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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells</title><author><name sortKey="Ju, Young Seok" sort="Ju, Young Seok" uniqKey="Ju Y" first="Young Seok" last="Ju">Young Seok Ju</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Tubio, Jose M C" sort="Tubio, Jose M C" uniqKey="Tubio J" first="Jose M. C." last="Tubio">Jose M. C. Tubio</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Mifsud, William" sort="Mifsud, William" uniqKey="Mifsud W" first="William" last="Mifsud">William Mifsud</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Fu, Beiyuan" sort="Fu, Beiyuan" uniqKey="Fu B" first="Beiyuan" last="Fu">Beiyuan Fu</name><affiliation><nlm:aff id="af2">Cytogenetics Facility, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Davies, Helen R" sort="Davies, Helen R" uniqKey="Davies H" first="Helen R." last="Davies">Helen R. Davies</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Ramakrishna, Manasa" sort="Ramakrishna, Manasa" uniqKey="Ramakrishna M" first="Manasa" last="Ramakrishna">Manasa Ramakrishna</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Li, Yilong" sort="Li, Yilong" uniqKey="Li Y" first="Yilong" last="Li">Yilong Li</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Yates, Lucy" sort="Yates, Lucy" uniqKey="Yates L" first="Lucy" last="Yates">Lucy Yates</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Gundem, Gunes" sort="Gundem, Gunes" uniqKey="Gundem G" first="Gunes" last="Gundem">Gunes Gundem</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Tarpey, Patrick S" sort="Tarpey, Patrick S" uniqKey="Tarpey P" first="Patrick S." last="Tarpey">Patrick S. Tarpey</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Behjati, Sam" sort="Behjati, Sam" uniqKey="Behjati S" first="Sam" last="Behjati">Sam Behjati</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Papaemmanuil, Elli" sort="Papaemmanuil, Elli" uniqKey="Papaemmanuil E" first="Elli" last="Papaemmanuil">Elli Papaemmanuil</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Martin, Sancha" sort="Martin, Sancha" uniqKey="Martin S" first="Sancha" last="Martin">Sancha Martin</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Fullam, Anthony" sort="Fullam, Anthony" uniqKey="Fullam A" first="Anthony" last="Fullam">Anthony Fullam</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Gerstung, Moritz" sort="Gerstung, Moritz" uniqKey="Gerstung M" first="Moritz" last="Gerstung">Moritz Gerstung</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Nangalia, Jyoti" sort="Nangalia, Jyoti" uniqKey="Nangalia J" first="Jyoti" last="Nangalia">Jyoti Nangalia</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af3">Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af4">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Green, Anthony R" sort="Green, Anthony R" uniqKey="Green A" first="Anthony R." last="Green">Anthony R. Green</name><affiliation><nlm:aff id="af3">Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af4">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Caldas, Carlos" sort="Caldas, Carlos" uniqKey="Caldas C" first="Carlos" last="Caldas">Carlos Caldas</name><affiliation><nlm:aff id="af3">Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af5">Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Borg, Ke" sort="Borg, Ke" uniqKey="Borg " first=" Ke" last="Borg"> Ke Borg</name><affiliation><nlm:aff id="af6">BioCare, Strategic Cancer Research Program, SE-223 81 Lund, Sweden;</nlm:aff></affiliation><affiliation><nlm:aff id="af7">CREATE Health, Strategic Centre for Translational Cancer Research, SE-221 00 Lund, Sweden;</nlm:aff></affiliation><affiliation><nlm:aff id="af8">Department of Oncology and Pathology, Lund University Cancer Center, SE-221 85 Lund, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Tutt, Andrew" sort="Tutt, Andrew" uniqKey="Tutt A" first="Andrew" last="Tutt">Andrew Tutt</name><affiliation><nlm:aff id="af9">Breakthrough Breast Cancer Research Unit, Research Oncology, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Lee, Ming Ta Michael" sort="Lee, Ming Ta Michael" uniqKey="Lee M" first="Ming Ta Michael" last="Lee">Ming Ta Michael Lee</name><affiliation><nlm:aff id="af10">Laboratory for International Alliance on Genomic Research, RIKEN Center for Integrative Medical Sciences, 230-0045 Yokohama, Japan;</nlm:aff></affiliation><affiliation><nlm:aff id="af11">National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan;</nlm:aff></affiliation></author><author><name sortKey="Van T Veer, Laura J" sort="Van T Veer, Laura J" uniqKey="Van T Veer L" first="Laura J." last="Van'T Veer">Laura J. Van'T Veer</name><affiliation><nlm:aff id="af12">Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, USA;</nlm:aff></affiliation><affiliation><nlm:aff id="af13">Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Tan, Benita K T" sort="Tan, Benita K T" uniqKey="Tan B" first="Benita K. T." last="Tan">Benita K. T. Tan</name><affiliation><nlm:aff id="af14">Department of General Surgery, Singapore General Hospital, Singapore 169608;</nlm:aff></affiliation></author><author><name sortKey="Aparicio, Samuel" sort="Aparicio, Samuel" uniqKey="Aparicio S" first="Samuel" last="Aparicio">Samuel Aparicio</name><affiliation><nlm:aff id="af15">Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada;</nlm:aff></affiliation></author><author><name sortKey="Span, Paul N" sort="Span, Paul N" uniqKey="Span P" first="Paul N." last="Span">Paul N. Span</name><affiliation><nlm:aff id="af16">Department of Radiation Oncology and Department of Laboratory Medicine, Radboud University Medical Center, 6525 HP Nijmegen, Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="af17">Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CE Rotterdam, Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Knappskog, Stian" sort="Knappskog, Stian" uniqKey="Knappskog S" first="Stian" last="Knappskog">Stian Knappskog</name><affiliation><nlm:aff id="af18">Section of Oncology, Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway;</nlm:aff></affiliation><affiliation><nlm:aff id="af19">Department of Oncology, Haukeland University Hospital, 5021 Bergen, Norway;</nlm:aff></affiliation></author><author><name sortKey="Vincent Salomon, Anne" sort="Vincent Salomon, Anne" uniqKey="Vincent Salomon A" first="Anne" last="Vincent-Salomon">Anne Vincent-Salomon</name><affiliation><nlm:aff id="af20">Institut Curie, INSERM U934 and Department of Tumor Biology, 75248 Paris cédex 05, France;</nlm:aff></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation><nlm:aff id="af21">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway;</nlm:aff></affiliation><affiliation><nlm:aff id="af22">The K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0450 Oslo, Norway;</nlm:aff></affiliation></author><author><name sortKey="Eyfjord, J Runn Erla" sort="Eyfjord, J Runn Erla" uniqKey="Eyfjord J" first="J Runn Erla" last="Eyfjörd">J Runn Erla Eyfjörd</name><affiliation><nlm:aff id="af23">Cancer Research Laboratory, University of Iceland, 101 Reykjavik, Iceland;</nlm:aff></affiliation></author><author><name sortKey="Flanagan, Adrienne M" sort="Flanagan, Adrienne M" uniqKey="Flanagan A" first="Adrienne M." last="Flanagan">Adrienne M. Flanagan</name><affiliation><nlm:aff id="af24">Royal National Orthopaedic Hospital, Middlesex HA7 4LP, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af25">UCL Cancer Institute, University College London, London WC1E 6DD, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Foster, Christopher" sort="Foster, Christopher" uniqKey="Foster C" first="Christopher" last="Foster">Christopher Foster</name><affiliation><nlm:aff id="af26">University of Liverpool and HCA Pathology Laboratories, London WC1E 6JA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><affiliation><nlm:aff id="af27">Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge CB2 0RE, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af28">Department of Surgical Oncology, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Cooper, Colin" sort="Cooper, Colin" uniqKey="Cooper C" first="Colin" last="Cooper">Colin Cooper</name><affiliation><nlm:aff id="af29">Institute of Cancer Research, Sutton, London SM2 5NG, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af30">Department of Biological Sciences and School of Medicine, University of East Anglia, Norwich NR4 7TJ, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name><affiliation><nlm:aff id="af31">Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton SM2 5NG, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af32">Royal Marsden NHS Foundation Trust, London SW3 6JJ and Sutton SM2 5PT, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R." last="Lakhani">Sunil R. Lakhani</name><affiliation><nlm:aff id="af33">University of Queensland, School of Medicine, Brisbane, QLD 4006, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="af34">Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="af35">University of Queensland, UQ Centre for Clinical Research, Brisbane, QLD 4029, Australia;</nlm:aff></affiliation></author><author><name sortKey="Desmedt, Christine" sort="Desmedt, Christine" uniqKey="Desmedt C" first="Christine" last="Desmedt">Christine Desmedt</name><affiliation><nlm:aff id="af36">Breast Cancer Translational Research Laboratory, Université Libre de Bruxelles, Institut Jules Bordet, 1000 Brussels, Belgium;</nlm:aff></affiliation></author><author><name sortKey="Thomas, Gilles" sort="Thomas, Gilles" uniqKey="Thomas G" first="Gilles" last="Thomas">Gilles Thomas</name><affiliation><nlm:aff id="af37">Université Lyon 1, Institut National du Cancer (INCa)–Synergie, 69008 Lyon, France;</nlm:aff></affiliation></author><author><name sortKey="Richardson, Andrea L" sort="Richardson, Andrea L" uniqKey="Richardson A" first="Andrea L." last="Richardson">Andrea L. Richardson</name><affiliation><nlm:aff id="af38">Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA;</nlm:aff></affiliation><affiliation><nlm:aff id="af39">Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA;</nlm:aff></affiliation></author><author><name sortKey="Purdie, Colin A" sort="Purdie, Colin A" uniqKey="Purdie C" first="Colin A." last="Purdie">Colin A. Purdie</name><affiliation><nlm:aff id="af40">Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Thompson, Alastair M" sort="Thompson, Alastair M" uniqKey="Thompson A" first="Alastair M." last="Thompson">Alastair M. Thompson</name><affiliation><nlm:aff id="af41">Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Mcdermott, Ultan" sort="Mcdermott, Ultan" uniqKey="Mcdermott U" first="Ultan" last="Mcdermott">Ultan Mcdermott</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Yang, Fengtang" sort="Yang, Fengtang" uniqKey="Yang F" first="Fengtang" last="Yang">Fengtang Yang</name><affiliation><nlm:aff id="af2">Cytogenetics Facility, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Nik Zainal, Serena" sort="Nik Zainal, Serena" uniqKey="Nik Zainal S" first="Serena" last="Nik-Zainal">Serena Nik-Zainal</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J." last="Campbell">Peter J. Campbell</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25963125</idno><idno type="pmc">4448678</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448678</idno><idno type="RBID">PMC:4448678</idno><idno type="doi">10.1101/gr.190470.115</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000186</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000186</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells</title><author><name sortKey="Ju, Young Seok" sort="Ju, Young Seok" uniqKey="Ju Y" first="Young Seok" last="Ju">Young Seok Ju</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Tubio, Jose M C" sort="Tubio, Jose M C" uniqKey="Tubio J" first="Jose M. C." last="Tubio">Jose M. C. Tubio</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Mifsud, William" sort="Mifsud, William" uniqKey="Mifsud W" first="William" last="Mifsud">William Mifsud</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Fu, Beiyuan" sort="Fu, Beiyuan" uniqKey="Fu B" first="Beiyuan" last="Fu">Beiyuan Fu</name><affiliation><nlm:aff id="af2">Cytogenetics Facility, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Davies, Helen R" sort="Davies, Helen R" uniqKey="Davies H" first="Helen R." last="Davies">Helen R. Davies</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Ramakrishna, Manasa" sort="Ramakrishna, Manasa" uniqKey="Ramakrishna M" first="Manasa" last="Ramakrishna">Manasa Ramakrishna</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Li, Yilong" sort="Li, Yilong" uniqKey="Li Y" first="Yilong" last="Li">Yilong Li</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Yates, Lucy" sort="Yates, Lucy" uniqKey="Yates L" first="Lucy" last="Yates">Lucy Yates</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Gundem, Gunes" sort="Gundem, Gunes" uniqKey="Gundem G" first="Gunes" last="Gundem">Gunes Gundem</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Tarpey, Patrick S" sort="Tarpey, Patrick S" uniqKey="Tarpey P" first="Patrick S." last="Tarpey">Patrick S. Tarpey</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Behjati, Sam" sort="Behjati, Sam" uniqKey="Behjati S" first="Sam" last="Behjati">Sam Behjati</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Papaemmanuil, Elli" sort="Papaemmanuil, Elli" uniqKey="Papaemmanuil E" first="Elli" last="Papaemmanuil">Elli Papaemmanuil</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Martin, Sancha" sort="Martin, Sancha" uniqKey="Martin S" first="Sancha" last="Martin">Sancha Martin</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Fullam, Anthony" sort="Fullam, Anthony" uniqKey="Fullam A" first="Anthony" last="Fullam">Anthony Fullam</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Gerstung, Moritz" sort="Gerstung, Moritz" uniqKey="Gerstung M" first="Moritz" last="Gerstung">Moritz Gerstung</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Nangalia, Jyoti" sort="Nangalia, Jyoti" uniqKey="Nangalia J" first="Jyoti" last="Nangalia">Jyoti Nangalia</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af3">Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af4">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Green, Anthony R" sort="Green, Anthony R" uniqKey="Green A" first="Anthony R." last="Green">Anthony R. Green</name><affiliation><nlm:aff id="af3">Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af4">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Caldas, Carlos" sort="Caldas, Carlos" uniqKey="Caldas C" first="Carlos" last="Caldas">Carlos Caldas</name><affiliation><nlm:aff id="af3">Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af5">Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Borg, Ke" sort="Borg, Ke" uniqKey="Borg " first=" Ke" last="Borg"> Ke Borg</name><affiliation><nlm:aff id="af6">BioCare, Strategic Cancer Research Program, SE-223 81 Lund, Sweden;</nlm:aff></affiliation><affiliation><nlm:aff id="af7">CREATE Health, Strategic Centre for Translational Cancer Research, SE-221 00 Lund, Sweden;</nlm:aff></affiliation><affiliation><nlm:aff id="af8">Department of Oncology and Pathology, Lund University Cancer Center, SE-221 85 Lund, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Tutt, Andrew" sort="Tutt, Andrew" uniqKey="Tutt A" first="Andrew" last="Tutt">Andrew Tutt</name><affiliation><nlm:aff id="af9">Breakthrough Breast Cancer Research Unit, Research Oncology, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Lee, Ming Ta Michael" sort="Lee, Ming Ta Michael" uniqKey="Lee M" first="Ming Ta Michael" last="Lee">Ming Ta Michael Lee</name><affiliation><nlm:aff id="af10">Laboratory for International Alliance on Genomic Research, RIKEN Center for Integrative Medical Sciences, 230-0045 Yokohama, Japan;</nlm:aff></affiliation><affiliation><nlm:aff id="af11">National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan;</nlm:aff></affiliation></author><author><name sortKey="Van T Veer, Laura J" sort="Van T Veer, Laura J" uniqKey="Van T Veer L" first="Laura J." last="Van'T Veer">Laura J. Van'T Veer</name><affiliation><nlm:aff id="af12">Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, USA;</nlm:aff></affiliation><affiliation><nlm:aff id="af13">Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Tan, Benita K T" sort="Tan, Benita K T" uniqKey="Tan B" first="Benita K. T." last="Tan">Benita K. T. Tan</name><affiliation><nlm:aff id="af14">Department of General Surgery, Singapore General Hospital, Singapore 169608;</nlm:aff></affiliation></author><author><name sortKey="Aparicio, Samuel" sort="Aparicio, Samuel" uniqKey="Aparicio S" first="Samuel" last="Aparicio">Samuel Aparicio</name><affiliation><nlm:aff id="af15">Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada;</nlm:aff></affiliation></author><author><name sortKey="Span, Paul N" sort="Span, Paul N" uniqKey="Span P" first="Paul N." last="Span">Paul N. Span</name><affiliation><nlm:aff id="af16">Department of Radiation Oncology and Department of Laboratory Medicine, Radboud University Medical Center, 6525 HP Nijmegen, Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="af17">Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CE Rotterdam, Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Knappskog, Stian" sort="Knappskog, Stian" uniqKey="Knappskog S" first="Stian" last="Knappskog">Stian Knappskog</name><affiliation><nlm:aff id="af18">Section of Oncology, Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway;</nlm:aff></affiliation><affiliation><nlm:aff id="af19">Department of Oncology, Haukeland University Hospital, 5021 Bergen, Norway;</nlm:aff></affiliation></author><author><name sortKey="Vincent Salomon, Anne" sort="Vincent Salomon, Anne" uniqKey="Vincent Salomon A" first="Anne" last="Vincent-Salomon">Anne Vincent-Salomon</name><affiliation><nlm:aff id="af20">Institut Curie, INSERM U934 and Department of Tumor Biology, 75248 Paris cédex 05, France;</nlm:aff></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation><nlm:aff id="af21">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway;</nlm:aff></affiliation><affiliation><nlm:aff id="af22">The K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0450 Oslo, Norway;</nlm:aff></affiliation></author><author><name sortKey="Eyfjord, J Runn Erla" sort="Eyfjord, J Runn Erla" uniqKey="Eyfjord J" first="J Runn Erla" last="Eyfjörd">J Runn Erla Eyfjörd</name><affiliation><nlm:aff id="af23">Cancer Research Laboratory, University of Iceland, 101 Reykjavik, Iceland;</nlm:aff></affiliation></author><author><name sortKey="Flanagan, Adrienne M" sort="Flanagan, Adrienne M" uniqKey="Flanagan A" first="Adrienne M." last="Flanagan">Adrienne M. Flanagan</name><affiliation><nlm:aff id="af24">Royal National Orthopaedic Hospital, Middlesex HA7 4LP, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af25">UCL Cancer Institute, University College London, London WC1E 6DD, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Foster, Christopher" sort="Foster, Christopher" uniqKey="Foster C" first="Christopher" last="Foster">Christopher Foster</name><affiliation><nlm:aff id="af26">University of Liverpool and HCA Pathology Laboratories, London WC1E 6JA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><affiliation><nlm:aff id="af27">Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge CB2 0RE, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af28">Department of Surgical Oncology, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Cooper, Colin" sort="Cooper, Colin" uniqKey="Cooper C" first="Colin" last="Cooper">Colin Cooper</name><affiliation><nlm:aff id="af29">Institute of Cancer Research, Sutton, London SM2 5NG, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af30">Department of Biological Sciences and School of Medicine, University of East Anglia, Norwich NR4 7TJ, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name><affiliation><nlm:aff id="af31">Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton SM2 5NG, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="af32">Royal Marsden NHS Foundation Trust, London SW3 6JJ and Sutton SM2 5PT, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R." last="Lakhani">Sunil R. Lakhani</name><affiliation><nlm:aff id="af33">University of Queensland, School of Medicine, Brisbane, QLD 4006, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="af34">Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="af35">University of Queensland, UQ Centre for Clinical Research, Brisbane, QLD 4029, Australia;</nlm:aff></affiliation></author><author><name sortKey="Desmedt, Christine" sort="Desmedt, Christine" uniqKey="Desmedt C" first="Christine" last="Desmedt">Christine Desmedt</name><affiliation><nlm:aff id="af36">Breast Cancer Translational Research Laboratory, Université Libre de Bruxelles, Institut Jules Bordet, 1000 Brussels, Belgium;</nlm:aff></affiliation></author><author><name sortKey="Thomas, Gilles" sort="Thomas, Gilles" uniqKey="Thomas G" first="Gilles" last="Thomas">Gilles Thomas</name><affiliation><nlm:aff id="af37">Université Lyon 1, Institut National du Cancer (INCa)–Synergie, 69008 Lyon, France;</nlm:aff></affiliation></author><author><name sortKey="Richardson, Andrea L" sort="Richardson, Andrea L" uniqKey="Richardson A" first="Andrea L." last="Richardson">Andrea L. Richardson</name><affiliation><nlm:aff id="af38">Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA;</nlm:aff></affiliation><affiliation><nlm:aff id="af39">Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA;</nlm:aff></affiliation></author><author><name sortKey="Purdie, Colin A" sort="Purdie, Colin A" uniqKey="Purdie C" first="Colin A." last="Purdie">Colin A. Purdie</name><affiliation><nlm:aff id="af40">Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Thompson, Alastair M" sort="Thompson, Alastair M" uniqKey="Thompson A" first="Alastair M." last="Thompson">Alastair M. Thompson</name><affiliation><nlm:aff id="af41">Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Mcdermott, Ultan" sort="Mcdermott, Ultan" uniqKey="Mcdermott U" first="Ultan" last="Mcdermott">Ultan Mcdermott</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Yang, Fengtang" sort="Yang, Fengtang" uniqKey="Yang F" first="Fengtang" last="Yang">Fengtang Yang</name><affiliation><nlm:aff id="af2">Cytogenetics Facility, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Nik Zainal, Serena" sort="Nik Zainal, Serena" uniqKey="Nik Zainal S" first="Serena" last="Nik-Zainal">Serena Nik-Zainal</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J." last="Campbell">Peter J. Campbell</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><affiliation><nlm:aff id="af1">Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</nlm:aff></affiliation></author></analytic><series><title level="j">Genome Research</title><idno type="ISSN">1088-9051</idno><idno type="eISSN">1549-5469</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm, and the mitochondrial double membrane. Despite these physical barriers, we show that somatically acquired mitochondrial-nuclear genome fusion sequences are present in cancer cells. Most occur in conjunction with intranuclear genomic rearrangements, and the features of the fusion fragments indicate that nonhomologous end joining and/or replication-dependent DNA double-strand break repair are the dominant mechanisms involved. Remarkably, mitochondrial-nuclear genome fusions occur at a similar rate per base pair of DNA as interchromosomal nuclear rearrangements, indicating the presence of a high frequency of contact between mitochondrial and nuclear DNA in some somatic cells. Transmission of mitochondrial DNA to the nuclear genome occurs in neoplastically transformed cells, but we do not exclude the possibility that some mitochondrial-nuclear DNA fusions observed in cancer occurred years earlier in normal somatic cells.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Genome Res</journal-id><journal-id journal-id-type="iso-abbrev">Genome Res</journal-id><journal-id journal-id-type="hwp">genome</journal-id><journal-id journal-id-type="pmc">genome</journal-id><journal-id journal-id-type="publisher-id">GENOME</journal-id><journal-title-group><journal-title>Genome Research</journal-title></journal-title-group><issn pub-type="ppub">1088-9051</issn><issn pub-type="epub">1549-5469</issn><publisher><publisher-name>Cold Spring Harbor Laboratory Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25963125</article-id><article-id pub-id-type="pmc">4448678</article-id><article-id pub-id-type="medline">9509184</article-id><article-id pub-id-type="doi">10.1101/gr.190470.115</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells</article-title><alt-title alt-title-type="left-running">Ju et al.</alt-title><alt-title alt-title-type="right-running">Nuclear integration of mitochondrial DNA in cancer</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ju</surname><given-names>Young Seok</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tubio</surname><given-names>Jose M.C.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="author-notes" rid="FN2">43</xref></contrib><contrib contrib-type="author"><name><surname>Mifsud</surname><given-names>William</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="author-notes" rid="FN2">43</xref></contrib><contrib contrib-type="author"><name><surname>Fu</surname><given-names>Beiyuan</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Davies</surname><given-names>Helen R.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ramakrishna</surname><given-names>Manasa</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Yilong</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yates</surname><given-names>Lucy</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gundem</surname><given-names>Gunes</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tarpey</surname><given-names>Patrick S.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Behjati</surname><given-names>Sam</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Papaemmanuil</surname><given-names>Elli</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Sancha</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Fullam</surname><given-names>Anthony</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gerstung</surname><given-names>Moritz</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><collab>ICGC Prostate Cancer Working Group</collab><xref ref-type="author-notes" rid="FN3">44</xref></contrib><contrib contrib-type="author"><collab>ICGC Bone Cancer Working Group</collab><xref ref-type="author-notes" rid="FN3">44</xref></contrib><contrib contrib-type="author"><collab>ICGC Breast Cancer Working Group</collab><xref ref-type="author-notes" rid="FN3">44</xref></contrib><contrib contrib-type="author"><name><surname>Nangalia</surname><given-names>Jyoti</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Green</surname><given-names>Anthony R.</given-names></name><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Caldas</surname><given-names>Carlos</given-names></name><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Borg</surname><given-names>Åke</given-names></name><xref ref-type="aff" rid="af6">6</xref><xref ref-type="aff" rid="af7">7</xref><xref ref-type="aff" rid="af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Tutt</surname><given-names>Andrew</given-names></name><xref ref-type="aff" rid="af9">9</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Ming Ta Michael</given-names></name><xref ref-type="aff" rid="af10">10</xref><xref ref-type="aff" rid="af11">11</xref></contrib><contrib contrib-type="author"><name><surname>van't Veer</surname><given-names>Laura J.</given-names></name><xref ref-type="aff" rid="af12">12</xref><xref ref-type="aff" rid="af13">13</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Benita K.T.</given-names></name><xref ref-type="aff" rid="af14">14</xref></contrib><contrib contrib-type="author"><name><surname>Aparicio</surname><given-names>Samuel</given-names></name><xref ref-type="aff" rid="af15">15</xref></contrib><contrib contrib-type="author"><name><surname>Span</surname><given-names>Paul N.</given-names></name><xref ref-type="aff" rid="af16">16</xref></contrib><contrib contrib-type="author"><name><surname>Martens</surname><given-names>John W.M.</given-names></name><xref ref-type="aff" rid="af17">17</xref></contrib><contrib contrib-type="author"><name><surname>Knappskog</surname><given-names>Stian</given-names></name><xref ref-type="aff" rid="af18">18</xref><xref ref-type="aff" rid="af19">19</xref></contrib><contrib contrib-type="author"><name><surname>Vincent-Salomon</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="af20">20</xref></contrib><contrib contrib-type="author"><name><surname>Børresen-Dale</surname><given-names>Anne-Lise</given-names></name><xref ref-type="aff" rid="af21">21</xref><xref ref-type="aff" rid="af22">22</xref></contrib><contrib contrib-type="author"><name><surname>Eyfjörd</surname><given-names>Jórunn Erla</given-names></name><xref ref-type="aff" rid="af23">23</xref></contrib><contrib contrib-type="author"><name><surname>Flanagan</surname><given-names>Adrienne M.</given-names></name><xref ref-type="aff" rid="af24">24</xref><xref ref-type="aff" rid="af25">25</xref></contrib><contrib contrib-type="author"><name><surname>Foster</surname><given-names>Christopher</given-names></name><xref ref-type="aff" rid="af26">26</xref></contrib><contrib contrib-type="author"><name><surname>Neal</surname><given-names>David E.</given-names></name><xref ref-type="aff" rid="af27">27</xref><xref ref-type="aff" rid="af28">28</xref></contrib><contrib contrib-type="author"><name><surname>Cooper</surname><given-names>Colin</given-names></name><xref ref-type="aff" rid="af29">29</xref><xref ref-type="aff" rid="af30">30</xref></contrib><contrib contrib-type="author"><name><surname>Eeles</surname><given-names>Rosalind</given-names></name><xref ref-type="aff" rid="af31">31</xref><xref ref-type="aff" rid="af32">32</xref></contrib><contrib contrib-type="author"><name><surname>Lakhani</surname><given-names>Sunil R.</given-names></name><xref ref-type="aff" rid="af33">33</xref><xref ref-type="aff" rid="af34">34</xref><xref ref-type="aff" rid="af35">35</xref></contrib><contrib contrib-type="author"><name><surname>Desmedt</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="af36">36</xref></contrib><contrib contrib-type="author"><name><surname>Thomas</surname><given-names>Gilles</given-names></name><xref ref-type="aff" rid="af37">37</xref><xref ref-type="author-notes" rid="FN1">42</xref></contrib><contrib contrib-type="author"><name><surname>Richardson</surname><given-names>Andrea L.</given-names></name><xref ref-type="aff" rid="af38">38</xref><xref ref-type="aff" rid="af39">39</xref></contrib><contrib contrib-type="author"><name><surname>Purdie</surname><given-names>Colin A.</given-names></name><xref ref-type="aff" rid="af40">40</xref></contrib><contrib contrib-type="author"><name><surname>Thompson</surname><given-names>Alastair M.</given-names></name><xref ref-type="aff" rid="af41">41</xref></contrib><contrib contrib-type="author"><name><surname>McDermott</surname><given-names>Ultan</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Fengtang</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Nik-Zainal</surname><given-names>Serena</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Campbell</surname><given-names>Peter J.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Stratton</surname><given-names>Michael R.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib></contrib-group><aff id="af1"><label>1</label>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</aff><aff id="af2"><label>2</label>Cytogenetics Facility, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;</aff><aff id="af3"><label>3</label>Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom;</aff><aff id="af4"><label>4</label>Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom;</aff><aff id="af5"><label>5</label>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom;</aff><aff id="af6"><label>6</label>BioCare, Strategic Cancer Research Program, SE-223 81 Lund, Sweden;</aff><aff id="af7"><label>7</label>CREATE Health, Strategic Centre for Translational Cancer Research, SE-221 00 Lund, Sweden;</aff><aff id="af8"><label>8</label>Department of Oncology and Pathology, Lund University Cancer Center, SE-221 85 Lund, Sweden;</aff><aff id="af9"><label>9</label>Breakthrough Breast Cancer Research Unit, Research Oncology, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom;</aff><aff id="af10"><label>10</label>Laboratory for International Alliance on Genomic Research, RIKEN Center for Integrative Medical Sciences, 230-0045 Yokohama, Japan;</aff><aff id="af11"><label>11</label>National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan;</aff><aff id="af12"><label>12</label>Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, USA;</aff><aff id="af13"><label>13</label>Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands;</aff><aff id="af14"><label>14</label>Department of General Surgery, Singapore General Hospital, Singapore 169608;</aff><aff id="af15"><label>15</label>Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada;</aff><aff id="af16"><label>16</label>Department of Radiation Oncology and Department of Laboratory Medicine, Radboud University Medical Center, 6525 HP Nijmegen, Netherlands;</aff><aff id="af17"><label>17</label>Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CE Rotterdam, Netherlands;</aff><aff id="af18"><label>18</label>Section of Oncology, Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway;</aff><aff id="af19"><label>19</label>Department of Oncology, Haukeland University Hospital, 5021 Bergen, Norway;</aff><aff id="af20"><label>20</label>Institut Curie, INSERM U934 and Department of Tumor Biology, 75248 Paris cédex 05, France;</aff><aff id="af21"><label>21</label>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway;</aff><aff id="af22"><label>22</label>The K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0450 Oslo, Norway;</aff><aff id="af23"><label>23</label>Cancer Research Laboratory, University of Iceland, 101 Reykjavik, Iceland;</aff><aff id="af24"><label>24</label>Royal National Orthopaedic Hospital, Middlesex HA7 4LP, United Kingdom;</aff><aff id="af25"><label>25</label>UCL Cancer Institute, University College London, London WC1E 6DD, United Kingdom;</aff><aff id="af26"><label>26</label>University of Liverpool and HCA Pathology Laboratories, London WC1E 6JA, United Kingdom;</aff><aff id="af27"><label>27</label>Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge CB2 0RE, United Kingdom;</aff><aff id="af28"><label>28</label>Department of Surgical Oncology, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom;</aff><aff id="af29"><label>29</label>Institute of Cancer Research, Sutton, London SM2 5NG, United Kingdom;</aff><aff id="af30"><label>30</label>Department of Biological Sciences and School of Medicine, University of East Anglia, Norwich NR4 7TJ, United Kingdom;</aff><aff id="af31"><label>31</label>Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton SM2 5NG, United Kingdom;</aff><aff id="af32"><label>32</label>Royal Marsden NHS Foundation Trust, London SW3 6JJ and Sutton SM2 5PT, United Kingdom;</aff><aff id="af33"><label>33</label>University of Queensland, School of Medicine, Brisbane, QLD 4006, Australia;</aff><aff id="af34"><label>34</label>Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia;</aff><aff id="af35"><label>35</label>University of Queensland, UQ Centre for Clinical Research, Brisbane, QLD 4029, Australia;</aff><aff id="af36"><label>36</label>Breast Cancer Translational Research Laboratory, Université Libre de Bruxelles, Institut Jules Bordet, 1000 Brussels, Belgium;</aff><aff id="af37"><label>37</label>Université Lyon 1, Institut National du Cancer (INCa)–Synergie, 69008 Lyon, France;</aff><aff id="af38"><label>38</label>Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA;</aff><aff id="af39"><label>39</label>Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA;</aff><aff id="af40"><label>40</label>Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom;</aff><aff id="af41"><label>41</label>Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA</aff><author-notes><fn fn-type="deceased" id="FN1"><label>42</label><p>Deceased.</p></fn><fn fn-type="equal" id="FN2"><label>43</label><p>These authors contributed equally to this work.</p></fn><fn id="FN3"><label>44</label><p>A full list of members is provided in the Supplemental Material.</p></fn><corresp>Corresponding author: <email>mrs@sanger.ac.uk</email></corresp></author-notes><pub-date pub-type="ppub"><month>6</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><month>6</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>25</volume><issue>6</issue><fpage>814</fpage><lpage>824</lpage><history><date date-type="received"><day>3</day><month>2</month><year>2015</year></date><date date-type="accepted"><day>14</day><month>4</month><year>2015</year></date></history><permissions><copyright-statement><ext-link ext-link-type="uri" xlink:href="http://genome.cshlp.org/site/misc/terms.xhtml">© 2015 Ju et al.; Published by Cold Spring Harbor Laboratory Press</ext-link></copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This article, published in <italic>Genome Research</italic>, is available under a Creative Commons License (Attribution 4.0 International), as described at <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="814.pdf"></self-uri><abstract><p>Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm, and the mitochondrial double membrane. Despite these physical barriers, we show that somatically acquired mitochondrial-nuclear genome fusion sequences are present in cancer cells. Most occur in conjunction with intranuclear genomic rearrangements, and the features of the fusion fragments indicate that nonhomologous end joining and/or replication-dependent DNA double-strand break repair are the dominant mechanisms involved. Remarkably, mitochondrial-nuclear genome fusions occur at a similar rate per base pair of DNA as interchromosomal nuclear rearrangements, indicating the presence of a high frequency of contact between mitochondrial and nuclear DNA in some somatic cells. Transmission of mitochondrial DNA to the nuclear genome occurs in neoplastically transformed cells, but we do not exclude the possibility that some mitochondrial-nuclear DNA fusions observed in cancer occurred years earlier in normal somatic cells.</p></abstract><funding-group><award-group id="funding-1"><funding-source>European Molecular Biology Organization long-term fellowship (LTF) <named-content content-type="funder-id">http://dx.doi.org/10.13039/100004410</named-content></funding-source><award-id>1203_2012</award-id></award-group><award-group id="funding-2"><funding-source>Marie Curie Fellowship</funding-source><award-id>FP7-PEOPLE-2012-IEF</award-id><award-id>328264</award-id></award-group><award-group id="funding-3"><funding-source>Wellcome Trust Senior Clinical Fellow <named-content content-type="funder-id">http://dx.doi.org/10.13039/100004440</named-content></funding-source></award-group><award-group id="funding-4"><funding-source>National Institute for Health Research (NIHR) UCLH Biomedical Research Centre <named-content content-type="funder-id">http://dx.doi.org/10.13039/501100000272</named-content></funding-source></award-group><award-group id="funding-5"><funding-source>Wellcome Trust <named-content content-type="funder-id">http://dx.doi.org/10.13039/100004440</named-content></funding-source></award-group><award-group id="funding-6"><funding-source>Dallaglio Foundation</funding-source><award-id>C5047/A14835</award-id></award-group><award-group id="funding-7"><funding-source>National Institute for Health Research <named-content content-type="funder-id">http://dx.doi.org/10.13039/501100000272</named-content></funding-source></award-group><award-group id="funding-8"><funding-source>Biomedical Research Centre</funding-source></award-group><award-group id="funding-9"><funding-source>The Institute of Cancer Research and Royal Marsden NHS Foundation Trust</funding-source></award-group><award-group id="funding-10"><funding-source>National Cancer Research Prostate Cancer Mechanisms of Progression and Treatment (PROMPT)</funding-source><award-id>G0500966/75466</award-id></award-group><award-group id="funding-11"><funding-source>National Institute for Health Research <named-content content-type="funder-id">http://dx.doi.org/10.13039/501100000272</named-content></funding-source><award-id>ICGC 08/09</award-id><award-id>KCL</award-id></award-group></funding-group><counts><page-count count="11"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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