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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Essential role of Isd11 in mitochondrial iron–sulfur cluster synthesis on Isu scaffold proteins</title><author><name sortKey="Wiedemann, Nils" sort="Wiedemann, Nils" uniqKey="Wiedemann N" first="Nils" last="Wiedemann">Nils Wiedemann</name><affiliation><nlm:aff id="O1">Institut für Biochemie und Molekularbiologie, Universität Freiburg, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Urzica, Eugen" sort="Urzica, Eugen" uniqKey="Urzica E" first="Eugen" last="Urzica">Eugen Urzica</name><affiliation><nlm:aff id="O2">Institut für Zytobiologie und Zytopathologie, Philipps-Universität Marburg, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Guiard, Bernard" sort="Guiard, Bernard" uniqKey="Guiard B" first="Bernard" last="Guiard">Bernard Guiard</name><affiliation><nlm:aff id="O3">Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France</nlm:aff></affiliation></author><author><name sortKey="Muller, Hanne" sort="Muller, Hanne" uniqKey="Muller H" first="Hanne" last="Müller">Hanne Müller</name><affiliation><nlm:aff id="O1">Institut für Biochemie und Molekularbiologie, Universität Freiburg, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lohaus, Christiane" sort="Lohaus, Christiane" uniqKey="Lohaus C" first="Christiane" last="Lohaus">Christiane Lohaus</name><affiliation><nlm:aff id="O4">Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Meyer, Helmut E" sort="Meyer, Helmut E" uniqKey="Meyer H" first="Helmut E" last="Meyer">Helmut E. Meyer</name><affiliation><nlm:aff id="O4">Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Ryan, Michael T" sort="Ryan, Michael T" uniqKey="Ryan M" first="Michael T" last="Ryan">Michael T. Ryan</name><affiliation><nlm:aff id="O5">Department of Biochemistry, La Trobe University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Meisinger, Chris" sort="Meisinger, Chris" uniqKey="Meisinger C" first="Chris" last="Meisinger">Chris Meisinger</name><affiliation><nlm:aff id="O1">Institut für Biochemie und Molekularbiologie, Universität Freiburg, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Muhlenhoff, Ulrich" sort="Muhlenhoff, Ulrich" uniqKey="Muhlenhoff U" first="Ulrich" last="Mühlenhoff">Ulrich Mühlenhoff</name><affiliation><nlm:aff id="O2">Institut für Zytobiologie und Zytopathologie, Philipps-Universität Marburg, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lill, Roland" sort="Lill, Roland" uniqKey="Lill R" first="Roland" last="Lill">Roland Lill</name><affiliation><nlm:aff id="O2">Institut für Zytobiologie und Zytopathologie, Philipps-Universität Marburg, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Pfanner, Nikolaus" sort="Pfanner, Nikolaus" uniqKey="Pfanner N" first="Nikolaus" last="Pfanner">Nikolaus Pfanner</name><affiliation><nlm:aff id="O1">Institut für Biochemie und Molekularbiologie, Universität Freiburg, Freiburg, Germany</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16341089</idno><idno type="pmc">1356349</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356349</idno><idno type="RBID">PMC:1356349</idno><idno type="doi">10.1038/sj.emboj.7600906</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000044</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000044</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Essential role of Isd11 in mitochondrial iron–sulfur cluster synthesis on Isu scaffold proteins</title><author><name sortKey="Wiedemann, Nils" sort="Wiedemann, Nils" uniqKey="Wiedemann N" first="Nils" last="Wiedemann">Nils Wiedemann</name><affiliation><nlm:aff id="O1">Institut für Biochemie und Molekularbiologie, Universität Freiburg, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Urzica, Eugen" sort="Urzica, Eugen" uniqKey="Urzica E" first="Eugen" last="Urzica">Eugen Urzica</name><affiliation><nlm:aff id="O2">Institut für Zytobiologie und Zytopathologie, Philipps-Universität Marburg, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Guiard, Bernard" sort="Guiard, Bernard" uniqKey="Guiard B" first="Bernard" last="Guiard">Bernard Guiard</name><affiliation><nlm:aff id="O3">Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France</nlm:aff></affiliation></author><author><name sortKey="Muller, Hanne" sort="Muller, Hanne" uniqKey="Muller H" first="Hanne" last="Müller">Hanne Müller</name><affiliation><nlm:aff id="O1">Institut für Biochemie und Molekularbiologie, Universität Freiburg, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lohaus, Christiane" sort="Lohaus, Christiane" uniqKey="Lohaus C" first="Christiane" last="Lohaus">Christiane Lohaus</name><affiliation><nlm:aff id="O4">Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Meyer, Helmut E" sort="Meyer, Helmut E" uniqKey="Meyer H" first="Helmut E" last="Meyer">Helmut E. Meyer</name><affiliation><nlm:aff id="O4">Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Ryan, Michael T" sort="Ryan, Michael T" uniqKey="Ryan M" first="Michael T" last="Ryan">Michael T. Ryan</name><affiliation><nlm:aff id="O5">Department of Biochemistry, La Trobe University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Meisinger, Chris" sort="Meisinger, Chris" uniqKey="Meisinger C" first="Chris" last="Meisinger">Chris Meisinger</name><affiliation><nlm:aff id="O1">Institut für Biochemie und Molekularbiologie, Universität Freiburg, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Muhlenhoff, Ulrich" sort="Muhlenhoff, Ulrich" uniqKey="Muhlenhoff U" first="Ulrich" last="Mühlenhoff">Ulrich Mühlenhoff</name><affiliation><nlm:aff id="O2">Institut für Zytobiologie und Zytopathologie, Philipps-Universität Marburg, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lill, Roland" sort="Lill, Roland" uniqKey="Lill R" first="Roland" last="Lill">Roland Lill</name><affiliation><nlm:aff id="O2">Institut für Zytobiologie und Zytopathologie, Philipps-Universität Marburg, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Pfanner, Nikolaus" sort="Pfanner, Nikolaus" uniqKey="Pfanner N" first="Nikolaus" last="Pfanner">Nikolaus Pfanner</name><affiliation><nlm:aff id="O1">Institut für Biochemie und Molekularbiologie, Universität Freiburg, Freiburg, Germany</nlm:aff></affiliation></author></analytic><series><title level="j">The EMBO Journal</title><idno type="ISSN">0261-4189</idno><idno type="eISSN">1460-2075</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mitochondria are indispensable for cell viability; however, major mitochondrial functions including citric acid cycle and oxidative phosphorylation are dispensable. Most known essential mitochondrial proteins are involved in preprotein import and assembly, while the only known essential biosynthetic process performed by mitochondria is the biogenesis of iron–sulfur clusters (ISC). The components of the mitochondrial ISC-assembly machinery are derived from the prokaryotic ISC-assembly machinery. We have identified an essential mitochondrial matrix protein, Isd11 (YER048w-a), that is found in eukaryotes only. Isd11 is required for biogenesis of cellular Fe/S proteins and thus is a novel subunit of the mitochondrial ISC-assembly machinery. It forms a complex with the cysteine desulfurase Nfs1 and is required for formation of an Fe/S cluster on the Isu scaffold proteins. We conclude that Isd11 is an indispensable eukaryotic component of the mitochondrial machinery for biogenesis of Fe/S proteins.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">EMBO J</journal-id><journal-title>The EMBO Journal</journal-title><issn pub-type="ppub">0261-4189</issn><issn pub-type="epub">1460-2075</issn></journal-meta><article-meta><article-id pub-id-type="pmid">16341089</article-id><article-id pub-id-type="pmc">1356349</article-id><article-id pub-id-type="pii">7600906</article-id><article-id pub-id-type="doi">10.1038/sj.emboj.7600906</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Essential role of Isd11 in mitochondrial iron–sulfur cluster synthesis on Isu scaffold proteins</article-title><alt-title alt-title-type="short">Mitochondrial desulfurase complex</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wiedemann</surname><given-names>Nils</given-names></name><xref ref-type="aff" rid="O1">1</xref></contrib><contrib contrib-type="author"><name><surname>Urzica</surname><given-names>Eugen</given-names></name><xref ref-type="aff" rid="O2">2</xref></contrib><contrib contrib-type="author"><name><surname>Guiard</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="O3">3</xref></contrib><contrib contrib-type="author"><name><surname>Müller</surname><given-names>Hanne</given-names></name><xref ref-type="aff" rid="O1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lohaus</surname><given-names>Christiane</given-names></name><xref ref-type="aff" rid="O4">4</xref></contrib><contrib contrib-type="author"><name><surname>Meyer</surname><given-names>Helmut E</given-names></name><xref ref-type="aff" rid="O4">4</xref></contrib><contrib contrib-type="author"><name><surname>Ryan</surname><given-names>Michael T</given-names></name><xref ref-type="aff" rid="O5">5</xref></contrib><contrib contrib-type="author"><name><surname>Meisinger</surname><given-names>Chris</given-names></name><xref ref-type="aff" rid="O1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mühlenhoff</surname><given-names>Ulrich</given-names></name><xref ref-type="aff" rid="O2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lill</surname><given-names>Roland</given-names></name><xref ref-type="aff" rid="O2">2</xref></contrib><contrib contrib-type="author"><name><surname>Pfanner</surname><given-names>Nikolaus</given-names></name><xref ref-type="aff" rid="O1">1</xref><xref ref-type="corresp" rid="c1">a</xref></contrib><aff id="O1"><label>1</label>Institut für Biochemie und Molekularbiologie, Universität Freiburg, Freiburg, Germany</aff><aff id="O2"><label>2</label>Institut für Zytobiologie und Zytopathologie, Philipps-Universität Marburg, Marburg, Germany</aff><aff id="O3"><label>3</label>Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France</aff><aff id="O4"><label>4</label>Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany</aff><aff id="O5"><label>5</label>Department of Biochemistry, La Trobe University, Melbourne, Australia</aff></contrib-group><author-notes><corresp id="c1"><label>a</label>Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Strasse 7, 79104 Freiburg, Germany. Tel.: +49 761 203 5224; Fax: +49 761 203 5261; E-mail: <email>nikolaus.pfanner@biochemie.uni-freiburg.de</email></corresp></author-notes><pub-date pub-type="ppub"><day>11</day><month>01</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>08</day><month>12</month><year>2005</year></pub-date><volume>25</volume><issue>1</issue><fpage>184</fpage><lpage>195</lpage><history><date date-type="received"><day>9</day><month>08</month><year>2005</year></date><date date-type="accepted"><day>15</day><month>11</month><year>2005</year></date></history><copyright-statement>Copyright © 2006, European Molecular Biology Organization</copyright-statement><copyright-year>2006</copyright-year><abstract><p>Mitochondria are indispensable for cell viability; however, major mitochondrial functions including citric acid cycle and oxidative phosphorylation are dispensable. Most known essential mitochondrial proteins are involved in preprotein import and assembly, while the only known essential biosynthetic process performed by mitochondria is the biogenesis of iron–sulfur clusters (ISC). The components of the mitochondrial ISC-assembly machinery are derived from the prokaryotic ISC-assembly machinery. We have identified an essential mitochondrial matrix protein, Isd11 (YER048w-a), that is found in eukaryotes only. Isd11 is required for biogenesis of cellular Fe/S proteins and thus is a novel subunit of the mitochondrial ISC-assembly machinery. It forms a complex with the cysteine desulfurase Nfs1 and is required for formation of an Fe/S cluster on the Isu scaffold proteins. We conclude that Isd11 is an indispensable eukaryotic component of the mitochondrial machinery for biogenesis of Fe/S proteins.</p></abstract><kwd-group><kwd>essential cellular functions</kwd><kwd>Fe/S proteins</kwd><kwd>mitochondria</kwd><kwd><italic>Saccharomyces cerevisiae</italic></kwd></kwd-group><counts><page-count count="12"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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