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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium</title><author><name sortKey="Agarwal, D" sort="Agarwal, D" uniqKey="Agarwal D" first="D" last="Agarwal">D. Agarwal</name><affiliation><nlm:aff id="aff1"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Department of Molecular, Cellular and Developmental Biology, Yale University</institution>, New Haven, CT,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Pineda, S" sort="Pineda, S" uniqKey="Pineda S" first="S" last="Pineda">S. Pineda</name><affiliation><nlm:aff id="aff1"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Michailidou, K" sort="Michailidou, K" uniqKey="Michailidou K" first="K" last="Michailidou">K. Michailidou</name><affiliation><nlm:aff id="aff3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Herranz, J" sort="Herranz, J" uniqKey="Herranz J" first="J" last="Herranz">J. Herranz</name><affiliation><nlm:aff id="aff1"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Biostatistics Unit, IMDEA Food Institute</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Pita, G" sort="Pita, G" uniqKey="Pita G" first="G" last="Pita">G. Pita</name><affiliation><nlm:aff id="aff5"><institution>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Moreno, L T" sort="Moreno, L T" uniqKey="Moreno L" first="L T" last="Moreno">L T Moreno</name><affiliation><nlm:aff id="aff5"><institution>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Alonso, M R" sort="Alonso, M R" uniqKey="Alonso M" first="M R" last="Alonso">M R Alonso</name><affiliation><nlm:aff id="aff5"><institution>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Dennis, J" sort="Dennis, J" uniqKey="Dennis J" first="J" last="Dennis">J. Dennis</name><affiliation><nlm:aff id="aff3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Q" sort="Wang, Q" uniqKey="Wang Q" first="Q" last="Wang">Q. Wang</name><affiliation><nlm:aff id="aff3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Bolla, M K" sort="Bolla, M K" uniqKey="Bolla M" first="M K" last="Bolla">M K Bolla</name><affiliation><nlm:aff id="aff3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Meyer, K B" sort="Meyer, K B" uniqKey="Meyer K" first="K B" last="Meyer">K B Meyer</name><affiliation><nlm:aff id="aff6"><institution>CRUK Cambridge Institute, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Menendez Rodriguez, P" sort="Menendez Rodriguez, P" uniqKey="Menendez Rodriguez P" first="P" last="Menéndez-Rodríguez">P. Menéndez-Rodríguez</name><affiliation><nlm:aff id="aff7"><institution>Hospital Monte Naranco</institution>, Oviedo,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Hardisson, D" sort="Hardisson, D" uniqKey="Hardisson D" first="D" last="Hardisson">D. Hardisson</name><affiliation><nlm:aff id="aff8"><institution>Department of Pathology, Hospital Universitario La Paz, IdiPAZ (Hospital La Paz Institute for Health Research) Universidad Autonoma de Madrid</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Mendiola, M" sort="Mendiola, M" uniqKey="Mendiola M" first="M" last="Mendiola">M. Mendiola</name><affiliation><nlm:aff id="aff9"><institution>Laboratory of Pathology and Oncology, Research Unit, Hospital Universitario La Paz, IdiPAZ</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, A" sort="Gonzalez Neira, A" uniqKey="Gonzalez Neira A" first="A" last="González-Neira">A. González-Neira</name><affiliation><nlm:aff id="aff5"><institution>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Lindblom, A" sort="Lindblom, A" uniqKey="Lindblom A" first="A" last="Lindblom">A. Lindblom</name><affiliation><nlm:aff id="aff10"><institution>Department of Molecular Medicine and Surgery, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Margolin, S" sort="Margolin, S" uniqKey="Margolin S" first="S" last="Margolin">S. Margolin</name><affiliation><nlm:aff id="aff11"><institution>Department of Oncology—Pathology, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Swerdlow, A" sort="Swerdlow, A" uniqKey="Swerdlow A" first="A" last="Swerdlow">A. Swerdlow</name><affiliation><nlm:aff id="aff12"><institution>Division of Genetics and Epidemiology, The Institute of Cancer Research</institution>, Sutton,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff13"><institution>Division of Breast Cancer Research, The Institute of Cancer Research</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Ashworth, A" sort="Ashworth, A" uniqKey="Ashworth A" first="A" last="Ashworth">A. Ashworth</name><affiliation><nlm:aff id="aff14"><institution>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Orr, N" sort="Orr, N" uniqKey="Orr N" first="N" last="Orr">N. Orr</name><affiliation><nlm:aff id="aff14"><institution>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Jones, M" sort="Jones, M" uniqKey="Jones M" first="M" last="Jones">M. Jones</name><affiliation><nlm:aff id="aff12"><institution>Division of Genetics and Epidemiology, The Institute of Cancer Research</institution>, Sutton,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Matsuo, K" sort="Matsuo, K" uniqKey="Matsuo K" first="K" last="Matsuo">K. Matsuo</name><affiliation><nlm:aff id="aff15"><institution>Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences</institution>, Fukuoka,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ito, H" sort="Ito, H" uniqKey="Ito H" first="H" last="Ito">H. Ito</name><affiliation><nlm:aff id="aff16"><institution>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute</institution>, Nagoya,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Iwata, H" sort="Iwata, H" uniqKey="Iwata H" first="H" last="Iwata">H. Iwata</name><affiliation><nlm:aff id="aff17"><institution>Department of Breast Oncology, Aichi Cancer Center Hospital</institution>, Nagoya,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kondo, N" sort="Kondo, N" uniqKey="Kondo N" first="N" last="Kondo">N. Kondo</name><affiliation><nlm:aff id="aff17"><institution>Department of Breast Oncology, Aichi Cancer Center Hospital</institution>, Nagoya,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Hartman, M" sort="Hartman, M" uniqKey="Hartman M" first="M" last="Hartman">M. Hartman</name><affiliation><nlm:aff id="aff20"><institution>Saw Swee Hock School of Public Health, Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System</institution>, Singapore,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Hui, M" sort="Hui, M" uniqKey="Hui M" first="M" last="Hui">M. Hui</name><affiliation><nlm:aff id="aff21"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</institution>, Singapore,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Lim, W Y" sort="Lim, W Y" uniqKey="Lim W" first="W Y" last="Lim">W Y Lim</name><affiliation><nlm:aff id="aff21"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</institution>, Singapore,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="T C Iau, P" sort="T C Iau, P" uniqKey="T C Iau P" first="P" last="T-C Iau">P. T-C Iau</name><affiliation><nlm:aff id="aff22"><institution>Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System</institution>, Singapore,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Sawyer, E" sort="Sawyer, E" uniqKey="Sawyer E" first="E" last="Sawyer">E. Sawyer</name><affiliation><nlm:aff id="aff23"><institution>Research Oncology, Division of Cancer Studies, Kings College London Guy's Hospital</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Tomlinson, I" sort="Tomlinson, I" uniqKey="Tomlinson I" first="I" last="Tomlinson">I. Tomlinson</name><affiliation><nlm:aff id="aff24"><institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>, Oxford,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff25"><institution>Oxford Biomedical Research Centre, University of Oxford</institution>, Oxford,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kerin, M" sort="Kerin, M" uniqKey="Kerin M" first="M" last="Kerin">M. Kerin</name><affiliation><nlm:aff id="aff26"><institution>School of Medicine, Clinical Science Institute, National University of Ireland</institution>, Galway,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Miller, N" sort="Miller, N" uniqKey="Miller N" first="N" last="Miller">N. Miller</name><affiliation><nlm:aff id="aff26"><institution>School of Medicine, Clinical Science Institute, National University of Ireland</institution>, Galway,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kang, D" sort="Kang, D" uniqKey="Kang D" first="D" last="Kang">D. Kang</name><affiliation><nlm:aff id="aff27"><institution>Department of Preventive Medicine, Seoul National University College of Medicine</institution>, Seoul,<country>Korea</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff28"><institution>Department of Biomedical Sciences, Seoul National University Graduate School</institution>, Seoul,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Choi, J Y" sort="Choi, J Y" uniqKey="Choi J" first="J-Y" last="Choi">J-Y Choi</name><affiliation><nlm:aff id="aff28"><institution>Department of Biomedical Sciences, Seoul National University Graduate School</institution>, Seoul,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Park, S K" sort="Park, S K" uniqKey="Park S" first="S K" last="Park">S K Park</name><affiliation><nlm:aff id="aff27"><institution>Department of Preventive Medicine, Seoul National University College of Medicine</institution>, Seoul,<country>Korea</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff28"><institution>Department of Biomedical Sciences, Seoul National University Graduate School</institution>, Seoul,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Noh, D Y" sort="Noh, D Y" uniqKey="Noh D" first="D-Y" last="Noh">D-Y Noh</name><affiliation><nlm:aff id="aff29"><institution>Department of Surgery, Seoul National University College of Medicine</institution>, Seoul,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Hopper, J L" sort="Hopper, J L" uniqKey="Hopper J" first="J L" last="Hopper">J L Hopper</name><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Schmidt, D F" sort="Schmidt, D F" uniqKey="Schmidt D" first="D F" last="Schmidt">D F Schmidt</name><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Makalic, E" sort="Makalic, E" uniqKey="Makalic E" first="E" last="Makalic">E. Makalic</name><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Southey, M C" sort="Southey, M C" uniqKey="Southey M" first="M C" last="Southey">M C Southey</name><affiliation><nlm:aff id="aff31"><institution>Department of Pathology, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Teo, S H" sort="Teo, S H" uniqKey="Teo S" first="S H" last="Teo">S H Teo</name><affiliation><nlm:aff id="aff32"><institution>Cancer Research Initiatives Foundation, Sime Darby Medical Centre</institution>, Subang Jaya,<country>Malaysia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff33"><institution>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre</institution>, Kuala Lumpur,<country>Malaysia</country></nlm:aff></affiliation></author><author><name sortKey="Yip, C H" sort="Yip, C H" uniqKey="Yip C" first="C H" last="Yip">C H Yip</name><affiliation><nlm:aff id="aff33"><institution>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre</institution>, Kuala Lumpur,<country>Malaysia</country></nlm:aff></affiliation></author><author><name sortKey="Sivanandan, K" sort="Sivanandan, K" uniqKey="Sivanandan K" first="K" last="Sivanandan">K. Sivanandan</name><affiliation><nlm:aff id="aff32"><institution>Cancer Research Initiatives Foundation, Sime Darby Medical Centre</institution>, Subang Jaya,<country>Malaysia</country></nlm:aff></affiliation></author><author><name sortKey="Tay, W T" sort="Tay, W T" uniqKey="Tay W" first="W-T" last="Tay">W-T Tay</name><affiliation><nlm:aff id="aff34"><institution>Singapore Eye Research Institute, National University of Singapore</institution>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Brauch, H" sort="Brauch, H" uniqKey="Brauch H" first="H" last="Brauch">H. Brauch</name><affiliation><nlm:aff id="aff35"><institution>Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology</institution>, Stuttgart,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff36"><institution>University of Tübingen</institution>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Bruning, T" sort="Bruning, T" uniqKey="Bruning T" first="T" last="Brüning">T. Brüning</name><affiliation><nlm:aff id="aff37"><institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA)</institution>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Hamann, U" sort="Hamann, U" uniqKey="Hamann U" first="U" last="Hamann">U. Hamann</name><affiliation><nlm:aff id="aff38"><institution>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg</institution>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dunning, A M" sort="Dunning, A M" uniqKey="Dunning A" first="A M" last="Dunning">A M Dunning</name><affiliation><nlm:aff id="aff42"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Shah, M" sort="Shah, M" uniqKey="Shah M" first="M" last="Shah">M. Shah</name><affiliation><nlm:aff id="aff42"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Andrulis, I L" sort="Andrulis, I L" uniqKey="Andrulis I" first="I L" last="Andrulis">I L Andrulis</name><affiliation><nlm:aff id="aff43"><institution>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff44"><institution>Department of Molecular Genetics, University of Toronto</institution>, Toronto, Ontario,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Knight, J A" sort="Knight, J A" uniqKey="Knight J" first="J A" last="Knight">J A Knight</name><affiliation><nlm:aff id="aff43"><institution>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff45"><institution>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto</institution>, Toronto, Ontario,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Glendon, G" sort="Glendon, G" uniqKey="Glendon G" first="G" last="Glendon">G. Glendon</name><affiliation><nlm:aff id="aff46"><institution>Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute</institution>, Toronto, Ontario,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Tchatchou, S" sort="Tchatchou, S" uniqKey="Tchatchou S" first="S" last="Tchatchou">S. Tchatchou</name><affiliation><nlm:aff id="aff43"><institution>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Schmidt, M K" sort="Schmidt, M K" uniqKey="Schmidt M" first="M K" last="Schmidt">M K Schmidt</name><affiliation><nlm:aff id="aff47"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Broeks, A" sort="Broeks, A" uniqKey="Broeks A" first="A" last="Broeks">A. Broeks</name><affiliation><nlm:aff id="aff47"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Rosenberg, E H" sort="Rosenberg, E H" uniqKey="Rosenberg E" first="E H" last="Rosenberg">E H Rosenberg</name><affiliation><nlm:aff id="aff47"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van T Veer, L J" sort="Van T Veer, L J" uniqKey="Van T Veer L" first="L J" last="Van'T Veer">L J Van'T Veer</name><affiliation><nlm:aff id="aff47"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Fasching, P A" sort="Fasching, P A" uniqKey="Fasching P" first="P A" last="Fasching">P A Fasching</name><affiliation><nlm:aff id="aff48"><institution>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, Erlangen,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff49"><institution>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles</institution>, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Renner, S P" sort="Renner, S P" uniqKey="Renner S" first="S P" last="Renner">S P Renner</name><affiliation><nlm:aff id="aff48"><institution>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, Erlangen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ekici, A B" sort="Ekici, A B" uniqKey="Ekici A" first="A B" last="Ekici">A B Ekici</name><affiliation><nlm:aff id="aff50"><institution>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg</institution>, Erlangen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Beckmann, M W" sort="Beckmann, M W" uniqKey="Beckmann M" first="M W" last="Beckmann">M W Beckmann</name><affiliation><nlm:aff id="aff48"><institution>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, Erlangen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Shen, C Y" sort="Shen, C Y" uniqKey="Shen C" first="C-Y" last="Shen">C-Y Shen</name><affiliation><nlm:aff id="aff51"><institution>Institute of Biomedical Sciences, Academia Sinica</institution>, Taipei,<country>Taiwan</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff52"><institution>College of Public Health, China Medical University</institution>, Taichong,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Hsiung, C N" sort="Hsiung, C N" uniqKey="Hsiung C" first="C-N" last="Hsiung">C-N Hsiung</name><affiliation><nlm:aff id="aff51"><institution>Institute of Biomedical Sciences, Academia Sinica</institution>, Taipei,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Yu, J C" sort="Yu, J C" uniqKey="Yu J" first="J-C" last="Yu">J-C Yu</name><affiliation><nlm:aff id="aff53"><institution>Tri-Service General Hospital</institution>, Taipei,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Hou, M F" sort="Hou, M F" uniqKey="Hou M" first="M-F" last="Hou">M-F Hou</name><affiliation><nlm:aff id="aff54"><institution>Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital</institution>, Kaohsiung,<country>Taiwan</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff55"><institution>Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital</institution>, Kaohsiung,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Blot, W" sort="Blot, W" uniqKey="Blot W" first="W" last="Blot">W. Blot</name><affiliation><nlm:aff id="aff56"><institution>Department of Medicine, Vanderbilt University</institution>, Nashville,<country>TN USA</country></nlm:aff></affiliation></author><author><name sortKey="Cai, Q" sort="Cai, Q" uniqKey="Cai Q" first="Q" last="Cai">Q. Cai</name><affiliation><nlm:aff id="aff56"><institution>Department of Medicine, Vanderbilt University</institution>, Nashville,<country>TN USA</country></nlm:aff></affiliation></author><author><name sortKey="Wu, A H" sort="Wu, A H" uniqKey="Wu A" first="A H" last="Wu">A H Wu</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Tseng, C C" sort="Tseng, C C" uniqKey="Tseng C" first="C-C" last="Tseng">C-C Tseng</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, D" sort="Van Den Berg, D" uniqKey="Van Den Berg D" first="D" last="Van Den Berg">D. Van Den Berg</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Stram, D O" sort="Stram, D O" uniqKey="Stram D" first="D O" last="Stram">D O Stram</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Cox, A" sort="Cox, A" uniqKey="Cox A" first="A" last="Cox">A. Cox</name><affiliation><nlm:aff id="aff58"><institution>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield</institution>, Sheffield,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Brock, I W" sort="Brock, I W" uniqKey="Brock I" first="I W" last="Brock">I W Brock</name><affiliation><nlm:aff id="aff58"><institution>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield</institution>, Sheffield,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Reed, M W R" sort="Reed, M W R" uniqKey="Reed M" first="M W R" last="Reed">M W R. Reed</name><affiliation><nlm:aff id="aff58"><institution>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield</institution>, Sheffield,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Muir, K" sort="Muir, K" uniqKey="Muir K" first="K" last="Muir">K. Muir</name><affiliation><nlm:aff id="aff59"><institution>Institute of Population Health, University of Manchester</institution>, Manchester,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff60"><institution>Division of Health Sciences, Warwick Medical School</institution>, Coventry,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Lophatananon, A" sort="Lophatananon, A" uniqKey="Lophatananon A" first="A" last="Lophatananon">A. Lophatananon</name><affiliation><nlm:aff id="aff60"><institution>Division of Health Sciences, Warwick Medical School</institution>, Coventry,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Stewart Brown, S" sort="Stewart Brown, S" uniqKey="Stewart Brown S" first="S" last="Stewart-Brown">S. Stewart-Brown</name><affiliation><nlm:aff id="aff60"><institution>Division of Health Sciences, Warwick Medical School</institution>, Coventry,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Siriwanarangsan, P" sort="Siriwanarangsan, P" uniqKey="Siriwanarangsan P" first="P" last="Siriwanarangsan">P. Siriwanarangsan</name><affiliation><nlm:aff id="aff61"><institution>Ministry of Public Health</institution>, Bangkok,<country>Thailand</country></nlm:aff></affiliation></author><author><name sortKey="Zheng, W" sort="Zheng, W" uniqKey="Zheng W" first="W" last="Zheng">W. Zheng</name><affiliation><nlm:aff id="aff62"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center</institution>, Nashville, TN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Deming Halverson, S" sort="Deming Halverson, S" uniqKey="Deming Halverson S" first="S" last="Deming-Halverson">S. Deming-Halverson</name><affiliation><nlm:aff id="aff62"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center</institution>, Nashville, TN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Shrubsole, M J" sort="Shrubsole, M J" uniqKey="Shrubsole M" first="M J" last="Shrubsole">M J Shrubsole</name><affiliation><nlm:aff id="aff62"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center</institution>, Nashville, TN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Long, J" sort="Long, J" uniqKey="Long J" first="J" last="Long">J. Long</name><affiliation><nlm:aff id="aff62"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center</institution>, Nashville, TN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Shu, X O" sort="Shu, X O" uniqKey="Shu X" first="X-O" last="Shu">X-O Shu</name><affiliation><nlm:aff id="aff62"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center</institution>, Nashville, TN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lu, W" sort="Lu, W" uniqKey="Lu W" first="W" last="Lu">W. Lu</name><affiliation><nlm:aff id="aff63"><institution>Shanghai Center for Disease Control and Prevention</institution>, Shanghai,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Gao, Y T" sort="Gao, Y T" uniqKey="Gao Y" first="Y-T" last="Gao">Y-T Gao</name><affiliation><nlm:aff id="aff64"><institution>Shanghai Cancer Institute</institution>, Shanghai,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Zhang, B" sort="Zhang, B" uniqKey="Zhang B" first="B" last="Zhang">B. Zhang</name><affiliation><nlm:aff id="aff62"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center</institution>, Nashville, TN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Radice, P" sort="Radice, P" uniqKey="Radice P" first="P" last="Radice">P. Radice</name><affiliation><nlm:aff id="aff65"><institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>, Milan,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Peterlongo, P" sort="Peterlongo, P" uniqKey="Peterlongo P" first="P" last="Peterlongo">P. Peterlongo</name><affiliation><nlm:aff id="aff66"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>, Milan,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Manoukian, S" sort="Manoukian, S" uniqKey="Manoukian S" first="S" last="Manoukian">S. Manoukian</name><affiliation><nlm:aff id="aff67"><institution>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>, Milan,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Mariette, F" sort="Mariette, F" uniqKey="Mariette F" first="F" last="Mariette">F. Mariette</name><affiliation><nlm:aff id="aff66"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>, Milan,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff68"><institution>Cogentech Cancer Genetic Test Laboratory</institution>, Milan,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, S" sort="Sangrajrang, S" uniqKey="Sangrajrang S" first="S" last="Sangrajrang">S. Sangrajrang</name><affiliation><nlm:aff id="aff69"><institution>National Cancer Institute</institution>, Bangkok,<country>Thailand</country></nlm:aff></affiliation></author><author><name sortKey="Mckay, J" sort="Mckay, J" uniqKey="Mckay J" first="J" last="Mckay">J. Mckay</name><affiliation><nlm:aff id="aff70"><institution>Genetic Susceptibility Group, International Agency for Research on Cancer</institution>, Lyon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Couch, F J" sort="Couch, F J" uniqKey="Couch F" first="F J" last="Couch">F J Couch</name><affiliation><nlm:aff id="aff71"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Toland, A E" sort="Toland, A E" uniqKey="Toland A" first="A E" last="Toland">A E Toland</name><affiliation><nlm:aff id="aff72"><institution>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University</institution>, Columbus, OH,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, D" sort="Yannoukakos, D" uniqKey="Yannoukakos D" first="D" last="Yannoukakos">D. Yannoukakos</name><affiliation><nlm:aff id="aff74"><institution>Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos"</institution>, Athens,<country>Greece</country></nlm:aff></affiliation></author><author><name sortKey="Fletcher, O" sort="Fletcher, O" uniqKey="Fletcher O" first="O" last="Fletcher">O. Fletcher</name><affiliation><nlm:aff id="aff75"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Johnson, N" sort="Johnson, N" uniqKey="Johnson N" first="N" last="Johnson">N. Johnson</name><affiliation><nlm:aff id="aff75"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Silva, I Dos Santos" sort="Silva, I Dos Santos" uniqKey="Silva I" first="I Dos Santos" last="Silva">I Dos Santos Silva</name><affiliation><nlm:aff id="aff76"><institution>London School of Hygiene and Tropical Medicine</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Peto, J" sort="Peto, J" uniqKey="Peto J" first="J" last="Peto">J. Peto</name><affiliation><nlm:aff id="aff76"><institution>London School of Hygiene and Tropical Medicine</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Marme, F" sort="Marme, F" uniqKey="Marme F" first="F" last="Marme">F. Marme</name><affiliation><nlm:aff id="aff77"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff78"><institution>National Center for Tumor Diseases, University of Heidelberg</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Burwinkel, B" sort="Burwinkel, B" uniqKey="Burwinkel B" first="B" last="Burwinkel">B. Burwinkel</name><affiliation><nlm:aff id="aff77"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff79"><institution>Molecular Epidemiology Group, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Guenel, P" sort="Guenel, P" uniqKey="Guenel P" first="P" last="Guénel">P. Guénel</name><affiliation><nlm:aff id="aff80"><institution>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer</institution>, Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff81"><institution>University Paris-Sud, UMRS 1018</institution>, Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Truong, T" sort="Truong, T" uniqKey="Truong T" first="T" last="Truong">T. Truong</name><affiliation><nlm:aff id="aff80"><institution>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer</institution>, Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff81"><institution>University Paris-Sud, UMRS 1018</institution>, Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Sanchez, M" sort="Sanchez, M" uniqKey="Sanchez M" first="M" last="Sanchez">M. Sanchez</name><affiliation><nlm:aff id="aff80"><institution>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer</institution>, Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff81"><institution>University Paris-Sud, UMRS 1018</institution>, Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mulot, C" sort="Mulot, C" uniqKey="Mulot C" first="C" last="Mulot">C. Mulot</name><affiliation><nlm:aff id="aff82"><institution>Inserm (National Institute of Health and Medical Research)</institution>, U775 Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff83"><institution>Centre de Ressources Biologiques EPIGENETEC</institution>, Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bojesen, S E" sort="Bojesen, S E" uniqKey="Bojesen S" first="S E" last="Bojesen">S E Bojesen</name><affiliation><nlm:aff id="aff84"><institution>Copenhagen General Population Study, Herlev University Hospital, University of Copenhagen</institution>, Copenhagen,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff85"><institution>Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen</institution>, Copenhagen,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B G" sort="Nordestgaard, B G" uniqKey="Nordestgaard B" first="B G" last="Nordestgaard">B G Nordestgaard</name><affiliation><nlm:aff id="aff84"><institution>Copenhagen General Population Study, Herlev University Hospital, University of Copenhagen</institution>, Copenhagen,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff85"><institution>Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen</institution>, Copenhagen,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Flyer, H" sort="Flyer, H" uniqKey="Flyer H" first="H" last="Flyer">H. Flyer</name><affiliation><nlm:aff id="aff86"><institution>Department of Breast Surgery, Herlev University Hospital, University of Copenhagen</institution>, Copenhagen,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Brenner, H" sort="Brenner, H" uniqKey="Brenner H" first="H" last="Brenner">H. Brenner</name><affiliation><nlm:aff id="aff87"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff88"><institution>German Cancer Consortium (DKTK)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, A K" sort="Dieffenbach, A K" uniqKey="Dieffenbach A" first="A K" last="Dieffenbach">A K Dieffenbach</name><affiliation><nlm:aff id="aff87"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff88"><institution>German Cancer Consortium (DKTK)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Arndt, V" sort="Arndt, V" uniqKey="Arndt V" first="V" last="Arndt">V. Arndt</name><affiliation><nlm:aff id="aff87"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Stegmaier, C" sort="Stegmaier, C" uniqKey="Stegmaier C" first="C" last="Stegmaier">C. Stegmaier</name><affiliation><nlm:aff id="aff89"><institution>Saarland Cancer Registry</institution>, Saarbrücken,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Mannermaa, A" sort="Mannermaa, A" uniqKey="Mannermaa A" first="A" last="Mannermaa">A. Mannermaa</name><affiliation><nlm:aff id="aff90"><institution>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff91"><institution>Biocenter Kuopio, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff92"><institution>Department of Clinical Pathology, Kuopio University Hospital</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Kataja, V" sort="Kataja, V" uniqKey="Kataja V" first="V" last="Kataja">V. Kataja</name><affiliation><nlm:aff id="aff91"><institution>Biocenter Kuopio, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff93"><institution>School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff94"><institution>Cancer Center, Kuopio University Hospital</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Kosma, V M" sort="Kosma, V M" uniqKey="Kosma V" first="V-M" last="Kosma">V-M Kosma</name><affiliation><nlm:aff id="aff90"><institution>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff91"><institution>Biocenter Kuopio, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff92"><institution>Department of Clinical Pathology, Kuopio University Hospital</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Hartikainen, J M" sort="Hartikainen, J M" uniqKey="Hartikainen J" first="J M" last="Hartikainen">J M Hartikainen</name><affiliation><nlm:aff id="aff90"><institution>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff91"><institution>Biocenter Kuopio, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff92"><institution>Department of Clinical Pathology, Kuopio University Hospital</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Lambrechts, D" sort="Lambrechts, D" uniqKey="Lambrechts D" first="D" last="Lambrechts">D. Lambrechts</name><affiliation><nlm:aff id="aff95"><institution>Vesalius Research Center (VRC), VIB</institution>, Leuven,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Yesilyurt, B T" sort="Yesilyurt, B T" uniqKey="Yesilyurt B" first="B T" last="Yesilyurt">B T Yesilyurt</name><affiliation><nlm:aff id="aff95"><institution>Vesalius Research Center (VRC), VIB</institution>, Leuven,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Floris, G" sort="Floris, G" uniqKey="Floris G" first="G" last="Floris">G. Floris</name><affiliation><nlm:aff id="aff96"><institution>Multidisciplinary Breast Center, University Hospital Gasthuisberg</institution>, Leuven,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Leunen, K" sort="Leunen, K" uniqKey="Leunen K" first="K" last="Leunen">K. Leunen</name><affiliation><nlm:aff id="aff96"><institution>Multidisciplinary Breast Center, University Hospital Gasthuisberg</institution>, Leuven,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Chang Claude, J" sort="Chang Claude, J" uniqKey="Chang Claude J" first="J" last="Chang-Claude">J. Chang-Claude</name><affiliation><nlm:aff id="aff97"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Rudolph, A" sort="Rudolph, A" uniqKey="Rudolph A" first="A" last="Rudolph">A. Rudolph</name><affiliation><nlm:aff id="aff97"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Seibold, P" sort="Seibold, P" uniqKey="Seibold P" first="P" last="Seibold">P. Seibold</name><affiliation><nlm:aff id="aff97"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, D" sort="Flesch Janys, D" uniqKey="Flesch Janys D" first="D" last="Flesch-Janys">D. Flesch-Janys</name><affiliation><nlm:aff id="aff98"><institution>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf</institution>, Hamburg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff99"><institution>Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf</institution>, Hamburg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Wang, X" sort="Wang, X" uniqKey="Wang X" first="X" last="Wang">X. Wang</name><affiliation><nlm:aff id="aff71"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Olson, J E" sort="Olson, J E" uniqKey="Olson J" first="J E" last="Olson">J E Olson</name><affiliation><nlm:aff id="aff100"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Vachon, C" sort="Vachon, C" uniqKey="Vachon C" first="C" last="Vachon">C. Vachon</name><affiliation><nlm:aff id="aff100"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Purrington, K" sort="Purrington, K" uniqKey="Purrington K" first="K" last="Purrington">K. Purrington</name><affiliation><nlm:aff id="aff100"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Giles, G G" sort="Giles, G G" uniqKey="Giles G" first="G G" last="Giles">G G Giles</name><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff101"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Severi, G" sort="Severi, G" uniqKey="Severi G" first="G" last="Severi">G. Severi</name><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff101"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Baglietto, L" sort="Baglietto, L" uniqKey="Baglietto L" first="L" last="Baglietto">L. Baglietto</name><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff101"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Haiman, C A" sort="Haiman, C A" uniqKey="Haiman C" first="C A" last="Haiman">C A Haiman</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Henderson, B E" sort="Henderson, B E" uniqKey="Henderson B" first="B E" last="Henderson">B E Henderson</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Schumacher, F" sort="Schumacher, F" uniqKey="Schumacher F" first="F" last="Schumacher">F. Schumacher</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Le Marchand, L" sort="Le Marchand, L" uniqKey="Le Marchand L" first="L" last="Le Marchand">L. Le Marchand</name><affiliation><nlm:aff id="aff102"><institution>University of Hawaii Cancer Center</institution>, Honolulu, HI,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Simard, J" sort="Simard, J" uniqKey="Simard J" first="J" last="Simard">J. Simard</name><affiliation><nlm:aff id="aff103"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec Research Center and Laval University</institution>, Quebec,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Dumont, M" sort="Dumont, M" uniqKey="Dumont M" first="M" last="Dumont">M. Dumont</name><affiliation><nlm:aff id="aff103"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec Research Center and Laval University</institution>, Quebec,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Goldberg, M S" sort="Goldberg, M S" uniqKey="Goldberg M" first="M S" last="Goldberg">M S Goldberg</name><affiliation><nlm:aff id="aff104"><institution>Department of Medicine, McGill University, Montreal</institution>, Montreal, Quebec,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff105"><institution>Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital</institution>, Montreal, Quebec,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Labreche, F" sort="Labreche, F" uniqKey="Labreche F" first="F" last="Labrèche">F. Labrèche</name><affiliation><nlm:aff id="aff106"><institution>Département de médecine sociale et préventive, Département de santé environnementale et santé au travail, Université de Montréal</institution>, Montreal, Quebec,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Winqvist, R" sort="Winqvist, R" uniqKey="Winqvist R" first="R" last="Winqvist">R. Winqvist</name><affiliation><nlm:aff id="aff107"><institution>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital</institution>, Oulu,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Pylk S, K" sort="Pylk S, K" uniqKey="Pylk S K" first="K" last="Pylk S">K. Pylk S</name><affiliation><nlm:aff id="aff107"><institution>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital</institution>, Oulu,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, A" sort="Jukkola Vuorinen, A" uniqKey="Jukkola Vuorinen A" first="A" last="Jukkola-Vuorinen">A. Jukkola-Vuorinen</name><affiliation><nlm:aff id="aff108"><institution>Department of Oncology, Oulu University Hospital, University of Oulu</institution>, Oulu,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Grip, M" sort="Grip, M" uniqKey="Grip M" first="M" last="Grip">M. Grip</name><affiliation><nlm:aff id="aff109"><institution>Department of Surgery, Oulu University Hospital, University of Oulu</institution>, Oulu,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Devilee, P" sort="Devilee, P" uniqKey="Devilee P" first="P" last="Devilee">P. Devilee</name><affiliation><nlm:aff id="aff110"><institution>Department of Human Genetics, Leiden University Medical Center</institution>, Leiden,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Tollenaar, R A E M" sort="Tollenaar, R A E M" uniqKey="Tollenaar R" first="R A E M" last="Tollenaar">R A E M. Tollenaar</name><affiliation><nlm:aff id="aff111"><institution>Department of Surgical Oncology, Leiden University Medical Center</institution>, Leiden,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Seynaeve, C" sort="Seynaeve, C" uniqKey="Seynaeve C" first="C" last="Seynaeve">C. Seynaeve</name><affiliation><nlm:aff id="aff112"><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Centre</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, M" sort="Garcia Closas, M" uniqKey="Garcia Closas M" first="M" last="García-Closas">M. García-Closas</name><affiliation><nlm:aff id="aff13"><institution>Division of Breast Cancer Research, The Institute of Cancer Research</institution>, London,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff113"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, MD,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff114"><institution>Division of Genetics and Epidemiology, Institute of Cancer Research and Breakthrough Breast Cancer Research Centre</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Chanock, S J" sort="Chanock, S J" uniqKey="Chanock S" first="S J" last="Chanock">S J Chanock</name><affiliation><nlm:aff id="aff113"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, MD,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lissowska, J" sort="Lissowska, J" uniqKey="Lissowska J" first="J" last="Lissowska">J. Lissowska</name><affiliation><nlm:aff id="aff115"><institution>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>, Warsaw,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Figueroa, J D" sort="Figueroa, J D" uniqKey="Figueroa J" first="J D" last="Figueroa">J D Figueroa</name><affiliation><nlm:aff id="aff113"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, MD,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Czene, K" sort="Czene, K" uniqKey="Czene K" first="K" last="Czene">K. Czene</name><affiliation><nlm:aff id="aff116"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Eriksson, M" sort="Eriksson, M" uniqKey="Eriksson M" first="M" last="Eriksson">M. Eriksson</name><affiliation><nlm:aff id="aff116"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Humphreys, K" sort="Humphreys, K" uniqKey="Humphreys K" first="K" last="Humphreys">K. Humphreys</name><affiliation><nlm:aff id="aff116"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Darabi, H" sort="Darabi, H" uniqKey="Darabi H" first="H" last="Darabi">H. Darabi</name><affiliation><nlm:aff id="aff116"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Hooning, M J" sort="Hooning, M J" uniqKey="Hooning M" first="M J" last="Hooning">M J Hooning</name><affiliation><nlm:aff id="aff112"><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Centre</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Kriege, M" sort="Kriege, M" uniqKey="Kriege M" first="M" last="Kriege">M. Kriege</name><affiliation><nlm:aff id="aff112"><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Centre</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Collee, J M" sort="Collee, J M" uniqKey="Collee J" first="J M" last="Collée">J M Collée</name><affiliation><nlm:aff id="aff117"><institution>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Tilanus Linthorst, M" sort="Tilanus Linthorst, M" uniqKey="Tilanus Linthorst M" first="M" last="Tilanus-Linthorst">M. Tilanus-Linthorst</name><affiliation><nlm:aff id="aff118"><institution>Department of Surgical Oncology, Family Cancer Clinic, Erasmus University Medical Centre</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Li, J" sort="Li, J" uniqKey="Li J" first="J" last="Li">J. Li</name><affiliation><nlm:aff id="aff119"><institution>Human Genetics Division, Genome Institute of Singapore</institution>, Singapore,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Jakubowska, A" sort="Jakubowska, A" uniqKey="Jakubowska A" first="A" last="Jakubowska">A. Jakubowska</name><affiliation><nlm:aff id="aff120"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Lubinski, J" sort="Lubinski, J" uniqKey="Lubinski J" first="J" last="Lubinski">J. Lubinski</name><affiliation><nlm:aff id="aff120"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Jaworska Bieniek, K" sort="Jaworska Bieniek, K" uniqKey="Jaworska Bieniek K" first="K" last="Jaworska-Bieniek">K. Jaworska-Bieniek</name><affiliation><nlm:aff id="aff120"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Durda, K" sort="Durda, K" uniqKey="Durda K" first="K" last="Durda">K. Durda</name><affiliation><nlm:aff id="aff120"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, H" sort="Nevanlinna, H" uniqKey="Nevanlinna H" first="H" last="Nevanlinna">H. Nevanlinna</name><affiliation><nlm:aff id="aff121"><institution>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital</institution>, Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Muranen, T A" sort="Muranen, T A" uniqKey="Muranen T" first="T A" last="Muranen">T A Muranen</name><affiliation><nlm:aff id="aff121"><institution>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital</institution>, Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, K" sort="Aittom Ki, K" uniqKey="Aittom Ki K" first="K" last="Aittom Ki">K. Aittom Ki</name><affiliation><nlm:aff id="aff122"><institution>Department of Clinical Genetics, Helsinki University Central Hospital</institution>, Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Blomqvist, C" sort="Blomqvist, C" uniqKey="Blomqvist C" first="C" last="Blomqvist">C. Blomqvist</name><affiliation><nlm:aff id="aff123"><institution>Department of Oncology, Helsinki University Central Hospital</institution>, Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Bogdanova, N" sort="Bogdanova, N" uniqKey="Bogdanova N" first="N" last="Bogdanova">N. Bogdanova</name><affiliation><nlm:aff id="aff124"><institution>Department of Obstetrics and Gynaecology, Hannover Medical School</institution>, Hannover,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff125"><institution>Department of Radiation Oncology, Hannover Medical School</institution>, Hannover,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dork, T" sort="Dork, T" uniqKey="Dork T" first="T" last="Dörk">T. Dörk</name><affiliation><nlm:aff id="aff124"><institution>Department of Obstetrics and Gynaecology, Hannover Medical School</institution>, Hannover,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Hall, P" sort="Hall, P" uniqKey="Hall P" first="P" last="Hall">P. Hall</name><affiliation><nlm:aff id="aff116"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, G" sort="Chenevix Trench, G" uniqKey="Chenevix Trench G" first="G" last="Chenevix-Trench">G. Chenevix-Trench</name><affiliation><nlm:aff id="aff19"><institution>QIMR Berghofer Institute of Medical Research</institution>, Brisbane, Queensland,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Easton, D F" sort="Easton, D F" uniqKey="Easton D" first="D F" last="Easton">D F Easton</name><affiliation><nlm:aff id="aff3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff42"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Pharoah, P D P" sort="Pharoah, P D P" uniqKey="Pharoah P" first="P D P" last="Pharoah">P D P. 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Zamora</name><affiliation><nlm:aff id="aff127"><institution>Servicio de Oncología Médica, Hospital Universitario La Paz</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J" last="Benítez">J. Benítez</name><affiliation><nlm:aff id="aff1"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Milne, R L" sort="Milne, R L" uniqKey="Milne R" first="R L" last="Milne">R L Milne</name><affiliation><nlm:aff id="aff1"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff101"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne,<country>Australia</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24548884</idno><idno type="pmc">3929867</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929867</idno><idno type="RBID">PMC:3929867</idno><idno type="doi">10.1038/bjc.2013.769</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000085</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000085</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium</title><author><name sortKey="Agarwal, D" sort="Agarwal, D" uniqKey="Agarwal D" first="D" last="Agarwal">D. Agarwal</name><affiliation><nlm:aff id="aff1"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Department of Molecular, Cellular and Developmental Biology, Yale University</institution>, New Haven, CT,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Pineda, S" sort="Pineda, S" uniqKey="Pineda S" first="S" last="Pineda">S. Pineda</name><affiliation><nlm:aff id="aff1"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Michailidou, K" sort="Michailidou, K" uniqKey="Michailidou K" first="K" last="Michailidou">K. Michailidou</name><affiliation><nlm:aff id="aff3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Herranz, J" sort="Herranz, J" uniqKey="Herranz J" first="J" last="Herranz">J. Herranz</name><affiliation><nlm:aff id="aff1"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Biostatistics Unit, IMDEA Food Institute</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Pita, G" sort="Pita, G" uniqKey="Pita G" first="G" last="Pita">G. Pita</name><affiliation><nlm:aff id="aff5"><institution>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Moreno, L T" sort="Moreno, L T" uniqKey="Moreno L" first="L T" last="Moreno">L T Moreno</name><affiliation><nlm:aff id="aff5"><institution>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Alonso, M R" sort="Alonso, M R" uniqKey="Alonso M" first="M R" last="Alonso">M R Alonso</name><affiliation><nlm:aff id="aff5"><institution>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Dennis, J" sort="Dennis, J" uniqKey="Dennis J" first="J" last="Dennis">J. Dennis</name><affiliation><nlm:aff id="aff3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Q" sort="Wang, Q" uniqKey="Wang Q" first="Q" last="Wang">Q. Wang</name><affiliation><nlm:aff id="aff3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Bolla, M K" sort="Bolla, M K" uniqKey="Bolla M" first="M K" last="Bolla">M K Bolla</name><affiliation><nlm:aff id="aff3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Meyer, K B" sort="Meyer, K B" uniqKey="Meyer K" first="K B" last="Meyer">K B Meyer</name><affiliation><nlm:aff id="aff6"><institution>CRUK Cambridge Institute, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Menendez Rodriguez, P" sort="Menendez Rodriguez, P" uniqKey="Menendez Rodriguez P" first="P" last="Menéndez-Rodríguez">P. Menéndez-Rodríguez</name><affiliation><nlm:aff id="aff7"><institution>Hospital Monte Naranco</institution>, Oviedo,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Hardisson, D" sort="Hardisson, D" uniqKey="Hardisson D" first="D" last="Hardisson">D. Hardisson</name><affiliation><nlm:aff id="aff8"><institution>Department of Pathology, Hospital Universitario La Paz, IdiPAZ (Hospital La Paz Institute for Health Research) Universidad Autonoma de Madrid</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Mendiola, M" sort="Mendiola, M" uniqKey="Mendiola M" first="M" last="Mendiola">M. Mendiola</name><affiliation><nlm:aff id="aff9"><institution>Laboratory of Pathology and Oncology, Research Unit, Hospital Universitario La Paz, IdiPAZ</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, A" sort="Gonzalez Neira, A" uniqKey="Gonzalez Neira A" first="A" last="González-Neira">A. González-Neira</name><affiliation><nlm:aff id="aff5"><institution>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Lindblom, A" sort="Lindblom, A" uniqKey="Lindblom A" first="A" last="Lindblom">A. Lindblom</name><affiliation><nlm:aff id="aff10"><institution>Department of Molecular Medicine and Surgery, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Margolin, S" sort="Margolin, S" uniqKey="Margolin S" first="S" last="Margolin">S. Margolin</name><affiliation><nlm:aff id="aff11"><institution>Department of Oncology—Pathology, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Swerdlow, A" sort="Swerdlow, A" uniqKey="Swerdlow A" first="A" last="Swerdlow">A. Swerdlow</name><affiliation><nlm:aff id="aff12"><institution>Division of Genetics and Epidemiology, The Institute of Cancer Research</institution>, Sutton,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff13"><institution>Division of Breast Cancer Research, The Institute of Cancer Research</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Ashworth, A" sort="Ashworth, A" uniqKey="Ashworth A" first="A" last="Ashworth">A. Ashworth</name><affiliation><nlm:aff id="aff14"><institution>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Orr, N" sort="Orr, N" uniqKey="Orr N" first="N" last="Orr">N. Orr</name><affiliation><nlm:aff id="aff14"><institution>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Jones, M" sort="Jones, M" uniqKey="Jones M" first="M" last="Jones">M. Jones</name><affiliation><nlm:aff id="aff12"><institution>Division of Genetics and Epidemiology, The Institute of Cancer Research</institution>, Sutton,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Matsuo, K" sort="Matsuo, K" uniqKey="Matsuo K" first="K" last="Matsuo">K. Matsuo</name><affiliation><nlm:aff id="aff15"><institution>Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences</institution>, Fukuoka,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ito, H" sort="Ito, H" uniqKey="Ito H" first="H" last="Ito">H. Ito</name><affiliation><nlm:aff id="aff16"><institution>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute</institution>, Nagoya,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Iwata, H" sort="Iwata, H" uniqKey="Iwata H" first="H" last="Iwata">H. Iwata</name><affiliation><nlm:aff id="aff17"><institution>Department of Breast Oncology, Aichi Cancer Center Hospital</institution>, Nagoya,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Kondo, N" sort="Kondo, N" uniqKey="Kondo N" first="N" last="Kondo">N. Kondo</name><affiliation><nlm:aff id="aff17"><institution>Department of Breast Oncology, Aichi Cancer Center Hospital</institution>, Nagoya,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Hartman, M" sort="Hartman, M" uniqKey="Hartman M" first="M" last="Hartman">M. Hartman</name><affiliation><nlm:aff id="aff20"><institution>Saw Swee Hock School of Public Health, Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System</institution>, Singapore,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Hui, M" sort="Hui, M" uniqKey="Hui M" first="M" last="Hui">M. Hui</name><affiliation><nlm:aff id="aff21"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</institution>, Singapore,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Lim, W Y" sort="Lim, W Y" uniqKey="Lim W" first="W Y" last="Lim">W Y Lim</name><affiliation><nlm:aff id="aff21"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</institution>, Singapore,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="T C Iau, P" sort="T C Iau, P" uniqKey="T C Iau P" first="P" last="T-C Iau">P. T-C Iau</name><affiliation><nlm:aff id="aff22"><institution>Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System</institution>, Singapore,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Sawyer, E" sort="Sawyer, E" uniqKey="Sawyer E" first="E" last="Sawyer">E. Sawyer</name><affiliation><nlm:aff id="aff23"><institution>Research Oncology, Division of Cancer Studies, Kings College London Guy's Hospital</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Tomlinson, I" sort="Tomlinson, I" uniqKey="Tomlinson I" first="I" last="Tomlinson">I. Tomlinson</name><affiliation><nlm:aff id="aff24"><institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>, Oxford,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff25"><institution>Oxford Biomedical Research Centre, University of Oxford</institution>, Oxford,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kerin, M" sort="Kerin, M" uniqKey="Kerin M" first="M" last="Kerin">M. Kerin</name><affiliation><nlm:aff id="aff26"><institution>School of Medicine, Clinical Science Institute, National University of Ireland</institution>, Galway,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Miller, N" sort="Miller, N" uniqKey="Miller N" first="N" last="Miller">N. Miller</name><affiliation><nlm:aff id="aff26"><institution>School of Medicine, Clinical Science Institute, National University of Ireland</institution>, Galway,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kang, D" sort="Kang, D" uniqKey="Kang D" first="D" last="Kang">D. Kang</name><affiliation><nlm:aff id="aff27"><institution>Department of Preventive Medicine, Seoul National University College of Medicine</institution>, Seoul,<country>Korea</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff28"><institution>Department of Biomedical Sciences, Seoul National University Graduate School</institution>, Seoul,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Choi, J Y" sort="Choi, J Y" uniqKey="Choi J" first="J-Y" last="Choi">J-Y Choi</name><affiliation><nlm:aff id="aff28"><institution>Department of Biomedical Sciences, Seoul National University Graduate School</institution>, Seoul,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Park, S K" sort="Park, S K" uniqKey="Park S" first="S K" last="Park">S K Park</name><affiliation><nlm:aff id="aff27"><institution>Department of Preventive Medicine, Seoul National University College of Medicine</institution>, Seoul,<country>Korea</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff28"><institution>Department of Biomedical Sciences, Seoul National University Graduate School</institution>, Seoul,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Noh, D Y" sort="Noh, D Y" uniqKey="Noh D" first="D-Y" last="Noh">D-Y Noh</name><affiliation><nlm:aff id="aff29"><institution>Department of Surgery, Seoul National University College of Medicine</institution>, Seoul,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Hopper, J L" sort="Hopper, J L" uniqKey="Hopper J" first="J L" last="Hopper">J L Hopper</name><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Schmidt, D F" sort="Schmidt, D F" uniqKey="Schmidt D" first="D F" last="Schmidt">D F Schmidt</name><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Makalic, E" sort="Makalic, E" uniqKey="Makalic E" first="E" last="Makalic">E. Makalic</name><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Southey, M C" sort="Southey, M C" uniqKey="Southey M" first="M C" last="Southey">M C Southey</name><affiliation><nlm:aff id="aff31"><institution>Department of Pathology, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Teo, S H" sort="Teo, S H" uniqKey="Teo S" first="S H" last="Teo">S H Teo</name><affiliation><nlm:aff id="aff32"><institution>Cancer Research Initiatives Foundation, Sime Darby Medical Centre</institution>, Subang Jaya,<country>Malaysia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff33"><institution>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre</institution>, Kuala Lumpur,<country>Malaysia</country></nlm:aff></affiliation></author><author><name sortKey="Yip, C H" sort="Yip, C H" uniqKey="Yip C" first="C H" last="Yip">C H Yip</name><affiliation><nlm:aff id="aff33"><institution>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre</institution>, Kuala Lumpur,<country>Malaysia</country></nlm:aff></affiliation></author><author><name sortKey="Sivanandan, K" sort="Sivanandan, K" uniqKey="Sivanandan K" first="K" last="Sivanandan">K. Sivanandan</name><affiliation><nlm:aff id="aff32"><institution>Cancer Research Initiatives Foundation, Sime Darby Medical Centre</institution>, Subang Jaya,<country>Malaysia</country></nlm:aff></affiliation></author><author><name sortKey="Tay, W T" sort="Tay, W T" uniqKey="Tay W" first="W-T" last="Tay">W-T Tay</name><affiliation><nlm:aff id="aff34"><institution>Singapore Eye Research Institute, National University of Singapore</institution>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Brauch, H" sort="Brauch, H" uniqKey="Brauch H" first="H" last="Brauch">H. Brauch</name><affiliation><nlm:aff id="aff35"><institution>Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology</institution>, Stuttgart,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff36"><institution>University of Tübingen</institution>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Bruning, T" sort="Bruning, T" uniqKey="Bruning T" first="T" last="Brüning">T. Brüning</name><affiliation><nlm:aff id="aff37"><institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA)</institution>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Hamann, U" sort="Hamann, U" uniqKey="Hamann U" first="U" last="Hamann">U. Hamann</name><affiliation><nlm:aff id="aff38"><institution>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg</institution>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dunning, A M" sort="Dunning, A M" uniqKey="Dunning A" first="A M" last="Dunning">A M Dunning</name><affiliation><nlm:aff id="aff42"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Shah, M" sort="Shah, M" uniqKey="Shah M" first="M" last="Shah">M. Shah</name><affiliation><nlm:aff id="aff42"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Andrulis, I L" sort="Andrulis, I L" uniqKey="Andrulis I" first="I L" last="Andrulis">I L Andrulis</name><affiliation><nlm:aff id="aff43"><institution>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff44"><institution>Department of Molecular Genetics, University of Toronto</institution>, Toronto, Ontario,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Knight, J A" sort="Knight, J A" uniqKey="Knight J" first="J A" last="Knight">J A Knight</name><affiliation><nlm:aff id="aff43"><institution>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff45"><institution>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto</institution>, Toronto, Ontario,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Glendon, G" sort="Glendon, G" uniqKey="Glendon G" first="G" last="Glendon">G. Glendon</name><affiliation><nlm:aff id="aff46"><institution>Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute</institution>, Toronto, Ontario,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Tchatchou, S" sort="Tchatchou, S" uniqKey="Tchatchou S" first="S" last="Tchatchou">S. Tchatchou</name><affiliation><nlm:aff id="aff43"><institution>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Schmidt, M K" sort="Schmidt, M K" uniqKey="Schmidt M" first="M K" last="Schmidt">M K Schmidt</name><affiliation><nlm:aff id="aff47"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Broeks, A" sort="Broeks, A" uniqKey="Broeks A" first="A" last="Broeks">A. Broeks</name><affiliation><nlm:aff id="aff47"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Rosenberg, E H" sort="Rosenberg, E H" uniqKey="Rosenberg E" first="E H" last="Rosenberg">E H Rosenberg</name><affiliation><nlm:aff id="aff47"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van T Veer, L J" sort="Van T Veer, L J" uniqKey="Van T Veer L" first="L J" last="Van'T Veer">L J Van'T Veer</name><affiliation><nlm:aff id="aff47"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Fasching, P A" sort="Fasching, P A" uniqKey="Fasching P" first="P A" last="Fasching">P A Fasching</name><affiliation><nlm:aff id="aff48"><institution>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, Erlangen,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff49"><institution>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles</institution>, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Renner, S P" sort="Renner, S P" uniqKey="Renner S" first="S P" last="Renner">S P Renner</name><affiliation><nlm:aff id="aff48"><institution>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, Erlangen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ekici, A B" sort="Ekici, A B" uniqKey="Ekici A" first="A B" last="Ekici">A B Ekici</name><affiliation><nlm:aff id="aff50"><institution>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg</institution>, Erlangen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Beckmann, M W" sort="Beckmann, M W" uniqKey="Beckmann M" first="M W" last="Beckmann">M W Beckmann</name><affiliation><nlm:aff id="aff48"><institution>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, Erlangen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Shen, C Y" sort="Shen, C Y" uniqKey="Shen C" first="C-Y" last="Shen">C-Y Shen</name><affiliation><nlm:aff id="aff51"><institution>Institute of Biomedical Sciences, Academia Sinica</institution>, Taipei,<country>Taiwan</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff52"><institution>College of Public Health, China Medical University</institution>, Taichong,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Hsiung, C N" sort="Hsiung, C N" uniqKey="Hsiung C" first="C-N" last="Hsiung">C-N Hsiung</name><affiliation><nlm:aff id="aff51"><institution>Institute of Biomedical Sciences, Academia Sinica</institution>, Taipei,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Yu, J C" sort="Yu, J C" uniqKey="Yu J" first="J-C" last="Yu">J-C Yu</name><affiliation><nlm:aff id="aff53"><institution>Tri-Service General Hospital</institution>, Taipei,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Hou, M F" sort="Hou, M F" uniqKey="Hou M" first="M-F" last="Hou">M-F Hou</name><affiliation><nlm:aff id="aff54"><institution>Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital</institution>, Kaohsiung,<country>Taiwan</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff55"><institution>Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital</institution>, Kaohsiung,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Blot, W" sort="Blot, W" uniqKey="Blot W" first="W" last="Blot">W. Blot</name><affiliation><nlm:aff id="aff56"><institution>Department of Medicine, Vanderbilt University</institution>, Nashville,<country>TN USA</country></nlm:aff></affiliation></author><author><name sortKey="Cai, Q" sort="Cai, Q" uniqKey="Cai Q" first="Q" last="Cai">Q. Cai</name><affiliation><nlm:aff id="aff56"><institution>Department of Medicine, Vanderbilt University</institution>, Nashville,<country>TN USA</country></nlm:aff></affiliation></author><author><name sortKey="Wu, A H" sort="Wu, A H" uniqKey="Wu A" first="A H" last="Wu">A H Wu</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Tseng, C C" sort="Tseng, C C" uniqKey="Tseng C" first="C-C" last="Tseng">C-C Tseng</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, D" sort="Van Den Berg, D" uniqKey="Van Den Berg D" first="D" last="Van Den Berg">D. Van Den Berg</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Stram, D O" sort="Stram, D O" uniqKey="Stram D" first="D O" last="Stram">D O Stram</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Cox, A" sort="Cox, A" uniqKey="Cox A" first="A" last="Cox">A. Cox</name><affiliation><nlm:aff id="aff58"><institution>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield</institution>, Sheffield,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Brock, I W" sort="Brock, I W" uniqKey="Brock I" first="I W" last="Brock">I W Brock</name><affiliation><nlm:aff id="aff58"><institution>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield</institution>, Sheffield,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Reed, M W R" sort="Reed, M W R" uniqKey="Reed M" first="M W R" last="Reed">M W R. Reed</name><affiliation><nlm:aff id="aff58"><institution>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield</institution>, Sheffield,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Muir, K" sort="Muir, K" uniqKey="Muir K" first="K" last="Muir">K. Muir</name><affiliation><nlm:aff id="aff59"><institution>Institute of Population Health, University of Manchester</institution>, Manchester,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff60"><institution>Division of Health Sciences, Warwick Medical School</institution>, Coventry,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Lophatananon, A" sort="Lophatananon, A" uniqKey="Lophatananon A" first="A" last="Lophatananon">A. Lophatananon</name><affiliation><nlm:aff id="aff60"><institution>Division of Health Sciences, Warwick Medical School</institution>, Coventry,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Stewart Brown, S" sort="Stewart Brown, S" uniqKey="Stewart Brown S" first="S" last="Stewart-Brown">S. Stewart-Brown</name><affiliation><nlm:aff id="aff60"><institution>Division of Health Sciences, Warwick Medical School</institution>, Coventry,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Siriwanarangsan, P" sort="Siriwanarangsan, P" uniqKey="Siriwanarangsan P" first="P" last="Siriwanarangsan">P. Siriwanarangsan</name><affiliation><nlm:aff id="aff61"><institution>Ministry of Public Health</institution>, Bangkok,<country>Thailand</country></nlm:aff></affiliation></author><author><name sortKey="Zheng, W" sort="Zheng, W" uniqKey="Zheng W" first="W" last="Zheng">W. Zheng</name><affiliation><nlm:aff id="aff62"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center</institution>, Nashville, TN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Deming Halverson, S" sort="Deming Halverson, S" uniqKey="Deming Halverson S" first="S" last="Deming-Halverson">S. Deming-Halverson</name><affiliation><nlm:aff id="aff62"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center</institution>, Nashville, TN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Shrubsole, M J" sort="Shrubsole, M J" uniqKey="Shrubsole M" first="M J" last="Shrubsole">M J Shrubsole</name><affiliation><nlm:aff id="aff62"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center</institution>, Nashville, TN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Long, J" sort="Long, J" uniqKey="Long J" first="J" last="Long">J. Long</name><affiliation><nlm:aff id="aff62"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center</institution>, Nashville, TN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Shu, X O" sort="Shu, X O" uniqKey="Shu X" first="X-O" last="Shu">X-O Shu</name><affiliation><nlm:aff id="aff62"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center</institution>, Nashville, TN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lu, W" sort="Lu, W" uniqKey="Lu W" first="W" last="Lu">W. Lu</name><affiliation><nlm:aff id="aff63"><institution>Shanghai Center for Disease Control and Prevention</institution>, Shanghai,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Gao, Y T" sort="Gao, Y T" uniqKey="Gao Y" first="Y-T" last="Gao">Y-T Gao</name><affiliation><nlm:aff id="aff64"><institution>Shanghai Cancer Institute</institution>, Shanghai,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Zhang, B" sort="Zhang, B" uniqKey="Zhang B" first="B" last="Zhang">B. Zhang</name><affiliation><nlm:aff id="aff62"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center</institution>, Nashville, TN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Radice, P" sort="Radice, P" uniqKey="Radice P" first="P" last="Radice">P. Radice</name><affiliation><nlm:aff id="aff65"><institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>, Milan,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Peterlongo, P" sort="Peterlongo, P" uniqKey="Peterlongo P" first="P" last="Peterlongo">P. Peterlongo</name><affiliation><nlm:aff id="aff66"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>, Milan,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Manoukian, S" sort="Manoukian, S" uniqKey="Manoukian S" first="S" last="Manoukian">S. Manoukian</name><affiliation><nlm:aff id="aff67"><institution>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>, Milan,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Mariette, F" sort="Mariette, F" uniqKey="Mariette F" first="F" last="Mariette">F. Mariette</name><affiliation><nlm:aff id="aff66"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>, Milan,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff68"><institution>Cogentech Cancer Genetic Test Laboratory</institution>, Milan,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, S" sort="Sangrajrang, S" uniqKey="Sangrajrang S" first="S" last="Sangrajrang">S. Sangrajrang</name><affiliation><nlm:aff id="aff69"><institution>National Cancer Institute</institution>, Bangkok,<country>Thailand</country></nlm:aff></affiliation></author><author><name sortKey="Mckay, J" sort="Mckay, J" uniqKey="Mckay J" first="J" last="Mckay">J. Mckay</name><affiliation><nlm:aff id="aff70"><institution>Genetic Susceptibility Group, International Agency for Research on Cancer</institution>, Lyon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Couch, F J" sort="Couch, F J" uniqKey="Couch F" first="F J" last="Couch">F J Couch</name><affiliation><nlm:aff id="aff71"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Toland, A E" sort="Toland, A E" uniqKey="Toland A" first="A E" last="Toland">A E Toland</name><affiliation><nlm:aff id="aff72"><institution>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University</institution>, Columbus, OH,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, D" sort="Yannoukakos, D" uniqKey="Yannoukakos D" first="D" last="Yannoukakos">D. Yannoukakos</name><affiliation><nlm:aff id="aff74"><institution>Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos"</institution>, Athens,<country>Greece</country></nlm:aff></affiliation></author><author><name sortKey="Fletcher, O" sort="Fletcher, O" uniqKey="Fletcher O" first="O" last="Fletcher">O. Fletcher</name><affiliation><nlm:aff id="aff75"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Johnson, N" sort="Johnson, N" uniqKey="Johnson N" first="N" last="Johnson">N. Johnson</name><affiliation><nlm:aff id="aff75"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Silva, I Dos Santos" sort="Silva, I Dos Santos" uniqKey="Silva I" first="I Dos Santos" last="Silva">I Dos Santos Silva</name><affiliation><nlm:aff id="aff76"><institution>London School of Hygiene and Tropical Medicine</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Peto, J" sort="Peto, J" uniqKey="Peto J" first="J" last="Peto">J. Peto</name><affiliation><nlm:aff id="aff76"><institution>London School of Hygiene and Tropical Medicine</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Marme, F" sort="Marme, F" uniqKey="Marme F" first="F" last="Marme">F. Marme</name><affiliation><nlm:aff id="aff77"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff78"><institution>National Center for Tumor Diseases, University of Heidelberg</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Burwinkel, B" sort="Burwinkel, B" uniqKey="Burwinkel B" first="B" last="Burwinkel">B. Burwinkel</name><affiliation><nlm:aff id="aff77"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff79"><institution>Molecular Epidemiology Group, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Guenel, P" sort="Guenel, P" uniqKey="Guenel P" first="P" last="Guénel">P. Guénel</name><affiliation><nlm:aff id="aff80"><institution>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer</institution>, Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff81"><institution>University Paris-Sud, UMRS 1018</institution>, Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Truong, T" sort="Truong, T" uniqKey="Truong T" first="T" last="Truong">T. Truong</name><affiliation><nlm:aff id="aff80"><institution>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer</institution>, Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff81"><institution>University Paris-Sud, UMRS 1018</institution>, Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Sanchez, M" sort="Sanchez, M" uniqKey="Sanchez M" first="M" last="Sanchez">M. Sanchez</name><affiliation><nlm:aff id="aff80"><institution>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer</institution>, Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff81"><institution>University Paris-Sud, UMRS 1018</institution>, Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mulot, C" sort="Mulot, C" uniqKey="Mulot C" first="C" last="Mulot">C. Mulot</name><affiliation><nlm:aff id="aff82"><institution>Inserm (National Institute of Health and Medical Research)</institution>, U775 Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff83"><institution>Centre de Ressources Biologiques EPIGENETEC</institution>, Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bojesen, S E" sort="Bojesen, S E" uniqKey="Bojesen S" first="S E" last="Bojesen">S E Bojesen</name><affiliation><nlm:aff id="aff84"><institution>Copenhagen General Population Study, Herlev University Hospital, University of Copenhagen</institution>, Copenhagen,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff85"><institution>Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen</institution>, Copenhagen,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B G" sort="Nordestgaard, B G" uniqKey="Nordestgaard B" first="B G" last="Nordestgaard">B G Nordestgaard</name><affiliation><nlm:aff id="aff84"><institution>Copenhagen General Population Study, Herlev University Hospital, University of Copenhagen</institution>, Copenhagen,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff85"><institution>Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen</institution>, Copenhagen,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Flyer, H" sort="Flyer, H" uniqKey="Flyer H" first="H" last="Flyer">H. Flyer</name><affiliation><nlm:aff id="aff86"><institution>Department of Breast Surgery, Herlev University Hospital, University of Copenhagen</institution>, Copenhagen,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Brenner, H" sort="Brenner, H" uniqKey="Brenner H" first="H" last="Brenner">H. Brenner</name><affiliation><nlm:aff id="aff87"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff88"><institution>German Cancer Consortium (DKTK)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, A K" sort="Dieffenbach, A K" uniqKey="Dieffenbach A" first="A K" last="Dieffenbach">A K Dieffenbach</name><affiliation><nlm:aff id="aff87"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff88"><institution>German Cancer Consortium (DKTK)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Arndt, V" sort="Arndt, V" uniqKey="Arndt V" first="V" last="Arndt">V. Arndt</name><affiliation><nlm:aff id="aff87"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Stegmaier, C" sort="Stegmaier, C" uniqKey="Stegmaier C" first="C" last="Stegmaier">C. Stegmaier</name><affiliation><nlm:aff id="aff89"><institution>Saarland Cancer Registry</institution>, Saarbrücken,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Mannermaa, A" sort="Mannermaa, A" uniqKey="Mannermaa A" first="A" last="Mannermaa">A. Mannermaa</name><affiliation><nlm:aff id="aff90"><institution>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff91"><institution>Biocenter Kuopio, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff92"><institution>Department of Clinical Pathology, Kuopio University Hospital</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Kataja, V" sort="Kataja, V" uniqKey="Kataja V" first="V" last="Kataja">V. Kataja</name><affiliation><nlm:aff id="aff91"><institution>Biocenter Kuopio, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff93"><institution>School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff94"><institution>Cancer Center, Kuopio University Hospital</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Kosma, V M" sort="Kosma, V M" uniqKey="Kosma V" first="V-M" last="Kosma">V-M Kosma</name><affiliation><nlm:aff id="aff90"><institution>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff91"><institution>Biocenter Kuopio, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff92"><institution>Department of Clinical Pathology, Kuopio University Hospital</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Hartikainen, J M" sort="Hartikainen, J M" uniqKey="Hartikainen J" first="J M" last="Hartikainen">J M Hartikainen</name><affiliation><nlm:aff id="aff90"><institution>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff91"><institution>Biocenter Kuopio, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff92"><institution>Department of Clinical Pathology, Kuopio University Hospital</institution>, Kuopio,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Lambrechts, D" sort="Lambrechts, D" uniqKey="Lambrechts D" first="D" last="Lambrechts">D. Lambrechts</name><affiliation><nlm:aff id="aff95"><institution>Vesalius Research Center (VRC), VIB</institution>, Leuven,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Yesilyurt, B T" sort="Yesilyurt, B T" uniqKey="Yesilyurt B" first="B T" last="Yesilyurt">B T Yesilyurt</name><affiliation><nlm:aff id="aff95"><institution>Vesalius Research Center (VRC), VIB</institution>, Leuven,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Floris, G" sort="Floris, G" uniqKey="Floris G" first="G" last="Floris">G. Floris</name><affiliation><nlm:aff id="aff96"><institution>Multidisciplinary Breast Center, University Hospital Gasthuisberg</institution>, Leuven,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Leunen, K" sort="Leunen, K" uniqKey="Leunen K" first="K" last="Leunen">K. Leunen</name><affiliation><nlm:aff id="aff96"><institution>Multidisciplinary Breast Center, University Hospital Gasthuisberg</institution>, Leuven,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Chang Claude, J" sort="Chang Claude, J" uniqKey="Chang Claude J" first="J" last="Chang-Claude">J. Chang-Claude</name><affiliation><nlm:aff id="aff97"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Rudolph, A" sort="Rudolph, A" uniqKey="Rudolph A" first="A" last="Rudolph">A. Rudolph</name><affiliation><nlm:aff id="aff97"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Seibold, P" sort="Seibold, P" uniqKey="Seibold P" first="P" last="Seibold">P. Seibold</name><affiliation><nlm:aff id="aff97"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, D" sort="Flesch Janys, D" uniqKey="Flesch Janys D" first="D" last="Flesch-Janys">D. Flesch-Janys</name><affiliation><nlm:aff id="aff98"><institution>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf</institution>, Hamburg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff99"><institution>Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf</institution>, Hamburg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Wang, X" sort="Wang, X" uniqKey="Wang X" first="X" last="Wang">X. Wang</name><affiliation><nlm:aff id="aff71"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Olson, J E" sort="Olson, J E" uniqKey="Olson J" first="J E" last="Olson">J E Olson</name><affiliation><nlm:aff id="aff100"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Vachon, C" sort="Vachon, C" uniqKey="Vachon C" first="C" last="Vachon">C. Vachon</name><affiliation><nlm:aff id="aff100"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Purrington, K" sort="Purrington, K" uniqKey="Purrington K" first="K" last="Purrington">K. Purrington</name><affiliation><nlm:aff id="aff100"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Giles, G G" sort="Giles, G G" uniqKey="Giles G" first="G G" last="Giles">G G Giles</name><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff101"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Severi, G" sort="Severi, G" uniqKey="Severi G" first="G" last="Severi">G. Severi</name><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff101"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Baglietto, L" sort="Baglietto, L" uniqKey="Baglietto L" first="L" last="Baglietto">L. Baglietto</name><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff101"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Haiman, C A" sort="Haiman, C A" uniqKey="Haiman C" first="C A" last="Haiman">C A Haiman</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Henderson, B E" sort="Henderson, B E" uniqKey="Henderson B" first="B E" last="Henderson">B E Henderson</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Schumacher, F" sort="Schumacher, F" uniqKey="Schumacher F" first="F" last="Schumacher">F. Schumacher</name><affiliation><nlm:aff id="aff57"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Le Marchand, L" sort="Le Marchand, L" uniqKey="Le Marchand L" first="L" last="Le Marchand">L. Le Marchand</name><affiliation><nlm:aff id="aff102"><institution>University of Hawaii Cancer Center</institution>, Honolulu, HI,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Simard, J" sort="Simard, J" uniqKey="Simard J" first="J" last="Simard">J. Simard</name><affiliation><nlm:aff id="aff103"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec Research Center and Laval University</institution>, Quebec,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Dumont, M" sort="Dumont, M" uniqKey="Dumont M" first="M" last="Dumont">M. Dumont</name><affiliation><nlm:aff id="aff103"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec Research Center and Laval University</institution>, Quebec,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Goldberg, M S" sort="Goldberg, M S" uniqKey="Goldberg M" first="M S" last="Goldberg">M S Goldberg</name><affiliation><nlm:aff id="aff104"><institution>Department of Medicine, McGill University, Montreal</institution>, Montreal, Quebec,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff105"><institution>Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital</institution>, Montreal, Quebec,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Labreche, F" sort="Labreche, F" uniqKey="Labreche F" first="F" last="Labrèche">F. Labrèche</name><affiliation><nlm:aff id="aff106"><institution>Département de médecine sociale et préventive, Département de santé environnementale et santé au travail, Université de Montréal</institution>, Montreal, Quebec,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Winqvist, R" sort="Winqvist, R" uniqKey="Winqvist R" first="R" last="Winqvist">R. Winqvist</name><affiliation><nlm:aff id="aff107"><institution>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital</institution>, Oulu,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Pylk S, K" sort="Pylk S, K" uniqKey="Pylk S K" first="K" last="Pylk S">K. Pylk S</name><affiliation><nlm:aff id="aff107"><institution>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital</institution>, Oulu,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, A" sort="Jukkola Vuorinen, A" uniqKey="Jukkola Vuorinen A" first="A" last="Jukkola-Vuorinen">A. Jukkola-Vuorinen</name><affiliation><nlm:aff id="aff108"><institution>Department of Oncology, Oulu University Hospital, University of Oulu</institution>, Oulu,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Grip, M" sort="Grip, M" uniqKey="Grip M" first="M" last="Grip">M. Grip</name><affiliation><nlm:aff id="aff109"><institution>Department of Surgery, Oulu University Hospital, University of Oulu</institution>, Oulu,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Devilee, P" sort="Devilee, P" uniqKey="Devilee P" first="P" last="Devilee">P. Devilee</name><affiliation><nlm:aff id="aff110"><institution>Department of Human Genetics, Leiden University Medical Center</institution>, Leiden,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Tollenaar, R A E M" sort="Tollenaar, R A E M" uniqKey="Tollenaar R" first="R A E M" last="Tollenaar">R A E M. Tollenaar</name><affiliation><nlm:aff id="aff111"><institution>Department of Surgical Oncology, Leiden University Medical Center</institution>, Leiden,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Seynaeve, C" sort="Seynaeve, C" uniqKey="Seynaeve C" first="C" last="Seynaeve">C. Seynaeve</name><affiliation><nlm:aff id="aff112"><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Centre</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, M" sort="Garcia Closas, M" uniqKey="Garcia Closas M" first="M" last="García-Closas">M. García-Closas</name><affiliation><nlm:aff id="aff13"><institution>Division of Breast Cancer Research, The Institute of Cancer Research</institution>, London,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff113"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, MD,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff114"><institution>Division of Genetics and Epidemiology, Institute of Cancer Research and Breakthrough Breast Cancer Research Centre</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Chanock, S J" sort="Chanock, S J" uniqKey="Chanock S" first="S J" last="Chanock">S J Chanock</name><affiliation><nlm:aff id="aff113"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, MD,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lissowska, J" sort="Lissowska, J" uniqKey="Lissowska J" first="J" last="Lissowska">J. Lissowska</name><affiliation><nlm:aff id="aff115"><institution>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>, Warsaw,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Figueroa, J D" sort="Figueroa, J D" uniqKey="Figueroa J" first="J D" last="Figueroa">J D Figueroa</name><affiliation><nlm:aff id="aff113"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, MD,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Czene, K" sort="Czene, K" uniqKey="Czene K" first="K" last="Czene">K. Czene</name><affiliation><nlm:aff id="aff116"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Eriksson, M" sort="Eriksson, M" uniqKey="Eriksson M" first="M" last="Eriksson">M. Eriksson</name><affiliation><nlm:aff id="aff116"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Humphreys, K" sort="Humphreys, K" uniqKey="Humphreys K" first="K" last="Humphreys">K. Humphreys</name><affiliation><nlm:aff id="aff116"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Darabi, H" sort="Darabi, H" uniqKey="Darabi H" first="H" last="Darabi">H. Darabi</name><affiliation><nlm:aff id="aff116"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Hooning, M J" sort="Hooning, M J" uniqKey="Hooning M" first="M J" last="Hooning">M J Hooning</name><affiliation><nlm:aff id="aff112"><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Centre</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Kriege, M" sort="Kriege, M" uniqKey="Kriege M" first="M" last="Kriege">M. Kriege</name><affiliation><nlm:aff id="aff112"><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Centre</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Collee, J M" sort="Collee, J M" uniqKey="Collee J" first="J M" last="Collée">J M Collée</name><affiliation><nlm:aff id="aff117"><institution>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Tilanus Linthorst, M" sort="Tilanus Linthorst, M" uniqKey="Tilanus Linthorst M" first="M" last="Tilanus-Linthorst">M. Tilanus-Linthorst</name><affiliation><nlm:aff id="aff118"><institution>Department of Surgical Oncology, Family Cancer Clinic, Erasmus University Medical Centre</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Li, J" sort="Li, J" uniqKey="Li J" first="J" last="Li">J. Li</name><affiliation><nlm:aff id="aff119"><institution>Human Genetics Division, Genome Institute of Singapore</institution>, Singapore,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Jakubowska, A" sort="Jakubowska, A" uniqKey="Jakubowska A" first="A" last="Jakubowska">A. Jakubowska</name><affiliation><nlm:aff id="aff120"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Lubinski, J" sort="Lubinski, J" uniqKey="Lubinski J" first="J" last="Lubinski">J. Lubinski</name><affiliation><nlm:aff id="aff120"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Jaworska Bieniek, K" sort="Jaworska Bieniek, K" uniqKey="Jaworska Bieniek K" first="K" last="Jaworska-Bieniek">K. Jaworska-Bieniek</name><affiliation><nlm:aff id="aff120"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Durda, K" sort="Durda, K" uniqKey="Durda K" first="K" last="Durda">K. Durda</name><affiliation><nlm:aff id="aff120"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, H" sort="Nevanlinna, H" uniqKey="Nevanlinna H" first="H" last="Nevanlinna">H. Nevanlinna</name><affiliation><nlm:aff id="aff121"><institution>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital</institution>, Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Muranen, T A" sort="Muranen, T A" uniqKey="Muranen T" first="T A" last="Muranen">T A Muranen</name><affiliation><nlm:aff id="aff121"><institution>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital</institution>, Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, K" sort="Aittom Ki, K" uniqKey="Aittom Ki K" first="K" last="Aittom Ki">K. Aittom Ki</name><affiliation><nlm:aff id="aff122"><institution>Department of Clinical Genetics, Helsinki University Central Hospital</institution>, Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Blomqvist, C" sort="Blomqvist, C" uniqKey="Blomqvist C" first="C" last="Blomqvist">C. Blomqvist</name><affiliation><nlm:aff id="aff123"><institution>Department of Oncology, Helsinki University Central Hospital</institution>, Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Bogdanova, N" sort="Bogdanova, N" uniqKey="Bogdanova N" first="N" last="Bogdanova">N. Bogdanova</name><affiliation><nlm:aff id="aff124"><institution>Department of Obstetrics and Gynaecology, Hannover Medical School</institution>, Hannover,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff125"><institution>Department of Radiation Oncology, Hannover Medical School</institution>, Hannover,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dork, T" sort="Dork, T" uniqKey="Dork T" first="T" last="Dörk">T. Dörk</name><affiliation><nlm:aff id="aff124"><institution>Department of Obstetrics and Gynaecology, Hannover Medical School</institution>, Hannover,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Hall, P" sort="Hall, P" uniqKey="Hall P" first="P" last="Hall">P. Hall</name><affiliation><nlm:aff id="aff116"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, G" sort="Chenevix Trench, G" uniqKey="Chenevix Trench G" first="G" last="Chenevix-Trench">G. Chenevix-Trench</name><affiliation><nlm:aff id="aff19"><institution>QIMR Berghofer Institute of Medical Research</institution>, Brisbane, Queensland,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Easton, D F" sort="Easton, D F" uniqKey="Easton D" first="D F" last="Easton">D F Easton</name><affiliation><nlm:aff id="aff3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff42"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Pharoah, P D P" sort="Pharoah, P D P" uniqKey="Pharoah P" first="P D P" last="Pharoah">P D P. Pharoah</name><affiliation><nlm:aff id="aff3"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff42"><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Arias Perez, J I" sort="Arias Perez, J I" uniqKey="Arias Perez J" first="J I" last="Arias-Perez">J I Arias-Perez</name><affiliation><nlm:aff id="aff126"><institution>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco</institution>, Oviedo,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Zamora, P" sort="Zamora, P" uniqKey="Zamora P" first="P" last="Zamora">P. Zamora</name><affiliation><nlm:aff id="aff127"><institution>Servicio de Oncología Médica, Hospital Universitario La Paz</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J" last="Benítez">J. Benítez</name><affiliation><nlm:aff id="aff1"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Milne, R L" sort="Milne, R L" uniqKey="Milne R" first="R L" last="Milne">R L Milne</name><affiliation><nlm:aff id="aff1"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff30"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff101"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne,<country>Australia</country></nlm:aff></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified <italic>FGFR2</italic> as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in <italic>FGFR1, FGFR3, FGFR4</italic> and <italic>FGFRL1</italic> in the Breast Cancer Association Consortium.</p></sec><sec><title>Methods:</title><p>Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.</p></sec><sec><title>Results:</title><p>Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in <italic>FGFR3</italic>; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02–1.09, <italic>P=</italic>0.0020), which is substantially lower than that observed for SNPs in <italic>FGFR2.</italic></p></sec><sec><title>Conclusion:</title><p>Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for <italic>FGFR2</italic>.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ahmed, S" uniqKey="Ahmed S">S Ahmed</name></author><author><name sortKey="Thomas, G" uniqKey="Thomas G">G Thomas</name></author><author><name sortKey="Ghoussaini, M" uniqKey="Ghoussaini M">M Ghoussaini</name></author><author><name sortKey="Healey, Cs" uniqKey="Healey C">CS Healey</name></author><author><name sortKey="Humphreys, Mk" uniqKey="Humphreys M">MK Humphreys</name></author><author><name sortKey="Platte, R" uniqKey="Platte R">R Platte</name></author><author><name sortKey="Morrison, J" uniqKey="Morrison J">J Morrison</name></author><author><name sortKey="Maranian, M" uniqKey="Maranian M">M Maranian</name></author><author><name sortKey="Pooley, Ka" uniqKey="Pooley K">KA Pooley</name></author><author><name sortKey="Luben, R" uniqKey="Luben R">R Luben</name></author><author><name sortKey="Eccles, D" uniqKey="Eccles D">D Eccles</name></author><author><name sortKey="Evans, Dg" uniqKey="Evans D">DG Evans</name></author><author><name sortKey="Fletcher, O" uniqKey="Fletcher O">O Fletcher</name></author><author><name sortKey="Johnson, N" uniqKey="Johnson N">N Johnson</name></author><author><name sortKey="Dos Santos Silva, I" uniqKey="Dos Santos Silva I">I dos Santos Silva</name></author><author><name sortKey="Peto, J" uniqKey="Peto J">J Peto</name></author><author><name sortKey="Stratton, Mr" uniqKey="Stratton M">MR Stratton</name></author><author><name sortKey="Rahman, N" uniqKey="Rahman N">N Rahman</name></author><author><name sortKey="Jacobs, K" uniqKey="Jacobs K">K Jacobs</name></author><author><name sortKey="Prentice, R" uniqKey="Prentice R">R Prentice</name></author><author><name sortKey="Anderson, Gl" uniqKey="Anderson G">GL Anderson</name></author><author><name sortKey="Rajkovic, A" uniqKey="Rajkovic A">A Rajkovic</name></author><author><name sortKey="Curb, Jd" uniqKey="Curb J">JD Curb</name></author><author><name sortKey="Ziegler, Rg" uniqKey="Ziegler R">RG Ziegler</name></author><author><name sortKey="Berg, Cd" uniqKey="Berg C">CD Berg</name></author><author><name sortKey="Buys, Ss" uniqKey="Buys S">SS Buys</name></author><author><name sortKey="Mccarty, Ca" uniqKey="Mccarty C">CA McCarty</name></author><author><name sortKey="Feigelson, Hs" uniqKey="Feigelson H">HS Feigelson</name></author><author><name sortKey="Calle, Ee" uniqKey="Calle E">EE Calle</name></author><author><name sortKey="Thun, Mj" uniqKey="Thun M">MJ Thun</name></author><author><name sortKey="Diver, Wr" uniqKey="Diver W">WR Diver</name></author><author><name sortKey="Bojesen, S" uniqKey="Bojesen S">S Bojesen</name></author><author><name sortKey="Nordestgaard, Bg" uniqKey="Nordestgaard B">BG Nordestgaard</name></author><author><name sortKey="Flyger, H" uniqKey="Flyger H">H Flyger</name></author><author><name sortKey="Dork, T" uniqKey="Dork T">T Dork</name></author><author><name sortKey="Schurmann, P" uniqKey="Schurmann P">P Schurmann</name></author><author><name sortKey="Hillemanns, P" uniqKey="Hillemanns P">P Hillemanns</name></author><author><name sortKey="Karstens, Jh" uniqKey="Karstens J">JH Karstens</name></author><author><name sortKey="Bogdanova, Nv" uniqKey="Bogdanova N">NV Bogdanova</name></author><author><name sortKey="Antonenkova, Nn" uniqKey="Antonenkova N">NN Antonenkova</name></author><author><name sortKey="Zalutsky, Iv" uniqKey="Zalutsky I">IV Zalutsky</name></author><author><name sortKey="Bermisheva, M" uniqKey="Bermisheva M">M Bermisheva</name></author><author><name sortKey="Fedorova, S" uniqKey="Fedorova S">S Fedorova</name></author><author><name sortKey="Khusnutdinova, E" uniqKey="Khusnutdinova E">E Khusnutdinova</name></author><author><name sortKey="Kang, D" uniqKey="Kang D">D Kang</name></author><author><name sortKey="Yoo, Ky" uniqKey="Yoo K">KY Yoo</name></author><author><name sortKey="Noh, Dy" uniqKey="Noh D">DY Noh</name></author><author><name sortKey="Ahn, Sh" uniqKey="Ahn S">SH Ahn</name></author><author><name sortKey="Devilee, P" uniqKey="Devilee P">P Devilee</name></author><author><name sortKey="Van Asperen, Cj" uniqKey="Van Asperen C">CJ van Asperen</name></author><author><name sortKey="Tollenaar, Ra" uniqKey="Tollenaar R">RA Tollenaar</name></author><author><name sortKey="Seynaeve, C" uniqKey="Seynaeve C">C Seynaeve</name></author><author><name sortKey="Garcia Closas, M" uniqKey="Garcia Closas M">M Garcia-Closas</name></author><author><name sortKey="Lissowska, J" 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uniqKey="Fredericksen Z">Z Fredericksen</name></author><author><name sortKey="Giles, Gg" uniqKey="Giles G">GG Giles</name></author><author><name sortKey="Severi, G" uniqKey="Severi G">G Severi</name></author><author><name sortKey="Baglietto, L" uniqKey="Baglietto L">L Baglietto</name></author><author><name sortKey="English, Dr" uniqKey="English D">DR English</name></author><author><name sortKey="Hankinson, Se" uniqKey="Hankinson S">SE Hankinson</name></author><author><name sortKey="Cox, Dg" uniqKey="Cox D">DG Cox</name></author><author><name sortKey="Kraft, P" uniqKey="Kraft P">P Kraft</name></author><author><name sortKey="Vatten, Lj" uniqKey="Vatten L">LJ Vatten</name></author><author><name sortKey="Hveem, K" uniqKey="Hveem K">K Hveem</name></author><author><name sortKey="Kumle, M" uniqKey="Kumle M">M Kumle</name></author><author><name sortKey="Sigurdson, A" uniqKey="Sigurdson A">A Sigurdson</name></author><author><name sortKey="Doody, M" uniqKey="Doody M">M 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contrib-type="author"><name><surname>Benítez</surname><given-names>J</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Milne</surname><given-names>R L</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff30">30</xref><xref ref-type="aff" rid="aff101">101</xref><xref ref-type="corresp" rid="caf1">*</xref></contrib><aff id="aff1"><label>1</label><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></aff><aff id="aff2"><label>2</label><institution>Department of Molecular, Cellular and Developmental Biology, Yale University</institution>, New Haven, CT,<country>USA</country></aff><aff id="aff3"><label>3</label><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></aff><aff id="aff4"><label>4</label><institution>Biostatistics Unit, IMDEA Food Institute</institution>, Madrid,<country>Spain</country></aff><aff id="aff5"><label>5</label><institution>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO)</institution>, Madrid,<country>Spain</country></aff><aff id="aff6"><label>6</label><institution>CRUK Cambridge Institute, University of Cambridge</institution>, Cambridge,<country>UK</country></aff><aff id="aff7"><label>7</label><institution>Hospital Monte Naranco</institution>, Oviedo,<country>Spain</country></aff><aff id="aff8"><label>8</label><institution>Department of Pathology, Hospital Universitario La Paz, IdiPAZ (Hospital La Paz Institute for Health Research) Universidad Autonoma de Madrid</institution>, Madrid,<country>Spain</country></aff><aff id="aff9"><label>9</label><institution>Laboratory of Pathology and Oncology, Research Unit, Hospital Universitario La Paz, IdiPAZ</institution>, Madrid,<country>Spain</country></aff><aff id="aff10"><label>10</label><institution>Department of Molecular Medicine and Surgery, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></aff><aff id="aff11"><label>11</label><institution>Department of Oncology—Pathology, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></aff><aff id="aff12"><label>12</label><institution>Division of Genetics and Epidemiology, The Institute of Cancer Research</institution>, Sutton,<country>UK</country></aff><aff id="aff13"><label>13</label><institution>Division of Breast Cancer Research, The Institute of Cancer Research</institution>, London,<country>UK</country></aff><aff id="aff14"><label>14</label><institution>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research</institution>, London,<country>UK</country></aff><aff id="aff15"><label>15</label><institution>Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences</institution>, Fukuoka,<country>Japan</country></aff><aff id="aff16"><label>16</label><institution>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute</institution>, Nagoya,<country>Japan</country></aff><aff id="aff17"><label>17</label><institution>Department of Breast Oncology, Aichi Cancer Center Hospital</institution>, Nagoya,<country>Japan</country></aff><aff id="aff18"><label>18</label><institution>Peter MacCallum Cancer Centre</institution>, Melbourne, Victoria,<country>Australia</country></aff><aff id="aff19"><label>19</label><institution>QIMR Berghofer Institute of Medical Research</institution>, Brisbane, Queensland,<country>Australia</country></aff><aff id="aff20"><label>20</label><institution>Saw Swee Hock School of Public Health, Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System</institution>, Singapore,<country>Singapore</country></aff><aff id="aff21"><label>21</label><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</institution>, Singapore,<country>Singapore</country></aff><aff id="aff22"><label>22</label><institution>Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System</institution>, Singapore,<country>Singapore</country></aff><aff id="aff23"><label>23</label><institution>Research Oncology, Division of Cancer Studies, Kings College London Guy's Hospital</institution>, London,<country>UK</country></aff><aff id="aff24"><label>24</label><institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>, Oxford,<country>UK</country></aff><aff id="aff25"><label>25</label><institution>Oxford Biomedical Research Centre, University of Oxford</institution>, Oxford,<country>UK</country></aff><aff id="aff26"><label>26</label><institution>School of Medicine, Clinical Science Institute, National University of Ireland</institution>, Galway,<country>UK</country></aff><aff id="aff27"><label>27</label><institution>Department of Preventive Medicine, Seoul National University College of Medicine</institution>, Seoul,<country>Korea</country></aff><aff id="aff28"><label>28</label><institution>Department of Biomedical Sciences, Seoul National University Graduate School</institution>, Seoul,<country>Korea</country></aff><aff id="aff29"><label>29</label><institution>Department of Surgery, Seoul National University College of Medicine</institution>, Seoul,<country>Korea</country></aff><aff id="aff30"><label>30</label><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></aff><aff id="aff31"><label>31</label><institution>Department of Pathology, University of Melbourne</institution>, Melbourne, Victoria,<country>Australia</country></aff><aff id="aff32"><label>32</label><institution>Cancer Research Initiatives Foundation, Sime Darby Medical Centre</institution>, Subang Jaya,<country>Malaysia</country></aff><aff id="aff33"><label>33</label><institution>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre</institution>, Kuala Lumpur,<country>Malaysia</country></aff><aff id="aff34"><label>34</label><institution>Singapore Eye Research Institute, National University of Singapore</institution>,<country>Singapore</country></aff><aff id="aff35"><label>35</label><institution>Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology</institution>, Stuttgart,<country>Germany</country></aff><aff id="aff36"><label>36</label><institution>University of Tübingen</institution>,<country>Germany</country></aff><aff id="aff37"><label>37</label><institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA)</institution>,<country>Germany</country></aff><aff id="aff38"><label>38</label><institution>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg</institution>,<country>Germany</country></aff><aff id="aff39"><label>39</label><institution>Institute for Occupational Medicine and Maritime Medicine, University Medical Center Hamburg-Eppendorf</institution>,<country>Germany</country></aff><aff id="aff40"><label>40</label><institution>Institute of Pathology, Medical Faculty of the University of Bonn</institution>,<country>Germany</country></aff><aff id="aff41"><label>41</label><institution>Department of Internal Medicine, Evangelische Kliniken Bonn GmbH, Johanniter Krankenhaus, Bonn</institution>,<country>Germany</country></aff><aff id="aff42"><label>42</label><institution>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge</institution>, Cambridge,<country>UK</country></aff><aff id="aff43"><label>43</label><institution>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital</institution>, Toronto, Ontario,<country>Canada</country></aff><aff id="aff44"><label>44</label><institution>Department of Molecular Genetics, University of Toronto</institution>, Toronto, Ontario,<country>Canada</country></aff><aff id="aff45"><label>45</label><institution>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto</institution>, Toronto, Ontario,<country>Canada</country></aff><aff id="aff46"><label>46</label><institution>Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute</institution>, Toronto, Ontario,<country>Canada</country></aff><aff id="aff47"><label>47</label><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>, Amsterdam,<country>The Netherlands</country></aff><aff id="aff48"><label>48</label><institution>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>, Erlangen,<country>Germany</country></aff><aff id="aff49"><label>49</label><institution>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles</institution>, CA,<country>USA</country></aff><aff id="aff50"><label>50</label><institution>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg</institution>, Erlangen,<country>Germany</country></aff><aff id="aff51"><label>51</label><institution>Institute of Biomedical Sciences, Academia Sinica</institution>, Taipei,<country>Taiwan</country></aff><aff id="aff52"><label>52</label><institution>College of Public Health, China Medical University</institution>, Taichong,<country>Taiwan</country></aff><aff id="aff53"><label>53</label><institution>Tri-Service General Hospital</institution>, Taipei,<country>Taiwan</country></aff><aff id="aff54"><label>54</label><institution>Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital</institution>, Kaohsiung,<country>Taiwan</country></aff><aff id="aff55"><label>55</label><institution>Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital</institution>, Kaohsiung,<country>Taiwan</country></aff><aff id="aff56"><label>56</label><institution>Department of Medicine, Vanderbilt University</institution>, Nashville,<country>TN USA</country></aff><aff id="aff57"><label>57</label><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>, Los Angeles, CA,<country>USA</country></aff><aff id="aff58"><label>58</label><institution>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield</institution>, Sheffield,<country>UK</country></aff><aff id="aff59"><label>59</label><institution>Institute of Population Health, University of Manchester</institution>, Manchester,<country>UK</country></aff><aff id="aff60"><label>60</label><institution>Division of Health Sciences, Warwick Medical School</institution>, Coventry,<country>UK</country></aff><aff id="aff61"><label>61</label><institution>Ministry of Public Health</institution>, Bangkok,<country>Thailand</country></aff><aff id="aff62"><label>62</label><institution>Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center</institution>, Nashville, TN,<country>USA</country></aff><aff id="aff63"><label>63</label><institution>Shanghai Center for Disease Control and Prevention</institution>, Shanghai,<country>China</country></aff><aff id="aff64"><label>64</label><institution>Shanghai Cancer Institute</institution>, Shanghai,<country>China</country></aff><aff id="aff65"><label>65</label><institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>, Milan,<country>Italy</country></aff><aff id="aff66"><label>66</label><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>, Milan,<country>Italy</country></aff><aff id="aff67"><label>67</label><institution>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>, Milan,<country>Italy</country></aff><aff id="aff68"><label>68</label><institution>Cogentech Cancer Genetic Test Laboratory</institution>, Milan,<country>Italy</country></aff><aff id="aff69"><label>69</label><institution>National Cancer Institute</institution>, Bangkok,<country>Thailand</country></aff><aff id="aff70"><label>70</label><institution>Genetic Susceptibility Group, International Agency for Research on Cancer</institution>, Lyon,<country>France</country></aff><aff id="aff71"><label>71</label><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></aff><aff id="aff72"><label>72</label><institution>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University</institution>, Columbus, OH,<country>USA</country></aff><aff id="aff73"><label>73</label><institution>Mayo Clinic</institution>, Rochester, MN,<country>USA</country></aff><aff id="aff74"><label>74</label><institution>Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos"</institution>, Athens,<country>Greece</country></aff><aff id="aff75"><label>75</label><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>, London,<country>UK</country></aff><aff id="aff76"><label>76</label><institution>London School of Hygiene and Tropical Medicine</institution>, London,<country>UK</country></aff><aff id="aff77"><label>77</label><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>, Heidelberg,<country>Germany</country></aff><aff id="aff78"><label>78</label><institution>National Center for Tumor Diseases, University of Heidelberg</institution>, Heidelberg,<country>Germany</country></aff><aff id="aff79"><label>79</label><institution>Molecular Epidemiology Group, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></aff><aff id="aff80"><label>80</label><institution>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer</institution>, Villejuif,<country>France</country></aff><aff id="aff81"><label>81</label><institution>University Paris-Sud, UMRS 1018</institution>, Villejuif,<country>France</country></aff><aff id="aff82"><label>82</label><institution>Inserm (National Institute of Health and Medical Research)</institution>, U775 Paris,<country>France</country></aff><aff id="aff83"><label>83</label><institution>Centre de Ressources Biologiques EPIGENETEC</institution>, Paris,<country>France</country></aff><aff id="aff84"><label>84</label><institution>Copenhagen General Population Study, Herlev University Hospital, University of Copenhagen</institution>, Copenhagen,<country>Denmark</country></aff><aff id="aff85"><label>85</label><institution>Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen</institution>, Copenhagen,<country>Denmark</country></aff><aff id="aff86"><label>86</label><institution>Department of Breast Surgery, Herlev University Hospital, University of Copenhagen</institution>, Copenhagen,<country>Denmark</country></aff><aff id="aff87"><label>87</label><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></aff><aff id="aff88"><label>88</label><institution>German Cancer Consortium (DKTK)</institution>, Heidelberg,<country>Germany</country></aff><aff id="aff89"><label>89</label><institution>Saarland Cancer Registry</institution>, Saarbrücken,<country>Germany</country></aff><aff id="aff90"><label>90</label><institution>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></aff><aff id="aff91"><label>91</label><institution>Biocenter Kuopio, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></aff><aff id="aff92"><label>92</label><institution>Department of Clinical Pathology, Kuopio University Hospital</institution>, Kuopio,<country>Finland</country></aff><aff id="aff93"><label>93</label><institution>School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland</institution>, Kuopio,<country>Finland</country></aff><aff id="aff94"><label>94</label><institution>Cancer Center, Kuopio University Hospital</institution>, Kuopio,<country>Finland</country></aff><aff id="aff95"><label>95</label><institution>Vesalius Research Center (VRC), VIB</institution>, Leuven,<country>Belgium</country></aff><aff id="aff96"><label>96</label><institution>Multidisciplinary Breast Center, University Hospital Gasthuisberg</institution>, Leuven,<country>Belgium</country></aff><aff id="aff97"><label>97</label><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>, Heidelberg,<country>Germany</country></aff><aff id="aff98"><label>98</label><institution>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf</institution>, Hamburg,<country>Germany</country></aff><aff id="aff99"><label>99</label><institution>Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf</institution>, Hamburg,<country>Germany</country></aff><aff id="aff100"><label>100</label><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></aff><aff id="aff101"><label>101</label><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne,<country>Australia</country></aff><aff id="aff102"><label>102</label><institution>University of Hawaii Cancer Center</institution>, Honolulu, HI,<country>USA</country></aff><aff id="aff103"><label>103</label><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec Research Center and Laval University</institution>, Quebec,<country>Canada</country></aff><aff id="aff104"><label>104</label><institution>Department of Medicine, McGill University, Montreal</institution>, Montreal, Quebec,<country>Canada</country></aff><aff id="aff105"><label>105</label><institution>Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital</institution>, Montreal, Quebec,<country>Canada</country></aff><aff id="aff106"><label>106</label><institution>Département de médecine sociale et préventive, Département de santé environnementale et santé au travail, Université de Montréal</institution>, Montreal, Quebec,<country>Canada</country></aff><aff id="aff107"><label>107</label><institution>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital</institution>, Oulu,<country>Finland</country></aff><aff id="aff108"><label>108</label><institution>Department of Oncology, Oulu University Hospital, University of Oulu</institution>, Oulu,<country>Finland</country></aff><aff id="aff109"><label>109</label><institution>Department of Surgery, Oulu University Hospital, University of Oulu</institution>, Oulu,<country>Finland</country></aff><aff id="aff110"><label>110</label><institution>Department of Human Genetics, Leiden University Medical Center</institution>, Leiden,<country>The Netherlands</country></aff><aff id="aff111"><label>111</label><institution>Department of Surgical Oncology, Leiden University Medical Center</institution>, Leiden,<country>The Netherlands</country></aff><aff id="aff112"><label>112</label><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Centre</institution>, Rotterdam,<country>The Netherlands</country></aff><aff id="aff113"><label>113</label><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>, Rockville, MD,<country>USA</country></aff><aff id="aff114"><label>114</label><institution>Division of Genetics and Epidemiology, Institute of Cancer Research and Breakthrough Breast Cancer Research Centre</institution>, London,<country>UK</country></aff><aff id="aff115"><label>115</label><institution>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>, Warsaw,<country>Poland</country></aff><aff id="aff116"><label>116</label><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></aff><aff id="aff117"><label>117</label><institution>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center</institution>, Rotterdam,<country>The Netherlands</country></aff><aff id="aff118"><label>118</label><institution>Department of Surgical Oncology, Family Cancer Clinic, Erasmus University Medical Centre</institution>, Rotterdam,<country>The Netherlands</country></aff><aff id="aff119"><label>119</label><institution>Human Genetics Division, Genome Institute of Singapore</institution>, Singapore,<country>Singapore</country></aff><aff id="aff120"><label>120</label><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></aff><aff id="aff121"><label>121</label><institution>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital</institution>, Helsinki,<country>Finland</country></aff><aff id="aff122"><label>122</label><institution>Department of Clinical Genetics, Helsinki University Central Hospital</institution>, Helsinki,<country>Finland</country></aff><aff id="aff123"><label>123</label><institution>Department of Oncology, Helsinki University Central Hospital</institution>, Helsinki,<country>Finland</country></aff><aff id="aff124"><label>124</label><institution>Department of Obstetrics and Gynaecology, Hannover Medical School</institution>, Hannover,<country>Germany</country></aff><aff id="aff125"><label>125</label><institution>Department of Radiation Oncology, Hannover Medical School</institution>, Hannover,<country>Germany</country></aff><aff id="aff126"><label>126</label><institution>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco</institution>, Oviedo,<country>Spain</country></aff><aff id="aff127"><label>127</label><institution>Servicio de Oncología Médica, Hospital Universitario La Paz</institution>, Madrid,<country>Spain</country></aff></contrib-group><author-notes><corresp id="caf1"><label>*</label>E-mail: <email>roger.milne@cancervic.org.au</email></corresp></author-notes><pub-date pub-type="ppub"><day>18</day><month>02</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>18</day><month>02</month><year>2014</year></pub-date><volume>110</volume><issue>4</issue><fpage>1088</fpage><lpage>1100</lpage><history><date date-type="received"><day>04</day><month>09</month><year>2013</year></date><date date-type="rev-recd"><day>08</day><month>11</month><year>2013</year></date><date date-type="accepted"><day>15</day><month>11</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2014 Cancer Research UK</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>Cancer Research UK</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0/"><license-p>From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/</license-p></license></permissions><abstract><sec><title>Background:</title><p>Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified <italic>FGFR2</italic> as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in <italic>FGFR1, FGFR3, FGFR4</italic> and <italic>FGFRL1</italic> in the Breast Cancer Association Consortium.</p></sec><sec><title>Methods:</title><p>Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.</p></sec><sec><title>Results:</title><p>Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in <italic>FGFR3</italic>; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02–1.09, <italic>P=</italic>0.0020), which is substantially lower than that observed for SNPs in <italic>FGFR2.</italic></p></sec><sec><title>Conclusion:</title><p>Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for <italic>FGFR2</italic>.</p></sec></abstract><kwd-group><kwd>breast cancer</kwd><kwd>SNP</kwd><kwd>FGF receptors</kwd><kwd>susceptibility</kwd><kwd>disease subtypes</kwd></kwd-group></article-meta></front><body><p>Breast cancer is a complex disease, with multiple genetic and environmental factors involved in its etiology. Rare mutations in the DNA repair genes <italic>BRCA1</italic> and <italic>BRCA2</italic> confer a high lifetime risk of breast cancer (<xref ref-type="bibr" rid="bib2">Antoniou <italic>et al</italic>, 2003</xref>) and are routinely screened for in women with a strong family history of the disease. Studies focused on other DNA repair genes have led to the discovery that rare coding variants in <italic>CHEK2, ATM</italic>, <italic>BRIP1</italic> and <italic>PALB2</italic> (<xref ref-type="bibr" rid="bib34">Swift <italic>et al</italic>, 1987</xref>; <xref ref-type="bibr" rid="bib21">Meijers-Heijboer <italic>et al</italic>, 2002</xref>; <xref ref-type="bibr" rid="bib30">Seal <italic>et al</italic>, 2006</xref>; <xref ref-type="bibr" rid="bib27">Rahman <italic>et al</italic>, 2007</xref>) are associated with moderately increased breast cancer risk. However, few, if any, candidate-gene- or pathway-based association studies have identified convincing associations with breast cancer risk for common genetic variants (<xref ref-type="bibr" rid="bib35">The Breast Cancer Association Consortium, 2006</xref>). In contrast, empirical genome-wide association studies (GWAS) have proven to be a successful approach to identify common variants associated with small increases in risk, with more than 70 identified in this way to date (<xref ref-type="bibr" rid="bib9">Easton <italic>et al</italic>, 2007</xref>; <xref ref-type="bibr" rid="bib19">Hunter <italic>et al</italic>, 2007</xref>; <xref ref-type="bibr" rid="bib32">Stacey <italic>et al</italic>, 2007</xref>, <xref ref-type="bibr" rid="bib33">2008</xref>; <xref ref-type="bibr" rid="bib1">Ahmed <italic>et al</italic>, 2009</xref>; <xref ref-type="bibr" rid="bib36">Thomas <italic>et al</italic>, 2009</xref>; <xref ref-type="bibr" rid="bib39">Zheng <italic>et al</italic>, 2009</xref>; <xref ref-type="bibr" rid="bib3">Antoniou <italic>et al</italic>, 2010</xref>; <xref ref-type="bibr" rid="bib37">Turnbull <italic>et al</italic>, 2010</xref>; <xref ref-type="bibr" rid="bib7">Cai <italic>et al</italic>, 2011</xref>; <xref ref-type="bibr" rid="bib11">Fletcher <italic>et al</italic>, 2011</xref>; <xref ref-type="bibr" rid="bib15">Haiman <italic>et al</italic>, 2011</xref>; <xref ref-type="bibr" rid="bib14">Ghoussaini <italic>et al</italic>, 2012</xref>; <xref ref-type="bibr" rid="bib31">Siddiq <italic>et al</italic>, 2012</xref>; <xref ref-type="bibr" rid="bib6">Bojesen <italic>et al</italic>, 2013</xref>; <xref ref-type="bibr" rid="bib12">Garcia-Closas <italic>et al</italic>, 2013</xref>; <xref ref-type="bibr" rid="bib24">Michailidou <italic>et al</italic>, 2013</xref>). For the great majority of these associations, the causal variant(s), and even the causal gene, are unknown; thus, the identification of novel candidate genetic susceptibility pathways through this approach is not straightforward.</p><p>An intronic variant in the <italic>FGFR2</italic> gene was one of the first single-nucleotide polymorphisms (SNPs) identified by GWAS as tagging a breast cancer susceptibility locus (<xref ref-type="bibr" rid="bib9">Easton <italic>et al</italic>, 2007</xref>; <xref ref-type="bibr" rid="bib19">Hunter <italic>et al</italic>, 2007</xref>). It is now well-established that the minor allele of this SNP is associated with increased risk of breast cancer, particularly estrogen receptor (ER)-positive disease (<xref ref-type="bibr" rid="bib13">Garcia-Closas <italic>et al</italic>, 2008</xref>). Fine-mapping of the region has suggested that at least one causal variant is located in intron 2 of <italic>FGFR2</italic> (<xref ref-type="bibr" rid="bib9">Easton <italic>et al</italic>, 2007</xref>; <xref ref-type="bibr" rid="bib38">Udler <italic>et al</italic>, 2009</xref>), and functional studies have proposed that rs2981578 affects <italic>FGFR2</italic> expression (<xref ref-type="bibr" rid="bib22">Meyer <italic>et al</italic>, 2008</xref>; <xref ref-type="bibr" rid="bib38">Udler <italic>et al</italic>, 2009</xref>; <xref ref-type="bibr" rid="bib18">Huijts <italic>et al</italic>, 2011</xref>). These findings strongly suggest that <italic>FGFR2</italic> is a breast cancer susceptibility gene.</p><p><italic>FGFR2</italic> is a fibroblast growth factor (FGF) receptor gene; the amino-acid sequence of the protein it encodes is highly conserved across all FGF receptors. The other FGF receptor genes and other genes acting downstream of them in the FGF pathway may also be implicated in the development of breast cancer, although associations with disease risk have not been assessed comprehensively by a study with adequate sample size to detect odds ratios (ORs) of the magnitude observed for SNPs in <italic>FGFR2</italic>.</p><p>We hypothesised that common variants in other genes in the FGF pathway, and in the other FGF receptor genes in particular, might also confer increased breast cancer risk. The primary aim of our investigation was to comprehensively assess associations between breast cancer risk and common variation in the FGF receptor genes <italic>FGFR1, FGFR3, FGFR4</italic> and <italic>FGFRL1</italic> by genotyping selected tag-SNPs in the Breast Cancer Association Consortium (BCAC). A secondary objective was to assess common variants in other genes in the FGF pathway based on a two-stage design.</p><sec sec-type="materials|methods"><title>Materials and methods</title><sec><title>Participants</title><p>Study participants were women from 49 studies participating in BCAC: 38 from populations of predominantly European ancestry, 9 of Asian women and 2 of African–American women (<xref rid="tbl1" ref-type="table">Table 1</xref> and <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 1</xref>). The majority were population-based or hospital-based case–control studies, but some studies selected subjects based on age or oversampled for cases with a family history or bilateral disease. Cases and controls from the CNIO-BCS were also studied in a previous assessment of selected genes in the FGF pathway. All study participants gave informed consent and each study was approved by the corresponding local ethics committee.</p></sec><sec><title>Gene and SNP selection</title><p>Ingenuity Pathways Analysis and selected publications (<xref ref-type="bibr" rid="bib10">Eswarakumar <italic>et al</italic>, 2005</xref>; <xref ref-type="bibr" rid="bib26">Presta <italic>et al</italic>, 2005</xref>; <xref ref-type="bibr" rid="bib8">Chen & Forough, 2006</xref>; <xref ref-type="bibr" rid="bib29">Schwertfeger, 2009</xref>) were used to identify genes reported to be involved downstream of the <italic>FGF</italic> genes in the FGF pathway, particularly those related to angiogenesis. A total of 39 genes, including the FGF receptors <italic>FGFR1</italic> (located at 8p11.22)<italic>, FGFR2</italic> (10q26.13)<italic>, FGFR3</italic> (4p16.3)<italic>, FGFR4</italic> (5q35.2) and <italic>FGFRL1</italic> (4p16.3), was selected for tagging. Single-nucleotide polymorphisms with minor allele frequency (MAF) >5% in the coding and non-coding regions, and within 5 kb upstream and 5 kb downstream of each gene, were identified using HapMap CEU genotype data and dbSNP 128 as reference. The minimum number of tag-SNPs were then selected among all identified SNP using Haploview (<xref ref-type="bibr" rid="bib5">Barrett <italic>et al</italic>, 2005</xref>) based on the following criteria: <italic>r</italic><sup>2</sup>>0.8 and Illumina assay score >0.60. A total of 384 SNPs tagging 39 genes was genotyped in the CNIO-BCS, 324 of which were successfully genotyped (<xref ref-type="supplementary-material" rid="sup1">Supplementary Table 2</xref>). The 31 SNPs tagging genes <italic>FGFR1, FGFR3, FGFR4</italic> and <italic>FGFRL1</italic> were all genotyped in BCAC, along with a further 26 of the 324 tag-SNPs. The latter group comprised SNPs selected based on evidence of association with breast cancer under a log-additive model in the Stage 1 CNIO-BCS. Single-nucleotide polymorphisms in <italic>FGFR2</italic> were not considered, as all were included as part of a separate fine-mapping study (<xref ref-type="bibr" rid="bib23">Meyer <italic>et al</italic>, submitted</xref>). Results from Stage 1 are summarised in <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 2</xref>.</p></sec><sec><title>Genotyping</title><p>Genotyping of the 57 SNPs in the BCAC samples was conducted using a custom Illumina Infinium array (iCOGS) in four centers, as part of a multi-consortia collaboration (the Collaborative Oncological Gene–Environment Study, COGS) as described previously (<xref ref-type="bibr" rid="bib24">Michailidou <italic>et al</italic>, 2013</xref>). Genotypes were called using Illumina's proprietary GenCall algorithm.</p><p>For the genotyping of the 384 SNPs in the Stage 1 CNIO-BCS, genomic DNA was isolated from peripheral blood lymphocytes using automatic DNA extraction (MagNA Pure, Roche Diagnostics, Indianapolis, IN, USA) according to the manufacturer's recommended protocols. This DNA was quantified using Picogreen (Invitrogen, Life Technologies, Grand Island, NY, USA) and for each sample a final quantity of 250 ng was extracted and used for GoldenGate genotyping with VeraCode Technology (Illumina Inc., San Diego, CA, USA). Samples were arranged on 25 96-well plates containing one negative control and at least one study sample in duplicate. Three Centre d'Etude du Polymorphisme Humain (CEPH) trios were used as internal intra- and inter-plate duplicates and to check for Mendelian segregation errors. DNA was extracted, quantified, plated and genotyped at the Spanish National Genotyping Centre (CeGen), Madrid, Spain. All genotypes were determined for each SNP and each plate using manual clustering. Single-nucleotide polymorphisms with call rate <90% were excluded, as were samples with no-calls for more than 20% of included SNPs.</p></sec><sec><title>Statistical methods</title><p>For each SNP, we estimated ORs and 95% confidence intervals (CIs) using unconditional logistic regression. For the analysis of BCAC data, we considered per-allele and co-dominant models using common-allele homozygotes as reference and including study and ethnicity-specific principal components as covariates, as previously described (<xref ref-type="bibr" rid="bib24">Michailidou <italic>et al</italic>, 2013</xref>). Departure from the Hardy–Weinberg equilibrium (HWE) was tested for in controls from individual studies using the <italic>genhwi</italic> module in STATA 11.2 (College Station, TX, USA). A study-stratified <italic>χ</italic><sup>2</sup> test (1df) was applied across studies (<xref ref-type="bibr" rid="bib16">Haldane, 1954</xref>; <xref ref-type="bibr" rid="bib28">Robertson & Hill, 1984</xref>). Between-study heterogeneity in ORs was assessed for each of the three broad racial groups using the <italic>metan</italic> command in STATA to meta-analyse study-specific per-allele log-OR estimates and generate <italic>I</italic><sup>2</sup> statistics; values greater than 50% were considered notable (<xref ref-type="bibr" rid="bib17">Higgins & Thompson, 2002</xref>). Odds ratios specific to disease subtypes defined by ER, PR and HER2 status (positive and negative) were estimated separately for each ethnic subgroup using polytomous logistic regression with control status as the reference outcome. Differences in ORs by disease subtypes were assessed using a likelihood ratio test (LRT). All statistical tests were two-sided.</p><p>The effective number of independent SNPs (V<sub>effLi</sub>) was estimated using the method described by <xref ref-type="bibr" rid="bib20">Li & Ji (2005</xref>). This method was applied via the web-interface matSpDlite (<ext-link ext-link-type="uri" xlink:href="http://gump.qimr.edu.au/general/daleN/matSpDlite/">http://gump.qimr.edu.au/general/daleN/matSpDlite/</ext-link>), based on the observed correlations between SNPs (<xref ref-type="bibr" rid="bib25">Nyholt, 2004</xref>). V<sub>effLi</sub> was then used to calculate a Bonferroni-corrected significance threshold (<italic>α</italic>*). Power calculations were carried out using Quanto v1.2.4 (<ext-link ext-link-type="uri" xlink:href="http://hydra.usc.edu/gxe/">http://hydra.usc.edu/gxe/</ext-link>).</p></sec><sec><title>Single-nucleotide polymorphism imputation</title><p>The genotypes of untyped SNPs were imputed based on data from the March 2012 release of the 1000 genomes project using IMPUTE v2.2. These were converted to allele doses using the <italic>impute2mach</italic> function in the <italic>GenABEL</italic> library in R (<xref ref-type="bibr" rid="bib4">Aulchenko <italic>et al</italic>, 2007</xref>) and analysed under a per-allele model. Imputed SNPs with an estimated MAF <5% were excluded, as were SNPs with an imputation <italic>r</italic><sup>2</sup><80%.</p></sec></sec><sec sec-type="results"><title>Results</title><p>All SNPs in the present analysis had overall call rates >95%. Very strong evidence of departure from HWE was observed for rs34869253 for one study (pKarma, <italic>P=</italic>3.3 × 10<sup>−21</sup>), which was excluded from the subsequent analyses of that SNP. After quality control, there were data available for 53 835 cases and 50 156 controls from BCAC, including 89 050 European women (46 450 cases and 42 600 controls), 12 893 Asian (6269 cases and 6624 controls) and 2048 African–American women (1116 cases and 932 controls) (<xref rid="tbl1" ref-type="table">Table 1</xref>).</p><p>Results from the analysis of the 31 tag-SNPs in <italic>FGFR</italic> genes for white Europeans are summarised in <xref rid="tbl2" ref-type="table">Table 2</xref>. No strong evidence of association was observed, although one SNP (rs743682) in <italic>FGFR3</italic> (MAF=9%) was marginally significant after correction for multiple testing based on a V<sub>effLi</sub> of 23 (per-allele OR=1.05, 95%CI=1.02–1.09, <italic>P=</italic>0.0020, <italic>α</italic>*=0.0022). All SNPs with an associated <italic>P</italic>-value <0.05 were intronic, with the exception of rs1966265, which is a missense variant in <italic>FGFR4</italic>. However, PolyPhen (<ext-link ext-link-type="uri" xlink:href="http://genetics.bwh.harvard.edu/pph2/">http://genetics.bwh.harvard.edu/pph2/</ext-link>) predicts this amino acid change to be benign, with a score of 0.000. On the basis of ENCODE data, no SNP with an associated <italic>P</italic>-value <0.05 was located in a region involved or predicted to be involved in epigenetic regulation, nor at, or within 2 kb of, a CpG island. For European women, we did not observe any evidence of between-study heterogeneity for any SNPs (<italic>I</italic><sup>2</sup>⩽19% <italic>P⩾</italic>0.15) and little evidence of differential associations by disease subtypes defined by ER (<italic>P⩾</italic>0.036), PR (<italic>P⩾</italic>0.084) or HER2 status (<italic>P⩾</italic>0.019).</p><p>We similarly observed little evidence of association with overall breast cancer risk in Asian and African–American women (<xref ref-type="supplementary-material" rid="sup1">Supplementary Tables 3 and 4</xref>, respectively). Nevertheless, a consistent result was observed for Europeans and Asians for rs1966265 in <italic>FGFR4</italic>. The estimated OR per risk (G) allele was 1.03 (95%CI=1.01–1.05; <italic>P=</italic>0.0060) for European women and 1.08 (95%CI=1.03–1.14; <italic>P=</italic>0.0036) for Asian women. There was no evidence of heterogeneity by race for any of the 31 SNPs in FGF receptors (<italic>I</italic><sup>2</sup>=18% <italic>P=</italic>0.14).</p><p>The SNPs genotyped were estimated to capture a variable proportion of the common variation in the four genes considered, as described in the 1000 genomes project; at <italic>r</italic><sup>2</sup>⩾0.80, this coverage was 75% for <italic>FGFR1</italic>, 77% for <italic>FGFR3</italic>, 66% for <italic>FGFR4</italic> and 17% for <italic>FGFRL1.</italic> This coverage was dramatically improved with the inclusion of imputed common SNPs (with imputation <italic>r</italic><sup>2</sup>>0.80) to 95%, 93%, 97% and 84% for <italic>FGFR1, FGFR3, FGFR4</italic> and <italic>FGFRL1,</italic> respectively. No stronger evidence of association was observed for any imputed SNPs (<xref ref-type="supplementary-material" rid="sup1">Supplementary Tables 5–8</xref>).</p><p>Finally, we observed little evidence of association for any of the 26 SNPs in other genes in the FGF pathway, selected based on results from Stage 1 (<xref ref-type="supplementary-material" rid="sup1">Supplementary Table 9</xref>). The results were consistent across the three ethnic groups considered and for disease subtypes defined by ER, PR and HER2 expression.</p><p>It is noteworthy that strong association signals were observed in the Stage 1 Spanish study for selected tag-SNPs rs10736303 (MAF=0.49; per-allele OR=1.37, 95% CI=1.21–1.55, <italic>P=</italic>2.8 × 10<sup>−7</sup>), and rs2981582 (MAF=0.40; per-allele OR=1.35, 95% CI=1.19–1.53, <italic>P=</italic>8.3 × 10<sup>−7</sup>), both in <italic>FGFR2.</italic></p></sec><sec sec-type="discussion"><title>Discussion</title><p>In this multicentre case–control study, we comprehensively assessed common variation in the FGF receptor genes <italic>FGFR1, FGFR3, FGFR4</italic> and <italic>FGFRL1</italic> in 53 835 cases and 50 156 controls and found little evidence of association with risk of breast cancer. This is the largest study we know of assessing a family of genes via a candidate approach based on the findings from GWAS.</p><p>A non-trivial issue in analyses of this kind is the establishment of a statistical significance threshold that adequately controls the proportion of false-positive findings. As permutation-testing was not feasible due to the sample size and number of dummy variables required to adjust for study, we dealt with the issue of non-independence of multiple tests by estimating that the 31 tag-SNPs represented an effective number of 23 independent variables, and applying a Bonferroni correction accordingly. The association of one SNP (rs743682) in <italic>FGFR3</italic> for European women was found to be statistically significant on this basis. However, the <italic>P</italic>-value threshold applied is somewhat questionable in the context of the total of more than 70 000 SNPs nominated for genotyping by BCAC and the total 210 000 genotyped on the iCOGS array. Thus, the current result is far from genome-wide statistical significance and certainly requires independent replication. In any case, the per-allele ORs for <italic>FGFR3</italic>_rs743682 (1.05, 95% CI=1.02–1.09) and <italic>FGFR4</italic>_rs1966265 (1.03, 95% CI=1.01–1.05) appear to be substantially lower than that for rs2981582 in <italic>FGFR2</italic> (1.26, 95% CI=1.23–1.30) (<xref ref-type="bibr" rid="bib9">Easton <italic>et al</italic>, 2007</xref>).</p><p>We estimated that for common SNPs (MAF >0.05) associated with overall breast cancer risk in European women, we had greater than 99% power to detect at genome-wide statistical significance (<italic>P<</italic>5 × 10<sup>−8</sup>) a per-allele OR as low as 1.23 (the lower 95% confidence limit for the OR for <italic>FGFR2</italic>_rs2981582). For a per-allele OR as low as 1.05 and for SNPs with MAF of 0.10, 0.20 and 0.30, the estimated power was 1%, 10% and 24%, respectively. That is, our study provides strong evidence that common variation in <italic>FGFR1, FGFR3, FGFR4</italic> and <italic>FGFRL1</italic> are not associated with breast cancer risk to the degree observed for SNPs in <italic>FGFR2</italic>, although associations of smaller magnitude may exist.</p><p>The hypothesis underlying our study was based on the identification of a functional SNP in intron 2 of <italic>FGFR2</italic> associated with breast cancer susceptibility (<xref ref-type="bibr" rid="bib9">Easton <italic>et al</italic>, 2007</xref>; <xref ref-type="bibr" rid="bib22">Meyer <italic>et al</italic>, 2008</xref>; <xref ref-type="bibr" rid="bib38">Udler <italic>et al</italic>, 2009</xref>; <xref ref-type="bibr" rid="bib18">Huijts <italic>et al</italic>, 2011</xref>). A recent study has subsequently identified three independent risk signals within <italic>FGFR2</italic>, and uncovered likely causal variants and functional mechanisms behind them (<xref ref-type="bibr" rid="bib23">Meyer <italic>et al</italic>, 2013</xref>). Although an association between these SNPs and expression of FGFR2 has not been established, these results provide strong evidence that <italic>FGFR2</italic> is the target gene, and it therefore seems plausible that other FGF receptors or genes acting in the FGF pathway might also be implicated in breast cancer risk. However, we find little evidence that this is the case for the receptors, at least not to the extent observed for common variants in <italic>FGFR2</italic>. Admittedly, the degree to which common variation in the FGF receptor genes was tagged by the genotyped SNPs was good for <italic>FGFR1, FGFR3</italic> and <italic>FGFR4</italic> and poor for <italic>FGFRL1</italic>, but substantial improvement was afforded by imputation. Nevertheless, it is possible that common variation not captured by the genotyped or imputed SNPs may be associated with breast cancer risk. It is also possible that these genes may be implicated in disease susceptibility via regulatory mechanisms involving variants outside the chromosomal boundaries defined for each gene considered. That said, few studies have assessed common variation in candidate genes to this extent, in terms of both gene coverage and sample size.</p><p>The power of our study was much lower for Asian and African–American women; however, our primary focus on European women is consistent with our hypothesis, based on the previous finding in <italic>FGFR2</italic> in this population. Our study was also limited by the power and gene coverage of the stage 1 component which assessed tag-SNPs in the selected genes of the FGF pathway. Therefore, no conclusions can be drawn about the potential implication of common variation in these genes in breast cancer susceptibility. Nevertheless, we checked the chromosomal locations of the 76 established risk-associated loci (<ext-link ext-link-type="uri" xlink:href="http://www.nature.com/icogs/primer/shared-susceptibility-loci-for-breast-prostate-and-ovarian-cancers/">http://www.nature.com/icogs/primer/shared-susceptibility-loci-for-breast-prostate-and-ovarian-cancers/</ext-link>) and found that none were located within 10 kb of any of the 39 genes considered, with the exception of the <italic>FGFR2</italic> locus.</p><p>In conclusion, in this, possibly the largest candidate-gene association study carried out to date, we have observed little evidence of association between common variation in the <italic>FGFR1, FGFR3, FGFR4</italic> and <italic>FGFRL1</italic> genes and risk of breast cancer. Our results suggest that common variants in these FGF receptors are not associated with risk of breast cancer to the degree observed for <italic>FGFR2</italic>.</p></sec></body><back><ack><p>We thank all the individuals who took part in these studies and all the researchers, study staff, clinicians and other health-care providers, technicians and administrative staff who have enabled this work to be carried out. In particular, we thank: Andrew Berchuck (OCAC), Rosalind A Eeles, Ali Amin Al Olama, Zsofia Kote-Jarai, Sara Benlloch (PRACTICAL), Antonis Antoniou, Lesley McGuffog, Ken Offit (CIMBA), Andrew Lee, and Ed Dicks, Craig Luccarini and the staff of the Centre for Genetic Epidemiology Laboratory, Daniel C Tessier, Francois Bacot, Daniel Vincent, Sylvie LaBoissière, Frederic Robidoux and the staff of the McGill University and Génome Québec Innovation Centre, Sune F Nielsen, and the staff of the Copenhagen DNA laboratory, Julie M Cunningham, Sharon A Windebank, Christopher A Hilker, Jeffrey Meyer and the staff of Mayo Clinic Genotyping Core Facility, Maggie Angelakos, Judi Maskiell, Sten Cornelissen, Ellen van der Schoot, Emiel Rutgers, Senno Verhoef, Frans Hogervorst, the Thai Ministry of Public Health (MOPH), Dr Prat Boonyawongviroj (former Permanent Secretary of MOPH), Dr Pornthep Siriwanarungsan (Department Director-General of Disease Control), Alexander Hein, Michael Schrauder, Matthias Rübner, Sonja Oeser, Silke Landrith, Eileen Williams, Elaine Ryder-Mills, Kara Sargus, Niall McInerney, Gabrielle Colleran, Andrew Rowan, Angela Jones, Christ of Sohn, Andeas Schneeweiß, Peter Bugert, the Danish Breast Cancer Group, Ana Osorio, Alicia Barroso, Victoria Fernández, Maika González-Neira, Núria Malats, Francisco Real, Belén Herráez, Núria Álvarez, Esther Díaz, María Miguel-Martin, the CTS Steering Committee (including: Leslie Bernstein, James Lacey, Sophia Wang, Huiyan Ma, Yani Lu and Jessica Clague DeHart at the Beckman Research Institute of the City of Hope; Dennis Deapen, Rich Pinder, Eunjung Lee and Fred Schumacher at the University of Southern California; Pam Horn-Ross, Peggy Reynolds and David Nelson at the Cancer Prevention Institute of California; and Hannah Park at the University of California Irvine), Hartwig Ziegler, Sonja Wolf, Volker Hermann, The GENICA network (Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Germany; (HB, Wing-Yee Lo, Christina Justenhoven), Department of Internal Medicine, Evangelische Kliniken Bonn GmbH, Johanniter Krankenhaus, Bonn, Germany (Yon-Dschun Ko, Christian Baisch), Institute of Pathology, University of Bonn, Germany (Hans-Peter Fischer), Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Germany (UH), Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Germany (TB, Beate Pesch, Sylvia Rabstein, Anne Lotz), Institute of Occupational Medicine and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Germany (Volker Harth)), Tuomas Heikkinen, Irja Erkkilä, Kirsimari Aaltonen, Karl von Smitten, Natalia Antonenkova, Peter Hillemanns, Hans Christiansen, Eija Myöhänen, Helena Kemiläinen, Heather Thorne, Eveline Niedermayr, the AOCS Management Group (D Bowtell, G Chenevix-Trench, A deFazio, D Gertig, A Green, P Webb), the ACS Management Group (A Green, P Parsons, N Hayward, P Webb and D Whiteman), the LAABC data collection team, especially Annie Fung and June Yashiki, Gilian Peuteman, Dominiek Smeets, Thomas Van Brussel, Kathleen Corthouts, Nadia Obi, Judith Heinz, Sabine Behrens, Ursula Eilber, Muhabbet Celik, Til Olchers, Bernad Peissel, Giulietta Scuvera, Daniela Zaffaroni, Bernardo Bonanni, Monica Barile, Irene Feroce, the personnel of the Cogentech Cancer Genetic Test Laboratory, The Mayo Clinic Breast Cancer Patient Registry, Martine Tranchant, Marie-France Valois, Annie Turgeon, Lea Heguy, Phuah Sze Yee, Peter Kang, Kang In Nee, Shivaani Mariapun, Yoon Sook-Yee, Daphne Lee, Teh Yew Ching, Nur Aishah Mohd Taib, Meeri Otsukka, Kari Mononen, Teresa Selander, Nayana Weerasooriya, OFBCR staff, E Krol-Warmerdam, J Molenaar, J Blom, Louise Brinton, Neonila Szeszenia-Dabrowska, Beata Peplonska, Witold Zatonski, Pei Chao, Michael Stagner, Petra Bos, Jannet Blom, Ellen Crepin, Anja Nieuwlaat, Annette Heemskerk, the Erasmus MC Family Cancer Clinic, Sue Higham, Simon Cross, Helen Cramp, Dan Connley, The Eastern Cancer Registration and Information Centre, the SEARCH and EPIC teams, Craig Luccarini, Don Conroy, Caroline Baynes, Kimberley Chua, the Ohio State University Human Genetics Sample Bank and Robert Pilarski. Data on SCCS cancer cases used in this publication were provided by the: Alabama Statewide Cancer Registry; Kentucky Cancer Registry, Lexington, KY; Tennessee Department of Health, Office of Cancer Surveillance; Florida Cancer Data System; North Carolina Central Cancer Registry, North Carolina Division of Public Health; Georgia Comprehensive Cancer Registry; Louisiana Tumor Registry; Mississippi Cancer Registry; South Carolina Central Cancer Registry; Virginia Department of Health, Virginia Cancer Registry; Arkansas Department of Health, Cancer Registry. BCAC is funded by Cancer Research UK (C1287/A10118, C1287/A12014) and by the European Community's Seventh Framework Programme under grant agreement number 223175 (HEALTH-F2-2009-223175) (COGS). Meetings of the BCAC have been funded by the European Union COST programme (BM0606). Genotyping of the iCOGS array was funded by the European Union (HEALTH-F2-2009-223175), Cancer Research UK (C1287/A10710), the Canadian Institutes of Health Research for the ‘CIHR Team in Familial Risks of Breast Cancer' programme, and the Ministry of Economic Development, Innovation and Export Trade of Quebec (PSR-SIIRI-701). Additional support for the iCOGS infrastructure was provided by the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The ABCFS and OFBCR work was supported by grant UM1 CA164920 from the National Cancer Institute (USA). The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the Breast Cancer Family Registry (BCFR) nor does mention of trade names, commercial products or organizations imply endorsement by the US Government or the BCFR. The ABCFS was also supported by the National Health and Medical Research Council of Australia, the New South Wales Cancer Council, the Victorian Health Promotion Foundation (Australia) and the Victorian Breast Cancer Research Consortium. JLH is a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellow and MCS is a NHMRC Senior Research Fellow. The OFBCR work was also supported by the Canadian Institutes of Health Research ‘CIHR Team in Familial Risks of Breast Cancer' program. The ABCS was funded by the Dutch Cancer Society Grant no. NKI2007-3839 and NKI2009-4363. The ACP study is funded by the Breast Cancer Research Trust, UK. The work of the BBCC was partly funded by ELAN-Programme of the University Hospital of Erlangen. The BBCS is funded by Cancer Research UK and Breakthrough Breast Cancer and acknowledges NHS funding to the NIHR Biomedical Research Centre and the National Cancer Research Network (NCRN). ES is supported by NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust in partnership with King's College London, United Kingdom. IT is supported by the Oxford Biomedical Research Centre. The BSUCH study was supported by the Dietmar-Hopp Foundation, the Helmholtz Society and the German Cancer Research Center (DKFZ). The CECILE study was funded by the Fondation de France, the French National Institute of Cancer (INCa), The National League against Cancer, the National Agency for Environmental and Occupational Health and Food Safety (ANSES), the National Agency for Research (ANR) and the Association for Research against Cancer (ARC). The CGPS was supported by the Chief Physician Johan Boserup and Lise Boserup Fund, the Danish Medical Research Council and Herlev Hospital. The CNIO-BCS was supported by the Genome Spain Foundation, the Red Temática de Investigación Cooperativa en Cáncer and grants from the Asociación Española Contra el Cáncer and the Fondo de Investigación Sanitario (PI11/00923 and PI081120). The Human Genotyping-CEGEN Unit, CNIO is supported by the Instituto de Salud Carlos III. DA was supported by a Fellowship from the Michael Manzella Foundation (MMF) and was a participant in the CNIO Summer Training Program. The CTS was initially supported by the California Breast Cancer Act of 1993 and the California Breast Cancer Research Fund (contract 97-10500) and is currently funded through the National Institutes of Health (R01 CA77398). Collection of cancer incidence data was supported by the California Department of Public Health as part of the statewide cancer reporting program mandated by California Health and Safety Code Section 103885. HAC receives support from the Lon V Smith Foundation (LVS39420). The ESTHER study was supported by a grant from the Baden Württemberg Ministry of Science, Research and Arts. Additional cases were recruited in the context of the VERDI study, which was supported by a grant from the German Cancer Aid (Deutsche Krebshilfe). The GENICA was funded by the Federal Ministry of Education and Research (BMBF) Germany grants 01KW9975/5, 01KW9976/8, 01KW9977/0 and 01KW0114, the Robert Bosch Foundation, Stuttgart, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA) as well as the Department of Internal Medicine, Evangelische Kliniken Bonn GmbH, Johanniter Krankenhaus Bonn, Germany. The HEBCS was supported by the Helsinki University Central Hospital Research Fund, Academy of Finland (132473), the Finnish Cancer Society, The Nordic Cancer Union and the Sigrid Juselius Foundation. The HERPACC was supported by a Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports, Culture and Technology of Japan, by a Grant-in-Aid for the Third-Term Comprehensive 10-Year Strategy for Cancer Control from Ministry Health, Labour and Welfare of Japan, by a research grant from Takeda Science Foundation, by Health and Labour Sciences Research Grants for Research on Applying Health Technology from Ministry Health, Labour and Welfare of Japan and by National Cancer Center Research and Development Fund. The HMBCS was supported by short-term fellowships from the German Academic Exchange Program (to NB) and the Friends of Hannover Medical School (to NB)—Financial support for KARBAC was provided through the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet, the Stockholm Cancer Foundation and the Swedish Cancer Society. The KBCP was financially supported by the special Government Funding (EVO) of Kuopio University Hospital grants, Cancer Fund of North Savo, the Finnish Cancer Organizations, the Academy of Finland and by the strategic funding of the University of Eastern Finland. kConFab is supported by grants from the National Breast Cancer Foundation, the NHMRC, the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia and the Cancer Foundation of Western Australia. The kConFab Clinical Follow-Up Study was funded by the NHMRC (145684, 288704 and 454508). Financial support for the AOCS was provided by the United States Army Medical Research and Materiel Command (DAMD17-01-1-0729), the Cancer Council of Tasmania and Cancer Foundation of Western Australia and the NHMRC (199600). GCT and PW are supported by the NHMRC. LAABC is supported by grants (1RB-0287, 3PB-0102, 5PB-0018 and 10PB-0098) from the California Breast Cancer Research Program. Incident breast cancer cases were collected by the USC Cancer Surveillance Program (CSP) which is supported under subcontract by the California Department of Health. The CSP is also part of the National Cancer Institute's Division of Cancer Prevention and Control Surveillance, Epidemiology and End Results Program, under contract number N01CN25403. LMBC is supported by the ‘Stichting tegen Kanker' (232-2008 and 196-2010). The MARIE study was supported by the Deutsche Krebshilfe e.V. (70-2892-BR I), the Federal Ministry of Education and Research (BMBF) Germany (01KH0402), the Hamburg Cancer Society and the German Cancer Research Center (DKFZ). MBCSG is supported by grants from the Italian Association for Cancer Research (AIRC) and by funds from the Italian citizens who allocated a 5 out of 1000 share of their tax payment in support of the Fondazione IRCCS Istituto Nazionale dei Tumori, according to Italian laws (INT-Institutional strategic projects “5 × 1000” ). The MCBCS was supported by the NIH grants (CA122340 and CA128978) and a Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201), the Breast Cancer Research Foundation and a generous gift from the David F and Margaret T Grohne Family Foundation and the Ting Tsung and Wei Fong Chao Foundation. MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian NHMRC grants 209057, 251553 and 504711 and by infrastructure provided by Cancer Council Victoria. The MEC was supported by NIH grants CA63464, CA54281, CA098758 and CA132839. The work of MTLGEBCS was supported by the Quebec Breast Cancer Foundation, the Canadian Institutes of Health Research (grant CRN-87521) and the Ministry of Economic Development, Innovation and Export Trade (grant PSR-SIIRI-701). MYBRCA is funded by research grants from the Malaysian Ministry of Science, Technology and Innovation (MOSTI), Malaysian Ministry of Higher Education (UM.C/HlR/MOHE/06) and Cancer Research Initiatives Foundation (CARIF). Additional controls were recruited by the Singapore Eye Research Institute, which was supported by a grant from the Biomedical Research Council (BMRC08/1/35/19/550), Singapore and the National medical Research Council, Singapore (NMRC/CG/SERI/2010). The NBCS was supported by grants from the Norwegian Research council (155218/V40, 175240/S10 to ALBD, FUGE-NFR 181600/V11 to VNK and a Swizz Bridge Award to ALBD). The NBHS was supported by NIH grant R01CA100374. Biological sample preparation was conducted the Survey and Biospecimen Shared Resource, which is supported by P30 CA68485. The OBCS was supported by research grants from the Finnish Cancer Foundation, the Sigrid Juselius Foundation, the Academy of Finland, the University of Oulu, and the Oulu University Hospital. The ORIGO study was supported by the Dutch Cancer Society (RUL 1997-1505) and the Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL CP16). The PBCS was funded by Intramural Research Funds of the National Cancer Institute, Department of Health and Human Services, USA. pKARMA is a combination of the KARMA and LIBRO-1 studies. KARMA was supported by Märit and Hans Rausings Initiative against Breast Cancer. KARMA and LIBRO-1 were supported the Cancer Risk Prediction Center (CRisP; <ext-link ext-link-type="uri" xlink:href="http://www.crispcenter.org">www.crispcenter.org</ext-link>), a Linnaeus Centre (Contract ID 70867902) financed by the Swedish Research Council. The RBCS was funded by the Dutch Cancer Society (DDHK 2004-3124, DDHK 2009-4318). SASBAC was supported by funding from the Agency for Science, Technology and Research of Singapore (A*STAR), the US National Institute of Health (NIH) and the Susan G Komen Breast Cancer Foundation. KC was financed by the Swedish Cancer Society (5128-B07-01PAF). The SBCGS was supported primarily by NIH grants R01CA64277, R01CA148667 and R37CA70867. Biological sample preparation was conducted the Survey and Biospecimen Shared Resource, which is supported by P30 CA68485. The SBCS was supported by Yorkshire Cancer Research S305PA, S299 and S295. Funding for the SCCS was provided by NIH grant R01 CA092447. The Arkansas Central Cancer Registry is fully funded by a grant from National Program of Cancer Registries, Centers for Disease Control and Prevention (CDC). Data on SCCS cancer cases from Mississippi were collected by the Mississippi Cancer Registry which participates in the National Program of Cancer Registries (NPCR) of the Centers for Disease Control and Prevention (CDC). The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the CDC or the Mississippi Cancer Registry. SEARCH is funded by a programme grant from Cancer Research UK (C490/A10124) and supported by the UK National Institute for Health Research Biomedical Research Centre at the University of Cambridge. SGBCC is funded by the National Medical Research Council start-up Grant and Centre Grant (NMRC/CG/NCIS/2010). The recruitment of controls by the Singapore Consortium of Cohort Studies-Multi-ethnic cohort (SCCS-MEC) was funded by the Biomedical Research Council (grant number: 05/1/21/19/425). SKKDKFZS is supported by the DKFZ. Katarzyna Jaworska is a fellow of International PhD program, Postgraduate School of Molecular Medicine, Warsaw Medical University, supported by the Polish Foundation of Science. The TNBCC was supported by the NIH grant (CA128978), the Breast Cancer Research Foundation, Komen Foundation for the Cure, the Ohio State University Comprehensive Cancer Center, the Stefanie Spielman fund for Breast Cancer Research and a generous gift from the David F and Margaret T Grohne Family Foundation and the Ting Tsung and Wei Fong Chao Foundation. Part of the TNBCC (DEMOKRITOS) has been co-financed by the European Union (European Social Fund–ESF) and Greek national funds through the Operational Program ‘Education and Lifelong Learning' of the National Strategic Reference Framework (NSRF)—Research Funding Program of the General Secretariat for Research & Technology: ARISTEIA. The TWBCS is supported by the Institute of Biomedical Sciences, Academia Sinica and the National Science Council, Taiwan. The UKBGS is funded by Breakthrough Breast Cancer and the Institute of Cancer Research (ICR). ICR acknowledges NHS funding to the NIHR Biomedical Research Centre.</p> </ack><fn-group><fn><p><xref ref-type="supplementary-material" rid="sup1">Supplementary Information</xref> accompanies this paper on British Journal of Cancer website (http://www.nature.com/bjc)</p></fn><fn><p>This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.</p></fn></fn-group><notes><p>The authors declare no conflict of interest.</p></notes><ref-list><ref id="bib1"><mixed-citation publication-type="journal"><person-group 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association study identifies a new breast cancer susceptibility locus at 6q25.1</article-title><source>Nat Genet</source><volume>41</volume><fpage>324</fpage><lpage>328</lpage><pub-id pub-id-type="pmid">19219042</pub-id></mixed-citation></ref></ref-list><sec sec-type="supplementary-material" id="sup1"><title>Supplementary Material</title></sec></back><floats-group><table-wrap id="tbl1"><label>Table 1</label><caption><title>Number of cases and controls included, by study</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="left"></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><bold>Study</bold></th><th align="left" valign="top" charoff="50"><bold>Country</bold></th><th align="center" valign="top" char="." charoff="50"><bold>Controls</bold></th><th align="center" valign="top" char="." charoff="50"><bold>Cases</bold></th><th align="center" valign="top" char="." charoff="50"><bold>ER+</bold></th><th align="center" valign="top" char="." charoff="50"><bold>ER−</bold></th></tr></thead><tbody valign="top"><tr><td colspan="6" align="left" valign="top" charoff="50"><bold>White European women</bold><hr></hr></td></tr><tr><td align="left" valign="top" charoff="50">Australian Breast Cancer Family Study<xref ref-type="fn" rid="t1-fn2">a</xref> (ABCFS)</td><td align="left" valign="top" charoff="50">Australia</td><td align="char" valign="top" char="." charoff="50">551</td><td align="char" valign="top" char="." charoff="50">790</td><td align="char" valign="top" char="." charoff="50">456</td><td align="char" valign="top" char="." charoff="50">261</td></tr><tr><td align="left" valign="top" charoff="50">Amsterdam Breast Cancer Study (ABCS)</td><td align="left" valign="top" charoff="50">Netherlands</td><td align="char" valign="top" char="." charoff="50">1429</td><td align="char" valign="top" char="." charoff="50">1325</td><td align="char" valign="top" char="." charoff="50">420</td><td align="char" valign="top" char="." charoff="50">153</td></tr><tr><td align="left" valign="top" charoff="50">Bavarian Breast Cancer Cases and Controls (BBCC)</td><td align="left" valign="top" charoff="50">Germany</td><td align="char" valign="top" char="." charoff="50">458</td><td align="char" valign="top" char="." charoff="50">564</td><td align="char" valign="top" char="." charoff="50">460</td><td align="char" valign="top" char="." charoff="50">83</td></tr><tr><td align="left" valign="top" charoff="50">British Breast Cancer Study (BBCS)</td><td align="left" valign="top" charoff="50">UK</td><td align="char" valign="top" char="." charoff="50">1397</td><td align="char" valign="top" char="." charoff="50">1554</td><td align="char" valign="top" char="." charoff="50">507</td><td align="char" valign="top" char="." charoff="50">114</td></tr><tr><td align="left" valign="top" charoff="50">Breast Cancer In Galway Genetic Study (BIGGS)</td><td align="left" valign="top" charoff="50">Ireland</td><td align="char" valign="top" char="." charoff="50">719</td><td align="char" valign="top" char="." charoff="50">836</td><td align="char" valign="top" char="." charoff="50">495</td><td align="char" valign="top" char="." charoff="50">154</td></tr><tr><td align="left" valign="top" charoff="50">Breast Cancer Study of the University Clinic Heidelberg (BSUCH)</td><td align="left" valign="top" charoff="50">Germany</td><td align="char" valign="top" char="." charoff="50">954</td><td align="char" valign="top" char="." charoff="50">852</td><td align="char" valign="top" char="." charoff="50">499</td><td align="char" valign="top" char="." charoff="50">154</td></tr><tr><td align="left" valign="top" charoff="50">CECILE Breast Cancer Study (CECILE)</td><td align="left" valign="top" charoff="50">France</td><td align="char" valign="top" char="." charoff="50">999</td><td align="char" valign="top" char="." charoff="50">1019</td><td align="char" valign="top" char="." charoff="50">797</td><td align="char" valign="top" char="." charoff="50">144</td></tr><tr><td align="left" valign="top" charoff="50">Copenhagen General Population Study (CGPS)</td><td align="left" valign="top" charoff="50">Denmark</td><td align="char" valign="top" char="." charoff="50">4086</td><td align="char" valign="top" char="." charoff="50">2901</td><td align="char" valign="top" char="." charoff="50">1919</td><td align="char" valign="top" char="." charoff="50">357</td></tr><tr><td align="left" valign="top" charoff="50">Spanish National Cancer Centre Breast Cancer Study (CNIO-BCS)</td><td align="left" valign="top" charoff="50">Spain</td><td align="char" valign="top" char="." charoff="50">876</td><td align="char" valign="top" char="." charoff="50">902</td><td align="char" valign="top" char="." charoff="50">242</td><td align="char" valign="top" char="." charoff="50">88</td></tr><tr><td align="left" valign="top" charoff="50">California Teachers Study (CTS)</td><td align="left" valign="top" charoff="50">USA</td><td align="char" valign="top" char="." charoff="50">71</td><td align="char" valign="top" char="." charoff="50">68</td><td align="char" valign="top" char="." charoff="50">0</td><td align="char" valign="top" char="." charoff="50">17</td></tr><tr><td align="left" valign="top" charoff="50">ESTHER Breast Cancer Study (ESTHER)</td><td align="left" valign="top" charoff="50">Germany</td><td align="char" valign="top" char="." charoff="50">502</td><td align="char" valign="top" char="." charoff="50">478</td><td align="char" valign="top" char="." charoff="50">304</td><td align="char" valign="top" char="." charoff="50">98</td></tr><tr><td align="left" valign="top" charoff="50">Gene–Environment Interaction and Breast Cancer in Germany (GENICA)</td><td align="left" valign="top" charoff="50">Germany</td><td align="char" valign="top" char="." charoff="50">427</td><td align="char" valign="top" char="." charoff="50">465</td><td align="char" valign="top" char="." charoff="50">328</td><td align="char" valign="top" char="." charoff="50">119</td></tr><tr><td align="left" valign="top" charoff="50">Helsinki Breast Cancer Study (HEBCS)</td><td align="left" valign="top" charoff="50">Finland</td><td align="char" valign="top" char="." charoff="50">1234</td><td align="char" valign="top" char="." charoff="50">1664</td><td align="char" valign="top" char="." charoff="50">1295</td><td align="char" valign="top" char="." charoff="50">237</td></tr><tr><td align="left" valign="top" charoff="50">Hannover-Minsk Breast Cancer Study (HMBCS)</td><td align="left" valign="top" charoff="50">Belarus</td><td align="char" valign="top" char="." charoff="50">130</td><td align="char" valign="top" char="." charoff="50">690</td><td align="char" valign="top" char="." charoff="50">37</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50">Karolinska Breast Cancer Study (KARBAC)</td><td align="left" valign="top" charoff="50">Sweden</td><td align="char" valign="top" char="." charoff="50">662</td><td align="char" valign="top" char="." charoff="50">722</td><td align="char" valign="top" char="." charoff="50">338</td><td align="char" valign="top" char="." charoff="50">63</td></tr><tr><td align="left" valign="top" charoff="50">Kuopio Breast Cancer Project (KBCP)</td><td align="left" valign="top" charoff="50">Finland</td><td align="char" valign="top" char="." charoff="50">251</td><td align="char" valign="top" char="." charoff="50">445</td><td align="char" valign="top" char="." charoff="50">304</td><td align="char" valign="top" char="." charoff="50">97</td></tr><tr><td align="left" valign="top" charoff="50">kConFab/Australian Ovarian Cancer Study (kConFab/AOCS)</td><td align="left" valign="top" charoff="50">Australia</td><td align="char" valign="top" char="." charoff="50">897</td><td align="char" valign="top" char="." charoff="50">613</td><td align="char" valign="top" char="." charoff="50">162</td><td align="char" valign="top" char="." charoff="50">59</td></tr><tr><td align="left" valign="top" charoff="50">Leuven Multidisciplinary Breast Centre (LMBC)</td><td align="left" valign="top" charoff="50">Belgium</td><td align="char" valign="top" char="." charoff="50">1388</td><td align="char" valign="top" char="." charoff="50">2671</td><td align="char" valign="top" char="." charoff="50">2071</td><td align="char" valign="top" char="." charoff="50">379</td></tr><tr><td align="left" valign="top" charoff="50">Mammary Carcinoma Risk Factor Investigation (MARIE)</td><td align="left" valign="top" charoff="50">Germany</td><td align="char" valign="top" char="." charoff="50">1778</td><td align="char" valign="top" char="." charoff="50">1818</td><td align="char" valign="top" char="." charoff="50">1349</td><td align="char" valign="top" char="." charoff="50">399</td></tr><tr><td align="left" valign="top" charoff="50">Milan Breast Cancer Study Group (MBCSG)</td><td align="left" valign="top" charoff="50">Italy</td><td align="char" valign="top" char="." charoff="50">400</td><td align="char" valign="top" char="." charoff="50">488</td><td align="char" valign="top" char="." charoff="50">149</td><td align="char" valign="top" char="." charoff="50">42</td></tr><tr><td align="left" valign="top" charoff="50">Mayo Clinic Breast Cancer Study (MCBCS)</td><td align="left" valign="top" charoff="50">USA</td><td align="char" valign="top" char="." charoff="50">1931</td><td align="char" valign="top" char="." charoff="50">1862</td><td align="char" valign="top" char="." charoff="50">1486</td><td align="char" valign="top" char="." charoff="50">295</td></tr><tr><td align="left" valign="top" charoff="50">Melbourne Collaborative Cohort Study (MCCS)</td><td align="left" valign="top" charoff="50">Australia</td><td align="char" valign="top" char="." charoff="50">511</td><td align="char" valign="top" char="." charoff="50">614</td><td align="char" valign="top" char="." charoff="50">352</td><td align="char" valign="top" char="." charoff="50">119</td></tr><tr><td align="left" valign="top" charoff="50">Multi-ethnic Cohort (MEC)</td><td align="left" valign="top" charoff="50">USA</td><td align="char" valign="top" char="." charoff="50">741</td><td align="char" valign="top" char="." charoff="50">731</td><td align="char" valign="top" char="." charoff="50">415</td><td align="char" valign="top" char="." charoff="50">87</td></tr><tr><td align="left" valign="top" charoff="50">Montreal Gene–Environment Breast Cancer Study (MTLGEBCS)</td><td align="left" valign="top" charoff="50">Canada</td><td align="char" valign="top" char="." charoff="50">436</td><td align="char" valign="top" char="." charoff="50">489</td><td align="char" valign="top" char="." charoff="50">421</td><td align="char" valign="top" char="." charoff="50">64</td></tr><tr><td align="left" valign="top" charoff="50">Norwegian Breast Cancer Study (NBCS)</td><td align="left" valign="top" charoff="50">Norway</td><td align="char" valign="top" char="." charoff="50">70</td><td align="char" valign="top" char="." charoff="50">22</td><td align="char" valign="top" char="." charoff="50">0</td><td align="char" valign="top" char="." charoff="50">22</td></tr><tr><td align="left" valign="top" charoff="50">Oulu Breast Cancer Study (OBCS)</td><td align="left" valign="top" charoff="50">Finland</td><td align="char" valign="top" char="." charoff="50">414</td><td align="char" valign="top" char="." charoff="50">507</td><td align="char" valign="top" char="." charoff="50">407</td><td align="char" valign="top" char="." charoff="50">100</td></tr><tr><td align="left" valign="top" charoff="50">Ontario Familial Breast Cancer Registry<xref ref-type="fn" rid="t1-fn3">b</xref> (OFBCR)</td><td align="left" valign="top" charoff="50">Canada</td><td align="char" valign="top" char="." charoff="50">511</td><td align="char" valign="top" char="." charoff="50">1175</td><td align="char" valign="top" char="." charoff="50">630</td><td align="char" valign="top" char="." charoff="50">268</td></tr><tr><td align="left" valign="top" charoff="50">Leiden University Medical Centre Breast Cancer Study (ORIGO)</td><td align="left" valign="top" charoff="50">Netherlands</td><td align="char" valign="top" char="." charoff="50">327</td><td align="char" valign="top" char="." charoff="50">357</td><td align="char" valign="top" char="." charoff="50">211</td><td align="char" valign="top" char="." charoff="50">70</td></tr><tr><td align="left" valign="top" charoff="50">NCI Polish Breast Cancer Study (PBCS)</td><td align="left" valign="top" charoff="50">Poland</td><td align="char" valign="top" char="." charoff="50">424</td><td align="char" valign="top" char="." charoff="50">519</td><td align="char" valign="top" char="." charoff="50">519</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50">Karolinska Mammography Project for Risk Prediction of Breast Cancer (pKARMA)</td><td align="left" valign="top" charoff="50">Sweden</td><td align="char" valign="top" char="." charoff="50">5537</td><td align="char" valign="top" char="." charoff="50">5434</td><td align="char" valign="top" char="." charoff="50">3672</td><td align="char" valign="top" char="." charoff="50">702</td></tr><tr><td align="left" valign="top" charoff="50">Rotterdam Breast Cancer Study (RBCS)</td><td align="left" valign="top" charoff="50">Netherlands</td><td align="char" valign="top" char="." charoff="50">699</td><td align="char" valign="top" char="." charoff="50">664</td><td align="char" valign="top" char="." charoff="50">368</td><td align="char" valign="top" char="." charoff="50">131</td></tr><tr><td align="left" valign="top" charoff="50">Singapore and Sweden Breast Cancer Study (SASBAC)</td><td align="left" valign="top" charoff="50">Sweden</td><td align="char" valign="top" char="." charoff="50">1378</td><td align="char" valign="top" char="." charoff="50">1163</td><td align="char" valign="top" char="." charoff="50">663</td><td align="char" valign="top" char="." charoff="50">144</td></tr><tr><td align="left" valign="top" charoff="50">Sheffield Breast Cancer Study (SBCS)</td><td align="left" valign="top" charoff="50">UK</td><td align="char" valign="top" char="." charoff="50">848</td><td align="char" valign="top" char="." charoff="50">843</td><td align="char" valign="top" char="." charoff="50">377</td><td align="char" valign="top" char="." charoff="50">105</td></tr><tr><td align="left" valign="top" charoff="50">Studies of Epidemiology and Risk factors in Cancer Heredity (SEARCH)</td><td align="left" valign="top" charoff="50">UK</td><td align="char" valign="top" char="." charoff="50">8069</td><td align="char" valign="top" char="." charoff="50">9347</td><td align="char" valign="top" char="." charoff="50">5160</td><td align="char" valign="top" char="." charoff="50">1181</td></tr><tr><td align="left" valign="top" charoff="50">Städtisches Klinikum Karlsruhe Deutsches Krebsforschungszentrum Study (SKKDKFZS)</td><td align="left" valign="top" charoff="50">Germany</td><td align="char" valign="top" char="." charoff="50">29</td><td align="char" valign="top" char="." charoff="50">136</td><td align="char" valign="top" char="." charoff="50">0</td><td align="char" valign="top" char="." charoff="50">136</td></tr><tr><td align="left" valign="top" charoff="50">IHCC-Szczecin Breast Cancer Study (SZBCS)</td><td align="left" valign="top" charoff="50">Poland</td><td align="char" valign="top" char="." charoff="50">315</td><td align="char" valign="top" char="." charoff="50">365</td><td align="char" valign="top" char="." charoff="50">165</td><td align="char" valign="top" char="." charoff="50">60</td></tr><tr><td align="left" valign="top" charoff="50">Triple Negative Breast Cancer Consortium Study (TNBCC)</td><td align="left" valign="top" charoff="50">Various</td><td align="char" valign="top" char="." charoff="50">542</td><td align="char" valign="top" char="." charoff="50">881</td><td align="char" valign="top" char="." charoff="50">0</td><td align="char" valign="top" char="." charoff="50">881</td></tr><tr><td align="left" valign="top" charoff="50">UK Breakthrough Generations Study (UKBGS)<hr></hr></td><td align="left" valign="top" charoff="50">UK<hr></hr></td><td align="char" valign="top" char="." charoff="50">470<hr></hr></td><td align="char" valign="top" char="." charoff="50">476<hr></hr></td><td align="char" valign="top" char="." charoff="50">96<hr></hr></td><td align="char" valign="top" char="." charoff="50">22<hr></hr></td></tr><tr><td colspan="6" align="left" valign="top" charoff="50"><bold>Asian women</bold><hr></hr></td></tr><tr><td align="left" valign="top" charoff="50">Asian Cancer Project (ACP)</td><td align="left" valign="top" charoff="50">Thailand</td><td align="char" valign="top" char="." charoff="50">636</td><td align="char" valign="top" char="." charoff="50">423</td><td align="char" valign="top" char="." charoff="50">92</td><td align="char" valign="top" char="." charoff="50">53</td></tr><tr><td align="left" valign="top" charoff="50">Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC)</td><td align="left" valign="top" charoff="50">Japan</td><td align="char" valign="top" char="." charoff="50">1376</td><td align="char" valign="top" char="." charoff="50">694</td><td align="char" valign="top" char="." charoff="50">395</td><td align="char" valign="top" char="." charoff="50">139</td></tr><tr><td align="left" valign="top" charoff="50">Los Angeles County Asian-American Breast Cancer Case–Control (LAABC)</td><td align="left" valign="top" charoff="50">USA</td><td align="char" valign="top" char="." charoff="50">990</td><td align="char" valign="top" char="." charoff="50">812</td><td align="char" valign="top" char="." charoff="50">528</td><td align="char" valign="top" char="." charoff="50">138</td></tr><tr><td align="left" valign="top" charoff="50">Malaysian Breast Cancer Genetic Study (MYBRCA)</td><td align="left" valign="top" charoff="50">Malaysia</td><td align="char" valign="top" char="." charoff="50">610</td><td align="char" valign="top" char="." charoff="50">770</td><td align="char" valign="top" char="." charoff="50">422</td><td align="char" valign="top" char="." charoff="50">291</td></tr><tr><td align="left" valign="top" charoff="50">Shanghai Breast Cancer Genetic Study (SBCGS)</td><td align="left" valign="top" charoff="50">China</td><td align="char" valign="top" char="." charoff="50">892</td><td align="char" valign="top" char="." charoff="50">848</td><td align="char" valign="top" char="." charoff="50">510</td><td align="char" valign="top" char="." charoff="50">276</td></tr><tr><td align="left" valign="top" charoff="50">Seoul Breast Cancer Study (SEBCS)</td><td align="left" valign="top" charoff="50">South Korea</td><td align="char" valign="top" char="." charoff="50">1129</td><td align="char" valign="top" char="." charoff="50">1162</td><td align="char" valign="top" char="." charoff="50">657</td><td align="char" valign="top" char="." charoff="50">375</td></tr><tr><td align="left" valign="top" charoff="50">Singapore Breast Cancer Cohort (SGBCC)</td><td align="left" valign="top" charoff="50">Singapore</td><td align="char" valign="top" char="." charoff="50">502</td><td align="char" valign="top" char="." charoff="50">533</td><td align="char" valign="top" char="." charoff="50">272</td><td align="char" valign="top" char="." charoff="50">108</td></tr><tr><td align="left" valign="top" charoff="50">IARC-Thai Breast Cancer (TBCS)</td><td align="left" valign="top" charoff="50">Thailand</td><td align="char" valign="top" char="." charoff="50">253</td><td align="char" valign="top" char="." charoff="50">138</td><td align="char" valign="top" char="." charoff="50">26</td><td align="char" valign="top" char="." charoff="50">26</td></tr><tr><td align="left" valign="top" charoff="50">Taiwanese Breast Cancer Study (TWBCS)<hr></hr></td><td align="left" valign="top" charoff="50">Taiwan<hr></hr></td><td align="char" valign="top" char="." charoff="50">236<hr></hr></td><td align="char" valign="top" char="." charoff="50">889<hr></hr></td><td align="char" valign="top" char="." charoff="50">460<hr></hr></td><td align="char" valign="top" char="." charoff="50">204<hr></hr></td></tr><tr><td colspan="6" align="left" valign="top" charoff="50"><bold>African</bold><hr></hr></td></tr><tr><td align="left" valign="top" charoff="50">Southern Community Cohort Study (SCCS)</td><td align="left" valign="top" charoff="50">USA</td><td align="char" valign="top" char="." charoff="50">680</td><td align="char" valign="top" char="." charoff="50">679</td><td align="char" valign="top" char="." charoff="50">0</td><td align="char" valign="top" char="." charoff="50">0</td></tr><tr><td align="left" valign="top" charoff="50">Nashville Breast Health Study (NBHS)</td><td align="left" valign="top" charoff="50">USA</td><td align="char" valign="top" char="." charoff="50">252</td><td align="char" valign="top" char="." charoff="50">437</td><td align="char" valign="top" char="." charoff="50">199</td><td align="char" valign="top" char="." charoff="50">222</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td><td align="char" valign="top" char="." charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50">Total</td><td align="left" valign="top" charoff="50"> </td><td align="char" valign="top" char="." charoff="50">50156</td><td align="char" valign="top" char="." charoff="50">53835</td><td align="char" valign="top" char="." charoff="50">30635</td><td align="char" valign="top" char="." charoff="50">9120</td></tr></tbody></table><table-wrap-foot><fn id="t1-fn1"><p>Abbreviations: ER−=estrogen receptor-negative cases; ER+=estrogen receptor-positive cases.</p></fn><fn id="t1-fn2"><label>a</label><p>Australian site of the Breast Cancer Family Registry.</p></fn><fn id="t1-fn3"><label>b</label><p>Ontario site of the Breast Cancer Family Registry.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tbl2"><label>Table 2</label><caption><title>Summary results for SNPs in FGF receptor genes for white European women</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="char" char="."></col><col align="char" char="("></col><col align="char" char="("></col><col align="char" char="("></col><col align="char" char="."></col><col align="char" char="("></col><col align="char" char="("></col><col align="char" char="."></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> <hr></hr></th><th align="center" valign="top" charoff="50"> <hr></hr></th><th align="char" valign="top" char="." charoff="50"> <hr></hr></th><th colspan="3" align="center" valign="top" char="(" charoff="50"><bold>OR (95%CI)</bold><hr></hr></th><th align="char" valign="top" char="." charoff="50"> <hr></hr></th><th colspan="2" align="center" valign="top" char="(" charoff="50"><bold>OR (95%CI)</bold><hr></hr></th><th align="char" valign="top" char="." charoff="50"> <hr></hr></th></tr><tr><th align="left" valign="top" charoff="50"><bold>SNP</bold></th><th align="center" valign="top" charoff="50"><bold>Alleles</bold></th><th align="char" valign="top" char="." charoff="50"><bold>MAF</bold></th><th align="center" valign="top" char="(" charoff="50"><bold>Aa</bold></th><th align="center" valign="top" char="(" charoff="50"><bold>aa</bold></th><th align="center" valign="top" char="(" charoff="50"><bold>per-a-allele</bold></th><th align="center" valign="top" char="." charoff="50"><italic><bold>P</bold></italic></th><th align="center" valign="top" char="(" charoff="50"><bold>ER−</bold></th><th align="center" valign="top" char="(" charoff="50"><bold>ER+</bold></th><th align="center" valign="top" char="." charoff="50"><italic><bold>P-het</bold></italic></th></tr></thead><tbody valign="top"><tr><td colspan="10" align="left" valign="top" charoff="50"><bold><italic>FGFR1</italic></bold><hr></hr></td></tr><tr><td align="left" valign="top" charoff="50">rs10958704</td><td align="center" valign="top" charoff="50">A<bold>G</bold></td><td align="char" valign="top" char="." charoff="50">0.40</td><td align="char" valign="top" char="(" charoff="50">0.98 (0.95–1.01)</td><td align="char" valign="top" char="(" charoff="50">0.98 (0.94–1.02)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.97–1.01)</td><td align="char" valign="top" char="." charoff="50">0.18</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.96–1.03)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.97–1.02)</td><td align="char" valign="top" char="." charoff="50">0.91</td></tr><tr><td align="left" valign="top" charoff="50">rs17182141</td><td align="center" valign="top" charoff="50">A<bold>G</bold></td><td align="char" valign="top" char="." charoff="50">0.06</td><td align="char" valign="top" char="(" charoff="50">1.05 (1.00–1.09)</td><td align="char" valign="top" char="(" charoff="50">0.95 (0.75–1.22)</td><td align="char" valign="top" char="(" charoff="50">1.04 (1.00–1.08)</td><td align="char" valign="top" char="." charoff="50">0.057</td><td align="char" valign="top" char="(" charoff="50">1.08 (1.00–1.17)</td><td align="char" valign="top" char="(" charoff="50">1.04 (0.99–1.09)</td><td align="char" valign="top" char="." charoff="50">0.30</td></tr><tr><td align="left" valign="top" charoff="50">rs2288696</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.21</td><td align="char" valign="top" char="(" charoff="50">1.02 (0.99–1.05)</td><td align="char" valign="top" char="(" charoff="50">1.07 (1.00–1.14)</td><td align="char" valign="top" char="(" charoff="50">1.03 (1.00–1.05)</td><td align="char" valign="top" char="." charoff="50">0.023</td><td align="char" valign="top" char="(" charoff="50">1.05 (1.01–1.10)</td><td align="char" valign="top" char="(" charoff="50">1.03 (1.00–1.06)</td><td align="char" valign="top" char="." charoff="50">0.35</td></tr><tr><td align="left" valign="top" charoff="50">rs2411256</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.24</td><td align="char" valign="top" char="(" charoff="50">1.02 (0.99–1.05)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.95–1.07)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.99–1.03)</td><td align="char" valign="top" char="." charoff="50">0.36</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.95–1.04)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.99–1.04)</td><td align="char" valign="top" char="." charoff="50">0.44</td></tr><tr><td align="left" valign="top" charoff="50">rs2978076</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.08</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.96–1.03)</td><td align="char" valign="top" char="(" charoff="50">1.22 (1.04–1.44)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.98–1.05)</td><td align="char" valign="top" char="." charoff="50">0.53</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.92–1.06)</td><td align="char" valign="top" char="(" charoff="50">1.02 (0.98–1.06)</td><td align="char" valign="top" char="." charoff="50">0.37</td></tr><tr><td align="left" valign="top" charoff="50">rs2978083</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.05</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.96–1.03)</td><td align="char" valign="top" char="(" charoff="50">1.22 (1.04–1.44)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.98–1.05)</td><td align="char" valign="top" char="." charoff="50">0.53</td><td align="char" valign="top" char="(" charoff="50">0.97 (0.89–1.06)</td><td align="char" valign="top" char="(" charoff="50">1.03 (0.97–1.08)</td><td align="char" valign="top" char="." charoff="50">0.27</td></tr><tr><td align="left" valign="top" charoff="50">rs3758102</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.26</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.98–1.04)</td><td align="char" valign="top" char="(" charoff="50">1.02 (0.96–1.07)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.99–1.03)</td><td align="char" valign="top" char="." charoff="50">0.35</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.97–1.05)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.98–1.04)</td><td align="char" valign="top" char="." charoff="50">0.95</td></tr><tr><td align="left" valign="top" charoff="50">rs3925</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.23</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.98–1.04)</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.95–1.07)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.99–1.03)</td><td align="char" valign="top" char="." charoff="50">0.51</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.95–1.04)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.99–1.04)</td><td align="char" valign="top" char="." charoff="50">0.39</td></tr><tr><td align="left" valign="top" charoff="50">rs4733930</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.42</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.97–1.03)</td><td align="char" valign="top" char="(" charoff="50">1.04 (1.00–1.08)</td><td align="char" valign="top" char="(" charoff="50">1.02 (1.00–1.04)</td><td align="char" valign="top" char="." charoff="50">0.11</td><td align="char" valign="top" char="(" charoff="50">1.03 (0.99–1.07)</td><td align="char" valign="top" char="(" charoff="50">1.02 (1.00–1.04)</td><td align="char" valign="top" char="." charoff="50">0.67</td></tr><tr><td align="left" valign="top" charoff="50">rs4733946</td><td align="center" valign="top" charoff="50">C<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.08</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.97–1.03)</td><td align="char" valign="top" char="(" charoff="50">1.04 (1.00–1.08)</td><td align="char" valign="top" char="(" charoff="50">1.02 (1.00–1.04)</td><td align="char" valign="top" char="." charoff="50">0.11</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.95–1.08)</td><td align="char" valign="top" char="(" charoff="50">1.04 (1.00–1.09)</td><td align="char" valign="top" char="." charoff="50">0.39</td></tr><tr><td align="left" valign="top" charoff="50">rs6474354</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.21</td><td align="char" valign="top" char="(" charoff="50">0.98 (0.95–1.01)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.92–1.05)</td><td align="char" valign="top" char="(" charoff="50">0.98 (0.96–1.01)</td><td align="char" valign="top" char="." charoff="50">0.18</td><td align="char" valign="top" char="(" charoff="50">0.96 (0.92–1.01)</td><td align="char" valign="top" char="(" charoff="50">0.98 (0.96–1.01)</td><td align="char" valign="top" char="." charoff="50">0.37</td></tr><tr><td align="left" valign="top" charoff="50">rs6996321</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.39</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.98–1.04)</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.96–1.04)</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.98–1.02)</td><td align="char" valign="top" char="." charoff="50">0.95</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.97–1.04)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.97–1.02)</td><td align="char" valign="top" char="." charoff="50">0.54</td></tr><tr><td align="left" valign="top" charoff="50">rs6983315</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.44</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.97–1.04)</td><td align="char" valign="top" char="(" charoff="50">0.98 (0.94–1.02)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.97–1.01)</td><td align="char" valign="top" char="." charoff="50">0.39</td><td align="char" valign="top" char="(" charoff="50">0.97 (0.93–1.00)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.97–1.02)</td><td align="char" valign="top" char="." charoff="50">0.13</td></tr><tr><td align="left" valign="top" charoff="50">rs7012413<hr></hr></td><td align="center" valign="top" charoff="50">G<bold>A</bold><hr></hr></td><td align="char" valign="top" char="." charoff="50">0.30<hr></hr></td><td align="char" valign="top" char="(" charoff="50">1.00 (0.97–1.02)<hr></hr></td><td align="char" valign="top" char="(" charoff="50">0.99 (0.95–1.04)<hr></hr></td><td align="char" valign="top" char="(" charoff="50">1.00 (0.98–1.02)<hr></hr></td><td align="char" valign="top" char="." charoff="50">0.69<hr></hr></td><td align="char" valign="top" char="(" charoff="50">1.00 (0.97–1.04)<hr></hr></td><td align="char" valign="top" char="(" charoff="50">1.00 (0.98–1.02)<hr></hr></td><td align="char" valign="top" char="." charoff="50">0.82<hr></hr></td></tr><tr><td colspan="10" align="left" valign="top" charoff="50"><bold><italic>FGFR3</italic></bold><hr></hr></td></tr><tr><td align="left" valign="top" charoff="50">rs12502543</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.10</td><td align="char" valign="top" char="(" charoff="50">1.04 (1.01–1.08)</td><td align="char" valign="top" char="(" charoff="50">1.10 (0.96–1.25)</td><td align="char" valign="top" char="(" charoff="50">1.04 (1.01–1.08)</td><td align="char" valign="top" char="." charoff="50">0.0076</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.93–1.05)</td><td align="char" valign="top" char="(" charoff="50">1.06 (1.02–1.10)</td><td align="char" valign="top" char="." charoff="50">0.036</td></tr><tr><td align="left" valign="top" charoff="50">rs2234909</td><td align="center" valign="top" charoff="50">A<bold>G</bold></td><td align="char" valign="top" char="." charoff="50">0.14</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.95–1.02)</td><td align="char" valign="top" char="(" charoff="50">0.97 (0.88–1.07)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.96–1.01)</td><td align="char" valign="top" char="." charoff="50">0.29</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.94–1.04)</td><td align="char" valign="top" char="(" charoff="50">0.98 (0.95–1.02)</td><td align="char" valign="top" char="." charoff="50">0.77</td></tr><tr><td align="left" valign="top" charoff="50">rs3135848</td><td align="center" valign="top" charoff="50">A<bold>G</bold></td><td align="char" valign="top" char="." charoff="50">0.28</td><td align="char" valign="top" char="(" charoff="50">1.02 (0.99–1.04)</td><td align="char" valign="top" char="(" charoff="50">1.02 (0.96–1.07)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.99–1.03)</td><td align="char" valign="top" char="." charoff="50">0.31</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.96–1.04)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.99–1.04)</td><td align="char" valign="top" char="." charoff="50">0.55</td></tr><tr><td align="left" valign="top" charoff="50">rs743682</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.09</td><td align="char" valign="top" char="(" charoff="50">1.05 (1.01–1.09)</td><td align="char" valign="top" char="(" charoff="50">1.16 (1.00–1.34)</td><td align="char" valign="top" char="(" charoff="50">1.05 (1.02–1.09)</td><td align="char" valign="top" char="." charoff="50">0.0020</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.95–1.08)</td><td align="char" valign="top" char="(" charoff="50">1.06 (1.02–1.10)</td><td align="char" valign="top" char="." charoff="50">0.24</td></tr><tr><td align="left" valign="top" charoff="50">rs746779<hr></hr></td><td align="center" valign="top" charoff="50">G<bold>A</bold><hr></hr></td><td align="char" valign="top" char="." charoff="50">0.18<hr></hr></td><td align="char" valign="top" char="(" charoff="50">0.99 (0.96–1.02)<hr></hr></td><td align="char" valign="top" char="(" charoff="50">0.98 (0.90–1.06)<hr></hr></td><td align="char" valign="top" char="(" charoff="50">0.99 (0.96–1.01)<hr></hr></td><td align="char" valign="top" char="." charoff="50">0.29<hr></hr></td><td align="char" valign="top" char="(" charoff="50">1.00 (0.95–1.05)<hr></hr></td><td align="char" valign="top" char="(" charoff="50">0.98 (0.95–1.01)<hr></hr></td><td align="char" valign="top" char="." charoff="50">0.48<hr></hr></td></tr><tr><td colspan="10" align="left" valign="top" charoff="50"><bold><italic>FGFR4</italic></bold><hr></hr></td></tr><tr><td align="left" valign="top" charoff="50">rs1076891</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.06</td><td align="char" valign="top" char="(" charoff="50">1.03 (0.99–1.08)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.81–1.22)</td><td align="char" valign="top" char="(" charoff="50">1.03 (0.99–1.07)</td><td align="char" valign="top" char="." charoff="50">0.14</td><td align="char" valign="top" char="(" charoff="50">1.06 (0.98–1.14)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.97–1.06)</td><td align="char" valign="top" char="." charoff="50">0.25</td></tr><tr><td align="left" valign="top" charoff="50">rs1966265</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.23</td><td align="char" valign="top" char="(" charoff="50">0.97 (0.94–1.00)</td><td align="char" valign="top" char="(" charoff="50">0.93 (0.88–0.99)</td><td align="char" valign="top" char="(" charoff="50">0.97 (0.95–0.99)</td><td align="char" valign="top" char="." charoff="50">0.0060</td><td align="char" valign="top" char="(" charoff="50">0.98 (0.94–1.03)</td><td align="char" valign="top" char="(" charoff="50">0.97 (0.95–1.00)</td><td align="char" valign="top" char="." charoff="50">0.54</td></tr><tr><td align="left" valign="top" charoff="50">rs2456173</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.21</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.97–1.03)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.92–1.05)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.97–1.02)</td><td align="char" valign="top" char="." charoff="50">0.66</td><td align="char" valign="top" char="(" charoff="50">0.98 (0.94–1.02)</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.98–1.03)</td><td align="char" valign="top" char="." charoff="50">0.34</td></tr><tr><td align="left" valign="top" charoff="50">rs376618</td><td align="center" valign="top" charoff="50">A<bold>G</bold></td><td align="char" valign="top" char="." charoff="50">0.24</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.97–1.03)</td><td align="char" valign="top" char="(" charoff="50">0.96 (0.91–1.02)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.97–1.01)</td><td align="char" valign="top" char="." charoff="50">0.33</td><td align="char" valign="top" char="(" charoff="50">0.97 (0.93–1.01)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.97–1.02)</td><td align="char" valign="top" char="." charoff="50">0.29</td></tr><tr><td align="left" valign="top" charoff="50">rs641101</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.31</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.98–1.04)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.94–1.03)</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.98–1.02)</td><td align="char" valign="top" char="." charoff="50">0.98</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.95–1.03)</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.98–1.02)</td><td align="char" valign="top" char="." charoff="50">0.56</td></tr><tr><td align="left" valign="top" charoff="50">rs6556301<hr></hr></td><td align="center" valign="top" charoff="50">C<bold>A</bold><hr></hr></td><td align="char" valign="top" char="." charoff="50">0.36<hr></hr></td><td align="char" valign="top" char="(" charoff="50">0.99 (0.97–1.02)<hr></hr></td><td align="char" valign="top" char="(" charoff="50">0.96 (0.92–1.00)<hr></hr></td><td align="char" valign="top" char="(" charoff="50">0.98 (0.97–1.00)<hr></hr></td><td align="char" valign="top" char="." charoff="50">0.13<hr></hr></td><td align="char" valign="top" char="(" charoff="50">0.99 (0.95–1.02)<hr></hr></td><td align="char" valign="top" char="(" charoff="50">0.98 (0.96–1.01)<hr></hr></td><td align="char" valign="top" char="." charoff="50">0.84<hr></hr></td></tr><tr><td colspan="10" align="left" valign="top" charoff="50"><bold><italic>FGFRL1</italic></bold><hr></hr></td></tr><tr><td align="left" valign="top" charoff="50">rs34869253</td><td align="center" valign="top" charoff="50">A<bold>G</bold></td><td align="char" valign="top" char="." charoff="50">0.43</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.97–1.04)</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.96–1.04)</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.98–1.02)</td><td align="char" valign="top" char="." charoff="50">0.96</td><td align="char" valign="top" char="(" charoff="50">0.98 (0.94–1.01)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.97–1.01)</td><td align="char" valign="top" char="." charoff="50">0.52</td></tr><tr><td align="left" valign="top" charoff="50">rs3755955</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.16</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.97–1.03)</td><td align="char" valign="top" char="(" charoff="50">1.02 (0.94–1.11)</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.98–1.03)</td><td align="char" valign="top" char="." charoff="50">0.82</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.95–1.05)</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.97–1.03)</td><td align="char" valign="top" char="." charoff="50">0.83</td></tr><tr><td align="left" valign="top" charoff="50">rs4505759</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.30</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.96–1.02)</td><td align="char" valign="top" char="(" charoff="50">0.98 (0.93–1.03)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.97–1.00)</td><td align="char" valign="top" char="." charoff="50">0.38</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.96–1.04)</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.97–1.02)</td><td align="char" valign="top" char="." charoff="50">0.78</td></tr><tr><td align="left" valign="top" charoff="50">rs4647932</td><td align="center" valign="top" charoff="50">G<bold>A</bold></td><td align="char" valign="top" char="." charoff="50">0.06</td><td align="char" valign="top" char="(" charoff="50">1.04 (0.99–1.08)</td><td align="char" valign="top" char="(" charoff="50">0.98 (0.80–1.20)</td><td align="char" valign="top" char="(" charoff="50">1.03 (0.99–1.07)</td><td align="char" valign="top" char="." charoff="50">0.14</td><td align="char" valign="top" char="(" charoff="50">1.06 (0.98–1.14)</td><td align="char" valign="top" char="(" charoff="50">1.02 (0.97–1.06)</td><td align="char" valign="top" char="." charoff="50">0.31</td></tr><tr><td align="left" valign="top" charoff="50">rs6855233</td><td align="center" valign="top" charoff="50">A<bold>G</bold></td><td align="char" valign="top" char="." charoff="50">0.29</td><td align="char" valign="top" char="(" charoff="50">0.99 (0.97–1.02)</td><td align="char" valign="top" char="(" charoff="50">1.03 (0.98–1.08)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.98–1.03)</td><td align="char" valign="top" char="." charoff="50">0.62</td><td align="char" valign="top" char="(" charoff="50">0.98 (0.94–1.02)</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.98–1.03)</td><td align="char" valign="top" char="." charoff="50">0.31</td></tr><tr><td align="left" valign="top" charoff="50">rs748651</td><td align="center" valign="top" charoff="50">A<bold>G</bold></td><td align="char" valign="top" char="." charoff="50">0.48</td><td align="char" valign="top" char="(" charoff="50">1.00 (0.97–1.03)</td><td align="char" valign="top" char="(" charoff="50">1.02 (0.98–1.06)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.99–1.03)</td><td align="char" valign="top" char="." charoff="50">0.31</td><td align="char" valign="top" char="(" charoff="50">1.03 (0.99–1.07)</td><td align="char" valign="top" char="(" charoff="50">1.01 (0.98–1.03)</td><td align="char" valign="top" char="." charoff="50">0.22</td></tr></tbody></table><table-wrap-foot><fn id="t2-fn1"><p>Abbreviations: SNP=single-nucleotide polymorphism; FGF=fibroblast growth factor; OR=odds ratio where A is the common allele, a is the rare allele and both Aa and aa are compared with AA genotypes; CI=confidence interval; MAF=minor allele frequency; <italic>P</italic>=<italic>P</italic>-value for the per-a-allele model; ER−=results (per a-allele) for risk of estrogen receptor-negative disease; ER+=results (per a-allele) for risk of estrogen receptor-positive disease; <italic>P-het</italic>=<italic>P</italic>-value for heterogeneity by disease sub-type defined by estrogen receptor 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