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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization</title><author><name sortKey="Zhang, Ben" sort="Zhang, Ben" uniqKey="Zhang B" first="Ben" last="Zhang">Ben Zhang</name></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name></author><author><name sortKey="Delahanty, Ryan J" sort="Delahanty, Ryan J" uniqKey="Delahanty R" first="Ryan J." last="Delahanty">Ryan J. Delahanty</name></author><author><name sortKey="Zeng, Chenjie" sort="Zeng, Chenjie" uniqKey="Zeng C" first="Chenjie" last="Zeng">Chenjie Zeng</name></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name></author><author><name sortKey="Wen, Wanqing" sort="Wen, Wanqing" uniqKey="Wen W" first="Wanqing" last="Wen">Wanqing Wen</name></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name></author><author><name sortKey="Li, Chun" sort="Li, Chun" uniqKey="Li C" first="Chun" last="Li">Chun Li</name></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name></author><author><name sortKey="Perkins, Barbara J" sort="Perkins, Barbara J" uniqKey="Perkins B" first="Barbara J." last="Perkins">Barbara J. Perkins</name></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A." last="Rookus">Matti A. Rookus</name></author><author><name sortKey="Van Den Hurk, Katja" sort="Van Den Hurk, Katja" uniqKey="Van Den Hurk K" first="Katja" last="Van Den Hurk">Katja Van Den Hurk</name></author><author><name sortKey="De Kort, Wim L A M" sort="De Kort, Wim L A M" uniqKey="De Kort W" first="Wim L. A. M." last="De Kort">Wim L. A. M. De Kort</name></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name></author><author><name sortKey="Hallberg, Emily" sort="Hallberg, Emily" uniqKey="Hallberg E" first="Emily" last="Hallberg">Emily Hallberg</name></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name></author><author><name sortKey="Brand, Judith" sort="Brand, Judith" uniqKey="Brand J" first="Judith" last="Brand">Judith Brand</name></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name></author><author><name sortKey="Cordina Duverger, Emilie" sort="Cordina Duverger, Emilie" uniqKey="Cordina Duverger E" first="Emilie" last="Cordina-Duverger">Emilie Cordina-Duverger</name></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name></author><author><name sortKey="Yang, Rongxi" sort="Yang, Rongxi" uniqKey="Yang R" first="Rongxi" last="Yang">Rongxi Yang</name></author><author><name sortKey="Surowy, Harald" sort="Surowy, Harald" uniqKey="Surowy H" first="Harald" last="Surowy">Harald Surowy</name></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name></author><author><name sortKey="Perez, Jose I A" sort="Perez, Jose I A" uniqKey="Perez J" first="Jose I. A." last="Perez">Jose I. A. Perez</name></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name></author><author><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loic Le" last="Marchand">Loic Le Marchand</name></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name></author><author><name sortKey="Tilanus Linthorst, Madeleine M A" sort="Tilanus Linthorst, Madeleine M A" uniqKey="Tilanus Linthorst M" first="Madeleine M. A." last="Tilanus-Linthorst">Madeleine M. A. Tilanus-Linthorst</name></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collée">J. Margriet Collée</name></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name></author><author><name sortKey="Haeberle, Lothar" sort="Haeberle, Lothar" uniqKey="Haeberle L" first="Lothar" last="Haeberle">Lothar Haeberle</name></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name></author><author><name sortKey="Swerdlow, Anthony J" sort="Swerdlow, Anthony J" uniqKey="Swerdlow A" first="Anthony J." last="Swerdlow">Anthony J. Swerdlow</name></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name></author><author><name sortKey="Antonenkova, Natalia" sort="Antonenkova, Natalia" uniqKey="Antonenkova N" first="Natalia" last="Antonenkova">Natalia Antonenkova</name></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name></author><author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name></author><author><name sortKey="Lubi Ski, Jan" sort="Lubi Ski, Jan" uniqKey="Lubi Ski J" first="Jan" last="Lubi Ski">Jan Lubi Ski</name></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name></author><author><name sortKey="Kristensen, Vessela N" sort="Kristensen, Vessela N" uniqKey="Kristensen V" first="Vessela N." last="Kristensen">Vessela N. Kristensen</name></author><author><name sortKey="Grenaker Aln S, Grethe I" sort="Grenaker Aln S, Grethe I" uniqKey="Grenaker Aln S G" first="Grethe I." last="Grenaker Aln S">Grethe I. Grenaker Aln S</name></author><author><name sortKey="Pierce, Brandon L" sort="Pierce, Brandon L" uniqKey="Pierce B" first="Brandon L." last="Pierce">Brandon L. Pierce</name></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name></author><author><name sortKey="Burgess, Stephen" sort="Burgess, Stephen" uniqKey="Burgess S" first="Stephen" last="Burgess">Stephen Burgess</name></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name></author><author><name sortKey="Gammon, Marilie D" sort="Gammon, Marilie D" uniqKey="Gammon M" first="Marilie D." last="Gammon">Marilie D. Gammon</name></author><author><name sortKey="Malone, Kathleen E" sort="Malone, Kathleen E" uniqKey="Malone K" first="Kathleen E." last="Malone">Kathleen E. Malone</name></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="Francois" last="Bacot">Francois Bacot</name></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name></author><author><name sortKey="Maranian, Mel" sort="Maranian, Mel" uniqKey="Maranian M" first="Mel" last="Maranian">Mel Maranian</name></author><author><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S." last="Healey">Catherine S. Healey</name></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name></author><author><name sortKey="Pita, Guillermo" sort="Pita, Guillermo" uniqKey="Pita G" first="Guillermo" last="Pita">Guillermo Pita</name></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M. Rosario" last="Alonso">M. Rosario Alonso</name></author><author><name sortKey="Alvarez, Nuria" sort="Alvarez, Nuria" uniqKey="Alvarez N" first="Nuria" last="Álvarez">Nuria Álvarez</name></author><author><name sortKey="Herrero, Daniel" sort="Herrero, Daniel" uniqKey="Herrero D" first="Daniel" last="Herrero">Daniel Herrero</name></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26296642</idno><idno type="pmc">4643630</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643630</idno><idno type="RBID">PMC:4643630</idno><idno type="doi">10.1093/jnci/djv219</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000205</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000205</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization</title><author><name sortKey="Zhang, Ben" sort="Zhang, Ben" uniqKey="Zhang B" first="Ben" last="Zhang">Ben Zhang</name></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name></author><author><name sortKey="Delahanty, Ryan J" sort="Delahanty, Ryan J" uniqKey="Delahanty R" first="Ryan J." last="Delahanty">Ryan J. Delahanty</name></author><author><name sortKey="Zeng, Chenjie" sort="Zeng, Chenjie" uniqKey="Zeng C" first="Chenjie" last="Zeng">Chenjie Zeng</name></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name></author><author><name sortKey="Wen, Wanqing" sort="Wen, Wanqing" uniqKey="Wen W" first="Wanqing" last="Wen">Wanqing Wen</name></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name></author><author><name sortKey="Li, Chun" sort="Li, Chun" uniqKey="Li C" first="Chun" last="Li">Chun Li</name></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name></author><author><name sortKey="Perkins, Barbara J" sort="Perkins, Barbara J" uniqKey="Perkins B" first="Barbara J." last="Perkins">Barbara J. Perkins</name></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A." last="Rookus">Matti A. Rookus</name></author><author><name sortKey="Van Den Hurk, Katja" sort="Van Den Hurk, Katja" uniqKey="Van Den Hurk K" first="Katja" last="Van Den Hurk">Katja Van Den Hurk</name></author><author><name sortKey="De Kort, Wim L A M" sort="De Kort, Wim L A M" uniqKey="De Kort W" first="Wim L. A. M." last="De Kort">Wim L. A. M. De Kort</name></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name></author><author><name sortKey="Hallberg, Emily" sort="Hallberg, Emily" uniqKey="Hallberg E" first="Emily" last="Hallberg">Emily Hallberg</name></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name></author><author><name sortKey="Brand, Judith" sort="Brand, Judith" uniqKey="Brand J" first="Judith" last="Brand">Judith Brand</name></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name></author><author><name sortKey="Cordina Duverger, Emilie" sort="Cordina Duverger, Emilie" uniqKey="Cordina Duverger E" first="Emilie" last="Cordina-Duverger">Emilie Cordina-Duverger</name></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name></author><author><name sortKey="Yang, Rongxi" sort="Yang, Rongxi" uniqKey="Yang R" first="Rongxi" last="Yang">Rongxi Yang</name></author><author><name sortKey="Surowy, Harald" sort="Surowy, Harald" uniqKey="Surowy H" first="Harald" last="Surowy">Harald Surowy</name></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name></author><author><name sortKey="Perez, Jose I A" sort="Perez, Jose I A" uniqKey="Perez J" first="Jose I. A." last="Perez">Jose I. A. Perez</name></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name></author><author><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loic Le" last="Marchand">Loic Le Marchand</name></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name></author><author><name sortKey="Tilanus Linthorst, Madeleine M A" sort="Tilanus Linthorst, Madeleine M A" uniqKey="Tilanus Linthorst M" first="Madeleine M. A." last="Tilanus-Linthorst">Madeleine M. A. Tilanus-Linthorst</name></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collée">J. Margriet Collée</name></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name></author><author><name sortKey="Haeberle, Lothar" sort="Haeberle, Lothar" uniqKey="Haeberle L" first="Lothar" last="Haeberle">Lothar Haeberle</name></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name></author><author><name sortKey="Swerdlow, Anthony J" sort="Swerdlow, Anthony J" uniqKey="Swerdlow A" first="Anthony J." last="Swerdlow">Anthony J. Swerdlow</name></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name></author><author><name sortKey="Antonenkova, Natalia" sort="Antonenkova, Natalia" uniqKey="Antonenkova N" first="Natalia" last="Antonenkova">Natalia Antonenkova</name></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name></author><author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name></author><author><name sortKey="Lubi Ski, Jan" sort="Lubi Ski, Jan" uniqKey="Lubi Ski J" first="Jan" last="Lubi Ski">Jan Lubi Ski</name></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name></author><author><name sortKey="Kristensen, Vessela N" sort="Kristensen, Vessela N" uniqKey="Kristensen V" first="Vessela N." last="Kristensen">Vessela N. Kristensen</name></author><author><name sortKey="Grenaker Aln S, Grethe I" sort="Grenaker Aln S, Grethe I" uniqKey="Grenaker Aln S G" first="Grethe I." last="Grenaker Aln S">Grethe I. Grenaker Aln S</name></author><author><name sortKey="Pierce, Brandon L" sort="Pierce, Brandon L" uniqKey="Pierce B" first="Brandon L." last="Pierce">Brandon L. Pierce</name></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name></author><author><name sortKey="Burgess, Stephen" sort="Burgess, Stephen" uniqKey="Burgess S" first="Stephen" last="Burgess">Stephen Burgess</name></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name></author><author><name sortKey="Gammon, Marilie D" sort="Gammon, Marilie D" uniqKey="Gammon M" first="Marilie D." last="Gammon">Marilie D. Gammon</name></author><author><name sortKey="Malone, Kathleen E" sort="Malone, Kathleen E" uniqKey="Malone K" first="Kathleen E." last="Malone">Kathleen E. Malone</name></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="Francois" last="Bacot">Francois Bacot</name></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name></author><author><name sortKey="Maranian, Mel" sort="Maranian, Mel" uniqKey="Maranian M" first="Mel" last="Maranian">Mel Maranian</name></author><author><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S." last="Healey">Catherine S. Healey</name></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name></author><author><name sortKey="Pita, Guillermo" sort="Pita, Guillermo" uniqKey="Pita G" first="Guillermo" last="Pita">Guillermo Pita</name></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M. Rosario" last="Alonso">M. Rosario Alonso</name></author><author><name sortKey="Alvarez, Nuria" sort="Alvarez, Nuria" uniqKey="Alvarez N" first="Nuria" last="Álvarez">Nuria Álvarez</name></author><author><name sortKey="Herrero, Daniel" sort="Herrero, Daniel" uniqKey="Herrero D" first="Daniel" last="Herrero">Daniel Herrero</name></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name></author></analytic><series><title level="j">JNCI Journal of the National Cancer Institute</title><idno type="ISSN">0027-8874</idno><idno type="eISSN">1460-2105</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Epidemiological studies have linked adult height with breast cancer risk in women. However, the magnitude of the association, particularly by subtypes of breast cancer, has not been established. Furthermore, the mechanisms of the association remain unclear.</p></sec><sec><title>Methods:</title><p>We performed a meta-analysis to investigate associations between height and breast cancer risk using data from 159 prospective cohorts totaling 5216302 women, including 113178 events. In a consortium with individual-level data from 46325 case patients and 42482 control subjects, we conducted a Mendelian randomization analysis using a genetic score that comprised 168 height-associated variants as an instrument. This association was further evaluated in a second consortium using summary statistics data from 16003 case patients and 41335 control subjects.</p></sec><sec><title>Results:</title><p>The pooled relative risk of breast cancer was 1.17 (95% confidence interval [CI] = 1.15 to 1.19) per 10cm increase in height in the meta-analysis of prospective studies. In Mendelian randomization analysis, the odds ratio of breast cancer per 10cm increase in genetically predicted height was 1.22 (95% CI = 1.13 to 1.32) in the first consortium and 1.21 (95% CI = 1.05 to 1.39) in the second consortium. The association was found in both premenopausal and postmenopausal women but restricted to hormone receptor–positive breast cancer. Analyses of height-associated variants identified eight new loci associated with breast cancer risk after adjusting for multiple comparisons, including three loci at 1q21.2, <italic>DNAJC27</italic>, and <italic>CCDC91</italic> at genome-wide significance level <italic>P</italic> < 5×10<sup>–8</sup>.</p></sec><sec><title>Conclusions:</title><p>Our study provides strong evidence that adult height is a risk factor for breast cancer in women and certain genetic factors and biological pathways affecting adult height have an important role in the etiology of breast cancer.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Natl Cancer Inst</journal-id><journal-id journal-id-type="iso-abbrev">J. Natl. Cancer Inst</journal-id><journal-id journal-id-type="hwp">jnci</journal-id><journal-id journal-id-type="publisher-id">jnci</journal-id><journal-title-group><journal-title>JNCI Journal of the National Cancer Institute</journal-title></journal-title-group><issn pub-type="ppub">0027-8874</issn><issn pub-type="epub">1460-2105</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>US</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26296642</article-id><article-id pub-id-type="pmc">4643630</article-id><article-id pub-id-type="doi">10.1093/jnci/djv219</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Ben</given-names></name></contrib><contrib contrib-type="author"><name><surname>Shu</surname><given-names>Xiao-Ou</given-names></name></contrib><contrib contrib-type="author"><name><surname>Delahanty</surname><given-names>Ryan J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zeng</surname><given-names>Chenjie</given-names></name></contrib><contrib contrib-type="author"><name><surname>Michailidou</surname><given-names>Kyriaki</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bolla</surname><given-names>Manjeet K.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Qin</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dennis</surname><given-names>Joe</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wen</surname><given-names>Wanqing</given-names></name></contrib><contrib contrib-type="author"><name><surname>Long</surname><given-names>Jirong</given-names></name></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Chun</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Mitul</given-names></name></contrib><contrib contrib-type="author"><name><surname>Perkins</surname><given-names>Barbara J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Czene</surname><given-names>Kamila</given-names></name></contrib><contrib contrib-type="author"><name><surname>Darabi</surname><given-names>Hatef</given-names></name></contrib><contrib contrib-type="author"><name><surname>Eriksson</surname><given-names>Mikael</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bojesen</surname><given-names>Stig E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nordestgaard</surname><given-names>Børge G.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nielsen</surname><given-names>Sune F.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Flyger</surname><given-names>Henrik</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lambrechts</surname><given-names>Diether</given-names></name></contrib><contrib contrib-type="author"><name><surname>Neven</surname><given-names>Patrick</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wildiers</surname><given-names>Hans</given-names></name></contrib><contrib contrib-type="author"><name><surname>Floris</surname><given-names>Giuseppe</given-names></name></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marjanka K.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rookus</surname><given-names>Matti A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>van den Hurk</surname><given-names>Katja</given-names></name></contrib><contrib contrib-type="author"><name><surname>de Kort</surname><given-names>Wim L. 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Margriet</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa C.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tsimiklis</surname><given-names>Helen</given-names></name></contrib><contrib contrib-type="author"><name><surname>Apicella</surname><given-names>Carmel</given-names></name></contrib><contrib contrib-type="author"><name><surname>Slager</surname><given-names>Susan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Toland</surname><given-names>Amanda E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ambrosone</surname><given-names>Christine B.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Yannoukakos</surname><given-names>Drakoulis</given-names></name></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Milne</surname><given-names>Roger L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>McLean</surname><given-names>Catriona</given-names></name></contrib><contrib contrib-type="author"><name><surname>Fasching</surname><given-names>Peter A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Haeberle</surname><given-names>Lothar</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ekici</surname><given-names>Arif B.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Matthias W.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Hermann</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dieffenbach</surname><given-names>Aida Karina</given-names></name></contrib><contrib contrib-type="author"><name><surname>Arndt</surname><given-names>Volker</given-names></name></contrib><contrib contrib-type="author"><name><surname>Stegmaier</surname><given-names>Christa</given-names></name></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Anthony J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ashworth</surname><given-names>Alan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Orr</surname><given-names>Nick</given-names></name></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>Michael</given-names></name></contrib><contrib contrib-type="author"><name><surname>Figueroa</surname><given-names>Jonine</given-names></name></contrib><contrib contrib-type="author"><name><surname>Garcia-Closas</surname><given-names>Montserrat</given-names></name></contrib><contrib contrib-type="author"><name><surname>Brinton</surname><given-names>Louise</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lissowska</surname><given-names>Jolanta</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dumont</surname><given-names>Martine</given-names></name></contrib><contrib contrib-type="author"><name><surname>Winqvist</surname><given-names>Robert</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pylkäs</surname><given-names>Katri</given-names></name></contrib><contrib contrib-type="author"><name><surname>Jukkola-Vuorinen</surname><given-names>Arja</given-names></name></contrib><contrib contrib-type="author"><name><surname>Grip</surname><given-names>Mervi</given-names></name></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name></contrib><contrib contrib-type="author"><name><surname>Brüning</surname><given-names>Thomas</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ko</surname><given-names>Yon-Dschun</given-names></name></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name></contrib><contrib contrib-type="author"><name><surname>Manoukian</surname><given-names>Siranoush</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bonanni</surname><given-names>Bernardo</given-names></name></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bogdanova</surname><given-names>Natalia</given-names></name></contrib><contrib contrib-type="author"><name><surname>Antonenkova</surname><given-names>Natalia</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dörk</surname><given-names>Thilo</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mannermaa</surname><given-names>Arto</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kataja</surname><given-names>Vesa</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kosma</surname><given-names>Veli-Matti</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hartikainen</surname><given-names>Jaana M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Devilee</surname><given-names>Peter</given-names></name></contrib><contrib contrib-type="author"><name><surname>Seynaeve</surname><given-names>Caroline</given-names></name></contrib><contrib contrib-type="author"><name><surname>Van Asperen</surname><given-names>Christi J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lubiński</surname><given-names>Jan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Jaworska-Bieniek</surname><given-names>Katarzyna</given-names></name></contrib><contrib contrib-type="author"><name><surname>Durda</surname><given-names>Katarzyna</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name></contrib><contrib contrib-type="author"><name><surname>Torres</surname><given-names>Diana</given-names></name></contrib><contrib contrib-type="author"><name><surname>Schmutzler</surname><given-names>Rita K.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Neuhausen</surname><given-names>Susan L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Anton-Culver</surname><given-names>Hoda</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kristensen</surname><given-names>Vessela N.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Grenaker Alnæs</surname><given-names>Grethe I.</given-names></name></contrib><contrib contrib-type="author"><collab>the DRIVE Project</collab></contrib><contrib contrib-type="author"><name><surname>Pierce</surname><given-names>Brandon L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kraft</surname><given-names>Peter</given-names></name></contrib><contrib contrib-type="author"><name><surname>Peters</surname><given-names>Ulrike</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lindstrom</surname><given-names>Sara</given-names></name></contrib><contrib contrib-type="author"><name><surname>Seminara</surname><given-names>Daniela</given-names></name></contrib><contrib contrib-type="author"><name><surname>Burgess</surname><given-names>Stephen</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ahsan</surname><given-names>Habibul</given-names></name></contrib><contrib contrib-type="author"><name><surname>Whittemore</surname><given-names>Alice S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>John</surname><given-names>Esther M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gammon</surname><given-names>Marilie D.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Malone</surname><given-names>Kathleen E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tessier</surname><given-names>Daniel C.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Vincent</surname><given-names>Daniel</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bacot</surname><given-names>Francois</given-names></name></contrib><contrib contrib-type="author"><name><surname>Luccarini</surname><given-names>Craig</given-names></name></contrib><contrib contrib-type="author"><name><surname>Baynes</surname><given-names>Caroline</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ahmed</surname><given-names>Shahana</given-names></name></contrib><contrib contrib-type="author"><name><surname>Maranian</surname><given-names>Mel</given-names></name></contrib><contrib contrib-type="author"><name><surname>Healey</surname><given-names>Catherine S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>González-Neira</surname><given-names>Anna</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pita</surname><given-names>Guillermo</given-names></name></contrib><contrib contrib-type="author"><name><surname>Alonso</surname><given-names>M. Rosario</given-names></name></contrib><contrib contrib-type="author"><name><surname>Álvarez</surname><given-names>Nuria</given-names></name></contrib><contrib contrib-type="author"><name><surname>Herrero</surname><given-names>Daniel</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D. P.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hunter</surname><given-names>David J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Zheng</surname><given-names>Wei</given-names></name></contrib><aff id="AF0001"><bold>Affiliations of authors:</bold><institution>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</institution> (BZ, XOS, RJD, CZ, WW, JL, WZ) and<institution>Department of Biostatistics</institution> (CL),<institution>Vanderbilt University School of Medicine</institution>,<country>Nashville, TN</country>;<institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</institution>(KM, MKB, QW, JD, PDPP, DFE) and<institution>Department of Oncology</institution> (AMD, MS, BJP, CL, CB, SA, MM, CSH, PDPP, DFE),<institution>University of Cambridge</institution>,<country>Cambridge, UK</country>;<institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country> (KC, HD, ME);<institution>Copenhagen General Population Study</institution> (SEB, BGN, SFN),<institution>Department of Clinical Biochemistry</institution> (SEB, BGN, SFN), and<institution>Department of Breast Surgery</institution> (HF),<institution>Herlev Hospital</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>;<institution>Faculty of Health and Medical Sciences, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country> (SEB, BGN);<institution>Vesalius Research Center</institution> (VRC),<addr-line>VIB, Leuven</addr-line>,<country>Belgium</country> (DL);<institution>Laboratory for Translational Genetics, Department of Oncology, University of Leuven</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country> (DL);<institution>University Hospitals Leuven and Department of Oncology</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country> (PN, HW, GF);<institution>Netherlands Cancer Institute</institution>,<addr-line>Amsterdam</addr-line>,<country>the Netherlands</country> (MKS, MAR);<institution>Division Research, Department of Donor Studies, Sanquin Blood Supply</institution>,<addr-line>Amsterdam</addr-line>,<country>the Netherlands</country> (KVDH, WLAMDK);<institution>Department of Laboratory Medicine and Pathology</institution> (FJC) and<institution>Department of Health Sciences Research</institution> (JEO, EH, CV, SS),<institution>Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<country>MN</country>;<institution>Division of Cancer Epidemiology, German Cancer Research Center</institution> (DKFZ),<addr-line>Heidelberg</addr-line>,<country>Germany</country> (JCC, AR, PS);<institution>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country> (DFJ);<institution>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine</institution>,<country>London, UK</country> (JP, IDSS);<institution>Breakthrough Breast Cancer Research Centre, the Institute of Cancer Research</institution>,<country>London, UK</country> (OF, NJ);<institution>Department of Obstetrics and Gynecology</institution> (HN, TAM),<institution>Department of Clinical Genetics</institution> (KA), and<institution>Department of Oncology</institution> (CB),<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>;<institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country> (PH, KH, JB);<institution>Human Genetics Division, Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country> (JL);<institution>Inserm</institution> (National Institute of Health and Medical Research),<institution>CESP (Center for Research in Epidemiology and Population Health), Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country> (PG, TT, ECD, FM);<institution>University Paris-Sud</institution>,<addr-line>Villejuif</addr-line>,<country>France</country> (PG, TT, ECD, FM);<institution>Department of Obstetrics and Gynecology</institution> (BB, FM, RY, HS) and<institution>National Center for Tumor Diseases</institution> (FM),<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>;<institution>Molecular Epidemiology Group, German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country> (BB, RY, HS);<institution>Human Genetics Group, Spanish National Research Center</institution> (CNIO),<institution>Human Genotyping Center</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country> (JB);<institution>Oncology Service, Hospital La Paz</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country> (MPZ);<institution>Surgery Service, Hospital Monte Naranco</institution>,<addr-line>Oviedo</addr-line>,<country>Spain</country> (JIAP);<institution>Department of Oncology</institution> (AC, MWRR) and<institution>Department of Neuroscience</institution> (SSC),<institution>University of Sheffield</institution>,<country>Sheffield, UK</country>;<institution>Department of Molecular Genetics</institution> (ILA),<institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution> (GG, ST),<institution>University of Toronto</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country>;<institution>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Ontario, Canada</country> (JAK);<institution>Research Oncology, Division of Cancer Studies, Guy’s Hospital, King’s College London</institution>,<country>London, UK</country> (EJS);<institution>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford</institution>,<country>UK</country> (IT);<institution>Clinical Science Institute, University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country> (MJK, NM);<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country> (GCT, Australian Ovarian Cancer Study Group);<institution>Peter MacCallum Cancer Center</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country> (kConFab Investigators, Australian Ovarian Cancer Study Group);<institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>,<country>Los Angeles, CA</country> (CAH, BEH, FS);<institution>Epidemiology Program, Cancer Research Center, University of Hawaii</institution>,<country>Honolulu, HI</country> (LLM);<institution>Department of Molecular Medicine and Surgery</institution> (AL) and<institution>Department of Oncology-Pathology</institution> (SM),<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>;<institution>Family Cancer Clinic, Department of Medical Oncology</institution> (MJH, JWMM),<institution>Department of Surgical Oncology</institution> (MMATL), and<institution>Department of Clinical Genetics</institution> (JMC),<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>the Netherlands</country>;<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, the University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country> (JLH, CA, GGG, RLM);<institution>Department of Pathology, the University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country> (MCS, HT);<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country> (GGG, RLM);<institution>Anatomical Pathology, the Alfred Hospital</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country> (CM);<institution>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, the Ohio State University</institution>,<country>Columbus, OH</country> (AET);<institution>Roswell Park Cancer Institute</institution>,<country>Buffalo, NY</country> (CBA);<institution>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research “Demokritos,”</institution><addr-line>Athens</addr-line>,<country>Greece</country> (DY);<institution>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country> (PAF, LH, MWB);<institution>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles</institution>,<country>CA</country> (PAF);<institution>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country> (ABE);<institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center</institution> (DKFZ),<addr-line>Heidelberg</addr-line>,<country>Germany</country> (HB, AKD, VA);<institution>Saarland Cancer Registry</institution>,<addr-line>Saarbrücken</addr-line>,<country>Germany</country> (CS);<institution>Division of Breast Cancer Research</institution> (AA, NO, AJS) and<institution>Division of Genetics and Epidemiology</institution> (MJ, AJS),<institution>Institute of Cancer Research</institution>,<country>London, UK</country>;<institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>,<country>Gaithersburg, MD</country>, (JF, LB);<institution>Division of Genetics and Epidemiology and Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research</institution>,<country>London, UK</country> (MGC);<institution>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country> (JL);<institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City</institution>,<addr-line>Quebec</addr-line>,<country>Canada</country> (JS, MD);<institution>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, NordLab Oulu/Oulu University Hospital</institution> (RW, KP),<institution>Department of Oncology</institution> (AJV), and<institution>Department of Surgery</institution> (MG),<institution>University of Oulu, Oulu, Finland; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, University Tübingen, German Cancer Consortium</institution> (DKTK) and<institution>German Cancer Research Center</institution> (DKFZ),<addr-line>Heidelberg</addr-line>,<country>Germany</country> (HB, The GENICA Network);<institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum</institution> (IPA),<addr-line>Bochum</addr-line>,<country>Germany</country> (TB, The GENICA Network);<institution>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country> (YDK, The GENICA Network);<institution>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum</institution> (DKFZ),<addr-line>Heidelberg</addr-line>,<country>Germany</country> (The GENICA Network);<institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country> (PP);<institution>Unit of Medical Genetics</institution> (SM) and<institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing</institution> (PR),<institution>Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori</institution> (INT),<addr-line>Milan</addr-line>,<country>Italy</country> (SM);<institution>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia</institution> (IEO),<addr-line>Milan</addr-line>,<country>Italy</country> (BB);<institution>Department of Radiation Oncology</institution> and<institution>Department of Obstetrics and Gynaecology</institution> (TD),<institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>;<institution>N. N. Alexandrov Research Institute of Oncology and Medical Radiology</institution>,<addr-line>Minsk</addr-line>,<country>Belarus</country> (NA); Imaging Center, Department of Clinical Pathology (AM, VMK, JMH) and Cancer Center (AM,VK, VMK, JMH), Kuopio University Hospital, Kuopio, Finland; Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland (AM, VMK, JMH); Central Finland Hospital District, Jyväskylä Central Hospital, Jyväskylä, Finland (VK);<institution>Department of Human Genetics and Department of Pathology</institution> (PD) and<institution>Department of Clinical Genetics</institution> (CJVA),<institution>Leiden University Medical Center</institution>,<addr-line>Leiden</addr-line>,<country>the Netherlands</country> (PD);<institution>Family Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Centre</institution>,<addr-line>Rotterdam</addr-line>,<country>the Netherlands</country> (CS);<institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country> (AJ, JL, KJB, KD);<institution>Molecular Genetics of Breast Cancer, German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country> (UH, DT);<institution>Institute of Human Genetics, Pontificia University Javeriana</institution>,<addr-line>Bogota</addr-line>,<country>Colombia</country> (DT);<institution>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics and Center of Familial Breast and Ovarian Cancer and Center for Integrated Oncology</institution>,<institution>University Hospital of Cologne</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country> (RKS);<institution>Center for Molecular Medicine Cologne</institution>,<institution>University of Cologne</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country> (RKS);<institution>Department of Population Sciences, Beckman Research Institute of City of Hope</institution>,<country>Duarte, CA</country> (SLN);<institution>Department of Epidemiology, University of California Irvine</institution>,<country>Irvine, CA</country> (HAC);<institution>Department of Genetics, Institute for Cancer Research, Oslo University Hospital</institution>,<addr-line>Radiumhospitalet, Oslo</addr-line>,<country>Norway</country> (VNK, GIGA);<institution>Institute of Clinical Medicine and Department of Clinical Molecular Biology, University of Oslo</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country> (VNK);<institution>Department of Health Studies, the University of Chicago</institution>,<country>Chicago, IL</country> (BLP, HA);<institution>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health</institution>,<country>Boston, MA</country> (PK, SL, DJH);<institution>Public Health Sciences Division, Fred Hutchinson Cancer Research Center</institution>,<country>Seattle, WA</country> (UP);<institution>Division of Cancer Control and Population Sciences, National Cancer Institute</institution>,<country>Bethesda, MD</country> (DS);<institution>Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory</institution>,<addr-line>2 Worts Causeway</addr-line>,<country>Cambridge, UK</country> (SB);<institution>Department of Medicine and Department of Human Genetics and the University of Chicago Comprehensive Cancer Center, the University of Chicago</institution>,<country>Chicago, IL</country> (HA);<institution>Department of Health Research and Policy and Stanford Cancer Institute, Stanford University School of Medicine</institution>,<country>Stanford, CA</country> (ASW, EMJ);<institution>Cancer Prevention Institute of California</institution>,<country>Fremont, CA</country> (EMJ);<institution>Department of Epidemiology, University of North Carolina</institution>,<country>Chapel Hill, NC</country> (MDG);<institution>Division of Public Health Sciences, Program in Epidemiology, Fred Hutchinson Cancer Research Center</institution>,<country>Seattle, WA</country> (KEM);<institution>McGill University and Génome Québec Innovation Centre</institution>,<addr-line>Montréal, QC</addr-line>,<country>Canada</country> (DCT, DV, FB);<institution>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country> (AGN, GP, MRA, NA, DH).</aff></contrib-group><author-notes><corresp id="c1"><bold>Correspondence to:</bold> Wei Zheng, MD, PhD, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Eighth Floor, Nashville, TN 37203-1738 (e-mail: <email>wei.zheng@vanderbilt.edu</email>).</corresp></author-notes><pub-date pub-type="collection"><month>11</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>20</day><month>8</month><year>2015</year></pub-date><volume>107</volume><issue>11</issue><elocation-id>djv219</elocation-id><history><date date-type="received"><day>4</day><month>8</month><year>2014</year></date><date date-type="rev-recd"><day>3</day><month>2</month><year>2015</year></date><date date-type="accepted"><day>15</day><month>7</month><year>2015</year></date></history><permissions><copyright-statement>© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><sec><title>Background:</title><p>Epidemiological studies have linked adult height with breast cancer risk in women. However, the magnitude of the association, particularly by subtypes of breast cancer, has not been established. Furthermore, the mechanisms of the association remain unclear.</p></sec><sec><title>Methods:</title><p>We performed a meta-analysis to investigate associations between height and breast cancer risk using data from 159 prospective cohorts totaling 5216302 women, including 113178 events. In a consortium with individual-level data from 46325 case patients and 42482 control subjects, we conducted a Mendelian randomization analysis using a genetic score that comprised 168 height-associated variants as an instrument. This association was further evaluated in a second consortium using summary statistics data from 16003 case patients and 41335 control subjects.</p></sec><sec><title>Results:</title><p>The pooled relative risk of breast cancer was 1.17 (95% confidence interval [CI] = 1.15 to 1.19) per 10cm increase in height in the meta-analysis of prospective studies. In Mendelian randomization analysis, the odds ratio of breast cancer per 10cm increase in genetically predicted height was 1.22 (95% CI = 1.13 to 1.32) in the first consortium and 1.21 (95% CI = 1.05 to 1.39) in the second consortium. The association was found in both premenopausal and postmenopausal women but restricted to hormone receptor–positive breast cancer. Analyses of height-associated variants identified eight new loci associated with breast cancer risk after adjusting for multiple comparisons, including three loci at 1q21.2, <italic>DNAJC27</italic>, and <italic>CCDC91</italic> at genome-wide significance level <italic>P</italic> < 5×10<sup>–8</sup>.</p></sec><sec><title>Conclusions:</title><p>Our study provides strong evidence that adult height is a risk factor for breast cancer in women and certain genetic factors and biological pathways affecting adult height have an important role in the etiology of breast cancer.</p></sec></abstract><counts><page-count count="17"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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