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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Optimal achieved blood pressure in acute intracerebral hemorrhage</title><author><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name></author><author><name sortKey="Heeley, Emma" sort="Heeley, Emma" uniqKey="Heeley E" first="Emma" last="Heeley">Emma Heeley</name></author><author><name sortKey="Delcourt, Candice" sort="Delcourt, Candice" uniqKey="Delcourt C" first="Candice" last="Delcourt">Candice Delcourt</name></author><author><name sortKey="Hirakawa, Yoichiro" sort="Hirakawa, Yoichiro" uniqKey="Hirakawa Y" first="Yoichiro" last="Hirakawa">Yoichiro Hirakawa</name></author><author><name sortKey="Wang, Xia" sort="Wang, Xia" uniqKey="Wang X" first="Xia" last="Wang">Xia Wang</name></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></author><author><name sortKey="Robinson, Thompson" sort="Robinson, Thompson" uniqKey="Robinson T" first="Thompson" last="Robinson">Thompson Robinson</name></author><author><name sortKey="Stapf, Christian" sort="Stapf, Christian" uniqKey="Stapf C" first="Christian" last="Stapf">Christian Stapf</name></author><author><name sortKey="Parsons, Mark" sort="Parsons, Mark" uniqKey="Parsons M" first="Mark" last="Parsons">Mark Parsons</name></author><author><name sortKey="Lavados, Pablo M" sort="Lavados, Pablo M" uniqKey="Lavados P" first="Pablo M." last="Lavados">Pablo M. Lavados</name></author><author><name sortKey="Huang, Yining" sort="Huang, Yining" uniqKey="Huang Y" first="Yining" last="Huang">Yining Huang</name></author><author><name sortKey="Wang, Jiguang" sort="Wang, Jiguang" uniqKey="Wang J" first="Jiguang" last="Wang">Jiguang Wang</name></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name></author><author><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S." last="Anderson">Craig S. Anderson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25552575</idno><idno type="pmc">4336065</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336065</idno><idno type="RBID">PMC:4336065</idno><idno type="doi">10.1212/WNL.0000000000001205</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000212</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000212</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Optimal achieved blood pressure in acute intracerebral hemorrhage</title><author><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name></author><author><name sortKey="Heeley, Emma" sort="Heeley, Emma" uniqKey="Heeley E" first="Emma" last="Heeley">Emma Heeley</name></author><author><name sortKey="Delcourt, Candice" sort="Delcourt, Candice" uniqKey="Delcourt C" first="Candice" last="Delcourt">Candice Delcourt</name></author><author><name sortKey="Hirakawa, Yoichiro" sort="Hirakawa, Yoichiro" uniqKey="Hirakawa Y" first="Yoichiro" last="Hirakawa">Yoichiro Hirakawa</name></author><author><name sortKey="Wang, Xia" sort="Wang, Xia" uniqKey="Wang X" first="Xia" last="Wang">Xia Wang</name></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></author><author><name sortKey="Robinson, Thompson" sort="Robinson, Thompson" uniqKey="Robinson T" first="Thompson" last="Robinson">Thompson Robinson</name></author><author><name sortKey="Stapf, Christian" sort="Stapf, Christian" uniqKey="Stapf C" first="Christian" last="Stapf">Christian Stapf</name></author><author><name sortKey="Parsons, Mark" sort="Parsons, Mark" uniqKey="Parsons M" first="Mark" last="Parsons">Mark Parsons</name></author><author><name sortKey="Lavados, Pablo M" sort="Lavados, Pablo M" uniqKey="Lavados P" first="Pablo M." last="Lavados">Pablo M. Lavados</name></author><author><name sortKey="Huang, Yining" sort="Huang, Yining" uniqKey="Huang Y" first="Yining" last="Huang">Yining Huang</name></author><author><name sortKey="Wang, Jiguang" sort="Wang, Jiguang" uniqKey="Wang J" first="Jiguang" last="Wang">Jiguang Wang</name></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name></author><author><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S." last="Anderson">Craig S. Anderson</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><idno type="eISSN">1526-632X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives:</title><p>To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH).</p></sec><sec><title>Methods:</title><p>INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 patients with ICH within 6 hours of onset and elevated systolic BP (SBP) (150–220 mm Hg) who were allocated to receive intensive (target SBP <140 mm Hg within 1 hour, with lower limit of 130 mm Hg for treatment cessation) or guideline-recommended (target SBP <180 mm Hg) BP-lowering treatment. Outcome was physical function across all 7 levels of the modified Rankin Scale at 90 days.</p></sec><sec><title>Results:</title><p>Analysis of the randomized comparisons showed that intensive BP lowering produced comparable benefits on physical function at 90 days in 5 subgroups defined by baseline SBP of <160, 160–169, 170–179, 180–189, and ≥190 mm Hg (<italic>p</italic> homogeneity = 0.790). Analyses of achieved BP showed linear increases in the risk of physical dysfunction for achieved SBP above 130 mm Hg for both hyperacute (1–24 hours) and acute (2–7 days) phases while modest increases were also observed for achieved SBP below 130 mm Hg.</p></sec><sec><title>Conclusions:</title><p>Intensive BP lowering appears beneficial across a wide range of baseline SBP levels, and target SBP level of 130–139 mm Hg is likely to provide maximum benefit in acute ICH.</p></sec><sec><title>Classification of evidence:</title><p>This study provides Class I evidence that the effect of intensive BP lowering on physical function is not influenced by baseline BP.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neurology</journal-id><journal-id journal-id-type="iso-abbrev">Neurology</journal-id><journal-id journal-id-type="hwp">neurology</journal-id><journal-id journal-id-type="publisher-id">neur</journal-id><journal-id journal-id-type="pmc">neurology</journal-id><journal-id journal-id-type="publisher-id">NEUROLOGY</journal-id><journal-title-group><journal-title>Neurology</journal-title></journal-title-group><issn pub-type="ppub">0028-3878</issn><issn pub-type="epub">1526-632X</issn><publisher><publisher-name>Lippincott Williams & Wilkins</publisher-name><publisher-loc>Hagerstown, MD</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25552575</article-id><article-id pub-id-type="pmc">4336065</article-id><article-id pub-id-type="publisher-id">NEUROLOGY2014588087</article-id><article-id pub-id-type="doi">10.1212/WNL.0000000000001205</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>7</subject><subject>20</subject></subj-group><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Optimal achieved blood pressure in acute intracerebral hemorrhage</article-title><subtitle>INTERACT2</subtitle></title-group><contrib-group><contrib contrib-type="author"><name><surname>Arima</surname><given-names>Hisatomi</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>(1) Journal of Hypertension, Editorial Board Member, 1 year, (2) BMC Public Health, Associate Editor, 3 years</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>Takeda Pharmaceutical Company</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NHMRC Project Grant, 1020462, Chief Investigator, 2012- 2016 ARC Future Fellowship, FT100100928, Fellow, 2011-2014 NHMRC Project Grant, 1004170, Chief Investigator, 2011- 2013 NHMRC Project Grant, 1006501, Chief Investigator, 2011- 2015 NHMRC Project Grant, 632758, Chief Investigator, 2010-2012</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Heeley</surname><given-names>Emma</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for travel or speaker honoraria:</title><list-item><p>EH received AUD$4000 as a travel grant from Servier Laboratories to attend the European Stroke Conference 2009.</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Delcourt</surname><given-names>Candice</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Hirakawa</surname><given-names>Yoichiro</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Xia</given-names></name><degrees>MMed</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Woodward</surname><given-names>Mark</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>(1) Novartis (2) Roche (3) Sanofi</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for travel or speaker honoraria:</title><list-item><p>(1) Roche</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>(1) Statistics in Medicine, Ass Ed, 2006-14 (2) Global Health, Ass Ed, 2011-3 (3) Women's Health, Ed, 2008-14</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>(1) National Health and Medical Research Council (2) NIH (3) NIOSH</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>(1) University of Oxford (2) Johns Hopkins University (3) Mount Sinai School of Medicine, NYC</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>(1) Bernstein Litowitz Berger & Grossmann LLP, Represented the plaintiff in Vioxx litigation, 2012-3</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Robinson</surname><given-names>Thompson</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>Commercial (Daiichi Sankyo), Advisory Board. Commercial (Boehringer Ingelheim), Advisory Board.</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Age and Ageing, Associate Editor, 2003 to date</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>Research Council (EPSRC) 2013 (3 Years, Principal Applicant); Diversity in blood flow control of the brain: moving from individual modelling towards personalised treatment of the injured brain (?320,853) NIHR Health Technology Assessment Programme Clinical Trials 2012 (5 years, Co-applicant); Safety and Efficacy of Triple Antiplatelets for Reducing Dependency After Ischaemic Stroke: the TARDIS Randomied Controlled Trial (?3,291,971) NIHR Health Technology Assessment Programme Clinical Trials 2012 (4 years, Co-applicant); Tranexamic acid for hyperacute primary Intracerebral Haemorrhage, TICH-2 (?2,889,221) NIHR Programme Grant 2012 (5 years, Co-Applicant): Bridging the age gap in breast cancer. Improving outcomes for older women. (?1,705,273)</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>Stroke Association/British Heart Foundation Programme Grant 2012 (5 years, Principal Applicant); Blood Pressure Variability ? Definition, Natural History, Prognosis and Treatment Following Acute Stroke (?878,190) The Stroke Association 2012 (3 years, Principal Applicant); Enhanced Control of Hypertension and Thrombolysis Stroke Trial, ENCHANTED (?202,319) British Heart Foundation 2010 (3 years, Co-applicant); Intermediate Basic Science Research Fellowship: Forecasting brain injury in the virtual patient (?259,268) Stroke Association 2009 (2 years, Principal Applicant); Project Grant: MRI Assessment of Post-Stroke Focal Versus Global Cerebrovascular Autoregulation (?102,332) British Heart Foundation 2008 (3 years, Co-applicant); Project Grant: Safety and tolerability of adding clopidogrel to aspirin and dipyridamole in patients with acute ischaemic stroke or TIA: a randomised controlled trial (?318,932)</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Stapf</surname><given-names>Christian</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NIH/NINDS, NS051483-01A1, co-PI, 2006-2014</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>(1) Columbia University New York, USA; (2) University Paris Diderot - Sorbonne Paris Cit?, France</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Parsons</surname><given-names>Mark</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>International Journal of Stroke, Editorial Board</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>Australia Researc Council Future Fellowship Number FT0991128</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>Vice President Stroke Society of Australasia</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Lavados</surname><given-names>Pablo M.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>1. Sanofi-Aventis: Serves on the advisory board of the OPTIC Study funded by Sanofi-Aventis 2. Bristol Meyers Squib: Has served on advisory board in atrial fibrilation for BMS</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for travel or speaker honoraria:</title><list-item><p>1. Bayer: Received travel grant by Bayer 2. Boehringer Ingelheim: Received travel grant by Boehringer Ingelheim. 3. Received speaker honoraria from Bristol Meyers Squib 4. Received speaker honoraria from Bayer</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>1. Clinica Alemana-Universidad del Desarrollo: Receives institutional support from Clinica Alemana-Universidad del Desarrollo to perform stroke administration and research.</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>1. Bristol Meyers Squib: Has served as speaker for BMS</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>1. Lundbeck: Receives research funding from Lundbeck 2. Astra Zeneca: Serves as national coordinator of SOCRATES study and receives research funding for this. 3. Bayer: Receives research support from Bayer.</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>1. Clinica Alemana-Universiad del Desarrollo: Receives academic research support from Cl?nica Alemana for the HEADPOST studies. 2. The George Institute for Global Health. Receives academic research support from TGI for the INTERACT2, ENCHANTED and HEADPOST studies.</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Yining</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Jiguang</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for travel or speaker honoraria:</title><list-item><p>(1) Boehringer Ingelheim (2) MSD (3)Novartis (4) Omron (5) Pfizer (6) Sankyo (7) Sanofi (8) Servier (9) Takeda</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>(1) Chinese Journal of Hypertension, Deputy Editor, 2007- present (2) Hypertension Research, Associate Editor, 2010- present (3) Hypertension, Associate Editor, 2013-present (4) Pulse, Co-Editor, 2014-present</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>Omron, Principal Investigator, 2008-2010 Pfizer, Principal Investigator, 2008-2010</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>The National Natural Science Foundation of China, 30871360, 2008-2010 81170245, 2012-2015 Chinese Ministry of Science and Technology, 2013CB530700, 2013-2017 1012 (A grant for the China-European Union collaborations), 2011-2013 The Shanghai Bureau of Health and Family Planning, XBR2011004, 2011-2015</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Chalmers</surname><given-names>John</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for travel or speaker honoraria:</title><list-item><p>Research grants from Servier for the ADVANCE-ON post trial follow-up study and, and honoraria and travel support from Servier, for speaking about the ADVANCE and ADVANCE-ON studies at Scientific meetings</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Associate Editor for the Journal of Hypertension, from 2011</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>Servier: provided Researh grants to me as Co-Principal Investigator for PROGRESS (1994 to 2001), ADVANCE (2001 to 2008) and ADVANCE-ON (2010-2013), administered through the University of Sydney: Role--Principal Investigator: years 1995-todate.</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>The National Health and Medical Research Council of Australia has awarded me two project grants (1) as Co- Chief Investigator for INTERACT2 for 2008-2011 : Grant number 512402:2008-2011, and (2) as Co-Chief Investigator for ENCHANTED for 2012-17 : Grant Number APP1020462.</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Anderson</surname><given-names>Craig S.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>Pfizer</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for travel or speaker honoraria:</title><list-item><p>Pfizer, Takeda China</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Stroke, Cerebrovascular Diseases, Medical Journal of Australia</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>Program grant (1052555), Project grant (1020462) and Fellowship (1081356) support from the National Health and Medical Research Council (NHMRC) of Australia.</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><aff>From The George Institute for Global Health (H.A., E.H., C.D., Y.H., X.W., M.W., J.C., C.S.A.), University of Sydney and Royal Prince Alfred Hospital, Sydney, Australia; Department of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Disease (T.R.), University of Leicester, UK; Department of Neurology (C.S.), APHP, Hôpital Lariboisière and DHU NeuroVasc Paris, Sorbonne, Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Department of Neurology (M.P.), John Hunter Hospital, University of Newcastle, Australia; Servicio de Neurología (P.M.L.), Departamento de Medicina, Clínica Alemana, Universidad del Desarrollo, Santiago; Departamento de Ciencias Neurológicas (P.M.L.), Universidad de Chile, Santiago; Department of Neurology (Y.H.), Peking University First Hospital, Beijing; and The Shanghai Institute of Hypertension (J.W.), Rui Jin Hospital, Shanghai Jiaotong University, Shanghai, China.</aff></contrib-group><contrib-group><contrib contrib-type="author"><collab>For the INTERACT2 Investigators</collab></contrib></contrib-group><contrib-group><contrib contrib-type="collab"><name><surname>Anderson</surname><given-names>C.S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Chalmers</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Arima</surname><given-names>H.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Davis</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Heeley</surname><given-names>E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Huang</surname><given-names>Y.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Lavados</surname><given-names>P.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Neal</surname><given-names>B.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Parsons</surname><given-names>M.W.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Lindley</surname><given-names>R.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Morgenstern</surname><given-names>L.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Robinson</surname><given-names>T.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Stapf</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Tzourio</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Wang</surname><given-names>J.G.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Huang</surname><given-names>Y.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Chen</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Chen</surname><given-names>X.Y.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Cui</surname><given-names>L.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Liu</surname><given-names>Z.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Lu</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Wang</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Wu</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Xu</surname><given-names>E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Yang</surname><given-names>Q.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Zhang</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Zhang</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Beer</surname><given-names>R.</given-names></name></contrib><contrib 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contrib-type="collab"><name><surname>Estol</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Silva</surname><given-names>G.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Lavados</surname><given-names>P.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Olavarria</surname><given-names>V.V.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Robinson</surname><given-names>T.G.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Simes</surname><given-names>R.J.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Bousser</surname><given-names>M.-G.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Hankey</surname><given-names>G.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Jamrozik</surname><given-names>K.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Johnston</surname><given-names>S.C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Li</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Heeley</surname><given-names>E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Anderson</surname><given-names>C.S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Bailey</surname><given-names>K.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Chalmers</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Cheung</surname><given-names>T.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Delcourt</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Chintapatla</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Ducasse</surname><given-names>E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Erho</surname><given-names>T.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Hata</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Holder</surname><given-names>B.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Knight</surname><given-names>E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Lindley</surname><given-names>R.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Leroux</surname><given-names>M.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Sassé</surname><given-names>T.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Odgers</surname><given-names>E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Walsh</surname><given-names>R.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Wolfowicz</surname><given-names>Z.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Anderson</surname><given-names>C.S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Chen</surname><given-names>G.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Delcourt</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Fuentes</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Lindley</surname><given-names>R.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Peng</surname><given-names>B.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Schneble</surname><given-names>H.-M.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Wang</surname><given-names>M.-X.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Arima</surname><given-names>H.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Billot</surname><given-names>L.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Heritier</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Li</surname><given-names>Q.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Woodward</surname><given-names>M.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Delcourt</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Abimbola</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Anderson</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Chan</surname><given-names>E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Cheng</surname><given-names>G.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Chmielnik</surname><given-names>P.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Hata</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Leighton</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Liu</surname><given-names>J.-Y.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Rasmussen</surname><given-names>B.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Saxena</surname><given-names>A.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Tripathy</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Armenis</surname><given-names>M.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Baig</surname><given-names>M.A.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Naidu</surname><given-names>B.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Starzec</surname><given-names>G.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Steley</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Anderson</surname><given-names>C.S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Heeley</surname><given-names>E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Leroux</surname><given-names>M.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Delcourt</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Sassé</surname><given-names>T.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Knight</surname><given-names>E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Bailey</surname><given-names>K.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Cheung</surname><given-names>T.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Odgers</surname><given-names>E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Ducasse</surname><given-names>E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Holder</surname><given-names>B.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Wolfowicz</surname><given-names>Z.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Walsh</surname><given-names>R.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Chintapatla</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Erho</surname><given-names>T.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Estol</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Moles</surname><given-names>A.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Ruiz</surname><given-names>A.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Zimmermann</surname><given-names>M.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Marinho</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Alves</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Angelim</surname><given-names>R.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Araujo</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Kawakami</surname><given-names>L.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Lavados</surname><given-names>P.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Olavarria</surname><given-names>V.V.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Bustos</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Gonzalez</surname><given-names>F.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Venturelli</surname><given-names>P. Munoz</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Huang</surname><given-names>Y.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Chen</surname><given-names>X.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Huang</surname><given-names>Y.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Jia</surname><given-names>R.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Li</surname><given-names>N.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Qu</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Shu</surname><given-names>Y.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Song</surname><given-names>A.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Sun</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Xiao</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Zhao</surname><given-names>Y.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Wang</surname><given-names>J.-G.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Huang</surname><given-names>Q.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Stapf</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Vicaut</surname><given-names>E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Chamam</surname><given-names>A.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Viaud</surname><given-names>M.-C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Dert</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Fiedler</surname><given-names>U.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Jovis</surname><given-names>V.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Kabla</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Marchand</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Pena</surname><given-names>A.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Rochaud</surname><given-names>V.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Mallikarjuna</surname><given-names>K.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Boyini</surname><given-names>H.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Hasan</surname><given-names>N.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Berge</surname><given-names>E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Sandset</surname><given-names>E.C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Forårsveen</surname><given-names>A. 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contrib-type="collab"><name><surname>Roffe</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Natarajan</surname><given-names>I.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Ahmad</surname><given-names>N.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Finney</surname><given-names>K.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Lucas</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Mistri</surname><given-names>A.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Eveson</surname><given-names>D.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Marsh</surname><given-names>R.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Haunton</surname><given-names>V.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Robinson</surname><given-names>T.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Rabinstein</surname><given-names>A.A.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Fugate</surname><given-names>J.E.</given-names></name></contrib><contrib contrib-type="collab"><name><surname>Lepore</surname><given-names>S.W.</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Prof. Anderson: <email>canderson@georgeinstitute.org.au</email></corresp><fn fn-type="other"><p>INTERACT2 coinvestigators are listed on the <italic>Neurology</italic>® Web site at <ext-link ext-link-type="uri" xlink:href="http://Neurology.org">Neurology.org</ext-link>.</p></fn><fn fn-type="financial-disclosure"><p>Go to <ext-link ext-link-type="uri" xlink:href="http://neurology.org/">Neurology.org</ext-link> for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.</p></fn></author-notes><pub-date pub-type="ppub"><day>3</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>3</day><month>2</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>84</volume><issue>5</issue><fpage>464</fpage><lpage>471</lpage><history><date date-type="received"><day>04</day><month>4</month><year>2014</year></date><date date-type="accepted"><day>04</day><month>9</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 American Academy of Neurology</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>American Academy of Neurology</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="NEUROLOGY2014588087.pdf"></self-uri><abstract><sec><title>Objectives:</title><p>To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH).</p></sec><sec><title>Methods:</title><p>INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 patients with ICH within 6 hours of onset and elevated systolic BP (SBP) (150–220 mm Hg) who were allocated to receive intensive (target SBP <140 mm Hg within 1 hour, with lower limit of 130 mm Hg for treatment cessation) or guideline-recommended (target SBP <180 mm Hg) BP-lowering treatment. Outcome was physical function across all 7 levels of the modified Rankin Scale at 90 days.</p></sec><sec><title>Results:</title><p>Analysis of the randomized comparisons showed that intensive BP lowering produced comparable benefits on physical function at 90 days in 5 subgroups defined by baseline SBP of <160, 160–169, 170–179, 180–189, and ≥190 mm Hg (<italic>p</italic> homogeneity = 0.790). Analyses of achieved BP showed linear increases in the risk of physical dysfunction for achieved SBP above 130 mm Hg for both hyperacute (1–24 hours) and acute (2–7 days) phases while modest increases were also observed for achieved SBP below 130 mm Hg.</p></sec><sec><title>Conclusions:</title><p>Intensive BP lowering appears beneficial across a wide range of baseline SBP levels, and target SBP level of 130–139 mm Hg is likely to provide maximum benefit in acute ICH.</p></sec><sec><title>Classification of evidence:</title><p>This study provides Class I evidence that the effect of intensive BP lowering on physical function is not influenced by baseline BP.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>special-property</meta-name><meta-value>podcast</meta-value></custom-meta><custom-meta><meta-name>special-property</meta-name><meta-value>triangle</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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