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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The NB-LRR proteins RGA4 and RGA5 interact functionally and physically to confer disease resistance</title><author><name sortKey="Cesari, Stella" sort="Cesari, Stella" uniqKey="Cesari S" first="Stella" last="Césari">Stella Césari</name><affiliation><nlm:aff id="au1"><institution>INRA, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>CIRAD, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>CSIRO Plant Industry</institution><addr-line>Canberra, ACT, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kanzaki, Hiroyuki" sort="Kanzaki, Hiroyuki" uniqKey="Kanzaki H" first="Hiroyuki" last="Kanzaki">Hiroyuki Kanzaki</name><affiliation><nlm:aff id="au4"><institution>Iwate Biotechnology Research Center</institution><addr-line>Kitakami, Iwate, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fujiwara, Tadashi" sort="Fujiwara, Tadashi" uniqKey="Fujiwara T" first="Tadashi" last="Fujiwara">Tadashi Fujiwara</name><affiliation><nlm:aff id="au5"><institution>Laboratory of Plant Molecular Genetics, Nara Institute of Science and Technology</institution><addr-line>Takayama, Ikoma, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bernoux, Maud" sort="Bernoux, Maud" uniqKey="Bernoux M" first="Maud" last="Bernoux">Maud Bernoux</name><affiliation><nlm:aff id="au3"><institution>CSIRO Plant Industry</institution><addr-line>Canberra, ACT, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chalvon, Veronique" sort="Chalvon, Veronique" uniqKey="Chalvon V" first="Véronique" last="Chalvon">Véronique Chalvon</name><affiliation><nlm:aff id="au1"><institution>INRA, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>CIRAD, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kawano, Yoji" sort="Kawano, Yoji" uniqKey="Kawano Y" first="Yoji" last="Kawano">Yoji Kawano</name><affiliation><nlm:aff id="au5"><institution>Laboratory of Plant Molecular Genetics, Nara Institute of Science and Technology</institution><addr-line>Takayama, Ikoma, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shimamoto, Ko" sort="Shimamoto, Ko" uniqKey="Shimamoto K" first="Ko" last="Shimamoto">Ko Shimamoto</name><affiliation><nlm:aff id="au5"><institution>Laboratory of Plant Molecular Genetics, Nara Institute of Science and Technology</institution><addr-line>Takayama, Ikoma, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dodds, Peter" sort="Dodds, Peter" uniqKey="Dodds P" first="Peter" last="Dodds">Peter Dodds</name><affiliation><nlm:aff id="au3"><institution>CSIRO Plant Industry</institution><addr-line>Canberra, ACT, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Terauchi, Ryohei" sort="Terauchi, Ryohei" uniqKey="Terauchi R" first="Ryohei" last="Terauchi">Ryohei Terauchi</name><affiliation><nlm:aff id="au4"><institution>Iwate Biotechnology Research Center</institution><addr-line>Kitakami, Iwate, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kroj, Thomas" sort="Kroj, Thomas" uniqKey="Kroj T" first="Thomas" last="Kroj">Thomas Kroj</name><affiliation><nlm:aff id="au1"><institution>INRA, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>CIRAD, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25024433</idno><idno type="pmc">4195788</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195788</idno><idno type="RBID">PMC:4195788</idno><idno type="doi">10.15252/embj.201487923</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000183</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000183</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The NB-LRR proteins RGA4 and RGA5 interact functionally and physically to confer disease resistance</title><author><name sortKey="Cesari, Stella" sort="Cesari, Stella" uniqKey="Cesari S" first="Stella" last="Césari">Stella Césari</name><affiliation><nlm:aff id="au1"><institution>INRA, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>CIRAD, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>CSIRO Plant Industry</institution><addr-line>Canberra, ACT, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kanzaki, Hiroyuki" sort="Kanzaki, Hiroyuki" uniqKey="Kanzaki H" first="Hiroyuki" last="Kanzaki">Hiroyuki Kanzaki</name><affiliation><nlm:aff id="au4"><institution>Iwate Biotechnology Research Center</institution><addr-line>Kitakami, Iwate, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fujiwara, Tadashi" sort="Fujiwara, Tadashi" uniqKey="Fujiwara T" first="Tadashi" last="Fujiwara">Tadashi Fujiwara</name><affiliation><nlm:aff id="au5"><institution>Laboratory of Plant Molecular Genetics, Nara Institute of Science and Technology</institution><addr-line>Takayama, Ikoma, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bernoux, Maud" sort="Bernoux, Maud" uniqKey="Bernoux M" first="Maud" last="Bernoux">Maud Bernoux</name><affiliation><nlm:aff id="au3"><institution>CSIRO Plant Industry</institution><addr-line>Canberra, ACT, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chalvon, Veronique" sort="Chalvon, Veronique" uniqKey="Chalvon V" first="Véronique" last="Chalvon">Véronique Chalvon</name><affiliation><nlm:aff id="au1"><institution>INRA, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>CIRAD, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kawano, Yoji" sort="Kawano, Yoji" uniqKey="Kawano Y" first="Yoji" last="Kawano">Yoji Kawano</name><affiliation><nlm:aff id="au5"><institution>Laboratory of Plant Molecular Genetics, Nara Institute of Science and Technology</institution><addr-line>Takayama, Ikoma, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shimamoto, Ko" sort="Shimamoto, Ko" uniqKey="Shimamoto K" first="Ko" last="Shimamoto">Ko Shimamoto</name><affiliation><nlm:aff id="au5"><institution>Laboratory of Plant Molecular Genetics, Nara Institute of Science and Technology</institution><addr-line>Takayama, Ikoma, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dodds, Peter" sort="Dodds, Peter" uniqKey="Dodds P" first="Peter" last="Dodds">Peter Dodds</name><affiliation><nlm:aff id="au3"><institution>CSIRO Plant Industry</institution><addr-line>Canberra, ACT, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Terauchi, Ryohei" sort="Terauchi, Ryohei" uniqKey="Terauchi R" first="Ryohei" last="Terauchi">Ryohei Terauchi</name><affiliation><nlm:aff id="au4"><institution>Iwate Biotechnology Research Center</institution><addr-line>Kitakami, Iwate, Japan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kroj, Thomas" sort="Kroj, Thomas" uniqKey="Kroj T" first="Thomas" last="Kroj">Thomas Kroj</name><affiliation><nlm:aff id="au1"><institution>INRA, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>CIRAD, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">The EMBO Journal</title><idno type="ISSN">0261-4189</idno><idno type="eISSN">1460-2075</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Plant resistance proteins of the class of nucleotide-binding and leucine-rich repeat domain proteins (NB-LRRs) are immune sensors which recognize pathogen-derived molecules termed avirulence (AVR) proteins. We show that RGA4 and RGA5, two NB-LRRs from rice, interact functionally and physically to mediate resistance to the fungal pathogen <italic>Magnaporthe oryzae</italic> and accomplish different functions in AVR recognition. RGA4 triggers an AVR-independent cell death that is repressed in the presence of RGA5 in both rice protoplasts and <italic>Nicotiana benthamiana</italic>. Upon recognition of the pathogen effector AVR-Pia by direct binding to RGA5, repression is relieved and cell death occurs. RGA4 and RGA5 form homo- and hetero-complexes and interact through their coiled-coil domains. Localization studies in rice protoplast suggest that RGA4 and RGA5 localize to the cytosol. Upon recognition of AVR-Pia, neither RGA4 nor RGA5 is re-localized to the nucleus. These results establish a model for the interaction of hetero-pairs of NB-LRRs in plants: RGA4 mediates cell death activation, while RGA5 acts as a repressor of RGA4 and as an AVR receptor.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">EMBO J</journal-id><journal-id journal-id-type="iso-abbrev">EMBO J</journal-id><journal-id journal-id-type="publisher-id">embj</journal-id><journal-title-group><journal-title>The EMBO Journal</journal-title></journal-title-group><issn pub-type="ppub">0261-4189</issn><issn pub-type="epub">1460-2075</issn><publisher><publisher-name>BlackWell Publishing Ltd</publisher-name><publisher-loc>Oxford, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25024433</article-id><article-id pub-id-type="pmc">4195788</article-id><article-id pub-id-type="doi">10.15252/embj.201487923</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>The NB-LRR proteins RGA4 and RGA5 interact functionally and physically to confer disease resistance</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Césari</surname><given-names>Stella</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref><xref ref-type="aff" rid="au3">3</xref><xref ref-type="author-notes" rid="fn1">†</xref></contrib><contrib contrib-type="author"><name><surname>Kanzaki</surname><given-names>Hiroyuki</given-names></name><xref ref-type="aff" rid="au4">4</xref><xref ref-type="author-notes" rid="fn1">†</xref></contrib><contrib contrib-type="author"><name><surname>Fujiwara</surname><given-names>Tadashi</given-names></name><xref ref-type="aff" rid="au5">5</xref><xref ref-type="author-notes" rid="fn1">†</xref></contrib><contrib contrib-type="author"><name><surname>Bernoux</surname><given-names>Maud</given-names></name><xref ref-type="aff" rid="au3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chalvon</surname><given-names>Véronique</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Kawano</surname><given-names>Yoji</given-names></name><xref ref-type="aff" rid="au5">5</xref></contrib><contrib contrib-type="author"><name><surname>Shimamoto</surname><given-names>Ko</given-names></name><xref ref-type="aff" rid="au5">5</xref><xref ref-type="author-notes" rid="fn2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Dodds</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="au3">3</xref></contrib><contrib contrib-type="author"><name><surname>Terauchi</surname><given-names>Ryohei</given-names></name><xref ref-type="aff" rid="au4">4</xref></contrib><contrib contrib-type="author"><name><surname>Kroj</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><aff id="au1"><label>1</label><institution>INRA, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></aff><aff id="au2"><label>2</label><institution>CIRAD, UMR BGPI</institution><addr-line>Montpellier, France</addr-line></aff><aff id="au3"><label>3</label><institution>CSIRO Plant Industry</institution><addr-line>Canberra, ACT, Australia</addr-line></aff><aff id="au4"><label>4</label><institution>Iwate Biotechnology Research Center</institution><addr-line>Kitakami, Iwate, Japan</addr-line></aff><aff id="au5"><label>5</label><institution>Laboratory of Plant Molecular Genetics, Nara Institute of Science and Technology</institution><addr-line>Takayama, Ikoma, Japan</addr-line></aff></contrib-group><author-notes><corresp id="cor1">*Corresponding author. Tel: +33 4 99 62 48 62; E-mail: <email>thomas.kroj@supagro.inra.fr</email></corresp><fn id="fn1"><label>†</label><p>These authors contributed equally to this work</p></fn><fn id="fn2"><label>‡</label><p>Dedicated to Ko Shimamoto, who passed away on September 28, 2013</p></fn><fn><p>The author responsible for distribution of materials integral to the findings presented in this article is: Thomas Kroj (<email>thomas.kroj@supagro.inra.fr</email>)</p></fn><fn><p><bold>Subject Categories</bold> Immunology; Plant Biology</p></fn></author-notes><pub-date pub-type="ppub"><day>01</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>14</day><month>7</month><year>2014</year></pub-date><volume>33</volume><issue>17</issue><fpage>1941</fpage><lpage>1959</lpage><history><date date-type="received"><day>26</day><month>1</month><year>2014</year></date><date date-type="rev-recd"><day>20</day><month>5</month><year>2014</year></date><date date-type="accepted"><day>05</day><month>6</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 The Authors</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p>Plant resistance proteins of the class of nucleotide-binding and leucine-rich repeat domain proteins (NB-LRRs) are immune sensors which recognize pathogen-derived molecules termed avirulence (AVR) proteins. We show that RGA4 and RGA5, two NB-LRRs from rice, interact functionally and physically to mediate resistance to the fungal pathogen <italic>Magnaporthe oryzae</italic> and accomplish different functions in AVR recognition. RGA4 triggers an AVR-independent cell death that is repressed in the presence of RGA5 in both rice protoplasts and <italic>Nicotiana benthamiana</italic>. Upon recognition of the pathogen effector AVR-Pia by direct binding to RGA5, repression is relieved and cell death occurs. RGA4 and RGA5 form homo- and hetero-complexes and interact through their coiled-coil domains. Localization studies in rice protoplast suggest that RGA4 and RGA5 localize to the cytosol. Upon recognition of AVR-Pia, neither RGA4 nor RGA5 is re-localized to the nucleus. These results establish a model for the interaction of hetero-pairs of NB-LRRs in plants: RGA4 mediates cell death activation, while RGA5 acts as a repressor of RGA4 and as an AVR receptor.</p></abstract><kwd-group><kwd><italic>Magnaporthe oryzae</italic></kwd><kwd>pathogen recognition</kwd><kwd>plant immunity</kwd><kwd>resistance protein</kwd><kwd>rice</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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