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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genomewide Linkage Scan of 409 European-Ancestry and African American Families with Schizophrenia: Suggestive Evidence of Linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the Combined Sample</title><author><name sortKey="Suarez, Brian K" sort="Suarez, Brian K" uniqKey="Suarez B" first="Brian K." last="Suarez">Brian K. Suarez</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Duan, Jubao" sort="Duan, Jubao" uniqKey="Duan J" first="Jubao" last="Duan">Jubao Duan</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Sanders, Alan R" sort="Sanders, Alan R" uniqKey="Sanders A" first="Alan R." last="Sanders">Alan R. Sanders</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, IL;</nlm:aff></affiliation></author><author><name sortKey="Hinrichs, Anthony L" sort="Hinrichs, Anthony L" uniqKey="Hinrichs A" first="Anthony L." last="Hinrichs">Anthony L. Hinrichs</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Departments of Psychiatry and Genetics, Washington University, St. Louis;</nlm:aff></affiliation></author><author><name sortKey="Jin, Carol H" sort="Jin, Carol H" uniqKey="Jin C" first="Carol H." last="Jin">Carol H. Jin</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Departments of Psychiatry and Genetics, Washington University, St. Louis;</nlm:aff></affiliation></author><author><name sortKey="Hou, Cuiping" sort="Hou, Cuiping" uniqKey="Hou C" first="Cuiping" last="Hou">Cuiping Hou</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, IL;</nlm:aff></affiliation></author><author><name sortKey="Buccola, Nancy G" sort="Buccola, Nancy G" uniqKey="Buccola N" first="Nancy G." last="Buccola">Nancy G. Buccola</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">School of Nursing, Louisiana State University Health Sciences Center, New Orleans;</nlm:aff></affiliation></author><author><name sortKey="Hale, Nancy" sort="Hale, Nancy" uniqKey="Hale N" first="Nancy" last="Hale">Nancy Hale</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine, Iowa City;</nlm:aff></affiliation></author><author><name sortKey="Weilbaecher, Ann N" sort="Weilbaecher, Ann N" uniqKey="Weilbaecher A" first="Ann N." last="Weilbaecher">Ann N. Weilbaecher</name><affiliation><nlm:aff wicri:cut=", and" id="N0x8c00b20.0x99a8c20">Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University</nlm:aff></affiliation></author><author><name sortKey="Nertney, Deborah A" sort="Nertney, Deborah A" uniqKey="Nertney D" first="Deborah A." last="Nertney">Deborah A. Nertney</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Olincy, Ann" sort="Olincy, Ann" uniqKey="Olincy A" first="Ann" last="Olincy">Ann Olincy</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine, Denver;</nlm:aff></affiliation></author><author><name sortKey="Green, Susan" sort="Green, Susan" uniqKey="Green S" first="Susan" last="Green">Susan Green</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Atlanta VA Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta;</nlm:aff></affiliation></author><author><name sortKey="Schaffer, Arthur W" sort="Schaffer, Arthur W" uniqKey="Schaffer A" first="Arthur W." last="Schaffer">Arthur W. Schaffer</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Departments of Psychiatry and Genetics, Washington University, St. Louis;</nlm:aff></affiliation></author><author><name sortKey="Smith, Christopher J" sort="Smith, Christopher J" uniqKey="Smith C" first="Christopher J." last="Smith">Christopher J. Smith</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Department of Psychiatry, Mount Sinai School of Medicine, New York;</nlm:aff></affiliation></author><author><name sortKey="Hannah, Dominique E" sort="Hannah, Dominique E" uniqKey="Hannah D" first="Dominique E." last="Hannah">Dominique E. Hannah</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Rice, John P" sort="Rice, John P" uniqKey="Rice J" first="John P." last="Rice">John P. Rice</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Departments of Psychiatry and Genetics, Washington University, St. Louis;</nlm:aff></affiliation></author><author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Department of Medicine, University of Chicago, Chicago;</nlm:aff></affiliation></author><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Mowry, Bryan J" sort="Mowry, Bryan J" uniqKey="Mowry B" first="Bryan J." last="Mowry">Bryan J. Mowry</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Amin, Farooq" sort="Amin, Farooq" uniqKey="Amin F" first="Farooq" last="Amin">Farooq Amin</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Silverman, Jeremy M" sort="Silverman, Jeremy M" uniqKey="Silverman J" first="Jeremy M." last="Silverman">Jeremy M. Silverman</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Department of Psychiatry, Mount Sinai School of Medicine, New York;</nlm:aff></affiliation></author><author><name sortKey="Black, Donald W" sort="Black, Donald W" uniqKey="Black D" first="Donald W." last="Black">Donald W. Black</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine, Iowa City;</nlm:aff></affiliation></author><author><name sortKey="Byerley, William F" sort="Byerley, William F" uniqKey="Byerley W" first="William F." last="Byerley">William F. Byerley</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Crowe, Raymond R" sort="Crowe, Raymond R" uniqKey="Crowe R" first="Raymond R." last="Crowe">Raymond R. Crowe</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine, Iowa City;</nlm:aff></affiliation></author><author><name sortKey="Freedman, Robert" sort="Freedman, Robert" uniqKey="Freedman R" first="Robert" last="Freedman">Robert Freedman</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine, Denver;</nlm:aff></affiliation></author><author><name sortKey="Cloninger, C Robert" sort="Cloninger, C Robert" uniqKey="Cloninger C" first="C. Robert" last="Cloninger">C. Robert Cloninger</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Departments of Psychiatry and Genetics, Washington University, St. Louis;</nlm:aff></affiliation></author><author><name sortKey="Levinson, Douglas F" sort="Levinson, Douglas F" uniqKey="Levinson D" first="Douglas F." last="Levinson">Douglas F. Levinson</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Gejman, Pablo V" sort="Gejman, Pablo V" uniqKey="Gejman P" first="Pablo V." last="Gejman">Pablo V. Gejman</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, IL;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16400611</idno><idno type="pmc">1380238</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1380238</idno><idno type="RBID">PMC:1380238</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000037</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000037</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genomewide Linkage Scan of 409 European-Ancestry and African American Families with Schizophrenia: Suggestive Evidence of Linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the Combined Sample</title><author><name sortKey="Suarez, Brian K" sort="Suarez, Brian K" uniqKey="Suarez B" first="Brian K." last="Suarez">Brian K. Suarez</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Duan, Jubao" sort="Duan, Jubao" uniqKey="Duan J" first="Jubao" last="Duan">Jubao Duan</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Sanders, Alan R" sort="Sanders, Alan R" uniqKey="Sanders A" first="Alan R." last="Sanders">Alan R. Sanders</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, IL;</nlm:aff></affiliation></author><author><name sortKey="Hinrichs, Anthony L" sort="Hinrichs, Anthony L" uniqKey="Hinrichs A" first="Anthony L." last="Hinrichs">Anthony L. Hinrichs</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Departments of Psychiatry and Genetics, Washington University, St. Louis;</nlm:aff></affiliation></author><author><name sortKey="Jin, Carol H" sort="Jin, Carol H" uniqKey="Jin C" first="Carol H." last="Jin">Carol H. Jin</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Departments of Psychiatry and Genetics, Washington University, St. Louis;</nlm:aff></affiliation></author><author><name sortKey="Hou, Cuiping" sort="Hou, Cuiping" uniqKey="Hou C" first="Cuiping" last="Hou">Cuiping Hou</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, IL;</nlm:aff></affiliation></author><author><name sortKey="Buccola, Nancy G" sort="Buccola, Nancy G" uniqKey="Buccola N" first="Nancy G." last="Buccola">Nancy G. Buccola</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">School of Nursing, Louisiana State University Health Sciences Center, New Orleans;</nlm:aff></affiliation></author><author><name sortKey="Hale, Nancy" sort="Hale, Nancy" uniqKey="Hale N" first="Nancy" last="Hale">Nancy Hale</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine, Iowa City;</nlm:aff></affiliation></author><author><name sortKey="Weilbaecher, Ann N" sort="Weilbaecher, Ann N" uniqKey="Weilbaecher A" first="Ann N." last="Weilbaecher">Ann N. Weilbaecher</name><affiliation><nlm:aff wicri:cut=", and" id="N0x8c00b20.0x99a8c20">Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University</nlm:aff></affiliation></author><author><name sortKey="Nertney, Deborah A" sort="Nertney, Deborah A" uniqKey="Nertney D" first="Deborah A." last="Nertney">Deborah A. Nertney</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Olincy, Ann" sort="Olincy, Ann" uniqKey="Olincy A" first="Ann" last="Olincy">Ann Olincy</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine, Denver;</nlm:aff></affiliation></author><author><name sortKey="Green, Susan" sort="Green, Susan" uniqKey="Green S" first="Susan" last="Green">Susan Green</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Atlanta VA Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta;</nlm:aff></affiliation></author><author><name sortKey="Schaffer, Arthur W" sort="Schaffer, Arthur W" uniqKey="Schaffer A" first="Arthur W." last="Schaffer">Arthur W. Schaffer</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Departments of Psychiatry and Genetics, Washington University, St. Louis;</nlm:aff></affiliation></author><author><name sortKey="Smith, Christopher J" sort="Smith, Christopher J" uniqKey="Smith C" first="Christopher J." last="Smith">Christopher J. Smith</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Department of Psychiatry, Mount Sinai School of Medicine, New York;</nlm:aff></affiliation></author><author><name sortKey="Hannah, Dominique E" sort="Hannah, Dominique E" uniqKey="Hannah D" first="Dominique E." last="Hannah">Dominique E. Hannah</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Rice, John P" sort="Rice, John P" uniqKey="Rice J" first="John P." last="Rice">John P. Rice</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Departments of Psychiatry and Genetics, Washington University, St. Louis;</nlm:aff></affiliation></author><author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Department of Medicine, University of Chicago, Chicago;</nlm:aff></affiliation></author><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Mowry, Bryan J" sort="Mowry, Bryan J" uniqKey="Mowry B" first="Bryan J." last="Mowry">Bryan J. Mowry</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Amin, Farooq" sort="Amin, Farooq" uniqKey="Amin F" first="Farooq" last="Amin">Farooq Amin</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Silverman, Jeremy M" sort="Silverman, Jeremy M" uniqKey="Silverman J" first="Jeremy M." last="Silverman">Jeremy M. Silverman</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Department of Psychiatry, Mount Sinai School of Medicine, New York;</nlm:aff></affiliation></author><author><name sortKey="Black, Donald W" sort="Black, Donald W" uniqKey="Black D" first="Donald W." last="Black">Donald W. Black</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine, Iowa City;</nlm:aff></affiliation></author><author><name sortKey="Byerley, William F" sort="Byerley, William F" uniqKey="Byerley W" first="William F." last="Byerley">William F. Byerley</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Crowe, Raymond R" sort="Crowe, Raymond R" uniqKey="Crowe R" first="Raymond R." last="Crowe">Raymond R. Crowe</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine, Iowa City;</nlm:aff></affiliation></author><author><name sortKey="Freedman, Robert" sort="Freedman, Robert" uniqKey="Freedman R" first="Robert" last="Freedman">Robert Freedman</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine, Denver;</nlm:aff></affiliation></author><author><name sortKey="Cloninger, C Robert" sort="Cloninger, C Robert" uniqKey="Cloninger C" first="C. Robert" last="Cloninger">C. Robert Cloninger</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Departments of Psychiatry and Genetics, Washington University, St. Louis;</nlm:aff></affiliation></author><author><name sortKey="Levinson, Douglas F" sort="Levinson, Douglas F" uniqKey="Levinson D" first="Douglas F." last="Levinson">Douglas F. Levinson</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Gejman, Pablo V" sort="Gejman, Pablo V" uniqKey="Gejman P" first="Pablo V." last="Gejman">Pablo V. Gejman</name><affiliation><nlm:aff id="N0x8c00b20.0x99a8c20">Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, IL;</nlm:aff></affiliation></author></analytic><series><title level="j">American Journal of Human Genetics</title><idno type="ISSN">0002-9297</idno><idno type="eISSN">1537-6605</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We report the clinical characteristics of a schizophrenia sample of 409 pedigrees—263 of European ancestry (EA) and 146 of African American ancestry (AA)—together with the results of a genome scan (with a simple tandem repeat polymorphism interval of 9 cM) and follow-up fine mapping. A family was required to have a proband with schizophrenia (SZ) and one or more siblings of the proband with SZ or schizoaffective disorder. Linkage analyses included 403 independent full-sibling affected sibling pairs (ASPs) (279 EA and 124 AA) and 100 all-possible half-sibling ASPs (15 EA and 85 AA). Nonparametric multipoint linkage analysis of all families detected two regions with suggestive evidence of linkage at 8p23.3-q12 and 11p11.2-q22.3 (empirical <italic>Z</italic> likelihood-ratio score [<italic>Z</italic><sub>lr</sub>] threshold ⩾2.65) and, in exploratory analyses, two other regions at 4p16.1-p15.32 in AA families and at 5p14.3-q11.2 in EA families. The most significant linkage peak was in chromosome 8p; its signal was mainly driven by the EA families. <italic>Z</italic><sub>lr</sub> scores >2.0 in 8p were observed from 30.7 cM to 61.7 cM (Center for Inherited Disease Research map locations). The maximum evidence in the full sample was a multipoint <italic>Z</italic><sub>lr</sub> of 3.25 (equivalent Kong-Cox LOD of 2.30) near <italic>D8S1771</italic> (at 52 cM); there appeared to be two peaks, both telomeric to <italic>neuregulin 1</italic> (<italic>NRG1</italic>). There is a paracentric inversion common in EA individuals within this region, the effect of which on the linkage evidence remains unknown in this and in other previously analyzed samples. Fine mapping of 8p did not significantly alter the significance or length of the peak. We also performed fine mapping of 4p16.3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in <italic>Z</italic><sub>lr</sub> scores was observed for 5p14.1-q12.1, where the maximum <italic>Z</italic><sub>lr</sub> increased from 2.77 initially to 3.80 after fine mapping in the EA families.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Hum Genet</journal-id><journal-id journal-id-type="publisher-id">AJHG</journal-id><journal-title>American Journal of Human Genetics</journal-title><issn pub-type="ppub">0002-9297</issn><issn pub-type="epub">1537-6605</issn><publisher><publisher-name>The American Society of Human Genetics</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16400611</article-id><article-id pub-id-type="pmc">1380238</article-id><article-id pub-id-type="publisher-id">42806</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Genomewide Linkage Scan of 409 European-Ancestry and African American Families with Schizophrenia: Suggestive Evidence of Linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the Combined Sample</article-title><alt-title>MGS1 Schizophrenia Linkage Scan</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Suarez</surname><given-names>Brian K.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">1,</xref><xref ref-type="fn" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Duan</surname><given-names>Jubao</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">2,</xref><xref ref-type="fn" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Sanders</surname><given-names>Alan R.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">2</xref></contrib><contrib contrib-type="author"><name><surname>Hinrichs</surname><given-names>Anthony L.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">1</xref></contrib><contrib contrib-type="author"><name><surname>Jin</surname><given-names>Carol H.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">1</xref></contrib><contrib contrib-type="author"><name><surname>Hou</surname><given-names>Cuiping</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">2</xref></contrib><contrib contrib-type="author"><name><surname>Buccola</surname><given-names>Nancy G.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">3</xref></contrib><contrib contrib-type="author"><name><surname>Hale</surname><given-names>Nancy</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">4</xref></contrib><contrib contrib-type="author"><name><surname>Weilbaecher</surname><given-names>Ann N.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">5</xref></contrib><contrib contrib-type="author"><name><surname>Nertney</surname><given-names>Deborah A.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">7,8</xref></contrib><contrib contrib-type="author"><name><surname>Olincy</surname><given-names>Ann</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">9</xref></contrib><contrib contrib-type="author"><name><surname>Green</surname><given-names>Susan</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">10</xref></contrib><contrib contrib-type="author"><name><surname>Schaffer</surname><given-names>Arthur W.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">1</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Christopher J.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">11</xref></contrib><contrib contrib-type="author"><name><surname>Hannah</surname><given-names>Dominique E.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">7,8</xref></contrib><contrib contrib-type="author"><name><surname>Rice</surname><given-names>John P.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">1</xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Nancy J.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">6</xref></contrib><contrib contrib-type="author"><name><surname>Martinez</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">2,12</xref></contrib><contrib contrib-type="author"><name><surname>Mowry</surname><given-names>Bryan J.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">7,8</xref></contrib><contrib contrib-type="author"><name><surname>Amin</surname><given-names>Farooq</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">10,13,</xref><xref ref-type="fn" rid="FN2">†</xref></contrib><contrib contrib-type="author"><name><surname>Silverman</surname><given-names>Jeremy M.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">11</xref></contrib><contrib contrib-type="author"><name><surname>Black</surname><given-names>Donald W.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">4</xref></contrib><contrib contrib-type="author"><name><surname>Byerley</surname><given-names>William F.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">14,15,</xref><xref ref-type="fn" rid="FN3">‡</xref></contrib><contrib contrib-type="author"><name><surname>Crowe</surname><given-names>Raymond R.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">4</xref></contrib><contrib contrib-type="author"><name><surname>Freedman</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">9</xref></contrib><contrib contrib-type="author"><name><surname>Cloninger</surname><given-names>C. Robert</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">1</xref></contrib><contrib contrib-type="author"><name><surname>Levinson</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">16,</xref><xref ref-type="fn" rid="FN4">§</xref></contrib><contrib contrib-type="author"><name><surname>Gejman</surname><given-names>Pablo V.</given-names></name><xref ref-type="aff" rid="N0x8c00b20.0x99a8c20">2</xref></contrib></contrib-group><aff id="N0x8c00b20.0x99a8c20"><sup>1</sup>Departments of Psychiatry and Genetics, Washington University, St. Louis;<sup>2</sup>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, IL;<sup>3</sup>School of Nursing, Louisiana State University Health Sciences Center, New Orleans;<sup>4</sup>Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine, Iowa City;<sup>5</sup>Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, and<sup>6</sup>Department of Medicine, University of Chicago, Chicago;<sup>7</sup>Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health, Wacol, Australia;<sup>8</sup>Department of Psychiatry, University of Queensland, Brisbane;<sup>9</sup>Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine, Denver;<sup>10</sup>Atlanta VA Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta;<sup>11</sup>Department of Psychiatry, Mount Sinai School of Medicine, New York;<sup>12</sup>Méthodologie Statistique et Epidémiologie Génétique des Maladies Multifactorielles, Institut National de la Recherche et de la Santé Médicale, Evry, France;<sup>13</sup>Baylor College of Medicine, Houston;<sup>14</sup>Department of Psychiatry, University of California at Irvine, Irvine;<sup>15</sup>Department of Psychiatry, University of California–San Francisco, San Francisco; and<sup>16</sup>Department of Psychiatry, University of Pennsylvania, Philadelphia</aff><author-notes><corresp>Address for correspondence and reprints: Dr. Pablo V. Gejman, Evanston Northwestern Healthcare Research Institute, 1001 University Place, Evanston, IL 60201-3137. E-mail: <email>pgejman@northwestern.edu</email></corresp><fn id="FN1"><label>*</label><p>These two authors contributed equally to this work.</p></fn><fn id="FN2"><label>†</label><p>Present affiliation: Atlanta VA Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta.</p></fn><fn id="FN3"><label>‡</label><p>Present affiliation: Department of Psychiatry, University of California–San Francisco, San Francisco.</p></fn><fn id="FN4"><label>§</label><p>Present affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto.</p></fn></author-notes><pub-date pub-type="ppub"><month>2</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>3</day><month>1</month><year>2006</year></pub-date><volume>78</volume><issue>2</issue><fpage>315</fpage><lpage>333</lpage><history><date date-type="received"><day>14</day><month>11</month><year>2005</year></date><date date-type="accepted"><day>6</day><month>12</month><year>2005</year></date></history><copyright-statement>© 2006 by The American Society of Human Genetics. All rights reserved.</copyright-statement><copyright-year>2006</copyright-year><self-uri>16400611</self-uri><abstract><p>We report the clinical characteristics of a schizophrenia sample of 409 pedigrees—263 of European ancestry (EA) and 146 of African American ancestry (AA)—together with the results of a genome scan (with a simple tandem repeat polymorphism interval of 9 cM) and follow-up fine mapping. A family was required to have a proband with schizophrenia (SZ) and one or more siblings of the proband with SZ or schizoaffective disorder. Linkage analyses included 403 independent full-sibling affected sibling pairs (ASPs) (279 EA and 124 AA) and 100 all-possible half-sibling ASPs (15 EA and 85 AA). Nonparametric multipoint linkage analysis of all families detected two regions with suggestive evidence of linkage at 8p23.3-q12 and 11p11.2-q22.3 (empirical <italic>Z</italic> likelihood-ratio score [<italic>Z</italic><sub>lr</sub>] threshold ⩾2.65) and, in exploratory analyses, two other regions at 4p16.1-p15.32 in AA families and at 5p14.3-q11.2 in EA families. The most significant linkage peak was in chromosome 8p; its signal was mainly driven by the EA families. <italic>Z</italic><sub>lr</sub> scores >2.0 in 8p were observed from 30.7 cM to 61.7 cM (Center for Inherited Disease Research map locations). The maximum evidence in the full sample was a multipoint <italic>Z</italic><sub>lr</sub> of 3.25 (equivalent Kong-Cox LOD of 2.30) near <italic>D8S1771</italic> (at 52 cM); there appeared to be two peaks, both telomeric to <italic>neuregulin 1</italic> (<italic>NRG1</italic>). There is a paracentric inversion common in EA individuals within this region, the effect of which on the linkage evidence remains unknown in this and in other previously analyzed samples. Fine mapping of 8p did not significantly alter the significance or length of the peak. We also performed fine mapping of 4p16.3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in <italic>Z</italic><sub>lr</sub> scores was observed for 5p14.1-q12.1, where the maximum <italic>Z</italic><sub>lr</sub> increased from 2.77 initially to 3.80 after fine mapping in the EA families.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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