Genome-wide association study using a high-density SNP-array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of eNOS
Identifieur interne : 002298 ( Pmc/Checkpoint ); précédent : 002297; suivant : 002299Genome-wide association study using a high-density SNP-array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of eNOS
Auteurs : Erika Salvi ; Zoltán Kutalik ; Nicola Glorioso ; Paola Benaglio ; Francesca Frau ; Tatiana Kuznetsova ; Hisatomi Arima ; Clive Hoggart ; Jean Tichet ; Yury P. Nikitin ; Costanza Conti ; Jitka Seidlerova ; Valérie Tikhonoff ; Katarzyna Stolarz-Skrzypek ; Toby Johnson ; Nabila Devos ; Laura Zagato ; Simonetta Guarrera ; Roberta Zaninello ; Andrea Calabria ; Benedetta Stancanelli ; Chiara Troffa ; Lutgarde Thijs ; Federica Rizzi ; Galina Simonova ; Sara Lupoli ; Giuseppe Argiolas ; Daniele Braga ; Maria C. D Lessio ; Maria F. Ortu ; Fulvio Ricceri ; Maurizio Mercurio ; Patrick Descombes ; Maurizio Marconi ; John Chalmers ; Stephen Harrap ; Jan Filipovsky ; Murielle Bochud ; Licia Iacoviello ; Justine Ellis ; Alice V. Stanton ; Maris Laan ; Sandosh Padmanabhan ; Anna F. Dominiczak ; Nilesh J. Samani ; Olle Melander ; Xavier Jeunemaitre ; Paolo Manunta ; Amnon Shabo ; Paolo Vineis ; Francesco P. Cappuccio ; Mark J. Caulfield ; Giuseppe Matullo ; Carlo Rivolta ; Patricia B. Munroe ; Cristina Barlassina ; Jan A. Staessen ; Jacques S. Beckmann ; Daniele CusiSource :
- Hypertension [ 0194-911X ] ; 2011.
Abstract
Essential hypertension is a multi-factorial disorder and is the main risk factor for renal and cardiovascular complications. The research on the genetics of hypertension has been frustrated by the small predictive value of the discovered genetic variants. The HYPERGENES Project investigated associations between genetic variants and essential hypertension pursuing a two-stage study by recruiting cases and controls from extensively characterized cohorts recruited over many years in different European regions.
The discovery phase consisted of 1,865 cases and 1,750 controls genotyped with 1M Illumina array. Best hits were followed up in a validation panel of 1,385 cases and 1,246 controls that were genotyped with a custom array of 14,055 markers. We identified a new hypertension susceptibility locus (rs3918226) in the promoter region of the endothelial nitric oxide synthase (eNOS) gene (odds ratio 1.54; 95% CI 1.37-1.73; combined p=2.58·10−13). A meta-analysis, using other
Url:
DOI: 10.1161/HYPERTENSIONAHA.111.181990
PubMed: 22184326
PubMed Central: 3272453
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide association study using a high-density SNP-array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of <italic>eNOS</italic></title><author><name sortKey="Salvi, Erika" sort="Salvi, Erika" uniqKey="Salvi E" first="Erika" last="Salvi">Erika Salvi</name></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name></author><author><name sortKey="Glorioso, Nicola" sort="Glorioso, Nicola" uniqKey="Glorioso N" first="Nicola" last="Glorioso">Nicola Glorioso</name></author><author><name sortKey="Benaglio, Paola" sort="Benaglio, Paola" uniqKey="Benaglio P" first="Paola" last="Benaglio">Paola Benaglio</name></author><author><name sortKey="Frau, Francesca" sort="Frau, Francesca" uniqKey="Frau F" first="Francesca" last="Frau">Francesca Frau</name></author><author><name sortKey="Kuznetsova, Tatiana" sort="Kuznetsova, Tatiana" uniqKey="Kuznetsova T" first="Tatiana" last="Kuznetsova">Tatiana Kuznetsova</name></author><author><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name></author><author><name sortKey="Hoggart, Clive" sort="Hoggart, Clive" uniqKey="Hoggart C" first="Clive" last="Hoggart">Clive Hoggart</name></author><author><name sortKey="Tichet, Jean" sort="Tichet, Jean" uniqKey="Tichet J" first="Jean" last="Tichet">Jean Tichet</name></author><author><name sortKey="Nikitin, Yury P" sort="Nikitin, Yury P" uniqKey="Nikitin Y" first="Yury P." last="Nikitin">Yury P. Nikitin</name></author><author><name sortKey="Conti, Costanza" sort="Conti, Costanza" uniqKey="Conti C" first="Costanza" last="Conti">Costanza Conti</name></author><author><name sortKey="Seidlerova, Jitka" sort="Seidlerova, Jitka" uniqKey="Seidlerova J" first="Jitka" last="Seidlerova">Jitka Seidlerova</name></author><author><name sortKey="Tikhonoff, Valerie" sort="Tikhonoff, Valerie" uniqKey="Tikhonoff V" first="Valérie" last="Tikhonoff">Valérie Tikhonoff</name></author><author><name sortKey="Stolarz Skrzypek, Katarzyna" sort="Stolarz Skrzypek, Katarzyna" uniqKey="Stolarz Skrzypek K" first="Katarzyna" last="Stolarz-Skrzypek">Katarzyna Stolarz-Skrzypek</name></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name></author><author><name sortKey="Devos, Nabila" sort="Devos, Nabila" uniqKey="Devos N" first="Nabila" last="Devos">Nabila Devos</name></author><author><name sortKey="Zagato, Laura" sort="Zagato, Laura" uniqKey="Zagato L" first="Laura" last="Zagato">Laura Zagato</name></author><author><name sortKey="Guarrera, Simonetta" sort="Guarrera, Simonetta" uniqKey="Guarrera S" first="Simonetta" last="Guarrera">Simonetta Guarrera</name></author><author><name sortKey="Zaninello, Roberta" sort="Zaninello, Roberta" uniqKey="Zaninello R" first="Roberta" last="Zaninello">Roberta Zaninello</name></author><author><name sortKey="Calabria, Andrea" sort="Calabria, Andrea" uniqKey="Calabria A" first="Andrea" last="Calabria">Andrea Calabria</name></author><author><name sortKey="Stancanelli, Benedetta" sort="Stancanelli, Benedetta" uniqKey="Stancanelli B" first="Benedetta" last="Stancanelli">Benedetta Stancanelli</name></author><author><name sortKey="Troffa, Chiara" sort="Troffa, Chiara" uniqKey="Troffa C" first="Chiara" last="Troffa">Chiara Troffa</name></author><author><name sortKey="Thijs, Lutgarde" sort="Thijs, Lutgarde" uniqKey="Thijs L" first="Lutgarde" last="Thijs">Lutgarde Thijs</name></author><author><name sortKey="Rizzi, Federica" sort="Rizzi, Federica" uniqKey="Rizzi F" first="Federica" last="Rizzi">Federica Rizzi</name></author><author><name sortKey="Simonova, Galina" sort="Simonova, Galina" uniqKey="Simonova G" first="Galina" last="Simonova">Galina Simonova</name></author><author><name sortKey="Lupoli, Sara" sort="Lupoli, Sara" uniqKey="Lupoli S" first="Sara" last="Lupoli">Sara Lupoli</name></author><author><name sortKey="Argiolas, Giuseppe" sort="Argiolas, Giuseppe" uniqKey="Argiolas G" first="Giuseppe" last="Argiolas">Giuseppe Argiolas</name></author><author><name sortKey="Braga, Daniele" sort="Braga, Daniele" uniqKey="Braga D" first="Daniele" last="Braga">Daniele Braga</name></author><author><name sortKey="D Lessio, Maria C" sort="D Lessio, Maria C" uniqKey="D Lessio M" first="Maria C." last="D Lessio">Maria C. D Lessio</name></author><author><name sortKey="Ortu, Maria F" sort="Ortu, Maria F" uniqKey="Ortu M" first="Maria F." last="Ortu">Maria F. Ortu</name></author><author><name sortKey="Ricceri, Fulvio" sort="Ricceri, Fulvio" uniqKey="Ricceri F" first="Fulvio" last="Ricceri">Fulvio Ricceri</name></author><author><name sortKey="Mercurio, Maurizio" sort="Mercurio, Maurizio" uniqKey="Mercurio M" first="Maurizio" last="Mercurio">Maurizio Mercurio</name></author><author><name sortKey="Descombes, Patrick" sort="Descombes, Patrick" uniqKey="Descombes P" first="Patrick" last="Descombes">Patrick Descombes</name></author><author><name sortKey="Marconi, Maurizio" sort="Marconi, Maurizio" uniqKey="Marconi M" first="Maurizio" last="Marconi">Maurizio Marconi</name></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name></author><author><name sortKey="Harrap, Stephen" sort="Harrap, Stephen" uniqKey="Harrap S" first="Stephen" last="Harrap">Stephen Harrap</name></author><author><name sortKey="Filipovsky, Jan" sort="Filipovsky, Jan" uniqKey="Filipovsky J" first="Jan" last="Filipovsky">Jan Filipovsky</name></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name></author><author><name sortKey="Iacoviello, Licia" sort="Iacoviello, Licia" uniqKey="Iacoviello L" first="Licia" last="Iacoviello">Licia Iacoviello</name></author><author><name sortKey="Ellis, Justine" sort="Ellis, Justine" uniqKey="Ellis J" first="Justine" last="Ellis">Justine Ellis</name></author><author><name sortKey="Stanton, Alice V" sort="Stanton, Alice V" uniqKey="Stanton A" first="Alice V." last="Stanton">Alice V. Stanton</name></author><author><name sortKey="Laan, Maris" sort="Laan, Maris" uniqKey="Laan M" first="Maris" last="Laan">Maris Laan</name></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name></author><author><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F." last="Dominiczak">Anna F. Dominiczak</name></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name></author><author><name sortKey="Jeunemaitre, Xavier" sort="Jeunemaitre, Xavier" uniqKey="Jeunemaitre X" first="Xavier" last="Jeunemaitre">Xavier Jeunemaitre</name></author><author><name sortKey="Manunta, Paolo" sort="Manunta, Paolo" uniqKey="Manunta P" first="Paolo" last="Manunta">Paolo Manunta</name></author><author><name sortKey="Shabo, Amnon" sort="Shabo, Amnon" uniqKey="Shabo A" first="Amnon" last="Shabo">Amnon Shabo</name></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name></author><author><name sortKey="Cappuccio, Francesco P" sort="Cappuccio, Francesco P" uniqKey="Cappuccio F" first="Francesco P." last="Cappuccio">Francesco P. Cappuccio</name></author><author><name sortKey="Caulfield, Mark J" sort="Caulfield, Mark J" uniqKey="Caulfield M" first="Mark J." last="Caulfield">Mark J. Caulfield</name></author><author><name sortKey="Matullo, Giuseppe" sort="Matullo, Giuseppe" uniqKey="Matullo G" first="Giuseppe" last="Matullo">Giuseppe Matullo</name></author><author><name sortKey="Rivolta, Carlo" sort="Rivolta, Carlo" uniqKey="Rivolta C" first="Carlo" last="Rivolta">Carlo Rivolta</name></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B." last="Munroe">Patricia B. Munroe</name></author><author><name sortKey="Barlassina, Cristina" sort="Barlassina, Cristina" uniqKey="Barlassina C" first="Cristina" last="Barlassina">Cristina Barlassina</name></author><author><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A" last="Staessen">Jan A. Staessen</name></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name></author><author><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22184326</idno><idno type="pmc">3272453</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272453</idno><idno type="RBID">PMC:3272453</idno><idno type="doi">10.1161/HYPERTENSIONAHA.111.181990</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001F84</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F84</idno><idno type="wicri:Area/Pmc/Curation">001E38</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001E38</idno><idno type="wicri:Area/Pmc/Checkpoint">002298</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002298</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association study using a high-density SNP-array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of <italic>eNOS</italic></title><author><name sortKey="Salvi, Erika" sort="Salvi, Erika" uniqKey="Salvi E" first="Erika" last="Salvi">Erika Salvi</name></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name></author><author><name sortKey="Glorioso, Nicola" sort="Glorioso, Nicola" uniqKey="Glorioso N" first="Nicola" last="Glorioso">Nicola Glorioso</name></author><author><name sortKey="Benaglio, Paola" sort="Benaglio, Paola" uniqKey="Benaglio P" first="Paola" last="Benaglio">Paola Benaglio</name></author><author><name sortKey="Frau, Francesca" sort="Frau, Francesca" uniqKey="Frau F" first="Francesca" last="Frau">Francesca Frau</name></author><author><name sortKey="Kuznetsova, Tatiana" sort="Kuznetsova, Tatiana" uniqKey="Kuznetsova T" first="Tatiana" last="Kuznetsova">Tatiana Kuznetsova</name></author><author><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name></author><author><name sortKey="Hoggart, Clive" sort="Hoggart, Clive" uniqKey="Hoggart C" first="Clive" last="Hoggart">Clive Hoggart</name></author><author><name sortKey="Tichet, Jean" sort="Tichet, Jean" uniqKey="Tichet J" first="Jean" last="Tichet">Jean Tichet</name></author><author><name sortKey="Nikitin, Yury P" sort="Nikitin, Yury P" uniqKey="Nikitin Y" first="Yury P." last="Nikitin">Yury P. Nikitin</name></author><author><name sortKey="Conti, Costanza" sort="Conti, Costanza" uniqKey="Conti C" first="Costanza" last="Conti">Costanza Conti</name></author><author><name sortKey="Seidlerova, Jitka" sort="Seidlerova, Jitka" uniqKey="Seidlerova J" first="Jitka" last="Seidlerova">Jitka Seidlerova</name></author><author><name sortKey="Tikhonoff, Valerie" sort="Tikhonoff, Valerie" uniqKey="Tikhonoff V" first="Valérie" last="Tikhonoff">Valérie Tikhonoff</name></author><author><name sortKey="Stolarz Skrzypek, Katarzyna" sort="Stolarz Skrzypek, Katarzyna" uniqKey="Stolarz Skrzypek K" first="Katarzyna" last="Stolarz-Skrzypek">Katarzyna Stolarz-Skrzypek</name></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name></author><author><name sortKey="Devos, Nabila" sort="Devos, Nabila" uniqKey="Devos N" first="Nabila" last="Devos">Nabila Devos</name></author><author><name sortKey="Zagato, Laura" sort="Zagato, Laura" uniqKey="Zagato L" first="Laura" last="Zagato">Laura Zagato</name></author><author><name sortKey="Guarrera, Simonetta" sort="Guarrera, Simonetta" uniqKey="Guarrera S" first="Simonetta" last="Guarrera">Simonetta Guarrera</name></author><author><name sortKey="Zaninello, Roberta" sort="Zaninello, Roberta" uniqKey="Zaninello R" first="Roberta" last="Zaninello">Roberta Zaninello</name></author><author><name sortKey="Calabria, Andrea" sort="Calabria, Andrea" uniqKey="Calabria A" first="Andrea" last="Calabria">Andrea Calabria</name></author><author><name sortKey="Stancanelli, Benedetta" sort="Stancanelli, Benedetta" uniqKey="Stancanelli B" first="Benedetta" last="Stancanelli">Benedetta Stancanelli</name></author><author><name sortKey="Troffa, Chiara" sort="Troffa, Chiara" uniqKey="Troffa C" first="Chiara" last="Troffa">Chiara Troffa</name></author><author><name sortKey="Thijs, Lutgarde" sort="Thijs, Lutgarde" uniqKey="Thijs L" first="Lutgarde" last="Thijs">Lutgarde Thijs</name></author><author><name sortKey="Rizzi, Federica" sort="Rizzi, Federica" uniqKey="Rizzi F" first="Federica" last="Rizzi">Federica Rizzi</name></author><author><name sortKey="Simonova, Galina" sort="Simonova, Galina" uniqKey="Simonova G" first="Galina" last="Simonova">Galina Simonova</name></author><author><name sortKey="Lupoli, Sara" sort="Lupoli, Sara" uniqKey="Lupoli S" first="Sara" last="Lupoli">Sara Lupoli</name></author><author><name sortKey="Argiolas, Giuseppe" sort="Argiolas, Giuseppe" uniqKey="Argiolas G" first="Giuseppe" last="Argiolas">Giuseppe Argiolas</name></author><author><name sortKey="Braga, Daniele" sort="Braga, Daniele" uniqKey="Braga D" first="Daniele" last="Braga">Daniele Braga</name></author><author><name sortKey="D Lessio, Maria C" sort="D Lessio, Maria C" uniqKey="D Lessio M" first="Maria C." last="D Lessio">Maria C. D Lessio</name></author><author><name sortKey="Ortu, Maria F" sort="Ortu, Maria F" uniqKey="Ortu M" first="Maria F." last="Ortu">Maria F. Ortu</name></author><author><name sortKey="Ricceri, Fulvio" sort="Ricceri, Fulvio" uniqKey="Ricceri F" first="Fulvio" last="Ricceri">Fulvio Ricceri</name></author><author><name sortKey="Mercurio, Maurizio" sort="Mercurio, Maurizio" uniqKey="Mercurio M" first="Maurizio" last="Mercurio">Maurizio Mercurio</name></author><author><name sortKey="Descombes, Patrick" sort="Descombes, Patrick" uniqKey="Descombes P" first="Patrick" last="Descombes">Patrick Descombes</name></author><author><name sortKey="Marconi, Maurizio" sort="Marconi, Maurizio" uniqKey="Marconi M" first="Maurizio" last="Marconi">Maurizio Marconi</name></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name></author><author><name sortKey="Harrap, Stephen" sort="Harrap, Stephen" uniqKey="Harrap S" first="Stephen" last="Harrap">Stephen Harrap</name></author><author><name sortKey="Filipovsky, Jan" sort="Filipovsky, Jan" uniqKey="Filipovsky J" first="Jan" last="Filipovsky">Jan Filipovsky</name></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name></author><author><name sortKey="Iacoviello, Licia" sort="Iacoviello, Licia" uniqKey="Iacoviello L" first="Licia" last="Iacoviello">Licia Iacoviello</name></author><author><name sortKey="Ellis, Justine" sort="Ellis, Justine" uniqKey="Ellis J" first="Justine" last="Ellis">Justine Ellis</name></author><author><name sortKey="Stanton, Alice V" sort="Stanton, Alice V" uniqKey="Stanton A" first="Alice V." last="Stanton">Alice V. Stanton</name></author><author><name sortKey="Laan, Maris" sort="Laan, Maris" uniqKey="Laan M" first="Maris" last="Laan">Maris Laan</name></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name></author><author><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F." last="Dominiczak">Anna F. Dominiczak</name></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name></author><author><name sortKey="Jeunemaitre, Xavier" sort="Jeunemaitre, Xavier" uniqKey="Jeunemaitre X" first="Xavier" last="Jeunemaitre">Xavier Jeunemaitre</name></author><author><name sortKey="Manunta, Paolo" sort="Manunta, Paolo" uniqKey="Manunta P" first="Paolo" last="Manunta">Paolo Manunta</name></author><author><name sortKey="Shabo, Amnon" sort="Shabo, Amnon" uniqKey="Shabo A" first="Amnon" last="Shabo">Amnon Shabo</name></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name></author><author><name sortKey="Cappuccio, Francesco P" sort="Cappuccio, Francesco P" uniqKey="Cappuccio F" first="Francesco P." last="Cappuccio">Francesco P. Cappuccio</name></author><author><name sortKey="Caulfield, Mark J" sort="Caulfield, Mark J" uniqKey="Caulfield M" first="Mark J." last="Caulfield">Mark J. Caulfield</name></author><author><name sortKey="Matullo, Giuseppe" sort="Matullo, Giuseppe" uniqKey="Matullo G" first="Giuseppe" last="Matullo">Giuseppe Matullo</name></author><author><name sortKey="Rivolta, Carlo" sort="Rivolta, Carlo" uniqKey="Rivolta C" first="Carlo" last="Rivolta">Carlo Rivolta</name></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B." last="Munroe">Patricia B. Munroe</name></author><author><name sortKey="Barlassina, Cristina" sort="Barlassina, Cristina" uniqKey="Barlassina C" first="Cristina" last="Barlassina">Cristina Barlassina</name></author><author><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A" last="Staessen">Jan A. Staessen</name></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name></author><author><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name></author></analytic><series><title level="j">Hypertension</title><idno type="ISSN">0194-911X</idno><idno type="eISSN">1524-4563</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Essential hypertension is a multi-factorial disorder and is the main risk factor for renal and cardiovascular complications. The research on the genetics of hypertension has been frustrated by the small predictive value of the discovered genetic variants. The HYPERGENES Project investigated associations between genetic variants and essential hypertension pursuing a two-stage study by recruiting cases and controls from extensively characterized cohorts recruited over many years in different European regions.</p><p id="P2">The discovery phase consisted of 1,865 cases and 1,750 controls genotyped with 1M Illumina array. Best hits were followed up in a validation panel of 1,385 cases and 1,246 controls that were genotyped with a custom array of 14,055 markers. We identified a new hypertension susceptibility locus (rs3918226) in the promoter region of the endothelial nitric oxide synthase (eNOS) gene (odds ratio 1.54; 95% CI 1.37-1.73; combined p=2.58·10<sup>−13</sup>). A meta-analysis, using other <italic>in-silico</italic>/<italic>de novo</italic> genotyping data for a total of 21714 subjects, resulted in an overall odds ratio of 1.34 (95% CI 1.25-1.44, p=1.032·10<sup>−14</sup>). The quantitative analysis on a population-based sample revealed an effect size of 1.91 (95% CI 0.16-3.66) for systolic and 1.40 (95% CI 0.25-2.55) for diastolic blood pressure. We identified <italic>in-silico</italic> a potential binding site for ETS transcription-factors directly next to <italic>rs3918226,</italic> suggesting a potential modulation of eNOS expression. Biological evidence links eNOS with hypertension, as it is a critical mediator of cardiovascular homeostasis and blood pressure control via vascular tone regulation. This finding supports the hypothesis that there may be a causal genetic variation at this locus.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7906255</journal-id><journal-id journal-id-type="pubmed-jr-id">4217</journal-id><journal-id journal-id-type="nlm-ta">Hypertension</journal-id><journal-id journal-id-type="iso-abbrev">Hypertension</journal-id><journal-title-group><journal-title>Hypertension</journal-title></journal-title-group><issn pub-type="ppub">0194-911X</issn><issn pub-type="epub">1524-4563</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22184326</article-id><article-id pub-id-type="pmc">3272453</article-id><article-id pub-id-type="doi">10.1161/HYPERTENSIONAHA.111.181990</article-id><article-id pub-id-type="manuscript">UKMS40366</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Genome-wide association study using a high-density SNP-array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of <italic>eNOS</italic></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Salvi</surname><given-names>Erika</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kutalik</surname><given-names>Zoltán</given-names></name></contrib><contrib contrib-type="author"><name><surname>Glorioso</surname><given-names>Nicola</given-names></name></contrib><contrib contrib-type="author"><name><surname>Benaglio</surname><given-names>Paola</given-names></name></contrib><contrib contrib-type="author"><name><surname>Frau</surname><given-names>Francesca</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kuznetsova</surname><given-names>Tatiana</given-names></name></contrib><contrib contrib-type="author"><name><surname>Arima</surname><given-names>Hisatomi</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hoggart</surname><given-names>Clive</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tichet</surname><given-names>Jean</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nikitin</surname><given-names>Yury P.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Conti</surname><given-names>Costanza</given-names></name></contrib><contrib contrib-type="author"><name><surname>Seidlerova</surname><given-names>Jitka</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tikhonoff</surname><given-names>Valérie</given-names></name></contrib><contrib contrib-type="author"><name><surname>Stolarz-Skrzypek</surname><given-names>Katarzyna</given-names></name></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Toby</given-names></name></contrib><contrib contrib-type="author"><name><surname>Devos</surname><given-names>Nabila</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zagato</surname><given-names>Laura</given-names></name></contrib><contrib contrib-type="author"><name><surname>Guarrera</surname><given-names>Simonetta</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zaninello</surname><given-names>Roberta</given-names></name></contrib><contrib contrib-type="author"><name><surname>Calabria</surname><given-names>Andrea</given-names></name></contrib><contrib contrib-type="author"><name><surname>Stancanelli</surname><given-names>Benedetta</given-names></name></contrib><contrib contrib-type="author"><name><surname>Troffa</surname><given-names>Chiara</given-names></name></contrib><contrib contrib-type="author"><name><surname>Thijs</surname><given-names>Lutgarde</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rizzi</surname><given-names>Federica</given-names></name></contrib><contrib contrib-type="author"><name><surname>Simonova</surname><given-names>Galina</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lupoli</surname><given-names>Sara</given-names></name></contrib><contrib contrib-type="author"><name><surname>Argiolas</surname><given-names>Giuseppe</given-names></name></contrib><contrib contrib-type="author"><name><surname>Braga</surname><given-names>Daniele</given-names></name></contrib><contrib contrib-type="author"><name><surname>D’Alessio</surname><given-names>Maria C.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ortu</surname><given-names>Maria F.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ricceri</surname><given-names>Fulvio</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mercurio</surname><given-names>Maurizio</given-names></name></contrib><contrib contrib-type="author"><name><surname>Descombes</surname><given-names>Patrick</given-names></name></contrib><contrib contrib-type="author"><name><surname>Marconi</surname><given-names>Maurizio</given-names></name></contrib><contrib contrib-type="author"><name><surname>Chalmers</surname><given-names>John</given-names></name></contrib><contrib contrib-type="author"><name><surname>Harrap</surname><given-names>Stephen</given-names></name></contrib><contrib contrib-type="author"><name><surname>Filipovsky</surname><given-names>Jan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bochud</surname><given-names>Murielle</given-names></name></contrib><contrib contrib-type="author"><name><surname>Iacoviello</surname><given-names>Licia</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ellis</surname><given-names>Justine</given-names></name></contrib><contrib contrib-type="author"><name><surname>Stanton</surname><given-names>Alice V.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Laan</surname><given-names>Maris</given-names></name></contrib><contrib contrib-type="author"><name><surname>Padmanabhan</surname><given-names>Sandosh</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dominiczak</surname><given-names>Anna F.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Samani</surname><given-names>Nilesh J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Melander</surname><given-names>Olle</given-names></name></contrib><contrib contrib-type="author"><name><surname>Jeunemaitre</surname><given-names>Xavier</given-names></name></contrib><contrib contrib-type="author"><name><surname>Manunta</surname><given-names>Paolo</given-names></name></contrib><contrib contrib-type="author"><name><surname>Shabo</surname><given-names>Amnon</given-names></name></contrib><contrib contrib-type="author"><name><surname>Vineis</surname><given-names>Paolo</given-names></name></contrib><contrib contrib-type="author"><name><surname>Cappuccio</surname><given-names>Francesco P.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Caulfield</surname><given-names>Mark J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Matullo</surname><given-names>Giuseppe</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rivolta</surname><given-names>Carlo</given-names></name></contrib><contrib contrib-type="author"><name><surname>Munroe</surname><given-names>Patricia B.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Barlassina</surname><given-names>Cristina</given-names></name></contrib><contrib contrib-type="author"><name><surname>Staessen</surname><given-names>Jan A</given-names></name></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Jacques S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Cusi</surname><given-names>Daniele</given-names></name></contrib><aff id="A1">Dept. of Medicine, Surgery and Dentistry, University of Milano. Graduate School of Nephrology, University of Milano, Division of Nephrology, San Paolo Hospital, Milano, Italy (E.S., F.F., A.C., S.L., C.B., D.C.); Filarete Foundation, Genomic and Bioinformatics Unit, Milano (E.S., F.F, A.C., S.L., C.B., D.C.); Department of Medical Genetics, University of Lausanne, Switzerland (Z.K. , P.B., C.R, J.S.B).; Swiss Institute of Bioinformatics, Lausanne, Switzerland (Z.K.); Hypertension and Related Diseases Centre-AOU, University of Sassari, Italy (N.G., R.Z., C.T., G.A., M.F.O.); Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium (T.K., L.T., J.A.S.); The George Institute for Global Health, University of Sydney and the Royal Prince Alfred Hospital (H.A., J.C.); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom ( C.H., P.V.); IRSA, Institut inter Régional pour la Santé, Tours, France (J.T.); Institute of Internal Medicine, Siberian Branch of the Russian Academy of Medical Sciences – Novosibirsk – Russian Federation (Y.P.N., G.S.); I.M.S., Milano, Italy (C.C., M.C.D.); 2nd Department of Internal Medicine, Charles University, Medical, Faculty, Pilsen, Czech Republic (J.S.); University of Padova, Department of Clinical and Experimental Medicine, Padova, Italy (V.T.); First Department of Cardiology and Hypertension, Jagiellonian University Medical College, Krakow, Poland (K.S-S.); Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK (T.J., M.J.C., P.B.M.); INSERM, UMRS-970, PARCC, Paris France (N.D., X.J.); Chair of Nephrology, Università Vita Salute San Raffaele; Nephrology, Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy (L.Z., P.M.); Human Genetics Foundation (HUGEF), Turin, Italy (S.G., P.V.); Department of Medicine, University of Catania, Italy (B.S.); KOS Genetic, Milano, Italy (F.R., D.G., M.M.); Department of Genetics, Biology and Biochemistry, University of Torino and Human Genetics Foundation (HUGEF) (F.R., G.M.); Genomics Platform, NCCR "Frontiers in Genetics" CMU University of Geneva Switzerland (P.D.); Center of Transfusion Medicine and Immunohematology, Department of Regenerative Medicine, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano (M.M.), Department of Physiology, University of Melbourne, Melbourne (S.H.); 2nd Medical Department, Cardiology and Angiology, 1st Medical Faculty, Charles University, Prague, Czech Republic (J.F.); Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, 1005 Lausanne, Switzerland (M.B.); Research Laboratories “John Paul II” Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy (L.I.); Murdoch Childrens Research Institute, Melbourne, Australia. Department of Physiology, University of Melbourne, Melbourne, Australia (J.E.); Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland (A.V.S.); Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia (M.L.); BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TA, UK (A.F.D., S.P.); BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TA, UK (N.J.S.); Department of Cardiovascular Sciences, University of Leicester, Leicester, UK LE3 9QP (N.J.S.); Hypertension and Cardiovascular Disease, Department of Clinical Sciences, Lund University, Malmö Sweden (O.M.); Centre of Emergency Medicine, Skåne University Hospital, Malmö, Sweden (O.M.); University Paris Descartes, Paris France (X.J.); APHP, Department of Genetics, Hopital Europeen Georges Pompidou, Paris France (X.J.); IBM Haifa Research Lab, Haifa Univ. Mount Carmel Haifa, Israel (A.S.); University of Warwick, Warwick Medical School, Coventry, United Kingdom (F.P.C.); Genetic Epidemiology Unit, Department of Epidemiology, Maastricht University, 6200 MD Maastricht, Netherlands (J.A.S.); Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois(CHUV) University Hospital, Lausanne, Switzerland (J.S.B.)</aff></contrib-group><author-notes><corresp id="CR1">Corresponding Author: Prof. Daniele Cusi MD Coordinator of HYPERGENES Project Dept. of Medicine, Surgery and Dentistry, University of Milano Chairman Division of Nephrology, San Paolo Hospital, Milano Viale Ortles 22/4, 20139 Milano Italy <email>daniele.cusi@unimi.it</email> Tel: +39 /02 56660130 Fax: + 39 / 02 537250</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>1</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>19</day><month>12</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>8</month><year>2012</year></pub-date><volume>59</volume><issue>2</issue><fpage>248</fpage><lpage>255</lpage><abstract><p id="P1">Essential hypertension is a multi-factorial disorder and is the main risk factor for renal and cardiovascular complications. The research on the genetics of hypertension has been frustrated by the small predictive value of the discovered genetic variants. The HYPERGENES Project investigated associations between genetic variants and essential hypertension pursuing a two-stage study by recruiting cases and controls from extensively characterized cohorts recruited over many years in different European regions.</p><p id="P2">The discovery phase consisted of 1,865 cases and 1,750 controls genotyped with 1M Illumina array. Best hits were followed up in a validation panel of 1,385 cases and 1,246 controls that were genotyped with a custom array of 14,055 markers. We identified a new hypertension susceptibility locus (rs3918226) in the promoter region of the endothelial nitric oxide synthase (eNOS) gene (odds ratio 1.54; 95% CI 1.37-1.73; combined p=2.58·10<sup>−13</sup>). A meta-analysis, using other <italic>in-silico</italic>/<italic>de novo</italic> genotyping data for a total of 21714 subjects, resulted in an overall odds ratio of 1.34 (95% CI 1.25-1.44, p=1.032·10<sup>−14</sup>). The quantitative analysis on a population-based sample revealed an effect size of 1.91 (95% CI 0.16-3.66) for systolic and 1.40 (95% CI 0.25-2.55) for diastolic blood pressure. We identified <italic>in-silico</italic> a potential binding site for ETS transcription-factors directly next to <italic>rs3918226,</italic> suggesting a potential modulation of eNOS expression. Biological evidence links eNOS with hypertension, as it is a critical mediator of cardiovascular homeostasis and blood pressure control via vascular tone regulation. This finding supports the hypothesis that there may be a causal genetic variation at this locus.</p></abstract><kwd-group><kwd>genetic epidemiology</kwd><kwd>risk factors</kwd><kwd>genetics-association studies</kwd><kwd>nitric oxide</kwd><kwd>Essential Hypertension</kwd></kwd-group><funding-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>093078 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">British Heart Foundation : </funding-source><award-id>PG/02/128/14470 || BHF_</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Argiolas, Giuseppe" sort="Argiolas, Giuseppe" uniqKey="Argiolas G" first="Giuseppe" last="Argiolas">Giuseppe Argiolas</name><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name><name sortKey="Barlassina, Cristina" sort="Barlassina, Cristina" uniqKey="Barlassina C" first="Cristina" last="Barlassina">Cristina Barlassina</name><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name><name sortKey="Benaglio, Paola" sort="Benaglio, Paola" uniqKey="Benaglio P" first="Paola" last="Benaglio">Paola Benaglio</name><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><name sortKey="Braga, Daniele" sort="Braga, Daniele" uniqKey="Braga D" first="Daniele" last="Braga">Daniele Braga</name><name sortKey="Calabria, Andrea" sort="Calabria, Andrea" uniqKey="Calabria A" first="Andrea" last="Calabria">Andrea Calabria</name><name sortKey="Cappuccio, Francesco P" sort="Cappuccio, Francesco P" uniqKey="Cappuccio F" first="Francesco P." last="Cappuccio">Francesco P. Cappuccio</name><name sortKey="Caulfield, Mark J" sort="Caulfield, Mark J" uniqKey="Caulfield M" first="Mark J." last="Caulfield">Mark J. Caulfield</name><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><name sortKey="Conti, Costanza" sort="Conti, Costanza" uniqKey="Conti C" first="Costanza" last="Conti">Costanza Conti</name><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name><name sortKey="D Lessio, Maria C" sort="D Lessio, Maria C" uniqKey="D Lessio M" first="Maria C." last="D Lessio">Maria C. D Lessio</name><name sortKey="Descombes, Patrick" sort="Descombes, Patrick" uniqKey="Descombes P" first="Patrick" last="Descombes">Patrick Descombes</name><name sortKey="Devos, Nabila" sort="Devos, Nabila" uniqKey="Devos N" first="Nabila" last="Devos">Nabila Devos</name><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F." last="Dominiczak">Anna F. Dominiczak</name><name sortKey="Ellis, Justine" sort="Ellis, Justine" uniqKey="Ellis J" first="Justine" last="Ellis">Justine Ellis</name><name sortKey="Filipovsky, Jan" sort="Filipovsky, Jan" uniqKey="Filipovsky J" first="Jan" last="Filipovsky">Jan Filipovsky</name><name sortKey="Frau, Francesca" sort="Frau, Francesca" uniqKey="Frau F" first="Francesca" last="Frau">Francesca Frau</name><name sortKey="Glorioso, Nicola" sort="Glorioso, Nicola" uniqKey="Glorioso N" first="Nicola" last="Glorioso">Nicola Glorioso</name><name sortKey="Guarrera, Simonetta" sort="Guarrera, Simonetta" uniqKey="Guarrera S" first="Simonetta" last="Guarrera">Simonetta Guarrera</name><name sortKey="Harrap, Stephen" sort="Harrap, Stephen" uniqKey="Harrap S" first="Stephen" last="Harrap">Stephen Harrap</name><name sortKey="Hoggart, Clive" sort="Hoggart, Clive" uniqKey="Hoggart C" first="Clive" last="Hoggart">Clive Hoggart</name><name sortKey="Iacoviello, Licia" sort="Iacoviello, Licia" uniqKey="Iacoviello L" first="Licia" last="Iacoviello">Licia Iacoviello</name><name sortKey="Jeunemaitre, Xavier" sort="Jeunemaitre, Xavier" uniqKey="Jeunemaitre X" first="Xavier" last="Jeunemaitre">Xavier Jeunemaitre</name><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><name sortKey="Kuznetsova, Tatiana" sort="Kuznetsova, Tatiana" uniqKey="Kuznetsova T" first="Tatiana" last="Kuznetsova">Tatiana Kuznetsova</name><name sortKey="Laan, Maris" sort="Laan, Maris" uniqKey="Laan M" first="Maris" last="Laan">Maris Laan</name><name sortKey="Lupoli, Sara" sort="Lupoli, Sara" uniqKey="Lupoli S" first="Sara" last="Lupoli">Sara Lupoli</name><name sortKey="Manunta, Paolo" sort="Manunta, Paolo" uniqKey="Manunta P" first="Paolo" last="Manunta">Paolo Manunta</name><name sortKey="Marconi, Maurizio" sort="Marconi, Maurizio" uniqKey="Marconi M" first="Maurizio" last="Marconi">Maurizio Marconi</name><name sortKey="Matullo, Giuseppe" sort="Matullo, Giuseppe" uniqKey="Matullo G" first="Giuseppe" last="Matullo">Giuseppe Matullo</name><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><name sortKey="Mercurio, Maurizio" sort="Mercurio, Maurizio" uniqKey="Mercurio M" first="Maurizio" last="Mercurio">Maurizio Mercurio</name><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B." last="Munroe">Patricia B. Munroe</name><name sortKey="Nikitin, Yury P" sort="Nikitin, Yury P" uniqKey="Nikitin Y" first="Yury P." last="Nikitin">Yury P. Nikitin</name><name sortKey="Ortu, Maria F" sort="Ortu, Maria F" uniqKey="Ortu M" first="Maria F." last="Ortu">Maria F. Ortu</name><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><name sortKey="Ricceri, Fulvio" sort="Ricceri, Fulvio" uniqKey="Ricceri F" first="Fulvio" last="Ricceri">Fulvio Ricceri</name><name sortKey="Rivolta, Carlo" sort="Rivolta, Carlo" uniqKey="Rivolta C" first="Carlo" last="Rivolta">Carlo Rivolta</name><name sortKey="Rizzi, Federica" sort="Rizzi, Federica" uniqKey="Rizzi F" first="Federica" last="Rizzi">Federica Rizzi</name><name sortKey="Salvi, Erika" sort="Salvi, Erika" uniqKey="Salvi E" first="Erika" last="Salvi">Erika Salvi</name><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><name sortKey="Seidlerova, Jitka" sort="Seidlerova, Jitka" uniqKey="Seidlerova J" first="Jitka" last="Seidlerova">Jitka Seidlerova</name><name sortKey="Shabo, Amnon" sort="Shabo, Amnon" uniqKey="Shabo A" first="Amnon" last="Shabo">Amnon Shabo</name><name sortKey="Simonova, Galina" sort="Simonova, Galina" uniqKey="Simonova G" first="Galina" last="Simonova">Galina Simonova</name><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A" last="Staessen">Jan A. Staessen</name><name sortKey="Stancanelli, Benedetta" sort="Stancanelli, Benedetta" uniqKey="Stancanelli B" first="Benedetta" last="Stancanelli">Benedetta Stancanelli</name><name sortKey="Stanton, Alice V" sort="Stanton, Alice V" uniqKey="Stanton A" first="Alice V." last="Stanton">Alice V. Stanton</name><name sortKey="Stolarz Skrzypek, Katarzyna" sort="Stolarz Skrzypek, Katarzyna" uniqKey="Stolarz Skrzypek K" first="Katarzyna" last="Stolarz-Skrzypek">Katarzyna Stolarz-Skrzypek</name><name sortKey="Thijs, Lutgarde" sort="Thijs, Lutgarde" uniqKey="Thijs L" first="Lutgarde" last="Thijs">Lutgarde Thijs</name><name sortKey="Tichet, Jean" sort="Tichet, Jean" uniqKey="Tichet J" first="Jean" last="Tichet">Jean Tichet</name><name sortKey="Tikhonoff, Valerie" sort="Tikhonoff, Valerie" uniqKey="Tikhonoff V" first="Valérie" last="Tikhonoff">Valérie Tikhonoff</name><name sortKey="Troffa, Chiara" sort="Troffa, Chiara" uniqKey="Troffa C" first="Chiara" last="Troffa">Chiara Troffa</name><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><name sortKey="Zagato, Laura" sort="Zagato, Laura" uniqKey="Zagato L" first="Laura" last="Zagato">Laura Zagato</name><name sortKey="Zaninello, Roberta" sort="Zaninello, Roberta" uniqKey="Zaninello R" first="Roberta" last="Zaninello">Roberta Zaninello</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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