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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer</title><author><name sortKey="Khalili, Hamed" sort="Khalili, Hamed" uniqKey="Khalili H" first="Hamed" last="Khalili">Hamed Khalili</name><affiliation><nlm:aff id="AF0001"><institution>Gastrointestinal Unit</institution>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="AF0003"><institution>Division of Clinical Epidemiology and Aging Research</institution>,<institution>German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0004"><institution>German Cancer Cosortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Austin, Thomas R" sort="Austin, Thomas R" uniqKey="Austin T" first="Thomas R." last="Austin">Thomas R. Austin</name><affiliation><nlm:aff id="AF0005"><institution>Whitman College</institution>,<addr-line>Walla Walla, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M." last="Hutter">Carolyn M. Hutter</name><affiliation><nlm:aff id="AF0006"><institution>Division of Cancer Control and Population Sciences, National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Baba, Yoshifumi" sort="Baba, Yoshifumi" uniqKey="Baba Y" first="Yoshifumi" last="Baba">Yoshifumi Baba</name><affiliation><nlm:aff id="AF0007"><institution>Department of Gastroenterological Surgery</institution>,<institution>Kumamoto University</institution>,<addr-line>Kumamoto</addr-line>,<country>Japan</country>,</nlm:aff></affiliation></author><author><name sortKey="Baron, John A" sort="Baron, John A" uniqKey="Baron J" first="John A." last="Baron">John A. Baron</name><affiliation><nlm:aff id="AF0008"><institution>Department of Medicine, School of Medicine</institution>,<institution>University of North Carolina</institution>,<addr-line>Chapel Hill</addr-line>,<addr-line>NC</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="AF0009"><institution>Division of Cancer Epidemiology and Genetics</institution>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name><affiliation><nlm:aff id="AF0010"><institution>CHU Nantes, Service de Génétique Médicale</institution>,<addr-line>Nantes</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Caan, Bette" sort="Caan, Bette" uniqKey="Caan B" first="Bette" last="Caan">Bette Caan</name><affiliation><nlm:aff id="AF0011"><institution>Division of Hematology</institution>,<institution>Faculty of Medicine</institution>,<institution>The University of Ottawa</institution>,<addr-line>Ottawa</addr-line>,<addr-line>ON</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Campbell, Peter T" sort="Campbell, Peter T" uniqKey="Campbell P" first="Peter T." last="Campbell">Peter T. Campbell</name><affiliation><nlm:aff id="AF0012"><institution>Epidemiology Research Program, American Cancer Society</institution>,<addr-line>Atlanta</addr-line>,<addr-line>GA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="AF0013"><institution>Division of Cancer Epidemiology</institution>,<institution>German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="AF0009"><institution>Division of Cancer Epidemiology and Genetics</institution>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name><affiliation><nlm:aff id="AF0014"><institution>Program in Molecular and Genetic Epidemiology</institution>,<institution>Harvard T.H. Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Jiao, Shuo" sort="Jiao, Shuo" uniqKey="Jiao S" first="Shuo" last="Jiao">Shuo Jiao</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name><affiliation><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name><affiliation><nlm:aff id="AF0016"><institution>Systems Imagination, Computational Biology</institution>,<addr-line>Pheonix</addr-line>,<addr-line>AZ</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S." last="Fuchs">Charles S. Fuchs</name><affiliation><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gala, Manish" sort="Gala, Manish" uniqKey="Gala M" first="Manish" last="Gala">Manish Gala</name><affiliation><nlm:aff id="AF0001"><institution>Gastrointestinal Unit</institution>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation><nlm:aff id="AF0019"><institution>Department of Surgery, University Health Network Toronto General Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>ON</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W." last="Haile">Robert W. Haile</name><affiliation><nlm:aff id="AF0020"><institution>Stanford Cancer Institute</institution>,<addr-line>Palo Alto, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A." last="Harrison">Tabitha A. Harrison</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hayes, Richard" sort="Hayes, Richard" uniqKey="Hayes R" first="Richard" last="Hayes">Richard Hayes</name><affiliation><nlm:aff id="AF0021"><institution>Division of Epidemiology</institution>,<institution>New York University School of Medicine</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><affiliation><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Haiman, Chris" sort="Haiman, Chris" uniqKey="Haiman C" first="Chris" last="Haiman">Chris Haiman</name><affiliation><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation><nlm:aff id="AF0003"><institution>Division of Clinical Epidemiology and Aging Research</institution>,<institution>German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="AF0022"><institution>Melbourne School of Population Health</institution>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name><affiliation><nlm:aff id="AF0021"><institution>Division of Epidemiology</institution>,<institution>New York University School of Medicine</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation><nlm:aff id="AF0023"><institution>Epidemiology Program</institution>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><affiliation><nlm:aff id="AF0010"><institution>CHU Nantes, Service de Génétique Médicale</institution>,<addr-line>Nantes</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loic Le" last="Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="AF0023"><institution>Epidemiology Program</institution>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation><nlm:aff id="AF0024"><institution>Ontario Institute for Cancer Research</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation><nlm:aff id="AF0025"><institution>Department of Health Science Services, Mayo Clinic</institution>,<addr-line>Scottsdale</addr-line>,<addr-line>AZ</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E." last="Manson">Joann E. Manson</name><affiliation><nlm:aff id="AF0026"><institution>Department of Medicine</institution>,<institution>Brigham and Women’s Hospital</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Morikawa, Teppei" sort="Morikawa, Teppei" uniqKey="Morikawa T" first="Teppei" last="Morikawa">Teppei Morikawa</name><affiliation><nlm:aff id="AF0027"><institution>Department of Pathology</institution>,<institution>The University of Tokyo Hospital</institution>,<addr-line>Tokyo</addr-line>,<country>Japan</country>,</nlm:aff></affiliation></author><author><name sortKey="Nan, Hongmei" sort="Nan, Hongmei" uniqKey="Nan H" first="Hongmei" last="Nan">Hongmei Nan</name><affiliation><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ng, Kimmie" sort="Ng, Kimmie" uniqKey="Ng K" first="Kimmie" last="Ng">Kimmie Ng</name><affiliation><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Nishihara, Reiko" sort="Nishihara, Reiko" uniqKey="Nishihara R" first="Reiko" last="Nishihara">Reiko Nishihara</name><affiliation><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0028"><institution>Department of Nutrition, Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0029"><institution>Department of Epidemiology</institution>,<institution>University of Washington</institution>,<addr-line>Seattle</addr-line>,<addr-line>WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0030"><institution>Center for Public Health Research, Massey University</institution>,<addr-line>Wellington</addr-line>,<country>New Zealand</country>,</nlm:aff></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation><nlm:aff id="AF0031"><institution>Department of Medicine and Epidemiology</institution>,<institution>University of Pittsburgh Medical Center</institution>,<addr-line>Pittsburgh</addr-line>,<addr-line>PA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:aff id="AF0006"><institution>Division of Cancer Control and Population Sciences, National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Taverna, Darin" sort="Taverna, Darin" uniqKey="Taverna D" first="Darin" last="Taverna">Darin Taverna</name><affiliation><nlm:aff id="AF0016"><institution>Systems Imagination, Computational Biology</institution>,<addr-line>Pheonix</addr-line>,<addr-line>AZ</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Thibodeau, Stephen" sort="Thibodeau, Stephen" uniqKey="Thibodeau S" first="Stephen" last="Thibodeau">Stephen Thibodeau</name><affiliation><nlm:aff id="AF0032"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<addr-line>MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><affiliation><nlm:aff id="AF0033"><institution>Department of Social and Preventive Medicine</institution>,<institution>University of Buffalo</institution>,<addr-line>Buffalo</addr-line>,<addr-line>NY</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><affiliation><nlm:aff id="AF0028"><institution>Department of Nutrition, Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W." last="Zanke">Brent W. Zanke</name><affiliation><nlm:aff id="AF0034"><institution>Clinical Epidemiology Program, Ottawa Hospital Research Institute</institution>,<addr-line>Ottawa</addr-line>,<addr-line>ON</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation><nlm:aff id="AF0024"><institution>Ontario Institute for Cancer Research</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0035"><institution>Department of Medical Biophysics</institution>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<addr-line>ON</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="AF0014"><institution>Program in Molecular and Genetic Epidemiology</institution>,<institution>Harvard T.H. Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation><nlm:aff id="AF0036"><institution>Department of Internal Medicine</institution>,<institution>University of Utah Health Sciences Center</institution>,<addr-line>Salt Lake City</addr-line>,<addr-line>UT</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><affiliation><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0037"><institution>Department of Pathology</institution>,<institution>Brigham and Women’s Hospital</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0038"><institution>Department of Epidemiology</institution>,<institution>Harvard T.H. Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation><nlm:aff id="AF0001"><institution>Gastrointestinal Unit</institution>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26071399</idno><idno type="pmc">4573660</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573660</idno><idno type="RBID">PMC:4573660</idno><idno type="doi">10.1093/carcin/bgv086</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000178</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000178</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer</title><author><name sortKey="Khalili, Hamed" sort="Khalili, Hamed" uniqKey="Khalili H" first="Hamed" last="Khalili">Hamed Khalili</name><affiliation><nlm:aff id="AF0001"><institution>Gastrointestinal Unit</institution>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="AF0003"><institution>Division of Clinical Epidemiology and Aging Research</institution>,<institution>German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0004"><institution>German Cancer Cosortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Austin, Thomas R" sort="Austin, Thomas R" uniqKey="Austin T" first="Thomas R." last="Austin">Thomas R. Austin</name><affiliation><nlm:aff id="AF0005"><institution>Whitman College</institution>,<addr-line>Walla Walla, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M." last="Hutter">Carolyn M. Hutter</name><affiliation><nlm:aff id="AF0006"><institution>Division of Cancer Control and Population Sciences, National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Baba, Yoshifumi" sort="Baba, Yoshifumi" uniqKey="Baba Y" first="Yoshifumi" last="Baba">Yoshifumi Baba</name><affiliation><nlm:aff id="AF0007"><institution>Department of Gastroenterological Surgery</institution>,<institution>Kumamoto University</institution>,<addr-line>Kumamoto</addr-line>,<country>Japan</country>,</nlm:aff></affiliation></author><author><name sortKey="Baron, John A" sort="Baron, John A" uniqKey="Baron J" first="John A." last="Baron">John A. Baron</name><affiliation><nlm:aff id="AF0008"><institution>Department of Medicine, School of Medicine</institution>,<institution>University of North Carolina</institution>,<addr-line>Chapel Hill</addr-line>,<addr-line>NC</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="AF0009"><institution>Division of Cancer Epidemiology and Genetics</institution>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name><affiliation><nlm:aff id="AF0010"><institution>CHU Nantes, Service de Génétique Médicale</institution>,<addr-line>Nantes</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Caan, Bette" sort="Caan, Bette" uniqKey="Caan B" first="Bette" last="Caan">Bette Caan</name><affiliation><nlm:aff id="AF0011"><institution>Division of Hematology</institution>,<institution>Faculty of Medicine</institution>,<institution>The University of Ottawa</institution>,<addr-line>Ottawa</addr-line>,<addr-line>ON</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Campbell, Peter T" sort="Campbell, Peter T" uniqKey="Campbell P" first="Peter T." last="Campbell">Peter T. Campbell</name><affiliation><nlm:aff id="AF0012"><institution>Epidemiology Research Program, American Cancer Society</institution>,<addr-line>Atlanta</addr-line>,<addr-line>GA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="AF0013"><institution>Division of Cancer Epidemiology</institution>,<institution>German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="AF0009"><institution>Division of Cancer Epidemiology and Genetics</institution>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name><affiliation><nlm:aff id="AF0014"><institution>Program in Molecular and Genetic Epidemiology</institution>,<institution>Harvard T.H. Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Jiao, Shuo" sort="Jiao, Shuo" uniqKey="Jiao S" first="Shuo" last="Jiao">Shuo Jiao</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name><affiliation><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name><affiliation><nlm:aff id="AF0016"><institution>Systems Imagination, Computational Biology</institution>,<addr-line>Pheonix</addr-line>,<addr-line>AZ</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S." last="Fuchs">Charles S. Fuchs</name><affiliation><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gala, Manish" sort="Gala, Manish" uniqKey="Gala M" first="Manish" last="Gala">Manish Gala</name><affiliation><nlm:aff id="AF0001"><institution>Gastrointestinal Unit</institution>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation><nlm:aff id="AF0019"><institution>Department of Surgery, University Health Network Toronto General Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>ON</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W." last="Haile">Robert W. Haile</name><affiliation><nlm:aff id="AF0020"><institution>Stanford Cancer Institute</institution>,<addr-line>Palo Alto, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A." last="Harrison">Tabitha A. Harrison</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hayes, Richard" sort="Hayes, Richard" uniqKey="Hayes R" first="Richard" last="Hayes">Richard Hayes</name><affiliation><nlm:aff id="AF0021"><institution>Division of Epidemiology</institution>,<institution>New York University School of Medicine</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><affiliation><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Haiman, Chris" sort="Haiman, Chris" uniqKey="Haiman C" first="Chris" last="Haiman">Chris Haiman</name><affiliation><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation><nlm:aff id="AF0003"><institution>Division of Clinical Epidemiology and Aging Research</institution>,<institution>German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="AF0022"><institution>Melbourne School of Population Health</institution>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name><affiliation><nlm:aff id="AF0021"><institution>Division of Epidemiology</institution>,<institution>New York University School of Medicine</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation><nlm:aff id="AF0023"><institution>Epidemiology Program</institution>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><affiliation><nlm:aff id="AF0010"><institution>CHU Nantes, Service de Génétique Médicale</institution>,<addr-line>Nantes</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loic Le" last="Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="AF0023"><institution>Epidemiology Program</institution>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation><nlm:aff id="AF0024"><institution>Ontario Institute for Cancer Research</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation><nlm:aff id="AF0025"><institution>Department of Health Science Services, Mayo Clinic</institution>,<addr-line>Scottsdale</addr-line>,<addr-line>AZ</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E." last="Manson">Joann E. Manson</name><affiliation><nlm:aff id="AF0026"><institution>Department of Medicine</institution>,<institution>Brigham and Women’s Hospital</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Morikawa, Teppei" sort="Morikawa, Teppei" uniqKey="Morikawa T" first="Teppei" last="Morikawa">Teppei Morikawa</name><affiliation><nlm:aff id="AF0027"><institution>Department of Pathology</institution>,<institution>The University of Tokyo Hospital</institution>,<addr-line>Tokyo</addr-line>,<country>Japan</country>,</nlm:aff></affiliation></author><author><name sortKey="Nan, Hongmei" sort="Nan, Hongmei" uniqKey="Nan H" first="Hongmei" last="Nan">Hongmei Nan</name><affiliation><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ng, Kimmie" sort="Ng, Kimmie" uniqKey="Ng K" first="Kimmie" last="Ng">Kimmie Ng</name><affiliation><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Nishihara, Reiko" sort="Nishihara, Reiko" uniqKey="Nishihara R" first="Reiko" last="Nishihara">Reiko Nishihara</name><affiliation><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0028"><institution>Department of Nutrition, Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0029"><institution>Department of Epidemiology</institution>,<institution>University of Washington</institution>,<addr-line>Seattle</addr-line>,<addr-line>WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0030"><institution>Center for Public Health Research, Massey University</institution>,<addr-line>Wellington</addr-line>,<country>New Zealand</country>,</nlm:aff></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation><nlm:aff id="AF0031"><institution>Department of Medicine and Epidemiology</institution>,<institution>University of Pittsburgh Medical Center</institution>,<addr-line>Pittsburgh</addr-line>,<addr-line>PA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:aff id="AF0006"><institution>Division of Cancer Control and Population Sciences, National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Taverna, Darin" sort="Taverna, Darin" uniqKey="Taverna D" first="Darin" last="Taverna">Darin Taverna</name><affiliation><nlm:aff id="AF0016"><institution>Systems Imagination, Computational Biology</institution>,<addr-line>Pheonix</addr-line>,<addr-line>AZ</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Thibodeau, Stephen" sort="Thibodeau, Stephen" uniqKey="Thibodeau S" first="Stephen" last="Thibodeau">Stephen Thibodeau</name><affiliation><nlm:aff id="AF0032"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<addr-line>MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><affiliation><nlm:aff id="AF0033"><institution>Department of Social and Preventive Medicine</institution>,<institution>University of Buffalo</institution>,<addr-line>Buffalo</addr-line>,<addr-line>NY</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><affiliation><nlm:aff id="AF0028"><institution>Department of Nutrition, Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W." last="Zanke">Brent W. Zanke</name><affiliation><nlm:aff id="AF0034"><institution>Clinical Epidemiology Program, Ottawa Hospital Research Institute</institution>,<addr-line>Ottawa</addr-line>,<addr-line>ON</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation><nlm:aff id="AF0024"><institution>Ontario Institute for Cancer Research</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0035"><institution>Department of Medical Biophysics</institution>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<addr-line>ON</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="AF0014"><institution>Program in Molecular and Genetic Epidemiology</institution>,<institution>Harvard T.H. Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation><nlm:aff id="AF0036"><institution>Department of Internal Medicine</institution>,<institution>University of Utah Health Sciences Center</institution>,<addr-line>Salt Lake City</addr-line>,<addr-line>UT</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><affiliation><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0037"><institution>Department of Pathology</institution>,<institution>Brigham and Women’s Hospital</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0038"><institution>Department of Epidemiology</institution>,<institution>Harvard T.H. Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation><nlm:aff id="AF0001"><institution>Gastrointestinal Unit</institution>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author></analytic><series><title level="j">Carcinogenesis</title><idno type="ISSN">0143-3334</idno><idno type="eISSN">1460-2180</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>We identified the minor allele (T) in SNP rs11676348 to have pleiotropic effect on risk of UC and CRC, particularly in tumors with an inflammatory component. Our findings offer the promise of risk stratification of UC patients for developing CRC.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Carcinogenesis</journal-id><journal-id journal-id-type="iso-abbrev">Carcinogenesis</journal-id><journal-id journal-id-type="hwp">carcin</journal-id><journal-id journal-id-type="publisher-id">carcin</journal-id><journal-title-group><journal-title>Carcinogenesis</journal-title></journal-title-group><issn pub-type="ppub">0143-3334</issn><issn pub-type="epub">1460-2180</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26071399</article-id><article-id pub-id-type="pmc">4573660</article-id><article-id pub-id-type="doi">10.1093/carcin/bgv086</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Manuscript</subject></subj-group></article-categories><title-group><article-title>Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Khalili</surname><given-names>Hamed</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gong</surname><given-names>Jian</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Hermann</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Austin</surname><given-names>Thomas R.</given-names></name><xref ref-type="aff" rid="AF0005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hutter</surname><given-names>Carolyn M.</given-names></name><xref ref-type="aff" rid="AF0006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Baba</surname><given-names>Yoshifumi</given-names></name><xref ref-type="aff" rid="AF0007"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Baron</surname><given-names>John A.</given-names></name><xref ref-type="aff" rid="AF0008"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Berndt</surname><given-names>Sonja I.</given-names></name><xref ref-type="aff" rid="AF0009"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bézieau</surname><given-names>Stéphane</given-names></name><xref ref-type="aff" rid="AF0010"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Caan</surname><given-names>Bette</given-names></name><xref ref-type="aff" rid="AF0011"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Campbell</surname><given-names>Peter T.</given-names></name><xref ref-type="aff" rid="AF0012"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="AF0013"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chanock</surname><given-names>Stephen J.</given-names></name><xref ref-type="aff" rid="AF0009"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Constance</given-names></name><xref ref-type="aff" rid="AF0014"><sup>14</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hsu</surname><given-names>Li</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jiao</surname><given-names>Shuo</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Conti</surname><given-names>David V.</given-names></name><xref ref-type="aff" rid="AF0015"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Duggan</surname><given-names>David</given-names></name><xref ref-type="aff" rid="AF0016"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fuchs</surname><given-names>Charles S.</given-names></name><xref ref-type="aff" rid="AF0017"><sup>17</sup></xref><xref ref-type="aff" rid="AF0018"><sup>18</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gala</surname><given-names>Manish</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gallinger</surname><given-names>Steven</given-names></name><xref ref-type="aff" rid="AF0019"><sup>19</sup></xref></contrib><contrib contrib-type="author"><name><surname>Haile</surname><given-names>Robert W.</given-names></name><xref ref-type="aff" rid="AF0020"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Harrison</surname><given-names>Tabitha A.</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hayes</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="AF0021"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hazra</surname><given-names>Aditi</given-names></name><xref ref-type="aff" rid="AF0018"><sup>18</sup></xref></contrib><contrib contrib-type="author"><name><surname>Henderson</surname><given-names>Brian</given-names></name><xref ref-type="aff" rid="AF0015"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Haiman</surname><given-names>Chris</given-names></name><xref ref-type="aff" rid="AF0015"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hoffmeister</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><xref ref-type="aff" rid="AF0022"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jenkins</surname><given-names>Mark A.</given-names></name><xref ref-type="aff" rid="AF0021"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kolonel</surname><given-names>Laurence N.</given-names></name><xref ref-type="aff" rid="AF0023"><sup>23</sup></xref></contrib><contrib contrib-type="author"><name><surname>Küry</surname><given-names>Sébastien</given-names></name><xref ref-type="aff" rid="AF0010"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>LaCroix</surname><given-names>Andrea</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Marchand</surname><given-names>Loic Le</given-names></name><xref ref-type="aff" rid="AF0023"><sup>23</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lemire</surname><given-names>Mathieu</given-names></name><xref ref-type="aff" rid="AF0024"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lindor</surname><given-names>Noralane M.</given-names></name><xref ref-type="aff" rid="AF0025"><sup>25</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Jing</given-names></name><xref ref-type="aff" rid="AF0018"><sup>18</sup></xref></contrib><contrib contrib-type="author"><name><surname>Manson</surname><given-names>JoAnn E.</given-names></name><xref ref-type="aff" rid="AF0026"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Morikawa</surname><given-names>Teppei</given-names></name><xref ref-type="aff" rid="AF0027"><sup>27</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nan</surname><given-names>Hongmei</given-names></name><xref ref-type="aff" rid="AF0018"><sup>18</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ng</surname><given-names>Kimmie</given-names></name><xref ref-type="aff" rid="AF0017"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Newcomb</surname><given-names>Polly A.</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nishihara</surname><given-names>Reiko</given-names></name><xref ref-type="aff" rid="AF0017"><sup>17</sup></xref><xref ref-type="aff" rid="AF0028"><sup>28</sup></xref></contrib><contrib contrib-type="author"><name><surname>Potter</surname><given-names>John D.</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref><xref ref-type="aff" rid="AF0029"><sup>29</sup></xref><xref ref-type="aff" rid="AF0030"><sup>30</sup></xref></contrib><contrib contrib-type="author"><name><surname>Qu</surname><given-names>Conghui</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schoen</surname><given-names>Robert E.</given-names></name><xref ref-type="aff" rid="AF0031"><sup>31</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schumacher</surname><given-names>Fredrick R.</given-names></name><xref ref-type="aff" rid="AF0015"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Seminara</surname><given-names>Daniela</given-names></name><xref ref-type="aff" rid="AF0006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Taverna</surname><given-names>Darin</given-names></name><xref ref-type="aff" rid="AF0016"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Thibodeau</surname><given-names>Stephen</given-names></name><xref ref-type="aff" rid="AF0032"><sup>32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wactawski-Wende</surname><given-names>Jean</given-names></name><xref ref-type="aff" rid="AF0033"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>White</surname><given-names>Emily</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Kana</given-names></name><xref ref-type="aff" rid="AF0028"><sup>28</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zanke</surname><given-names>Brent W.</given-names></name><xref ref-type="aff" rid="AF0034"><sup>34</sup></xref></contrib><contrib contrib-type="author"><name><surname>Casey</surname><given-names>Graham</given-names></name><xref ref-type="aff" rid="AF0015"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hudson</surname><given-names>Thomas J.</given-names></name><xref ref-type="aff" rid="AF0024"><sup>24</sup></xref><xref ref-type="aff" rid="AF0035"><sup>35</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kraft</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="AF0014"><sup>14</sup></xref><xref ref-type="aff" rid="AF0018"><sup>18</sup></xref></contrib><contrib contrib-type="author"><name><surname>Peters</surname><given-names>Ulrike</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Slattery</surname><given-names>Martha L.</given-names></name><xref ref-type="aff" rid="AF0036"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ogino</surname><given-names>Shuji</given-names></name><xref ref-type="aff" rid="AF0017"><sup>17</sup></xref><xref ref-type="aff" rid="AF0037"><sup>37</sup></xref><xref ref-type="aff" rid="AF0038"><sup>38</sup></xref><xref ref-type="corresp" rid="c1">*</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Andrew T.</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref><xref ref-type="aff" rid="AF0018"><sup>18</sup></xref><xref ref-type="corresp" rid="c1">*</xref></contrib><on-behalf-of>GECCO and CCFR</on-behalf-of><aff id="AF0001"><sup>1</sup><institution>Gastrointestinal Unit</institution>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="AF0002"><sup>2</sup><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</aff><aff id="AF0003"><sup>3</sup><institution>Division of Clinical Epidemiology and Aging Research</institution>,<institution>German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="AF0004"><sup>4</sup><institution>German Cancer Cosortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="AF0005"><sup>5</sup><institution>Whitman College</institution>,<addr-line>Walla Walla, WA</addr-line>,<country>USA</country>,</aff><aff id="AF0006"><sup>6</sup><institution>Division of Cancer Control and Population Sciences, National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</aff><aff id="AF0007"><sup>7</sup><institution>Department of Gastroenterological Surgery</institution>,<institution>Kumamoto University</institution>,<addr-line>Kumamoto</addr-line>,<country>Japan</country>,</aff><aff id="AF0008"><sup>8</sup><institution>Department of Medicine, School of Medicine</institution>,<institution>University of North Carolina</institution>,<addr-line>Chapel Hill</addr-line>,<addr-line>NC</addr-line>,<country>USA</country>,</aff><aff id="AF0009"><sup>9</sup><institution>Division of Cancer Epidemiology and Genetics</institution>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</aff><aff id="AF0010"><sup>10</sup><institution>CHU Nantes, Service de Génétique Médicale</institution>,<addr-line>Nantes</addr-line>,<country>France</country>,</aff><aff id="AF0011"><sup>11</sup><institution>Division of Hematology</institution>,<institution>Faculty of Medicine</institution>,<institution>The University of Ottawa</institution>,<addr-line>Ottawa</addr-line>,<addr-line>ON</addr-line>,<country>Canada</country>,</aff><aff id="AF0012"><sup>12</sup><institution>Epidemiology Research Program, American Cancer Society</institution>,<addr-line>Atlanta</addr-line>,<addr-line>GA</addr-line>,<country>USA</country>,</aff><aff id="AF0013"><sup>13</sup><institution>Division of Cancer Epidemiology</institution>,<institution>German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="AF0014"><sup>14</sup><institution>Program in Molecular and Genetic Epidemiology</institution>,<institution>Harvard T.H. Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</aff><aff id="AF0015"><sup>15</sup><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</aff><aff id="AF0016"><sup>16</sup><institution>Systems Imagination, Computational Biology</institution>,<addr-line>Pheonix</addr-line>,<addr-line>AZ</addr-line>,<country>USA</country>,</aff><aff id="AF0017"><sup>17</sup><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="AF0018"><sup>18</sup><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</aff><aff id="AF0019"><sup>19</sup><institution>Department of Surgery, University Health Network Toronto General Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>ON</addr-line>,<country>Canada</country>,</aff><aff id="AF0020"><sup>20</sup><institution>Stanford Cancer Institute</institution>,<addr-line>Palo Alto, CA</addr-line>,<country>USA</country>,</aff><aff id="AF0021"><sup>21</sup><institution>Division of Epidemiology</institution>,<institution>New York University School of Medicine</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</aff><aff id="AF0022"><sup>22</sup><institution>Melbourne School of Population Health</institution>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</aff><aff id="AF0023"><sup>23</sup><institution>Epidemiology Program</institution>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</aff><aff id="AF0024"><sup>24</sup><institution>Ontario Institute for Cancer Research</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country>,</aff><aff id="AF0025"><sup>25</sup><institution>Department of Health Science Services, Mayo Clinic</institution>,<addr-line>Scottsdale</addr-line>,<addr-line>AZ</addr-line>,<country>USA</country>,</aff><aff id="AF0026"><sup>26</sup><institution>Department of Medicine</institution>,<institution>Brigham and Women’s Hospital</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</aff><aff id="AF0027"><sup>27</sup><institution>Department of Pathology</institution>,<institution>The University of Tokyo Hospital</institution>,<addr-line>Tokyo</addr-line>,<country>Japan</country>,</aff><aff id="AF0028"><sup>28</sup><institution>Department of Nutrition, Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</aff><aff id="AF0029"><sup>29</sup><institution>Department of Epidemiology</institution>,<institution>University of Washington</institution>,<addr-line>Seattle</addr-line>,<addr-line>WA</addr-line>,<country>USA</country>,</aff><aff id="AF0030"><sup>30</sup><institution>Center for Public Health Research, Massey University</institution>,<addr-line>Wellington</addr-line>,<country>New Zealand</country>,</aff><aff id="AF0031"><sup>31</sup><institution>Department of Medicine and Epidemiology</institution>,<institution>University of Pittsburgh Medical Center</institution>,<addr-line>Pittsburgh</addr-line>,<addr-line>PA</addr-line>,<country>USA</country>,</aff><aff id="AF0032"><sup>32</sup><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<addr-line>MN</addr-line>,<country>USA</country>,</aff><aff id="AF0033"><sup>33</sup><institution>Department of Social and Preventive Medicine</institution>,<institution>University of Buffalo</institution>,<addr-line>Buffalo</addr-line>,<addr-line>NY</addr-line>,<country>USA</country>,</aff><aff id="AF0034"><sup>34</sup><institution>Clinical Epidemiology Program, Ottawa Hospital Research Institute</institution>,<addr-line>Ottawa</addr-line>,<addr-line>ON</addr-line>,<country>USA</country>,</aff><aff id="AF0035"><sup>35</sup><institution>Department of Medical Biophysics</institution>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<addr-line>ON</addr-line>,<country>USA</country>,</aff><aff id="AF0036"><sup>36</sup><institution>Department of Internal Medicine</institution>,<institution>University of Utah Health Sciences Center</institution>,<addr-line>Salt Lake City</addr-line>,<addr-line>UT</addr-line>,<country>USA</country>,</aff><aff id="AF0037"><sup>37</sup><institution>Department of Pathology</institution>,<institution>Brigham and Women’s Hospital</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</aff><aff id="AF0038"><sup>38</sup><institution>Department of Epidemiology</institution>,<institution>Harvard T.H. Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country></aff></contrib-group><author-notes><corresp id="c1">*To whom correspondence should be addressed. Tel: +<phone>1 617 724 0283</phone>; Fax: +<fax>1 617 726 3673</fax>; Email: <email>achan@mgh.harvard.edu</email>, Correspondence may also be addressed to Shuji Ogino; Tel: +1 617 582 8558; Fax: +1 617 632 1972; Email: <email>shuji_ogino@dfci.harvard.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>9</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>12</day><month>6</month><year>2015</year></pub-date><volume>36</volume><issue>9</issue><fpage>999</fpage><lpage>1007</lpage><history><date date-type="received"><day>29</day><month>3</month><year>2015</year></date><date date-type="accepted"><day>6</day><month>6</month><year>2015</year></date><date date-type="rev-recd"><day>10</day><month>5</month><year>2015</year></date></history><permissions><copyright-statement>© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract abstract-type="precis"><title>Summary</title><p>We identified the minor allele (T) in SNP rs11676348 to have pleiotropic effect on risk of UC and CRC, particularly in tumors with an inflammatory component. Our findings offer the promise of risk stratification of UC patients for developing CRC.</p></abstract><abstract><p>Although genome-wide association studies (GWAS) have separately identified many genetic susceptibility loci for ulcerative colitis (UC), Crohn’s disease (CD) and colorectal cancer (CRC), there has been no large-scale examination for pleiotropy, or shared genetic susceptibility, for these conditions. We used logistic regression modeling to examine the associations of 181 UC and CD susceptibility variants previously identified by GWAS with risk of CRC using data from the Genetics and Epidemiology of Colorectal Cancer Consortium and the Colon Cancer Family Registry. We also examined associations of significant variants with clinical and molecular characteristics in a subset of the studies. Among 11794 CRC cases and 14190 controls, rs11676348, the susceptibility single nucleotide polymorphism (SNP) for UC, was significantly associated with reduced risk of CRC (<italic>P</italic> = 7E−05). The multivariate-adjusted odds ratio of CRC with each copy of the T allele was 0.93 (95% CI 0.89–0.96). The association of the SNP with risk of CRC differed according to mucinous histological features (<italic>P</italic><sub>heterogeneity</sub> = 0.008). In addition, the (T) allele was associated with lower risk of tumors with Crohn’s-like reaction but not tumors without such immune infiltrate (<italic>P</italic><sub>heterogeneity</sub> = 0.02) and microsatellite instability-high (MSI-high) but not microsatellite stable or MSI-low tumors (<italic>P</italic><sub>heterogeneity</sub> = 0.03). The minor allele (T) in SNP rs11676348, located downstream from <italic>CXCR2</italic> that has been implicated in CRC progression, is associated with a lower risk of CRC, particularly tumors with a mucinous component, Crohn’s-like reaction and MSI-high. Our findings offer the promise of risk stratification of inflammatory bowel disease patients for complications such as CRC.</p></abstract><counts><page-count count="9"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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