><caption><title>Characteristics of severely malnourished children (<5 years) with pneumonia who died within 3 months following discharge compared to those known to have survived evaluating known risk factors for outcome such as age, severity of malnutrition and severity of pneumonia.</title></caption><alternatives><graphic id="pone-0107663-t001-1" xlink:href="pone.0107663.t001"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1">Characteristics</td><td align="left" rowspan="1" colspan="1">Deaths(N = 32) N (%)</td><td align="left" rowspan="1" colspan="1">Survivors(N = 283) N (%)</td><td align="left" rowspan="1" colspan="1">LTFU(n = 54) N (%)</td><td align="left" rowspan="1" colspan="1">UnadjustedOR (95% CI)</td></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><bold><italic>On admission</italic></bold></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Age in months: median (IQR)<xref ref-type="table-fn" rid="nt101">*</xref></td><td align="left" rowspan="1" colspan="1">6 (3,12)</td><td align="left" rowspan="1" colspan="1">10 (5, 18)</td><td align="left" rowspan="1" colspan="1">12 (5, 21)</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Age less than 12 months</td><td align="left" rowspan="1" colspan="1">23 (72)</td><td align="left" rowspan="1" colspan="1">157 (56)</td><td align="left" rowspan="1" colspan="1">27 (50)</td><td align="left" rowspan="1" colspan="1">2.05 (0.9–4.9)</td></tr><tr><td align="left" rowspan="1" colspan="1">Male</td><td align="left" rowspan="1" colspan="1">15 (47)</td><td align="left" rowspan="1" colspan="1">160 (57)</td><td align="left" rowspan="1" colspan="1">31 (57)</td><td align="left" rowspan="1" colspan="1">0.68 (0.3–1.5)</td></tr><tr><td align="left" rowspan="1" colspan="1">Live outside Dhaka district</td><td align="left" rowspan="1" colspan="1">10 (31)</td><td align="left" rowspan="1" colspan="1">60 (21)</td><td align="left" rowspan="1" colspan="1">9 (17)</td><td align="left" rowspan="1" colspan="1">1.69 (0.7–4.0)</td></tr><tr><td align="left" rowspan="1" colspan="1">Poor socio-economiccondition - income <125USD per month</td><td align="left" rowspan="1" colspan="1">25 (78)</td><td align="left" rowspan="1" colspan="1">235 (83)</td><td align="left" rowspan="1" colspan="1">51 (94)</td><td align="left" rowspan="1" colspan="1">0.73 (0.3–2.0)</td></tr><tr><td align="left" rowspan="1" colspan="1">History of previouspneumonia prior to present episode<xref ref-type="table-fn" rid="nt101">*</xref></td><td align="left" rowspan="1" colspan="1">6 (19)</td><td align="left" rowspan="1" colspan="1">18 (6)</td><td align="left" rowspan="1" colspan="1">4 (7)</td><td align="left" rowspan="1" colspan="1">3.4 (1.1–10.2)</td></tr><tr><td align="left" rowspan="1" colspan="1">Severe wasting<xref ref-type="table-fn" rid="nt101">*</xref>(z score <−4 weight-for-height/length)</td><td align="left" rowspan="1" colspan="1">20 (63)</td><td align="left" rowspan="1" colspan="1">107 (38)</td><td align="left" rowspan="1" colspan="1">23 (43)</td><td align="left" rowspan="1" colspan="1">2.74 (1.2–6.2)</td></tr><tr><td align="left" rowspan="1" colspan="1">Severe underweight<xref ref-type="table-fn" rid="nt101">*</xref>(z score <−5 weight-for-age)</td><td align="left" rowspan="1" colspan="1">22 (69)</td><td align="left" rowspan="1" colspan="1">124 (44)</td><td align="left" rowspan="1" colspan="1">22 (41)</td><td align="left" rowspan="1" colspan="1">2.82 (1.2–6.7)</td></tr><tr><td align="left" rowspan="1" colspan="1">Nutritional edema</td><td align="left" rowspan="1" colspan="1">3 (9)</td><td align="left" rowspan="1" colspan="1">12 (4)</td><td align="left" rowspan="1" colspan="1">1 (2)</td><td align="left" rowspan="1" colspan="1">2.34 (0.5–9.6)</td></tr><tr><td align="left" rowspan="1" colspan="1">Lower chest wall in-drawing</td><td align="left" rowspan="1" colspan="1">12 (38)</td><td align="left" rowspan="1" colspan="1">116 (41)</td><td align="left" rowspan="1" colspan="1">15 (28)</td><td align="left" rowspan="1" colspan="1">0.86 (0.4–1.9)</td></tr><tr><td align="left" rowspan="1" colspan="1">Hypoxemia(arterial oxygen saturation <90% in room air)</td><td align="left" rowspan="1" colspan="1">3 (9)</td><td align="left" rowspan="1" colspan="1">22 (8)</td><td align="left" rowspan="1" colspan="1">2 (4)</td><td align="left" rowspan="1" colspan="1">1.23 (0.3–4.7)</td></tr><tr><td align="left" rowspan="1" colspan="1">Confirmed TB</td><td align="left" rowspan="1" colspan="1">3 (9)</td><td align="left" rowspan="1" colspan="1">16 (6)</td><td align="left" rowspan="1" colspan="1">8 (15)</td><td align="left" rowspan="1" colspan="1">1.74 (0.4–6.9)</td></tr><tr><td align="left" rowspan="1" colspan="1">Clinical TB – not confirmed</td><td align="left" rowspan="1" colspan="1">1 (3)</td><td align="left" rowspan="1" colspan="1">50 (18)</td><td align="left" rowspan="1" colspan="1">8 (15)</td><td align="left" rowspan="1" colspan="1">0.15 (0.01–1.1)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold><italic>On discharge</italic></bold></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Duration of hospitalstay in days: median (IQR)</td><td align="left" rowspan="1" colspan="1">7 (4, 11)</td><td align="left" rowspan="1" colspan="1">6 (4, 10)</td><td align="left" rowspan="1" colspan="1">6 (3, 9)</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Left against medical advice<xref ref-type="table-fn" rid="nt101">*</xref></td><td align="left" rowspan="1" colspan="1">8 (25)</td><td align="left" rowspan="1" colspan="1">21 (7)</td><td align="left" rowspan="1" colspan="1">0 (0)</td><td align="left" rowspan="1" colspan="1">4.16 (1.5–11.3)</td></tr><tr><td align="left" rowspan="1" colspan="1">Severe wasting<xref ref-type="table-fn" rid="nt101">*</xref>(z score <−4 weight-for-height/length)</td><td align="left" rowspan="1" colspan="1">14 (45)</td><td align="left" rowspan="1" colspan="1">55 (20)</td><td align="left" rowspan="1" colspan="1">15 (28)</td><td align="left" rowspan="1" colspan="1">3.40 (1.5–7.8)</td></tr><tr><td align="left" rowspan="1" colspan="1">Severe underweight<xref ref-type="table-fn" rid="nt101">*</xref>(z score <−5 weight-for-age)</td><td align="left" rowspan="1" colspan="1">18 (56)</td><td align="left" rowspan="1" colspan="1">84 (30)</td><td align="left" rowspan="1" colspan="1">18 (33)</td><td align="left" rowspan="1" colspan="1">3.05 (1.4–6.8)</td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt101"><label></label><p>*P value significant (<0.05) for comparison of deaths vs. survivors.</p></fn><fn id="nt102"><label></label><p>LTFU = lost-to follow-up; OR = Odds ratio; CI = Confidence interval; IQR = Interquartile range.</p></fn></table-wrap-foot></table-wrap><p>Compared to survivors, those that died post-discharge were younger [median (IQR): 6.5 (3, 12) months], more severely malnourished on admission and more commonly had a previous admission for pneumonia (<xref ref-type="table" rid="pone-0107663-t001">Table 1</xref>). On bivariate analysis, severe wasting on admission (OR 3.64 [95% CI 1.66–7.97], p = 0.001) and age <12 months (OR 2.54 [95% CI 1.1–8.8], p = 0.03) were significantly associated with post-discharge death. Those that died post-discharge were also significantly more malnourished at discharge than those that survived. There was no significant difference in changes to nutritional parameters (by z score) from admission to discharge between those that died and survivors. Post-discharge death was more common in those that were discharged early “on risk bond” from the NRU than those that were discharged once NRU criteria were met with only 1 death in the latter group (P = 0.25).</p><p>The median time gap between discharge and death was 22 (9, 35) days. Most deaths occurred within 1 month following discharge and 34% before the first scheduled follow-up visit (<xref ref-type="table" rid="pone-0107663-t002">Table 2</xref>). Characteristics of these early post-discharge deaths such as age and nutritional status were similar to those that died later than two weeks post-discharge (data not shown). There were 86 children discharged receiving anti-tuberculosis treatment <xref rid="pone.0107663-Chisti2" ref-type="bibr">[14]</xref>. Four of these died within the 3 month follow-up period of which 3 had microbiologically confirmed tuberculosis and the other had clinically diagnosed tuberculosis that was not confirmed microbiologically. Death was recorded more significantly commonly in those that left against medical advice (8 or 28% died of 29) compared to those that were discharged according to usual protocol (24 or 7% of 340) – odds ratio 23.6 (95% CI 9.4–59); P<0.0001.</p><table-wrap id="pone-0107663-t002" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0107663.t002</object-id><label>Table 2</label><caption><title>Characteristics of post-discharge deaths: timing of death and verbal autopsy findings.</title></caption><alternatives><graphic id="pone-0107663-t002-2" xlink:href="pone.0107663.t002"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td colspan="3" align="left" rowspan="1"><italic>Time of death after discharge n = 32</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Timing of death post-discharge</td><td align="left" rowspan="1" colspan="1">N (%)</td><td align="left" rowspan="1" colspan="1">Cumulative</td></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Death during weeks 1–2</td><td align="left" rowspan="1" colspan="1">11 (34%)</td><td align="left" rowspan="1" colspan="1">34%</td></tr><tr><td align="left" rowspan="1" colspan="1">Death during weeks 3–4</td><td align="left" rowspan="1" colspan="1">8 (25%)</td><td align="left" rowspan="1" colspan="1">59%</td></tr><tr><td align="left" rowspan="1" colspan="1">Death during month 2</td><td align="left" rowspan="1" colspan="1">9 (28%)</td><td align="left" rowspan="1" colspan="1">87%</td></tr><tr><td align="left" rowspan="1" colspan="1">Death during month 3</td><td align="left" rowspan="1" colspan="1">4 (13%)</td><td align="left" rowspan="1" colspan="1">100%</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold><italic>Caregiver providing verbal autopsy n = 32</italic></bold></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Mother</td><td align="left" rowspan="1" colspan="1">18 (56%)</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Father</td><td align="left" rowspan="1" colspan="1">7 (22%)</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">None available<xref ref-type="table-fn" rid="nt103">*</xref></td><td align="left" rowspan="1" colspan="1">7 (22%)</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold><italic>Verbal autopsy findings n = 25</italic></bold></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Place of death</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Home</td><td align="left" rowspan="1" colspan="1">20 (80%)</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">At other hospital (local)</td><td align="left" rowspan="1" colspan="1">4 (16%)</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">On the way to hospital</td><td align="left" rowspan="1" colspan="1">1 (4%)</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Reported symptoms (new onset)</bold></td><td align="left" rowspan="1" colspan="1"><bold>N (%)</bold></td><td align="left" rowspan="1" colspan="1"><bold>Duration in days (median, IQR)</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Cough</td><td align="left" rowspan="1" colspan="1">21 (84%)</td><td align="left" rowspan="1" colspan="1">5 (3, 7)</td></tr><tr><td align="left" rowspan="1" colspan="1">Difficulty breathing</td><td align="left" rowspan="1" colspan="1">18 (72%)</td><td align="left" rowspan="1" colspan="1">2.5 (2, 4)</td></tr><tr><td align="left" rowspan="1" colspan="1">Fever</td><td align="left" rowspan="1" colspan="1">14 (56%)</td><td align="left" rowspan="1" colspan="1">3.5 (2, 5)</td></tr><tr><td align="left" rowspan="1" colspan="1">Watery diarrhea</td><td align="left" rowspan="1" colspan="1">14 (56%)</td><td align="left" rowspan="1" colspan="1">3 (1.8, 4)</td></tr><tr><td align="left" rowspan="1" colspan="1">Vomiting</td><td align="left" rowspan="1" colspan="1">11 (44%)</td><td align="left" rowspan="1" colspan="1">2 (1, 3)</td></tr><tr><td align="left" rowspan="1" colspan="1">Abdominal distension</td><td align="left" rowspan="1" colspan="1">8 (32%)</td><td align="left" rowspan="1" colspan="1">2 (1.3, 2)</td></tr><tr><td align="left" rowspan="1" colspan="1">Poor feeding</td><td align="left" rowspan="1" colspan="1">12 (48%)</td><td align="left" rowspan="1" colspan="1">3 (2, 5)</td></tr><tr><td align="left" rowspan="1" colspan="1">White patches on tongue (oral thrush)</td><td align="left" rowspan="1" colspan="1">4 (16%)</td><td align="left" rowspan="1" colspan="1">5 (3.5, 6.5)</td></tr><tr><td align="left" rowspan="1" colspan="1">Treatment</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">History of taking treatment during illness</td><td align="left" rowspan="1" colspan="1">13 (52%)</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Any documentation of treatment</td><td align="left" rowspan="1" colspan="1">7 (28%)</td><td align="left" rowspan="1" colspan="1"></td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt103"><label></label><p>*For the 7 deaths without verbal autopsy information, deaths were confirmed by relatives or neighbors when given home address was visited, but the family had moved house and were unable to be contacted or declined further contact with the study team.</p></fn></table-wrap-foot></table-wrap><p>Clinical findings from those that had verbal autopsy responses available are shown in <xref ref-type="table" rid="pone-0107663-t002">Table 2</xref>. These findings suggest that deaths usually followed acute lower respiratory tract infections or acute gastroenteritis. Of the 32 deaths, 14 were receiving treatment from a traditional healer compared to only 1 of the 283 survivors at 12 weeks’ post-discharge: unadjusted odds ratio 56.2 (95% CI 15.1–229); P<0.001. Although all the care givers had the access to mobile phone (their own or their relatives), none (0%) of the care givers among the deaths had consulted with study physicians using their mobile phone whereas 115 (41%) of 283 survivors consulted the study physicians by phone (p<0.001).</p></sec><sec id="s4"><title>Discussion</title><p>This study provides original data reporting a high mortality within 3 months of discharge of Bangladeshi children following hospitalization with severe malnutrition and pneumonia. The reported post-discharge mortality of 8.7% is similar to the inpatient mortality for this group, and most of the post-discharge deaths occurred within 1 month following discharge. Previous studies from urban and rural Bangladesh have reported similar or higher post-discharge mortality in children hospitalized with diarrhea, with severe malnutrition recognized as a risk factor for death <xref rid="pone.0107663-Roy2" ref-type="bibr">[9]</xref>, <xref rid="pone.0107663-Islam1" ref-type="bibr">[10]</xref>. Pneumonia is known to be a common co-morbidity in children with severe malnutrition that is associated with inpatient death <xref rid="pone.0107663-Chisti1" ref-type="bibr">[4]</xref>. We provide original data of post-discharge outcomes in this group.</p><p>While studies directly reporting post-discharge mortality of children with severe malnutrition are surprisingly limited <xref rid="pone.0107663-Islam1" ref-type="bibr">[10]</xref>–<xref rid="pone.0107663-Hennart1" ref-type="bibr">[12]</xref>, there are data from recent intervention studies in populations of children with severe malnutrition that do follow such children once discharged to the community for home-based management. A recent study that included 393 HIV-uninfected Malawian children with severe malnutrition and with a very low rate of defaulting reported 44 (11%) deaths within 3 months <xref rid="pone.0107663-Kerac1" ref-type="bibr">[5]</xref>. In another study in Malawi evaluating home-based RUTF, the proportion of those with WHO-defined severe malnutrition that died among the non-intervention group was 6.2% <xref rid="pone.0107663-Ciliberto1" ref-type="bibr">[18]</xref>. However, that study population was somewhat different to the one reported here in that it only included children older than 10 months and excluded those who had evidence of systemic infection or severe edema at enrolment.</p><p>Admission characteristics that were associated with post-discharge mortality included young age and severity of malnutrition, consistent with previous observations of post-discharge mortality in children <xref rid="pone.0107663-Wiens1" ref-type="bibr">[8]</xref>, <xref rid="pone.0107663-Roy2" ref-type="bibr">[9]</xref>, <xref rid="pone.0107663-Veirum1" ref-type="bibr">[19]</xref>. Previous hospitalization for pneumonia and having congenital heart disease were also significantly associated with mortality but the numbers for each of these groups were small. Severity of malnutrition on discharge was associated with poor outcome as was leaving against medical advice. The symptoms present prior to death reported at verbal autopsy suggested recent respiratory or gastrointestinal infection are these symptoms are similar to those reported in previous studies <xref rid="pone.0107663-Kerac1" ref-type="bibr">[5]</xref>, <xref rid="pone.0107663-Islam1" ref-type="bibr">[10]</xref>, <xref rid="pone.0107663-Ciliberto1" ref-type="bibr">[18]</xref>.</p><p>None of these findings are surprising as young and severely malnourished children are well recognized as being particularly vulnerable to new infections causing severe disease and associated with poor outcomes <xref rid="pone.0107663-Wiens1" ref-type="bibr">[8]</xref>. Many of these children at discharge were still malnourished and so likely to have persistent and profound immunodeficiency <xref rid="pone.0107663-Waterlow1" ref-type="bibr">[20]</xref>. In addition, they would have frequent exposure to infection, community-acquired upon return to home-based care as well as being at risk from nosocomial infections acquired during the inpatient stay in a crowded hospital.</p><p>The study also highlighted potential problems relating to access to care when this particularly vulnerable population developed new symptoms following discharge. Most died at home within one month of discharge with no contact with the hospital staff despite the recent offer of support and advice via mobile phones. It appeared that many sought treatment elsewhere including often with traditional healers. Care seeking with traditional healers has previously been reported as associated with an increased risk of death in children at-risk for severe and rapid-onset disease such as in this population <xref rid="pone.0107663-Mercer1" ref-type="bibr">[21]</xref>, <xref rid="pone.0107663-DSouza1" ref-type="bibr">[22]</xref>.</p><p>Our study has a number of important limitations. Primary outcome of survival status at 3 months was not known for 15% of those discharged. The HIV status of the study participants was not known despite this being an important risk factor for a poor outcome in African studies <xref rid="pone.0107663-Kerac1" ref-type="bibr">[5]</xref>. However, it is unlikely to be an important confounder in this population given that Bangladesh has a very low HIV prevalence among the adult population reported as <0.1% in 2011 <xref rid="pone.0107663-Marais1" ref-type="bibr">[13]</xref>. The reported pattern of illness prior to death relied on verbal autopsy which has recognized limitations <xref rid="pone.0107663-Qureshi1" ref-type="bibr">[23]</xref>. Analysis of post-discharge mortality and determinants of risk were not the primary outcomes of this study that determined sample size <xref rid="pone.0107663-Chisti2" ref-type="bibr">[14]</xref>. Finally, the study does not represent post-discharge mortality among malnourished children that have received complete “nutritional rehabilitation” because most of the study participants were discharged before they met the NRU’s criteria for discharge.</p><p>Despite the limitations, this study highlights the potential of a number of interventions that could improve post-discharge mortality in this population. As noted above, most of these children were discharged for home-based care before they met the nutritional criteria set by the NRU. It was reported that the main reason for this was pressure from the family who requested discharge once the child had apparently recovered from pneumonia. However, many of these children were still severely malnourished at discharge and it was observed that this was significantly associated with a poor outcome. Clearly, these children would still be profoundly immunosuppressed and vulnerable to severe infection at the time of discharge. A recent small study from the same institution reported a lower post-discharge death rate (2.8%) at 6-month follow-up among 180 Bangladeshi children with severe malnutrition that had completed full protocol of nutritional rehabilitation <xref rid="pone.0107663-Ashraf1" ref-type="bibr">[24]</xref>. However, the challenge may not be simply to seek to prolong the stay in the NRU until criteria are met as this does have some negative risks as well such as nosocomial infection, overcrowding of the NRU and poor compliance by families. Rather, it may be possible to better select those that would benefit from ongoing care in the NRU, and to improve home-based care to those that are discharged for home-based care.</p><p>Two potential options for home-based care that have received recent attention are to provide additional nutritional support as a form of RUTF and/or to provide preventive therapy to reduce the risk of severe infections such as cotrimoxazole preventive therapy (CPT). An intervention study that compared home-based RUTF to standard care in Malawian children with severe malnutrition reported significantly fewer deaths and less relapse among those receiving home-based RUTF at 2 month follow-up <xref rid="pone.0107663-Ciliberto1" ref-type="bibr">[18]</xref>. Reported illness of fever, cough and diarrhea were also all significantly less frequent in those that received RUTF. The benefit included those that were still severely malnourished by WHO criteria. CPT is widely recommended for HIV-infected children (and oncology patients) because it improves survival and reduces the incidence of serious infections such as invasive bacterial disease and <italic>Pneumocystis</italic> pneumonia <xref rid="pone.0107663-Chintu1" ref-type="bibr">[25]</xref>, <xref rid="pone.0107663-World3" ref-type="bibr">[26]</xref>. Future studies, such as recently undertaken in Kenya <xref rid="pone.0107663-Chang1" ref-type="bibr">[27]</xref> need to clarify if CPT provides post-discharge benefit for HIV-uninfected children with severe malnutrition. Attempts to influence the gut biome using probiotics have not been beneficial in one recently published study <xref rid="pone.0107663-Kerac1" ref-type="bibr">[5]</xref>. More intensive follow-up with ready access to health care advice such as by using mobile phones has shown benefit in previous studies <xref rid="pone.0107663-Zurovac1" ref-type="bibr">[28]</xref>. It is likely that different settings may require different solutions given the many potential determinants of mortality in this population. It is also difficult to determine the generalizability of the findings of this study.</p><p>In conclusion, post-discharge mortality is common among severely malnourished children with pneumonia and most of these deaths occur within one month of discharge. Risk factors for death include young age and severity of malnutrition and verbal autopsy suggests that death is preceded by recent respiratory or gastrointestinal infection, consistent with limited data from previous studies. There are a number of interventions that could potentially reduce post-discharge mortality in this population but a better understanding of the determinants of poor outcome and evidence from clinical studies are required.</p></sec></body><back><ack><p>We gratefully acknowledge these donors for their support and commitment to icddr,b’s research efforts. 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