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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Consensus nomenclature for CD8<sup>+</sup> T cell phenotypes in cancer</title><author><name sortKey="Apetoh, Lionel" sort="Apetoh, Lionel" uniqKey="Apetoh L" first="Lionel" last="Apetoh">Lionel Apetoh</name><affiliation><nlm:aff id="af0001"><institution>INSERM; UMR 866</institution>, Dijon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>Centre Georges François Leclerc</institution>, Dijon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>Université de Bourgogne</institution>, Dijon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name><affiliation><nlm:aff id="af0004"><institution>QIMR Berghofer Medical Research Institute</institution>, Herston, Queensland,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Drake, Charles G" sort="Drake, Charles G" uniqKey="Drake C" first="Charles G." last="Drake">Charles G. Drake</name><affiliation><nlm:aff id="af0005"><institution>Sidney Kimmel Comprehensive Cancer Center; Johns Hopkins University School of Medicine</institution>, Baltimore, MD,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Abastado, Jean Pierre" sort="Abastado, Jean Pierre" uniqKey="Abastado J" first="Jean-Pierre" last="Abastado">Jean-Pierre Abastado</name><affiliation><nlm:aff id="af0006"><institution>Institut de Recherches Internationales Servier</institution>;<addr-line>53, rue Carnot</addr-line>, Suresnes,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Apte, Ron N" sort="Apte, Ron N" uniqKey="Apte R" first="Ron N." last="Apte">Ron N. Apte</name><affiliation><nlm:aff id="af0007"><institution>The Shraga Segal Department of Microbiology; Immunology and Genetics</institution>;<institution>The Faculty of Health Sciences, Ben Gurion University of the Negev</institution>, Beer Sheva,<country>Israel</country></nlm:aff></affiliation></author><author><name sortKey="Ayyoub, Maha" sort="Ayyoub, Maha" uniqKey="Ayyoub M" first="Maha" last="Ayyoub">Maha Ayyoub</name><affiliation><nlm:aff id="af0008"><institution>INSERM, Unité1102; Equipe Labellisée Ligue Contre le Cancer</institution>;<institution>Institut de Cancérologie de l’Ouest</institution>, Nantes-Saint Herblain;<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Blay, Jean Yves" sort="Blay, Jean Yves" uniqKey="Blay J" first="Jean-Yves" last="Blay">Jean-Yves Blay</name><affiliation><nlm:aff id="af0009"><institution>Cancer Research Center of Lyon; INSERM UMR 1052</institution>;<institution>CNRS UMR 5286</institution>, Centre Leon Berard, Lyon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0010"><institution>Medical Oncology Department</institution>, Lyon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bonneville, Marc" sort="Bonneville, Marc" uniqKey="Bonneville M" first="Marc" last="Bonneville">Marc Bonneville</name><affiliation><nlm:aff id="af0011"><institution>CRCNA, INSERM U892; CNRS UMR 6299</institution>, Nantes,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0012"><institution>Institut Mérieux</institution>, Lyon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Butterfield, Lisa H" sort="Butterfield, Lisa H" uniqKey="Butterfield L" first="Lisa H." last="Butterfield">Lisa H. Butterfield</name><affiliation><nlm:aff id="af0013"><institution>University of Pittsburgh Cancer Institute, Departments of Medicine, Surgery, and Immunology</institution>, Pittsburgh, PA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Caignard, Anne" sort="Caignard, Anne" uniqKey="Caignard A" first="Anne" last="Caignard">Anne Caignard</name><affiliation><nlm:aff id="af0014"><institution>INSERM UMR 1116</institution>, Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Castelli, Chiara" sort="Castelli, Chiara" uniqKey="Castelli C" first="Chiara" last="Castelli">Chiara Castelli</name><affiliation><nlm:aff id="af0015"><institution>Unit of Immunotherapy of Human Tumor; Department of Experimental Oncology and Molecular Medicine</institution>;<institution>Fondazione IRCCS Istituto Nazionale dei Tumori</institution>, Milan,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Cavallo, Federica" sort="Cavallo, Federica" uniqKey="Cavallo F" first="Federica" last="Cavallo">Federica Cavallo</name><affiliation><nlm:aff id="af0016"><institution>Department of Molecular Biotechnology and Health Sciences; Molecular Biotechnology Center, University of Torino</institution>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Celis, Esteban" sort="Celis, Esteban" uniqKey="Celis E" first="Esteban" last="Celis">Esteban Celis</name><affiliation><nlm:aff id="af0017"><institution>Cancer Immunology; Inflammation and Tolerance Program; Georgia Regents University Cancer Center</institution>; Augusta, GA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Chen, Lieping" sort="Chen, Lieping" uniqKey="Chen L" first="Lieping" last="Chen">Lieping Chen</name><affiliation><nlm:aff id="af0018"><institution>Department of Immunobiology and Yale Cancer Center; Yale University School of Medicine</institution>, New Haven, CT,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Colombo, Mario P" sort="Colombo, Mario P" uniqKey="Colombo M" first="Mario P." last="Colombo">Mario P. Colombo</name><affiliation><nlm:aff id="af0019"><institution>Molecular Immunology Unit; Department of Experimental Oncology and Molecular Medicine</institution>;<institution>Fondazione IRCCS Istituto Nazionale dei Tumori</institution>; Milan,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Comin Anduix, Bego A" sort="Comin Anduix, Bego A" uniqKey="Comin Anduix B" first="Bego A" last="Comin-Anduix">Bego A Comin-Anduix</name><affiliation><nlm:aff id="af0020"><institution>UCLA School of Medicine</institution>;<institution>Jonsson Comprehensive Cancer Center Los Angeles</institution>, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Coukos, Georges" sort="Coukos, Georges" uniqKey="Coukos G" first="Georges" last="Coukos">Georges Coukos</name><affiliation><nlm:aff id="af0021"><institution>Ludwig Center for Cancer Research; Department of Oncology; University of Lausanne</institution>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Dhodapkar, Madhav V" sort="Dhodapkar, Madhav V" uniqKey="Dhodapkar M" first="Madhav V." last="Dhodapkar">Madhav V. Dhodapkar</name><affiliation><nlm:aff id="af0018"><institution>Department of Immunobiology and Yale Cancer Center; Yale University School of Medicine</institution>, New Haven, CT,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Dranoff, Glenn" sort="Dranoff, Glenn" uniqKey="Dranoff G" first="Glenn" last="Dranoff">Glenn Dranoff</name><affiliation><nlm:aff id="af0022"><institution>Department of Medical Oncology and Cancer Vaccine Center; Dana-Farber Cancer Institute and Department of Medicine</institution>;<institution>Brigham and Women's Hospital and Harvard Medical School</institution>, Boston, MA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Frazer, Ian H" sort="Frazer, Ian H" uniqKey="Frazer I" first="Ian H." last="Frazer">Ian H. Frazer</name><affiliation><nlm:aff id="af0023"><institution>The University of Queensland</institution>, Queensland,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Fridman, Wolf Herve" sort="Fridman, Wolf Herve" uniqKey="Fridman W" first="Wolf-Hervé" last="Fridman">Wolf-Hervé Fridman</name><affiliation><nlm:aff id="af0024"><institution>Cordeliers Research Centre, University of Paris-Descartes</institution>, Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Gabrilovich, Dmitry I" sort="Gabrilovich, Dmitry I" uniqKey="Gabrilovich D" first="Dmitry I." last="Gabrilovich">Dmitry I. Gabrilovich</name><affiliation><nlm:aff id="af0025"><institution>Translational Tumor Immunology; The Wistar Institute</institution>, Philadelphia, PA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Gilboa, Eli" sort="Gilboa, Eli" uniqKey="Gilboa E" first="Eli" last="Gilboa">Eli Gilboa</name><affiliation><nlm:aff id="af0026"><institution>Department of Microbiology & Immunology; Dodson Interdisciplinary Immunotherapy Institute</institution>;<institution>Sylvester Comprehensive Cancer Center; Miller School of Medicine</institution>;<institution>University of Miami</institution>, Miami, FL,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Gnjatic, Sacha" sort="Gnjatic, Sacha" uniqKey="Gnjatic S" first="Sacha" last="Gnjatic">Sacha Gnjatic</name><affiliation><nlm:aff id="af0027"><institution>Tisch Cancer Institute; Icahn School of Medicine at Mount Sinai</institution>, New York, NY,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="J Ger, Dirk" sort="J Ger, Dirk" uniqKey="J Ger D" first="Dirk" last="J Ger">Dirk J Ger</name><affiliation><nlm:aff id="af0028"><institution>Department of Medical Oncology; National Center for Tumor Diseases</institution>;<institution>Internal Medicine VI; Heidelberg University Hospital</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Kalinski, Pawel" sort="Kalinski, Pawel" uniqKey="Kalinski P" first="Pawel" last="Kalinski">Pawel Kalinski</name><affiliation><nlm:aff id="af0029"><institution>Department of Surgery; University of Pittsburgh</institution>; Pittsburgh, PA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Kaufman, Howard L" sort="Kaufman, Howard L" uniqKey="Kaufman H" first="Howard L." last="Kaufman">Howard L. Kaufman</name><affiliation><nlm:aff id="af0030"><institution>Rutgers Cancer Institute of New Jersey</institution>, New Brunswick, NJ,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Kiessling, Rolf" sort="Kiessling, Rolf" uniqKey="Kiessling R" first="Rolf" last="Kiessling">Rolf Kiessling</name><affiliation><nlm:aff id="af0031"><institution>Department of Oncology/Pathology; Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Kirkwood, John" sort="Kirkwood, John" uniqKey="Kirkwood J" first="John" last="Kirkwood">John Kirkwood</name><affiliation><nlm:aff id="af0032"><institution>Division of Hematology/Oncology; Department of Medicine</institution>;<institution>School of Medicine; University of Pittsburgh</institution>, Pittsburgh; PA;<country>USA</country>;<institution>Melanoma and Skin Cancer Program; University of Pittsburgh Cancer Institute</institution>, Pittsburgh, PA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Knuth, Alexander" sort="Knuth, Alexander" uniqKey="Knuth A" first="Alexander" last="Knuth">Alexander Knuth</name><affiliation><nlm:aff id="af0033"><institution>National Center for Cancer Care & Research</institution>, Doha,<country>Qatar</country></nlm:aff></affiliation></author><author><name sortKey="Liblau, Roland" sort="Liblau, Roland" uniqKey="Liblau R" first="Roland" last="Liblau">Roland Liblau</name><affiliation><nlm:aff id="af0034"><institution>INSERM-UMR 1043</institution>; Toulouse,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0035"><institution>CNRS</institution>;<addr-line>U5282</addr-line>, Toulouse,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0036"><institution>Universite de Toulouse; UPS</institution>;<institution>Centre de Physiopathologie Toulouse Purpan (CPTP)</institution>; Toulouse,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0037"><institution>CHU Toulouse Purpan</institution>; Toulouse,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Lotze, Michael T" sort="Lotze, Michael T" uniqKey="Lotze M" first="Michael T." last="Lotze">Michael T. Lotze</name><affiliation><nlm:aff id="af0038"><institution>Hillman Cancer Center; University of Pittsburgh Schools of Health Sciences</institution>, Pittsburgh, PA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lugli, Enrico" sort="Lugli, Enrico" uniqKey="Lugli E" first="Enrico" last="Lugli">Enrico Lugli</name><affiliation><nlm:aff id="af0039"><institution>Unit of Clinical and Experimental Immunology; Humanitas Clinical and Research Center</institution>, Rozzano,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Marincola, Francesco" sort="Marincola, Francesco" uniqKey="Marincola F" first="Francesco" last="Marincola">Francesco Marincola</name><affiliation><nlm:aff id="af0040"><institution>Research Branch; Sidra Medical and Research Centre</institution>, Doha,<country>Qatar</country></nlm:aff></affiliation></author><author><name sortKey="Melero, Ignacio" sort="Melero, Ignacio" uniqKey="Melero I" first="Ignacio" last="Melero">Ignacio Melero</name><affiliation><nlm:aff id="af0041"><institution>Division of Oncology; Center for Applied Medical Research and Clinica Universidad de Navarra</institution>, Pamploma,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Melief, Cornelis J" sort="Melief, Cornelis J" uniqKey="Melief C" first="Cornelis J." last="Melief">Cornelis J. Melief</name><affiliation><nlm:aff id="af0042"><institution>Leiden University; ISA Pharmaceuticals</institution>,<country>Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Mempel, Thorsten R" sort="Mempel, Thorsten R" uniqKey="Mempel T" first="Thorsten R." last="Mempel">Thorsten R. Mempel</name><affiliation><nlm:aff id="af0043"><institution>Center for Immunology and Inflammatory Diseases; Massachusetts General Hospital</institution>;<institution>Harvard Medical School</institution>, Boston, MA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Mittendorf, Elizabeth A" sort="Mittendorf, Elizabeth A" uniqKey="Mittendorf E" first="Elizabeth A." last="Mittendorf">Elizabeth A. Mittendorf</name><affiliation><nlm:aff id="af0044"><institution>Deparment of Surgical Oncology; University of Texas MD Anderson Cancer Center</institution>, Houston, TX,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Odun, Kunle" sort="Odun, Kunle" uniqKey="Odun K" first="Kunle" last="Odun">Kunle Odun</name><affiliation><nlm:aff id="af0045"><institution>Departments of Gynecologic Oncology and Immunology; Roswell Park Cancer Institute</institution>, Buffalo, NY,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Overwijk, Willem W" sort="Overwijk, Willem W" uniqKey="Overwijk W" first="Willem W." last="Overwijk">Willem W. Overwijk</name><affiliation><nlm:aff id="af0046"><institution>Department of Melanoma Medical Oncology; University of Texas MD Anderson Cancer Center</institution>, Houston, TX,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Palucka, Anna Karolina" sort="Palucka, Anna Karolina" uniqKey="Palucka A" first="Anna Karolina" last="Palucka">Anna Karolina Palucka</name><affiliation><nlm:aff id="af0047"><institution>The Jackson Laboratory for Genomic Medicine</institution>, Farmington, CT,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Parmiani, Giorgio" sort="Parmiani, Giorgio" uniqKey="Parmiani G" first="Giorgio" last="Parmiani">Giorgio Parmiani</name><affiliation><nlm:aff id="af0048"><institution>Division of Medical Oncology and Immunotherapy; University Hospital</institution>, Siena,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name><affiliation><nlm:aff id="af0020"><institution>UCLA School of Medicine</institution>;<institution>Jonsson Comprehensive Cancer Center Los Angeles</institution>, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Romero, Pedro" sort="Romero, Pedro" uniqKey="Romero P" first="Pedro" last="Romero">Pedro Romero</name><affiliation><nlm:aff id="af0021"><institution>Ludwig Center for Cancer Research; Department of Oncology; University of Lausanne</institution>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Schreiber, Robert D" sort="Schreiber, Robert D" uniqKey="Schreiber R" first="Robert D." last="Schreiber">Robert D. Schreiber</name><affiliation><nlm:aff id="af0049"><institution>Department of Pathology and Immunology; Washington University School of Medicine</institution>, St. Louis, MO<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Schuler, Gerold" sort="Schuler, Gerold" uniqKey="Schuler G" first="Gerold" last="Schuler">Gerold Schuler</name><affiliation><nlm:aff id="af0050"><institution>Department of Dermatology; Universitatsklinikum Erlangen</institution>, Erlangen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Srivastava, Pramod K" sort="Srivastava, Pramod K" uniqKey="Srivastava P" first="Pramod K." last="Srivastava">Pramod K. Srivastava</name><affiliation><nlm:aff id="af0051"><institution>Center for Immunotherapy of Cancer and Infectious Diseases; Carole and Ray Neag Comprehensive Cancer Center</institution>;<institution>University of Connecticut Health Center</institution>, Farmington, CT,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Tartour, Eric" sort="Tartour, Eric" uniqKey="Tartour E" first="Eric" last="Tartour">Eric Tartour</name><affiliation><nlm:aff id="af0052"><institution>Department of Clinical Oncology, INSERM U970; Universite Paris Descartes</institution>;<institution>Sorbonne Paris-Cité; Paris</institution>;<institution>France; Hôpital Européen Georges Pompidou</institution>;<institution>Service d’Immunologie Biologique</institution>; Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Valmori, Danila" sort="Valmori, Danila" uniqKey="Valmori D" first="Danila" last="Valmori">Danila Valmori</name><affiliation><nlm:aff id="af0008"><institution>INSERM, Unité1102; Equipe Labellisée Ligue Contre le Cancer</institution>;<institution>Institut de Cancérologie de l’Ouest</institution>, Nantes-Saint Herblain;<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0053"><institution>Faculty of Medicine, University of Nantes, 44035 Nantes, France</institution></nlm:aff></affiliation></author><author><name sortKey="Van Der Burg, Sjoerd H" sort="Van Der Burg, Sjoerd H" uniqKey="Van Der Burg S" first="Sjoerd H." last="Van Der Burg">Sjoerd H. Van Der Burg</name><affiliation><nlm:aff id="af0054"><institution>Leiden University Medical Center</institution>, Leiden,<country>Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van Der Bruggen, Pierre" sort="Van Der Bruggen, Pierre" uniqKey="Van Der Bruggen P" first="Pierre" last="Van Der Bruggen">Pierre Van Der Bruggen</name><affiliation><nlm:aff id="af0055"><institution>Ludwig Institute for Cancer Research; BrusselsBranch de Duve Institute</institution>;<institution>Université Catholique de Louvain</institution>, Brussels,<country>Blegium</country></nlm:aff></affiliation></author><author><name sortKey="Van Den Eynde, Benoit J" sort="Van Den Eynde, Benoit J" uniqKey="Van Den Eynde B" first="Benoît J." last="Van Den Eynde">Benoît J. Van Den Eynde</name><affiliation><nlm:aff id="af0055"><institution>Ludwig Institute for Cancer Research; BrusselsBranch de Duve Institute</institution>;<institution>Université Catholique de Louvain</institution>, Brussels,<country>Blegium</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Ena" sort="Wang, Ena" uniqKey="Wang E" first="Ena" last="Wang">Ena Wang</name><affiliation><nlm:aff id="af0040"><institution>Research Branch; Sidra Medical and Research Centre</institution>, Doha,<country>Qatar</country></nlm:aff></affiliation></author><author><name sortKey="Zou, Weiping" sort="Zou, Weiping" uniqKey="Zou W" first="Weiping" last="Zou">Weiping Zou</name><affiliation><nlm:aff id="af0056"><institution>Department of Surgery; University of Michigan School of Medicine</institution>,<institution>Ann Arbor</institution>, MI,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Whiteside, Theresa L" sort="Whiteside, Theresa L" uniqKey="Whiteside T" first="Theresa L." last="Whiteside">Theresa L. Whiteside</name><affiliation><nlm:aff id="af0057"><institution>Department of Pathology; Immunology, and Otolaryngology</institution>;<institution>University of Pittsburgh Cancer Institute</institution>, Pittsburgh, PA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Speiser, Daniel E" sort="Speiser, Daniel E" uniqKey="Speiser D" first="Daniel E." last="Speiser">Daniel E. Speiser</name><affiliation><nlm:aff id="af0021"><institution>Ludwig Center for Cancer Research; Department of Oncology; University of Lausanne</institution>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Pardoll, Drew M" sort="Pardoll, Drew M" uniqKey="Pardoll D" first="Drew M." last="Pardoll">Drew M. Pardoll</name><affiliation><nlm:aff id="af0005"><institution>Sidney Kimmel Comprehensive Cancer Center; Johns Hopkins University School of Medicine</institution>, Baltimore, MD,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Restifo, Nicholas P" sort="Restifo, Nicholas P" uniqKey="Restifo N" first="Nicholas P." last="Restifo">Nicholas P. Restifo</name><affiliation><nlm:aff id="af0058"><institution>National Cancer Institute; National Institutes of Health</institution>, Bethesda, MD,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Anderson, Ana C" sort="Anderson, Ana C" uniqKey="Anderson A" first="Ana C." last="Anderson">Ana C. Anderson</name><affiliation><nlm:aff id="af0059"><institution>Evergrande Center for Immunologic Diseases; Ann Romney Center for Neurologic Diseases</institution>;<institution>Brigham and Women's Hospital and Harvard Medical School</institution>, Boston, MA<country>USA</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26137416</idno><idno type="pmc">4485711</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485711</idno><idno type="RBID">PMC:4485711</idno><idno type="doi">10.1080/2162402X.2014.998538</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000215</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000215</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Consensus nomenclature for CD8<sup>+</sup> T cell phenotypes in cancer</title><author><name sortKey="Apetoh, Lionel" sort="Apetoh, Lionel" uniqKey="Apetoh L" first="Lionel" last="Apetoh">Lionel Apetoh</name><affiliation><nlm:aff id="af0001"><institution>INSERM; UMR 866</institution>, Dijon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>Centre Georges François Leclerc</institution>, Dijon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>Université de Bourgogne</institution>, Dijon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name><affiliation><nlm:aff id="af0004"><institution>QIMR Berghofer Medical Research Institute</institution>, Herston, Queensland,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Drake, Charles G" sort="Drake, Charles G" uniqKey="Drake C" first="Charles G." last="Drake">Charles G. Drake</name><affiliation><nlm:aff id="af0005"><institution>Sidney Kimmel Comprehensive Cancer Center; Johns Hopkins University School of Medicine</institution>, Baltimore, MD,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Abastado, Jean Pierre" sort="Abastado, Jean Pierre" uniqKey="Abastado J" first="Jean-Pierre" last="Abastado">Jean-Pierre Abastado</name><affiliation><nlm:aff id="af0006"><institution>Institut de Recherches Internationales Servier</institution>;<addr-line>53, rue Carnot</addr-line>, Suresnes,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Apte, Ron N" sort="Apte, Ron N" uniqKey="Apte R" first="Ron N." last="Apte">Ron N. Apte</name><affiliation><nlm:aff id="af0007"><institution>The Shraga Segal Department of Microbiology; Immunology and Genetics</institution>;<institution>The Faculty of Health Sciences, Ben Gurion University of the Negev</institution>, Beer Sheva,<country>Israel</country></nlm:aff></affiliation></author><author><name sortKey="Ayyoub, Maha" sort="Ayyoub, Maha" uniqKey="Ayyoub M" first="Maha" last="Ayyoub">Maha Ayyoub</name><affiliation><nlm:aff id="af0008"><institution>INSERM, Unité1102; Equipe Labellisée Ligue Contre le Cancer</institution>;<institution>Institut de Cancérologie de l’Ouest</institution>, Nantes-Saint Herblain;<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Blay, Jean Yves" sort="Blay, Jean Yves" uniqKey="Blay J" first="Jean-Yves" last="Blay">Jean-Yves Blay</name><affiliation><nlm:aff id="af0009"><institution>Cancer Research Center of Lyon; INSERM UMR 1052</institution>;<institution>CNRS UMR 5286</institution>, Centre Leon Berard, Lyon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0010"><institution>Medical Oncology Department</institution>, Lyon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bonneville, Marc" sort="Bonneville, Marc" uniqKey="Bonneville M" first="Marc" last="Bonneville">Marc Bonneville</name><affiliation><nlm:aff id="af0011"><institution>CRCNA, INSERM U892; CNRS UMR 6299</institution>, Nantes,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0012"><institution>Institut Mérieux</institution>, Lyon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Butterfield, Lisa H" sort="Butterfield, Lisa H" uniqKey="Butterfield L" first="Lisa H." last="Butterfield">Lisa H. Butterfield</name><affiliation><nlm:aff id="af0013"><institution>University of Pittsburgh Cancer Institute, Departments of Medicine, Surgery, and Immunology</institution>, Pittsburgh, PA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Caignard, Anne" sort="Caignard, Anne" uniqKey="Caignard A" first="Anne" last="Caignard">Anne Caignard</name><affiliation><nlm:aff id="af0014"><institution>INSERM UMR 1116</institution>, Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Castelli, Chiara" sort="Castelli, Chiara" uniqKey="Castelli C" first="Chiara" last="Castelli">Chiara Castelli</name><affiliation><nlm:aff id="af0015"><institution>Unit of Immunotherapy of Human Tumor; Department of Experimental Oncology and Molecular Medicine</institution>;<institution>Fondazione IRCCS Istituto Nazionale dei Tumori</institution>, Milan,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Cavallo, Federica" sort="Cavallo, Federica" uniqKey="Cavallo F" first="Federica" last="Cavallo">Federica Cavallo</name><affiliation><nlm:aff id="af0016"><institution>Department of Molecular Biotechnology and Health Sciences; Molecular Biotechnology Center, University of Torino</institution>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Celis, Esteban" sort="Celis, Esteban" uniqKey="Celis E" first="Esteban" last="Celis">Esteban Celis</name><affiliation><nlm:aff id="af0017"><institution>Cancer Immunology; Inflammation and Tolerance Program; Georgia Regents University Cancer Center</institution>; Augusta, GA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Chen, Lieping" sort="Chen, Lieping" uniqKey="Chen L" first="Lieping" last="Chen">Lieping Chen</name><affiliation><nlm:aff id="af0018"><institution>Department of Immunobiology and Yale Cancer Center; Yale University School of Medicine</institution>, New Haven, CT,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Colombo, Mario P" sort="Colombo, Mario P" uniqKey="Colombo M" first="Mario P." last="Colombo">Mario P. Colombo</name><affiliation><nlm:aff id="af0019"><institution>Molecular Immunology Unit; Department of Experimental Oncology and Molecular Medicine</institution>;<institution>Fondazione IRCCS Istituto Nazionale dei Tumori</institution>; Milan,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Comin Anduix, Bego A" sort="Comin Anduix, Bego A" uniqKey="Comin Anduix B" first="Bego A" last="Comin-Anduix">Bego A Comin-Anduix</name><affiliation><nlm:aff id="af0020"><institution>UCLA School of Medicine</institution>;<institution>Jonsson Comprehensive Cancer Center Los Angeles</institution>, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Coukos, Georges" sort="Coukos, Georges" uniqKey="Coukos G" first="Georges" last="Coukos">Georges Coukos</name><affiliation><nlm:aff id="af0021"><institution>Ludwig Center for Cancer Research; Department of Oncology; University of Lausanne</institution>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Dhodapkar, Madhav V" sort="Dhodapkar, Madhav V" uniqKey="Dhodapkar M" first="Madhav V." last="Dhodapkar">Madhav V. Dhodapkar</name><affiliation><nlm:aff id="af0018"><institution>Department of Immunobiology and Yale Cancer Center; Yale University School of Medicine</institution>, New Haven, CT,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Dranoff, Glenn" sort="Dranoff, Glenn" uniqKey="Dranoff G" first="Glenn" last="Dranoff">Glenn Dranoff</name><affiliation><nlm:aff id="af0022"><institution>Department of Medical Oncology and Cancer Vaccine Center; Dana-Farber Cancer Institute and Department of Medicine</institution>;<institution>Brigham and Women's Hospital and Harvard Medical School</institution>, Boston, MA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Frazer, Ian H" sort="Frazer, Ian H" uniqKey="Frazer I" first="Ian H." last="Frazer">Ian H. Frazer</name><affiliation><nlm:aff id="af0023"><institution>The University of Queensland</institution>, Queensland,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Fridman, Wolf Herve" sort="Fridman, Wolf Herve" uniqKey="Fridman W" first="Wolf-Hervé" last="Fridman">Wolf-Hervé Fridman</name><affiliation><nlm:aff id="af0024"><institution>Cordeliers Research Centre, University of Paris-Descartes</institution>, Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Gabrilovich, Dmitry I" sort="Gabrilovich, Dmitry I" uniqKey="Gabrilovich D" first="Dmitry I." last="Gabrilovich">Dmitry I. Gabrilovich</name><affiliation><nlm:aff id="af0025"><institution>Translational Tumor Immunology; The Wistar Institute</institution>, Philadelphia, PA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Gilboa, Eli" sort="Gilboa, Eli" uniqKey="Gilboa E" first="Eli" last="Gilboa">Eli Gilboa</name><affiliation><nlm:aff id="af0026"><institution>Department of Microbiology & Immunology; Dodson Interdisciplinary Immunotherapy Institute</institution>;<institution>Sylvester Comprehensive Cancer Center; Miller School of Medicine</institution>;<institution>University of Miami</institution>, Miami, FL,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Gnjatic, Sacha" sort="Gnjatic, Sacha" uniqKey="Gnjatic S" first="Sacha" last="Gnjatic">Sacha Gnjatic</name><affiliation><nlm:aff id="af0027"><institution>Tisch Cancer Institute; Icahn School of Medicine at Mount Sinai</institution>, New York, NY,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="J Ger, Dirk" sort="J Ger, Dirk" uniqKey="J Ger D" first="Dirk" last="J Ger">Dirk J Ger</name><affiliation><nlm:aff id="af0028"><institution>Department of Medical Oncology; National Center for Tumor Diseases</institution>;<institution>Internal Medicine VI; Heidelberg University Hospital</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Kalinski, Pawel" sort="Kalinski, Pawel" uniqKey="Kalinski P" first="Pawel" last="Kalinski">Pawel Kalinski</name><affiliation><nlm:aff id="af0029"><institution>Department of Surgery; University of Pittsburgh</institution>; Pittsburgh, PA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Kaufman, Howard L" sort="Kaufman, Howard L" uniqKey="Kaufman H" first="Howard L." last="Kaufman">Howard L. Kaufman</name><affiliation><nlm:aff id="af0030"><institution>Rutgers Cancer Institute of New Jersey</institution>, New Brunswick, NJ,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Kiessling, Rolf" sort="Kiessling, Rolf" uniqKey="Kiessling R" first="Rolf" last="Kiessling">Rolf Kiessling</name><affiliation><nlm:aff id="af0031"><institution>Department of Oncology/Pathology; Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Kirkwood, John" sort="Kirkwood, John" uniqKey="Kirkwood J" first="John" last="Kirkwood">John Kirkwood</name><affiliation><nlm:aff id="af0032"><institution>Division of Hematology/Oncology; Department of Medicine</institution>;<institution>School of Medicine; University of Pittsburgh</institution>, Pittsburgh; PA;<country>USA</country>;<institution>Melanoma and Skin Cancer Program; University of Pittsburgh Cancer Institute</institution>, Pittsburgh, PA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Knuth, Alexander" sort="Knuth, Alexander" uniqKey="Knuth A" first="Alexander" last="Knuth">Alexander Knuth</name><affiliation><nlm:aff id="af0033"><institution>National Center for Cancer Care & Research</institution>, Doha,<country>Qatar</country></nlm:aff></affiliation></author><author><name sortKey="Liblau, Roland" sort="Liblau, Roland" uniqKey="Liblau R" first="Roland" last="Liblau">Roland Liblau</name><affiliation><nlm:aff id="af0034"><institution>INSERM-UMR 1043</institution>; Toulouse,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0035"><institution>CNRS</institution>;<addr-line>U5282</addr-line>, Toulouse,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0036"><institution>Universite de Toulouse; UPS</institution>;<institution>Centre de Physiopathologie Toulouse Purpan (CPTP)</institution>; Toulouse,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0037"><institution>CHU Toulouse Purpan</institution>; Toulouse,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Lotze, Michael T" sort="Lotze, Michael T" uniqKey="Lotze M" first="Michael T." last="Lotze">Michael T. Lotze</name><affiliation><nlm:aff id="af0038"><institution>Hillman Cancer Center; University of Pittsburgh Schools of Health Sciences</institution>, Pittsburgh, PA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lugli, Enrico" sort="Lugli, Enrico" uniqKey="Lugli E" first="Enrico" last="Lugli">Enrico Lugli</name><affiliation><nlm:aff id="af0039"><institution>Unit of Clinical and Experimental Immunology; Humanitas Clinical and Research Center</institution>, Rozzano,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Marincola, Francesco" sort="Marincola, Francesco" uniqKey="Marincola F" first="Francesco" last="Marincola">Francesco Marincola</name><affiliation><nlm:aff id="af0040"><institution>Research Branch; Sidra Medical and Research Centre</institution>, Doha,<country>Qatar</country></nlm:aff></affiliation></author><author><name sortKey="Melero, Ignacio" sort="Melero, Ignacio" uniqKey="Melero I" first="Ignacio" last="Melero">Ignacio Melero</name><affiliation><nlm:aff id="af0041"><institution>Division of Oncology; Center for Applied Medical Research and Clinica Universidad de Navarra</institution>, Pamploma,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Melief, Cornelis J" sort="Melief, Cornelis J" uniqKey="Melief C" first="Cornelis J." last="Melief">Cornelis J. Melief</name><affiliation><nlm:aff id="af0042"><institution>Leiden University; ISA Pharmaceuticals</institution>,<country>Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Mempel, Thorsten R" sort="Mempel, Thorsten R" uniqKey="Mempel T" first="Thorsten R." last="Mempel">Thorsten R. Mempel</name><affiliation><nlm:aff id="af0043"><institution>Center for Immunology and Inflammatory Diseases; Massachusetts General Hospital</institution>;<institution>Harvard Medical School</institution>, Boston, MA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Mittendorf, Elizabeth A" sort="Mittendorf, Elizabeth A" uniqKey="Mittendorf E" first="Elizabeth A." last="Mittendorf">Elizabeth A. Mittendorf</name><affiliation><nlm:aff id="af0044"><institution>Deparment of Surgical Oncology; University of Texas MD Anderson Cancer Center</institution>, Houston, TX,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Odun, Kunle" sort="Odun, Kunle" uniqKey="Odun K" first="Kunle" last="Odun">Kunle Odun</name><affiliation><nlm:aff id="af0045"><institution>Departments of Gynecologic Oncology and Immunology; Roswell Park Cancer Institute</institution>, Buffalo, NY,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Overwijk, Willem W" sort="Overwijk, Willem W" uniqKey="Overwijk W" first="Willem W." last="Overwijk">Willem W. Overwijk</name><affiliation><nlm:aff id="af0046"><institution>Department of Melanoma Medical Oncology; University of Texas MD Anderson Cancer Center</institution>, Houston, TX,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Palucka, Anna Karolina" sort="Palucka, Anna Karolina" uniqKey="Palucka A" first="Anna Karolina" last="Palucka">Anna Karolina Palucka</name><affiliation><nlm:aff id="af0047"><institution>The Jackson Laboratory for Genomic Medicine</institution>, Farmington, CT,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Parmiani, Giorgio" sort="Parmiani, Giorgio" uniqKey="Parmiani G" first="Giorgio" last="Parmiani">Giorgio Parmiani</name><affiliation><nlm:aff id="af0048"><institution>Division of Medical Oncology and Immunotherapy; University Hospital</institution>, Siena,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name><affiliation><nlm:aff id="af0020"><institution>UCLA School of Medicine</institution>;<institution>Jonsson Comprehensive Cancer Center Los Angeles</institution>, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Romero, Pedro" sort="Romero, Pedro" uniqKey="Romero P" first="Pedro" last="Romero">Pedro Romero</name><affiliation><nlm:aff id="af0021"><institution>Ludwig Center for Cancer Research; Department of Oncology; University of Lausanne</institution>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Schreiber, Robert D" sort="Schreiber, Robert D" uniqKey="Schreiber R" first="Robert D." last="Schreiber">Robert D. Schreiber</name><affiliation><nlm:aff id="af0049"><institution>Department of Pathology and Immunology; Washington University School of Medicine</institution>, St. Louis, MO<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Schuler, Gerold" sort="Schuler, Gerold" uniqKey="Schuler G" first="Gerold" last="Schuler">Gerold Schuler</name><affiliation><nlm:aff id="af0050"><institution>Department of Dermatology; Universitatsklinikum Erlangen</institution>, Erlangen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Srivastava, Pramod K" sort="Srivastava, Pramod K" uniqKey="Srivastava P" first="Pramod K." last="Srivastava">Pramod K. Srivastava</name><affiliation><nlm:aff id="af0051"><institution>Center for Immunotherapy of Cancer and Infectious Diseases; Carole and Ray Neag Comprehensive Cancer Center</institution>;<institution>University of Connecticut Health Center</institution>, Farmington, CT,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Tartour, Eric" sort="Tartour, Eric" uniqKey="Tartour E" first="Eric" last="Tartour">Eric Tartour</name><affiliation><nlm:aff id="af0052"><institution>Department of Clinical Oncology, INSERM U970; Universite Paris Descartes</institution>;<institution>Sorbonne Paris-Cité; Paris</institution>;<institution>France; Hôpital Européen Georges Pompidou</institution>;<institution>Service d’Immunologie Biologique</institution>; Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Valmori, Danila" sort="Valmori, Danila" uniqKey="Valmori D" first="Danila" last="Valmori">Danila Valmori</name><affiliation><nlm:aff id="af0008"><institution>INSERM, Unité1102; Equipe Labellisée Ligue Contre le Cancer</institution>;<institution>Institut de Cancérologie de l’Ouest</institution>, Nantes-Saint Herblain;<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0053"><institution>Faculty of Medicine, University of Nantes, 44035 Nantes, France</institution></nlm:aff></affiliation></author><author><name sortKey="Van Der Burg, Sjoerd H" sort="Van Der Burg, Sjoerd H" uniqKey="Van Der Burg S" first="Sjoerd H." last="Van Der Burg">Sjoerd H. Van Der Burg</name><affiliation><nlm:aff id="af0054"><institution>Leiden University Medical Center</institution>, Leiden,<country>Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van Der Bruggen, Pierre" sort="Van Der Bruggen, Pierre" uniqKey="Van Der Bruggen P" first="Pierre" last="Van Der Bruggen">Pierre Van Der Bruggen</name><affiliation><nlm:aff id="af0055"><institution>Ludwig Institute for Cancer Research; BrusselsBranch de Duve Institute</institution>;<institution>Université Catholique de Louvain</institution>, Brussels,<country>Blegium</country></nlm:aff></affiliation></author><author><name sortKey="Van Den Eynde, Benoit J" sort="Van Den Eynde, Benoit J" uniqKey="Van Den Eynde B" first="Benoît J." last="Van Den Eynde">Benoît J. Van Den Eynde</name><affiliation><nlm:aff id="af0055"><institution>Ludwig Institute for Cancer Research; BrusselsBranch de Duve Institute</institution>;<institution>Université Catholique de Louvain</institution>, Brussels,<country>Blegium</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Ena" sort="Wang, Ena" uniqKey="Wang E" first="Ena" last="Wang">Ena Wang</name><affiliation><nlm:aff id="af0040"><institution>Research Branch; Sidra Medical and Research Centre</institution>, Doha,<country>Qatar</country></nlm:aff></affiliation></author><author><name sortKey="Zou, Weiping" sort="Zou, Weiping" uniqKey="Zou W" first="Weiping" last="Zou">Weiping Zou</name><affiliation><nlm:aff id="af0056"><institution>Department of Surgery; University of Michigan School of Medicine</institution>,<institution>Ann Arbor</institution>, MI,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Whiteside, Theresa L" sort="Whiteside, Theresa L" uniqKey="Whiteside T" first="Theresa L." last="Whiteside">Theresa L. Whiteside</name><affiliation><nlm:aff id="af0057"><institution>Department of Pathology; Immunology, and Otolaryngology</institution>;<institution>University of Pittsburgh Cancer Institute</institution>, Pittsburgh, PA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Speiser, Daniel E" sort="Speiser, Daniel E" uniqKey="Speiser D" first="Daniel E." last="Speiser">Daniel E. Speiser</name><affiliation><nlm:aff id="af0021"><institution>Ludwig Center for Cancer Research; Department of Oncology; University of Lausanne</institution>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Pardoll, Drew M" sort="Pardoll, Drew M" uniqKey="Pardoll D" first="Drew M." last="Pardoll">Drew M. Pardoll</name><affiliation><nlm:aff id="af0005"><institution>Sidney Kimmel Comprehensive Cancer Center; Johns Hopkins University School of Medicine</institution>, Baltimore, MD,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Restifo, Nicholas P" sort="Restifo, Nicholas P" uniqKey="Restifo N" first="Nicholas P." last="Restifo">Nicholas P. Restifo</name><affiliation><nlm:aff id="af0058"><institution>National Cancer Institute; National Institutes of Health</institution>, Bethesda, MD,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Anderson, Ana C" sort="Anderson, Ana C" uniqKey="Anderson A" first="Ana C." last="Anderson">Ana C. Anderson</name><affiliation><nlm:aff id="af0059"><institution>Evergrande Center for Immunologic Diseases; Ann Romney Center for Neurologic Diseases</institution>;<institution>Brigham and Women's Hospital and Harvard Medical School</institution>, Boston, MA<country>USA</country></nlm:aff></affiliation></author></analytic><series><title level="j">Oncoimmunology</title><idno type="ISSN">2162-4011</idno><idno type="eISSN">2162-402X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Whereas preclinical investigations and clinical studies have established that CD8<sup>+</sup> T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8<sup>+</sup> T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8<sup>+</sup> T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8<sup>+</sup> T cell immunity, leading to the emergence of dysfunctional CD8<sup>+</sup> T cells. The existence of different types of CD8<sup>+</sup> T cells in cancer calls for a more precise definition of the CD8<sup>+</sup> T cell immune phenotypes in cancer and the abandonment of the generic terms “pro-tumor” and “antitumor.” Based on recent studies investigating the functions of CD8<sup>+</sup> T cells in cancer, we here propose some guidelines to precisely define the functional states of CD8<sup>+</sup> T cells in cancer.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Oncoimmunology</journal-id><journal-id journal-id-type="iso-abbrev">Oncoimmunology</journal-id><journal-id journal-id-type="pmc">KONI</journal-id><journal-title-group><journal-title>Oncoimmunology</journal-title></journal-title-group><issn pub-type="ppub">2162-4011</issn><issn pub-type="epub">2162-402X</issn><publisher><publisher-name>Taylor & Francis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26137416</article-id><article-id pub-id-type="pmc">4485711</article-id><article-id pub-id-type="publisher-id">998538</article-id><article-id pub-id-type="doi">10.1080/2162402X.2014.998538</article-id><article-categories><subj-group subj-group-type="heading"><subject>Point of View</subject></subj-group></article-categories><title-group><article-title>Consensus nomenclature for CD8<sup>+</sup> T cell phenotypes in cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Apetoh</surname><given-names>Lionel</given-names></name><xref ref-type="aff" rid="af0001"><sup>1</sup></xref><xref ref-type="aff" rid="af0002"><sup>2</sup></xref><xref ref-type="aff" rid="af0003"><sup>3</sup></xref><xref ref-type="corresp" rid="an0001"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Smyth</surname><given-names>Mark J.</given-names></name><xref ref-type="aff" rid="af0004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Drake</surname><given-names>Charles G.</given-names></name><xref ref-type="aff" rid="af0005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Abastado</surname><given-names>Jean-Pierre</given-names></name><xref ref-type="aff" rid="af0006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Apte</surname><given-names>Ron N.</given-names></name><xref ref-type="aff" rid="af0007"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ayyoub</surname><given-names>Maha</given-names></name><xref ref-type="aff" rid="af0008"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Blay</surname><given-names>Jean-Yves</given-names></name><xref ref-type="aff" rid="af0009"><sup>9</sup></xref><xref ref-type="aff" rid="af0010"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bonneville</surname><given-names>Marc</given-names></name><xref ref-type="aff" rid="af0011"><sup>11</sup></xref><xref ref-type="aff" rid="af0012"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Butterfield</surname><given-names>Lisa H.</given-names></name><xref ref-type="aff" rid="af0013"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Caignard</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="af0014"><sup>14</sup></xref></contrib><contrib contrib-type="author"><name><surname>Castelli</surname><given-names>Chiara</given-names></name><xref ref-type="aff" rid="af0015"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cavallo</surname><given-names>Federica</given-names></name><xref ref-type="aff" rid="af0016"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Celis</surname><given-names>Esteban</given-names></name><xref ref-type="aff" rid="af0017"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Lieping</given-names></name><xref ref-type="aff" rid="af0018"><sup>18</sup></xref></contrib><contrib contrib-type="author"><name><surname>Colombo</surname><given-names>Mario P.</given-names></name><xref ref-type="aff" rid="af0019"><sup>19</sup></xref></contrib><contrib contrib-type="author"><name><surname>Comin-Anduix</surname><given-names>Begoña</given-names></name><xref ref-type="aff" rid="af0020"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Coukos</surname><given-names>Georges</given-names></name><xref ref-type="aff" rid="af0021"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dhodapkar</surname><given-names>Madhav V.</given-names></name><xref ref-type="aff" rid="af0018"><sup>18</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dranoff</surname><given-names>Glenn</given-names></name><xref ref-type="aff" rid="af0022"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Frazer</surname><given-names>Ian H.</given-names></name><xref ref-type="aff" rid="af0023"><sup>23</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fridman</surname><given-names>Wolf-Hervé</given-names></name><xref ref-type="aff" rid="af0024"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gabrilovich</surname><given-names>Dmitry I.</given-names></name><xref ref-type="aff" rid="af0025"><sup>25</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gilboa</surname><given-names>Eli</given-names></name><xref ref-type="aff" rid="af0026"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gnjatic</surname><given-names>Sacha</given-names></name><xref ref-type="aff" rid="af0027"><sup>27</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jäger</surname><given-names>Dirk</given-names></name><xref ref-type="aff" rid="af0028"><sup>28</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kalinski</surname><given-names>Pawel</given-names></name><xref ref-type="aff" rid="af0029"><sup>29</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kaufman</surname><given-names>Howard L.</given-names></name><xref ref-type="aff" rid="af0030"><sup>30</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kiessling</surname><given-names>Rolf</given-names></name><xref ref-type="aff" rid="af0031"><sup>31</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kirkwood</surname><given-names>John</given-names></name><xref ref-type="aff" rid="af0032"><sup>32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Knuth</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="af0033"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Liblau</surname><given-names>Roland</given-names></name><xref ref-type="aff" rid="af0034"><sup>34</sup></xref><xref ref-type="aff" rid="af0035"><sup>35</sup></xref><xref ref-type="aff" rid="af0036"><sup>36</sup></xref><xref ref-type="aff" rid="af0037"><sup>37</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lotze</surname><given-names>Michael T.</given-names></name><xref ref-type="aff" rid="af0038"><sup>38</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lugli</surname><given-names>Enrico</given-names></name><xref ref-type="aff" rid="af0039"><sup>39</sup></xref></contrib><contrib contrib-type="author"><name><surname>Marincola</surname><given-names>Francesco</given-names></name><xref ref-type="aff" rid="af0040"><sup>40</sup></xref></contrib><contrib contrib-type="author"><name><surname>Melero</surname><given-names>Ignacio</given-names></name><xref ref-type="aff" rid="af0041"><sup>41</sup></xref></contrib><contrib contrib-type="author"><name><surname>Melief</surname><given-names>Cornelis J.</given-names></name><xref ref-type="aff" rid="af0042"><sup>42</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mempel</surname><given-names>Thorsten R.</given-names></name><xref ref-type="aff" rid="af0043"><sup>43</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mittendorf</surname><given-names>Elizabeth A.</given-names></name><xref ref-type="aff" rid="af0044"><sup>44</sup></xref></contrib><contrib contrib-type="author"><name><surname>Odun</surname><given-names>Kunle</given-names></name><xref ref-type="aff" rid="af0045"><sup>45</sup></xref></contrib><contrib contrib-type="author"><name><surname>Overwijk</surname><given-names>Willem W.</given-names></name><xref ref-type="aff" rid="af0046"><sup>46</sup></xref></contrib><contrib contrib-type="author"><name><surname>Palucka</surname><given-names>Anna Karolina</given-names></name><xref ref-type="aff" rid="af0047"><sup>47</sup></xref></contrib><contrib contrib-type="author"><name><surname>Parmiani</surname><given-names>Giorgio</given-names></name><xref ref-type="aff" rid="af0048"><sup>48</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ribas</surname><given-names>Antoni</given-names></name><xref ref-type="aff" rid="af0020"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Romero</surname><given-names>Pedro</given-names></name><xref ref-type="aff" rid="af0021"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schreiber</surname><given-names>Robert D.</given-names></name><xref ref-type="aff" rid="af0049"><sup>49</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schuler</surname><given-names>Gerold</given-names></name><xref ref-type="aff" rid="af0050"><sup>50</sup></xref></contrib><contrib contrib-type="author"><name><surname>Srivastava</surname><given-names>Pramod K.</given-names></name><xref ref-type="aff" rid="af0051"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tartour</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="af0052"><sup>52</sup></xref></contrib><contrib contrib-type="author"><name><surname>Valmori</surname><given-names>Danila</given-names></name><xref ref-type="aff" rid="af0008"><sup>8</sup></xref><xref ref-type="aff" rid="af0053"><sup>53</sup></xref></contrib><contrib contrib-type="author"><name><surname>van der Burg</surname><given-names>Sjoerd H.</given-names></name><xref ref-type="aff" rid="af0054"><sup>54</sup></xref></contrib><contrib contrib-type="author"><name><surname>van der Bruggen</surname><given-names>Pierre</given-names></name><xref ref-type="aff" rid="af0055"><sup>55</sup></xref></contrib><contrib contrib-type="author"><name><surname>van den Eynde</surname><given-names>Benoît J.</given-names></name><xref ref-type="aff" rid="af0055"><sup>55</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Ena</given-names></name><xref ref-type="aff" rid="af0040"><sup>40</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zou</surname><given-names>Weiping</given-names></name><xref ref-type="aff" rid="af0056"><sup>56</sup></xref></contrib><contrib contrib-type="author"><name><surname>Whiteside</surname><given-names>Theresa L.</given-names></name><xref ref-type="aff" rid="af0057"><sup>57</sup></xref></contrib><contrib contrib-type="author"><name><surname>Speiser</surname><given-names>Daniel E.</given-names></name><xref ref-type="aff" rid="af0021"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pardoll</surname><given-names>Drew M.</given-names></name><xref ref-type="aff" rid="af0005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Restifo</surname><given-names>Nicholas P.</given-names></name><xref ref-type="aff" rid="af0058"><sup>58</sup></xref></contrib><contrib contrib-type="author"><name><surname>Anderson</surname><given-names>Ana C.</given-names></name><xref ref-type="aff" rid="af0059"><sup>59</sup></xref><xref ref-type="corresp" rid="an0001"><sup>*</sup></xref></contrib><aff id="af0001"><label>1</label><institution>INSERM; UMR 866</institution>, Dijon,<country>France</country></aff><aff id="af0002"><label>2</label><institution>Centre Georges François Leclerc</institution>, Dijon,<country>France</country></aff><aff id="af0003"><label>3</label><institution>Université de Bourgogne</institution>, Dijon,<country>France</country></aff><aff id="af0004"><label>4</label><institution>QIMR Berghofer Medical Research Institute</institution>, Herston, Queensland,<country>Australia</country></aff><aff id="af0005"><label>5</label><institution>Sidney Kimmel Comprehensive Cancer Center; Johns Hopkins University School of Medicine</institution>, Baltimore, MD,<country>USA</country></aff><aff id="af0006"><label>6</label><institution>Institut de Recherches Internationales Servier</institution>;<addr-line>53, rue Carnot</addr-line>, Suresnes,<country>France</country></aff><aff id="af0007"><label>7</label><institution>The Shraga Segal Department of Microbiology; Immunology and Genetics</institution>;<institution>The Faculty of Health Sciences, Ben Gurion University of the Negev</institution>, Beer Sheva,<country>Israel</country></aff><aff id="af0008"><label>8</label><institution>INSERM, Unité1102; Equipe Labellisée Ligue Contre le Cancer</institution>;<institution>Institut de Cancérologie de l’Ouest</institution>, Nantes-Saint Herblain;<country>France</country></aff><aff id="af0009"><label>9</label><institution>Cancer Research Center of Lyon; INSERM UMR 1052</institution>;<institution>CNRS UMR 5286</institution>, Centre Leon Berard, Lyon,<country>France</country></aff><aff id="af0010"><label>10</label><institution>Medical Oncology Department</institution>, Lyon,<country>France</country></aff><aff id="af0011"><label>11</label><institution>CRCNA, INSERM U892; CNRS UMR 6299</institution>, Nantes,<country>France</country></aff><aff id="af0012"><label>12</label><institution>Institut Mérieux</institution>, Lyon,<country>France</country></aff><aff id="af0013"><label>13</label><institution>University of Pittsburgh Cancer Institute, Departments of Medicine, Surgery, and Immunology</institution>, Pittsburgh, PA,<country>USA</country></aff><aff id="af0014"><label>14</label><institution>INSERM UMR 1116</institution>, Paris,<country>France</country></aff><aff id="af0015"><label>15</label><institution>Unit of Immunotherapy of Human Tumor; Department of Experimental Oncology and Molecular Medicine</institution>;<institution>Fondazione IRCCS Istituto Nazionale dei Tumori</institution>, Milan,<country>Italy</country></aff><aff id="af0016"><label>16</label><institution>Department of Molecular Biotechnology and Health Sciences; Molecular Biotechnology Center, University of Torino</institution>,<country>Italy</country></aff><aff id="af0017"><label>17</label><institution>Cancer Immunology; Inflammation and Tolerance Program; Georgia Regents University Cancer Center</institution>; Augusta, GA,<country>USA</country></aff><aff id="af0018"><label>18</label><institution>Department of Immunobiology and Yale Cancer Center; Yale University School of Medicine</institution>, New Haven, CT,<country>USA</country></aff><aff id="af0019"><label>19</label><institution>Molecular Immunology Unit; Department of Experimental Oncology and Molecular Medicine</institution>;<institution>Fondazione IRCCS Istituto Nazionale dei Tumori</institution>; Milan,<country>Italy</country></aff><aff id="af0020"><label>20</label><institution>UCLA School of Medicine</institution>;<institution>Jonsson Comprehensive Cancer Center Los Angeles</institution>, CA,<country>USA</country></aff><aff id="af0021"><label>21</label><institution>Ludwig Center for Cancer Research; Department of Oncology; University of Lausanne</institution>,<country>Switzerland</country></aff><aff id="af0022"><label>22</label><institution>Department of Medical Oncology and Cancer Vaccine Center; Dana-Farber Cancer Institute and Department of Medicine</institution>;<institution>Brigham and Women's Hospital and Harvard Medical School</institution>, Boston, MA,<country>USA</country></aff><aff id="af0023"><label>23</label><institution>The University of Queensland</institution>, Queensland,<country>Australia</country></aff><aff id="af0024"><label>24</label><institution>Cordeliers Research Centre, University of Paris-Descartes</institution>, Paris,<country>France</country></aff><aff id="af0025"><label>25</label><institution>Translational Tumor Immunology; The Wistar Institute</institution>, Philadelphia, PA,<country>USA</country></aff><aff id="af0026"><label>26</label><institution>Department of Microbiology & Immunology; Dodson Interdisciplinary Immunotherapy Institute</institution>;<institution>Sylvester Comprehensive Cancer Center; Miller School of Medicine</institution>;<institution>University of Miami</institution>, Miami, FL,<country>USA</country></aff><aff id="af0027"><label>27</label><institution>Tisch Cancer Institute; Icahn School of Medicine at Mount Sinai</institution>, New York, NY,<country>USA</country></aff><aff id="af0028"><label>28</label><institution>Department of Medical Oncology; National Center for Tumor Diseases</institution>;<institution>Internal Medicine VI; Heidelberg University Hospital</institution>, Heidelberg,<country>Germany</country></aff><aff id="af0029"><label>29</label><institution>Department of Surgery; University of Pittsburgh</institution>; Pittsburgh, PA,<country>USA</country></aff><aff id="af0030"><label>30</label><institution>Rutgers Cancer Institute of New Jersey</institution>, New Brunswick, NJ,<country>USA</country></aff><aff id="af0031"><label>31</label><institution>Department of Oncology/Pathology; Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></aff><aff id="af0032"><label>32</label><institution>Division of Hematology/Oncology; Department of Medicine</institution>;<institution>School of Medicine; University of Pittsburgh</institution>, Pittsburgh; PA;<country>USA</country>;<institution>Melanoma and Skin Cancer Program; University of Pittsburgh Cancer Institute</institution>, Pittsburgh, PA,<country>USA</country></aff><aff id="af0033"><label>33</label><institution>National Center for Cancer Care & Research</institution>, Doha,<country>Qatar</country></aff><aff id="af0034"><label>34</label><institution>INSERM-UMR 1043</institution>; Toulouse,<country>France</country></aff><aff id="af0035"><label>35</label><institution>CNRS</institution>;<addr-line>U5282</addr-line>, Toulouse,<country>France</country></aff><aff id="af0036"><label>36</label><institution>Universite de Toulouse; UPS</institution>;<institution>Centre de Physiopathologie Toulouse Purpan (CPTP)</institution>; Toulouse,<country>France</country></aff><aff id="af0037"><label>37</label><institution>CHU Toulouse Purpan</institution>; Toulouse,<country>France</country></aff><aff id="af0038"><label>38</label><institution>Hillman Cancer Center; University of Pittsburgh Schools of Health Sciences</institution>, Pittsburgh, PA,<country>USA</country></aff><aff id="af0039"><label>39</label><institution>Unit of Clinical and Experimental Immunology; Humanitas Clinical and Research Center</institution>, Rozzano,<country>Italy</country></aff><aff id="af0040"><label>40</label><institution>Research Branch; Sidra Medical and Research Centre</institution>, Doha,<country>Qatar</country></aff><aff id="af0041"><label>41</label><institution>Division of Oncology; Center for Applied Medical Research and Clinica Universidad de Navarra</institution>, Pamploma,<country>Spain</country></aff><aff id="af0042"><label>42</label><institution>Leiden University; ISA Pharmaceuticals</institution>,<country>Netherlands</country></aff><aff id="af0043"><label>43</label><institution>Center for Immunology and Inflammatory Diseases; Massachusetts General Hospital</institution>;<institution>Harvard Medical School</institution>, Boston, MA,<country>USA</country></aff><aff id="af0044"><label>44</label><institution>Deparment of Surgical Oncology; University of Texas MD Anderson Cancer Center</institution>, Houston, TX,<country>USA</country></aff><aff id="af0045"><label>45</label><institution>Departments of Gynecologic Oncology and Immunology; Roswell Park Cancer Institute</institution>, Buffalo, NY,<country>USA</country></aff><aff id="af0046"><label>46</label><institution>Department of Melanoma Medical Oncology; University of Texas MD Anderson Cancer Center</institution>, Houston, TX,<country>USA</country></aff><aff id="af0047"><label>47</label><institution>The Jackson Laboratory for Genomic Medicine</institution>, Farmington, CT,<country>USA</country></aff><aff id="af0048"><label>48</label><institution>Division of Medical Oncology and Immunotherapy; University Hospital</institution>, Siena,<country>Italy</country></aff><aff id="af0049"><label>49</label><institution>Department of Pathology and Immunology; Washington University School of Medicine</institution>, St. Louis, MO<country>USA</country></aff><aff id="af0050"><label>50</label><institution>Department of Dermatology; Universitatsklinikum Erlangen</institution>, Erlangen,<country>Germany</country></aff><aff id="af0051"><label>51</label><institution>Center for Immunotherapy of Cancer and Infectious Diseases; Carole and Ray Neag Comprehensive Cancer Center</institution>;<institution>University of Connecticut Health Center</institution>, Farmington, CT,<country>USA</country></aff><aff id="af0052"><label>52</label><institution>Department of Clinical Oncology, INSERM U970; Universite Paris Descartes</institution>;<institution>Sorbonne Paris-Cité; Paris</institution>;<institution>France; Hôpital Européen Georges Pompidou</institution>;<institution>Service d’Immunologie Biologique</institution>; Paris,<country>France</country></aff><aff id="af0053"><label>53</label><institution>Faculty of Medicine, University of Nantes, 44035 Nantes, France</institution></aff><aff id="af0054"><label>54</label><institution>Leiden University Medical Center</institution>, Leiden,<country>Netherlands</country></aff><aff id="af0055"><label>55</label><institution>Ludwig Institute for Cancer Research; BrusselsBranch de Duve Institute</institution>;<institution>Université Catholique de Louvain</institution>, Brussels,<country>Blegium</country></aff><aff id="af0056"><label>56</label><institution>Department of Surgery; University of Michigan School of Medicine</institution>,<institution>Ann Arbor</institution>, MI,<country>USA</country></aff><aff id="af0057"><label>57</label><institution>Department of Pathology; Immunology, and Otolaryngology</institution>;<institution>University of Pittsburgh Cancer Institute</institution>, Pittsburgh, PA,<country>USA</country></aff><aff id="af0058"><label>58</label><institution>National Cancer Institute; National Institutes of Health</institution>, Bethesda, MD,<country>USA</country></aff><aff id="af0059"><label>59</label><institution>Evergrande Center for Immunologic Diseases; Ann Romney Center for Neurologic Diseases</institution>;<institution>Brigham and Women's Hospital and Harvard Medical School</institution>, Boston, MA<country>USA</country></aff></contrib-group><author-notes><corresp id="an0001"><label>*</label>Correspondence to: Ana C. Anderson; Email: <email xlink:href="acanderson@partners.org">acanderson@partners.org</email>; Lionel Apetoh; Email: <email xlink:href="lionel.apetoh@inserm.fr">lionel.apetoh@inserm.fr</email></corresp></author-notes><pub-date pub-type="epub"><day>25</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="collection"><month>4</month><year>2015</year></pub-date><volume>4</volume><issue>4</issue><elocation-id seq="5">e998538</elocation-id><history><date date-type="received"><day>9</day><month>12</month><year>2014</year></date><date date-type="accepted"><day>10</day><month>12</month><year>2014</year></date></history><permissions><copyright-statement>© 2015 Taylor & Francis Group, LLC</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Taylor & Francis Group, LLC</copyright-holder></permissions><self-uri content-type="pdf" xlink:href="koni-04-04-998538.pdf"></self-uri><abstract><p>Whereas preclinical investigations and clinical studies have established that CD8<sup>+</sup> T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8<sup>+</sup> T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8<sup>+</sup> T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8<sup>+</sup> T cell immunity, leading to the emergence of dysfunctional CD8<sup>+</sup> T cells. The existence of different types of CD8<sup>+</sup> T cells in cancer calls for a more precise definition of the CD8<sup>+</sup> T cell immune phenotypes in cancer and the abandonment of the generic terms “pro-tumor” and “antitumor.” Based on recent studies investigating the functions of CD8<sup>+</sup> T cells in cancer, we here propose some guidelines to precisely define the functional states of CD8<sup>+</sup> T cells in cancer.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords</title><kwd>anergy</kwd><kwd>anticancer immunity</kwd><kwd>CD8<sup>+</sup> T cells</kwd><kwd>cytotoxicity</kwd><kwd>exhaustion</kwd><kwd>effector</kwd><kwd>IFNγ</kwd><kwd>senescence</kwd><kwd>stemness</kwd></kwd-group><counts><fig-count count="2"></fig-count><table-count count="0"></table-count><ref-count count="98"></ref-count><page-count count="10"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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