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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tuberculosis case burden and treatment outcomes in children, adults and older adults, Vanuatu, 2007–2011</title><author><name sortKey="Tagaro, M" sort="Tagaro, M" uniqKey="Tagaro M" first="M." last="Tagaro">M. Tagaro</name><affiliation><nlm:aff id="aff1"> National TB Control Programme, Port Vila, Vanuatu</nlm:aff></affiliation></author><author><name sortKey="Harries, A D" sort="Harries, A D" uniqKey="Harries A" first="A. D." last="Harries">A. D. Harries</name><affiliation><nlm:aff id="aff2"> International Union Against Tuberculosis and Lung Disease, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff3"> London School of Hygiene & Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kool, B" sort="Kool, B" uniqKey="Kool B" first="B." last="Kool">B. Kool</name><affiliation><nlm:aff id="aff4"> School of Population Health, The University of Auckland, Auckland, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Ram, S" sort="Ram, S" uniqKey="Ram S" first="S." last="Ram">S. Ram</name><affiliation><nlm:aff id="aff5"> College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji</nlm:aff></affiliation></author><author><name sortKey="Viney, K" sort="Viney, K" uniqKey="Viney K" first="K." last="Viney">K. Viney</name><affiliation><nlm:aff id="aff6"> Secretariat of the Pacific Community, Nouméa, New Caledonia</nlm:aff></affiliation></author><author><name sortKey="Marais, B" sort="Marais, B" uniqKey="Marais B" first="B." last="Marais">B. Marais</name><affiliation><nlm:aff id="aff7"> The Sydney Emerging Infections and Biosecurity Institute, The University of Sydney, Sydney, New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Tarivonda, L" sort="Tarivonda, L" uniqKey="Tarivonda L" first="L." last="Tarivonda">L. Tarivonda</name><affiliation><nlm:aff id="aff8"> Department of Public Health, Ministry of Health, Port Vila, Vanuatu</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26477280</idno><idno type="pmc">4547594</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547594</idno><idno type="RBID">PMC:4547594</idno><idno type="doi">10.5588/pha.13.0074</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000237</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000237</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Tuberculosis case burden and treatment outcomes in children, adults and older adults, Vanuatu, 2007–2011</title><author><name sortKey="Tagaro, M" sort="Tagaro, M" uniqKey="Tagaro M" first="M." last="Tagaro">M. Tagaro</name><affiliation><nlm:aff id="aff1"> National TB Control Programme, Port Vila, Vanuatu</nlm:aff></affiliation></author><author><name sortKey="Harries, A D" sort="Harries, A D" uniqKey="Harries A" first="A. D." last="Harries">A. D. Harries</name><affiliation><nlm:aff id="aff2"> International Union Against Tuberculosis and Lung Disease, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff3"> London School of Hygiene & Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kool, B" sort="Kool, B" uniqKey="Kool B" first="B." last="Kool">B. Kool</name><affiliation><nlm:aff id="aff4"> School of Population Health, The University of Auckland, Auckland, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Ram, S" sort="Ram, S" uniqKey="Ram S" first="S." last="Ram">S. Ram</name><affiliation><nlm:aff id="aff5"> College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji</nlm:aff></affiliation></author><author><name sortKey="Viney, K" sort="Viney, K" uniqKey="Viney K" first="K." last="Viney">K. Viney</name><affiliation><nlm:aff id="aff6"> Secretariat of the Pacific Community, Nouméa, New Caledonia</nlm:aff></affiliation></author><author><name sortKey="Marais, B" sort="Marais, B" uniqKey="Marais B" first="B." last="Marais">B. Marais</name><affiliation><nlm:aff id="aff7"> The Sydney Emerging Infections and Biosecurity Institute, The University of Sydney, Sydney, New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Tarivonda, L" sort="Tarivonda, L" uniqKey="Tarivonda L" first="L." last="Tarivonda">L. Tarivonda</name><affiliation><nlm:aff id="aff8"> Department of Public Health, Ministry of Health, Port Vila, Vanuatu</nlm:aff></affiliation></author></analytic><series><title level="j">Public Health Action</title><idno type="eISSN">2220-8372</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Setting:</bold> All five DOTS centres in Vanuatu.</p><p><bold>Objectives:</bold> To determine across the age spectrum the tuberculosis (TB) case burden, disease pattern and treatment outcomes in patients registered between 2007 and 2011.</p><p><bold>Design:</bold> Retrospective cohort study involving reviews of TB registers and treatment cards.</p><p><bold>Results:</bold> Of 588 TB patients, 142 (24%) were children (aged 0–14 years), 327 (56%) adults (aged 15–54 years) and 119 (20%) were older adults (aged ⩾55 years; subdivided into 55–64 and ⩾65 years); 568 were new patients, 13 had been treated previously and 7 had unknown status. Compared with adults, children with new TB had a higher prevalence of extra-pulmonary TB (75% vs. 34%, OR 5.7, 95%CI 3.6–9.0) and a lower prevalence of smear-positive pulmonary TB (11% vs. 45%, OR 0.15, 95%CI 0.1–0.3), while older adults with new TB had a higher prevalence of smear-negative pulmonary TB (38% vs. 21%, OR 2.4, 95%CI 1.5–3.8). Overall TB treatment success was 83%, but in the second category of older adults (⩾65 years) treatment success was 67% and case fatality was 18%.</p><p><bold>Conclusion:</bold> Children and older adults constitute 45% of the TB burden in Vanuatu. Differences in disease patterns and poorer treatment outcomes in older adults have implications for policy and practice.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Public Health Action</journal-id><journal-id journal-id-type="iso-abbrev">Public Health Action</journal-id><journal-id journal-id-type="publisher-id">puha</journal-id><journal-id journal-id-type="pmc">The Union</journal-id><journal-title-group><journal-title>Public Health Action</journal-title></journal-title-group><issn pub-type="epub">2220-8372</issn><publisher><publisher-name>International Union Against Tuberculosis and Lung Disease</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26477280</article-id><article-id pub-id-type="pmc">4547594</article-id><article-id pub-id-type="doi">10.5588/pha.13.0074</article-id><article-id pub-id-type="sici">i2220-8372-4-s1-S14</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Tuberculosis case burden and treatment outcomes in children, adults and older adults, Vanuatu, 2007–2011</article-title><alt-title alt-title-type="running-head">TB burden and treatment outcomes in Vanuatu</alt-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Tagaro</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Harries</surname><given-names>A. D.</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kool</surname><given-names>B.</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Ram</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Viney</surname><given-names>K.</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Marais</surname><given-names>B.</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Tarivonda</surname><given-names>L.</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><aff id="aff1"><label>1</label> National TB Control Programme, Port Vila, Vanuatu</aff><aff id="aff2"><label>2</label> International Union Against Tuberculosis and Lung Disease, Paris, France</aff><aff id="aff3"><label>3</label> London School of Hygiene & Tropical Medicine, London, UK</aff><aff id="aff4"><label>4</label> School of Population Health, The University of Auckland, Auckland, New Zealand</aff><aff id="aff5"><label>5</label> College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji</aff><aff id="aff6"><label>6</label> Secretariat of the Pacific Community, Nouméa, New Caledonia</aff><aff id="aff7"><label>7</label> The Sydney Emerging Infections and Biosecurity Institute, The University of Sydney, Sydney, New South Wales, Australia</aff><aff id="aff8"><label>8</label> Department of Public Health, Ministry of Health, Port Vila, Vanuatu</aff></contrib-group><author-notes><corresp id="cor1"><bold>CORRESPONDENCE</bold> Markleen Tagaro, National TB Programme, PMB 9009, Port Vila, Vanuatu, Tel: (+678) 22512, Fax: (+678) 25438, e-mail: <email>mtagaro@vanuatu.gov.vu</email></corresp></author-notes><pub-date pub-type="ppub"><day>21</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>21</day><month>6</month><year>2014</year></pub-date><volume>4</volume><issue>Suppl 1</issue><fpage>S14</fpage><lpage>S18</lpage><history><date date-type="received"><day>8</day><month>9</month><year>2013</year></date><date date-type="accepted"><day>10</day><month>11</month><year>2013</year></date></history><permissions><copyright-statement>© 2014 The Union</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p><bold>Setting:</bold> All five DOTS centres in Vanuatu.</p><p><bold>Objectives:</bold> To determine across the age spectrum the tuberculosis (TB) case burden, disease pattern and treatment outcomes in patients registered between 2007 and 2011.</p><p><bold>Design:</bold> Retrospective cohort study involving reviews of TB registers and treatment cards.</p><p><bold>Results:</bold> Of 588 TB patients, 142 (24%) were children (aged 0–14 years), 327 (56%) adults (aged 15–54 years) and 119 (20%) were older adults (aged ⩾55 years; subdivided into 55–64 and ⩾65 years); 568 were new patients, 13 had been treated previously and 7 had unknown status. Compared with adults, children with new TB had a higher prevalence of extra-pulmonary TB (75% vs. 34%, OR 5.7, 95%CI 3.6–9.0) and a lower prevalence of smear-positive pulmonary TB (11% vs. 45%, OR 0.15, 95%CI 0.1–0.3), while older adults with new TB had a higher prevalence of smear-negative pulmonary TB (38% vs. 21%, OR 2.4, 95%CI 1.5–3.8). Overall TB treatment success was 83%, but in the second category of older adults (⩾65 years) treatment success was 67% and case fatality was 18%.</p><p><bold>Conclusion:</bold> Children and older adults constitute 45% of the TB burden in Vanuatu. Differences in disease patterns and poorer treatment outcomes in older adults have implications for policy and practice.</p></abstract><trans-abstract xml:lang="FR"><p><bold>Contexte :</bold> Les cinq centres DOTS du Vanuatu.</p><p><bold>Objectifs :</bold> Déterminer le fardeau de la tuberculose (TB) à travers les classes d'âge, le profil de la maladie et les résultats du traitement des patients enregistré entre 2007 et 2011.</p><p><bold>Schema :</bold> Etude de cohorte rétrospective impliquant des registres de TB et des cartes de traitement.</p><p><bold>Resultats :</bold> Sur 588 patients enregistrés, 142 (24%) étaient des enfants (âgés de 0–14 ans), 327 étaient des adultes (âgés de 15–54 ans) et 119 des adultes plus âgés (âgés de ⩾55 ans, subdivisés en 55–64 et ⩾65 ans). Parmi eux, 568 étaient des nouveaux patients, et 13 avaient déjà été traités ; pour 7 d'entre eux, le statut était inconnu. Comparés aux adultes, les enfants avec une TB nouvelle avaient une plus grande prévalence de TB extra pulmonaire (75% contre 34% ; OR 5,7 ; IC95% 3,6–9,0) et une prévalence plus faible de TB pulmonaire frottis positif (11% contre 45% ; OR 0,15 ; IC95% 0,3–0,3). Les adultes âgés de ⩾55 ans avaient une prévalence plus élevée de TB pulmonaire à frottis négatif (38% contre 21% ; OR 2,4 ; IC95% 1,5–3,8). Le succès du traitement de la TB a été de 83% pour l'ensemble du groupe, mais seulement de 67% pour les patients âgés de ⩾65 ans avec un taux de létalité de 18%.</p><p><bold>Conclusion :</bold> Les enfants et les adultes plus âgés constituent 45% du fardeau de la TB au Vanuatu. Les différences constatées en termes de profil de la maladie et de résultats thérapeutiques moins bons chez les adultes âgés ont des implications en matière de politique et de pratiques.</p></trans-abstract><trans-abstract xml:lang="ES"><p><bold>Marco de referencia:</bold> Los cinco centros de administración del DOTS en Vanuatu.</p><p><bold>Objetivos:</bold> Determinar la carga de morbilidad por tuberculosis (TB) en las diferentes edades, las características de la enfermedad y los desenlaces terapéuticos de los pacientes registrados entre el 2007 y el 2011.</p><p><bold>Método:</bold> Se llevó a cabo un estudio retrospectivo de cohortes con examen de los registros de TB y las tarjetas de tratamiento.</p><p><bold>Resultados:</bold> Se registraron 588 pacientes con TB, de los cuales 142 (24%) niños (de 0 a 14 años de edad), 327 (56%) adultos (de 15 a 54 años de edad) y 119 (20%) adultos (⩾55 años, divididos en 55–64 y ⩾65 años). Hubo 568 casos nuevos, 13 con antecedente de tratamiento antituberculoso y 7 cuya situación se desconocía. En comparación con los adultos, los casos nuevos de TB en los niños exhibieron una mayor prevalencia de localización extrapulmonar (75% contra 34%; OR 5,7; IC95% de 3,6 a 9,0) y una prevalencia más baja de TB con baciloscopia positiva (11% contra 45%; OR 0,15; IC95% de 0,1 a 0,3); los casos nuevos en los adultos mayores (de ⩾55 años) presentaron una prevalencia más alta de TB pulmonar con baciloscopia negativa (38% contra 21%; OR 2,4; IC95% de 1,5 a 3,8). En general, la tasa de tratamiento exitoso fue 83%, pero en los ancianos (⩾ 65 años) se alcanzó un tratamiento eficaz en el 67% y se observó un índice de letalidad de 18%.</p><p><bold>Conclusión:</bold> Los niños y los adultos mayores representan el 45% de la carga de morbilidad por TB en Vanuatu. Las diferencias en las características de la enfermedad y los desenlaces terapéuticos más desfavorables en los adultos mayores tienen consecuencias en las políticas y en la práctica clínica.</p></trans-abstract><kwd-group><kwd>tuberculosis</kwd><kwd>children</kwd><kwd>older adults</kwd><kwd>treatment outcomes</kwd><kwd>Vanuatu</kwd></kwd-group><counts><page-count count="5"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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