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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy</title><author><name sortKey="Bouzigon, Emmanuelle" sort="Bouzigon, Emmanuelle" uniqKey="Bouzigon E" first="Emmanuelle" last="Bouzigon">Emmanuelle Bouzigon</name><affiliation><nlm:aff id="aff1"><institution>INSERM, U946</institution>, Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Université Paris Diderot, Paris 7, Institut Universitaire d'Hématologie</institution>, Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Foundation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH)</institution>, Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Forabosco, Paola" sort="Forabosco, Paola" uniqKey="Forabosco P" first="Paola" last="Forabosco">Paola Forabosco</name><affiliation><nlm:aff id="aff4"><institution>King's College London, Department of Medical and Molecular Genetics</institution>, London,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Istituto di Genetica delle Popolazioni-CNR</institution>, Alghero,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H" last="Koppelman">Gerard H. Koppelman</name><affiliation><nlm:aff id="aff6"><institution>Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Cookson, William O C M" sort="Cookson, William O C M" uniqKey="Cookson W" first="William O C M" last="Cookson">William O C M. Cookson</name><affiliation><nlm:aff id="aff7"><institution>National Heart Lung Institute, Imperial College</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Dizier, Marie Helene" sort="Dizier, Marie Helene" uniqKey="Dizier M" first="Marie-Hélène" last="Dizier">Marie-Hélène Dizier</name><affiliation><nlm:aff id="aff8"><institution>INSERM, U535</institution>, Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff9"><institution>Univ Paris-Sud, IFR69</institution>, Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Duffy, David L" sort="Duffy, David L" uniqKey="Duffy D" first="David L" last="Duffy">David L. Duffy</name><affiliation><nlm:aff id="aff10"><institution>Queensland Institute of Medical Research, Royal Brisbane Hospital</institution>, Brisbane,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><affiliation><nlm:aff id="aff11"><institution>Department of Social Medicine, University of Bristol</institution>, Bristol,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Ferreira, Manuel A R" sort="Ferreira, Manuel A R" uniqKey="Ferreira M" first="Manuel A R" last="Ferreira">Manuel A R. Ferreira</name><affiliation><nlm:aff id="aff10"><institution>Queensland Institute of Medical Research, Royal Brisbane Hospital</institution>, Brisbane,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Kere, Juha" sort="Kere, Juha" uniqKey="Kere J" first="Juha" last="Kere">Juha Kere</name><affiliation><nlm:aff id="aff12"><institution>Department of Biosciences and Nutrition, Karolinska Institute</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Laitinen, Tarja" sort="Laitinen, Tarja" uniqKey="Laitinen T" first="Tarja" last="Laitinen">Tarja Laitinen</name><affiliation><nlm:aff id="aff13"><institution>Departments of Pulmonary Medicine and Medical Genetics, University of Helsinki</institution>, Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Malerba, Giovanni" sort="Malerba, Giovanni" uniqKey="Malerba G" first="Giovanni" last="Malerba">Giovanni Malerba</name><affiliation><nlm:aff id="aff14"><institution>Section of Biology and Genetics, Department of Mother and Child, and Biology-Genetics, University of Verona</institution>, Verona,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Meyers, Deborah A" sort="Meyers, Deborah A" uniqKey="Meyers D" first="Deborah A" last="Meyers">Deborah A. Meyers</name><affiliation><nlm:aff id="aff15"><institution>Center for Human Genomics, Wake Forest University</institution>, Winston Salem, NC,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam" sort="Moffatt, Miriam" uniqKey="Moffatt M" first="Miriam" last="Moffatt">Miriam Moffatt</name><affiliation><nlm:aff id="aff7"><institution>National Heart Lung Institute, Imperial College</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="aff10"><institution>Queensland Institute of Medical Research, Royal Brisbane Hospital</institution>, Brisbane,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Ng, Mandy Y" sort="Ng, Mandy Y" uniqKey="Ng M" first="Mandy Y" last="Ng">Mandy Y. Ng</name><affiliation><nlm:aff id="aff16"><institution>King's College London, MRC SGDP Centre, Institute of Psychiatry</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Pignatti, Pier Franco" sort="Pignatti, Pier Franco" uniqKey="Pignatti P" first="Pier Franco" last="Pignatti">Pier Franco Pignatti</name><affiliation><nlm:aff id="aff14"><institution>Section of Biology and Genetics, Department of Mother and Child, and Biology-Genetics, University of Verona</institution>, Verona,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Wjst, Mathias" sort="Wjst, Mathias" uniqKey="Wjst M" first="Mathias" last="Wjst">Mathias Wjst</name><affiliation><nlm:aff id="aff17"><institution>Institute of Experimental Pneumology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Neuherberg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff18"><institution>Institute of Genetic Medicine, EURAC research</institution>, Bozen,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Kauffmann, Francine" sort="Kauffmann, Francine" uniqKey="Kauffmann F" first="Francine" last="Kauffmann">Francine Kauffmann</name><affiliation><nlm:aff id="aff9"><institution>Univ Paris-Sud, IFR69</institution>, Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff19"><institution>INSERM, U780</institution>, Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation><nlm:aff id="aff1"><institution>INSERM, U946</institution>, Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Université Paris Diderot, Paris 7, Institut Universitaire d'Hématologie</institution>, Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Foundation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH)</institution>, Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M" last="Lewis">Cathryn M. Lewis</name><affiliation><nlm:aff id="aff4"><institution>King's College London, Department of Medical and Molecular Genetics</institution>, London,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff16"><institution>King's College London, MRC SGDP Centre, Institute of Psychiatry</institution>, London,<country>UK</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20068594</idno><idno type="pmc">2987334</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987334</idno><idno type="RBID">PMC:2987334</idno><idno type="doi">10.1038/ejhg.2009.224</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000054</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000054</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy</title><author><name sortKey="Bouzigon, Emmanuelle" sort="Bouzigon, Emmanuelle" uniqKey="Bouzigon E" first="Emmanuelle" last="Bouzigon">Emmanuelle Bouzigon</name><affiliation><nlm:aff id="aff1"><institution>INSERM, U946</institution>, Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Université Paris Diderot, Paris 7, Institut Universitaire d'Hématologie</institution>, Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Foundation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH)</institution>, Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Forabosco, Paola" sort="Forabosco, Paola" uniqKey="Forabosco P" first="Paola" last="Forabosco">Paola Forabosco</name><affiliation><nlm:aff id="aff4"><institution>King's College London, Department of Medical and Molecular Genetics</institution>, London,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Istituto di Genetica delle Popolazioni-CNR</institution>, Alghero,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H" last="Koppelman">Gerard H. Koppelman</name><affiliation><nlm:aff id="aff6"><institution>Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Cookson, William O C M" sort="Cookson, William O C M" uniqKey="Cookson W" first="William O C M" last="Cookson">William O C M. Cookson</name><affiliation><nlm:aff id="aff7"><institution>National Heart Lung Institute, Imperial College</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Dizier, Marie Helene" sort="Dizier, Marie Helene" uniqKey="Dizier M" first="Marie-Hélène" last="Dizier">Marie-Hélène Dizier</name><affiliation><nlm:aff id="aff8"><institution>INSERM, U535</institution>, Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff9"><institution>Univ Paris-Sud, IFR69</institution>, Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Duffy, David L" sort="Duffy, David L" uniqKey="Duffy D" first="David L" last="Duffy">David L. Duffy</name><affiliation><nlm:aff id="aff10"><institution>Queensland Institute of Medical Research, Royal Brisbane Hospital</institution>, Brisbane,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><affiliation><nlm:aff id="aff11"><institution>Department of Social Medicine, University of Bristol</institution>, Bristol,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Ferreira, Manuel A R" sort="Ferreira, Manuel A R" uniqKey="Ferreira M" first="Manuel A R" last="Ferreira">Manuel A R. Ferreira</name><affiliation><nlm:aff id="aff10"><institution>Queensland Institute of Medical Research, Royal Brisbane Hospital</institution>, Brisbane,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Kere, Juha" sort="Kere, Juha" uniqKey="Kere J" first="Juha" last="Kere">Juha Kere</name><affiliation><nlm:aff id="aff12"><institution>Department of Biosciences and Nutrition, Karolinska Institute</institution>, Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Laitinen, Tarja" sort="Laitinen, Tarja" uniqKey="Laitinen T" first="Tarja" last="Laitinen">Tarja Laitinen</name><affiliation><nlm:aff id="aff13"><institution>Departments of Pulmonary Medicine and Medical Genetics, University of Helsinki</institution>, Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Malerba, Giovanni" sort="Malerba, Giovanni" uniqKey="Malerba G" first="Giovanni" last="Malerba">Giovanni Malerba</name><affiliation><nlm:aff id="aff14"><institution>Section of Biology and Genetics, Department of Mother and Child, and Biology-Genetics, University of Verona</institution>, Verona,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Meyers, Deborah A" sort="Meyers, Deborah A" uniqKey="Meyers D" first="Deborah A" last="Meyers">Deborah A. Meyers</name><affiliation><nlm:aff id="aff15"><institution>Center for Human Genomics, Wake Forest University</institution>, Winston Salem, NC,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam" sort="Moffatt, Miriam" uniqKey="Moffatt M" first="Miriam" last="Moffatt">Miriam Moffatt</name><affiliation><nlm:aff id="aff7"><institution>National Heart Lung Institute, Imperial College</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="aff10"><institution>Queensland Institute of Medical Research, Royal Brisbane Hospital</institution>, Brisbane,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Ng, Mandy Y" sort="Ng, Mandy Y" uniqKey="Ng M" first="Mandy Y" last="Ng">Mandy Y. Ng</name><affiliation><nlm:aff id="aff16"><institution>King's College London, MRC SGDP Centre, Institute of Psychiatry</institution>, London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Pignatti, Pier Franco" sort="Pignatti, Pier Franco" uniqKey="Pignatti P" first="Pier Franco" last="Pignatti">Pier Franco Pignatti</name><affiliation><nlm:aff id="aff14"><institution>Section of Biology and Genetics, Department of Mother and Child, and Biology-Genetics, University of Verona</institution>, Verona,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Wjst, Mathias" sort="Wjst, Mathias" uniqKey="Wjst M" first="Mathias" last="Wjst">Mathias Wjst</name><affiliation><nlm:aff id="aff17"><institution>Institute of Experimental Pneumology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Neuherberg,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff18"><institution>Institute of Genetic Medicine, EURAC research</institution>, Bozen,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Kauffmann, Francine" sort="Kauffmann, Francine" uniqKey="Kauffmann F" first="Francine" last="Kauffmann">Francine Kauffmann</name><affiliation><nlm:aff id="aff9"><institution>Univ Paris-Sud, IFR69</institution>, Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff19"><institution>INSERM, U780</institution>, Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation><nlm:aff id="aff1"><institution>INSERM, U946</institution>, Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Université Paris Diderot, Paris 7, Institut Universitaire d'Hématologie</institution>, Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Foundation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH)</institution>, Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M" last="Lewis">Cathryn M. Lewis</name><affiliation><nlm:aff id="aff4"><institution>King's College London, Department of Medical and Molecular Genetics</institution>, London,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff16"><institution>King's College London, MRC SGDP Centre, Institute of Psychiatry</institution>, London,<country>UK</country></nlm:aff></affiliation></author></analytic><series><title level="j">European Journal of Human Genetics</title><idno type="ISSN">1018-4813</idno><idno type="eISSN">1476-5438</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Asthma is caused by a heterogeneous combination of environmental and genetic factors. In the context of GA2LEN (Global Allergy and Asthma European Network), we carried out meta-analyses of almost all genome-wide linkage screens conducted to date in 20 independent populations from different ethnic origins (≥3024 families with ≥10 027 subjects) for asthma, atopic asthma, bronchial hyper-responsiveness and five atopy-related traits (total immunoglobulin E level, positive skin test response (SPT) to at least one allergen or to House Dust Mite, quantitative score of SPT (SPTQ) and eosinophils (EOS)). We used the genome scan meta-analysis method to assess evidence for linkage within bins of traditionally 30-cM width, and explored the manner in which these results were affected by bin definition. Meta-analyses were conducted in all studies and repeated in families of European ancestry. Genome-wide evidence for linkage was detected for asthma in two regions (2p21–p14 and 6p21) in European families ascertained through two asthmatic sibs. With regard to atopy phenotypes, four regions reached genome-wide significance: 3p25.3–q24 in all families for SPT and three other regions in European families (2q32–q34 for EOS, 5q23–q33 for SPTQ and 17q12–q24 for SPT). Tests of heterogeneity showed consistent evidence of linkage of SPTQ to 3p11–3q21, whereas between-study heterogeneity was detected for asthma in 2p22–p13 and 6p21, and for atopic asthma in 1q23–q25. This large-scale meta-analysis provides an important resource of information that can be used to prioritize further fine-mapping studies and also be integrated with genome-wide association studies to increase power and better interpret the outcomes of these studies.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Eur J Hum Genet</journal-id><journal-title-group><journal-title>European Journal of Human Genetics</journal-title></journal-title-group><issn pub-type="ppub">1018-4813</issn><issn pub-type="epub">1476-5438</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20068594</article-id><article-id pub-id-type="pmc">2987334</article-id><article-id pub-id-type="pii">ejhg2009224</article-id><article-id pub-id-type="doi">10.1038/ejhg.2009.224</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy</article-title><alt-title alt-title-type="running">Asthma and atopy genome linkage scan meta-analyses</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bouzigon</surname><given-names>Emmanuelle</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="corresp" rid="caf1">*</xref></contrib><contrib contrib-type="author"><name><surname>Forabosco</surname><given-names>Paola</given-names></name><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Koppelman</surname><given-names>Gerard H</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Cookson</surname><given-names>William O C M</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Dizier</surname><given-names>Marie-Hélène</given-names></name><xref ref-type="aff" rid="aff8">8</xref><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Duffy</surname><given-names>David L</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Evans</surname><given-names>David M</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Ferreira</surname><given-names>Manuel A R</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Kere</surname><given-names>Juha</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Laitinen</surname><given-names>Tarja</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Malerba</surname><given-names>Giovanni</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Meyers</surname><given-names>Deborah A</given-names></name><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Moffatt</surname><given-names>Miriam</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Nicholas G</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Ng</surname><given-names>Mandy Y</given-names></name><xref ref-type="aff" rid="aff16">16</xref></contrib><contrib contrib-type="author"><name><surname>Pignatti</surname><given-names>Pier Franco</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Wjst</surname><given-names>Mathias</given-names></name><xref ref-type="aff" rid="aff17">17</xref><xref ref-type="aff" rid="aff18">18</xref></contrib><contrib contrib-type="author"><name><surname>Kauffmann</surname><given-names>Francine</given-names></name><xref ref-type="aff" rid="aff9">9</xref><xref ref-type="aff" rid="aff19">19</xref></contrib><contrib contrib-type="author"><name><surname>Demenais</surname><given-names>Florence</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lewis</surname><given-names>Cathryn M</given-names></name><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="aff" rid="aff16">16</xref></contrib><aff id="aff1"><label>1</label><institution>INSERM, U946</institution>, Paris,<country>France</country></aff><aff id="aff2"><label>2</label><institution>Université Paris Diderot, Paris 7, Institut Universitaire d'Hématologie</institution>, Paris,<country>France</country></aff><aff id="aff3"><label>3</label><institution>Foundation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH)</institution>, Paris,<country>France</country></aff><aff id="aff4"><label>4</label><institution>King's College London, Department of Medical and Molecular Genetics</institution>, London,<country>UK</country></aff><aff id="aff5"><label>5</label><institution>Istituto di Genetica delle Popolazioni-CNR</institution>, Alghero,<country>Italy</country></aff><aff id="aff6"><label>6</label><institution>Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen</institution>, Groningen,<country>The Netherlands</country></aff><aff id="aff7"><label>7</label><institution>National Heart Lung Institute, Imperial College</institution>, London,<country>UK</country></aff><aff id="aff8"><label>8</label><institution>INSERM, U535</institution>, Villejuif,<country>France</country></aff><aff id="aff9"><label>9</label><institution>Univ Paris-Sud, IFR69</institution>, Villejuif,<country>France</country></aff><aff id="aff10"><label>10</label><institution>Queensland Institute of Medical Research, Royal Brisbane Hospital</institution>, Brisbane,<country>Australia</country></aff><aff id="aff11"><label>11</label><institution>Department of Social Medicine, University of Bristol</institution>, Bristol,<country>UK</country></aff><aff id="aff12"><label>12</label><institution>Department of Biosciences and Nutrition, Karolinska Institute</institution>, Stockholm,<country>Sweden</country></aff><aff id="aff13"><label>13</label><institution>Departments of Pulmonary Medicine and Medical Genetics, University of Helsinki</institution>, Helsinki,<country>Finland</country></aff><aff id="aff14"><label>14</label><institution>Section of Biology and Genetics, Department of Mother and Child, and Biology-Genetics, University of Verona</institution>, Verona,<country>Italy</country></aff><aff id="aff15"><label>15</label><institution>Center for Human Genomics, Wake Forest University</institution>, Winston Salem, NC,<country>USA</country></aff><aff id="aff16"><label>16</label><institution>King's College London, MRC SGDP Centre, Institute of Psychiatry</institution>, London,<country>UK</country></aff><aff id="aff17"><label>17</label><institution>Institute of Experimental Pneumology, Helmholtz Zentrum München, German Research Center for Environmental Health</institution>, Neuherberg,<country>Germany</country></aff><aff id="aff18"><label>18</label><institution>Institute of Genetic Medicine, EURAC research</institution>, Bozen,<country>Italy</country></aff><aff id="aff19"><label>19</label><institution>INSERM, U780</institution>, Villejuif,<country>France</country></aff></contrib-group><author-notes><corresp id="caf1"><label>*</label><institution>INSERM U946, Fondation Jean Dausset-CEPH</institution>, 27 rue Juliette Dodu, 75010 Paris, <country>France</country>. Tel: +33 1 53725023; Fax: +33 1 53725049; E-mail: <email>emmanuelle.bouzigon@inserm.fr</email></corresp></author-notes><pub-date pub-type="ppub"><month>06</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>13</day><month>01</month><year>2010</year></pub-date><volume>18</volume><issue>6</issue><fpage>700</fpage><lpage>706</lpage><history><date date-type="received"><day>12</day><month>05</month><year>2009</year></date><date date-type="rev-recd"><day>29</day><month>09</month><year>2009</year></date><date date-type="accepted"><day>12</day><month>11</month><year>2009</year></date></history><permissions><copyright-statement>Copyright © 2010 Macmillan Publishers Limited</copyright-statement><copyright-year>2010</copyright-year><copyright-holder>Macmillan Publishers Limited</copyright-holder></permissions><abstract><p>Asthma is caused by a heterogeneous combination of environmental and genetic factors. In the context of GA2LEN (Global Allergy and Asthma European Network), we carried out meta-analyses of almost all genome-wide linkage screens conducted to date in 20 independent populations from different ethnic origins (≥3024 families with ≥10 027 subjects) for asthma, atopic asthma, bronchial hyper-responsiveness and five atopy-related traits (total immunoglobulin E level, positive skin test response (SPT) to at least one allergen or to House Dust Mite, quantitative score of SPT (SPTQ) and eosinophils (EOS)). We used the genome scan meta-analysis method to assess evidence for linkage within bins of traditionally 30-cM width, and explored the manner in which these results were affected by bin definition. Meta-analyses were conducted in all studies and repeated in families of European ancestry. Genome-wide evidence for linkage was detected for asthma in two regions (2p21–p14 and 6p21) in European families ascertained through two asthmatic sibs. With regard to atopy phenotypes, four regions reached genome-wide significance: 3p25.3–q24 in all families for SPT and three other regions in European families (2q32–q34 for EOS, 5q23–q33 for SPTQ and 17q12–q24 for SPT). Tests of heterogeneity showed consistent evidence of linkage of SPTQ to 3p11–3q21, whereas between-study heterogeneity was detected for asthma in 2p22–p13 and 6p21, and for atopic asthma in 1q23–q25. This large-scale meta-analysis provides an important resource of information that can be used to prioritize further fine-mapping studies and also be integrated with genome-wide association studies to increase power and better interpret the outcomes of these studies.</p></abstract><kwd-group><kwd>asthma</kwd><kwd>atopy</kwd><kwd>meta-analysis</kwd><kwd>linkage scan</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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