IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans
Identifieur interne : 000153 ( Pmc/Corpus ); précédent : 000152; suivant : 000154IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans
Auteurs : Neil Pearce ; Aaron Blair ; Paolo Vineis ; Wolfgang Ahrens ; Aage Andersen ; Josep M. Anto ; Bruce K. Armstrong ; Andrea A. Baccarelli ; Frederick A. Beland ; Amy Berrington ; Pier Alberto Bertazzi ; Linda S. Birnbaum ; Ross C. Brownson ; John R. Bucher ; Kenneth P. Cantor ; Elisabeth Cardis ; John W. Cherrie ; David C. Christiani ; Pierluigi Cocco ; David Coggon ; Pietro Comba ; Paul A. Demers ; John M. Dement ; Jeroen Douwes ; Ellen A. Eisen ; Lawrence S. Engel ; Richard A. Fenske ; Lora E. Fleming ; Tony Fletcher ; Elizabeth Fontham ; Francesco Forastiere ; Rainer Frentzel-Beyme ; Lin Fritschi ; Michel Gerin ; Marcel Goldberg ; Philippe Grandjean ; Tom K. Grimsrud ; Per Gustavsson ; Andy Haines ; Patricia Hartge ; Johnni Hansen ; Michael Hauptmann ; Dick Heederik ; Kari Hemminki ; Denis Hemon ; Irva Hertz-Picciotto ; Jane A. Hoppin ; James Huff ; Bengt Jarvholm ; Daehee Kang ; Margaret R. Karagas ; Kristina Kjaerheim ; Helge Kjuus ; Manolis Kogevinas ; David Kriebel ; Petter Kristensen ; Hans Kromhout ; Francine Laden ; Pierre Lebailly ; Grace Lemasters ; Jay H. Lubin ; Charles F. Lynch ; Elsebeth Lynge ; Andrea Mannetje ; Anthony J. Mcmichael ; John R. Mclaughlin ; Loraine Marrett ; Marco Martuzzi ; James A. Merchant ; Enzo Merler ; Franco Merletti ; Anthony Miller ; Franklin E. Mirer ; Richard Monson ; Karl-Cristian Nordby ; Andrew F. Olshan ; Marie-Elise Parent ; Frederica P. Perera ; Melissa J. Perry ; Angela Cecilia Pesatori ; Roberta Pirastu ; Miquel Porta ; Eero Pukkala ; Carol Rice ; David B. Richardson ; Leonard Ritter ; Beate Ritz ; Cecile M. Ronckers ; Lesley Rushton ; Jennifer A. Rusiecki ; Ivan Rusyn ; Jonathan M. Samet ; Dale P. Sandler ; Silvia De Sanjose ; Eva Schernhammer ; Adele Seniori Costantini ; Noah Seixas ; Carl Shy ; Jack Siemiatycki ; Debra T. Silverman ; Lorenzo Simonato ; Allan H. Smith ; Martyn T. Smith ; John J. Spinelli ; Margaret R. Spitz ; Lorann Stallones ; Leslie T. Stayner ; Kyle Steenland ; Mark Stenzel ; Bernard W. Stewart ; Patricia A. Stewart ; Elaine Symanski ; Benedetto Terracini ; Paige E. Tolbert ; Harri Vainio ; John Vena ; Roel Vermeulen ; Cesar G. Victora ; Elizabeth M. Ward ; Clarice R. Weinberg ; Dennis Weisenburger ; Catharina Wesseling ; Elisabete Weiderpass ; Shelia Hoar ZahmSource :
- Environmental Health Perspectives [ 0091-6765 ] ; 2015.
Abstract
Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used to perform these evaluations. Some critics have claimed that failures of IARC Working Groups to recognize study weaknesses and biases of Working Group members have led to inappropriate classification of a number of agents as carcinogenic to humans.
Objectives: The authors of this Commentary are scientists from various disciplines relevant to the identification and hazard evaluation of human carcinogens. We examined criticisms of the IARC classification process to determine the validity of these concerns. Here, we present the results of that examination, review the history of IARC evaluations, and describe how the IARC evaluations are performed.
Discussion: We concluded that these recent criticisms are unconvincing. The procedures employed by IARC to assemble Working Groups of scientists from the various disciplines and the techniques followed to review the literature and perform hazard assessment of various agents provide a balanced evaluation and an appropriate indication of the weight of the evidence. Some disagreement by individual scientists to some evaluations is not evidence of process failure. The review process has been modified over time and will undoubtedly be altered in the future to improve the process. Any process can in theory be improved, and we would support continued review and improvement of the IARC processes. This does not mean, however, that the current procedures are flawed.
Conclusions: The IARC Monographs have made, and continue to make, major contributions to the scientific underpinning for societal actions to improve the public’s health.
Citation: Pearce N, Blair A, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli AA, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, ‘t Mannetje A, McMichael AJ, McLaughlin JR, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer FE, Monson R, Nordby KC, Olshan AF, Parent ME, Perera FP, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Seniori Costantini A, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L, Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart PA, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger D, Wesseling C, Weiderpass E, Zahm SH. 2015. IARC Monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect 123:507–514;
Url:
DOI: 10.1289/ehp.1409149
PubMed: 25712798
PubMed Central: 4455595
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans</title><author><name sortKey="Pearce, Neil" sort="Pearce, Neil" uniqKey="Pearce N" first="Neil" last="Pearce">Neil Pearce</name><affiliation><nlm:aff id="aff1"><addr-line>Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Blair, Aaron" sort="Blair, Aaron" uniqKey="Blair A" first="Aaron" last="Blair">Aaron Blair</name><affiliation><nlm:aff id="aff2"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation><nlm:aff id="aff3"><addr-line>Imperial College, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ahrens, Wolfgang" sort="Ahrens, Wolfgang" uniqKey="Ahrens W" first="Wolfgang" last="Ahrens">Wolfgang Ahrens</name><affiliation><nlm:aff id="aff4"><addr-line>Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Andersen, Aage" sort="Andersen, Aage" uniqKey="Andersen A" first="Aage" last="Andersen">Aage Andersen</name><affiliation><nlm:aff id="aff5"><addr-line>Department of Research, Cancer Registry of Norway, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Anto, Josep M" sort="Anto, Josep M" uniqKey="Anto J" first="Josep M." last="Anto">Josep M. Anto</name><affiliation><nlm:aff id="aff6"><addr-line>Centre for Research in Environmental Epidemiology (CREAL), IMIM (Hospital del Mar Medical Research Institute), Universitat Pompeu Fabra (UPF), and CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name><affiliation><nlm:aff id="aff7"><addr-line>School of Public Health, The University of Sydney and Sax Institute, Sydney, New South Wales, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Baccarelli, Andrea A" sort="Baccarelli, Andrea A" uniqKey="Baccarelli A" first="Andrea A." last="Baccarelli">Andrea A. Baccarelli</name><affiliation><nlm:aff id="aff8"><addr-line>Department of Environmental Health, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beland, Frederick A" sort="Beland, Frederick A" uniqKey="Beland F" first="Frederick A." last="Beland">Frederick A. Beland</name><affiliation><nlm:aff id="aff9"><addr-line>Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Berrington, Amy" sort="Berrington, Amy" uniqKey="Berrington A" first="Amy" last="Berrington">Amy Berrington</name><affiliation><nlm:aff id="aff2"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bertazzi, Pier Alberto" sort="Bertazzi, Pier Alberto" uniqKey="Bertazzi P" first="Pier Alberto" last="Bertazzi">Pier Alberto Bertazzi</name><affiliation><nlm:aff id="aff10"><addr-line>Department of Clinical Sciences and Community Health, University of Milan and IRCCS Foundation Ca’Granda Ospedale Maggiore Policlinico, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Birnbaum, Linda S" sort="Birnbaum, Linda S" uniqKey="Birnbaum L" first="Linda S." last="Birnbaum">Linda S. Birnbaum</name><affiliation><nlm:aff id="aff11"><addr-line>NCI, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brownson, Ross C" sort="Brownson, Ross C" uniqKey="Brownson R" first="Ross C." last="Brownson">Ross C. Brownson</name><affiliation><nlm:aff id="aff12"><addr-line>Division of Public Health Sciences, and Alvin J. Siteman Cancer Center, Washington University, School of Medicine, St. Louis, Missouri, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bucher, John R" sort="Bucher, John R" uniqKey="Bucher J" first="John R." last="Bucher">John R. Bucher</name><affiliation><nlm:aff id="aff13"><addr-line>Division of the National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cantor, Kenneth P" sort="Cantor, Kenneth P" uniqKey="Cantor K" first="Kenneth P." last="Cantor">Kenneth P. Cantor</name><affiliation><nlm:aff id="aff14"><addr-line>KP Cantor Environmental LLC, Silver Spring, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cardis, Elisabeth" sort="Cardis, Elisabeth" uniqKey="Cardis E" first="Elisabeth" last="Cardis">Elisabeth Cardis</name><affiliation><nlm:aff id="aff15"><addr-line>CREAL, IMIM, and CIBERESP, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cherrie, John W" sort="Cherrie, John W" uniqKey="Cherrie J" first="John W." last="Cherrie">John W. Cherrie</name><affiliation><nlm:aff id="aff16"><addr-line>Institute of Occupational Medicine, Edinburgh, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C." last="Christiani">David C. Christiani</name><affiliation><nlm:aff id="aff8"><addr-line>Department of Environmental Health, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name><affiliation><nlm:aff id="aff17"><addr-line>Department of Public Health, Clinical and Molecular Medicine, University of Cagliari-Monserrato, Cagliari, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Coggon, David" sort="Coggon, David" uniqKey="Coggon D" first="David" last="Coggon">David Coggon</name><affiliation><nlm:aff id="aff18"><addr-line>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Comba, Pietro" sort="Comba, Pietro" uniqKey="Comba P" first="Pietro" last="Comba">Pietro Comba</name><affiliation><nlm:aff id="aff19"><addr-line>Department of Biology and Biotechnology, “Charles Darwin” Sapienza Rome University, Rome, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Demers, Paul A" sort="Demers, Paul A" uniqKey="Demers P" first="Paul A." last="Demers">Paul A. Demers</name><affiliation><nlm:aff id="aff20"><addr-line>Occupational Cancer Research Centre, Cancer Care Ontario, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dement, John M" sort="Dement, John M" uniqKey="Dement J" first="John M." last="Dement">John M. Dement</name><affiliation><nlm:aff id="aff21"><addr-line>Division of Occupational and Environmental Medicine, Duke University Medical Center, Durham, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Douwes, Jeroen" sort="Douwes, Jeroen" uniqKey="Douwes J" first="Jeroen" last="Douwes">Jeroen Douwes</name><affiliation><nlm:aff id="aff22"><addr-line>Centre for Public Health Research, Massey University, Wellington, New Zealand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Eisen, Ellen A" sort="Eisen, Ellen A" uniqKey="Eisen E" first="Ellen A." last="Eisen">Ellen A. Eisen</name><affiliation><nlm:aff id="aff23"><addr-line>Department of Environmental Health Science, and Department of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Engel, Lawrence S" sort="Engel, Lawrence S" uniqKey="Engel L" first="Lawrence S." last="Engel">Lawrence S. Engel</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fenske, Richard A" sort="Fenske, Richard A" uniqKey="Fenske R" first="Richard A." last="Fenske">Richard A. Fenske</name><affiliation><nlm:aff id="aff25"><addr-line>Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, Washington, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fleming, Lora E" sort="Fleming, Lora E" uniqKey="Fleming L" first="Lora E." last="Fleming">Lora E. Fleming</name><affiliation><nlm:aff id="aff26"><addr-line>European Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fletcher, Tony" sort="Fletcher, Tony" uniqKey="Fletcher T" first="Tony" last="Fletcher">Tony Fletcher</name><affiliation><nlm:aff id="aff27"><addr-line>Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fontham, Elizabeth" sort="Fontham, Elizabeth" uniqKey="Fontham E" first="Elizabeth" last="Fontham">Elizabeth Fontham</name><affiliation><nlm:aff id="aff28"><addr-line>Louisiana State University School of Public Health, New Orleans, Louisiana, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Forastiere, Francesco" sort="Forastiere, Francesco" uniqKey="Forastiere F" first="Francesco" last="Forastiere">Francesco Forastiere</name><affiliation><nlm:aff id="aff29"><addr-line>Department of Epidemiology, Lazio Regional Health Service, Rome, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Frentzel Beyme, Rainer" sort="Frentzel Beyme, Rainer" uniqKey="Frentzel Beyme R" first="Rainer" last="Frentzel-Beyme">Rainer Frentzel-Beyme</name><affiliation><nlm:aff id="aff30"><addr-line>Center for Environmental Research and Sustainable Technology (UFT), Universität Bremen, Bremen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fritschi, Lin" sort="Fritschi, Lin" uniqKey="Fritschi L" first="Lin" last="Fritschi">Lin Fritschi</name><affiliation><nlm:aff id="aff31"><addr-line>School of Public Health, Curtin University, Perth, Western Australia, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gerin, Michel" sort="Gerin, Michel" uniqKey="Gerin M" first="Michel" last="Gerin">Michel Gerin</name><affiliation><nlm:aff id="aff32"><addr-line>Department of Environmental and Occupational Health, Ecole de Santé Publique, Universite de Montreal, Montreal, Quebec, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Goldberg, Marcel" sort="Goldberg, Marcel" uniqKey="Goldberg M" first="Marcel" last="Goldberg">Marcel Goldberg</name><affiliation><nlm:aff id="aff33"><addr-line>Population-based Epidemiological Cohorts Unit, Inserm UMS 011, Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Grandjean, Philippe" sort="Grandjean, Philippe" uniqKey="Grandjean P" first="Philippe" last="Grandjean">Philippe Grandjean</name><affiliation><nlm:aff id="aff34"><addr-line>Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Grimsrud, Tom K" sort="Grimsrud, Tom K" uniqKey="Grimsrud T" first="Tom K." last="Grimsrud">Tom K. Grimsrud</name><affiliation><nlm:aff id="aff5"><addr-line>Department of Research, Cancer Registry of Norway, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gustavsson, Per" sort="Gustavsson, Per" uniqKey="Gustavsson P" first="Per" last="Gustavsson">Per Gustavsson</name><affiliation><nlm:aff id="aff35"><addr-line>Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Haines, Andy" sort="Haines, Andy" uniqKey="Haines A" first="Andy" last="Haines">Andy Haines</name><affiliation><nlm:aff id="aff27"><addr-line>Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name><affiliation><nlm:aff id="aff2"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hansen, Johnni" sort="Hansen, Johnni" uniqKey="Hansen J" first="Johnni" last="Hansen">Johnni Hansen</name><affiliation><nlm:aff id="aff36"><addr-line>Danish Cancer Society Research Center, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hauptmann, Michael" sort="Hauptmann, Michael" uniqKey="Hauptmann M" first="Michael" last="Hauptmann">Michael Hauptmann</name><affiliation><nlm:aff id="aff37"><addr-line>Department of Epidemiology and Biostatistics, Netherlands Cancer Institute, Amsterdam, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Heederik, Dick" sort="Heederik, Dick" uniqKey="Heederik D" first="Dick" last="Heederik">Dick Heederik</name><affiliation><nlm:aff id="aff38"><addr-line>Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hemminki, Kari" sort="Hemminki, Kari" uniqKey="Hemminki K" first="Kari" last="Hemminki">Kari Hemminki</name><affiliation><nlm:aff id="aff39"><addr-line>German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hemon, Denis" sort="Hemon, Denis" uniqKey="Hemon D" first="Denis" last="Hemon">Denis Hemon</name><affiliation><nlm:aff id="aff40"><addr-line>Epidemiology and Biostatistics Sorbonne Paris Cite Center (CRESS), INSERM, UMR 1153, Epidemiology of Childhood and Adolescent Cancers Research Group (EPICEA), Paris Descartes University, F-75015, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hertz Picciotto, Irva" sort="Hertz Picciotto, Irva" uniqKey="Hertz Picciotto I" first="Irva" last="Hertz-Picciotto">Irva Hertz-Picciotto</name><affiliation><nlm:aff id="aff41"><addr-line>Department of Public Health Sciences, University of California, Davis, Davis, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hoppin, Jane A" sort="Hoppin, Jane A" uniqKey="Hoppin J" first="Jane A." last="Hoppin">Jane A. Hoppin</name><affiliation><nlm:aff id="aff42"><addr-line>Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Huff, James" sort="Huff, James" uniqKey="Huff J" first="James" last="Huff">James Huff</name><affiliation><nlm:aff id="aff43"><addr-line>NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jarvholm, Bengt" sort="Jarvholm, Bengt" uniqKey="Jarvholm B" first="Bengt" last="Jarvholm">Bengt Jarvholm</name><affiliation><nlm:aff id="aff44"><addr-line>Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="aff45"><addr-line>College of Medicine, Seoul National University, Seoul, Korea</addr-line></nlm:aff></affiliation></author><author><name sortKey="Karagas, Margaret R" sort="Karagas, Margaret R" uniqKey="Karagas M" first="Margaret R." last="Karagas">Margaret R. Karagas</name><affiliation><nlm:aff id="aff46"><addr-line>Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kjaerheim, Kristina" sort="Kjaerheim, Kristina" uniqKey="Kjaerheim K" first="Kristina" last="Kjaerheim">Kristina Kjaerheim</name><affiliation><nlm:aff id="aff5"><addr-line>Department of Research, Cancer Registry of Norway, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kjuus, Helge" sort="Kjuus, Helge" uniqKey="Kjuus H" first="Helge" last="Kjuus">Helge Kjuus</name><affiliation><nlm:aff id="aff47"><addr-line>National Institute of Occupational Health, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation><nlm:aff id="aff48"><addr-line>CREAL, IMIM, and CIBERESP, Barcelona, Spain; National School of Public Health, Athens Greece</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kriebel, David" sort="Kriebel, David" uniqKey="Kriebel D" first="David" last="Kriebel">David Kriebel</name><affiliation><nlm:aff id="aff49"><addr-line>Department of Work Environment, University of Massachusetts Lowell, Lowell, Massachusetts, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kristensen, Petter" sort="Kristensen, Petter" uniqKey="Kristensen P" first="Petter" last="Kristensen">Petter Kristensen</name><affiliation><nlm:aff id="aff47"><addr-line>National Institute of Occupational Health, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kromhout, Hans" sort="Kromhout, Hans" uniqKey="Kromhout H" first="Hans" last="Kromhout">Hans Kromhout</name><affiliation><nlm:aff id="aff38"><addr-line>Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Laden, Francine" sort="Laden, Francine" uniqKey="Laden F" first="Francine" last="Laden">Francine Laden</name><affiliation><nlm:aff id="aff8"><addr-line>Department of Environmental Health, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lebailly, Pierre" sort="Lebailly, Pierre" uniqKey="Lebailly P" first="Pierre" last="Lebailly">Pierre Lebailly</name><affiliation><nlm:aff id="aff50"><addr-line>Centre Francois Baclesse, Universite de Caen, Caen, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lemasters, Grace" sort="Lemasters, Grace" uniqKey="Lemasters G" first="Grace" last="Lemasters">Grace Lemasters</name><affiliation><nlm:aff id="aff51"><addr-line>Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lubin, Jay H" sort="Lubin, Jay H" uniqKey="Lubin J" first="Jay H." last="Lubin">Jay H. Lubin</name><affiliation><nlm:aff id="aff2"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lynch, Charles F" sort="Lynch, Charles F" uniqKey="Lynch C" first="Charles F." last="Lynch">Charles F. Lynch</name><affiliation><nlm:aff id="aff52"><addr-line>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lynge, Elsebeth" sort="Lynge, Elsebeth" uniqKey="Lynge E" first="Elsebeth" last="Lynge">Elsebeth Lynge</name><affiliation><nlm:aff id="aff53"><addr-line>Department of Public Health, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey=" Mannetje, Andrea" sort=" Mannetje, Andrea" uniqKey=" Mannetje A" first="Andrea" last=" Mannetje">Andrea Mannetje</name><affiliation><nlm:aff id="aff22"><addr-line>Centre for Public Health Research, Massey University, Wellington, New Zealand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mcmichael, Anthony J" sort="Mcmichael, Anthony J" uniqKey="Mcmichael A" first="Anthony J." last="Mcmichael">Anthony J. Mcmichael</name><affiliation><nlm:aff id="aff54"><addr-line>National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff101">Deceased</nlm:aff></affiliation></author><author><name sortKey="Mclaughlin, John R" sort="Mclaughlin, John R" uniqKey="Mclaughlin J" first="John R." last="Mclaughlin">John R. Mclaughlin</name><affiliation><nlm:aff id="aff55"><addr-line>Public Health Ontario, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Marrett, Loraine" sort="Marrett, Loraine" uniqKey="Marrett L" first="Loraine" last="Marrett">Loraine Marrett</name><affiliation><nlm:aff id="aff56"><addr-line>Prevention and Cancer Control, Cancer Care Ontario, and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Martuzzi, Marco" sort="Martuzzi, Marco" uniqKey="Martuzzi M" first="Marco" last="Martuzzi">Marco Martuzzi</name><affiliation><nlm:aff id="aff57"><addr-line>World Health Organization Regional Office for Europe, European Centre for Environment and Health, Bonn, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Merchant, James A" sort="Merchant, James A" uniqKey="Merchant J" first="James A." last="Merchant">James A. Merchant</name><affiliation><nlm:aff id="aff52"><addr-line>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Merler, Enzo" sort="Merler, Enzo" uniqKey="Merler E" first="Enzo" last="Merler">Enzo Merler</name><affiliation><nlm:aff id="aff58"><addr-line>Regional Mesothelioma Register, National Health Service, Local Health Authority, Padova, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Merletti, Franco" sort="Merletti, Franco" uniqKey="Merletti F" first="Franco" last="Merletti">Franco Merletti</name><affiliation><nlm:aff id="aff59"><addr-line>Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Miller, Anthony" sort="Miller, Anthony" uniqKey="Miller A" first="Anthony" last="Miller">Anthony Miller</name><affiliation><nlm:aff id="aff60"><addr-line>Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mirer, Franklin E" sort="Mirer, Franklin E" uniqKey="Mirer F" first="Franklin E." last="Mirer">Franklin E. Mirer</name><affiliation><nlm:aff id="aff61"><addr-line>City University of New York (CUNY) School of Public Health, New York, New York, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Monson, Richard" sort="Monson, Richard" uniqKey="Monson R" first="Richard" last="Monson">Richard Monson</name><affiliation><nlm:aff id="aff8"><addr-line>Department of Environmental Health, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nordby, Karl Cristian" sort="Nordby, Karl Cristian" uniqKey="Nordby K" first="Karl-Cristian" last="Nordby">Karl-Cristian Nordby</name><affiliation><nlm:aff id="aff47"><addr-line>National Institute of Occupational Health, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olshan, Andrew F" sort="Olshan, Andrew F" uniqKey="Olshan A" first="Andrew F." last="Olshan">Andrew F. Olshan</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Parent, Marie Elise" sort="Parent, Marie Elise" uniqKey="Parent M" first="Marie-Elise" last="Parent">Marie-Elise Parent</name><affiliation><nlm:aff id="aff62"><addr-line>INRS-Institut Armand-Frappier, Universite du Quebec, Laval, Quebec, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Perera, Frederica P" sort="Perera, Frederica P" uniqKey="Perera F" first="Frederica P." last="Perera">Frederica P. Perera</name><affiliation><nlm:aff id="aff63"><addr-line>Department of Environmental Health Sciences, and Columbia Center for Children’s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Perry, Melissa J" sort="Perry, Melissa J" uniqKey="Perry M" first="Melissa J." last="Perry">Melissa J. Perry</name><affiliation><nlm:aff id="aff64"><addr-line>Department of Environmental and Occupational Health, George Washington University Milken Institute School of Public Health, Washington, DC, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pesatori, Angela Cecilia" sort="Pesatori, Angela Cecilia" uniqKey="Pesatori A" first="Angela Cecilia" last="Pesatori">Angela Cecilia Pesatori</name><affiliation><nlm:aff id="aff10"><addr-line>Department of Clinical Sciences and Community Health, University of Milan and IRCCS Foundation Ca’Granda Ospedale Maggiore Policlinico, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pirastu, Roberta" sort="Pirastu, Roberta" uniqKey="Pirastu R" first="Roberta" last="Pirastu">Roberta Pirastu</name><affiliation><nlm:aff id="aff19"><addr-line>Department of Biology and Biotechnology, “Charles Darwin” Sapienza Rome University, Rome, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Porta, Miquel" sort="Porta, Miquel" uniqKey="Porta M" first="Miquel" last="Porta">Miquel Porta</name><affiliation><nlm:aff id="aff65"><addr-line>IMIM, CIBERESP, and School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pukkala, Eero" sort="Pukkala, Eero" uniqKey="Pukkala E" first="Eero" last="Pukkala">Eero Pukkala</name><affiliation><nlm:aff id="aff66"><addr-line>Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland, and School of Health Sciences, University of Tampere, Tampere, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rice, Carol" sort="Rice, Carol" uniqKey="Rice C" first="Carol" last="Rice">Carol Rice</name><affiliation><nlm:aff id="aff67"><addr-line>Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Richardson, David B" sort="Richardson, David B" uniqKey="Richardson D" first="David B." last="Richardson">David B. Richardson</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ritter, Leonard" sort="Ritter, Leonard" uniqKey="Ritter L" first="Leonard" last="Ritter">Leonard Ritter</name><affiliation><nlm:aff id="aff68"><addr-line>School of Environmental Sciences, Ontario Agricultural College, University of Guelph, Guelph, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name><affiliation><nlm:aff id="aff69"><addr-line>Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, Los Angeles, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ronckers, Cecile M" sort="Ronckers, Cecile M" uniqKey="Ronckers C" first="Cecile M." last="Ronckers">Cecile M. Ronckers</name><affiliation><nlm:aff id="aff70"><addr-line>Department of Pediatric Oncology, Emma Children’s Hospital/Academic Medical Center, Amsterdam, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rushton, Lesley" sort="Rushton, Lesley" uniqKey="Rushton L" first="Lesley" last="Rushton">Lesley Rushton</name><affiliation><nlm:aff id="aff71"><addr-line>MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rusiecki, Jennifer A" sort="Rusiecki, Jennifer A" uniqKey="Rusiecki J" first="Jennifer A." last="Rusiecki">Jennifer A. Rusiecki</name><affiliation><nlm:aff id="aff72"><addr-line>Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rusyn, Ivan" sort="Rusyn, Ivan" uniqKey="Rusyn I" first="Ivan" last="Rusyn">Ivan Rusyn</name><affiliation><nlm:aff id="aff73"><addr-line>Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Samet, Jonathan M" sort="Samet, Jonathan M" uniqKey="Samet J" first="Jonathan M." last="Samet">Jonathan M. Samet</name><affiliation><nlm:aff id="aff74"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sandler, Dale P" sort="Sandler, Dale P" uniqKey="Sandler D" first="Dale P." last="Sandler">Dale P. Sandler</name><affiliation><nlm:aff id="aff75"><addr-line>Epidemiology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjose">Silvia De Sanjose</name><affiliation><nlm:aff id="aff76"><addr-line>Cancer Epidemiology Research Programme, Unit of Infections and Cancer, Bellvitge Biomedical Research Institute (IDIBELL), CIBERESP Catalan Institute of Oncology, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schernhammer, Eva" sort="Schernhammer, Eva" uniqKey="Schernhammer E" first="Eva" last="Schernhammer">Eva Schernhammer</name><affiliation><nlm:aff id="aff8"><addr-line>Department of Environmental Health, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Costantini, Adele Seniori" sort="Costantini, Adele Seniori" uniqKey="Costantini A" first="Adele Seniori" last="Costantini">Adele Seniori Costantini</name><affiliation><nlm:aff id="aff77"><addr-line>Cancer Prevention and Research Institute (ISPO), Florence, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seixas, Noah" sort="Seixas, Noah" uniqKey="Seixas N" first="Noah" last="Seixas">Noah Seixas</name><affiliation><nlm:aff id="aff25"><addr-line>Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, Washington, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shy, Carl" sort="Shy, Carl" uniqKey="Shy C" first="Carl" last="Shy">Carl Shy</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Siemiatycki, Jack" sort="Siemiatycki, Jack" uniqKey="Siemiatycki J" first="Jack" last="Siemiatycki">Jack Siemiatycki</name><affiliation><nlm:aff id="aff78"><addr-line>Department of Social and Preventive Medicine, Ecole de Santé Publique, Universite de Montreal, Montreal, Quebec, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Silverman, Debra T" sort="Silverman, Debra T" uniqKey="Silverman D" first="Debra T." last="Silverman">Debra T. Silverman</name><affiliation><nlm:aff id="aff2"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Simonato, Lorenzo" sort="Simonato, Lorenzo" uniqKey="Simonato L" first="Lorenzo" last="Simonato">Lorenzo Simonato</name><affiliation><nlm:aff id="aff79"><addr-line>Laboratory of Public Health and Population Studies, Department of Molecular Medicine, University of Padova, Padova, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Smith, Allan H" sort="Smith, Allan H" uniqKey="Smith A" first="Allan H." last="Smith">Allan H. Smith</name><affiliation><nlm:aff id="aff80"><addr-line>The School of Public Health, University of California, Berkeley, Berkeley, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Smith, Martyn T" sort="Smith, Martyn T" uniqKey="Smith M" first="Martyn T." last="Smith">Martyn T. Smith</name><affiliation><nlm:aff id="aff81"><addr-line>Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J." last="Spinelli">John J. Spinelli</name><affiliation><nlm:aff id="aff82"><addr-line>Cancer Control Research, BC Cancer Agency and School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Spitz, Margaret R" sort="Spitz, Margaret R" uniqKey="Spitz M" first="Margaret R." last="Spitz">Margaret R. Spitz</name><affiliation><nlm:aff id="aff83"><addr-line>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stallones, Lorann" sort="Stallones, Lorann" uniqKey="Stallones L" first="Lorann" last="Stallones">Lorann Stallones</name><affiliation><nlm:aff id="aff84"><addr-line>Department of Psychology, Colorado State University, Fort Collins, Colorado, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stayner, Leslie T" sort="Stayner, Leslie T" uniqKey="Stayner L" first="Leslie T." last="Stayner">Leslie T. Stayner</name><affiliation><nlm:aff id="aff85"><addr-line>Division of Epidemiology and Biostatistics, University of Illinois at Chicago, School of Public Health, Chicago, Illinois, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Steenland, Kyle" sort="Steenland, Kyle" uniqKey="Steenland K" first="Kyle" last="Steenland">Kyle Steenland</name><affiliation><nlm:aff id="aff86"><addr-line>Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stenzel, Mark" sort="Stenzel, Mark" uniqKey="Stenzel M" first="Mark" last="Stenzel">Mark Stenzel</name><affiliation><nlm:aff id="aff87"><addr-line>Exposure Assessment Applications LLC, Arlington, Virginia, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stewart, Bernard W" sort="Stewart, Bernard W" uniqKey="Stewart B" first="Bernard W." last="Stewart">Bernard W. Stewart</name><affiliation><nlm:aff id="aff88"><addr-line>Cancer Control Program, South East Sydney Public Health Unit, Randwick, New South Wales, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stewart, Patricia A" sort="Stewart, Patricia A" uniqKey="Stewart P" first="Patricia A." last="Stewart">Patricia A. Stewart</name><affiliation><nlm:aff id="aff89"><addr-line>Stewart Exposure Assessments LLC, Arlington, Virginia, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Symanski, Elaine" sort="Symanski, Elaine" uniqKey="Symanski E" first="Elaine" last="Symanski">Elaine Symanski</name><affiliation><nlm:aff id="aff90"><addr-line>Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Terracini, Benedetto" sort="Terracini, Benedetto" uniqKey="Terracini B" first="Benedetto" last="Terracini">Benedetto Terracini</name><affiliation><nlm:aff id="aff91"><addr-line>University of Torino and Centro di Riferimento per l’Epidemiologia e la Prevenzione Oncologica, CPO Piemonte, Torino, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tolbert, Paige E" sort="Tolbert, Paige E" uniqKey="Tolbert P" first="Paige E." last="Tolbert">Paige E. Tolbert</name><affiliation><nlm:aff id="aff86"><addr-line>Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vainio, Harri" sort="Vainio, Harri" uniqKey="Vainio H" first="Harri" last="Vainio">Harri Vainio</name><affiliation><nlm:aff id="aff92"><addr-line>Finnish Institute of Occupational Health, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vena, John" sort="Vena, John" uniqKey="Vena J" first="John" last="Vena">John Vena</name><affiliation><nlm:aff id="aff93"><addr-line>Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vermeulen, Roel" sort="Vermeulen, Roel" uniqKey="Vermeulen R" first="Roel" last="Vermeulen">Roel Vermeulen</name><affiliation><nlm:aff id="aff38"><addr-line>Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Victora, Cesar G" sort="Victora, Cesar G" uniqKey="Victora C" first="Cesar G." last="Victora">Cesar G. Victora</name><affiliation><nlm:aff id="aff94"><addr-line>Universdade Federal de Pelotas, Rio Grande do Sul, Brazil</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ward, Elizabeth M" sort="Ward, Elizabeth M" uniqKey="Ward E" first="Elizabeth M." last="Ward">Elizabeth M. Ward</name><affiliation><nlm:aff id="aff95"><addr-line>American Cancer Society Inc., Atlanta, Georgia, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weinberg, Clarice R" sort="Weinberg, Clarice R" uniqKey="Weinberg C" first="Clarice R." last="Weinberg">Clarice R. Weinberg</name><affiliation><nlm:aff id="aff96"><addr-line>Biostatistics and Computational Biology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weisenburger, Dennis" sort="Weisenburger, Dennis" uniqKey="Weisenburger D" first="Dennis" last="Weisenburger">Dennis Weisenburger</name><affiliation><nlm:aff id="aff97"><addr-line>Department of Pathology, City of Hope National Medical Center, Duarte, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wesseling, Catharina" sort="Wesseling, Catharina" uniqKey="Wesseling C" first="Catharina" last="Wesseling">Catharina Wesseling</name><affiliation><nlm:aff id="aff98"><addr-line>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:aff id="aff99"><addr-line>Department of Community Medicine, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway; Cancer Registry of Norway, Oslo, Norway; Genetic Epidemiology Group, Folkhalsan Research Center, Helsinki, Finland; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zahm, Shelia Hoar" sort="Zahm, Shelia Hoar" uniqKey="Zahm S" first="Shelia Hoar" last="Zahm">Shelia Hoar Zahm</name><affiliation><nlm:aff id="aff100"><addr-line>Shelia Zahm Consulting, Hermon, Maine, USA</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25712798</idno><idno type="pmc">4455595</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455595</idno><idno type="RBID">PMC:4455595</idno><idno type="doi">10.1289/ehp.1409149</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000153</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000153</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans</title><author><name sortKey="Pearce, Neil" sort="Pearce, Neil" uniqKey="Pearce N" first="Neil" last="Pearce">Neil Pearce</name><affiliation><nlm:aff id="aff1"><addr-line>Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Blair, Aaron" sort="Blair, Aaron" uniqKey="Blair A" first="Aaron" last="Blair">Aaron Blair</name><affiliation><nlm:aff id="aff2"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation><nlm:aff id="aff3"><addr-line>Imperial College, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ahrens, Wolfgang" sort="Ahrens, Wolfgang" uniqKey="Ahrens W" first="Wolfgang" last="Ahrens">Wolfgang Ahrens</name><affiliation><nlm:aff id="aff4"><addr-line>Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Andersen, Aage" sort="Andersen, Aage" uniqKey="Andersen A" first="Aage" last="Andersen">Aage Andersen</name><affiliation><nlm:aff id="aff5"><addr-line>Department of Research, Cancer Registry of Norway, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Anto, Josep M" sort="Anto, Josep M" uniqKey="Anto J" first="Josep M." last="Anto">Josep M. Anto</name><affiliation><nlm:aff id="aff6"><addr-line>Centre for Research in Environmental Epidemiology (CREAL), IMIM (Hospital del Mar Medical Research Institute), Universitat Pompeu Fabra (UPF), and CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name><affiliation><nlm:aff id="aff7"><addr-line>School of Public Health, The University of Sydney and Sax Institute, Sydney, New South Wales, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Baccarelli, Andrea A" sort="Baccarelli, Andrea A" uniqKey="Baccarelli A" first="Andrea A." last="Baccarelli">Andrea A. Baccarelli</name><affiliation><nlm:aff id="aff8"><addr-line>Department of Environmental Health, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beland, Frederick A" sort="Beland, Frederick A" uniqKey="Beland F" first="Frederick A." last="Beland">Frederick A. Beland</name><affiliation><nlm:aff id="aff9"><addr-line>Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Berrington, Amy" sort="Berrington, Amy" uniqKey="Berrington A" first="Amy" last="Berrington">Amy Berrington</name><affiliation><nlm:aff id="aff2"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bertazzi, Pier Alberto" sort="Bertazzi, Pier Alberto" uniqKey="Bertazzi P" first="Pier Alberto" last="Bertazzi">Pier Alberto Bertazzi</name><affiliation><nlm:aff id="aff10"><addr-line>Department of Clinical Sciences and Community Health, University of Milan and IRCCS Foundation Ca’Granda Ospedale Maggiore Policlinico, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Birnbaum, Linda S" sort="Birnbaum, Linda S" uniqKey="Birnbaum L" first="Linda S." last="Birnbaum">Linda S. Birnbaum</name><affiliation><nlm:aff id="aff11"><addr-line>NCI, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brownson, Ross C" sort="Brownson, Ross C" uniqKey="Brownson R" first="Ross C." last="Brownson">Ross C. Brownson</name><affiliation><nlm:aff id="aff12"><addr-line>Division of Public Health Sciences, and Alvin J. Siteman Cancer Center, Washington University, School of Medicine, St. Louis, Missouri, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bucher, John R" sort="Bucher, John R" uniqKey="Bucher J" first="John R." last="Bucher">John R. Bucher</name><affiliation><nlm:aff id="aff13"><addr-line>Division of the National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cantor, Kenneth P" sort="Cantor, Kenneth P" uniqKey="Cantor K" first="Kenneth P." last="Cantor">Kenneth P. Cantor</name><affiliation><nlm:aff id="aff14"><addr-line>KP Cantor Environmental LLC, Silver Spring, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cardis, Elisabeth" sort="Cardis, Elisabeth" uniqKey="Cardis E" first="Elisabeth" last="Cardis">Elisabeth Cardis</name><affiliation><nlm:aff id="aff15"><addr-line>CREAL, IMIM, and CIBERESP, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cherrie, John W" sort="Cherrie, John W" uniqKey="Cherrie J" first="John W." last="Cherrie">John W. Cherrie</name><affiliation><nlm:aff id="aff16"><addr-line>Institute of Occupational Medicine, Edinburgh, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C." last="Christiani">David C. Christiani</name><affiliation><nlm:aff id="aff8"><addr-line>Department of Environmental Health, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name><affiliation><nlm:aff id="aff17"><addr-line>Department of Public Health, Clinical and Molecular Medicine, University of Cagliari-Monserrato, Cagliari, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Coggon, David" sort="Coggon, David" uniqKey="Coggon D" first="David" last="Coggon">David Coggon</name><affiliation><nlm:aff id="aff18"><addr-line>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Comba, Pietro" sort="Comba, Pietro" uniqKey="Comba P" first="Pietro" last="Comba">Pietro Comba</name><affiliation><nlm:aff id="aff19"><addr-line>Department of Biology and Biotechnology, “Charles Darwin” Sapienza Rome University, Rome, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Demers, Paul A" sort="Demers, Paul A" uniqKey="Demers P" first="Paul A." last="Demers">Paul A. Demers</name><affiliation><nlm:aff id="aff20"><addr-line>Occupational Cancer Research Centre, Cancer Care Ontario, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dement, John M" sort="Dement, John M" uniqKey="Dement J" first="John M." last="Dement">John M. Dement</name><affiliation><nlm:aff id="aff21"><addr-line>Division of Occupational and Environmental Medicine, Duke University Medical Center, Durham, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Douwes, Jeroen" sort="Douwes, Jeroen" uniqKey="Douwes J" first="Jeroen" last="Douwes">Jeroen Douwes</name><affiliation><nlm:aff id="aff22"><addr-line>Centre for Public Health Research, Massey University, Wellington, New Zealand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Eisen, Ellen A" sort="Eisen, Ellen A" uniqKey="Eisen E" first="Ellen A." last="Eisen">Ellen A. Eisen</name><affiliation><nlm:aff id="aff23"><addr-line>Department of Environmental Health Science, and Department of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Engel, Lawrence S" sort="Engel, Lawrence S" uniqKey="Engel L" first="Lawrence S." last="Engel">Lawrence S. Engel</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fenske, Richard A" sort="Fenske, Richard A" uniqKey="Fenske R" first="Richard A." last="Fenske">Richard A. Fenske</name><affiliation><nlm:aff id="aff25"><addr-line>Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, Washington, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fleming, Lora E" sort="Fleming, Lora E" uniqKey="Fleming L" first="Lora E." last="Fleming">Lora E. Fleming</name><affiliation><nlm:aff id="aff26"><addr-line>European Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fletcher, Tony" sort="Fletcher, Tony" uniqKey="Fletcher T" first="Tony" last="Fletcher">Tony Fletcher</name><affiliation><nlm:aff id="aff27"><addr-line>Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fontham, Elizabeth" sort="Fontham, Elizabeth" uniqKey="Fontham E" first="Elizabeth" last="Fontham">Elizabeth Fontham</name><affiliation><nlm:aff id="aff28"><addr-line>Louisiana State University School of Public Health, New Orleans, Louisiana, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Forastiere, Francesco" sort="Forastiere, Francesco" uniqKey="Forastiere F" first="Francesco" last="Forastiere">Francesco Forastiere</name><affiliation><nlm:aff id="aff29"><addr-line>Department of Epidemiology, Lazio Regional Health Service, Rome, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Frentzel Beyme, Rainer" sort="Frentzel Beyme, Rainer" uniqKey="Frentzel Beyme R" first="Rainer" last="Frentzel-Beyme">Rainer Frentzel-Beyme</name><affiliation><nlm:aff id="aff30"><addr-line>Center for Environmental Research and Sustainable Technology (UFT), Universität Bremen, Bremen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fritschi, Lin" sort="Fritschi, Lin" uniqKey="Fritschi L" first="Lin" last="Fritschi">Lin Fritschi</name><affiliation><nlm:aff id="aff31"><addr-line>School of Public Health, Curtin University, Perth, Western Australia, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gerin, Michel" sort="Gerin, Michel" uniqKey="Gerin M" first="Michel" last="Gerin">Michel Gerin</name><affiliation><nlm:aff id="aff32"><addr-line>Department of Environmental and Occupational Health, Ecole de Santé Publique, Universite de Montreal, Montreal, Quebec, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Goldberg, Marcel" sort="Goldberg, Marcel" uniqKey="Goldberg M" first="Marcel" last="Goldberg">Marcel Goldberg</name><affiliation><nlm:aff id="aff33"><addr-line>Population-based Epidemiological Cohorts Unit, Inserm UMS 011, Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Grandjean, Philippe" sort="Grandjean, Philippe" uniqKey="Grandjean P" first="Philippe" last="Grandjean">Philippe Grandjean</name><affiliation><nlm:aff id="aff34"><addr-line>Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Grimsrud, Tom K" sort="Grimsrud, Tom K" uniqKey="Grimsrud T" first="Tom K." last="Grimsrud">Tom K. Grimsrud</name><affiliation><nlm:aff id="aff5"><addr-line>Department of Research, Cancer Registry of Norway, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gustavsson, Per" sort="Gustavsson, Per" uniqKey="Gustavsson P" first="Per" last="Gustavsson">Per Gustavsson</name><affiliation><nlm:aff id="aff35"><addr-line>Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Haines, Andy" sort="Haines, Andy" uniqKey="Haines A" first="Andy" last="Haines">Andy Haines</name><affiliation><nlm:aff id="aff27"><addr-line>Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name><affiliation><nlm:aff id="aff2"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hansen, Johnni" sort="Hansen, Johnni" uniqKey="Hansen J" first="Johnni" last="Hansen">Johnni Hansen</name><affiliation><nlm:aff id="aff36"><addr-line>Danish Cancer Society Research Center, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hauptmann, Michael" sort="Hauptmann, Michael" uniqKey="Hauptmann M" first="Michael" last="Hauptmann">Michael Hauptmann</name><affiliation><nlm:aff id="aff37"><addr-line>Department of Epidemiology and Biostatistics, Netherlands Cancer Institute, Amsterdam, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Heederik, Dick" sort="Heederik, Dick" uniqKey="Heederik D" first="Dick" last="Heederik">Dick Heederik</name><affiliation><nlm:aff id="aff38"><addr-line>Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hemminki, Kari" sort="Hemminki, Kari" uniqKey="Hemminki K" first="Kari" last="Hemminki">Kari Hemminki</name><affiliation><nlm:aff id="aff39"><addr-line>German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hemon, Denis" sort="Hemon, Denis" uniqKey="Hemon D" first="Denis" last="Hemon">Denis Hemon</name><affiliation><nlm:aff id="aff40"><addr-line>Epidemiology and Biostatistics Sorbonne Paris Cite Center (CRESS), INSERM, UMR 1153, Epidemiology of Childhood and Adolescent Cancers Research Group (EPICEA), Paris Descartes University, F-75015, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hertz Picciotto, Irva" sort="Hertz Picciotto, Irva" uniqKey="Hertz Picciotto I" first="Irva" last="Hertz-Picciotto">Irva Hertz-Picciotto</name><affiliation><nlm:aff id="aff41"><addr-line>Department of Public Health Sciences, University of California, Davis, Davis, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hoppin, Jane A" sort="Hoppin, Jane A" uniqKey="Hoppin J" first="Jane A." last="Hoppin">Jane A. Hoppin</name><affiliation><nlm:aff id="aff42"><addr-line>Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Huff, James" sort="Huff, James" uniqKey="Huff J" first="James" last="Huff">James Huff</name><affiliation><nlm:aff id="aff43"><addr-line>NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jarvholm, Bengt" sort="Jarvholm, Bengt" uniqKey="Jarvholm B" first="Bengt" last="Jarvholm">Bengt Jarvholm</name><affiliation><nlm:aff id="aff44"><addr-line>Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="aff45"><addr-line>College of Medicine, Seoul National University, Seoul, Korea</addr-line></nlm:aff></affiliation></author><author><name sortKey="Karagas, Margaret R" sort="Karagas, Margaret R" uniqKey="Karagas M" first="Margaret R." last="Karagas">Margaret R. Karagas</name><affiliation><nlm:aff id="aff46"><addr-line>Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kjaerheim, Kristina" sort="Kjaerheim, Kristina" uniqKey="Kjaerheim K" first="Kristina" last="Kjaerheim">Kristina Kjaerheim</name><affiliation><nlm:aff id="aff5"><addr-line>Department of Research, Cancer Registry of Norway, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kjuus, Helge" sort="Kjuus, Helge" uniqKey="Kjuus H" first="Helge" last="Kjuus">Helge Kjuus</name><affiliation><nlm:aff id="aff47"><addr-line>National Institute of Occupational Health, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation><nlm:aff id="aff48"><addr-line>CREAL, IMIM, and CIBERESP, Barcelona, Spain; National School of Public Health, Athens Greece</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kriebel, David" sort="Kriebel, David" uniqKey="Kriebel D" first="David" last="Kriebel">David Kriebel</name><affiliation><nlm:aff id="aff49"><addr-line>Department of Work Environment, University of Massachusetts Lowell, Lowell, Massachusetts, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kristensen, Petter" sort="Kristensen, Petter" uniqKey="Kristensen P" first="Petter" last="Kristensen">Petter Kristensen</name><affiliation><nlm:aff id="aff47"><addr-line>National Institute of Occupational Health, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kromhout, Hans" sort="Kromhout, Hans" uniqKey="Kromhout H" first="Hans" last="Kromhout">Hans Kromhout</name><affiliation><nlm:aff id="aff38"><addr-line>Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Laden, Francine" sort="Laden, Francine" uniqKey="Laden F" first="Francine" last="Laden">Francine Laden</name><affiliation><nlm:aff id="aff8"><addr-line>Department of Environmental Health, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lebailly, Pierre" sort="Lebailly, Pierre" uniqKey="Lebailly P" first="Pierre" last="Lebailly">Pierre Lebailly</name><affiliation><nlm:aff id="aff50"><addr-line>Centre Francois Baclesse, Universite de Caen, Caen, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lemasters, Grace" sort="Lemasters, Grace" uniqKey="Lemasters G" first="Grace" last="Lemasters">Grace Lemasters</name><affiliation><nlm:aff id="aff51"><addr-line>Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lubin, Jay H" sort="Lubin, Jay H" uniqKey="Lubin J" first="Jay H." last="Lubin">Jay H. Lubin</name><affiliation><nlm:aff id="aff2"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lynch, Charles F" sort="Lynch, Charles F" uniqKey="Lynch C" first="Charles F." last="Lynch">Charles F. Lynch</name><affiliation><nlm:aff id="aff52"><addr-line>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lynge, Elsebeth" sort="Lynge, Elsebeth" uniqKey="Lynge E" first="Elsebeth" last="Lynge">Elsebeth Lynge</name><affiliation><nlm:aff id="aff53"><addr-line>Department of Public Health, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff></affiliation></author><author><name sortKey=" Mannetje, Andrea" sort=" Mannetje, Andrea" uniqKey=" Mannetje A" first="Andrea" last=" Mannetje">Andrea Mannetje</name><affiliation><nlm:aff id="aff22"><addr-line>Centre for Public Health Research, Massey University, Wellington, New Zealand</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mcmichael, Anthony J" sort="Mcmichael, Anthony J" uniqKey="Mcmichael A" first="Anthony J." last="Mcmichael">Anthony J. Mcmichael</name><affiliation><nlm:aff id="aff54"><addr-line>National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff101">Deceased</nlm:aff></affiliation></author><author><name sortKey="Mclaughlin, John R" sort="Mclaughlin, John R" uniqKey="Mclaughlin J" first="John R." last="Mclaughlin">John R. Mclaughlin</name><affiliation><nlm:aff id="aff55"><addr-line>Public Health Ontario, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Marrett, Loraine" sort="Marrett, Loraine" uniqKey="Marrett L" first="Loraine" last="Marrett">Loraine Marrett</name><affiliation><nlm:aff id="aff56"><addr-line>Prevention and Cancer Control, Cancer Care Ontario, and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Martuzzi, Marco" sort="Martuzzi, Marco" uniqKey="Martuzzi M" first="Marco" last="Martuzzi">Marco Martuzzi</name><affiliation><nlm:aff id="aff57"><addr-line>World Health Organization Regional Office for Europe, European Centre for Environment and Health, Bonn, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Merchant, James A" sort="Merchant, James A" uniqKey="Merchant J" first="James A." last="Merchant">James A. Merchant</name><affiliation><nlm:aff id="aff52"><addr-line>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Merler, Enzo" sort="Merler, Enzo" uniqKey="Merler E" first="Enzo" last="Merler">Enzo Merler</name><affiliation><nlm:aff id="aff58"><addr-line>Regional Mesothelioma Register, National Health Service, Local Health Authority, Padova, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Merletti, Franco" sort="Merletti, Franco" uniqKey="Merletti F" first="Franco" last="Merletti">Franco Merletti</name><affiliation><nlm:aff id="aff59"><addr-line>Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Miller, Anthony" sort="Miller, Anthony" uniqKey="Miller A" first="Anthony" last="Miller">Anthony Miller</name><affiliation><nlm:aff id="aff60"><addr-line>Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mirer, Franklin E" sort="Mirer, Franklin E" uniqKey="Mirer F" first="Franklin E." last="Mirer">Franklin E. Mirer</name><affiliation><nlm:aff id="aff61"><addr-line>City University of New York (CUNY) School of Public Health, New York, New York, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Monson, Richard" sort="Monson, Richard" uniqKey="Monson R" first="Richard" last="Monson">Richard Monson</name><affiliation><nlm:aff id="aff8"><addr-line>Department of Environmental Health, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nordby, Karl Cristian" sort="Nordby, Karl Cristian" uniqKey="Nordby K" first="Karl-Cristian" last="Nordby">Karl-Cristian Nordby</name><affiliation><nlm:aff id="aff47"><addr-line>National Institute of Occupational Health, Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olshan, Andrew F" sort="Olshan, Andrew F" uniqKey="Olshan A" first="Andrew F." last="Olshan">Andrew F. Olshan</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Parent, Marie Elise" sort="Parent, Marie Elise" uniqKey="Parent M" first="Marie-Elise" last="Parent">Marie-Elise Parent</name><affiliation><nlm:aff id="aff62"><addr-line>INRS-Institut Armand-Frappier, Universite du Quebec, Laval, Quebec, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Perera, Frederica P" sort="Perera, Frederica P" uniqKey="Perera F" first="Frederica P." last="Perera">Frederica P. Perera</name><affiliation><nlm:aff id="aff63"><addr-line>Department of Environmental Health Sciences, and Columbia Center for Children’s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Perry, Melissa J" sort="Perry, Melissa J" uniqKey="Perry M" first="Melissa J." last="Perry">Melissa J. Perry</name><affiliation><nlm:aff id="aff64"><addr-line>Department of Environmental and Occupational Health, George Washington University Milken Institute School of Public Health, Washington, DC, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pesatori, Angela Cecilia" sort="Pesatori, Angela Cecilia" uniqKey="Pesatori A" first="Angela Cecilia" last="Pesatori">Angela Cecilia Pesatori</name><affiliation><nlm:aff id="aff10"><addr-line>Department of Clinical Sciences and Community Health, University of Milan and IRCCS Foundation Ca’Granda Ospedale Maggiore Policlinico, Milan, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pirastu, Roberta" sort="Pirastu, Roberta" uniqKey="Pirastu R" first="Roberta" last="Pirastu">Roberta Pirastu</name><affiliation><nlm:aff id="aff19"><addr-line>Department of Biology and Biotechnology, “Charles Darwin” Sapienza Rome University, Rome, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Porta, Miquel" sort="Porta, Miquel" uniqKey="Porta M" first="Miquel" last="Porta">Miquel Porta</name><affiliation><nlm:aff id="aff65"><addr-line>IMIM, CIBERESP, and School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pukkala, Eero" sort="Pukkala, Eero" uniqKey="Pukkala E" first="Eero" last="Pukkala">Eero Pukkala</name><affiliation><nlm:aff id="aff66"><addr-line>Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland, and School of Health Sciences, University of Tampere, Tampere, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rice, Carol" sort="Rice, Carol" uniqKey="Rice C" first="Carol" last="Rice">Carol Rice</name><affiliation><nlm:aff id="aff67"><addr-line>Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Richardson, David B" sort="Richardson, David B" uniqKey="Richardson D" first="David B." last="Richardson">David B. Richardson</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ritter, Leonard" sort="Ritter, Leonard" uniqKey="Ritter L" first="Leonard" last="Ritter">Leonard Ritter</name><affiliation><nlm:aff id="aff68"><addr-line>School of Environmental Sciences, Ontario Agricultural College, University of Guelph, Guelph, Ontario, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name><affiliation><nlm:aff id="aff69"><addr-line>Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, Los Angeles, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ronckers, Cecile M" sort="Ronckers, Cecile M" uniqKey="Ronckers C" first="Cecile M." last="Ronckers">Cecile M. Ronckers</name><affiliation><nlm:aff id="aff70"><addr-line>Department of Pediatric Oncology, Emma Children’s Hospital/Academic Medical Center, Amsterdam, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rushton, Lesley" sort="Rushton, Lesley" uniqKey="Rushton L" first="Lesley" last="Rushton">Lesley Rushton</name><affiliation><nlm:aff id="aff71"><addr-line>MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rusiecki, Jennifer A" sort="Rusiecki, Jennifer A" uniqKey="Rusiecki J" first="Jennifer A." last="Rusiecki">Jennifer A. Rusiecki</name><affiliation><nlm:aff id="aff72"><addr-line>Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rusyn, Ivan" sort="Rusyn, Ivan" uniqKey="Rusyn I" first="Ivan" last="Rusyn">Ivan Rusyn</name><affiliation><nlm:aff id="aff73"><addr-line>Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Samet, Jonathan M" sort="Samet, Jonathan M" uniqKey="Samet J" first="Jonathan M." last="Samet">Jonathan M. Samet</name><affiliation><nlm:aff id="aff74"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sandler, Dale P" sort="Sandler, Dale P" uniqKey="Sandler D" first="Dale P." last="Sandler">Dale P. Sandler</name><affiliation><nlm:aff id="aff75"><addr-line>Epidemiology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjose">Silvia De Sanjose</name><affiliation><nlm:aff id="aff76"><addr-line>Cancer Epidemiology Research Programme, Unit of Infections and Cancer, Bellvitge Biomedical Research Institute (IDIBELL), CIBERESP Catalan Institute of Oncology, Barcelona, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schernhammer, Eva" sort="Schernhammer, Eva" uniqKey="Schernhammer E" first="Eva" last="Schernhammer">Eva Schernhammer</name><affiliation><nlm:aff id="aff8"><addr-line>Department of Environmental Health, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Costantini, Adele Seniori" sort="Costantini, Adele Seniori" uniqKey="Costantini A" first="Adele Seniori" last="Costantini">Adele Seniori Costantini</name><affiliation><nlm:aff id="aff77"><addr-line>Cancer Prevention and Research Institute (ISPO), Florence, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seixas, Noah" sort="Seixas, Noah" uniqKey="Seixas N" first="Noah" last="Seixas">Noah Seixas</name><affiliation><nlm:aff id="aff25"><addr-line>Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, Washington, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Shy, Carl" sort="Shy, Carl" uniqKey="Shy C" first="Carl" last="Shy">Carl Shy</name><affiliation><nlm:aff id="aff24"><addr-line>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Siemiatycki, Jack" sort="Siemiatycki, Jack" uniqKey="Siemiatycki J" first="Jack" last="Siemiatycki">Jack Siemiatycki</name><affiliation><nlm:aff id="aff78"><addr-line>Department of Social and Preventive Medicine, Ecole de Santé Publique, Universite de Montreal, Montreal, Quebec, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Silverman, Debra T" sort="Silverman, Debra T" uniqKey="Silverman D" first="Debra T." last="Silverman">Debra T. Silverman</name><affiliation><nlm:aff id="aff2"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Simonato, Lorenzo" sort="Simonato, Lorenzo" uniqKey="Simonato L" first="Lorenzo" last="Simonato">Lorenzo Simonato</name><affiliation><nlm:aff id="aff79"><addr-line>Laboratory of Public Health and Population Studies, Department of Molecular Medicine, University of Padova, Padova, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Smith, Allan H" sort="Smith, Allan H" uniqKey="Smith A" first="Allan H." last="Smith">Allan H. Smith</name><affiliation><nlm:aff id="aff80"><addr-line>The School of Public Health, University of California, Berkeley, Berkeley, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Smith, Martyn T" sort="Smith, Martyn T" uniqKey="Smith M" first="Martyn T." last="Smith">Martyn T. Smith</name><affiliation><nlm:aff id="aff81"><addr-line>Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J." last="Spinelli">John J. Spinelli</name><affiliation><nlm:aff id="aff82"><addr-line>Cancer Control Research, BC Cancer Agency and School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Spitz, Margaret R" sort="Spitz, Margaret R" uniqKey="Spitz M" first="Margaret R." last="Spitz">Margaret R. Spitz</name><affiliation><nlm:aff id="aff83"><addr-line>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stallones, Lorann" sort="Stallones, Lorann" uniqKey="Stallones L" first="Lorann" last="Stallones">Lorann Stallones</name><affiliation><nlm:aff id="aff84"><addr-line>Department of Psychology, Colorado State University, Fort Collins, Colorado, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stayner, Leslie T" sort="Stayner, Leslie T" uniqKey="Stayner L" first="Leslie T." last="Stayner">Leslie T. Stayner</name><affiliation><nlm:aff id="aff85"><addr-line>Division of Epidemiology and Biostatistics, University of Illinois at Chicago, School of Public Health, Chicago, Illinois, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Steenland, Kyle" sort="Steenland, Kyle" uniqKey="Steenland K" first="Kyle" last="Steenland">Kyle Steenland</name><affiliation><nlm:aff id="aff86"><addr-line>Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stenzel, Mark" sort="Stenzel, Mark" uniqKey="Stenzel M" first="Mark" last="Stenzel">Mark Stenzel</name><affiliation><nlm:aff id="aff87"><addr-line>Exposure Assessment Applications LLC, Arlington, Virginia, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stewart, Bernard W" sort="Stewart, Bernard W" uniqKey="Stewart B" first="Bernard W." last="Stewart">Bernard W. Stewart</name><affiliation><nlm:aff id="aff88"><addr-line>Cancer Control Program, South East Sydney Public Health Unit, Randwick, New South Wales, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stewart, Patricia A" sort="Stewart, Patricia A" uniqKey="Stewart P" first="Patricia A." last="Stewart">Patricia A. Stewart</name><affiliation><nlm:aff id="aff89"><addr-line>Stewart Exposure Assessments LLC, Arlington, Virginia, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Symanski, Elaine" sort="Symanski, Elaine" uniqKey="Symanski E" first="Elaine" last="Symanski">Elaine Symanski</name><affiliation><nlm:aff id="aff90"><addr-line>Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Terracini, Benedetto" sort="Terracini, Benedetto" uniqKey="Terracini B" first="Benedetto" last="Terracini">Benedetto Terracini</name><affiliation><nlm:aff id="aff91"><addr-line>University of Torino and Centro di Riferimento per l’Epidemiologia e la Prevenzione Oncologica, CPO Piemonte, Torino, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tolbert, Paige E" sort="Tolbert, Paige E" uniqKey="Tolbert P" first="Paige E." last="Tolbert">Paige E. Tolbert</name><affiliation><nlm:aff id="aff86"><addr-line>Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vainio, Harri" sort="Vainio, Harri" uniqKey="Vainio H" first="Harri" last="Vainio">Harri Vainio</name><affiliation><nlm:aff id="aff92"><addr-line>Finnish Institute of Occupational Health, Helsinki, Finland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vena, John" sort="Vena, John" uniqKey="Vena J" first="John" last="Vena">John Vena</name><affiliation><nlm:aff id="aff93"><addr-line>Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vermeulen, Roel" sort="Vermeulen, Roel" uniqKey="Vermeulen R" first="Roel" last="Vermeulen">Roel Vermeulen</name><affiliation><nlm:aff id="aff38"><addr-line>Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands</addr-line></nlm:aff></affiliation></author><author><name sortKey="Victora, Cesar G" sort="Victora, Cesar G" uniqKey="Victora C" first="Cesar G." last="Victora">Cesar G. Victora</name><affiliation><nlm:aff id="aff94"><addr-line>Universdade Federal de Pelotas, Rio Grande do Sul, Brazil</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ward, Elizabeth M" sort="Ward, Elizabeth M" uniqKey="Ward E" first="Elizabeth M." last="Ward">Elizabeth M. Ward</name><affiliation><nlm:aff id="aff95"><addr-line>American Cancer Society Inc., Atlanta, Georgia, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weinberg, Clarice R" sort="Weinberg, Clarice R" uniqKey="Weinberg C" first="Clarice R." last="Weinberg">Clarice R. Weinberg</name><affiliation><nlm:aff id="aff96"><addr-line>Biostatistics and Computational Biology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weisenburger, Dennis" sort="Weisenburger, Dennis" uniqKey="Weisenburger D" first="Dennis" last="Weisenburger">Dennis Weisenburger</name><affiliation><nlm:aff id="aff97"><addr-line>Department of Pathology, City of Hope National Medical Center, Duarte, California, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wesseling, Catharina" sort="Wesseling, Catharina" uniqKey="Wesseling C" first="Catharina" last="Wesseling">Catharina Wesseling</name><affiliation><nlm:aff id="aff98"><addr-line>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:aff id="aff99"><addr-line>Department of Community Medicine, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway; Cancer Registry of Norway, Oslo, Norway; Genetic Epidemiology Group, Folkhalsan Research Center, Helsinki, Finland; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zahm, Shelia Hoar" sort="Zahm, Shelia Hoar" uniqKey="Zahm S" first="Shelia Hoar" last="Zahm">Shelia Hoar Zahm</name><affiliation><nlm:aff id="aff100"><addr-line>Shelia Zahm Consulting, Hermon, Maine, USA</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">Environmental Health Perspectives</title><idno type="ISSN">0091-6765</idno><idno type="eISSN">1552-9924</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used to perform these evaluations. Some critics have claimed that failures of IARC Working Groups to recognize study weaknesses and biases of Working Group members have led to inappropriate classification of a number of agents as carcinogenic to humans.</p><p>Objectives: The authors of this Commentary are scientists from various disciplines relevant to the identification and hazard evaluation of human carcinogens. We examined criticisms of the IARC classification process to determine the validity of these concerns. Here, we present the results of that examination, review the history of IARC evaluations, and describe how the IARC evaluations are performed.</p><p>Discussion: We concluded that these recent criticisms are unconvincing. The procedures employed by IARC to assemble Working Groups of scientists from the various disciplines and the techniques followed to review the literature and perform hazard assessment of various agents provide a balanced evaluation and an appropriate indication of the weight of the evidence. Some disagreement by individual scientists to some evaluations is not evidence of process failure. The review process has been modified over time and will undoubtedly be altered in the future to improve the process. Any process can in theory be improved, and we would support continued review and improvement of the IARC processes. This does not mean, however, that the current procedures are flawed.</p><p>Conclusions: The IARC Monographs have made, and continue to make, major contributions to the scientific underpinning for societal actions to improve the public’s health.</p><p>Citation: Pearce N, Blair A, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli AA, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, ‘t Mannetje A, McMichael AJ, McLaughlin JR, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer FE, Monson R, Nordby KC, Olshan AF, Parent ME, Perera FP, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Seniori Costantini A, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L, Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart PA, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger D, Wesseling C, Weiderpass E, Zahm SH. 2015. IARC Monographs: 40 years of evaluating carcinogenic hazards to humans. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Environ Health Perspect</journal-id><journal-id journal-id-type="iso-abbrev">Environ. Health Perspect</journal-id><journal-id journal-id-type="publisher-id">EHP</journal-id><journal-title-group><journal-title>Environmental Health Perspectives</journal-title></journal-title-group><issn pub-type="ppub">0091-6765</issn><issn pub-type="epub">1552-9924</issn><publisher><publisher-name>NLM-Export</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25712798</article-id><article-id pub-id-type="pmc">4455595</article-id><article-id pub-id-type="publisher-id">ehp.1409149</article-id><article-id pub-id-type="doi">10.1289/ehp.1409149</article-id><article-categories><subj-group subj-group-type="heading"><subject>Commentary</subject></subj-group></article-categories><title-group><article-title>IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Pearce</surname><given-names>Neil</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Blair</surname><given-names>Aaron</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vineis</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ahrens</surname><given-names>Wolfgang</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Andersen</surname><given-names>Aage</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Anto</surname><given-names>Josep M.</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Armstrong</surname><given-names>Bruce K.</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Baccarelli</surname><given-names>Andrea A.</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Beland</surname><given-names>Frederick A.</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Berrington</surname><given-names>Amy</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bertazzi</surname><given-names>Pier Alberto</given-names></name><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Birnbaum</surname><given-names>Linda S.</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brownson</surname><given-names>Ross C.</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bucher</surname><given-names>John R.</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cantor</surname><given-names>Kenneth P.</given-names></name><xref ref-type="aff" rid="aff14"><sup>14</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cardis</surname><given-names>Elisabeth</given-names></name><xref ref-type="aff" rid="aff15"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cherrie</surname><given-names>John W.</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Christiani</surname><given-names>David C.</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cocco</surname><given-names>Pierluigi</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Coggon</surname><given-names>David</given-names></name><xref ref-type="aff" rid="aff18"><sup>18</sup></xref></contrib><contrib contrib-type="author"><name><surname>Comba</surname><given-names>Pietro</given-names></name><xref ref-type="aff" rid="aff19"><sup>19</sup></xref></contrib><contrib contrib-type="author"><name><surname>Demers</surname><given-names>Paul A.</given-names></name><xref ref-type="aff" rid="aff20"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dement</surname><given-names>John M.</given-names></name><xref ref-type="aff" rid="aff21"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Douwes</surname><given-names>Jeroen</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Eisen</surname><given-names>Ellen A.</given-names></name><xref ref-type="aff" rid="aff23"><sup>23</sup></xref></contrib><contrib contrib-type="author"><name><surname>Engel</surname><given-names>Lawrence S.</given-names></name><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fenske</surname><given-names>Richard A.</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fleming</surname><given-names>Lora E.</given-names></name><xref ref-type="aff" rid="aff26"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fletcher</surname><given-names>Tony</given-names></name><xref ref-type="aff" rid="aff27"><sup>27</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fontham</surname><given-names>Elizabeth</given-names></name><xref ref-type="aff" rid="aff28"><sup>28</sup></xref></contrib><contrib contrib-type="author"><name><surname>Forastiere</surname><given-names>Francesco</given-names></name><xref ref-type="aff" rid="aff29"><sup>29</sup></xref></contrib><contrib contrib-type="author"><name><surname>Frentzel-Beyme</surname><given-names>Rainer</given-names></name><xref ref-type="aff" rid="aff30"><sup>30</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fritschi</surname><given-names>Lin</given-names></name><xref ref-type="aff" rid="aff31"><sup>31</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gerin</surname><given-names>Michel</given-names></name><xref ref-type="aff" rid="aff32"><sup>32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Goldberg</surname><given-names>Marcel</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Grandjean</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="aff34"><sup>34</sup></xref></contrib><contrib contrib-type="author"><name><surname>Grimsrud</surname><given-names>Tom K.</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gustavsson</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="aff35"><sup>35</sup></xref></contrib><contrib contrib-type="author"><name><surname>Haines</surname><given-names>Andy</given-names></name><xref ref-type="aff" rid="aff27"><sup>27</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hartge</surname><given-names>Patricia</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hansen</surname><given-names>Johnni</given-names></name><xref ref-type="aff" rid="aff36"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hauptmann</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff37"><sup>37</sup></xref></contrib><contrib contrib-type="author"><name><surname>Heederik</surname><given-names>Dick</given-names></name><xref ref-type="aff" rid="aff38"><sup>38</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hemminki</surname><given-names>Kari</given-names></name><xref ref-type="aff" rid="aff39"><sup>39</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hemon</surname><given-names>Denis</given-names></name><xref ref-type="aff" rid="aff40"><sup>40</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hertz-Picciotto</surname><given-names>Irva</given-names></name><xref ref-type="aff" rid="aff41"><sup>41</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hoppin</surname><given-names>Jane A.</given-names></name><xref ref-type="aff" rid="aff42"><sup>42</sup></xref></contrib><contrib contrib-type="author"><name><surname>Huff</surname><given-names>James</given-names></name><xref ref-type="aff" rid="aff43"><sup>43</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jarvholm</surname><given-names>Bengt</given-names></name><xref ref-type="aff" rid="aff44"><sup>44</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Daehee</given-names></name><xref ref-type="aff" rid="aff45"><sup>45</sup></xref></contrib><contrib contrib-type="author"><name><surname>Karagas</surname><given-names>Margaret R.</given-names></name><xref ref-type="aff" rid="aff46"><sup>46</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kjaerheim</surname><given-names>Kristina</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kjuus</surname><given-names>Helge</given-names></name><xref ref-type="aff" rid="aff47"><sup>47</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kogevinas</surname><given-names>Manolis</given-names></name><xref ref-type="aff" rid="aff48"><sup>48</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kriebel</surname><given-names>David</given-names></name><xref ref-type="aff" rid="aff49"><sup>49</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kristensen</surname><given-names>Petter</given-names></name><xref ref-type="aff" rid="aff47"><sup>47</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kromhout</surname><given-names>Hans</given-names></name><xref ref-type="aff" rid="aff38"><sup>38</sup></xref></contrib><contrib contrib-type="author"><name><surname>Laden</surname><given-names>Francine</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lebailly</surname><given-names>Pierre</given-names></name><xref ref-type="aff" rid="aff50"><sup>50</sup></xref></contrib><contrib contrib-type="author"><name><surname>LeMasters</surname><given-names>Grace</given-names></name><xref ref-type="aff" rid="aff51"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lubin</surname><given-names>Jay H.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lynch</surname><given-names>Charles F.</given-names></name><xref ref-type="aff" rid="aff52"><sup>52</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lynge</surname><given-names>Elsebeth</given-names></name><xref ref-type="aff" rid="aff53"><sup>53</sup></xref></contrib><contrib contrib-type="author"><name><surname>‘t Mannetje</surname><given-names>Andrea</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>McMichael</surname><given-names>Anthony J.</given-names></name><xref ref-type="aff" rid="aff54"><sup>54</sup></xref><xref ref-type="aff" rid="aff101">*</xref></contrib><contrib contrib-type="author"><name><surname>McLaughlin</surname><given-names>John R.</given-names></name><xref ref-type="aff" rid="aff55"><sup>55</sup></xref></contrib><contrib contrib-type="author"><name><surname>Marrett</surname><given-names>Loraine</given-names></name><xref ref-type="aff" rid="aff56"><sup>56</sup></xref></contrib><contrib contrib-type="author"><name><surname>Martuzzi</surname><given-names>Marco</given-names></name><xref ref-type="aff" rid="aff57"><sup>57</sup></xref></contrib><contrib contrib-type="author"><name><surname>Merchant</surname><given-names>James A.</given-names></name><xref ref-type="aff" rid="aff52"><sup>52</sup></xref></contrib><contrib contrib-type="author"><name><surname>Merler</surname><given-names>Enzo</given-names></name><xref ref-type="aff" rid="aff58"><sup>58</sup></xref></contrib><contrib contrib-type="author"><name><surname>Merletti</surname><given-names>Franco</given-names></name><xref ref-type="aff" rid="aff59"><sup>59</sup></xref></contrib><contrib contrib-type="author"><name><surname>Miller</surname><given-names>Anthony</given-names></name><xref ref-type="aff" rid="aff60"><sup>60</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mirer</surname><given-names>Franklin E.</given-names></name><xref ref-type="aff" rid="aff61"><sup>61</sup></xref></contrib><contrib contrib-type="author"><name><surname>Monson</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nordby</surname><given-names>Karl-Cristian</given-names></name><xref ref-type="aff" rid="aff47"><sup>47</sup></xref></contrib><contrib contrib-type="author"><name><surname>Olshan</surname><given-names>Andrew F.</given-names></name><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Parent</surname><given-names>Marie-Elise</given-names></name><xref ref-type="aff" rid="aff62"><sup>62</sup></xref></contrib><contrib contrib-type="author"><name><surname>Perera</surname><given-names>Frederica P.</given-names></name><xref ref-type="aff" rid="aff63"><sup>63</sup></xref></contrib><contrib contrib-type="author"><name><surname>Perry</surname><given-names>Melissa J.</given-names></name><xref ref-type="aff" rid="aff64"><sup>64</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pesatori</surname><given-names>Angela Cecilia</given-names></name><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pirastu</surname><given-names>Roberta</given-names></name><xref ref-type="aff" rid="aff19"><sup>19</sup></xref></contrib><contrib contrib-type="author"><name><surname>Porta</surname><given-names>Miquel</given-names></name><xref ref-type="aff" rid="aff65"><sup>65</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pukkala</surname><given-names>Eero</given-names></name><xref ref-type="aff" rid="aff66"><sup>66</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rice</surname><given-names>Carol</given-names></name><xref ref-type="aff" rid="aff67"><sup>67</sup></xref></contrib><contrib contrib-type="author"><name><surname>Richardson</surname><given-names>David B.</given-names></name><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ritter</surname><given-names>Leonard</given-names></name><xref ref-type="aff" rid="aff68"><sup>68</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ritz</surname><given-names>Beate</given-names></name><xref ref-type="aff" rid="aff69"><sup>69</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ronckers</surname><given-names>Cecile M.</given-names></name><xref ref-type="aff" rid="aff70"><sup>70</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rushton</surname><given-names>Lesley</given-names></name><xref ref-type="aff" rid="aff71"><sup>71</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rusiecki</surname><given-names>Jennifer A.</given-names></name><xref ref-type="aff" rid="aff72"><sup>72</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rusyn</surname><given-names>Ivan</given-names></name><xref ref-type="aff" rid="aff73"><sup>73</sup></xref></contrib><contrib contrib-type="author"><name><surname>Samet</surname><given-names>Jonathan M.</given-names></name><xref ref-type="aff" rid="aff74"><sup>74</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sandler</surname><given-names>Dale P.</given-names></name><xref ref-type="aff" rid="aff75"><sup>75</sup></xref></contrib><contrib contrib-type="author"><name><surname>de Sanjose</surname><given-names>Silvia</given-names></name><xref ref-type="aff" rid="aff76"><sup>76</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schernhammer</surname><given-names>Eva</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Costantini</surname><given-names>Adele Seniori</given-names></name><xref ref-type="aff" rid="aff77"><sup>77</sup></xref></contrib><contrib contrib-type="author"><name><surname>Seixas</surname><given-names>Noah</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shy</surname><given-names>Carl</given-names></name><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Siemiatycki</surname><given-names>Jack</given-names></name><xref ref-type="aff" rid="aff78"><sup>78</sup></xref></contrib><contrib contrib-type="author"><name><surname>Silverman</surname><given-names>Debra T.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Simonato</surname><given-names>Lorenzo</given-names></name><xref ref-type="aff" rid="aff79"><sup>79</sup></xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Allan H.</given-names></name><xref ref-type="aff" rid="aff80"><sup>80</sup></xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Martyn T.</given-names></name><xref ref-type="aff" rid="aff81"><sup>81</sup></xref></contrib><contrib contrib-type="author"><name><surname>Spinelli</surname><given-names>John J.</given-names></name><xref ref-type="aff" rid="aff82"><sup>82</sup></xref></contrib><contrib contrib-type="author"><name><surname>Spitz</surname><given-names>Margaret R.</given-names></name><xref ref-type="aff" rid="aff83"><sup>83</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stallones</surname><given-names>Lorann</given-names></name><xref ref-type="aff" rid="aff84"><sup>84</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stayner</surname><given-names>Leslie T.</given-names></name><xref ref-type="aff" rid="aff85"><sup>85</sup></xref></contrib><contrib contrib-type="author"><name><surname>Steenland</surname><given-names>Kyle</given-names></name><xref ref-type="aff" rid="aff86"><sup>86</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stenzel</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="aff87"><sup>87</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stewart</surname><given-names>Bernard W.</given-names></name><xref ref-type="aff" rid="aff88"><sup>88</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stewart</surname><given-names>Patricia A.</given-names></name><xref ref-type="aff" rid="aff89"><sup>89</sup></xref></contrib><contrib contrib-type="author"><name><surname>Symanski</surname><given-names>Elaine</given-names></name><xref ref-type="aff" rid="aff90"><sup>90</sup></xref></contrib><contrib contrib-type="author"><name><surname>Terracini</surname><given-names>Benedetto</given-names></name><xref ref-type="aff" rid="aff91"><sup>91</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tolbert</surname><given-names>Paige E.</given-names></name><xref ref-type="aff" rid="aff86"><sup>86</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vainio</surname><given-names>Harri</given-names></name><xref ref-type="aff" rid="aff92"><sup>92</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vena</surname><given-names>John</given-names></name><xref ref-type="aff" rid="aff93"><sup>93</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vermeulen</surname><given-names>Roel</given-names></name><xref ref-type="aff" rid="aff38"><sup>38</sup></xref></contrib><contrib contrib-type="author"><name><surname>Victora</surname><given-names>Cesar G.</given-names></name><xref ref-type="aff" rid="aff94"><sup>94</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ward</surname><given-names>Elizabeth M.</given-names></name><xref ref-type="aff" rid="aff95"><sup>95</sup></xref></contrib><contrib contrib-type="author"><name><surname>Weinberg</surname><given-names>Clarice R.</given-names></name><xref ref-type="aff" rid="aff96"><sup>96</sup></xref></contrib><contrib contrib-type="author"><name><surname>Weisenburger</surname><given-names>Dennis</given-names></name><xref ref-type="aff" rid="aff97"><sup>97</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wesseling</surname><given-names>Catharina</given-names></name><xref ref-type="aff" rid="aff98"><sup>98</sup></xref></contrib><contrib contrib-type="author"><name><surname>Weiderpass</surname><given-names>Elisabete</given-names></name><xref ref-type="aff" rid="aff99"><sup>99</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zahm</surname><given-names>Shelia Hoar</given-names></name><xref ref-type="aff" rid="aff100"><sup>100</sup></xref></contrib><aff id="aff1"><label>1</label><addr-line>Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Imperial College, London, United Kingdom</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany</addr-line></aff><aff id="aff5"><label>5</label><addr-line>Department of Research, Cancer Registry of Norway, Oslo, Norway</addr-line></aff><aff id="aff6"><label>6</label><addr-line>Centre for Research in Environmental Epidemiology (CREAL), IMIM (Hospital del Mar Medical Research Institute), Universitat Pompeu Fabra (UPF), and CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain</addr-line></aff><aff id="aff7"><label>7</label><addr-line>School of Public Health, The University of Sydney and Sax Institute, Sydney, New South Wales, Australia</addr-line></aff><aff id="aff8"><label>8</label><addr-line>Department of Environmental Health, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA</addr-line></aff><aff id="aff9"><label>9</label><addr-line>Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA</addr-line></aff><aff id="aff10"><label>10</label><addr-line>Department of Clinical Sciences and Community Health, University of Milan and IRCCS Foundation Ca’Granda Ospedale Maggiore Policlinico, Milan, Italy</addr-line></aff><aff id="aff11"><label>11</label><addr-line>NCI, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></aff><aff id="aff12"><label>12</label><addr-line>Division of Public Health Sciences, and Alvin J. Siteman Cancer Center, Washington University, School of Medicine, St. Louis, Missouri, USA</addr-line></aff><aff id="aff13"><label>13</label><addr-line>Division of the National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></aff><aff id="aff14"><label>14</label><addr-line>KP Cantor Environmental LLC, Silver Spring, Maryland, USA</addr-line></aff><aff id="aff15"><label>15</label><addr-line>CREAL, IMIM, and CIBERESP, Barcelona, Spain</addr-line></aff><aff id="aff16"><label>16</label><addr-line>Institute of Occupational Medicine, Edinburgh, United Kingdom</addr-line></aff><aff id="aff17"><label>17</label><addr-line>Department of Public Health, Clinical and Molecular Medicine, University of Cagliari-Monserrato, Cagliari, Italy</addr-line></aff><aff id="aff18"><label>18</label><addr-line>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom</addr-line></aff><aff id="aff19"><label>19</label><addr-line>Department of Biology and Biotechnology, “Charles Darwin” Sapienza Rome University, Rome, Italy</addr-line></aff><aff id="aff20"><label>20</label><addr-line>Occupational Cancer Research Centre, Cancer Care Ontario, Toronto, Ontario, Canada</addr-line></aff><aff id="aff21"><label>21</label><addr-line>Division of Occupational and Environmental Medicine, Duke University Medical Center, Durham, North Carolina, USA</addr-line></aff><aff id="aff22"><label>22</label><addr-line>Centre for Public Health Research, Massey University, Wellington, New Zealand</addr-line></aff><aff id="aff23"><label>23</label><addr-line>Department of Environmental Health Science, and Department of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, California, USA</addr-line></aff><aff id="aff24"><label>24</label><addr-line>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line></aff><aff id="aff25"><label>25</label><addr-line>Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, Washington, USA</addr-line></aff><aff id="aff26"><label>26</label><addr-line>European Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall, United Kingdom</addr-line></aff><aff id="aff27"><label>27</label><addr-line>Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></aff><aff id="aff28"><label>28</label><addr-line>Louisiana State University School of Public Health, New Orleans, Louisiana, USA</addr-line></aff><aff id="aff29"><label>29</label><addr-line>Department of Epidemiology, Lazio Regional Health Service, Rome, Italy</addr-line></aff><aff id="aff30"><label>30</label><addr-line>Center for Environmental Research and Sustainable Technology (UFT), Universität Bremen, Bremen, Germany</addr-line></aff><aff id="aff31"><label>31</label><addr-line>School of Public Health, Curtin University, Perth, Western Australia, Australia</addr-line></aff><aff id="aff32"><label>32</label><addr-line>Department of Environmental and Occupational Health, Ecole de Santé Publique, Universite de Montreal, Montreal, Quebec, Canada</addr-line></aff><aff id="aff33"><label>33</label><addr-line>Population-based Epidemiological Cohorts Unit, Inserm UMS 011, Villejuif, France</addr-line></aff><aff id="aff34"><label>34</label><addr-line>Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark</addr-line></aff><aff id="aff35"><label>35</label><addr-line>Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden</addr-line></aff><aff id="aff36"><label>36</label><addr-line>Danish Cancer Society Research Center, Copenhagen, Denmark</addr-line></aff><aff id="aff37"><label>37</label><addr-line>Department of Epidemiology and Biostatistics, Netherlands Cancer Institute, Amsterdam, the Netherlands</addr-line></aff><aff id="aff38"><label>38</label><addr-line>Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands</addr-line></aff><aff id="aff39"><label>39</label><addr-line>German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line></aff><aff id="aff40"><label>40</label><addr-line>Epidemiology and Biostatistics Sorbonne Paris Cite Center (CRESS), INSERM, UMR 1153, Epidemiology of Childhood and Adolescent Cancers Research Group (EPICEA), Paris Descartes University, F-75015, Paris, France</addr-line></aff><aff id="aff41"><label>41</label><addr-line>Department of Public Health Sciences, University of California, Davis, Davis, California, USA</addr-line></aff><aff id="aff42"><label>42</label><addr-line>Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA</addr-line></aff><aff id="aff43"><label>43</label><addr-line>NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></aff><aff id="aff44"><label>44</label><addr-line>Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden</addr-line></aff><aff id="aff45"><label>45</label><addr-line>College of Medicine, Seoul National University, Seoul, Korea</addr-line></aff><aff id="aff46"><label>46</label><addr-line>Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA</addr-line></aff><aff id="aff47"><label>47</label><addr-line>National Institute of Occupational Health, Oslo, Norway</addr-line></aff><aff id="aff48"><label>48</label><addr-line>CREAL, IMIM, and CIBERESP, Barcelona, Spain; National School of Public Health, Athens Greece</addr-line></aff><aff id="aff49"><label>49</label><addr-line>Department of Work Environment, University of Massachusetts Lowell, Lowell, Massachusetts, USA</addr-line></aff><aff id="aff50"><label>50</label><addr-line>Centre Francois Baclesse, Universite de Caen, Caen, France</addr-line></aff><aff id="aff51"><label>51</label><addr-line>Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA</addr-line></aff><aff id="aff52"><label>52</label><addr-line>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA</addr-line></aff><aff id="aff53"><label>53</label><addr-line>Department of Public Health, University of Copenhagen, Copenhagen, Denmark</addr-line></aff><aff id="aff54"><label>54</label><addr-line>National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia</addr-line></aff><aff id="aff55"><label>55</label><addr-line>Public Health Ontario, Toronto, Ontario, Canada</addr-line></aff><aff id="aff56"><label>56</label><addr-line>Prevention and Cancer Control, Cancer Care Ontario, and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</addr-line></aff><aff id="aff57"><label>57</label><addr-line>World Health Organization Regional Office for Europe, European Centre for Environment and Health, Bonn, Germany</addr-line></aff><aff id="aff58"><label>58</label><addr-line>Regional Mesothelioma Register, National Health Service, Local Health Authority, Padova, Italy</addr-line></aff><aff id="aff59"><label>59</label><addr-line>Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy</addr-line></aff><aff id="aff60"><label>60</label><addr-line>Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</addr-line></aff><aff id="aff61"><label>61</label><addr-line>City University of New York (CUNY) School of Public Health, New York, New York, USA</addr-line></aff><aff id="aff62"><label>62</label><addr-line>INRS-Institut Armand-Frappier, Universite du Quebec, Laval, Quebec, Canada</addr-line></aff><aff id="aff63"><label>63</label><addr-line>Department of Environmental Health Sciences, and Columbia Center for Children’s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA</addr-line></aff><aff id="aff64"><label>64</label><addr-line>Department of Environmental and Occupational Health, George Washington University Milken Institute School of Public Health, Washington, DC, USA</addr-line></aff><aff id="aff65"><label>65</label><addr-line>IMIM, CIBERESP, and School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain</addr-line></aff><aff id="aff66"><label>66</label><addr-line>Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland, and School of Health Sciences, University of Tampere, Tampere, Finland</addr-line></aff><aff id="aff67"><label>67</label><addr-line>Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA</addr-line></aff><aff id="aff68"><label>68</label><addr-line>School of Environmental Sciences, Ontario Agricultural College, University of Guelph, Guelph, Ontario, Canada</addr-line></aff><aff id="aff69"><label>69</label><addr-line>Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, Los Angeles, California, USA</addr-line></aff><aff id="aff70"><label>70</label><addr-line>Department of Pediatric Oncology, Emma Children’s Hospital/Academic Medical Center, Amsterdam, the Netherlands</addr-line></aff><aff id="aff71"><label>71</label><addr-line>MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom</addr-line></aff><aff id="aff72"><label>72</label><addr-line>Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA</addr-line></aff><aff id="aff73"><label>73</label><addr-line>Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA</addr-line></aff><aff id="aff74"><label>74</label><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</addr-line></aff><aff id="aff75"><label>75</label><addr-line>Epidemiology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></aff><aff id="aff76"><label>76</label><addr-line>Cancer Epidemiology Research Programme, Unit of Infections and Cancer, Bellvitge Biomedical Research Institute (IDIBELL), CIBERESP Catalan Institute of Oncology, Barcelona, Spain</addr-line></aff><aff id="aff77"><label>77</label><addr-line>Cancer Prevention and Research Institute (ISPO), Florence, Italy</addr-line></aff><aff id="aff78"><label>78</label><addr-line>Department of Social and Preventive Medicine, Ecole de Santé Publique, Universite de Montreal, Montreal, Quebec, Canada</addr-line></aff><aff id="aff79"><label>79</label><addr-line>Laboratory of Public Health and Population Studies, Department of Molecular Medicine, University of Padova, Padova, Italy</addr-line></aff><aff id="aff80"><label>80</label><addr-line>The School of Public Health, University of California, Berkeley, Berkeley, California, USA</addr-line></aff><aff id="aff81"><label>81</label><addr-line>Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California, USA</addr-line></aff><aff id="aff82"><label>82</label><addr-line>Cancer Control Research, BC Cancer Agency and School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></aff><aff id="aff83"><label>83</label><addr-line>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA</addr-line></aff><aff id="aff84"><label>84</label><addr-line>Department of Psychology, Colorado State University, Fort Collins, Colorado, USA</addr-line></aff><aff id="aff85"><label>85</label><addr-line>Division of Epidemiology and Biostatistics, University of Illinois at Chicago, School of Public Health, Chicago, Illinois, USA</addr-line></aff><aff id="aff86"><label>86</label><addr-line>Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA</addr-line></aff><aff id="aff87"><label>87</label><addr-line>Exposure Assessment Applications LLC, Arlington, Virginia, USA</addr-line></aff><aff id="aff88"><label>88</label><addr-line>Cancer Control Program, South East Sydney Public Health Unit, Randwick, New South Wales, Australia</addr-line></aff><aff id="aff89"><label>89</label><addr-line>Stewart Exposure Assessments LLC, Arlington, Virginia, USA</addr-line></aff><aff id="aff90"><label>90</label><addr-line>Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA</addr-line></aff><aff id="aff91"><label>91</label><addr-line>University of Torino and Centro di Riferimento per l’Epidemiologia e la Prevenzione Oncologica, CPO Piemonte, Torino, Italy</addr-line></aff><aff id="aff92"><label>92</label><addr-line>Finnish Institute of Occupational Health, Helsinki, Finland</addr-line></aff><aff id="aff93"><label>93</label><addr-line>Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA</addr-line></aff><aff id="aff94"><label>94</label><addr-line>Universdade Federal de Pelotas, Rio Grande do Sul, Brazil</addr-line></aff><aff id="aff95"><label>95</label><addr-line>American Cancer Society Inc., Atlanta, Georgia, USA</addr-line></aff><aff id="aff96"><label>96</label><addr-line>Biostatistics and Computational Biology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></aff><aff id="aff97"><label>97</label><addr-line>Department of Pathology, City of Hope National Medical Center, Duarte, California, USA</addr-line></aff><aff id="aff98"><label>98</label><addr-line>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</addr-line></aff><aff id="aff99"><label>99</label><addr-line>Department of Community Medicine, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway; Cancer Registry of Norway, Oslo, Norway; Genetic Epidemiology Group, Folkhalsan Research Center, Helsinki, Finland; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></aff><aff id="aff100"><label>100</label><addr-line>Shelia Zahm Consulting, Hermon, Maine, USA</addr-line></aff><aff id="aff101"><label>*</label>Deceased</aff></contrib-group><author-notes><corresp id="cor1">Address correspondence to N. Pearce, Department of Medical Statistics, London School of Hygiene and Tropical Medicine, Keppel St., London WC1E 7HT, United Kingdom. Telephone: 44-20-7958-8151. E-mail: <email>neil.pearce@lshtm.ac.uk</email></corresp></author-notes><pub-date pub-type="epub"><day>24</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2015</year></pub-date><volume>123</volume><issue>6</issue><fpage>507</fpage><lpage>514</lpage><history><date date-type="received"><day>14</day><month>9</month><year>2014</year></date><date date-type="accepted"><day>20</day><month>2</month><year>2015</year></date><date><day>24</day><month>2</month><year>2015</year></date><date><day>01</day><month>6</month><year>2015</year></date></history><permissions><license xlink:href="http://creativecommons.org/publicdomain/mark/1.0/" license-type="public-domain"><license-p>Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. </license-p></license></permissions><abstract><p>Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used to perform these evaluations. Some critics have claimed that failures of IARC Working Groups to recognize study weaknesses and biases of Working Group members have led to inappropriate classification of a number of agents as carcinogenic to humans.</p><p>Objectives: The authors of this Commentary are scientists from various disciplines relevant to the identification and hazard evaluation of human carcinogens. We examined criticisms of the IARC classification process to determine the validity of these concerns. Here, we present the results of that examination, review the history of IARC evaluations, and describe how the IARC evaluations are performed.</p><p>Discussion: We concluded that these recent criticisms are unconvincing. The procedures employed by IARC to assemble Working Groups of scientists from the various disciplines and the techniques followed to review the literature and perform hazard assessment of various agents provide a balanced evaluation and an appropriate indication of the weight of the evidence. Some disagreement by individual scientists to some evaluations is not evidence of process failure. The review process has been modified over time and will undoubtedly be altered in the future to improve the process. Any process can in theory be improved, and we would support continued review and improvement of the IARC processes. This does not mean, however, that the current procedures are flawed.</p><p>Conclusions: The IARC Monographs have made, and continue to make, major contributions to the scientific underpinning for societal actions to improve the public’s health.</p><p>Citation: Pearce N, Blair A, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli AA, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, ‘t Mannetje A, McMichael AJ, McLaughlin JR, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer FE, Monson R, Nordby KC, Olshan AF, Parent ME, Perera FP, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Seniori Costantini A, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L, Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart PA, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger D, Wesseling C, Weiderpass E, Zahm SH. 2015. IARC Monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect 123:507–514; <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1289/ehp.1409149">http://dx.doi.org/10.1289/ehp.1409149</ext-link></p></abstract></article-meta></front><body><sec sec-type="intro"><title>Introduction</title><p>Important advances in human health have come from the recognition of health hazards and the development of policy actions to address them (<xref rid="r6" ref-type="bibr">Brownson et al. 2009</xref>; <xref rid="r11" ref-type="bibr">Espina et al. 2013</xref>; <xref rid="r34" ref-type="bibr">Samet 2000</xref>). Government and nongovernmental organizations use expert panels to review the scientific literature and to assess its relevance to public health policies. Scientific experts are charged with reviewing the quality and quantity of the scientific evidence and providing scientific interpretations of the evidence that underpin a range of health policy decisions.</p><p>The <italic>IARC Monographs on the Evaluation of Carcinogenic Risks to Humans</italic> of the International Agency for Research on Cancer (IARC) are a prominent example of such an expert review process. The goal of the Monograph Programme is to assess carcinogenic hazards from occupational, environmental, and lifestyle exposures and agents, thus providing an essential step in the societal decision-making process to identify and then control carcinogenic hazards. For these evaluations, IARC assembles groups of scientists with a range of relevant scientific expertise (called “Working Groups”) to review and assess the quality and strength of evidence from informative publications and perform a hazard evaluation to assess the likelihood that the agents of concern pose a cancer hazard to humans (<xref rid="r39" ref-type="bibr">Tomatis 1976</xref>). IARC has used this approach for four decades, since the first Monograph in 1972 (<xref rid="r17" ref-type="bibr">IARC 1972</xref>). Although widely accepted internationally, there have been criticisms of the classification of particular agents in the past, and more recent criticisms have been directed at the general approach adopted by IARC for such evaluations (<xref rid="r4" ref-type="bibr">Boffetta et al. 2009</xref>; <xref rid="r9" ref-type="bibr">Epidemiology Monitor 2012</xref>; <xref rid="r22" ref-type="bibr">Ioannidis 2005</xref>; <xref rid="r24" ref-type="bibr">Kabat 2012</xref>; <xref rid="r28" ref-type="bibr">McLaughlin et al. 2010</xref>, <xref rid="r27" ref-type="bibr">2011</xref>).</p><p>The Monographs are widely used and referenced by governments, organizations, and the public around the world; therefore, it is critical that Working Group conclusions be clear and transparent. In addition to the actual evaluation, a major contribution of the Monographs is the assembly of relevant literature and its dissemination to the public. We recognize that no system of evaluation is perfect. It is important to foster continuing improvement of the methods used by IARC and other bodies that review scientific evidence. The IARC process itself has been modified from time to time (e.g., addition of specific evaluation of mechanistic data and greater use of formal meta-analyses and data-pooling approaches). Indeed, as recently as April 2014, the IARC Monographs program has been a subject of a review by the Advisory Group to recommend priorities for IARC Monographs during 2015–2019 (<xref rid="r36" ref-type="bibr">Straif et al. 2014</xref>). The Advisory Group has made a number of recommendations on further improvements in the Monographs process specifically related to conflict of interest, transparency, and the use of the systematic review procedures in data gathering and evaluation. Thus, possible changes to the process are periodically considered by IARC governing groups (Scientific Council and Governing Council) and Advisory Groups.</p><p>Here, we focus on current IARC processes and practices because these have been the focus of recent criticisms. The authors of this Commentary are scientists from a wide range of disciplines who are involved in designing and conducting studies that provide data used in hazard evaluations, such as those performed by IARC. Many (but not all) of us have served on IARC Monograph Working Groups, but none are current IARC staff. We first discuss the history of IARC, and describe how the IARC evaluations are performed in order to foster evidence-based policy. We then describe why unbiased evaluations, based on the evidence and free of conflicts of interest, are necessary for public health decision making. Finally, we discuss the recent criticisms of the IARC approach.</p></sec><sec><title>The IARC Monographs</title><p><italic>History of the IARC Monographs.</italic> Shortly after IARC’s establishment, its parent entity, the World Health Organization (WHO), asked IARC to prepare a list of agents known to cause cancer in humans. IARC recognized the need for a systematic process to determine which agents should be listed. Such a process was launched in 1972 by Lorenzo Tomatis, then Chief of the Division of Carcinogenicity of IARC (<xref rid="r39" ref-type="bibr">Tomatis 1976</xref>). IARC is funded by the governments of 24 countries that have decided to become members, in addition to competitive grants from funding agencies. The IARC Monograph Programme is mainly funded by the U.S. National Cancer Institute through a renewable grant subject to peer review of the program. Other sources of external funding have included the European Commission Directorate-General of Employment, Social Affairs and Equal Opportunities; the U.S. National Institute of Environmental Health Sciences; and the U.S. Environmental Protection Agency.</p><p>The IARC process antedates current systematic review methods, but anticipated some of them, for example, with regard to transparent literature identification. In the IARC process, agents are assessed for carcinogenic hazard and assigned to one of five categories, ranging from carcinogenic to humans to probably not carcinogenic to humans (Appendix 1). The classification categories are described in the preamble to the Monographs (<xref rid="r18" ref-type="bibr">IARC 2006</xref>). Carcinogenic hazard identification refers to an assessment of whether an agent causes cancer. Hazard identification does not predict the magnitude of cancer risks under specific conditions; this can be determined only with appropriate exposure–response information (<xref rid="r32" ref-type="bibr">National Research Council 2009</xref>).</p><p><italic>The IARC Monograph process</italic>. The process for the preparation of an IARC Monograph is clearly described in the Preamble, which is published as part of each Monograph (e.g., <xref rid="r19" ref-type="bibr">IARC 2014a</xref>). It starts with the nomination of candidate agents. Nominations come from national regulatory agencies, scientists, and stakeholders, including public health professionals, experts in environmental or occupational hygiene, industry representatives, and private citizens. It is important to note that anyone (including private citizens) can participate in the nomination process. The Monograph Programme convenes meetings of special Advisory Groups (composed of external scientists that possess a broad range of relevant professional skills) to review agents nominated for evaluation and to suggest IARC priorities for such reviews (<xref rid="r41" ref-type="bibr">Ward et al. 2010</xref>). Announcements of a review are made on the IARC website (<ext-link ext-link-type="uri" xlink:href="http://monographs.iarc.fr/ENG/Meetings/">http://monographs.iarc.fr/ENG/Meetings/</ext-link>). For example, in 2013 IARC sought nominations for agents to be evaluated in 2015–2019 (<xref rid="r20" ref-type="bibr">IARC 2014b</xref>). An Advisory Group reviewed the nominated agents and exposures, added several new ones, and discussed the priorities for each.</p><p>The IARC staff makes the final selection of agents for review by taking into account the prevalence and intensity of exposure (of both occupational groups and the general population) and availability of sufficient literature for an evaluation of carcinogenicity, as well as advice from the Advisory Groups. The large majority of evaluations concern specific compounds, but there are also monographs on various occupations or industries, for example, aluminum production, insecticide applicators, firefighters, manufacture of leather goods, leather tanning and processing, welding, painters, petroleum refining, and pulp and paper manufacturing. Some individual exposures that occur in these settings have also been evaluated.</p><p>The next step is the selection of members of the Working Group (WG). IARC staff review the literature to identify Working Group candidates and specialists in relevant areas of expertise; they also seek names of possible candidates from the scientific community and advisory groups. The list of potential members, including disclosure of relevant conflicts of interest, is posted on the IARC website (<ext-link ext-link-type="uri" xlink:href="http://monographs.iarc.fr/ENG/Meetings/">http://monographs.iarc.fr/ENG/Meetings/</ext-link>) before the WG is convened, and anyone can send comments. Members are typically scientists who have conducted research relevant to the agent under review, but not necessarily on the specific agent. Selection procedures are evaluated yearly by the Scientific and the Governing Councils. The IARC Section of Monographs also has an external Advisory Board, made up of independent scientists, that periodically peer reviews its activities. In addition to Working Group members, invited specialists, representatives of health agencies, stakeholder observers, and the IARC Secretariat also attend meetings.</p><p>The responsibility of the Working Group is to review the literature before the Monograph meeting, discuss the literature at the meeting, and then classify whether an agent is carcinogenic, probably carcinogenic, possibly carcinogenic, not classifiable, or probably not carcinogenic to humans (see Appendix 1). Working Group members are also responsible for writing the IARC Monograph, which must both review the literature and explain why the Working Group came to their specific conclusions.</p><p>The procedures used to evaluate the scientific evidence are described in the Preamble to the Monographs (<xref rid="r18" ref-type="bibr">IARC 2006</xref>). It is important to stress that only Working Group members conduct the actual evaluation (<xref rid="r42" ref-type="bibr">Wild and Cogliano 2011</xref>; <xref rid="r43" ref-type="bibr">Wild and Straif 2011</xref>). IARC staff facilitate the evaluation process and ensure that the procedures described in the Preamble are followed; however, they do not determine the outcomes.</p><p>IARC assessments of carcinogenicity are based on, and necessarily limited to, scientific evidence available at the time of the review. The evidence comes from epidemiologic studies, animal bioassays, pharmacokinetic/mechanistic experiments, and surveys of human exposure. The aim is to include all relevant papers on cancer in humans and experimental animals that have been published, or accepted for publication, in peer-reviewed scientific journals and also any publicly available government or agency documents that provide data on the circumstances and extent of human exposure. To that end, the search of the literature takes a comprehensive approach. Papers that are found not to provide useful evidence can be excluded later in the process. IARC staff first use previous IARC Monographs (if available), database searches using relevant text strings, and contact with investigators in the field to identify potentially relevant material. Thus, the initial assembly of the literature is performed by individuals who are not engaged in the actual evaluation. Working Group members are then assigned various writing tasks and are instructed to perform their own literature searches to identify any further papers that might have been missed. In addition, all of the papers assembled by IARC are made available to the full Working Group before they meet, and any member can recommend other papers not previously identified that they think should be considered. Finally, papers can be recommended by stakeholder representatives before or during the Working Group meeting.</p><p>At the meeting of the Working Group, the assembled documents are reviewed and summarized by discipline-related subgroups.However, any member of the Working Group has access to all of the assembled literature. The summaries are distributed to all subgroups, and information from all disciplines is discussed in plenary sessions prior to assigning the agents to a specific carcinogenicity category.</p><p>Because new findings continually emerge in the literature, agents are reconsidered when IARC and IARC Advisory Groups judge that there is sufficient additional information that might alter a previous evaluation. Thus, conclusions regarding human carcinogenicity of particular substances may change as new evidence becomes available. For some agents, this reevaluation has resulted in progression toward greater certainty regarding their human carcinogenicity, whereas for others the progress has been moved toward less certainty. Such movements are expected in an open, transparent, and evidence-based process. A comprehensive update of all Group 1 carcinogens was recently accomplished in Volume 100 A through F (<ext-link ext-link-type="uri" xlink:href="http://monographs.iarc.fr/ENG/Monographs/PDFs/index.php">http://monographs.iarc.fr/ENG/Monographs/PDFs/index.php</ext-link>).</p><p>Usually, several agents are evaluated in a single meeting lasting more than 1 week. After discussing the evidence fully, the Working Group members follow the published IARC procedures for combining information from epidemiologic studies and bioassays to arrive at a preliminary classification (<xref rid="r19" ref-type="bibr">IARC 2014a</xref>). Mechanistic data are then considered in order to determine whether they warrant a change from the preliminary classification. The Working Group then votes on the final determination. Many votes are unanimous, but on occasion some reviewers may favor a higher or lower ranking than the majority. When there is dissent, alternative interpretations and their underlying reasoning are sometimes reported in the rationale for the evaluation if the dissenters feel their point of view is not sufficiently addressed in the monograph.</p><p><italic>Consideration of the totality of the evidence</italic>. IARC Working Groups make every effort to provide full and transparent documentation of what evidence was assembled, how it was evaluated, and which papers were most important for the hazard evaluation. Consequently, the monographs are often quite lengthy, containing many evidence tables [see, for example, the recent monograph on trichloroethylene (<xref rid="r21" ref-type="bibr">IARC 2014c</xref>)]. Evaluations involve consideration of all of the known relevant evidence from epidemiologic, animal, pharmacokinetic/mechanistic, and exposure studies to assess cancer hazard in humans. Information on human exposure is not formally graded as part of the overall assessment of carcinogenic hazard; however, these data make a critical contribution to the process by characterizing the timing, duration, and levels of exposure in the population, and in evaluating the quality of the exposure assessment in epidemiologic studies.</p><p>Doubts and criticisms have sometimes been expressed about the relative weights attributed to evidence from individual disciplines to the assessment of cancer hazards to humans; however, each discipline provides important evidence toward the overall evaluation of causality according to the Bradford Hill considerations (<xref rid="r16" ref-type="bibr">Hill 1965</xref>). Because the totality of the evidence is considered, deficiencies in one discipline are often offset by strengths in another. For example, epidemiologic studies may focus on population-relevant exposures, whereas findings from animal experiments usually involve higher exposures but are less susceptible to confounding.</p><p>Long-term animal bioassays and mechanistic studies provide critical information on the capacity of an agent to produce cancer in mammalian systems, including humans, and to contribute to decisions that would lead to better protection of human health. Bioassays are the backbone of regulatory science because they provide the opportunity to rigorously evaluate potential hazards before there is widespread human exposure. Bioassays and mechanistic studies are sometimes criticized for employing exposure routes and doses that in most instances humans would not experience, although experimental dose categories sometimes approach exposure levels found in occupational situations. There is evidence that carcinogenicity in human and animal studies is often concordant, although data may differ as to the affected cancer site (<xref rid="r15" ref-type="bibr">Haseman 2000</xref>; <xref rid="r26" ref-type="bibr">Maronpot et al. 2004</xref>; <xref rid="r40" ref-type="bibr">Tomatis 2002</xref>). A major effort to evaluate the concordance between animal and human results is currently under way; two Working Groups were convened at IARC in 2012, and a systematic evaluation of the correspondence between human and animal data was undertaken (a report is not yet publicly available).</p></sec><sec><title>Criticisms of the IARC Process</title><p>IARC Monographs are widely used to identify potential carcinogenic hazards to humans and serve as reference documents summarizing the literature on many different agents. In recent years, however, individuals have criticized both the classification of individual agents as well as the general evaluative approach (<xref rid="r4" ref-type="bibr">Boffetta et al. 2009</xref>; <xref rid="r9" ref-type="bibr">Epidemiology Monitor 2012</xref>; <xref rid="r24" ref-type="bibr">Kabat 2012</xref>; <xref rid="r28" ref-type="bibr">McLaughlin et al. 2010</xref>, <xref rid="r27" ref-type="bibr">2011</xref>). We discuss four of these criticisms below.</p><p><italic>Criticisms of epidemiology</italic>. Some of the criticisms of the IARC process have occurred in the context of more general criticisms of epidemiology as a science (<xref rid="r23" ref-type="bibr">Kabat 2008</xref>); these were discussed in detail by <xref rid="r2" ref-type="bibr">Blair et al. (2009)</xref>. Potential methodological weaknesses for observational epidemiologic studies are well recognized and can be found in any epidemiologic textbook (<xref rid="r7" ref-type="bibr">Checkoway et al. 2004</xref>; <xref rid="r33" ref-type="bibr">Rothman et al. 2008</xref>). Most studies are subject to one or more methodological limitations, but this does not necessarily invalidate their findings (<xref rid="r2" ref-type="bibr">Blair et al. 2009</xref>). In fact, the value of epidemiologic studies has been shown by the identification of a number of well-established human carcinogens, including tobacco, asbestos, benzene, hexavalent chromium, and some viruses, in multiple studies. Some critics also argue that small or nonexistent health risks are unjustifiably highlighted and hyped by researchers who have a vested interest in continued research funding and the need to publish to benefit their careers (<xref rid="r3" ref-type="bibr">Boffetta et al. 2008</xref>; <xref rid="r23" ref-type="bibr">Kabat 2008</xref>; <xref rid="r28" ref-type="bibr">McLaughlin et al. 2010</xref>, <xref rid="r27" ref-type="bibr">2011</xref>; <xref rid="r38" ref-type="bibr">Taubes 1995</xref>). However, such overstated results are unlikely to exert much of an influence in a Monograph because IARC evaluations are based on the totality of the evidence. The problem would have to occur in multiple studies, and the Working Group would have to be unable to identify it or be unwilling to weigh such studies appropriately. Incorrect positive conclusions regarding carcinogenicity may also occur in reviews of multiple studies because of publication bias, which may selectively populate the literature only with “positive” findings. However, once a topic is recognized as scientifically important, reports on relevant studies will be published regardless of the findings, so publication bias is mainly a concern for newly arising issues. To evaluate the potential for publication bias, Working Groups consider whether stronger negative studies (both in terms of design and sample size) have emerged after publication of an initial cluster of smaller and/or weaker positive studies. Funnel plots help in the assessment of bias relating to sample size and publication bias (<xref rid="r5" ref-type="bibr">Borenstein et al. 2009</xref>). In contrast, there are no established statistical techniques to clearly characterize strength of design.</p><p>One of the distinctive features of epidemiology is that criticism and self-criticism are firmly embedded in the discipline. A great deal of work has been done on developing methods for critical appraisal (<xref rid="r8" ref-type="bibr">Elwood 2007</xref>) and for assessing the likely strength and direction of possible biases (<xref rid="r33" ref-type="bibr">Rothman et al. 2008</xref>). Epidemiologists and other members on Working Groups routinely use various approaches to assess possible bias in study design and analysis when weighing the strengths of different studies.</p><p><italic>The issue of false positives</italic>. Epidemiology specifically has been criticized for a tendency to produce false-positive results (i.e., individual study associations not borne out by the weight of the evidence) or to preferentially report positive findings over negative or inconclusive findings (i.e., publication bias) (<xref rid="r3" ref-type="bibr">Boffetta et al. 2008</xref>, <xref rid="r4" ref-type="bibr">2009</xref>; <xref rid="r22" ref-type="bibr">Ioannidis 2005</xref>; <xref rid="r24" ref-type="bibr">Kabat 2012</xref>; <xref rid="r29" ref-type="bibr">McLaughlin and Tarone 2013</xref>). This criticism has been most often applied to potential false positives from individual studies, but it has been inferred that this problem may also apply to overall hazard evaluations, which use findings from multiple studies. We will consider each of these issues in turn.</p><p>False-positive findings may occur by chance, particularly when many combinations of exposures and health outcomes have been examined in a single study without strong prior expectations of association; this happens often, for example, in genome-wide association studies where thousands of gene–disease associations are evaluated. Chance, of course, operates in all disciplines and in both observational and experimental studies. However, there are well-known statistical techniques to reduce the probability of declaring chance findings as “positive” (<xref rid="r33" ref-type="bibr">Rothman et al. 2008</xref>). Independent replication, however, is the most convincing way of checking for “chance” findings; hazard evaluations, such as those conducted by IARC Working Groups, rely heavily on reproducibility in independent studies and also interpret data following Bradford Hill principles (<xref rid="r16" ref-type="bibr">Hill 1965</xref>).</p><p>False negatives are more difficult to address, and perhaps they occur more frequently than false positives because of low statistical power, nondifferential misclassification of exposure and/or outcome, and incomplete follow-up, which tends to reduce the observed difference in risk between the exposed and nonexposed populations (<xref rid="r1" ref-type="bibr">Ahlbom et al. 1990</xref>; <xref rid="r2" ref-type="bibr">Blair et al. 2009</xref>; <xref rid="r14" ref-type="bibr">Grandjean 2005</xref>; <xref rid="r33" ref-type="bibr">Rothman et al. 2008</xref>). A new positive association stimulates research, whereas studies finding no associations tend to stifle further work.</p><p>There are difficulties in conducting epidemiologic studies of agents that are relatively “weak” carcinogens, or for stronger carcinogens where exposure is very low because bias and confounding can obscure weak positive associations (<xref rid="r25" ref-type="bibr">MacMahon et al. 1981</xref>). In general, weak carcinogens and low levels of exposure result in a smaller “signal-to-noise” ratio making the real signal more difficult to detect. Although the identification of small relative risks to humans poses special challenges to scientific research, the refinement of study designs, improvements in methods of exposure assessment, and the use of biomarkers have helped to address the problems (e.g., newer studies on the effects of air pollution, the growth in opportunities to examine gene–environment interactions) (<xref rid="r13" ref-type="bibr">Gallo et al. 2011</xref>). In some situations, there is less of a problem. For example, in occupational studies, exposures and relative risks may be higher while differences in lifestyle factors between different groups of workers are smaller (<xref rid="r7" ref-type="bibr">Checkoway et al. 2004</xref>); thus, any confounding by nonoccupational factors is likely to be weak, even from potent causes of cancer such as cigarette smoking (<xref rid="r35" ref-type="bibr">Siemiatycki et al. 1988</xref>). Of course, the interpretation of such studies is enhanced when there is supporting evidence from bioassays and/or mechanistic studies.</p><p>False-positive and false-negative findings in individual studies may arise by chance or bias, including bias due to confounding (<xref rid="r33" ref-type="bibr">Rothman et al. 2008</xref>). However, the evaluation of multiple independent epidemiologic studies from various geographic locations, involving a variety of study designs, as well as evidence from experimental studies, reduces the possibility that false-positive findings from any individual study influences the overall evaluation process. Some studies may have greater influence than others because of methodological strengths and/or large sample size. The use of information from a variety of study designs reduces the likelihood of false-positive evaluations because it is unlikely that the same biases will occur in multiple studies based on different populations under different study designs. Moreover, apparently conflicting results from epidemiologic studies do not necessarily indicate that some are false positive or false negative. This might, for example, reflect differences in levels of exposure or susceptibility to the effects of exposure (effect modification). Finally, judgment by the Working Group is not based exclusively on epidemiologic studies but usually also on results from laboratory and mechanistic studies that provide further evidence and biological coherence. For the Monographs that evaluate carcinogenic hazards associated with specific occupations or industries, the exposures of interest usually involve a complex mixture of chemicals. For these evaluations, most information comes from epidemiologic studies, although exposures to individual agents occurring at these workplaces may have been evaluated in experimental studies.</p><p><italic>Discontent with IARC Monograph processes</italic>. The IARC Monograph evaluation process has been criticized and it has been alleged that “a number of scientists with direct experience of IARC have felt compelled to dissociate themselves from the agency’s approach to evaluating carcinogenic hazards” (<xref rid="r24" ref-type="bibr">Kabat 2012</xref>). This is a serious charge. However, the author of this claim provided no evidence to support the charge that a “number of scientists” have dissociated themselves from the process, nor has there been any indication of how many scientists have taken this step, or for what reason. In science, we expect sweeping statements such as this to be appropriately documented. We have not been able to identify any credible support for this contention.</p><p>There is an IARC Governing Council and a Scientific Council to provide oversight and guidance to the agency. The Governing Council represents the participating states and sets general IARC policy. It appoints the IARC Director and members of the Scientific Council. The latter are independent scientists who are selected to provide scientific expertise and not as representatives of the member states. They serve for 4 years and serve without pay. The voting members of Monograph Working Groups are not employed by IARC, and they perform this task without financial compensation. There have been 111 volumes, including six separate documents under Volume 100, and three Supplements. Over the years, as the number of publications for each agent to be evaluated increased, the size of Working Groups has increased. Early in the process they were sometimes as small as 10, but now they sometimes include as many as 30 scientists. We estimate that over the entire Monograph series, approximately 1,500 scientists have served as Working Group members, and of course many scientists have also served on the Advisory Groups, Scientific Council, and Governing Council. Thus, if even a small percentage of these scientists were disenchanted with the IARC process, it would result in a considerable number of such individuals and should be easy to document. To be taken seriously, the “dissociation” criticism needs to be supported by documented information describing the number of scientists who have taken this action.</p><p><italic>Criticisms of specific evaluations</italic>. Some criticisms of the IARC process relate to specific agents, where it is asserted that the hazard evaluations of category 2B, 2A, or 1 are not supported by the scientific literature. In the 111 volumes of the Monographs produced over the four decades since 1971, 970 agents have been considered, 114 (12%) have been classified as carcinogenic to humans (Group 1), 69 (7%) as probably carcinogenic (Group 2A), 283 (29%) as possibly carcinogenic (Group 2B), 504 (52%) as not classifiable regarding their carcinogenicity (Group 3), and 1 (< 1%) as probably not carcinogenic to humans (Group 4). Thus, even for this highly select group of agents (i.e., those selected for evaluation because there was some concern that they might be carcinogenic), more than one-half were “not classifiable” or “probably not carcinogenic,” and a further 29% were placed into the category of possibly carcinogenic to humans. This distribution, based on nearly 1,000 evaluations in which fewer than one in five agents were classified as carcinogenic or probably carcinogenic to humans, does not support a conclusion that the process is heavily biased toward classifying agents as carcinogenic (<xref rid="r4" ref-type="bibr">Boffetta et al. 2009</xref>; <xref rid="r24" ref-type="bibr">Kabat 2012</xref>).</p><p>The monographs for formaldehyde, coffee, DDT, and radiofrequency electromagnetic radiation have been cited as examples of problematic evaluations by some (<xref rid="r24" ref-type="bibr">Kabat 2012</xref>) [among these, only formaldehyde was classified as known to be carcinogenic to humans (Group 1) by an IARC Working Group]. These are important agents. However, to accept the charge that IARC evaluations are fundamentally biased, one has to assume that the scientists who were members of the Working Groups were incapable of appropriately evaluating weaknesses in the data, or that they distorted the evaluative process because of personal biases. In our experience, neither of these assertions is correct. Dissent among scientists is not unusual in any area of science. It is a strength of the scientific process. The IARC process capitalizes on this by bringing scientists from different disciplines together in one room to evaluate the literature and to reach a reasoned conclusion. Differences of opinion occur among Working Group members. These differences, however, typically involve disputes related to assignment to adjacent classification categories. It is instructive that there are no instances in which a carcinogen classified at the Group 1 level by one Working Group has been reversed by another. The recent review of all Group 1 agents for Volume 100 provided ample opportunity to reverse such previous classifications, but none occurred. Every scientist could probably name a substance that has been reviewed by IARC that they might personally place in a different category from that assigned by the Working Group, but this is one opinion against the collective wisdom and process of the Working Group.</p><p><italic>Criticisms of the composition of the working groups</italic>. The composition of the Working Groups has also been criticized (<xref rid="r10" ref-type="bibr">Erren 2011</xref>; <xref rid="r28" ref-type="bibr">McLaughlin et al. 2010</xref>, <xref rid="r27" ref-type="bibr">2011</xref>); it has been argued that members of the Working Groups who have conducted research on the agents under evaluation have a vested interest in advancing their own research results in the deliberations. This criticism has been addressed directly by Wild and colleagues (<xref rid="r42" ref-type="bibr">Wild and Cogliano 2011</xref>; <xref rid="r43" ref-type="bibr">Wild and Straif 2011</xref>) from IARC, and we know of no evidence to support this contention. Even if some scientists on the Working Group have performed research on some of the agents being considered, they make up a minority of the Working Group because several agents are usually evaluated in a single meeting, so the number of Working Group members who have conducted research on any one agent is typically small. Our experience has been that having some scientists who are knowledgeable about the studies of the agent under evaluation (and can therefore answer technical queries) and others from different, but related, fields provides a knowledgeable and balanced mix of scientific backgrounds for a thoughtful evaluation of the literature.</p><p>Working Group members do not receive any fee for their work, but they are paid travel expenses, and there is some prestige associated with service on an IARC Monograph. However, most scientists asked to serve on IARC Working Groups have already achieved some measure of scientific stature, and there is no reason why this should bias their evaluation in one direction or the other. In addition, IARC strictly requires that any conflict of interests be divulged, and does not allow those with conflicts of interest to serve on Working Groups, although nonvoting observers who may have conflicts of interest are able to attend the Working Group meetings.</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>For more than four decades the IARC Monograph Programme has provided evaluations of cancer hazards to humans from many different exposures and agents. These are often the first evaluations of new and emerging threats to public health and, consequently, are subject to intense scrutiny. Although these evaluations are widely respected and used by many organizations, institutions, companies, and government agencies to improve the public’s health, IARC has recently been subject to criticism over conclusions on specific agents, the process that leads to such conclusions, and membership of the Working Groups. Debate and criticism facilitate self-correction and a check on the validity in science. We are concerned, however, that the criticisms expressed by a vocal minority regarding the evaluations of a few agents may promote the denigration of a process that has served the public and public health well for many decades for reasons that are not supported by data.</p><p>There has been very broad involvement of the scientific community in the IARC Monograph Programme through participation in the Working Groups and service on the IARC Governing and Scientific Councils and ad hoc Advisory Board for the Monograph Programme. The long list of scientists who are coauthors of this paper attests to the strong support that IARC has in the scientific community. Many exposures that IARC has evaluated have also been independently evaluated by other institutions, such as the U.S. National Toxicology Program (<ext-link ext-link-type="uri" xlink:href="https://ntp.niehs.nih.gov/">https://ntp.niehs.nih.gov/</ext-link>); U.S. Environmental Protection Agency (<ext-link ext-link-type="uri" xlink:href="http://www.epa.gov/">http://www.epa.gov/</ext-link>); National Academy of Sciences (<ext-link ext-link-type="uri" xlink:href="http://www.nasonline.org/">http://www.nasonline.org/</ext-link>); the American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Values and Biological Exposure Indices (<ext-link ext-link-type="uri" xlink:href="http://www.acgih.org/">http://www.acgih.org/</ext-link>); the Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals (<ext-link ext-link-type="uri" xlink:href="http://www.av.se/arkiv/neg/">http://www.av.se/arkiv/neg/</ext-link>); Institute of Occupational Medicine (<ext-link ext-link-type="uri" xlink:href="http://www.iom-world.org/">http://www.iom-world.org/</ext-link>); World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Expert Reports; European Chemicals Agency (<ext-link ext-link-type="uri" xlink:href="https://echa.europa.eu">https://echa.europa.eu</ext-link>); <xref rid="r37" ref-type="bibr">Swedish Criteria Group for Occupational Standards (2013)</xref>; California Office of Environmental Hazard Assessment (Proposition 65; <ext-link ext-link-type="uri" xlink:href="http://oehha.ca.gov/prop65/background/p65plain.html">http://oehha.ca.gov/prop65/background/p65plain.html</ext-link>); Health Canada Bureau of Chemical Safety (<ext-link ext-link-type="uri" xlink:href="http://www.hc-sc.gc.ca/ahc-asc/branch-dirgen/hpfb-dgpsa/fd-da/bcs-bsc/index-eng.php">http://www.hc-sc.gc.ca/ahc-asc/branch-dirgen/hpfb-dgpsa/fd-da/bcs-bsc/index-eng.php</ext-link>); Scientific Committee on Occupational Exposure Limits (SCOEL), European Commission, Employment, Social Affairs and Inclusion (<ext-link ext-link-type="uri" xlink:href="http://ec.europa.eu/social/main.jsp?catId=148&langId=en&intPageId=684">http://ec.europa.eu/social/main.jsp?catId=148&langId=en&intPageId=684</ext-link>); European Food Safety Authority (<xref rid="r12" ref-type="bibr">EFSA 2013</xref>); and European Chemicals Agency (ECHA; <ext-link ext-link-type="uri" xlink:href="http://echa.europa.eu/">http://echa.europa.eu/</ext-link>). Assessments from these groups typically come to conclusions similar to those from IARC. This further indicates broad agreement within the scientific community regarding evidence on carcinogenicity in the scientific literature and expands the number of scientists who do not have a “vested interest” but who have generally agreed with those conclusions.</p><p>Disagreement with the conclusions in an IARC Monograph for an individual agent is not evidence for a failed or biased approach. Some disagreement about the carcinogenic hazard of important agents seems inherent to the scientific enterprise and is unavoidable at early stages of the hazard evaluation, where IARC usually operates. Because the evaluations are not—and should not be—static, it is difficult to see how such assessments could be addressed any differently. Substances now universally recognized as human carcinogens (e.g., tobacco, asbestos) at one time went through a quite lengthy period of contentious debate (<xref rid="r30" ref-type="bibr">Michaels 2006</xref>, <xref rid="r31" ref-type="bibr">2008</xref>). Any process can in theory be improved with fair and constructive criticism; appropriate reviews may take place from time to time, and we would support continued review and improvement of the IARC processes. However, as a group of international scientists, we have looked carefully at the recent charges of flaws and bias in the hazard evaluations by IARC Working Groups, and we have concluded that the recent criticisms are unfair and unconstructive.</p><boxed-text position="float"><caption><title>Appendix 1: Classification Categories for the Overall Evaluation for the IARC Monographs (<xref rid="r18" ref-type="bibr">IARC 2006</xref>)</title></caption><p><bold>Group 1: The agent is <italic>carcinogenic to human</italic>s.</bold></p><p>This category is used when there is sufficient evidence of carcinogenicity in humans. Exceptionally, an agent may be placed in this category when evidence of carcinogenicity in humans is less than sufficient but there is sufficient evidence of carcinogenicity in experimental animals and strong evidence in exposed humans that the agent acts through a relevant mechanism of carcinogenicity.</p><p><bold>Group 2.</bold></p><p>This category includes agents for which, at one extreme, the degree of evidence of carcinogenicity in humans is almost <italic>sufficient</italic>, as well as those for which, at the other extreme, there are no human data but for which there is evidence of carcinogenicity in experimental animals. Agents are assigned to either Group 2A (<italic>probably carcinogenic to humans</italic>) or Group 2B (<italic>possibly carcinogenic to humans</italic>) on the basis of epidemiological and experimental evidence of carcinogenicity and mechanistic and other relevant data. The terms <italic>probably carcinogenic</italic> and <italic>possibly carcinogenic</italic> have no quantitative significance and are used simply as descriptors of different levels of evidence of human carcinogenicity, with <italic>probably carcinogenic</italic> signifying a higher level of evidence than <italic>possibly carcinogenic</italic>.</p><p><bold>Group 2A: The agent is <italic>probably carcinogenic to humans.</italic></bold></p><p>This category is used when there is <italic>limited evidence of carcinogenicity</italic> in humans and <italic>sufficient evidence of carcinogenicity</italic> in experimental animals. In some cases, an agent may be classified in this category when there is <italic>inadequate evidence of carcinogenicity</italic> in humans and <italic>sufficient evidence of carcinogenicity</italic> in experimental animals and strong evidence that the carcinogenesis is mediated by a mechanism that also operates in humans. Exceptionally, an agent may be classified in this category solely on the basis of <italic>limited evidence of carcinogenicity</italic> in humans. An agent may be assigned to this category if it clearly belongs, based on mechanistic considerations, to a class of agents for which one or more members have been classified in Group 1 or Group 2A.</p><p><bold>Group 2B: The agent is <italic>possibly carcinogenic to humans</italic>.</bold></p><p>This category is used for agents for which there is <italic>limited evidence of carcinogenicity</italic> in humans and less than <italic>sufficient evidence of carcinogenicity</italic> in experimental animals. It may also be used when there is <italic>inadequate evidence of carcinogenicity</italic> in humans but there is <italic>sufficient evidence of carcinogenicity</italic> in experimental animals. In some instances, an agent for which there is <italic>inadequate evidence of carcinogenicity</italic> in humans and less than <italic>sufficient evidence of carcinogenicity</italic> in experimental animals together with supporting evidence from mechanistic and other relevant data may be placed in this group. An agent may be classified in this category solely on the basis of strong evidence from mechanistic and other relevant data.</p><p><bold>Group 3: The agent is <italic>not classifiable as to its carcinogenicity to humans</italic>.</bold></p><p>This category is used most commonly for agents for which the evidence of carcinogenicity is <italic>inadequate</italic> in humans and <italic>inadequate</italic> or <italic>limited</italic> in experimental animals.</p><p>Exceptionally, agents for which the evidence of carcinogenicity is <italic>inadequate</italic> in humans but <italic>sufficient</italic> in experimental animals may be placed in this category when there is strong evidence that the mechanism of carcinogenicity in experimental animals does not operate in humans.</p><p>Agents that do not fall into any other group are also placed in this category.</p><p>An evaluation in Group 3 is not a determination of noncarcinogenicity or overall safety. It often means that further research is needed, especially when exposures are widespread or the cancer data are consistent with differing interpretations.</p><p><bold>Group 4: The agent is <italic>probably not carcinogenic to humans</italic>.</bold></p><p>This category is used for agents for which there is <italic>evidence suggesting lack of carcinogenicity</italic> in humans and in experimental animals. In some instances, agents for which there is <italic>inadequate evidence of carcinogenicity</italic> in humans but <italic>evidence suggesting lack of carcinogenicity</italic> in experimental animals, consistently and strongly supported by a broad range of mechanistic and other relevant data, may be classified in this group.</p></boxed-text></sec></body><back><fn-group><fn fn-type="financial-disclosure"><p>This work was conducted with no direct funding, but was supported in part by the Intramural Research Program of the NIH (NCI and NIEHS).</p></fn><fn fn-type="conflict"><p>The views expressed are those of the authors and do not necessarily reflect the official views of the Uniformed Services University of the Health Sciences, the Department of Defense, or the U.S. Food and Drug Administration.</p></fn><fn fn-type="conflict"><p>M. Stenzel is employed by Exposure Assessment Applications LLC (Arlington, VA, USA). P. Stewart is employed by Stewart Exposure Assessments LLC (Arlington, VA, USA). S.H. Zahm is employed by Shelia Zahm Consulting (Hermon, ME, USA), and she has served as an expert witness for the plaintiffs in U.S. litigation involving polychlorinated biphenyls and non-Hodgkin lymphoma. J. Huff has served as an expert witness for plaintiffs in U.S. litigation involving exposures to acrylamide and to styrene and carcinogenicity. B. Armstrong was formerly Deputy Director of IARC (1991–1993), and J. Huff and H. Vainio have previously served as head of the IARC Monographs Program. Most (but not all) other authors have served on IARC Monograph Working groups, and several have worked for IARC in the past. Although P. Bertazzi is Director of a Department that has research and consultancy contracts with industry (including petrochemical, plastics, iron, and steel, and other chemicals), as well as governmental, private, and nonprofit agencies, he has no affiliation with industry; he has served in Italy as an expert in medical legal cases involving asbestos exposure and asbestos-induced disease and prepared reports on causation and diagnosis of asbestos-related disorders for courts. D. Christiani, J. Dement, and A. Smith have served as expert witnesses in U.S. litigation involving asbestos exposure and disease outcomes, including cancer. E. Fontham is a Senior Research Fellow at the International Prevention Research Institute. P. Comba, P. Forastiere, E. Merler, F. Merletti, R. Pirastu, B. Terracini, and P. Vineis have acted as consultants to prosecutors and judges in a number of court case trials. F. Mirer has received compensation as a consultant to the AFL-CIO and the UAW in support of litigation. E. Weiderpass is currently a member of the IARC Scientific Council. 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