Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
Identifieur interne : 002442 ( Pmc/Checkpoint ); précédent : 002441; suivant : 002443Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
Auteurs : Rachel M. Freathy [Royaume-Uni] ; Dennis O. Mook-Kanamori [Pays-Bas] ; Ulla Sovio [Royaume-Uni] ; Inga Prokopenko [Royaume-Uni] ; Nicholas J. Timpson [Royaume-Uni] ; Diane J. Berry [Royaume-Uni] ; Nicole M. Warrington ; Elisabeth Widen [Finlande] ; Jouke Jan Hottenga [Pays-Bas] ; Marika Kaakinen [Finlande] ; Leslie A. Lange [États-Unis] ; Jonathan P. Bradfield [États-Unis] ; Marjan Kerkhof [Pays-Bas] ; Julie A. Marsh ; Reedik M Gi [Royaume-Uni] ; Chih-Mei Chen [Allemagne] ; Helen N. Lyon [États-Unis] ; Mirna Kirin [Royaume-Uni] ; Linda S. Adair [États-Unis] ; Yurii S. Aulchenko [Pays-Bas] ; Amanda J. Bennett [Royaume-Uni] ; Judith B. Borja [Philippines] ; Nabila Bouatia-Naji [France] ; Pimphen Charoen [Royaume-Uni, Thaïlande] ; Lachlan J M. Coin [Royaume-Uni] ; Diana L. Cousminer [Finlande] ; Eco J. C. De Geus [Pays-Bas] ; Panos Deloukas [Royaume-Uni] ; Paul Elliott [Royaume-Uni] ; David M. Evans [Royaume-Uni] ; Philippe Froguel [France, Royaume-Uni] ; Beate Glaser [Royaume-Uni] ; Christopher J. Groves [Royaume-Uni] ; Anna-Liisa Hartikainen [Finlande] ; Neelam Hassanali [Royaume-Uni] ; Joel N. Hirschhorn [États-Unis] ; Albert Hofman [Pays-Bas] ; Jeff M P. Holly [Royaume-Uni] ; Elina Hyppönen [Royaume-Uni] ; Stavroula Kanoni [Grèce] ; Bridget A. Knight [Royaume-Uni] ; Jaana Laitinen [Finlande] ; Cecilia M. Lindgren [Royaume-Uni] ; Wendy L. Mcardle [Royaume-Uni] ; Paul F. O'Reilly [Royaume-Uni] ; Craig E. Pennell ; Dirkje S. Postma [Pays-Bas] ; Anneli Pouta [Finlande] ; Adaikalavan Ramasamy [Royaume-Uni] ; Nigel W. Rayner [Royaume-Uni] ; Susan M. Ring [Royaume-Uni] ; Fernando Rivadeneira [Pays-Bas] ; Beverley M. Shields [Royaume-Uni] ; David P. Strachan [Royaume-Uni] ; Ida Surakka [Finlande] ; Anja Taanila [Finlande] ; Carla Tiesler [Allemagne] ; Andre G. Uitterlinden [Pays-Bas] ; Cornelia M. Van Duijn [Pays-Bas] ; Alet H. Wijga [Pays-Bas] ; Gonneke Willemsen [Pays-Bas] ; Haitao Zhang [États-Unis] ; Jianhua Zhao [États-Unis] ; James F. Wilson [Royaume-Uni] ; Eric A P. Steegers [Pays-Bas] ; Andrew T. Hattersley [Royaume-Uni] ; Johan G. Eriksson [Finlande] ; Leena Peltonen [Finlande, Royaume-Uni, États-Unis] ; Karen L. Mohlke [États-Unis] ; Struan F A. Grant [États-Unis] ; Hakon Hakonarson [États-Unis] ; Gerard H. Koppelman [Pays-Bas] ; George V. Dedoussis [Grèce] ; Joachim Heinrich [Allemagne] ; Matthew W. Gillman [États-Unis] ; Lyle J. Palmer ; Timothy M. Frayling [Royaume-Uni] ; Dorret I. Boomsma [Pays-Bas] ; George Davey Smith [Royaume-Uni] ; Chris Power [Royaume-Uni] ; Vincent W V. Jaddoe [Pays-Bas] ; Marjo-Riitta Jarvelin [Royaume-Uni, Finlande] ; Mark I. Mccarthy [Royaume-Uni]Source :
- Nature genetics [ 1061-4036 ] ; 2010.
Abstract
To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (N=10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in thirteen replication studies (N=27,591). Rs900400 near
Url:
DOI: 10.1038/ng.567
PubMed: 20372150
PubMed Central: 2862164
Affiliations:
- Allemagne, Finlande, France, Grèce, Pays-Bas, Philippines, Royaume-Uni, Thaïlande, États-Unis
- Angleterre, Attique(région), Bavière, Caroline du Nord, District de Haute-Bavière, Grand Londres, Groningue (province), Hauts-de-France, Hollande-Méridionale, Hollande-Septentrionale, Massachusetts, Nord-Pas-de-Calais, Oxfordshire, Uusimaa, Écosse
- Amsterdam, Athènes, Groningue, Groningue (ville), Helsinki, Kallithéa, Lille, Londres, Munich, Oxford, Rotterdam, Édimbourg
- Université Harokopio, Université Louis-et-Maximilien de Munich, Université d'Helsinki, Université d'Oxford, Université d'Édimbourg, Université de Groningue, Université de Londres
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Variants in <italic>ADCY5</italic> and near <italic>CCNL1</italic> are associated with fetal growth and birth weight</title><author><name sortKey="Freathy, Rachel M" sort="Freathy, Rachel M" uniqKey="Freathy R" first="Rachel M" last="Freathy">Rachel M. Freathy</name><affiliation wicri:level="1"><nlm:aff id="A1"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, EX1 2LU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, EX1 2LU</wicri:regionArea><wicri:noRegion>EX1 2LU</wicri:noRegion></affiliation></author><author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatrics, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Pediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A4"> The Generation R Study, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> The Generation R Study, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A7"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name><affiliation wicri:level="1"><nlm:aff id="A8"> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Berry, Diane J" sort="Berry, Diane J" uniqKey="Berry D" first="Diane J" last="Berry">Diane J. Berry</name><affiliation wicri:level="3"><nlm:aff id="A9"> Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M" last="Warrington">Nicole M. Warrington</name><affiliation><nlm:aff id="A10"> Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</nlm:aff><wicri:noCountry code="subfield">The University of Western Australia</wicri:noCountry></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation wicri:level="1"><nlm:aff id="A11"> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20), 00014 University of Helsinki</nlm:aff><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName><wicri:regionArea> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20)</wicri:regionArea><wicri:noRegion>Tukholmankatu 8 (P.O: Box 20)</wicri:noRegion></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke Jan" last="Hottenga">Jouke Jan Hottenga</name><affiliation wicri:level="3"><nlm:aff id="A12"> Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation wicri:level="1"><nlm:aff id="A13"> Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A14"> Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A" last="Lange">Leslie A. Lange</name><affiliation wicri:level="2"><nlm:aff id="A15"> Department of Genetics, University of North Carolina, Chapel Hill, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Genetics, University of North Carolina, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P" last="Bradfield">Jonathan P. Bradfield</name><affiliation wicri:level="1"><nlm:aff id="A16"> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name><affiliation wicri:level="4"><nlm:aff id="A17"> Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, University Medical Center Groningen, University of Groningen</wicri:regionArea><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Marsh, Julie A" sort="Marsh, Julie A" uniqKey="Marsh J" first="Julie A" last="Marsh">Julie A. Marsh</name><affiliation><nlm:aff id="A10"> Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</nlm:aff><wicri:noCountry code="subfield">The University of Western Australia</wicri:noCountry></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A7"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Chen, Chih Mei" sort="Chen, Chih Mei" uniqKey="Chen C" first="Chih-Mei" last="Chen">Chih-Mei Chen</name><affiliation wicri:level="1"><nlm:aff id="A18"> Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A19"> Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Lyon, Helen N" sort="Lyon, Helen N" uniqKey="Lyon H" first="Helen N" last="Lyon">Helen N. Lyon</name><affiliation wicri:level="2"><nlm:aff id="A20"> Division of Genetics, Program in Genomics, Children's Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Genetics, Program in Genomics, Children's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A21"> Department of Pediatrics, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Pediatrics, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name><affiliation wicri:level="4"><nlm:aff id="A22"> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Adair, Linda S" sort="Adair, Linda S" uniqKey="Adair L" first="Linda S" last="Adair">Linda S. Adair</name><affiliation wicri:level="2"><nlm:aff id="A23"> Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Nutrition, University of North Carolina, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S" last="Aulchenko">Yurii S. Aulchenko</name><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J" last="Bennett">Amanda J. Bennett</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Borja, Judith B" sort="Borja, Judith B" uniqKey="Borja J" first="Judith B" last="Borja">Judith B. Borja</name><affiliation wicri:level="1"><nlm:aff id="A24"> Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines</nlm:aff><country xml:lang="fr">Philippines</country><wicri:regionArea> Office of Population Studies Foundation, University of San Carlos, Cebu City</wicri:regionArea><wicri:noRegion>Cebu City</wicri:noRegion></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation wicri:level="3"><nlm:aff id="A25"> CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Sant, University, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Sant, University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A26"> Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea> Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Coin, Lachlan J M" sort="Coin, Lachlan J M" uniqKey="Coin L" first="Lachlan J M" last="Coin">Lachlan J M. Coin</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L" last="Cousminer">Diana L. Cousminer</name><affiliation wicri:level="1"><nlm:aff id="A11"> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20), 00014 University of Helsinki</nlm:aff><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName><wicri:regionArea> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20)</wicri:regionArea><wicri:noRegion>Tukholmankatu 8 (P.O: Box 20)</wicri:noRegion></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation wicri:level="3"><nlm:aff id="A12"> Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation wicri:level="1"><nlm:aff id="A27"> Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton Cambridge, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton Cambridge, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><affiliation wicri:level="1"><nlm:aff id="A8"> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="3"><nlm:aff id="A25"> CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Sant, University, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Sant, University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A28"> Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Genomic Medicine, Hammersmith Hospital, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Glaser, Beate" sort="Glaser, Beate" uniqKey="Glaser B" first="Beate" last="Glaser">Beate Glaser</name><affiliation wicri:level="1"><nlm:aff id="A8"> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A29"> Children of the Nineties, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Children of the Nineties, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J" last="Groves">Christopher J. Groves</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="A30"> Institute of Clinical Medicine, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Institute of Clinical Medicine, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Hassanali, Neelam" sort="Hassanali, Neelam" uniqKey="Hassanali N" first="Neelam" last="Hassanali">Neelam Hassanali</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N" last="Hirschhorn">Joel N. Hirschhorn</name><affiliation wicri:level="2"><nlm:aff id="A20"> Division of Genetics, Program in Genomics, Children's Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Genetics, Program in Genomics, Children's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A31"> Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A32"> Department of Genetics, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Genetics, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A33"> Division of Endocrinology, Children's Hospital, Boston, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Division of Endocrinology, Children's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M P" last="Holly">Jeff M P. Holly</name><affiliation wicri:level="1"><nlm:aff id="A34"> Department of Clinical Science at North Bristol, University of Bristol, Paul O'Gorman Lifeline Centre, Southmead Hospital, Bristol BS10 5NB, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Clinical Science at North Bristol, University of Bristol, Paul O'Gorman Lifeline Centre, Southmead Hospital, Bristol BS10 5NB</wicri:regionArea><wicri:noRegion>Bristol BS10 5NB</wicri:noRegion></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation wicri:level="3"><nlm:aff id="A9"> Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation wicri:level="4"><nlm:aff id="A35"> Department of Dietetics-Nutrition, Harokopio University, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Dietetics-Nutrition, Harokopio University</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><settlement type="town">Kallithéa</settlement><region nuts="2" type="region">Attique(région)</region></placeName><orgName type="university">Université Harokopio</orgName></affiliation></author><author><name sortKey="Knight, Bridget A" sort="Knight, Bridget A" uniqKey="Knight B" first="Bridget A" last="Knight">Bridget A. Knight</name><affiliation wicri:level="1"><nlm:aff id="A36"> Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, EX2 5DW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, EX2 5DW</wicri:regionArea><wicri:noRegion>EX2 5DW</wicri:noRegion></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation wicri:level="1"><nlm:aff id="A37"> National Institute of Occupational Health, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> National Institute of Occupational Health</wicri:regionArea></affiliation></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M" last="Lindgren">Cecilia M. Lindgren</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A7"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation wicri:level="1"><nlm:aff id="A38"> Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="O Reilly, Paul F" sort="O Reilly, Paul F" uniqKey="O Reilly P" first="Paul F" last="O'Reilly">Paul F. O'Reilly</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E" last="Pennell">Craig E. Pennell</name><affiliation><nlm:aff id="A39"> School of Women's & Infants' Health, The University of Western Australia</nlm:aff><wicri:noCountry code="subfield">The University of Western Australia</wicri:noCountry></affiliation></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S" last="Postma">Dirkje S. Postma</name><affiliation wicri:level="3"><nlm:aff id="A40"> Department of Pulmonology, University Medical Center, University of Groningen, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Pulmonology, University Medical Center, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation wicri:level="1"><nlm:aff id="A41"> National Institute of Health and Welfare, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> National Institute of Health and Welfare, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A42"> Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W" last="Rayner">Nigel W. Rayner</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A7"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M" last="Ring">Susan M. Ring</name><affiliation wicri:level="1"><nlm:aff id="A38"> Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A43"> Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Shields, Beverley M" sort="Shields, Beverley M" uniqKey="Shields B" first="Beverley M" last="Shields">Beverley M. Shields</name><affiliation wicri:level="1"><nlm:aff id="A36"> Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, EX2 5DW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, EX2 5DW</wicri:regionArea><wicri:noRegion>EX2 5DW</wicri:noRegion></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation wicri:level="4"><nlm:aff id="A44"> Division of Community Health Sciences, St. George's, University of London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Division of Community Health Sciences, St. George's, University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation wicri:level="1"><nlm:aff id="A11"> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20), 00014 University of Helsinki</nlm:aff><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName><wicri:regionArea> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20)</wicri:regionArea><wicri:noRegion>Tukholmankatu 8 (P.O: Box 20)</wicri:noRegion></affiliation></author><author><name sortKey="Taanila, Anja" sort="Taanila, Anja" uniqKey="Taanila A" first="Anja" last="Taanila">Anja Taanila</name><affiliation wicri:level="1"><nlm:aff id="A13"> Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name><affiliation wicri:level="1"><nlm:aff id="A18"> Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A19"> Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A43"> Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wijga, Alet H" sort="Wijga, Alet H" uniqKey="Wijga A" first="Alet H" last="Wijga">Alet H. Wijga</name><affiliation wicri:level="1"><nlm:aff id="A45"> Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation wicri:level="3"><nlm:aff id="A12"> Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Zhang, Haitao" sort="Zhang, Haitao" uniqKey="Zhang H" first="Haitao" last="Zhang">Haitao Zhang</name><affiliation wicri:level="1"><nlm:aff id="A16"> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Jianhua" sort="Zhao, Jianhua" uniqKey="Zhao J" first="Jianhua" last="Zhao">Jianhua Zhao</name><affiliation wicri:level="1"><nlm:aff id="A46"> Division of Human Genetics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Human Genetics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation wicri:level="4"><nlm:aff id="A22"> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A P" last="Steegers">Eric A P. Steegers</name><affiliation wicri:level="3"><nlm:aff id="A47"> Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T" last="Hattersley">Andrew T. Hattersley</name><affiliation wicri:level="1"><nlm:aff id="A36"> Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, EX2 5DW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, EX2 5DW</wicri:regionArea><wicri:noRegion>EX2 5DW</wicri:noRegion></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="1"><nlm:aff id="A48"> Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea> Helsinki University Central Hospital, Unit of General Practice, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A49"> Department of General Practice, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Department of General Practice, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A50"> Folkhälsan Research Centre, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Folkhälsan Research Centre, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A51"> National Institute for Health and Welfare, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><affiliation wicri:level="1"><nlm:aff id="A11"> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20), 00014 University of Helsinki</nlm:aff><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName><wicri:regionArea> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20)</wicri:regionArea><wicri:noRegion>Tukholmankatu 8 (P.O: Box 20)</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A27"> Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton Cambridge, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton Cambridge, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A52"> Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Broad Institute of Harvard and MIT, Cambridge, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L" last="Mohlke">Karen L. Mohlke</name><affiliation wicri:level="2"><nlm:aff id="A15"> Department of Genetics, University of North Carolina, Chapel Hill, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Genetics, University of North Carolina, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F A" last="Grant">Struan F A. Grant</name><affiliation wicri:level="1"><nlm:aff id="A16"> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A46"> Division of Human Genetics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Human Genetics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A53"> Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Philadelphia Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="1"><nlm:aff id="A16"> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A46"> Division of Human Genetics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Human Genetics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A53"> Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Philadelphia Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H" last="Koppelman">Gerard H. Koppelman</name><affiliation wicri:level="3"><nlm:aff id="A54"> Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center, University of Groningen, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V" last="Dedoussis">George V. Dedoussis</name><affiliation wicri:level="4"><nlm:aff id="A35"> Department of Dietetics-Nutrition, Harokopio University, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Dietetics-Nutrition, Harokopio University</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><settlement type="town">Kallithéa</settlement><region nuts="2" type="region">Attique(région)</region></placeName><orgName type="university">Université Harokopio</orgName></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation wicri:level="1"><nlm:aff id="A18"> Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Gillman, Matthew W" sort="Gillman, Matthew W" uniqKey="Gillman M" first="Matthew W" last="Gillman">Matthew W. Gillman</name><affiliation wicri:level="2"><nlm:aff id="A55"> Obesity Prevention Program, Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Obesity Prevention Program, Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A10"> Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</nlm:aff><wicri:noCountry code="subfield">The University of Western Australia</wicri:noCountry></affiliation></author><author><name sortKey="Frayling, Timothy M" sort="Frayling, Timothy M" uniqKey="Frayling T" first="Timothy M" last="Frayling">Timothy M. Frayling</name><affiliation wicri:level="1"><nlm:aff id="A1"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, EX1 2LU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, EX1 2LU</wicri:regionArea><wicri:noRegion>EX1 2LU</wicri:noRegion></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="3"><nlm:aff id="A12"> Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation wicri:level="1"><nlm:aff id="A8"> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation wicri:level="3"><nlm:aff id="A9"> Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W V" last="Jaddoe">Vincent W V. Jaddoe</name><affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatrics, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Pediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A13"> Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A14"> Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A41"> National Institute of Health and Welfare, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> National Institute of Health and Welfare, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A7"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A56"> Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LJ</wicri:regionArea><wicri:noRegion>Oxford OX3 7LJ</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20372150</idno><idno type="pmc">2862164</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862164</idno><idno type="RBID">PMC:2862164</idno><idno type="doi">10.1038/ng.567</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002E02</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E02</idno><idno type="wicri:Area/Pmc/Curation">002C52</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C52</idno><idno type="wicri:Area/Pmc/Checkpoint">002442</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002442</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Variants in <italic>ADCY5</italic> and near <italic>CCNL1</italic> are associated with fetal growth and birth weight</title><author><name sortKey="Freathy, Rachel M" sort="Freathy, Rachel M" uniqKey="Freathy R" first="Rachel M" last="Freathy">Rachel M. Freathy</name><affiliation wicri:level="1"><nlm:aff id="A1"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, EX1 2LU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, EX1 2LU</wicri:regionArea><wicri:noRegion>EX1 2LU</wicri:noRegion></affiliation></author><author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatrics, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Pediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A4"> The Generation R Study, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> The Generation R Study, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A7"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name><affiliation wicri:level="1"><nlm:aff id="A8"> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Berry, Diane J" sort="Berry, Diane J" uniqKey="Berry D" first="Diane J" last="Berry">Diane J. Berry</name><affiliation wicri:level="3"><nlm:aff id="A9"> Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M" last="Warrington">Nicole M. Warrington</name><affiliation><nlm:aff id="A10"> Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</nlm:aff><wicri:noCountry code="subfield">The University of Western Australia</wicri:noCountry></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation wicri:level="1"><nlm:aff id="A11"> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20), 00014 University of Helsinki</nlm:aff><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName><wicri:regionArea> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20)</wicri:regionArea><wicri:noRegion>Tukholmankatu 8 (P.O: Box 20)</wicri:noRegion></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke Jan" last="Hottenga">Jouke Jan Hottenga</name><affiliation wicri:level="3"><nlm:aff id="A12"> Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation wicri:level="1"><nlm:aff id="A13"> Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A14"> Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A" last="Lange">Leslie A. Lange</name><affiliation wicri:level="2"><nlm:aff id="A15"> Department of Genetics, University of North Carolina, Chapel Hill, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Genetics, University of North Carolina, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P" last="Bradfield">Jonathan P. Bradfield</name><affiliation wicri:level="1"><nlm:aff id="A16"> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name><affiliation wicri:level="4"><nlm:aff id="A17"> Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, University Medical Center Groningen, University of Groningen</wicri:regionArea><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Marsh, Julie A" sort="Marsh, Julie A" uniqKey="Marsh J" first="Julie A" last="Marsh">Julie A. Marsh</name><affiliation><nlm:aff id="A10"> Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</nlm:aff><wicri:noCountry code="subfield">The University of Western Australia</wicri:noCountry></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A7"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Chen, Chih Mei" sort="Chen, Chih Mei" uniqKey="Chen C" first="Chih-Mei" last="Chen">Chih-Mei Chen</name><affiliation wicri:level="1"><nlm:aff id="A18"> Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A19"> Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Lyon, Helen N" sort="Lyon, Helen N" uniqKey="Lyon H" first="Helen N" last="Lyon">Helen N. Lyon</name><affiliation wicri:level="2"><nlm:aff id="A20"> Division of Genetics, Program in Genomics, Children's Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Genetics, Program in Genomics, Children's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A21"> Department of Pediatrics, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Pediatrics, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name><affiliation wicri:level="4"><nlm:aff id="A22"> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Adair, Linda S" sort="Adair, Linda S" uniqKey="Adair L" first="Linda S" last="Adair">Linda S. Adair</name><affiliation wicri:level="2"><nlm:aff id="A23"> Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Nutrition, University of North Carolina, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S" last="Aulchenko">Yurii S. Aulchenko</name><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J" last="Bennett">Amanda J. Bennett</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Borja, Judith B" sort="Borja, Judith B" uniqKey="Borja J" first="Judith B" last="Borja">Judith B. Borja</name><affiliation wicri:level="1"><nlm:aff id="A24"> Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines</nlm:aff><country xml:lang="fr">Philippines</country><wicri:regionArea> Office of Population Studies Foundation, University of San Carlos, Cebu City</wicri:regionArea><wicri:noRegion>Cebu City</wicri:noRegion></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation wicri:level="3"><nlm:aff id="A25"> CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Sant, University, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Sant, University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A26"> Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea> Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Coin, Lachlan J M" sort="Coin, Lachlan J M" uniqKey="Coin L" first="Lachlan J M" last="Coin">Lachlan J M. Coin</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L" last="Cousminer">Diana L. Cousminer</name><affiliation wicri:level="1"><nlm:aff id="A11"> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20), 00014 University of Helsinki</nlm:aff><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName><wicri:regionArea> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20)</wicri:regionArea><wicri:noRegion>Tukholmankatu 8 (P.O: Box 20)</wicri:noRegion></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation wicri:level="3"><nlm:aff id="A12"> Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation wicri:level="1"><nlm:aff id="A27"> Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton Cambridge, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton Cambridge, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><affiliation wicri:level="1"><nlm:aff id="A8"> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="3"><nlm:aff id="A25"> CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Sant, University, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Sant, University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A28"> Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Genomic Medicine, Hammersmith Hospital, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Glaser, Beate" sort="Glaser, Beate" uniqKey="Glaser B" first="Beate" last="Glaser">Beate Glaser</name><affiliation wicri:level="1"><nlm:aff id="A8"> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A29"> Children of the Nineties, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Children of the Nineties, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J" last="Groves">Christopher J. Groves</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="A30"> Institute of Clinical Medicine, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Institute of Clinical Medicine, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Hassanali, Neelam" sort="Hassanali, Neelam" uniqKey="Hassanali N" first="Neelam" last="Hassanali">Neelam Hassanali</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N" last="Hirschhorn">Joel N. Hirschhorn</name><affiliation wicri:level="2"><nlm:aff id="A20"> Division of Genetics, Program in Genomics, Children's Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Genetics, Program in Genomics, Children's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A31"> Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A32"> Department of Genetics, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Genetics, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A33"> Division of Endocrinology, Children's Hospital, Boston, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Division of Endocrinology, Children's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M P" last="Holly">Jeff M P. Holly</name><affiliation wicri:level="1"><nlm:aff id="A34"> Department of Clinical Science at North Bristol, University of Bristol, Paul O'Gorman Lifeline Centre, Southmead Hospital, Bristol BS10 5NB, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Clinical Science at North Bristol, University of Bristol, Paul O'Gorman Lifeline Centre, Southmead Hospital, Bristol BS10 5NB</wicri:regionArea><wicri:noRegion>Bristol BS10 5NB</wicri:noRegion></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation wicri:level="3"><nlm:aff id="A9"> Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation wicri:level="4"><nlm:aff id="A35"> Department of Dietetics-Nutrition, Harokopio University, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Dietetics-Nutrition, Harokopio University</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><settlement type="town">Kallithéa</settlement><region nuts="2" type="region">Attique(région)</region></placeName><orgName type="university">Université Harokopio</orgName></affiliation></author><author><name sortKey="Knight, Bridget A" sort="Knight, Bridget A" uniqKey="Knight B" first="Bridget A" last="Knight">Bridget A. Knight</name><affiliation wicri:level="1"><nlm:aff id="A36"> Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, EX2 5DW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, EX2 5DW</wicri:regionArea><wicri:noRegion>EX2 5DW</wicri:noRegion></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation wicri:level="1"><nlm:aff id="A37"> National Institute of Occupational Health, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> National Institute of Occupational Health</wicri:regionArea></affiliation></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M" last="Lindgren">Cecilia M. Lindgren</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A7"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation wicri:level="1"><nlm:aff id="A38"> Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="O Reilly, Paul F" sort="O Reilly, Paul F" uniqKey="O Reilly P" first="Paul F" last="O'Reilly">Paul F. O'Reilly</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E" last="Pennell">Craig E. Pennell</name><affiliation><nlm:aff id="A39"> School of Women's & Infants' Health, The University of Western Australia</nlm:aff><wicri:noCountry code="subfield">The University of Western Australia</wicri:noCountry></affiliation></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S" last="Postma">Dirkje S. Postma</name><affiliation wicri:level="3"><nlm:aff id="A40"> Department of Pulmonology, University Medical Center, University of Groningen, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Pulmonology, University Medical Center, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation wicri:level="1"><nlm:aff id="A41"> National Institute of Health and Welfare, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> National Institute of Health and Welfare, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A42"> Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W" last="Rayner">Nigel W. Rayner</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A7"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M" last="Ring">Susan M. Ring</name><affiliation wicri:level="1"><nlm:aff id="A38"> Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A43"> Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Shields, Beverley M" sort="Shields, Beverley M" uniqKey="Shields B" first="Beverley M" last="Shields">Beverley M. Shields</name><affiliation wicri:level="1"><nlm:aff id="A36"> Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, EX2 5DW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, EX2 5DW</wicri:regionArea><wicri:noRegion>EX2 5DW</wicri:noRegion></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation wicri:level="4"><nlm:aff id="A44"> Division of Community Health Sciences, St. George's, University of London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Division of Community Health Sciences, St. George's, University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation wicri:level="1"><nlm:aff id="A11"> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20), 00014 University of Helsinki</nlm:aff><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName><wicri:regionArea> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20)</wicri:regionArea><wicri:noRegion>Tukholmankatu 8 (P.O: Box 20)</wicri:noRegion></affiliation></author><author><name sortKey="Taanila, Anja" sort="Taanila, Anja" uniqKey="Taanila A" first="Anja" last="Taanila">Anja Taanila</name><affiliation wicri:level="1"><nlm:aff id="A13"> Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name><affiliation wicri:level="1"><nlm:aff id="A18"> Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A19"> Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A43"> Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wijga, Alet H" sort="Wijga, Alet H" uniqKey="Wijga A" first="Alet H" last="Wijga">Alet H. Wijga</name><affiliation wicri:level="1"><nlm:aff id="A45"> Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation wicri:level="3"><nlm:aff id="A12"> Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Zhang, Haitao" sort="Zhang, Haitao" uniqKey="Zhang H" first="Haitao" last="Zhang">Haitao Zhang</name><affiliation wicri:level="1"><nlm:aff id="A16"> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Jianhua" sort="Zhao, Jianhua" uniqKey="Zhao J" first="Jianhua" last="Zhao">Jianhua Zhao</name><affiliation wicri:level="1"><nlm:aff id="A46"> Division of Human Genetics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Human Genetics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation wicri:level="4"><nlm:aff id="A22"> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A P" last="Steegers">Eric A P. Steegers</name><affiliation wicri:level="3"><nlm:aff id="A47"> Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T" last="Hattersley">Andrew T. Hattersley</name><affiliation wicri:level="1"><nlm:aff id="A36"> Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, EX2 5DW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, EX2 5DW</wicri:regionArea><wicri:noRegion>EX2 5DW</wicri:noRegion></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="1"><nlm:aff id="A48"> Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea> Helsinki University Central Hospital, Unit of General Practice, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A49"> Department of General Practice, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Department of General Practice, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A50"> Folkhälsan Research Centre, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Folkhälsan Research Centre, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A51"> National Institute for Health and Welfare, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><affiliation wicri:level="1"><nlm:aff id="A11"> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20), 00014 University of Helsinki</nlm:aff><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName><wicri:regionArea> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20)</wicri:regionArea><wicri:noRegion>Tukholmankatu 8 (P.O: Box 20)</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A27"> Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton Cambridge, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton Cambridge, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A52"> Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Broad Institute of Harvard and MIT, Cambridge, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L" last="Mohlke">Karen L. Mohlke</name><affiliation wicri:level="2"><nlm:aff id="A15"> Department of Genetics, University of North Carolina, Chapel Hill, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Genetics, University of North Carolina, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F A" last="Grant">Struan F A. Grant</name><affiliation wicri:level="1"><nlm:aff id="A16"> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A46"> Division of Human Genetics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Human Genetics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A53"> Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Philadelphia Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="1"><nlm:aff id="A16"> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A46"> Division of Human Genetics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Human Genetics, The Children's Hospital of Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A53"> Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia Pennsylvania 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Philadelphia Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H" last="Koppelman">Gerard H. Koppelman</name><affiliation wicri:level="3"><nlm:aff id="A54"> Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center, University of Groningen, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V" last="Dedoussis">George V. Dedoussis</name><affiliation wicri:level="4"><nlm:aff id="A35"> Department of Dietetics-Nutrition, Harokopio University, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Dietetics-Nutrition, Harokopio University</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><settlement type="town">Kallithéa</settlement><region nuts="2" type="region">Attique(région)</region></placeName><orgName type="university">Université Harokopio</orgName></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation wicri:level="1"><nlm:aff id="A18"> Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Gillman, Matthew W" sort="Gillman, Matthew W" uniqKey="Gillman M" first="Matthew W" last="Gillman">Matthew W. Gillman</name><affiliation wicri:level="2"><nlm:aff id="A55"> Obesity Prevention Program, Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Obesity Prevention Program, Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A10"> Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</nlm:aff><wicri:noCountry code="subfield">The University of Western Australia</wicri:noCountry></affiliation></author><author><name sortKey="Frayling, Timothy M" sort="Frayling, Timothy M" uniqKey="Frayling T" first="Timothy M" last="Frayling">Timothy M. Frayling</name><affiliation wicri:level="1"><nlm:aff id="A1"> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, EX1 2LU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, EX1 2LU</wicri:regionArea><wicri:noRegion>EX1 2LU</wicri:noRegion></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="3"><nlm:aff id="A12"> Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation wicri:level="1"><nlm:aff id="A8"> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN</wicri:regionArea><wicri:noRegion>BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation wicri:level="3"><nlm:aff id="A9"> Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W V" last="Jaddoe">Vincent W V. Jaddoe</name><affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatrics, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Pediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3"> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation wicri:level="3"><nlm:aff id="A5"> Department of Epidemiology and Public Health, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A13"> Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A14"> Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A41"> National Institute of Health and Welfare, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> National Institute of Health and Welfare, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name><affiliation wicri:level="4"><nlm:aff id="A6"> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</nlm:aff><orgName type="university">Université d'Oxford</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A7"> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A56"> Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LJ</wicri:regionArea><wicri:noRegion>Oxford OX3 7LJ</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>INTRODUCTORY PARAGRAPH</title><p id="P9">To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (N=10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in thirteen replication studies (N=27,591). Rs900400 near <italic>LEKR1</italic> and <italic>CCNL1</italic> (<italic>P</italic>=2×10<sup>−35</sup>), and rs9883204 in <italic>ADCY5</italic> (<italic>P</italic>=7×10<sup>−15</sup>) were robustly associated with birth weight. Correlated SNPs in <italic>ADCY5</italic> were recently implicated in regulation of glucose levels and type 2 diabetes susceptibility,<xref ref-type="bibr" rid="R1">1</xref> providing evidence that the well described association between lower birth weight and subsequent type 2 diabetes<xref ref-type="bibr" rid="R2">2</xref>,<xref ref-type="bibr" rid="R3">3</xref> has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, the 9% of Europeans with 4 birth weight-lowering alleles were, on average, 113g (95%CI 89-137g) lighter at birth than the 24% with 0 or 1 allele (<italic>P<sub>trend</sub></italic>=7×10<sup>−30</sup>). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy.<xref ref-type="bibr" rid="R4">4</xref></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dupuis, J" uniqKey="Dupuis J">J Dupuis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barker, Dj" uniqKey="Barker D">DJ Barker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jarvelin, Mr" uniqKey="Jarvelin M">MR Jarvelin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernstein, Im" uniqKey="Bernstein I">IM Bernstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Battaglia, Fc" uniqKey="Battaglia F">FC Battaglia</name></author><author><name sortKey="Lubchenco, Lo" uniqKey="Lubchenco L">LO Lubchenco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Acker, Db" uniqKey="Acker D">DB Acker</name></author><author><name sortKey="Sachs, Bp" uniqKey="Sachs B">BP Sachs</name></author><author><name sortKey="Friedman, Ea" uniqKey="Friedman E">EA Friedman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kramer, Ms" uniqKey="Kramer M">MS Kramer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jarvelin, Mr" uniqKey="Jarvelin M">MR Jarvelin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knight, B" uniqKey="Knight B">B Knight</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klebanoff, Ma" uniqKey="Klebanoff M">MA Klebanoff</name></author><author><name sortKey="Mednick, Br" uniqKey="Mednick B">BR Mednick</name></author><author><name sortKey="Schulsinger, C" uniqKey="Schulsinger C">C Schulsinger</name></author><author><name sortKey="Secher, Nj" uniqKey="Secher N">NJ Secher</name></author><author><name sortKey="Shiono, Ph" uniqKey="Shiono P">PH Shiono</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hattersley, At" uniqKey="Hattersley A">AT Hattersley</name></author><author><name sortKey="Tooke, Je" uniqKey="Tooke J">JE Tooke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freathy, Rm" uniqKey="Freathy R">RM Freathy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hattersley, At" uniqKey="Hattersley A">AT Hattersley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Higgins, Jp" uniqKey="Higgins J">JP Higgins</name></author><author><name sortKey="Thompson, Sg" uniqKey="Thompson S">SG Thompson</name></author><author><name sortKey="Deeks, Jj" uniqKey="Deeks J">JJ Deeks</name></author><author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freathy, Rm" uniqKey="Freathy R">RM Freathy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weedon, Mn" uniqKey="Weedon M">MN Weedon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willer, Cj" uniqKey="Willer C">CJ Willer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parsons, Tj" uniqKey="Parsons T">TJ Parsons</name></author><author><name sortKey="Power, C" uniqKey="Power C">C Power</name></author><author><name sortKey="Manor, O" uniqKey="Manor O">O Manor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loyer, P" uniqKey="Loyer P">P Loyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dixon, Al" uniqKey="Dixon A">AL Dixon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tesmer, Jj" uniqKey="Tesmer J">JJ Tesmer</name></author><author><name sortKey="Sprang, Sr" uniqKey="Sprang S">SR Sprang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanoune, J" uniqKey="Hanoune J">J Hanoune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ludwig, Mg" uniqKey="Ludwig M">MG Ludwig</name></author><author><name sortKey="Seuwen, K" uniqKey="Seuwen K">K Seuwen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prokopenko, I" uniqKey="Prokopenko I">I Prokopenko</name></author><author><name sortKey="Mccarthy, Mi" uniqKey="Mccarthy M">MI McCarthy</name></author><author><name sortKey="Lindgren, Cm" uniqKey="Lindgren C">CM Lindgren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prokopenko, I" uniqKey="Prokopenko I">I Prokopenko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogura, K" uniqKey="Ogura K">K Ogura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Souza, Vm" uniqKey="D Souza V">VM D'Souza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leach, L" uniqKey="Leach L">L Leach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Baal, Cg" uniqKey="Van Baal C">CG van Baal</name></author><author><name sortKey="Boomsma, Di" uniqKey="Boomsma D">DI Boomsma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lunde, A" uniqKey="Lunde A">A Lunde</name></author><author><name sortKey="Melve, Kk" uniqKey="Melve K">KK Melve</name></author><author><name sortKey="Gjessing, Hk" uniqKey="Gjessing H">HK Gjessing</name></author><author><name sortKey="Skjaerven, R" uniqKey="Skjaerven R">R Skjaerven</name></author><author><name sortKey="Irgens, Lm" uniqKey="Irgens L">LM Irgens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stein, Ad" uniqKey="Stein A">AD Stein</name></author><author><name sortKey="Zybert, Pa" uniqKey="Zybert P">PA Zybert</name></author><author><name sortKey="Van De Bor, M" uniqKey="Van De Bor M">M van de Bor</name></author><author><name sortKey="Lumey, Lh" uniqKey="Lumey L">LH Lumey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krestyaninova, M" uniqKey="Krestyaninova M">M Krestyaninova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devlin, B" uniqKey="Devlin B">B Devlin</name></author><author><name sortKey="Roeder, K" uniqKey="Roeder K">K Roeder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Bakker, Pi" uniqKey="De Bakker P">PI de Bakker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harris, R" uniqKey="Harris R">R Harris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wallace, Bc" uniqKey="Wallace B">BC Wallace</name></author><author><name sortKey="Schmid, Ch" uniqKey="Schmid C">CH Schmid</name></author><author><name sortKey="Lau, J" uniqKey="Lau J">J Lau</name></author><author><name sortKey="Trikalinos, Ta" uniqKey="Trikalinos T">TA Trikalinos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niklasson, A" uniqKey="Niklasson A">A Niklasson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20372150</article-id><article-id pub-id-type="pmc">2862164</article-id><article-id pub-id-type="doi">10.1038/ng.567</article-id><article-id pub-id-type="manuscript">UKMS29218</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Variants in <italic>ADCY5</italic> and near <italic>CCNL1</italic> are associated with fetal growth and birth weight</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Freathy</surname><given-names>Rachel M</given-names></name><xref ref-type="author-notes" rid="FN2">*</xref><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mook-Kanamori</surname><given-names>Dennis O</given-names></name><xref ref-type="author-notes" rid="FN2">*</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Sovio</surname><given-names>Ulla</given-names></name><xref ref-type="author-notes" rid="FN2">*</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Prokopenko</surname><given-names>Inga</given-names></name><xref ref-type="author-notes" rid="FN2">*</xref><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Timpson</surname><given-names>Nicholas J</given-names></name><xref ref-type="author-notes" rid="FN2">*</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Berry</surname><given-names>Diane J</given-names></name><xref ref-type="author-notes" rid="FN2">*</xref><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Warrington</surname><given-names>Nicole M</given-names></name><xref ref-type="author-notes" rid="FN2">*</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Widen</surname><given-names>Elisabeth</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Hottenga</surname><given-names>Jouke Jan</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Kaakinen</surname><given-names>Marika</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Lange</surname><given-names>Leslie A</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Bradfield</surname><given-names>Jonathan P</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Kerkhof</surname><given-names>Marjan</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Marsh</surname><given-names>Julie A</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Mägi</surname><given-names>Reedik</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Chih-Mei</given-names></name><xref ref-type="aff" rid="A18">18</xref><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Lyon</surname><given-names>Helen N</given-names></name><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Kirin</surname><given-names>Mirna</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Adair</surname><given-names>Linda S</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Aulchenko</surname><given-names>Yurii S</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bennett</surname><given-names>Amanda J</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Borja</surname><given-names>Judith B</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Bouatia-Naji</surname><given-names>Nabila</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Charoen</surname><given-names>Pimphen</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Coin</surname><given-names>Lachlan J M</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Cousminer</surname><given-names>Diana L</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>de Geus</surname><given-names>Eco J. C.</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Deloukas</surname><given-names>Panos</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Elliott</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Evans</surname><given-names>David M</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Froguel</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="A25">25</xref><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><collab>The Genetic Investigation of ANthropometric Traits (GIANT) Consortium</collab><xref ref-type="author-notes" rid="FN1">57</xref></contrib><contrib contrib-type="author"><name><surname>Glaser</surname><given-names>Beate</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Groves</surname><given-names>Christopher J</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Hartikainen</surname><given-names>Anna-Liisa</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Hassanali</surname><given-names>Neelam</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Hirschhorn</surname><given-names>Joel N</given-names></name><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A31">31</xref><xref ref-type="aff" rid="A32">32</xref><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Hofman</surname><given-names>Albert</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Holly</surname><given-names>Jeff M P</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Hyppönen</surname><given-names>Elina</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Kanoni</surname><given-names>Stavroula</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Knight</surname><given-names>Bridget A</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Laitinen</surname><given-names>Jaana</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Lindgren</surname><given-names>Cecilia M</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><collab>The Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)</collab><xref ref-type="author-notes" rid="FN1">57</xref></contrib><contrib contrib-type="author"><name><surname>McArdle</surname><given-names>Wendy L</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>O'Reilly</surname><given-names>Paul F</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Pennell</surname><given-names>Craig E</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Postma</surname><given-names>Dirkje S</given-names></name><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Pouta</surname><given-names>Anneli</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Ramasamy</surname><given-names>Adaikalavan</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Rayner</surname><given-names>Nigel W</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Ring</surname><given-names>Susan M</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Rivadeneira</surname><given-names>Fernando</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Shields</surname><given-names>Beverley M</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Strachan</surname><given-names>David P</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Surakka</surname><given-names>Ida</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Taanila</surname><given-names>Anja</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Tiesler</surname><given-names>Carla</given-names></name><xref ref-type="aff" rid="A18">18</xref><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Uitterlinden</surname><given-names>Andre G</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>van Duijn</surname><given-names>Cornelia M</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><collab>The Wellcome Trust Case Control Consortium (WTCCC)</collab><xref ref-type="author-notes" rid="FN1">57</xref></contrib><contrib contrib-type="author"><name><surname>Wijga</surname><given-names>Alet H</given-names></name><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>Willemsen</surname><given-names>Gonneke</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Haitao</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Jianhua</given-names></name><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>James F</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Steegers</surname><given-names>Eric A P</given-names></name><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Hattersley</surname><given-names>Andrew T</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Eriksson</surname><given-names>Johan G</given-names></name><xref ref-type="aff" rid="A48">48</xref><xref ref-type="aff" rid="A49">49</xref><xref ref-type="aff" rid="A50">50</xref><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Peltonen</surname><given-names>Leena</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A27">27</xref><xref ref-type="aff" rid="A52">52</xref></contrib><contrib contrib-type="author"><name><surname>Mohlke</surname><given-names>Karen L</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Grant</surname><given-names>Struan F A</given-names></name><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A46">46</xref><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Hakonarson</surname><given-names>Hakon</given-names></name><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A46">46</xref><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Koppelman</surname><given-names>Gerard H</given-names></name><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Dedoussis</surname><given-names>George V</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Heinrich</surname><given-names>Joachim</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Gillman</surname><given-names>Matthew W</given-names></name><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Palmer</surname><given-names>Lyle J</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Frayling</surname><given-names>Timothy M</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Boomsma</surname><given-names>Dorret I</given-names></name><xref ref-type="corresp" rid="CR2">†</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>George Davey</given-names></name><xref ref-type="corresp" rid="CR3">†</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Power</surname><given-names>Chris</given-names></name><xref ref-type="corresp" rid="CR4">†</xref><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Jaddoe</surname><given-names>Vincent W V</given-names></name><xref ref-type="corresp" rid="CR5">†</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Jarvelin</surname><given-names>Marjo-Riitta</given-names></name><xref ref-type="corresp" rid="CR6">†</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A14">14</xref><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>McCarthy</surname><given-names>Mark I</given-names></name><xref ref-type="corresp" rid="CR7">†</xref><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A56">56</xref></contrib><on-behalf-of>for the Early Growth Genetics (EGG) Consortium</on-behalf-of></contrib-group><aff id="A1"><label>1</label> Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, EX1 2LU, UK</aff><aff id="A2"><label>2</label> Department of Pediatrics, Erasmus Medical Center, Rotterdam, the Netherlands</aff><aff id="A3"><label>3</label> Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</aff><aff id="A4"><label>4</label> The Generation R Study, Erasmus Medical Center, Rotterdam, the Netherlands</aff><aff id="A5"><label>5</label> Department of Epidemiology and Public Health, Imperial College London, London, UK</aff><aff id="A6"><label>6</label> Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ</aff><aff id="A7"><label>7</label> Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK</aff><aff id="A8"><label>8</label> The MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</aff><aff id="A9"><label>9</label> Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, UK</aff><aff id="A10"><label>10</label> Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</aff><aff id="A11"><label>11</label> Insititute for Molecular Medicine Finland (FIMM), Tukholmankatu 8 (P.O: Box 20), 00014 University of Helsinki</aff><aff id="A12"><label>12</label> Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands</aff><aff id="A13"><label>13</label> Institute of Health Sciences, University of Oulu, Oulu, Finland</aff><aff id="A14"><label>14</label> Biocenter Oulu, University of Oulu, Oulu, Finland</aff><aff id="A15"><label>15</label> Department of Genetics, University of North Carolina, Chapel Hill, NC, USA</aff><aff id="A16"><label>16</label> Center for Applied Genomics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</aff><aff id="A17"><label>17</label> Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands</aff><aff id="A18"><label>18</label> Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Germany</aff><aff id="A19"><label>19</label> Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Munich, Germany</aff><aff id="A20"><label>20</label> Division of Genetics, Program in Genomics, Children's Hospital, Boston, MA, USA</aff><aff id="A21"><label>21</label> Department of Pediatrics, Harvard Medical School, Boston, MA, USA</aff><aff id="A22"><label>22</label> Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK.</aff><aff id="A23"><label>23</label> Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA</aff><aff id="A24"><label>24</label> Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines</aff><aff id="A25"><label>25</label> CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Sant, University, Lille, France</aff><aff id="A26"><label>26</label> Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</aff><aff id="A27"><label>27</label> Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton Cambridge, CB10 1SA, UK</aff><aff id="A28"><label>28</label> Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK</aff><aff id="A29"><label>29</label> Children of the Nineties, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</aff><aff id="A30"><label>30</label> Institute of Clinical Medicine, University of Oulu, Oulu, Finland</aff><aff id="A31"><label>31</label> Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA</aff><aff id="A32"><label>32</label> Department of Genetics, Harvard Medical School, Boston, MA, USA</aff><aff id="A33"><label>33</label> Division of Endocrinology, Children's Hospital, Boston, MA, USA.</aff><aff id="A34"><label>34</label> Department of Clinical Science at North Bristol, University of Bristol, Paul O'Gorman Lifeline Centre, Southmead Hospital, Bristol BS10 5NB, UK</aff><aff id="A35"><label>35</label> Department of Dietetics-Nutrition, Harokopio University, Greece</aff><aff id="A36"><label>36</label> Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, EX2 5DW, UK</aff><aff id="A37"><label>37</label> National Institute of Occupational Health, Finland</aff><aff id="A38"><label>38</label> Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK</aff><aff id="A39"><label>39</label> School of Women's & Infants' Health, The University of Western Australia</aff><aff id="A40"><label>40</label> Department of Pulmonology, University Medical Center, University of Groningen, Groningen, the Netherlands</aff><aff id="A41"><label>41</label> National Institute of Health and Welfare, Oulu, Finland</aff><aff id="A42"><label>42</label> Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK</aff><aff id="A43"><label>43</label> Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands</aff><aff id="A44"><label>44</label> Division of Community Health Sciences, St. George's, University of London, London, UK</aff><aff id="A45"><label>45</label> Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands</aff><aff id="A46"><label>46</label> Division of Human Genetics, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA</aff><aff id="A47"><label>47</label> Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, the Netherlands</aff><aff id="A48"><label>48</label> Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland.</aff><aff id="A49"><label>49</label> Department of General Practice, University of Helsinki, Helsinki, Finland</aff><aff id="A50"><label>50</label> Folkhälsan Research Centre, Helsinki, Finland</aff><aff id="A51"><label>51</label> National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A52"><label>52</label> Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</aff><aff id="A53"><label>53</label> Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia Pennsylvania 19104, USA</aff><aff id="A54"><label>54</label> Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center, University of Groningen, Groningen, the Netherlands</aff><aff id="A55"><label>55</label> Obesity Prevention Program, Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA, USA</aff><aff id="A56"><label>56</label> Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LJ, UK</aff><author-notes><fn id="FN1"><label>57</label><p id="P1">A complete list of members is available in a <xref ref-type="supplementary-material" rid="SD1">Supplementary Note</xref>.</p></fn><fn fn-type="equal" id="FN2"><label>*</label><p id="P2">These authors contributed equally to this work.</p></fn><corresp id="CR1"><label>†</label>Corresponding authors; these authors jointly directed this work.</corresp><corresp id="CR0">Corresponding author contact details:</corresp><corresp id="CR2"><bold>Dorret I. Boomsma</bold> Department of Biological Psychology VU University Amsterdam van der Boechorststraat 1 1081 BT Amsterdam the Netherlands Tel. +31 (0)20 598 8787 Fax. +31 (0)20 598 8832 <email>dorret@psy.vu.nl</email></corresp><corresp id="CR3"><bold>George Davey Smith</bold> The MRC Centre for Causal Analyses in Translational Epidemiology University of Bristol Oakfield House Oakfield Grove Bristol BS8 2BN UK Tel. +44 (0)117 3310095 Fax. +44 (0)117 3310123 <email>George.Davey-Smith@bristol.ac.uk</email></corresp><corresp id="CR4"><bold>Chris Power</bold> Centre for Paediatric Epidemiology & Biostatistics MRC Centre of Epidemiology for Child Health University College of London Institute of Child Health London WC1N 1EH UK Tel. +44 (0)20 7242 9789 Fax. +44 (0)20 7905 2381 <email>C.Power@ich.ucl.ac.uk</email></corresp><corresp id="CR5"><bold>Vincent V. W. Jaddoe</bold> Generation R Study Group (Room AE 006) Erasmus Medical Center PO Box 2040 3000 CA, Rotterdam the Netherlands Tel. +31 (0)10 7043405 Fax. +31 (0)10 7044645 <email>v.jaddoe@erasmusmc.nl</email></corresp><corresp id="CR6"><bold>Marjo-Riitta Jarvelin</bold> Department of Epidemiology and Public Health Imperial College London London UK Tel. +44 (0)207 5943345 Fax. +44 (0)207 4022150 <email>m.jarvelin@imperial.ac.uk</email></corresp><corresp id="CR7"><bold>Mark I. McCarthy</bold> Oxford Centre for Diabetes, Endocrinology and Metabolism Churchill Hospital Old Road, Headington Oxford OX3 7LJ UK Tel. +44 (0)1865 857298 Fax. +44 (0)1865 857299 <email>mark.mccarthy@drl.ox.ac.uk</email></corresp><fn id="FN3"><p id="P3">AUTHOR CONTRIBUTIONS</p><p id="P4"><bold>Project Design:</bold> R.M.F., U.S., N.J.T., E.W., M.Kerkhof, H.N.L., L.S.A., J.B.B., E.J.C.D.G., A.-L.H., J.N.H., A.H., E.H., J.L., D.S.P., A.P., A.T., A.H.W., G.W., J.F.W., E.A.P.S., A.T.H., L.P., K.L.M., S.F.A.G., H.H., G.H.K., G.V.D., J.H., M.W.G., L.J.P., T.M.F., D.I.B., G.D.S., C.P., V.W.V.J., M-R.J., M.I.M.</p><p id="P5"><bold>Sample collection and phenotyping:</bold> D.O.M.K., U.S., D.J.B., M.Kaakinen, M.Kerkhof, L.S.A., A.J.B, J.B.B., P.E., A.-L.H., E.H., S.K., B.A.K., J.L., W.L.M., C.E.P., D.S.P., A.P., F.R., B.M.S., D.P.S., A.T., A.G.U., A.H.W., G.W., J.F.W., A.T.H., J.G.E., S.F.A.G., H.H., G.H.K., G.V.D., J.H., M.W.G., L.J.P., G.D.S., C.P., V.W.V.J., M-R.J.</p><p id="P6"><bold>Genotyping:</bold> R.M.F., J.J.H., M.Kerkhof, H.N.L., A.J.B., N.B-N., E.J.C.D.G., P.D., P.E., P.F., C.J.G., N.H., J.N.H., W.L.M., D.S.P., S.M.R., F.R., A.G.U., A.H.W., J.F.W., L.P., S.F.A.G., H.H., G.H.K., D.I.B., M-R.J.</p><p id="P7"><bold>Statistical analysis:</bold> R.M.F., D.O.M.K., U.S., I.P., N.J.T., D.J.B., N.M.W., E.W., J.J.H., M.Kaakinen, L.A.L., J.P.B., M.Kerkhof, J.A.M., R.M., C.M.C., H.N.L., M.Kirin, Y.S.A., P.C., L.J.M.C., D.L.C., D.M.E., B.G., C.M.L., P.O., D.S.P., A.R., N.W.R, B.M.S., I.S., C.T., C.M.V.D., A.H.W., J.Z., H.Z., G.H.K., M.W.G., L.J.P.</p><p id="P8"><bold>Writing:</bold> R.M.F., D.O.M.K., U.S., I.P., N.J.T., D.J.B., J.M.P.H., A.T.H., L.J.P., T.M.F., V.W.V.J., M-R.J., M.I.M.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>29</day><month>3</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>06</day><month>4</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2010</year></pub-date><volume>42</volume><issue>5</issue><fpage>430</fpage><lpage>435</lpage><permissions><license><license-p>Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:
<uri xlink:type="simple" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</uri></license-p></license></permissions><abstract><title>INTRODUCTORY PARAGRAPH</title><p id="P9">To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (N=10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in thirteen replication studies (N=27,591). Rs900400 near <italic>LEKR1</italic> and <italic>CCNL1</italic> (<italic>P</italic>=2×10<sup>−35</sup>), and rs9883204 in <italic>ADCY5</italic> (<italic>P</italic>=7×10<sup>−15</sup>) were robustly associated with birth weight. Correlated SNPs in <italic>ADCY5</italic> were recently implicated in regulation of glucose levels and type 2 diabetes susceptibility,<xref ref-type="bibr" rid="R1">1</xref> providing evidence that the well described association between lower birth weight and subsequent type 2 diabetes<xref ref-type="bibr" rid="R2">2</xref>,<xref ref-type="bibr" rid="R3">3</xref> has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, the 9% of Europeans with 4 birth weight-lowering alleles were, on average, 113g (95%CI 89-137g) lighter at birth than the 24% with 0 or 1 allele (<italic>P<sub>trend</sub></italic>=7×10<sup>−30</sup>). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy.<xref ref-type="bibr" rid="R4">4</xref></p></abstract><funding-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>085541 || WT</award-id></award-group></funding-group></article-meta></front><floats-group><fig id="F1" position="float"><label>Figure 1</label><caption><p>Regional plots of two novel associations with birth weight. For each of the two regions, 3q25 <bold>[A]</bold> and 3q21 <bold>[B]</bold>, directly genotyped and imputed SNPs are plotted using filled circles with their meta-analysis P values (as −log<sub>10</sub> values) as a function of genomic position (NCBI Build 35). In each plot, the discovery stage SNP taken forward to replication stage is represented by a blue diamond (defining a global meta-analysis <italic>P</italic> value), with its discovery meta-analysis <italic>P</italic> value denoted by a red diamond. Local LD structure is reflected by the plotted estimated recombination rates (taken from HapMap) in the region around the associated SNPs and their correlated proxies. Each analyzed SNP is represented by circle. The colour scheme of the circles respects LD patterns (HapMap CEU pair-wise r2 correlation coefficients) between top discovery SNP and surrounding variants: white r2<0.2, grey 0.5> r2 >= 0.2, orange 0.8> r2 >= 0.5, red r2 >= 0.8. Gene annotations were taken from the University of California Santa Cruz genome browser.</p></caption><graphic xlink:href="ukmss-29218-f0001"></graphic><graphic xlink:href="ukmss-29218-f0002"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p>Forest plots of the association between birth weight and genotype at each locus.</p><p><bold>[A]</bold> Index SNP rs900400 at 3q25.</p><p><bold>[B]</bold> Index SNP rs9883204 at 3q21.</p><p>If the index SNP was unavailable, a closely-correlated proxy (HapMap r<sup>2</sup>>0.9) was used.</p></caption><graphic xlink:href="ukmss-29218-f0003"></graphic><graphic xlink:href="ukmss-29218-f0004"></graphic></fig><table-wrap id="T1" position="float" orientation="landscape"><label>Table 1</label><caption><p>Associations between novel birth weight loci and anthropometric traits at birth</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="middle" rowspan="1" colspan="1">Phenotype</th><th colspan="4" align="center" valign="middle" rowspan="1">Locus 3q25, nearest genes: <italic>CCNL1, LEKR1</italic><xref ref-type="table-fn" rid="TFN1">a</xref></th><th colspan="4" align="center" valign="middle" rowspan="1">Locus 3q21, <italic>ADCY5</italic><xref ref-type="table-fn" rid="TFN2">b</xref></th></tr></thead><tbody><tr><td align="left" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">N</td><td align="center" valign="middle" rowspan="1" colspan="1">Effect</td><td align="center" valign="middle" rowspan="1" colspan="1">95%CI</td><td align="center" valign="middle" rowspan="1" colspan="1"><italic>P</italic> value<xref ref-type="table-fn" rid="TFN3">c</xref></td><td align="center" valign="middle" rowspan="1" colspan="1">N</td><td align="center" valign="middle" rowspan="1" colspan="1">Effect</td><td align="center" valign="middle" rowspan="1" colspan="1">95%CI</td><td align="center" valign="middle" rowspan="1" colspan="1"><italic>P</italic> value<xref ref-type="table-fn" rid="TFN3">c</xref></td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Birth weight Z-score<xref ref-type="table-fn" rid="TFN4">d</xref></td><td align="center" valign="middle" rowspan="1" colspan="1">37745</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.086<break></break> SD</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.100, −0.073</td><td align="center" valign="middle" rowspan="1" colspan="1">2×10<sup>−35</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">38214</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.063<break></break> SD</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.079, −0.047</td><td align="center" valign="middle" rowspan="1" colspan="1">7×10<sup>−15</sup></td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Birth length Z-score</td><td align="center" valign="middle" rowspan="1" colspan="1">21512</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.028<break></break> SD</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.046, −0.010</td><td align="center" valign="middle" rowspan="1" colspan="1">0.002</td><td align="center" valign="middle" rowspan="1" colspan="1">21782</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.044<break></break> SD</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.066, −0.022</td><td align="center" valign="middle" rowspan="1" colspan="1">4×10<sup>−5</sup></td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Birth head circumference Z-score</td><td align="center" valign="middle" rowspan="1" colspan="1">17349</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.024<break></break> SD</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.044, −0.004</td><td align="center" valign="middle" rowspan="1" colspan="1">0.017</td><td align="center" valign="middle" rowspan="1" colspan="1">17693</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.025<break></break> SD</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.048, −0.004</td><td align="center" valign="middle" rowspan="1" colspan="1">0.030</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Ponderal index<xref ref-type="table-fn" rid="TFN5">e</xref> Z-score</td><td align="center" valign="middle" rowspan="1" colspan="1">21515</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.094<break></break> SD</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.113, −0.074</td><td align="center" valign="middle" rowspan="1" colspan="1">5×10<sup>−21</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">21785</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.032<break></break> SD</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.055, −0.009</td><td align="center" valign="middle" rowspan="1" colspan="1">0.006</td></tr><tr><td colspan="9" align="left" valign="middle" rowspan="1"><hr></hr></td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Odds ratio for SGA <10th<break></break> percentile<xref ref-type="table-fn" rid="TFN6">f</xref></td><td align="center" valign="middle" rowspan="1" colspan="1">30370</td><td align="center" valign="middle" rowspan="1" colspan="1">1.16</td><td align="center" valign="middle" rowspan="1" colspan="1">1.10, 1.23</td><td align="center" valign="middle" rowspan="1" colspan="1">1×10<sup>−7</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">30778</td><td align="center" valign="middle" rowspan="1" colspan="1">1.09</td><td align="center" valign="middle" rowspan="1" colspan="1">1.02, 1.16</td><td align="center" valign="middle" rowspan="1" colspan="1">0.009</td></tr></tbody></table><table-wrap-foot><p>Results are from inverse variance, fixed effects meta-analysis of all 19 study samples of European ancestry. The effect allele for each SNP is labelled on the positive strand according to HapMap. The effect is the beta coefficient (or odds ratio) for genotype, assuming an additive genetic model. If the index SNP was unavailable, this was substituted with a closely-correlated (HapMap r<sup>2</sup>>0.9) proxy (rs1482853 or rs900399 for rs900400; rs2877716 or rs6798189 for rs9883204). There was no evidence of between-study heterogeneity of effect size estimates (all <italic>P</italic>>0.18; <italic>I</italic><sup>2</sup><26%).</p><fn id="TFN1"><label>a</label><p id="P37">Index SNP rs900400, effect allele C (40% frequency in HapMap CEU; range 32-47% in our European study samples).</p></fn><fn id="TFN2"><label>b</label><p id="P38">Index SNP rs9883204, effect allele C (73% frequency in HapMap CEU; range 71-83% in our European study samples).</p></fn><fn id="TFN3"><label>c</label><p id="P39">The <italic>P</italic> value for the birth weight meta-analysis includes the double-GC correction of the discovery meta-analysis.</p></fn><fn id="TFN4"><label>d</label><p id="P40">Excluding the three studies that were unable to adjust for gestational age, the beta (s.e.m.), N and <italic>P</italic> values in the birth weight analysis were: −0.089(0.008), N=31510, <italic>P</italic>=7×10<sup>−32</sup> (3q25); −0.068(0.009), N=31901, <italic>P</italic>=8×10<sup>−15</sup> (3q21).</p></fn><fn id="TFN5"><label>e</label><p id="P41">Ponderal index = birth weight/length<sup>3</sup>.</p></fn><fn id="TFN6"><label>f</label><p id="P42">SGA <5<sup>th</sup> percentile, OR (<italic>P</italic> value): rs900400=1.11 (0.004); rs9883204=1.04 (0.41).</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" position="float" orientation="landscape"><label>Table 2</label><caption><p>Mean birth weight (SD) by genotype and individual association results by study</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="5" align="left" valign="middle" colspan="1">Study type</th><th rowspan="5" align="left" valign="middle" colspan="1">Study</th><th rowspan="5" align="center" valign="middle" colspan="1">Year(s)<break></break> of birth</th><th rowspan="5" align="center" valign="middle" colspan="1">Total<break></break> N<xref ref-type="table-fn" rid="TFN7">a</xref></th><th rowspan="5" align="center" valign="middle" colspan="1">%<break></break> mal<break></break> e</th><th colspan="4" align="center" valign="middle" rowspan="1">Locus 3q25, nearest genes: <italic>CCNL1</italic>, <italic>LEKR1</italic><xref ref-type="table-fn" rid="TFN8">b</xref></th><th colspan="4" align="center" valign="middle" rowspan="1">Locus 3q21, <italic>ADCY5</italic><xref ref-type="table-fn" rid="TFN8">b</xref></th></tr><tr><th colspan="8" align="center" valign="middle" rowspan="1"><hr></hr></th></tr><tr><th align="center" valign="middle" rowspan="1" colspan="1">TT</th><th align="center" valign="middle" rowspan="1" colspan="1">CT</th><th align="center" valign="middle" rowspan="1" colspan="1">CC</th><th rowspan="3" align="center" valign="middle" colspan="1"><italic>P</italic><break></break> value<xref ref-type="table-fn" rid="TFN9">c</xref></th><th align="center" valign="middle" rowspan="1" colspan="1">TT</th><th align="center" valign="middle" rowspan="1" colspan="1">CT</th><th align="center" valign="middle" rowspan="1" colspan="1">CC</th><th rowspan="3" align="center" valign="middle" colspan="1"><italic>P</italic><break></break> value<xref ref-type="table-fn" rid="TFN9">c</xref></th></tr><tr><th colspan="3" align="center" valign="middle" rowspan="1"><hr></hr></th><th colspan="3" align="center" valign="middle" rowspan="1"><hr></hr></th></tr><tr><th align="center" valign="middle" rowspan="1" colspan="1">Mean BW<break></break> in g (SD)</th><th align="center" valign="middle" rowspan="1" colspan="1">Mean BW<break></break> in g (SD)</th><th align="center" valign="middle" rowspan="1" colspan="1">Mean BW<break></break> in g (SD)</th><th align="center" valign="middle" rowspan="1" colspan="1">Mean BW<break></break> in g (SD)</th><th align="center" valign="middle" rowspan="1" colspan="1">Mean BW<break></break> in g (SD)</th><th align="center" valign="middle" rowspan="1" colspan="1">Mean BW<break></break> in g (SD)</th></tr></thead><tbody><tr><td rowspan="6" align="left" valign="middle" colspan="1">Discovery</td><td align="left" valign="middle" rowspan="1" colspan="1">NTR</td><td align="center" valign="middle" rowspan="1" colspan="1">1923-86</td><td align="center" valign="middle" rowspan="1" colspan="1">414</td><td align="center" valign="middle" rowspan="1" colspan="1">37.9</td><td align="center" valign="middle" rowspan="1" colspan="1">3470 (652)</td><td align="center" valign="middle" rowspan="1" colspan="1">3401 (615)</td><td align="center" valign="middle" rowspan="1" colspan="1">3329 (646)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.08</td><td align="center" valign="middle" rowspan="1" colspan="1">3500 (720)</td><td align="center" valign="middle" rowspan="1" colspan="1">3402 (604)</td><td align="center" valign="middle" rowspan="1" colspan="1">3359 (633)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.09</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">B58C-WTCCC</td><td align="center" valign="middle" rowspan="1" colspan="1">1958</td><td align="center" valign="middle" rowspan="1" colspan="1">1227</td><td align="center" valign="middle" rowspan="1" colspan="1">50.4</td><td align="center" valign="middle" rowspan="1" colspan="1">3367 (444)</td><td align="center" valign="middle" rowspan="1" colspan="1">3337 (455)</td><td align="center" valign="middle" rowspan="1" colspan="1">3364 (454)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.77</td><td align="center" valign="middle" rowspan="1" colspan="1">3459 (457)</td><td align="center" valign="middle" rowspan="1" colspan="1">3357 (456)</td><td align="center" valign="middle" rowspan="1" colspan="1">3336 (455)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.05</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">B58C-T1DGC</td><td align="center" valign="middle" rowspan="1" colspan="1">1958</td><td align="center" valign="middle" rowspan="1" colspan="1">2037</td><td align="center" valign="middle" rowspan="1" colspan="1">49.2</td><td align="center" valign="middle" rowspan="1" colspan="1">3399 (468)</td><td align="center" valign="middle" rowspan="1" colspan="1">3339 (464)</td><td align="center" valign="middle" rowspan="1" colspan="1">3308 (461)</td><td align="center" valign="middle" rowspan="1" colspan="1">1×10<sup>−3</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">3396 (463)</td><td align="center" valign="middle" rowspan="1" colspan="1">3375 (484)</td><td align="center" valign="middle" rowspan="1" colspan="1">3341 (463)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.07</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">NFBC1966</td><td align="center" valign="middle" rowspan="1" colspan="1">1966</td><td align="center" valign="middle" rowspan="1" colspan="1">4333</td><td align="center" valign="middle" rowspan="1" colspan="1">48.1</td><td align="center" valign="middle" rowspan="1" colspan="1">3567 (458)</td><td align="center" valign="middle" rowspan="1" colspan="1">3519 (458)</td><td align="center" valign="middle" rowspan="1" colspan="1">3503 (458)</td><td align="center" valign="middle" rowspan="1" colspan="1">5×10<sup>−4</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">3630 (459)</td><td align="center" valign="middle" rowspan="1" colspan="1">3559 (459)</td><td align="center" valign="middle" rowspan="1" colspan="1">3529 (459)</td><td align="center" valign="middle" rowspan="1" colspan="1">4×10<sup>−3</sup></td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">ALSPAC (D)</td><td align="center" valign="middle" rowspan="1" colspan="1">1991-2</td><td align="center" valign="middle" rowspan="1" colspan="1">1418</td><td align="center" valign="middle" rowspan="1" colspan="1">48.8</td><td align="center" valign="middle" rowspan="1" colspan="1">3486 (481)</td><td align="center" valign="middle" rowspan="1" colspan="1">3419 (482)</td><td align="center" valign="middle" rowspan="1" colspan="1">3374 (467)</td><td align="center" valign="middle" rowspan="1" colspan="1">2×10<sup>−3</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">3451 (458)</td><td align="center" valign="middle" rowspan="1" colspan="1">3462 (465)</td><td align="center" valign="middle" rowspan="1" colspan="1">3405 (514)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.03</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Generation R<break></break> (D)</td><td align="center" valign="middle" rowspan="1" colspan="1">2002-6</td><td align="center" valign="middle" rowspan="1" colspan="1">1194</td><td align="center" valign="middle" rowspan="1" colspan="1">53.1</td><td align="center" valign="middle" rowspan="1" colspan="1">3633 (435)</td><td align="center" valign="middle" rowspan="1" colspan="1">3562 (447)</td><td align="center" valign="middle" rowspan="1" colspan="1">3492 (448)</td><td align="center" valign="middle" rowspan="1" colspan="1">1×10<sup>−4</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">3655 (449)</td><td align="center" valign="middle" rowspan="1" colspan="1">3593 (444)</td><td align="center" valign="middle" rowspan="1" colspan="1">3549 (456)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.01</td></tr><tr><td colspan="13" align="left" valign="middle" rowspan="1"><hr></hr></td></tr><tr><td rowspan="13" align="left" valign="middle" colspan="1">Replication</td><td align="left" valign="middle" rowspan="1" colspan="1">ORCADES</td><td align="center" valign="middle" rowspan="1" colspan="1">1920-88</td><td align="center" valign="middle" rowspan="1" colspan="1">328</td><td align="center" valign="middle" rowspan="1" colspan="1">43.3</td><td align="center" valign="middle" rowspan="1" colspan="1">3635 (599)</td><td align="center" valign="middle" rowspan="1" colspan="1">3615 (594)</td><td align="center" valign="middle" rowspan="1" colspan="1">3487 (602)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.12</td><td align="center" valign="middle" rowspan="1" colspan="1">3542 (612)</td><td align="center" valign="middle" rowspan="1" colspan="1">3670 (605)</td><td align="center" valign="middle" rowspan="1" colspan="1">3566 (595)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.74</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">HBCS</td><td align="center" valign="middle" rowspan="1" colspan="1">1934-44</td><td align="center" valign="middle" rowspan="1" colspan="1">1566</td><td align="center" valign="middle" rowspan="1" colspan="1">42.7</td><td align="center" valign="middle" rowspan="1" colspan="1">3462 (436)</td><td align="center" valign="middle" rowspan="1" colspan="1">3434 (438)</td><td align="center" valign="middle" rowspan="1" colspan="1">3403 (430)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.06</td><td align="center" valign="middle" rowspan="1" colspan="1">3391 (426)</td><td align="center" valign="middle" rowspan="1" colspan="1">3479 (434)</td><td align="center" valign="middle" rowspan="1" colspan="1">3431 (418)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.33</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">B58C (R)</td><td align="center" valign="middle" rowspan="1" colspan="1">1958</td><td align="center" valign="middle" rowspan="1" colspan="1">2550</td><td align="center" valign="middle" rowspan="1" colspan="1">51.6</td><td align="center" valign="middle" rowspan="1" colspan="1">3407 (454)</td><td align="center" valign="middle" rowspan="1" colspan="1">3341 (451)</td><td align="center" valign="middle" rowspan="1" colspan="1">3308 (456)</td><td align="center" valign="middle" rowspan="1" colspan="1">7×10<sup>−5</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">3338 (457)</td><td align="center" valign="middle" rowspan="1" colspan="1">3387 (448)</td><td align="center" valign="middle" rowspan="1" colspan="1">3340 (477)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.14</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">NFBC1986</td><td align="center" valign="middle" rowspan="1" colspan="1">1985-6</td><td align="center" valign="middle" rowspan="1" colspan="1">5008</td><td align="center" valign="middle" rowspan="1" colspan="1">49.1</td><td align="center" valign="middle" rowspan="1" colspan="1">3656 (440)</td><td align="center" valign="middle" rowspan="1" colspan="1">3607 (440)</td><td align="center" valign="middle" rowspan="1" colspan="1">3591 (440)</td><td align="center" valign="middle" rowspan="1" colspan="1">4×10<sup>−5</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">3674 (441)</td><td align="center" valign="middle" rowspan="1" colspan="1">3646 (441)</td><td align="center" valign="middle" rowspan="1" colspan="1">3620 (441)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.03</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">CHOP</td><td align="center" valign="middle" rowspan="1" colspan="1">1987-<break></break>2009</td><td align="center" valign="middle" rowspan="1" colspan="1">5149</td><td align="center" valign="middle" rowspan="1" colspan="1">53.3</td><td align="center" valign="middle" rowspan="1" colspan="1">3384 (634)</td><td align="center" valign="middle" rowspan="1" colspan="1">3333 (646)</td><td align="center" valign="middle" rowspan="1" colspan="1">3318 (628)</td><td align="center" valign="middle" rowspan="1" colspan="1">5×10<sup>−3</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">3389 (641)</td><td align="center" valign="middle" rowspan="1" colspan="1">3357 (647)</td><td align="center" valign="middle" rowspan="1" colspan="1">3341 (609)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.19</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">RAINE</td><td align="center" valign="middle" rowspan="1" colspan="1">1989-92</td><td align="center" valign="middle" rowspan="1" colspan="1">988</td><td align="center" valign="middle" rowspan="1" colspan="1">52.4</td><td align="center" valign="middle" rowspan="1" colspan="1">3507 (428)</td><td align="center" valign="middle" rowspan="1" colspan="1">3432 (417)</td><td align="center" valign="middle" rowspan="1" colspan="1">3384 (429)</td><td align="center" valign="middle" rowspan="1" colspan="1">1×10<sup>−3</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">3472 (426)</td><td align="center" valign="middle" rowspan="1" colspan="1">3489 (431)</td><td align="center" valign="middle" rowspan="1" colspan="1">3427 (425)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.06</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">ALSPAC (R)</td><td align="center" valign="middle" rowspan="1" colspan="1">1991-2</td><td align="center" valign="middle" rowspan="1" colspan="1">5695</td><td align="center" valign="middle" rowspan="1" colspan="1">54.6</td><td align="center" valign="middle" rowspan="1" colspan="1">3303 (547)</td><td align="center" valign="middle" rowspan="1" colspan="1">3259 (568)</td><td align="center" valign="middle" rowspan="1" colspan="1">3229 (493)</td><td align="center" valign="middle" rowspan="1" colspan="1">3×10<sup>−6</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">3305 (464)</td><td align="center" valign="middle" rowspan="1" colspan="1">3288 (580)</td><td align="center" valign="middle" rowspan="1" colspan="1">3257 (626)</td><td align="center" valign="middle" rowspan="1" colspan="1">3×10<sup>−3</sup></td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">GENDAI</td><td align="center" valign="middle" rowspan="1" colspan="1">1994-6</td><td align="center" valign="middle" rowspan="1" colspan="1">758</td><td align="center" valign="middle" rowspan="1" colspan="1">45.5</td><td align="center" valign="middle" rowspan="1" colspan="1">3401 (530)</td><td align="center" valign="middle" rowspan="1" colspan="1">3215 (528)</td><td align="center" valign="middle" rowspan="1" colspan="1">3235 (529)</td><td align="center" valign="middle" rowspan="1" colspan="1">1×10<sup>−3</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">3291 (539)</td><td align="center" valign="middle" rowspan="1" colspan="1">3286 (539)</td><td align="center" valign="middle" rowspan="1" colspan="1">3260 (539)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.53</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">PIAMA</td><td align="center" valign="middle" rowspan="1" colspan="1">1996-7</td><td align="center" valign="middle" rowspan="1" colspan="1">1789</td><td align="center" valign="middle" rowspan="1" colspan="1">51.3</td><td align="center" valign="middle" rowspan="1" colspan="1">3629 (438)</td><td align="center" valign="middle" rowspan="1" colspan="1">3575 (443)</td><td align="center" valign="middle" rowspan="1" colspan="1">3512 (427)</td><td align="center" valign="middle" rowspan="1" colspan="1">9×10<sup>−5</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">3619 (441)</td><td align="center" valign="middle" rowspan="1" colspan="1">3607 (425)</td><td align="center" valign="middle" rowspan="1" colspan="1">3554 (430)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.01</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">LISA</td><td align="center" valign="middle" rowspan="1" colspan="1">1998-9</td><td align="center" valign="middle" rowspan="1" colspan="1">387</td><td align="center" valign="middle" rowspan="1" colspan="1">56.9</td><td align="center" valign="middle" rowspan="1" colspan="1">3476 (366)</td><td align="center" valign="middle" rowspan="1" colspan="1">3454 (363)</td><td align="center" valign="middle" rowspan="1" colspan="1">3368 (363)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.07</td><td align="center" valign="middle" rowspan="1" colspan="1">3532 (365)</td><td align="center" valign="middle" rowspan="1" colspan="1">3429 (366)</td><td align="center" valign="middle" rowspan="1" colspan="1">3443 (367)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.84</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">PROJECT VIVA</td><td align="center" valign="middle" rowspan="1" colspan="1">1999-<break></break>2003</td><td align="center" valign="middle" rowspan="1" colspan="1">300</td><td align="center" valign="middle" rowspan="1" colspan="1">50.0</td><td align="center" valign="middle" rowspan="1" colspan="1">3711 (406)</td><td align="center" valign="middle" rowspan="1" colspan="1">3646 (411)</td><td align="center" valign="middle" rowspan="1" colspan="1">3594 (407)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.08</td><td align="center" valign="middle" rowspan="1" colspan="1">3698 (412)</td><td align="center" valign="middle" rowspan="1" colspan="1">3703 (402)</td><td align="center" valign="middle" rowspan="1" colspan="1">3625 (408)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.15</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Generation R (R)</td><td align="center" valign="middle" rowspan="1" colspan="1">2002-6</td><td align="center" valign="middle" rowspan="1" colspan="1">1885</td><td align="center" valign="middle" rowspan="1" colspan="1">50.3</td><td align="center" valign="middle" rowspan="1" colspan="1">3558 (435)</td><td align="center" valign="middle" rowspan="1" colspan="1">3527 (423)</td><td align="center" valign="middle" rowspan="1" colspan="1">3481 (413)</td><td align="center" valign="middle" rowspan="1" colspan="1">6×10<sup>−3</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">3615 (433)</td><td align="center" valign="middle" rowspan="1" colspan="1">3534 (435)</td><td align="center" valign="middle" rowspan="1" colspan="1">3518 (430)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.04</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">EFSOCH</td><td align="center" valign="middle" rowspan="1" colspan="1">2003-4</td><td align="center" valign="middle" rowspan="1" colspan="1">719</td><td align="center" valign="middle" rowspan="1" colspan="1">53.1</td><td align="center" valign="middle" rowspan="1" colspan="1">3556 (427)</td><td align="center" valign="middle" rowspan="1" colspan="1">3509 (432)</td><td align="center" valign="middle" rowspan="1" colspan="1">3504 (431)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.20</td><td align="center" valign="middle" rowspan="1" colspan="1">3660 (433)</td><td align="center" valign="middle" rowspan="1" colspan="1">3513 (435)</td><td align="center" valign="middle" rowspan="1" colspan="1">3503 (432)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.07</td></tr></tbody></table><table-wrap-foot><p>BW, birth weight. All birth weight values are adjusted for sex and, where available, gestational age. Gestational age was not available for the ORCADES, CHOP and GENDAI studies.</p><fn id="TFN7"><label>a</label><p id="P43">Study N in the birth weight association analysis for rs900400 genotype. Total numbers of European discovery and replication samples, respectively, were N=10623 and N=27122 for rs900400; N=10623 and N=27591 for rs9883204.</p></fn><fn id="TFN8"><label>b</label><p id="P44">If the index SNP was unavailable, this was substituted with a closely-correlated (HapMap r<sup>2</sup>>0.9) proxy (rs1482853 or rs900399 for rs900400 at 3q25; rs2877716 or rs6798189 for rs9883204 at 3q21).</p></fn><fn id="TFN9"><label>c</label><p id="P45"><italic>P</italic> value is from linear regression of birth weight Z score against SNP (additive model), with sex and gestational age, where available, as covariates. All study samples were of European descent.</p></fn><p><bold>Key to study names:</bold> NTR, Netherlands Twin Register; B58C-WTCCC, British 1958 Birth Cohort – Wellcome Trust Case Control Consortium subset; B58C-T1DGC, British 1958 Birth Cohort – Type 1 Diabetes Genetics Consortium subset; NFBC1966, Northern Finland Birth Cohort 1966; ALSPAC (D), Avon Longitudinal Study of Parents and Children Discovery subset; Generation R (D), Generation R Discovery subset; ORCADES, Orkney Complex Disease Study; HBCS, Helsinki Birth Cohort Study; B58C (R), British 1958 Birth Cohort Replication subset; NFBC1986, Northern Finland Birth Cohort 1986; CHOP, Children's Hospital Of Philadelphia; RAINE, The Raine Study; ALSPAC (R), Avon Longitudinal Study of Parents and Children Replication subset; GENDAI, GENe and Diet Attica Investigation; PIAMA, Prevention and Incidence of Asthma and Mite Allergy; LISA, Lifestyle – Immune System – Allergy; Project Viva, The Project Viva Cohort; Generation R (R), Generation R Replication subset; EFSOCH, Exeter Family Study Of Childhood Health.</p></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>Allemagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Pays-Bas</li><li>Philippines</li><li>Royaume-Uni</li><li>Thaïlande</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Attique(région)</li><li>Bavière</li><li>Caroline du Nord</li><li>District de Haute-Bavière</li><li>Grand Londres</li><li>Groningue (province)</li><li>Hauts-de-France</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Massachusetts</li><li>Nord-Pas-de-Calais</li><li>Oxfordshire</li><li>Uusimaa</li><li>Écosse</li></region><settlement><li>Amsterdam</li><li>Athènes</li><li>Groningue</li><li>Groningue (ville)</li><li>Helsinki</li><li>Kallithéa</li><li>Lille</li><li>Londres</li><li>Munich</li><li>Oxford</li><li>Rotterdam</li><li>Édimbourg</li></settlement><orgName><li>Université Harokopio</li><li>Université Louis-et-Maximilien de Munich</li><li>Université d'Helsinki</li><li>Université d'Oxford</li><li>Université d'Édimbourg</li><li>Université de Groningue</li><li>Université de Londres</li></orgName></list><tree><noCountry><name sortKey="Marsh, Julie A" sort="Marsh, Julie A" uniqKey="Marsh J" first="Julie A" last="Marsh">Julie A. Marsh</name><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E" last="Pennell">Craig E. Pennell</name><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M" last="Warrington">Nicole M. Warrington</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Freathy, Rachel M" sort="Freathy, Rachel M" uniqKey="Freathy R" first="Rachel M" last="Freathy">Rachel M. Freathy</name></noRegion><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J" last="Bennett">Amanda J. Bennett</name><name sortKey="Berry, Diane J" sort="Berry, Diane J" uniqKey="Berry D" first="Diane J" last="Berry">Diane J. Berry</name><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><name sortKey="Coin, Lachlan J M" sort="Coin, Lachlan J M" uniqKey="Coin L" first="Lachlan J M" last="Coin">Lachlan J M. Coin</name><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><name sortKey="Frayling, Timothy M" sort="Frayling, Timothy M" uniqKey="Frayling T" first="Timothy M" last="Frayling">Timothy M. Frayling</name><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><name sortKey="Glaser, Beate" sort="Glaser, Beate" uniqKey="Glaser B" first="Beate" last="Glaser">Beate Glaser</name><name sortKey="Glaser, Beate" sort="Glaser, Beate" uniqKey="Glaser B" first="Beate" last="Glaser">Beate Glaser</name><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J" last="Groves">Christopher J. Groves</name><name sortKey="Hassanali, Neelam" sort="Hassanali, Neelam" uniqKey="Hassanali N" first="Neelam" last="Hassanali">Neelam Hassanali</name><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T" last="Hattersley">Andrew T. Hattersley</name><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M P" last="Holly">Jeff M P. Holly</name><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name><name sortKey="Knight, Bridget A" sort="Knight, Bridget A" uniqKey="Knight B" first="Bridget A" last="Knight">Bridget A. Knight</name><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M" last="Lindgren">Cecilia M. Lindgren</name><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M" last="Lindgren">Cecilia M. Lindgren</name><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name><name sortKey="O Reilly, Paul F" sort="O Reilly, Paul F" uniqKey="O Reilly P" first="Paul F" last="O'Reilly">Paul F. O'Reilly</name><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W" last="Rayner">Nigel W. Rayner</name><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W" last="Rayner">Nigel W. Rayner</name><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M" last="Ring">Susan M. Ring</name><name sortKey="Shields, Beverley M" sort="Shields, Beverley M" uniqKey="Shields B" first="Beverley M" last="Shields">Beverley M. Shields</name><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name></region><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S" last="Aulchenko">Yurii S. Aulchenko</name><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke Jan" last="Hottenga">Jouke Jan Hottenga</name><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W V" last="Jaddoe">Vincent W V. Jaddoe</name><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W V" last="Jaddoe">Vincent W V. Jaddoe</name><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H" last="Koppelman">Gerard H. Koppelman</name><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S" last="Postma">Dirkje S. Postma</name><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A P" last="Steegers">Eric A P. Steegers</name><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><name sortKey="Wijga, Alet H" sort="Wijga, Alet H" uniqKey="Wijga A" first="Alet H" last="Wijga">Alet H. Wijga</name><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name></region><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L" last="Cousminer">Diana L. Cousminer</name><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><name sortKey="Taanila, Anja" sort="Taanila, Anja" uniqKey="Taanila A" first="Anja" last="Taanila">Anja Taanila</name></country><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A" last="Lange">Leslie A. Lange</name></region><name sortKey="Adair, Linda S" sort="Adair, Linda S" uniqKey="Adair L" first="Linda S" last="Adair">Linda S. Adair</name><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P" last="Bradfield">Jonathan P. Bradfield</name><name sortKey="Gillman, Matthew W" sort="Gillman, Matthew W" uniqKey="Gillman M" first="Matthew W" last="Gillman">Matthew W. Gillman</name><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F A" last="Grant">Struan F A. Grant</name><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F A" last="Grant">Struan F A. Grant</name><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F A" last="Grant">Struan F A. Grant</name><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N" last="Hirschhorn">Joel N. Hirschhorn</name><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N" last="Hirschhorn">Joel N. Hirschhorn</name><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N" last="Hirschhorn">Joel N. Hirschhorn</name><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N" last="Hirschhorn">Joel N. Hirschhorn</name><name sortKey="Lyon, Helen N" sort="Lyon, Helen N" uniqKey="Lyon H" first="Helen N" last="Lyon">Helen N. Lyon</name><name sortKey="Lyon, Helen N" sort="Lyon, Helen N" uniqKey="Lyon H" first="Helen N" last="Lyon">Helen N. Lyon</name><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L" last="Mohlke">Karen L. Mohlke</name><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><name sortKey="Zhang, Haitao" sort="Zhang, Haitao" uniqKey="Zhang H" first="Haitao" last="Zhang">Haitao Zhang</name><name sortKey="Zhao, Jianhua" sort="Zhao, Jianhua" uniqKey="Zhao J" first="Jianhua" last="Zhao">Jianhua Zhao</name></country><country name="Allemagne"><noRegion><name sortKey="Chen, Chih Mei" sort="Chen, Chih Mei" uniqKey="Chen C" first="Chih-Mei" last="Chen">Chih-Mei Chen</name></noRegion><name sortKey="Chen, Chih Mei" sort="Chen, Chih Mei" uniqKey="Chen C" first="Chih-Mei" last="Chen">Chih-Mei Chen</name><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name></country><country name="Philippines"><noRegion><name sortKey="Borja, Judith B" sort="Borja, Judith B" uniqKey="Borja J" first="Judith B" last="Borja">Judith B. Borja</name></noRegion></country><country name="France"><region name="Hauts-de-France"><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name></region><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name></country><country name="Thaïlande"><noRegion><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name></noRegion></country><country name="Grèce"><region name="Attique(région)"><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name></region><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V" last="Dedoussis">George V. Dedoussis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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