Separating the mechanism-based and off-target actions of CETP-inhibitors using CETP gene polymorphisms
Identifieur interne : 002731 ( Pmc/Checkpoint ); précédent : 002730; suivant : 002732Separating the mechanism-based and off-target actions of CETP-inhibitors using CETP gene polymorphisms
Auteurs : Reecha Sofat [Royaume-Uni] ; Aroon D. Hingorani [Royaume-Uni] ; Liam Smeeth ; Steve E. Humphries ; Philippa J. Talmud ; Jackie Cooper ; Tina Shah [Royaume-Uni] ; Manjinder S. Sandhu [Royaume-Uni] ; Sally L. Ricketts [Royaume-Uni] ; S Matthijs Boekholdt [Royaume-Uni] ; Nicholas Wareham ; Kay Tee Khaw [Royaume-Uni] ; Meena Kumari [Royaume-Uni] ; Mika Kivimaki [Royaume-Uni] ; Michael Marmot [Royaume-Uni] ; Folkert W. Asselbergs [Pays-Bas] ; Pim Van Der Harst [Pays-Bas] ; Robin P F. Dullaart [Pays-Bas] ; Gerjan Navis [Pays-Bas] ; Dirk J. Van Veldhuisen [Pays-Bas] ; Wiek H. Van Gilst [Pays-Bas] ; John F. Thompson [États-Unis] ; Pamela Mccaskie ; Lyle J. Palmer ; Marcello Arca ; Fabiana Quagliarini ; Carlo Gaudio ; François Cambien [France] ; Viviane Nicaud [France] ; Odette Poirer [France] ; Vilmundur Gudnason [Islande] ; Aaron Isaacs [Pays-Bas] ; Jacqueline C M. Witteman [Pays-Bas] ; Cornelia M. Van Duijn [Pays-Bas] ; Michael Pencina ; Ramachandran. S. Vasan ; Ralph B. D'Agostino ; Jose Ordovas ; Tricia Y. Li [États-Unis] ; Sakari Kakko [Finlande] ; Heikki Kauma [Finlande] ; Markku J. Savolainen [Finlande] ; Y. Antero Kes Niemi [Finlande] ; Anton Sandhofer [Autriche] ; Bernhard Paulweber ; Jose V. Sorli ; Akimoto Goto [Japon] ; Shinji Yokoyama [Japon] ; Kenji Okumura [Japon] ; Benjamin D. Horne [États-Unis] ; Chris Packard ; Dilys Freeman ; Ian Ford [Royaume-Uni] ; Naveed Sattar [Royaume-Uni] ; Valerie Mccormack ; Debbie A. Lawlor [Royaume-Uni] ; Shah Ebrahim ; George Davey Smith [Royaume-Uni] ; John J P. Kastelein [Pays-Bas] ; John Deanfield [Royaume-Uni] ; Juan P. Casas [Royaume-Uni]Source :
- Circulation [ 0009-7322 ] ; 2009.
Abstract
Cholesteryl ester transfer protein (CETP) inhibitors raise HDL-cholesterol but torcetrapib, the first-in-class inhibitor tested in a large outcome trial caused unexpected blood pressure elevation and increased cardiovascular events. Whether the hypertensive effect resulted from CETP-inhibition or an off-target action of torcetrapib has been debated. We hypothesised that common single nucleotide polymorphisms (SNPs) in the
We compared the effect of
Discordance in the effects of
Url:
DOI: 10.1161/CIRCULATIONAHA.109.865444
PubMed: 20026784
PubMed Central: 2811869
Affiliations:
- Autriche, Finlande, France, Islande, Japon, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, Grand Londres, Groningue (province), Hollande-Méridionale, Massachusetts, Écosse, Île-de-France
- Cambridge, France, Glasgow, Groningue (ville), Londres, Rotterdam
- University College de Londres, Université de Cambridge, Université de Glasgow, Université de Groningue
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PMC:2811869Le document en format XML
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<author><name sortKey="Boekholdt, S Matthijs" sort="Boekholdt, S Matthijs" uniqKey="Boekholdt S" first="S Matthijs" last="Boekholdt">S Matthijs Boekholdt</name>
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<affiliation wicri:level="1"><nlm:aff id="A31"> MRC Centre of Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, UK</nlm:aff>
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<author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name>
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<affiliation><nlm:aff id="A17"> Boston University, Department of Mathematics and School of Medicine, Boston, Mass</nlm:aff>
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<author><name sortKey="Dullaart, Robin P F" sort="Dullaart, Robin P F" uniqKey="Dullaart R" first="Robin P F" last="Dullaart">Robin P F. Dullaart</name>
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<author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name>
<affiliation wicri:level="4"><nlm:aff id="A8"> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen</wicri:regionArea>
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<author><name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J" last="Van Veldhuisen">Dirk J. Van Veldhuisen</name>
<affiliation wicri:level="4"><nlm:aff id="A8"> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen</wicri:regionArea>
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<author><name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H" last="Van Gilst">Wiek H. Van Gilst</name>
<affiliation wicri:level="4"><nlm:aff id="A8"> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue (ville)</settlement>
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<author><name sortKey="Thompson, John F" sort="Thompson, John F" uniqKey="Thompson J" first="John F" last="Thompson">John F. Thompson</name>
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<country xml:lang="fr">États-Unis</country>
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</placeName>
<wicri:cityArea> Helicos BioSciences, One Kendall Square Bldg 700</wicri:cityArea>
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<author><name sortKey="Mccaskie, Pamela" sort="Mccaskie, Pamela" uniqKey="Mccaskie P" first="Pamela" last="Mccaskie">Pamela Mccaskie</name>
<affiliation><nlm:aff id="A10"> Centre for Genetic Epidemiology and Biostatistics, University of Western Australia</nlm:aff>
<wicri:noCountry code="subfield">University of Western Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name>
<affiliation><nlm:aff id="A10"> Centre for Genetic Epidemiology and Biostatistics, University of Western Australia</nlm:aff>
<wicri:noCountry code="subfield">University of Western Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Arca, Marcello" sort="Arca, Marcello" uniqKey="Arca M" first="Marcello" last="Arca">Marcello Arca</name>
<affiliation><nlm:aff id="A11"> Dipartimento di Clinica e Terapia Medica,La Sapienza Università di Roma</nlm:aff>
<wicri:noCountry code="subfield">a Sapienza Università di Roma</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Quagliarini, Fabiana" sort="Quagliarini, Fabiana" uniqKey="Quagliarini F" first="Fabiana" last="Quagliarini">Fabiana Quagliarini</name>
<affiliation><nlm:aff id="A11"> Dipartimento di Clinica e Terapia Medica,La Sapienza Università di Roma</nlm:aff>
<wicri:noCountry code="subfield">a Sapienza Università di Roma</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gaudio, Carlo" sort="Gaudio, Carlo" uniqKey="Gaudio C" first="Carlo" last="Gaudio">Carlo Gaudio</name>
<affiliation><nlm:aff id="A12"> Dipartimento Cuore e Grossi Vasi Attilio Reale, La Sapienza Università di Roma</nlm:aff>
<wicri:noCountry code="subfield">La Sapienza Università di Roma</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="François" last="Cambien">François Cambien</name>
<affiliation wicri:level="3"><nlm:aff id="A13"> INSERM, UMRS 937, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 937, Paris, F-75634 France</nlm:aff>
<country wicri:rule="zip">France</country>
<wicri:regionArea> INSERM, UMRS 937, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 937, Paris, F-75634 France</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
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<author><name sortKey="Nicaud, Viviane" sort="Nicaud, Viviane" uniqKey="Nicaud V" first="Viviane" last="Nicaud">Viviane Nicaud</name>
<affiliation wicri:level="3"><nlm:aff id="A13"> INSERM, UMRS 937, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 937, Paris, F-75634 France</nlm:aff>
<country wicri:rule="zip">France</country>
<wicri:regionArea> INSERM, UMRS 937, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 937, Paris, F-75634 France</wicri:regionArea>
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<author><name sortKey="Poirer, Odette" sort="Poirer, Odette" uniqKey="Poirer O" first="Odette" last="Poirer">Odette Poirer</name>
<affiliation wicri:level="3"><nlm:aff id="A14"> INSERM, UMRS 956, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 956, Paris, F-75634 France</nlm:aff>
<country wicri:rule="zip">France</country>
<wicri:regionArea> INSERM, UMRS 956, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 956, Paris, F-75634 France</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">France</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1"><nlm:aff id="A15"> University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea> University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name>
<affiliation wicri:level="3"><nlm:aff id="A16"> Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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<author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C M" last="Witteman">Jacqueline C M. Witteman</name>
<affiliation wicri:level="3"><nlm:aff id="A16"> Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="A16"> Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pencina, Michael" sort="Pencina, Michael" uniqKey="Pencina M" first="Michael" last="Pencina">Michael Pencina</name>
<affiliation><nlm:aff id="A17"> Boston University, Department of Mathematics and School of Medicine, Boston, Mass</nlm:aff>
<wicri:noCountry code="subfield">Mass</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vasan, Ramachandran S" sort="Vasan, Ramachandran S" uniqKey="Vasan R" first="Ramachandran. S" last="Vasan">Ramachandran. S. Vasan</name>
<affiliation><nlm:aff id="A17"> Boston University, Department of Mathematics and School of Medicine, Boston, Mass</nlm:aff>
<wicri:noCountry code="subfield">Mass</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="D Agostino, Ralph B" sort="D Agostino, Ralph B" uniqKey="D Agostino R" first="Ralph B" last="D'Agostino">Ralph B. D'Agostino</name>
<affiliation><nlm:aff id="A17"> Boston University, Department of Mathematics and School of Medicine, Boston, Mass</nlm:aff>
<wicri:noCountry code="subfield">Mass</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ordovas, Jose" sort="Ordovas, Jose" uniqKey="Ordovas J" first="Jose" last="Ordovas">Jose Ordovas</name>
<affiliation><nlm:aff id="A17"> Boston University, Department of Mathematics and School of Medicine, Boston, Mass</nlm:aff>
<wicri:noCountry code="subfield">Mass</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Li, Tricia Y" sort="Li, Tricia Y" uniqKey="Li T" first="Tricia Y." last="Li">Tricia Y. Li</name>
<affiliation wicri:level="2"><nlm:aff id="A18"> Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea> Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kakko, Sakari" sort="Kakko, Sakari" uniqKey="Kakko S" first="Sakari" last="Kakko">Sakari Kakko</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kauma, Heikki" sort="Kauma, Heikki" uniqKey="Kauma H" first="Heikki" last="Kauma">Heikki Kauma</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Savolainen, Markku J" sort="Savolainen, Markku J" uniqKey="Savolainen M" first="Markku J." last="Savolainen">Markku J. Savolainen</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y. Antero" last="Kes Niemi">Y. Antero Kes Niemi</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sandhofer, Anton" sort="Sandhofer, Anton" uniqKey="Sandhofer A" first="Anton" last="Sandhofer">Anton Sandhofer</name>
<affiliation wicri:level="1"><nlm:aff id="A20"> Department of Internal Medicine I, Medical University Innsbruck, Innsbruck, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea> Department of Internal Medicine I, Medical University Innsbruck, Innsbruck</wicri:regionArea>
<wicri:noRegion>Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name>
<affiliation><nlm:aff id="A21"> Department of Internal Medicine, Clinical Division of General Internal Medicine, University of Innsbruck Austria/ Department of Internal Medicine, Paracelsus Medical University, Salzburg Austria</nlm:aff>
<wicri:noCountry code="subfield">Salzburg Austria</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sorli, Jose V" sort="Sorli, Jose V" uniqKey="Sorli J" first="Jose V" last="Sorli">Jose V. Sorli</name>
<affiliation><nlm:aff id="A22"> Preventive Medicine Department, University of Valencia, Spain and CIBER Fisiopatologia de la Obesidad y Nutricion (ISCIII)</nlm:aff>
<wicri:noCountry code="subfield">Spain and CIBER Fisiopatologia de la Obesidad y Nutricion (ISCIII)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Goto, Akimoto" sort="Goto, Akimoto" uniqKey="Goto A" first="Akimoto" last="Goto">Akimoto Goto</name>
<affiliation wicri:level="1"><nlm:aff id="A23"> Cardiovascular Division, JA Aichi Bisai Hospital, Sobuecho, Inazawa 495-8531, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea> Cardiovascular Division, JA Aichi Bisai Hospital, Sobuecho, Inazawa 495-8531</wicri:regionArea>
<wicri:noRegion>Inazawa 495-8531</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yokoyama, Shinji" sort="Yokoyama, Shinji" uniqKey="Yokoyama S" first="Shinji" last="Yokoyama">Shinji Yokoyama</name>
<affiliation wicri:level="1"><nlm:aff id="A24"> Biochemistry, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea> Biochemistry, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601</wicri:regionArea>
<wicri:noRegion>Nagoya 467-8601</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Okumura, Kenji" sort="Okumura, Kenji" uniqKey="Okumura K" first="Kenji" last="Okumura">Kenji Okumura</name>
<affiliation wicri:level="1"><nlm:aff id="A25"> Cardiovascular Research Medicine, Nagoya University School of Medicine 65 Tsurumai-cho, Showa-ku, Nagoya, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea> Cardiovascular Research Medicine, Nagoya University School of Medicine 65 Tsurumai-cho, Showa-ku, Nagoya</wicri:regionArea>
<wicri:noRegion>Nagoya</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Horne, Benjamin D" sort="Horne, Benjamin D" uniqKey="Horne B" first="Benjamin D" last="Horne">Benjamin D. Horne</name>
<affiliation wicri:level="1"><nlm:aff id="A26"> Cardiovascular Department, Intermountain Medical Centre/ Department of Biomedical Informatics, University of Utah, Murray, Utah 84157, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Cardiovascular Department, Intermountain Medical Centre/ Department of Biomedical Informatics, University of Utah, Murray, Utah 84157</wicri:regionArea>
<wicri:noRegion>Utah 84157</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Packard, Chris" sort="Packard, Chris" uniqKey="Packard C" first="Chris" last="Packard">Chris Packard</name>
<affiliation><nlm:aff id="A27"> Glasgow Royal Infirmary, Glasgow G31 2ER</nlm:aff>
<wicri:noCountry code="subfield">Glasgow G31 2ER</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Freeman, Dilys" sort="Freeman, Dilys" uniqKey="Freeman D" first="Dilys" last="Freeman">Dilys Freeman</name>
<affiliation><nlm:aff id="A27"> Glasgow Royal Infirmary, Glasgow G31 2ER</nlm:aff>
<wicri:noCountry code="subfield">Glasgow G31 2ER</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation wicri:level="4"><nlm:aff id="A28"> Robertson Centre for Biostatistics, University of Glasgow</nlm:aff>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<affiliation wicri:level="4"><nlm:aff id="A29"> Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow</nlm:aff>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Mccormack, Valerie" sort="Mccormack, Valerie" uniqKey="Mccormack V" first="Valerie" last="Mccormack">Valerie Mccormack</name>
<affiliation><nlm:aff id="A3"> Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT</nlm:aff>
<wicri:noCountry code="subfield">London WC1E 7HT</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A30"> Lifestyle and Cancer Group, International Agency for Research on Cancer, 150 cours Albert Thomas,Lyon 69008 France</nlm:aff>
<wicri:noCountry code="subfield">yon 69008 France</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name>
<affiliation wicri:level="1"><nlm:aff id="A31"> MRC Centre of Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> MRC Centre of Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol</wicri:regionArea>
<wicri:noRegion>University of Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ebrahim, Shah" sort="Ebrahim, Shah" uniqKey="Ebrahim S" first="Shah" last="Ebrahim">Shah Ebrahim</name>
<affiliation><nlm:aff id="A3"> Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT</nlm:aff>
<wicri:noCountry code="subfield">London WC1E 7HT</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey Smith">George Davey Smith</name>
<affiliation wicri:level="1"><nlm:aff id="A31"> MRC Centre of Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> MRC Centre of Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol</wicri:regionArea>
<wicri:noRegion>University of Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J P" last="Kastelein">John J P. Kastelein</name>
<affiliation wicri:level="1"><nlm:aff id="A32"> Department of Vascular Medicine, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Vascular Medicine, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deanfield, John" sort="Deanfield, John" uniqKey="Deanfield J" first="John" last="Deanfield">John Deanfield</name>
<affiliation wicri:level="3"><nlm:aff id="A33"> Vascular Physiology Unit, UCL Institute of Child Health, London</nlm:aff>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<wicri:orgArea> Vascular Physiology Unit, UCL Institute of Child Health</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Casas, Juan P" sort="Casas, Juan P" uniqKey="Casas J" first="Juan P" last="Casas">Juan P. Casas</name>
<affiliation wicri:level="4"><nlm:aff id="A2"> Department of Epidemiology and Public Health, 1-19 Torrington Place, University College London, WC1E 6BT</nlm:aff>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A3"> Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT</nlm:aff>
<wicri:noCountry code="subfield">London WC1E 7HT</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
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<idno type="pmid">20026784</idno>
<idno type="pmc">2811869</idno>
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<idno type="RBID">PMC:2811869</idno>
<idno type="doi">10.1161/CIRCULATIONAHA.109.865444</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Separating the mechanism-based and off-target actions of CETP-inhibitors using <italic>CETP</italic>
gene polymorphisms</title>
<author><name sortKey="Sofat, Reecha" sort="Sofat, Reecha" uniqKey="Sofat R" first="Reecha" last="Sofat">Reecha Sofat</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Centre for Clinical Pharmacology, Department of Medicine, University College London, Rayne Building, 5 University Street, London, WC1E 6JF</nlm:aff>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Centre for Clinical Pharmacology, Department of Medicine, University College London, Rayne Building, 5 University Street, London, WC1E 6JF</nlm:aff>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2"> Department of Epidemiology and Public Health, 1-19 Torrington Place, University College London, WC1E 6BT</nlm:aff>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smeeth, Liam" sort="Smeeth, Liam" uniqKey="Smeeth L" first="Liam" last="Smeeth">Liam Smeeth</name>
<affiliation><nlm:aff id="A3"> Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT</nlm:aff>
<wicri:noCountry code="subfield">London WC1E 7HT</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name>
<affiliation><nlm:aff id="A4"> Centre for Cardiovascular Genetics, University College London Rayne Building, 5 University Street, London, WC1E 6JF</nlm:aff>
<wicri:noCountry code="subfield">WC1E 6JF</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Talmud, Philippa J" sort="Talmud, Philippa J" uniqKey="Talmud P" first="Philippa J" last="Talmud">Philippa J. Talmud</name>
<affiliation><nlm:aff id="A4"> Centre for Cardiovascular Genetics, University College London Rayne Building, 5 University Street, London, WC1E 6JF</nlm:aff>
<wicri:noCountry code="subfield">WC1E 6JF</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cooper, Jackie" sort="Cooper, Jackie" uniqKey="Cooper J" first="Jackie" last="Cooper">Jackie Cooper</name>
<affiliation><nlm:aff id="A4"> Centre for Cardiovascular Genetics, University College London Rayne Building, 5 University Street, London, WC1E 6JF</nlm:aff>
<wicri:noCountry code="subfield">WC1E 6JF</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shah, Tina" sort="Shah, Tina" uniqKey="Shah T" first="Tina" last="Shah">Tina Shah</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Centre for Clinical Pharmacology, Department of Medicine, University College London, Rayne Building, 5 University Street, London, WC1E 6JF</nlm:aff>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sandhu, Manjinder S" sort="Sandhu, Manjinder S" uniqKey="Sandhu M" first="Manjinder S" last="Sandhu">Manjinder S. Sandhu</name>
<affiliation wicri:level="4"><nlm:aff id="A5"> Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge</nlm:aff>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
<orgName type="university">Université de Cambridge</orgName>
</affiliation>
</author>
<author><name sortKey="Ricketts, Sally L" sort="Ricketts, Sally L" uniqKey="Ricketts S" first="Sally L" last="Ricketts">Sally L. Ricketts</name>
<affiliation wicri:level="4"><nlm:aff id="A5"> Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge</nlm:aff>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
<orgName type="university">Université de Cambridge</orgName>
</affiliation>
</author>
<author><name sortKey="Boekholdt, S Matthijs" sort="Boekholdt, S Matthijs" uniqKey="Boekholdt S" first="S Matthijs" last="Boekholdt">S Matthijs Boekholdt</name>
<affiliation wicri:level="4"><nlm:aff id="A5"> Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge</nlm:aff>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
<orgName type="university">Université de Cambridge</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A31"> MRC Centre of Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> MRC Centre of Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol</wicri:regionArea>
<wicri:noRegion>University of Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wareham, Nicholas" sort="Wareham, Nicholas" uniqKey="Wareham N" first="Nicholas" last="Wareham">Nicholas Wareham</name>
<affiliation><nlm:aff id="A6"> MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge UK</nlm:aff>
<wicri:noCountry code="subfield">Cambridge UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay Tee" last="Khaw">Kay Tee Khaw</name>
<affiliation wicri:level="4"><nlm:aff id="A7"> Department of Clinical Gerontology. University of Cambridge, Addenbrooke's Hospital, Cambridge UK</nlm:aff>
<orgName type="university">Université de Cambridge</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name>
<affiliation wicri:level="4"><nlm:aff id="A2"> Department of Epidemiology and Public Health, 1-19 Torrington Place, University College London, WC1E 6BT</nlm:aff>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name>
<affiliation wicri:level="4"><nlm:aff id="A2"> Department of Epidemiology and Public Health, 1-19 Torrington Place, University College London, WC1E 6BT</nlm:aff>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marmot, Michael" sort="Marmot, Michael" uniqKey="Marmot M" first="Michael" last="Marmot">Michael Marmot</name>
<affiliation wicri:level="4"><nlm:aff id="A2"> Department of Epidemiology and Public Health, 1-19 Torrington Place, University College London, WC1E 6BT</nlm:aff>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name>
<affiliation wicri:level="4"><nlm:aff id="A8"> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
<affiliation><nlm:aff id="A17"> Boston University, Department of Mathematics and School of Medicine, Boston, Mass</nlm:aff>
<wicri:noCountry code="subfield">Mass</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name>
<affiliation wicri:level="4"><nlm:aff id="A8"> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author><name sortKey="Dullaart, Robin P F" sort="Dullaart, Robin P F" uniqKey="Dullaart R" first="Robin P F" last="Dullaart">Robin P F. Dullaart</name>
<affiliation wicri:level="4"><nlm:aff id="A8"> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name>
<affiliation wicri:level="4"><nlm:aff id="A8"> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author><name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J" last="Van Veldhuisen">Dirk J. Van Veldhuisen</name>
<affiliation wicri:level="4"><nlm:aff id="A8"> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author><name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H" last="Van Gilst">Wiek H. Van Gilst</name>
<affiliation wicri:level="4"><nlm:aff id="A8"> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author><name sortKey="Thompson, John F" sort="Thompson, John F" uniqKey="Thompson J" first="John F" last="Thompson">John F. Thompson</name>
<affiliation wicri:level="2"><nlm:aff id="A9"> Helicos BioSciences, One Kendall Square Bldg 700, Cambridge MA 02139 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea> Helicos BioSciences, One Kendall Square Bldg 700</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mccaskie, Pamela" sort="Mccaskie, Pamela" uniqKey="Mccaskie P" first="Pamela" last="Mccaskie">Pamela Mccaskie</name>
<affiliation><nlm:aff id="A10"> Centre for Genetic Epidemiology and Biostatistics, University of Western Australia</nlm:aff>
<wicri:noCountry code="subfield">University of Western Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name>
<affiliation><nlm:aff id="A10"> Centre for Genetic Epidemiology and Biostatistics, University of Western Australia</nlm:aff>
<wicri:noCountry code="subfield">University of Western Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Arca, Marcello" sort="Arca, Marcello" uniqKey="Arca M" first="Marcello" last="Arca">Marcello Arca</name>
<affiliation><nlm:aff id="A11"> Dipartimento di Clinica e Terapia Medica,La Sapienza Università di Roma</nlm:aff>
<wicri:noCountry code="subfield">a Sapienza Università di Roma</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Quagliarini, Fabiana" sort="Quagliarini, Fabiana" uniqKey="Quagliarini F" first="Fabiana" last="Quagliarini">Fabiana Quagliarini</name>
<affiliation><nlm:aff id="A11"> Dipartimento di Clinica e Terapia Medica,La Sapienza Università di Roma</nlm:aff>
<wicri:noCountry code="subfield">a Sapienza Università di Roma</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gaudio, Carlo" sort="Gaudio, Carlo" uniqKey="Gaudio C" first="Carlo" last="Gaudio">Carlo Gaudio</name>
<affiliation><nlm:aff id="A12"> Dipartimento Cuore e Grossi Vasi Attilio Reale, La Sapienza Università di Roma</nlm:aff>
<wicri:noCountry code="subfield">La Sapienza Università di Roma</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="François" last="Cambien">François Cambien</name>
<affiliation wicri:level="3"><nlm:aff id="A13"> INSERM, UMRS 937, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 937, Paris, F-75634 France</nlm:aff>
<country wicri:rule="zip">France</country>
<wicri:regionArea> INSERM, UMRS 937, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 937, Paris, F-75634 France</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">France</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nicaud, Viviane" sort="Nicaud, Viviane" uniqKey="Nicaud V" first="Viviane" last="Nicaud">Viviane Nicaud</name>
<affiliation wicri:level="3"><nlm:aff id="A13"> INSERM, UMRS 937, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 937, Paris, F-75634 France</nlm:aff>
<country wicri:rule="zip">France</country>
<wicri:regionArea> INSERM, UMRS 937, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 937, Paris, F-75634 France</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">France</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poirer, Odette" sort="Poirer, Odette" uniqKey="Poirer O" first="Odette" last="Poirer">Odette Poirer</name>
<affiliation wicri:level="3"><nlm:aff id="A14"> INSERM, UMRS 956, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 956, Paris, F-75634 France</nlm:aff>
<country wicri:rule="zip">France</country>
<wicri:regionArea> INSERM, UMRS 956, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 956, Paris, F-75634 France</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">France</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1"><nlm:aff id="A15"> University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea> University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name>
<affiliation wicri:level="3"><nlm:aff id="A16"> Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C M" last="Witteman">Jacqueline C M. Witteman</name>
<affiliation wicri:level="3"><nlm:aff id="A16"> Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="A16"> Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pencina, Michael" sort="Pencina, Michael" uniqKey="Pencina M" first="Michael" last="Pencina">Michael Pencina</name>
<affiliation><nlm:aff id="A17"> Boston University, Department of Mathematics and School of Medicine, Boston, Mass</nlm:aff>
<wicri:noCountry code="subfield">Mass</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vasan, Ramachandran S" sort="Vasan, Ramachandran S" uniqKey="Vasan R" first="Ramachandran. S" last="Vasan">Ramachandran. S. Vasan</name>
<affiliation><nlm:aff id="A17"> Boston University, Department of Mathematics and School of Medicine, Boston, Mass</nlm:aff>
<wicri:noCountry code="subfield">Mass</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="D Agostino, Ralph B" sort="D Agostino, Ralph B" uniqKey="D Agostino R" first="Ralph B" last="D'Agostino">Ralph B. D'Agostino</name>
<affiliation><nlm:aff id="A17"> Boston University, Department of Mathematics and School of Medicine, Boston, Mass</nlm:aff>
<wicri:noCountry code="subfield">Mass</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ordovas, Jose" sort="Ordovas, Jose" uniqKey="Ordovas J" first="Jose" last="Ordovas">Jose Ordovas</name>
<affiliation><nlm:aff id="A17"> Boston University, Department of Mathematics and School of Medicine, Boston, Mass</nlm:aff>
<wicri:noCountry code="subfield">Mass</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Li, Tricia Y" sort="Li, Tricia Y" uniqKey="Li T" first="Tricia Y." last="Li">Tricia Y. Li</name>
<affiliation wicri:level="2"><nlm:aff id="A18"> Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea> Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kakko, Sakari" sort="Kakko, Sakari" uniqKey="Kakko S" first="Sakari" last="Kakko">Sakari Kakko</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kauma, Heikki" sort="Kauma, Heikki" uniqKey="Kauma H" first="Heikki" last="Kauma">Heikki Kauma</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Savolainen, Markku J" sort="Savolainen, Markku J" uniqKey="Savolainen M" first="Markku J." last="Savolainen">Markku J. Savolainen</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y. Antero" last="Kes Niemi">Y. Antero Kes Niemi</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sandhofer, Anton" sort="Sandhofer, Anton" uniqKey="Sandhofer A" first="Anton" last="Sandhofer">Anton Sandhofer</name>
<affiliation wicri:level="1"><nlm:aff id="A20"> Department of Internal Medicine I, Medical University Innsbruck, Innsbruck, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea> Department of Internal Medicine I, Medical University Innsbruck, Innsbruck</wicri:regionArea>
<wicri:noRegion>Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name>
<affiliation><nlm:aff id="A21"> Department of Internal Medicine, Clinical Division of General Internal Medicine, University of Innsbruck Austria/ Department of Internal Medicine, Paracelsus Medical University, Salzburg Austria</nlm:aff>
<wicri:noCountry code="subfield">Salzburg Austria</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sorli, Jose V" sort="Sorli, Jose V" uniqKey="Sorli J" first="Jose V" last="Sorli">Jose V. Sorli</name>
<affiliation><nlm:aff id="A22"> Preventive Medicine Department, University of Valencia, Spain and CIBER Fisiopatologia de la Obesidad y Nutricion (ISCIII)</nlm:aff>
<wicri:noCountry code="subfield">Spain and CIBER Fisiopatologia de la Obesidad y Nutricion (ISCIII)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Goto, Akimoto" sort="Goto, Akimoto" uniqKey="Goto A" first="Akimoto" last="Goto">Akimoto Goto</name>
<affiliation wicri:level="1"><nlm:aff id="A23"> Cardiovascular Division, JA Aichi Bisai Hospital, Sobuecho, Inazawa 495-8531, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea> Cardiovascular Division, JA Aichi Bisai Hospital, Sobuecho, Inazawa 495-8531</wicri:regionArea>
<wicri:noRegion>Inazawa 495-8531</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yokoyama, Shinji" sort="Yokoyama, Shinji" uniqKey="Yokoyama S" first="Shinji" last="Yokoyama">Shinji Yokoyama</name>
<affiliation wicri:level="1"><nlm:aff id="A24"> Biochemistry, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea> Biochemistry, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601</wicri:regionArea>
<wicri:noRegion>Nagoya 467-8601</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Okumura, Kenji" sort="Okumura, Kenji" uniqKey="Okumura K" first="Kenji" last="Okumura">Kenji Okumura</name>
<affiliation wicri:level="1"><nlm:aff id="A25"> Cardiovascular Research Medicine, Nagoya University School of Medicine 65 Tsurumai-cho, Showa-ku, Nagoya, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea> Cardiovascular Research Medicine, Nagoya University School of Medicine 65 Tsurumai-cho, Showa-ku, Nagoya</wicri:regionArea>
<wicri:noRegion>Nagoya</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Horne, Benjamin D" sort="Horne, Benjamin D" uniqKey="Horne B" first="Benjamin D" last="Horne">Benjamin D. Horne</name>
<affiliation wicri:level="1"><nlm:aff id="A26"> Cardiovascular Department, Intermountain Medical Centre/ Department of Biomedical Informatics, University of Utah, Murray, Utah 84157, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Cardiovascular Department, Intermountain Medical Centre/ Department of Biomedical Informatics, University of Utah, Murray, Utah 84157</wicri:regionArea>
<wicri:noRegion>Utah 84157</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Packard, Chris" sort="Packard, Chris" uniqKey="Packard C" first="Chris" last="Packard">Chris Packard</name>
<affiliation><nlm:aff id="A27"> Glasgow Royal Infirmary, Glasgow G31 2ER</nlm:aff>
<wicri:noCountry code="subfield">Glasgow G31 2ER</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Freeman, Dilys" sort="Freeman, Dilys" uniqKey="Freeman D" first="Dilys" last="Freeman">Dilys Freeman</name>
<affiliation><nlm:aff id="A27"> Glasgow Royal Infirmary, Glasgow G31 2ER</nlm:aff>
<wicri:noCountry code="subfield">Glasgow G31 2ER</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation wicri:level="4"><nlm:aff id="A28"> Robertson Centre for Biostatistics, University of Glasgow</nlm:aff>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<affiliation wicri:level="4"><nlm:aff id="A29"> Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow</nlm:aff>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Mccormack, Valerie" sort="Mccormack, Valerie" uniqKey="Mccormack V" first="Valerie" last="Mccormack">Valerie Mccormack</name>
<affiliation><nlm:aff id="A3"> Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT</nlm:aff>
<wicri:noCountry code="subfield">London WC1E 7HT</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A30"> Lifestyle and Cancer Group, International Agency for Research on Cancer, 150 cours Albert Thomas,Lyon 69008 France</nlm:aff>
<wicri:noCountry code="subfield">yon 69008 France</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name>
<affiliation wicri:level="1"><nlm:aff id="A31"> MRC Centre of Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> MRC Centre of Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol</wicri:regionArea>
<wicri:noRegion>University of Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ebrahim, Shah" sort="Ebrahim, Shah" uniqKey="Ebrahim S" first="Shah" last="Ebrahim">Shah Ebrahim</name>
<affiliation><nlm:aff id="A3"> Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT</nlm:aff>
<wicri:noCountry code="subfield">London WC1E 7HT</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey Smith">George Davey Smith</name>
<affiliation wicri:level="1"><nlm:aff id="A31"> MRC Centre of Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> MRC Centre of Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol</wicri:regionArea>
<wicri:noRegion>University of Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J P" last="Kastelein">John J P. Kastelein</name>
<affiliation wicri:level="1"><nlm:aff id="A32"> Department of Vascular Medicine, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Vascular Medicine, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deanfield, John" sort="Deanfield, John" uniqKey="Deanfield J" first="John" last="Deanfield">John Deanfield</name>
<affiliation wicri:level="3"><nlm:aff id="A33"> Vascular Physiology Unit, UCL Institute of Child Health, London</nlm:aff>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<wicri:orgArea> Vascular Physiology Unit, UCL Institute of Child Health</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Casas, Juan P" sort="Casas, Juan P" uniqKey="Casas J" first="Juan P" last="Casas">Juan P. Casas</name>
<affiliation wicri:level="4"><nlm:aff id="A2"> Department of Epidemiology and Public Health, 1-19 Torrington Place, University College London, WC1E 6BT</nlm:aff>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A3"> Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT</nlm:aff>
<wicri:noCountry code="subfield">London WC1E 7HT</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Circulation</title>
<idno type="ISSN">0009-7322</idno>
<idno type="eISSN">1524-4539</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background:</title>
<p id="P2">Cholesteryl ester transfer protein (CETP) inhibitors raise HDL-cholesterol but torcetrapib, the first-in-class inhibitor tested in a large outcome trial caused unexpected blood pressure elevation and increased cardiovascular events. Whether the hypertensive effect resulted from CETP-inhibition or an off-target action of torcetrapib has been debated. We hypothesised that common single nucleotide polymorphisms (SNPs) in the <italic>CETP-</italic>
gene could help distinguish mechanism-based from off-target actions of CETP-inhibitors to inform on the validity of CETP as a therapeutic target.</p>
</sec>
<sec id="S2"><title>Methods and Results</title>
<p id="P3">We compared the effect of <italic>CETP</italic>
SNPs and torcetrapib treatment on lipid fractions, blood pressure and electrolytes in up to 67,687 individuals from genetic studies and 17,911 from randomised trials. <italic>CETP</italic>
SNPs <italic>and</italic>
torcetrapib treatment reduced CETP activity and had directionally concordant effect on eight lipid and lipoprotein traits (total-, LDL- and HDL-cholesterol, HDL2, HDL3, apolipoproteins A-I, -B, and triglycerides), with the genetic effect on HDL-cholesterol (0.13 mmol/L; 95% CI: 0.11, 0.14) being consistent with that expected of a 10 mg dose of torcetrapib (0.13 mmol/L; 0.10, 0.15). In trials, 60mg torcetrapib elevated systolic and diastolic blood pressure by 4.47mmHg (4.10, 4.84) and 2.08mmHg (1.84, 2.31) respectively. However, the effect of CETP SNPs on systolic 0.16mmHg (−0.28, 0.60) and diastolic blood pressure −0.04mmHg (−0.36, 0.28) was null and significantly different from that expected of 10 mg torcetrapib.</p>
</sec>
<sec id="S3"><title>Conclusions:</title>
<p id="P4">Discordance in the effects of <italic>CETP</italic>
SNPs and torcetrapib treatment on blood pressure despite the concordant effects on lipids indicates the hypertensive action of torcetrapib is unlikely to be due to CETP-inhibition, or shared by chemically dissimilar CETP inhibitors. Genetic studies could find use in drug development programmes as a new source of randomised evidence for drug target validation in man.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0147763</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2979</journal-id>
<journal-id journal-id-type="nlm-ta">Circulation</journal-id>
<journal-id journal-id-type="iso-abbrev">Circulation</journal-id>
<journal-title-group><journal-title>Circulation</journal-title>
</journal-title-group>
<issn pub-type="ppub">0009-7322</issn>
<issn pub-type="epub">1524-4539</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20026784</article-id>
<article-id pub-id-type="pmc">2811869</article-id>
<article-id pub-id-type="doi">10.1161/CIRCULATIONAHA.109.865444</article-id>
<article-id pub-id-type="manuscript">UKMS28287</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Separating the mechanism-based and off-target actions of CETP-inhibitors using <italic>CETP</italic>
gene polymorphisms</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Sofat</surname>
<given-names>Reecha</given-names>
</name>
<degrees>MRCP</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="author-notes" rid="FN1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hingorani</surname>
<given-names>Aroon D</given-names>
</name>
<degrees>PhD, FRCP</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="author-notes" rid="FN1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smeeth</surname>
<given-names>Liam</given-names>
</name>
<degrees>MRCGP, PhD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
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<given-names>Steve E</given-names>
</name>
<degrees>PhD, MRCP, FRCPath</degrees>
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</contrib>
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<given-names>Philippa J</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
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<given-names>Jackie</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shah</surname>
<given-names>Tina</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
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<given-names>Manjinder S</given-names>
</name>
<degrees>PhD</degrees>
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<given-names>Sally L</given-names>
</name>
<degrees>PhD</degrees>
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</contrib>
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<given-names>S Matthijs</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="aff" rid="A31">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wareham</surname>
<given-names>Nicholas</given-names>
</name>
<degrees>MBBS FRCP</degrees>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Khaw</surname>
<given-names>Kay Tee</given-names>
</name>
<degrees>MBBChir, FRCP</degrees>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
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<given-names>Meena</given-names>
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<degrees>PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
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<given-names>Mika</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Marmot</surname>
<given-names>Michael</given-names>
</name>
<degrees>PhD, FRCP</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
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<given-names>Folkert W</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van der Harst</surname>
<given-names>Pim</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dullaart</surname>
<given-names>Robin P F</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Navis</surname>
<given-names>Gerjan</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Veldhuisen</surname>
<given-names>Dirk J</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Van Gilst</surname>
<given-names>Wiek H</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
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<given-names>John F</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McCaskie</surname>
<given-names>Pamela</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Palmer</surname>
<given-names>Lyle J</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arca</surname>
<given-names>Marcello</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Quagliarini</surname>
<given-names>Fabiana</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gaudio</surname>
<given-names>Carlo</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cambien</surname>
<given-names>François</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nicaud</surname>
<given-names>Viviane</given-names>
</name>
<degrees>MA</degrees>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Poirer</surname>
<given-names>Odette</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gudnason</surname>
<given-names>Vilmundur</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Isaacs</surname>
<given-names>Aaron</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A16">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Witteman</surname>
<given-names>Jacqueline C M</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A16">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Duijn</surname>
<given-names>Cornelia M</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A16">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pencina</surname>
<given-names>Michael</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vasan</surname>
<given-names>Ramachandran. S</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>D'Agostino</surname>
<given-names>Ralph B</given-names>
<suffix>Sr</suffix>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ordovas</surname>
<given-names>Jose</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Tricia Y.</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="A18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kakko</surname>
<given-names>Sakari</given-names>
</name>
<degrees>MD PhD</degrees>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kauma</surname>
<given-names>Heikki</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Savolainen</surname>
<given-names>Markku J.</given-names>
</name>
<degrees>MD PhD</degrees>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kesäniemi</surname>
<given-names>Y.Antero</given-names>
</name>
<degrees>MD, PhD, FAHA</degrees>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sandhofer</surname>
<given-names>Anton</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Paulweber</surname>
<given-names>Bernhard</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A21">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sorli</surname>
<given-names>Jose V</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Goto</surname>
<given-names>Akimoto</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yokoyama</surname>
<given-names>Shinji</given-names>
</name>
<degrees>MD, PhD, FRCPC</degrees>
<xref ref-type="aff" rid="A24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Okumura</surname>
<given-names>Kenji</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A25">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Horne</surname>
<given-names>Benjamin D</given-names>
</name>
<degrees>PhD, MPH</degrees>
<xref ref-type="aff" rid="A26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Packard</surname>
<given-names>Chris</given-names>
</name>
<degrees>DSc</degrees>
<xref ref-type="aff" rid="A27">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Freeman</surname>
<given-names>Dilys</given-names>
</name>
<degrees>BSc, PhD</degrees>
<xref ref-type="aff" rid="A27">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ford</surname>
<given-names>Ian</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sattar</surname>
<given-names>Naveed</given-names>
</name>
<degrees>PhD, FRCPath</degrees>
<xref ref-type="aff" rid="A29">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McCormack</surname>
<given-names>Valerie</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A30">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lawlor</surname>
<given-names>Debbie A</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A31">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ebrahim</surname>
<given-names>Shah</given-names>
</name>
<degrees>Dm, MSc, FFPHM</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Davey Smith</surname>
<given-names>George</given-names>
</name>
<degrees>MD, DSc, FFPHM</degrees>
<xref ref-type="aff" rid="A31">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kastelein</surname>
<given-names>John J P</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Deanfield</surname>
<given-names>John</given-names>
</name>
<degrees>BA, BCh, MB, FRCP</degrees>
<xref ref-type="aff" rid="A33">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Casas</surname>
<given-names>Juan P</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Centre for Clinical Pharmacology, Department of Medicine, University College London, Rayne Building, 5 University Street, London, WC1E 6JF</aff>
<aff id="A2"><label>2</label>
Department of Epidemiology and Public Health, 1-19 Torrington Place, University College London, WC1E 6BT</aff>
<aff id="A3"><label>3</label>
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT</aff>
<aff id="A4"><label>4</label>
Centre for Cardiovascular Genetics, University College London Rayne Building, 5 University Street, London, WC1E 6JF</aff>
<aff id="A5"><label>5</label>
Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge</aff>
<aff id="A6"><label>6</label>
MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge UK</aff>
<aff id="A7"><label>7</label>
Department of Clinical Gerontology. University of Cambridge, Addenbrooke's Hospital, Cambridge UK</aff>
<aff id="A8"><label>8</label>
Departments of Cardiology, Endocrinology, Nephrology University Medical Center Groningen, University of Groningen, The Netherlands</aff>
<aff id="A9"><label>9</label>
Helicos BioSciences, One Kendall Square Bldg 700, Cambridge MA 02139 USA</aff>
<aff id="A10"><label>10</label>
Centre for Genetic Epidemiology and Biostatistics, University of Western Australia</aff>
<aff id="A11"><label>11</label>
Dipartimento di Clinica e Terapia Medica,La Sapienza Università di Roma</aff>
<aff id="A12"><label>12</label>
Dipartimento Cuore e Grossi Vasi Attilio Reale, La Sapienza Università di Roma</aff>
<aff id="A13"><label>13</label>
INSERM, UMRS 937, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 937, Paris, F-75634 France</aff>
<aff id="A14"><label>14</label>
INSERM, UMRS 956, Paris, F-75634 France; Université Pierre et Marie Curie-Paris6, UMRS 956, Paris, F-75634 France</aff>
<aff id="A15"><label>15</label>
University of Iceland, Reykjavik, Iceland</aff>
<aff id="A16"><label>16</label>
Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands</aff>
<aff id="A17"><label>17</label>
Boston University, Department of Mathematics and School of Medicine, Boston, Mass</aff>
<aff id="A18"><label>18</label>
Department of Nutrition, Harvard School of Public Health, Boston, MA</aff>
<aff id="A19"><label>19</label>
Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland</aff>
<aff id="A20"><label>20</label>
Department of Internal Medicine I, Medical University Innsbruck, Innsbruck, Austria</aff>
<aff id="A21"><label>21</label>
Department of Internal Medicine, Clinical Division of General Internal Medicine, University of Innsbruck Austria/ Department of Internal Medicine, Paracelsus Medical University, Salzburg Austria</aff>
<aff id="A22"><label>22</label>
Preventive Medicine Department, University of Valencia, Spain and CIBER Fisiopatologia de la Obesidad y Nutricion (ISCIII)</aff>
<aff id="A23"><label>23</label>
Cardiovascular Division, JA Aichi Bisai Hospital, Sobuecho, Inazawa 495-8531, Japan</aff>
<aff id="A24"><label>24</label>
Biochemistry, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan</aff>
<aff id="A25"><label>25</label>
Cardiovascular Research Medicine, Nagoya University School of Medicine 65 Tsurumai-cho, Showa-ku, Nagoya, Japan</aff>
<aff id="A26"><label>26</label>
Cardiovascular Department, Intermountain Medical Centre/ Department of Biomedical Informatics, University of Utah, Murray, Utah 84157, USA</aff>
<aff id="A27"><label>27</label>
Glasgow Royal Infirmary, Glasgow G31 2ER</aff>
<aff id="A28"><label>28</label>
Robertson Centre for Biostatistics, University of Glasgow</aff>
<aff id="A29"><label>29</label>
Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow</aff>
<aff id="A30"><label>30</label>
Lifestyle and Cancer Group, International Agency for Research on Cancer, 150 cours Albert Thomas,Lyon 69008 France</aff>
<aff id="A31"><label>31</label>
MRC Centre of Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, UK</aff>
<aff id="A32"><label>32</label>
Department of Vascular Medicine, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands</aff>
<aff id="A33"><label>33</label>
Vascular Physiology Unit, UCL Institute of Child Health, London</aff>
<author-notes><corresp id="CR1"><bold>Name and Address for Correspondence:</bold>
Professor Aroon Hingorani, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT <bold>Fax Number:</bold>
+44(0)20 7679 6211, <bold>Telephone:</bold>
+44(0)20 7679 6612, <email>a.hingorani@ucl.ac.uk</email>
</corresp>
<corresp id="CR2">Dr Juan P Casas, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT <bold>Fax Number:</bold>
+(44) 207 580 6897 <bold>Telephone:</bold>
+(44) 207 927 2163 <email>Juan.Pablo-Casas@lshtm.ac.uk</email>
</corresp>
<fn fn-type="equal" id="FN1"><label>†</label>
<p id="P1">Contributed equally</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>6</day>
<month>1</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>21</day>
<month>12</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="ppub"><day>5</day>
<month>1</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>05</day>
<month>7</month>
<year>2010</year>
</pub-date>
<volume>121</volume>
<issue>1</issue>
<fpage>52</fpage>
<lpage>62</lpage>
<abstract><sec id="S1"><title>Background:</title>
<p id="P2">Cholesteryl ester transfer protein (CETP) inhibitors raise HDL-cholesterol but torcetrapib, the first-in-class inhibitor tested in a large outcome trial caused unexpected blood pressure elevation and increased cardiovascular events. Whether the hypertensive effect resulted from CETP-inhibition or an off-target action of torcetrapib has been debated. We hypothesised that common single nucleotide polymorphisms (SNPs) in the <italic>CETP-</italic>
gene could help distinguish mechanism-based from off-target actions of CETP-inhibitors to inform on the validity of CETP as a therapeutic target.</p>
</sec>
<sec id="S2"><title>Methods and Results</title>
<p id="P3">We compared the effect of <italic>CETP</italic>
SNPs and torcetrapib treatment on lipid fractions, blood pressure and electrolytes in up to 67,687 individuals from genetic studies and 17,911 from randomised trials. <italic>CETP</italic>
SNPs <italic>and</italic>
torcetrapib treatment reduced CETP activity and had directionally concordant effect on eight lipid and lipoprotein traits (total-, LDL- and HDL-cholesterol, HDL2, HDL3, apolipoproteins A-I, -B, and triglycerides), with the genetic effect on HDL-cholesterol (0.13 mmol/L; 95% CI: 0.11, 0.14) being consistent with that expected of a 10 mg dose of torcetrapib (0.13 mmol/L; 0.10, 0.15). In trials, 60mg torcetrapib elevated systolic and diastolic blood pressure by 4.47mmHg (4.10, 4.84) and 2.08mmHg (1.84, 2.31) respectively. However, the effect of CETP SNPs on systolic 0.16mmHg (−0.28, 0.60) and diastolic blood pressure −0.04mmHg (−0.36, 0.28) was null and significantly different from that expected of 10 mg torcetrapib.</p>
</sec>
<sec id="S3"><title>Conclusions:</title>
<p id="P4">Discordance in the effects of <italic>CETP</italic>
SNPs and torcetrapib treatment on blood pressure despite the concordant effects on lipids indicates the hypertensive action of torcetrapib is unlikely to be due to CETP-inhibition, or shared by chemically dissimilar CETP inhibitors. Genetic studies could find use in drug development programmes as a new source of randomised evidence for drug target validation in man.</p>
</sec>
</abstract>
<kwd-group><kwd>genetics</kwd>
<kwd>pharmacology</kwd>
<kwd>epidemiology</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source>
<award-id>082178 || WT</award-id>
</award-group>
<award-group><funding-source country="United Kingdom">Medical Research Council : </funding-source>
<award-id>G19/35(70654) || MRC_</award-id>
</award-group>
<award-group><funding-source country="United Kingdom">British Heart Foundation : </funding-source>
<award-id>PG/04/110/17827 || BHF_</award-id>
</award-group>
<award-group><funding-source country="United Kingdom">British Heart Foundation : </funding-source>
<award-id>FS/07/011/22085 || BHF_</award-id>
</award-group>
<award-group><funding-source country="United Kingdom">British Heart Foundation : </funding-source>
<award-id>FS/05/125/19379 || BHF_</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Autriche</li>
<li>Finlande</li>
<li>France</li>
<li>Islande</li>
<li>Japon</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Grand Londres</li>
<li>Groningue (province)</li>
<li>Hollande-Méridionale</li>
<li>Massachusetts</li>
<li>Écosse</li>
<li>Île-de-France</li>
</region>
<settlement><li>Cambridge</li>
<li>France</li>
<li>Glasgow</li>
<li>Groningue (ville)</li>
<li>Londres</li>
<li>Rotterdam</li>
</settlement>
<orgName><li>University College de Londres</li>
<li>Université de Cambridge</li>
<li>Université de Glasgow</li>
<li>Université de Groningue</li>
</orgName>
</list>
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<name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name>
<name sortKey="Mccaskie, Pamela" sort="Mccaskie, Pamela" uniqKey="Mccaskie P" first="Pamela" last="Mccaskie">Pamela Mccaskie</name>
<name sortKey="Mccormack, Valerie" sort="Mccormack, Valerie" uniqKey="Mccormack V" first="Valerie" last="Mccormack">Valerie Mccormack</name>
<name sortKey="Ordovas, Jose" sort="Ordovas, Jose" uniqKey="Ordovas J" first="Jose" last="Ordovas">Jose Ordovas</name>
<name sortKey="Packard, Chris" sort="Packard, Chris" uniqKey="Packard C" first="Chris" last="Packard">Chris Packard</name>
<name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name>
<name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name>
<name sortKey="Pencina, Michael" sort="Pencina, Michael" uniqKey="Pencina M" first="Michael" last="Pencina">Michael Pencina</name>
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<name sortKey="Wareham, Nicholas" sort="Wareham, Nicholas" uniqKey="Wareham N" first="Nicholas" last="Wareham">Nicholas Wareham</name>
</noCountry>
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</region>
<name sortKey="Boekholdt, S Matthijs" sort="Boekholdt, S Matthijs" uniqKey="Boekholdt S" first="S Matthijs" last="Boekholdt">S Matthijs Boekholdt</name>
<name sortKey="Boekholdt, S Matthijs" sort="Boekholdt, S Matthijs" uniqKey="Boekholdt S" first="S Matthijs" last="Boekholdt">S Matthijs Boekholdt</name>
<name sortKey="Casas, Juan P" sort="Casas, Juan P" uniqKey="Casas J" first="Juan P" last="Casas">Juan P. Casas</name>
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<name sortKey="Deanfield, John" sort="Deanfield, John" uniqKey="Deanfield J" first="John" last="Deanfield">John Deanfield</name>
<name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name>
<name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name>
<name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay Tee" last="Khaw">Kay Tee Khaw</name>
<name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name>
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<name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name>
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<name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<name sortKey="Shah, Tina" sort="Shah, Tina" uniqKey="Shah T" first="Tina" last="Shah">Tina Shah</name>
</country>
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<name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J P" last="Kastelein">John J P. Kastelein</name>
<name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name>
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<name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J" last="Van Veldhuisen">Dirk J. Van Veldhuisen</name>
<name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C M" last="Witteman">Jacqueline C M. Witteman</name>
</country>
<country name="États-Unis"><region name="Massachusetts"><name sortKey="Thompson, John F" sort="Thompson, John F" uniqKey="Thompson J" first="John F" last="Thompson">John F. Thompson</name>
</region>
<name sortKey="Horne, Benjamin D" sort="Horne, Benjamin D" uniqKey="Horne B" first="Benjamin D" last="Horne">Benjamin D. Horne</name>
<name sortKey="Li, Tricia Y" sort="Li, Tricia Y" uniqKey="Li T" first="Tricia Y." last="Li">Tricia Y. Li</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="François" last="Cambien">François Cambien</name>
</region>
<name sortKey="Nicaud, Viviane" sort="Nicaud, Viviane" uniqKey="Nicaud V" first="Viviane" last="Nicaud">Viviane Nicaud</name>
<name sortKey="Poirer, Odette" sort="Poirer, Odette" uniqKey="Poirer O" first="Odette" last="Poirer">Odette Poirer</name>
</country>
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</noRegion>
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<name sortKey="Savolainen, Markku J" sort="Savolainen, Markku J" uniqKey="Savolainen M" first="Markku J." last="Savolainen">Markku J. Savolainen</name>
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</noRegion>
</country>
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</record>
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