Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus
Identifieur interne : 001B10 ( Pmc/Checkpoint ); précédent : 001B09; suivant : 001B11Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus
Auteurs : Yi Lu [Australie] ; Veronique Vitart [Royaume-Uni] ; Kathryn P. Burdon [Australie] ; Chiea Chuen Khor [Singapour] ; Yelena Bykhovskaya [États-Unis] ; Alireza Mirshahi [Allemagne] ; Alex W. Hewitt [Australie] ; Demelza Koehn [États-Unis] ; Pirro G. Hysi [Royaume-Uni] ; Wishal D. Ramdas [Pays-Bas] ; Tanja Zeller [Allemagne] ; Eranga N. Vithana [Singapour] ; Belinda K. Cornes [Singapour] ; Wan-Ting Tay [Singapour] ; E Shyong Tai [Singapour] ; Ching-Yu Cheng [Singapour] ; Jianjun Liu [Singapour] ; Jia-Nee Foo [Singapour] ; Seang Mei Saw [Singapour] ; Gudmar Thorleifsson [Islande] ; Kari Stefansson [Islande] ; David P. Dimasi [Australie] ; Richard A. Mills [Australie] ; Jenny Mountain [Australie] ; Wei Ang [Australie] ; René Hoehn [Allemagne] ; Virginie J M. Verhoeven [Pays-Bas] ; Franz Grus [Allemagne] ; Roger Wolfs [Pays-Bas] ; Raphaële Castagne [France] ; Karl J. Lackner [Allemagne] ; Henriët Springelkamp [Pays-Bas] ; Jian Yang [Australie] ; Fridbert Jonasson [Islande] ; Dexter Y L. Leung [Hong Kong] ; Li J. Chen [Hong Kong] ; Clement C Y. Tham [Hong Kong] ; Igor Rudan [Royaume-Uni, Croatie] ; Zoran Vatavuk [Croatie] ; Caroline Hayward [Royaume-Uni] ; Jane Gibson [Royaume-Uni] ; Angela J. Cree [Royaume-Uni] ; Alex Macleod [Royaume-Uni] ; Sarah Ennis [Royaume-Uni] ; Ozren Polasek [Croatie] ; Harry Campbell [Royaume-Uni] ; James F. Wilson [Royaume-Uni] ; Ananth C. Viswanathan [Royaume-Uni] ; Brian Fleck [Royaume-Uni] ; Xiaohui Li [États-Unis] ; David Siscovick [États-Unis] ; Kent D. Taylor [États-Unis] ; Jerome I. Rotter [États-Unis] ; Seyhan Yazar [Australie] ; Megan Ulmer [États-Unis] ; Jun Li [États-Unis] ; Brian L. Yaspan [États-Unis] ; Ayse B. Ozel [États-Unis] ; Julia E. Richards [États-Unis] ; Sayoko E. Moroi [États-Unis] ; Jonathan L. Haines [États-Unis] ; Jae H. Kang [États-Unis] ; Louis R. Pasquale [États-Unis] ; R Rand Allingham [États-Unis] ; Allison Ashley-Koch [États-Unis] ; Paul Mitchell [Australie] ; Jie Jin Wang [Australie] ; Alan F. Wright [Royaume-Uni] ; Craig Pennell [Australie] ; Timothy D. Spector [Royaume-Uni] ; Terri L. Young [États-Unis, Singapour] ; Caroline C W. Klaver [Pays-Bas] ; Nicholas G. Martin [Australie] ; Grant W. Montgomery [Australie] ; Michael G. Anderson [États-Unis] ; Tin Aung [Singapour] ; Colin E. Willoughby [Royaume-Uni] ; Janey L. Wiggs [États-Unis] ; Chi P. Pang [Hong Kong] ; Unnur Thorsteinsdottir [Islande] ; Andrew J. Lotery [Royaume-Uni] ; Christopher J. Hammond [Royaume-Uni] ; Cornelia M. Van Duijn [Pays-Bas] ; Michael A. Hauser [États-Unis] ; Yaron S. Rabinowitz [États-Unis] ; Norbert Pfeiffer [Allemagne] ; David A. Mackey [Australie] ; Jamie E. Craig [Australie] ; Stuart Macgregor [Australie] ; Tien Y. Wong [Singapour, États-Unis]Source :
- Nature genetics [ 1061-4036 ] ; 2013.
Abstract
Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma. We performed a meta-analysis on >20,000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide significance (
Url:
DOI: 10.1038/ng.2506
PubMed: 23291589
PubMed Central: 3720123
Affiliations:
- Allemagne, Australie, Croatie, France, Hong Kong, Islande, Pays-Bas, Royaume-Uni, Singapour, États-Unis
- Angleterre, Californie, Caroline du Nord, Grand Londres, Hambourg, Hollande-Méridionale, Iowa, Massachusetts, Michigan, Nouvelle-Galles du Sud, Rhénanie-Palatinat, Tennessee, Victoria (État), Washington (État), Écosse, Île-de-France
- Hambourg, Iowa City, Londres, Mayence, Melbourne, Paris, Rotterdam, Seattle, Sha Tin, Sydney, Édimbourg
- Université chinoise de Hong Kong, Université d'Édimbourg, Université de Melbourne, Université de Sydney, Université de Washington, Université de l'Iowa, Université nationale de Singapour
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<author><name sortKey="Cornes, Belinda K" sort="Cornes, Belinda K" uniqKey="Cornes B" first="Belinda K" last="Cornes">Belinda K. Cornes</name>
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<affiliation wicri:level="4"><nlm:aff id="A17">Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
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<author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name>
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<affiliation wicri:level="4"><nlm:aff id="A5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
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<affiliation wicri:level="4"><nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="A18">Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of SIngapore Graduate Medical School, Singapore</nlm:aff>
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<author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name>
<affiliation wicri:level="4"><nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
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<affiliation wicri:level="1"><nlm:aff id="A7">Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore</nlm:aff>
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<author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia-Nee" last="Foo">Jia-Nee Foo</name>
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<author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang Mei" last="Saw">Seang Mei Saw</name>
<affiliation wicri:level="4"><nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
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<author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name>
<affiliation wicri:level="1"><nlm:aff id="A19">deCODE genetics, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Reykjavik</wicri:regionArea>
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<author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name>
<affiliation wicri:level="1"><nlm:aff id="A19">deCODE genetics, Reykjavik, Iceland</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="A20">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
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<author><name sortKey="Dimasi, David P" sort="Dimasi, David P" uniqKey="Dimasi D" first="David P" last="Dimasi">David P. Dimasi</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia</nlm:aff>
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<author><name sortKey="Mills, Richard A" sort="Mills, Richard A" uniqKey="Mills R" first="Richard A" last="Mills">Richard A. Mills</name>
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<wicri:regionArea>Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia</wicri:regionArea>
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<author><name sortKey="Mountain, Jenny" sort="Mountain, Jenny" uniqKey="Mountain J" first="Jenny" last="Mountain">Jenny Mountain</name>
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<author><name sortKey="Ang, Wei" sort="Ang, Wei" uniqKey="Ang W" first="Wei" last="Ang">Wei Ang</name>
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<author><name sortKey="Hoehn, Rene" sort="Hoehn, Rene" uniqKey="Hoehn R" first="René" last="Hoehn">René Hoehn</name>
<affiliation wicri:level="3"><nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
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<author><name sortKey="Verhoeven, Virginie J M" sort="Verhoeven, Virginie J M" uniqKey="Verhoeven V" first="Virginie J M" last="Verhoeven">Virginie J M. Verhoeven</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
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<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grus, Franz" sort="Grus, Franz" uniqKey="Grus F" first="Franz" last="Grus">Franz Grus</name>
<affiliation wicri:level="3"><nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wolfs, Roger" sort="Wolfs, Roger" uniqKey="Wolfs R" first="Roger" last="Wolfs">Roger Wolfs</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Castagne, Raphaele" sort="Castagne, Raphaele" uniqKey="Castagne R" first="Raphaële" last="Castagne">Raphaële Castagne</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Institut de Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche de Santé (UMRS) 937, Pierre and Marie Curie University and Medical School, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche de Santé (UMRS) 937, Pierre and Marie Curie University and Medical School, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lackner, Karl J" sort="Lackner, Karl J" uniqKey="Lackner K" first="Karl J" last="Lackner">Karl J. Lackner</name>
<affiliation wicri:level="3"><nlm:aff id="A24">Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Springelkamp, Henriet" sort="Springelkamp, Henriet" uniqKey="Springelkamp H" first="Henriët" last="Springelkamp">Henriët Springelkamp</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name>
<affiliation wicri:level="1"><nlm:aff id="A25">University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jonasson, Fridbert" sort="Jonasson, Fridbert" uniqKey="Jonasson F" first="Fridbert" last="Jonasson">Fridbert Jonasson</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A26">Department of Ophthalmology, Landspitali National University Hospital, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Department of Ophthalmology, Landspitali National University Hospital, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leung, Dexter Y L" sort="Leung, Dexter Y L" uniqKey="Leung D" first="Dexter Y L" last="Leung">Dexter Y L. Leung</name>
<affiliation wicri:level="4"><nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Li J" sort="Chen, Li J" uniqKey="Chen L" first="Li J" last="Chen">Li J. Chen</name>
<affiliation wicri:level="4"><nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tham, Clement C Y" sort="Tham, Clement C Y" uniqKey="Tham C" first="Clement C Y" last="Tham">Clement C Y. Tham</name>
<affiliation wicri:level="4"><nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<affiliation wicri:level="4"><nlm:aff id="A28">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A29">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vatavuk, Zoran" sort="Vatavuk, Zoran" uniqKey="Vatavuk Z" first="Zoran" last="Vatavuk">Zoran Vatavuk</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Department of Ophthalmology, Hospital Sestre Milosrdnice, Zagreb, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Ophthalmology, Hospital Sestre Milosrdnice, Zagreb</wicri:regionArea>
<wicri:noRegion>Zagreb</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Gibson, Jane" sort="Gibson, Jane" uniqKey="Gibson J" first="Jane" last="Gibson">Jane Gibson</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cree, Angela J" sort="Cree, Angela J" uniqKey="Cree A" first="Angela J" last="Cree">Angela J. Cree</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Macleod, Alex" sort="Macleod, Alex" uniqKey="Macleod A" first="Alex" last="Macleod">Alex Macleod</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Southampton Eye Unit, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Southampton Eye Unit, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ennis, Sarah" sort="Ennis, Sarah" uniqKey="Ennis S" first="Sarah" last="Ennis">Sarah Ennis</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A34">Department of Public Health, University of Split, Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Public Health, University of Split, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation wicri:level="4"><nlm:aff id="A28">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name>
<affiliation wicri:level="4"><nlm:aff id="A28">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Viswanathan, Ananth C" sort="Viswanathan, Ananth C" uniqKey="Viswanathan A" first="Ananth C" last="Viswanathan">Ananth C. Viswanathan</name>
<affiliation wicri:level="3"><nlm:aff id="A35">National Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fleck, Brian" sort="Fleck, Brian" uniqKey="Fleck B" first="Brian" last="Fleck">Brian Fleck</name>
<affiliation wicri:level="3"><nlm:aff id="A36">Princess Alexandra Eye Pavilion, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Princess Alexandra Eye Pavilion, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Xiaohui" sort="Li, Xiaohui" uniqKey="Li X" first="Xiaohui" last="Li">Xiaohui Li</name>
<affiliation wicri:level="2"><nlm:aff id="A37">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Siscovick, David" sort="Siscovick, David" uniqKey="Siscovick D" first="David" last="Siscovick">David Siscovick</name>
<affiliation wicri:level="4"><nlm:aff id="A38">Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D" last="Taylor">Kent D. Taylor</name>
<affiliation wicri:level="2"><nlm:aff id="A37">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name>
<affiliation wicri:level="2"><nlm:aff id="A37">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yazar, Seyhan" sort="Yazar, Seyhan" uniqKey="Yazar S" first="Seyhan" last="Yazar">Seyhan Yazar</name>
<affiliation wicri:level="1"><nlm:aff id="A11">Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ulmer, Megan" sort="Ulmer, Megan" uniqKey="Ulmer M" first="Megan" last="Ulmer">Megan Ulmer</name>
<affiliation wicri:level="2"><nlm:aff id="A39">Department of Medicine, Duke University, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Duke University, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name>
<affiliation wicri:level="2"><nlm:aff id="A40">Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yaspan, Brian L" sort="Yaspan, Brian L" uniqKey="Yaspan B" first="Brian L" last="Yaspan">Brian L. Yaspan</name>
<affiliation wicri:level="2"><nlm:aff id="A41">Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ozel, Ayse B" sort="Ozel, Ayse B" uniqKey="Ozel A" first="Ayse B" last="Ozel">Ayse B. Ozel</name>
<affiliation wicri:level="2"><nlm:aff id="A40">Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E" last="Richards">Julia E. Richards</name>
<affiliation wicri:level="2"><nlm:aff id="A42">Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E" last="Moroi">Sayoko E. Moroi</name>
<affiliation wicri:level="2"><nlm:aff id="A42">Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name>
<affiliation wicri:level="2"><nlm:aff id="A41">Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H" last="Kang">Jae H. Kang</name>
<affiliation wicri:level="2"><nlm:aff id="A43">Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R" last="Pasquale">Louis R. Pasquale</name>
<affiliation wicri:level="2"><nlm:aff id="A43">Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A44">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name>
<affiliation wicri:level="2"><nlm:aff id="A45">Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ashley Koch, Allison" sort="Ashley Koch, Allison" uniqKey="Ashley Koch A" first="Allison" last="Ashley-Koch">Allison Ashley-Koch</name>
<affiliation wicri:level="2"><nlm:aff id="A39">Department of Medicine, Duke University, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Duke University, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name>
<affiliation wicri:level="4"><nlm:aff id="A46">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name>
<affiliation wicri:level="4"><nlm:aff id="A46">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Pennell, Craig" sort="Pennell, Craig" uniqKey="Pennell C" first="Craig" last="Pennell">Craig Pennell</name>
<affiliation wicri:level="1"><nlm:aff id="A22">School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name>
<affiliation wicri:level="3"><nlm:aff id="A13">Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Young, Terri L" sort="Young, Terri L" uniqKey="Young T" first="Terri L" last="Young">Terri L. Young</name>
<affiliation wicri:level="2"><nlm:aff id="A47">Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Human Genetics, Duke University Medical Center, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A48">Duke-National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Duke-National University of Singapore</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klaver, Caroline C W" sort="Klaver, Caroline C W" uniqKey="Klaver C" first="Caroline C W" last="Klaver">Caroline C W. Klaver</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><nlm:aff id="A49">Queensland Institute of Medical Research, Genetic Epidemiology, Herston, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Herston, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name>
<affiliation wicri:level="1"><nlm:aff id="A50">Queensland Institute of Medical Research, Molecular Epidemiology, Herston, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research, Molecular Epidemiology, Herston, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Anderson, Michael G" sort="Anderson, Michael G" uniqKey="Anderson M" first="Michael G" last="Anderson">Michael G. Anderson</name>
<affiliation wicri:level="4"><nlm:aff id="A12">Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A51">Department of Ophthamology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthamology and Visual Sciences, University of Iowa, Iowa City, Iowa</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A52">Singapore National Eye Centre, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore National Eye Centre</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Willoughby, Colin E" sort="Willoughby, Colin E" uniqKey="Willoughby C" first="Colin E" last="Willoughby">Colin E. Willoughby</name>
<affiliation wicri:level="1"><nlm:aff id="A53">Centre for Vision and Vascular Science, Queen’s University Belfast, Belfast, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Vision and Vascular Science, Queen’s University Belfast, Belfast</wicri:regionArea>
<wicri:noRegion>Belfast</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L" last="Wiggs">Janey L. Wiggs</name>
<affiliation wicri:level="2"><nlm:aff id="A44">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pang, Chi P" sort="Pang, Chi P" uniqKey="Pang C" first="Chi P" last="Pang">Chi P. Pang</name>
<affiliation wicri:level="4"><nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name>
<affiliation wicri:level="1"><nlm:aff id="A19">deCODE genetics, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A20">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lotery, Andrew J" sort="Lotery, Andrew J" uniqKey="Lotery A" first="Andrew J" last="Lotery">Andrew J. Lotery</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A33">Southampton Eye Unit, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Southampton Eye Unit, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J" last="Hammond">Christopher J. Hammond</name>
<affiliation wicri:level="3"><nlm:aff id="A13">Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name>
<affiliation wicri:level="2"><nlm:aff id="A39">Department of Medicine, Duke University, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Duke University, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rabinowitz, Yaron S" sort="Rabinowitz, Yaron S" uniqKey="Rabinowitz Y" first="Yaron S" last="Rabinowitz">Yaron S. Rabinowitz</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Research, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Research, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A54">Cornea Genetic Eye Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cornea Genetic Eye Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pfeiffer, Norbert" sort="Pfeiffer, Norbert" uniqKey="Pfeiffer N" first="Norbert" last="Pfeiffer">Norbert Pfeiffer</name>
<affiliation wicri:level="3"><nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name>
<affiliation wicri:level="4"><nlm:aff id="A10">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A11">Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia</wicri:regionArea>
<wicri:noRegion>South Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wong, Tien Y" sort="Wong, Tien Y" uniqKey="Wong T" first="Tien Y" last="Wong">Tien Y. Wong</name>
<affiliation wicri:level="4"><nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A45">Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
</titleStmt>
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<idno type="pmid">23291589</idno>
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<idno type="doi">10.1038/ng.2506</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus</title>
<author><name sortKey="Lu, Yi" sort="Lu, Yi" uniqKey="Lu Y" first="Yi" last="Lu">Yi Lu</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P" last="Burdon">Kathryn P. Burdon</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia</wicri:regionArea>
<wicri:noRegion>South Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea Chuen" last="Khor">Chiea Chuen Khor</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A7">Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)</wicri:regionArea>
<wicri:noRegion>Technology and Research (A*STAR)</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bykhovskaya, Yelena" sort="Bykhovskaya, Yelena" uniqKey="Bykhovskaya Y" first="Yelena" last="Bykhovskaya">Yelena Bykhovskaya</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Research, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Research, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mirshahi, Alireza" sort="Mirshahi, Alireza" uniqKey="Mirshahi A" first="Alireza" last="Mirshahi">Alireza Mirshahi</name>
<affiliation wicri:level="3"><nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name>
<affiliation wicri:level="4"><nlm:aff id="A10">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A11">Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koehn, Demelza" sort="Koehn, Demelza" uniqKey="Koehn D" first="Demelza" last="Koehn">Demelza Koehn</name>
<affiliation wicri:level="4"><nlm:aff id="A12">Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G" last="Hysi">Pirro G. Hysi</name>
<affiliation wicri:level="3"><nlm:aff id="A13">Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ramdas, Wishal D" sort="Ramdas, Wishal D" uniqKey="Ramdas W" first="Wishal D" last="Ramdas">Wishal D. Ramdas</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name>
<affiliation wicri:level="3"><nlm:aff id="A16">University Heart Center Hamburg, Clinic for General and Interventional Cardiology, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Heart Center Hamburg, Clinic for General and Interventional Cardiology, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N" last="Vithana">Eranga N. Vithana</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author><name sortKey="Cornes, Belinda K" sort="Cornes, Belinda K" uniqKey="Cornes B" first="Belinda K" last="Cornes">Belinda K. Cornes</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tay, Wan Ting" sort="Tay, Wan Ting" uniqKey="Tay W" first="Wan-Ting" last="Tay">Wan-Ting Tay</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E Shyong" last="Tai">E Shyong Tai</name>
<affiliation wicri:level="4"><nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A17">Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A18">Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of SIngapore Graduate Medical School, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of SIngapore Graduate Medical School</wicri:regionArea>
<wicri:noRegion>Duke-National University of SIngapore Graduate Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name>
<affiliation wicri:level="4"><nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A7">Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)</wicri:regionArea>
<wicri:noRegion>Technology and Research (A*STAR)</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia-Nee" last="Foo">Jia-Nee Foo</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)</wicri:regionArea>
<wicri:noRegion>Technology and Research (A*STAR)</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang Mei" last="Saw">Seang Mei Saw</name>
<affiliation wicri:level="4"><nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name>
<affiliation wicri:level="1"><nlm:aff id="A19">deCODE genetics, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name>
<affiliation wicri:level="1"><nlm:aff id="A19">deCODE genetics, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A20">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dimasi, David P" sort="Dimasi, David P" uniqKey="Dimasi D" first="David P" last="Dimasi">David P. Dimasi</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia</wicri:regionArea>
<wicri:noRegion>South Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mills, Richard A" sort="Mills, Richard A" uniqKey="Mills R" first="Richard A" last="Mills">Richard A. Mills</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia</wicri:regionArea>
<wicri:noRegion>South Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mountain, Jenny" sort="Mountain, Jenny" uniqKey="Mountain J" first="Jenny" last="Mountain">Jenny Mountain</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ang, Wei" sort="Ang, Wei" uniqKey="Ang W" first="Wei" last="Ang">Wei Ang</name>
<affiliation wicri:level="1"><nlm:aff id="A22">School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hoehn, Rene" sort="Hoehn, Rene" uniqKey="Hoehn R" first="René" last="Hoehn">René Hoehn</name>
<affiliation wicri:level="3"><nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Verhoeven, Virginie J M" sort="Verhoeven, Virginie J M" uniqKey="Verhoeven V" first="Virginie J M" last="Verhoeven">Virginie J M. Verhoeven</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grus, Franz" sort="Grus, Franz" uniqKey="Grus F" first="Franz" last="Grus">Franz Grus</name>
<affiliation wicri:level="3"><nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wolfs, Roger" sort="Wolfs, Roger" uniqKey="Wolfs R" first="Roger" last="Wolfs">Roger Wolfs</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Castagne, Raphaele" sort="Castagne, Raphaele" uniqKey="Castagne R" first="Raphaële" last="Castagne">Raphaële Castagne</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Institut de Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche de Santé (UMRS) 937, Pierre and Marie Curie University and Medical School, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche de Santé (UMRS) 937, Pierre and Marie Curie University and Medical School, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lackner, Karl J" sort="Lackner, Karl J" uniqKey="Lackner K" first="Karl J" last="Lackner">Karl J. Lackner</name>
<affiliation wicri:level="3"><nlm:aff id="A24">Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Springelkamp, Henriet" sort="Springelkamp, Henriet" uniqKey="Springelkamp H" first="Henriët" last="Springelkamp">Henriët Springelkamp</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name>
<affiliation wicri:level="1"><nlm:aff id="A25">University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jonasson, Fridbert" sort="Jonasson, Fridbert" uniqKey="Jonasson F" first="Fridbert" last="Jonasson">Fridbert Jonasson</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A26">Department of Ophthalmology, Landspitali National University Hospital, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Department of Ophthalmology, Landspitali National University Hospital, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leung, Dexter Y L" sort="Leung, Dexter Y L" uniqKey="Leung D" first="Dexter Y L" last="Leung">Dexter Y L. Leung</name>
<affiliation wicri:level="4"><nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Li J" sort="Chen, Li J" uniqKey="Chen L" first="Li J" last="Chen">Li J. Chen</name>
<affiliation wicri:level="4"><nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tham, Clement C Y" sort="Tham, Clement C Y" uniqKey="Tham C" first="Clement C Y" last="Tham">Clement C Y. Tham</name>
<affiliation wicri:level="4"><nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<affiliation wicri:level="4"><nlm:aff id="A28">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A29">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vatavuk, Zoran" sort="Vatavuk, Zoran" uniqKey="Vatavuk Z" first="Zoran" last="Vatavuk">Zoran Vatavuk</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Department of Ophthalmology, Hospital Sestre Milosrdnice, Zagreb, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Ophthalmology, Hospital Sestre Milosrdnice, Zagreb</wicri:regionArea>
<wicri:noRegion>Zagreb</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Gibson, Jane" sort="Gibson, Jane" uniqKey="Gibson J" first="Jane" last="Gibson">Jane Gibson</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cree, Angela J" sort="Cree, Angela J" uniqKey="Cree A" first="Angela J" last="Cree">Angela J. Cree</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Macleod, Alex" sort="Macleod, Alex" uniqKey="Macleod A" first="Alex" last="Macleod">Alex Macleod</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Southampton Eye Unit, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Southampton Eye Unit, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ennis, Sarah" sort="Ennis, Sarah" uniqKey="Ennis S" first="Sarah" last="Ennis">Sarah Ennis</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A34">Department of Public Health, University of Split, Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Public Health, University of Split, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation wicri:level="4"><nlm:aff id="A28">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name>
<affiliation wicri:level="4"><nlm:aff id="A28">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Viswanathan, Ananth C" sort="Viswanathan, Ananth C" uniqKey="Viswanathan A" first="Ananth C" last="Viswanathan">Ananth C. Viswanathan</name>
<affiliation wicri:level="3"><nlm:aff id="A35">National Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fleck, Brian" sort="Fleck, Brian" uniqKey="Fleck B" first="Brian" last="Fleck">Brian Fleck</name>
<affiliation wicri:level="3"><nlm:aff id="A36">Princess Alexandra Eye Pavilion, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Princess Alexandra Eye Pavilion, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Xiaohui" sort="Li, Xiaohui" uniqKey="Li X" first="Xiaohui" last="Li">Xiaohui Li</name>
<affiliation wicri:level="2"><nlm:aff id="A37">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Siscovick, David" sort="Siscovick, David" uniqKey="Siscovick D" first="David" last="Siscovick">David Siscovick</name>
<affiliation wicri:level="4"><nlm:aff id="A38">Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D" last="Taylor">Kent D. Taylor</name>
<affiliation wicri:level="2"><nlm:aff id="A37">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name>
<affiliation wicri:level="2"><nlm:aff id="A37">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yazar, Seyhan" sort="Yazar, Seyhan" uniqKey="Yazar S" first="Seyhan" last="Yazar">Seyhan Yazar</name>
<affiliation wicri:level="1"><nlm:aff id="A11">Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ulmer, Megan" sort="Ulmer, Megan" uniqKey="Ulmer M" first="Megan" last="Ulmer">Megan Ulmer</name>
<affiliation wicri:level="2"><nlm:aff id="A39">Department of Medicine, Duke University, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Duke University, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name>
<affiliation wicri:level="2"><nlm:aff id="A40">Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yaspan, Brian L" sort="Yaspan, Brian L" uniqKey="Yaspan B" first="Brian L" last="Yaspan">Brian L. Yaspan</name>
<affiliation wicri:level="2"><nlm:aff id="A41">Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ozel, Ayse B" sort="Ozel, Ayse B" uniqKey="Ozel A" first="Ayse B" last="Ozel">Ayse B. Ozel</name>
<affiliation wicri:level="2"><nlm:aff id="A40">Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E" last="Richards">Julia E. Richards</name>
<affiliation wicri:level="2"><nlm:aff id="A42">Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E" last="Moroi">Sayoko E. Moroi</name>
<affiliation wicri:level="2"><nlm:aff id="A42">Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name>
<affiliation wicri:level="2"><nlm:aff id="A41">Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H" last="Kang">Jae H. Kang</name>
<affiliation wicri:level="2"><nlm:aff id="A43">Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R" last="Pasquale">Louis R. Pasquale</name>
<affiliation wicri:level="2"><nlm:aff id="A43">Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A44">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name>
<affiliation wicri:level="2"><nlm:aff id="A45">Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ashley Koch, Allison" sort="Ashley Koch, Allison" uniqKey="Ashley Koch A" first="Allison" last="Ashley-Koch">Allison Ashley-Koch</name>
<affiliation wicri:level="2"><nlm:aff id="A39">Department of Medicine, Duke University, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Duke University, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name>
<affiliation wicri:level="4"><nlm:aff id="A46">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name>
<affiliation wicri:level="4"><nlm:aff id="A46">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Pennell, Craig" sort="Pennell, Craig" uniqKey="Pennell C" first="Craig" last="Pennell">Craig Pennell</name>
<affiliation wicri:level="1"><nlm:aff id="A22">School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name>
<affiliation wicri:level="3"><nlm:aff id="A13">Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Young, Terri L" sort="Young, Terri L" uniqKey="Young T" first="Terri L" last="Young">Terri L. Young</name>
<affiliation wicri:level="2"><nlm:aff id="A47">Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Human Genetics, Duke University Medical Center, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A48">Duke-National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Duke-National University of Singapore</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klaver, Caroline C W" sort="Klaver, Caroline C W" uniqKey="Klaver C" first="Caroline C W" last="Klaver">Caroline C W. Klaver</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><nlm:aff id="A49">Queensland Institute of Medical Research, Genetic Epidemiology, Herston, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Herston, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name>
<affiliation wicri:level="1"><nlm:aff id="A50">Queensland Institute of Medical Research, Molecular Epidemiology, Herston, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research, Molecular Epidemiology, Herston, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Anderson, Michael G" sort="Anderson, Michael G" uniqKey="Anderson M" first="Michael G" last="Anderson">Michael G. Anderson</name>
<affiliation wicri:level="4"><nlm:aff id="A12">Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A51">Department of Ophthamology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthamology and Visual Sciences, University of Iowa, Iowa City, Iowa</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A52">Singapore National Eye Centre, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore National Eye Centre</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Willoughby, Colin E" sort="Willoughby, Colin E" uniqKey="Willoughby C" first="Colin E" last="Willoughby">Colin E. Willoughby</name>
<affiliation wicri:level="1"><nlm:aff id="A53">Centre for Vision and Vascular Science, Queen’s University Belfast, Belfast, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Vision and Vascular Science, Queen’s University Belfast, Belfast</wicri:regionArea>
<wicri:noRegion>Belfast</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L" last="Wiggs">Janey L. Wiggs</name>
<affiliation wicri:level="2"><nlm:aff id="A44">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pang, Chi P" sort="Pang, Chi P" uniqKey="Pang C" first="Chi P" last="Pang">Chi P. Pang</name>
<affiliation wicri:level="4"><nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name>
<affiliation wicri:level="1"><nlm:aff id="A19">deCODE genetics, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A20">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lotery, Andrew J" sort="Lotery, Andrew J" uniqKey="Lotery A" first="Andrew J" last="Lotery">Andrew J. Lotery</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A33">Southampton Eye Unit, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Southampton Eye Unit, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J" last="Hammond">Christopher J. Hammond</name>
<affiliation wicri:level="3"><nlm:aff id="A13">Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name>
<affiliation wicri:level="2"><nlm:aff id="A39">Department of Medicine, Duke University, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Duke University, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rabinowitz, Yaron S" sort="Rabinowitz, Yaron S" uniqKey="Rabinowitz Y" first="Yaron S" last="Rabinowitz">Yaron S. Rabinowitz</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Research, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Research, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A54">Cornea Genetic Eye Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cornea Genetic Eye Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pfeiffer, Norbert" sort="Pfeiffer, Norbert" uniqKey="Pfeiffer N" first="Norbert" last="Pfeiffer">Norbert Pfeiffer</name>
<affiliation wicri:level="3"><nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name>
<affiliation wicri:level="4"><nlm:aff id="A10">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A11">Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia</wicri:regionArea>
<wicri:noRegion>South Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wong, Tien Y" sort="Wong, Tien Y" uniqKey="Wong T" first="Tien Y" last="Wong">Tien Y. Wong</name>
<affiliation wicri:level="4"><nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A45">Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature genetics</title>
<idno type="ISSN">1061-4036</idno>
<idno type="eISSN">1546-1718</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma. We performed a meta-analysis on >20,000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide significance (<italic>P</italic>
< 5 × 10<sup>−8</sup>
). We further showed that 2 CCT-associated loci, <italic>FOXO1</italic>
and <italic>FNDC3B</italic>
, conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls (rs2721051 near <italic>FOXO1</italic>
had odds ratio (OR) = 1.62, 95% confidence interval (CI) = 1.4–1.88, <italic>P</italic>
= 2.7 × 10<sup>−10</sup>
, and rs4894535 in <italic>FNDC3B</italic>
had OR = 1.47, 95% CI = 1.29–1.68, <italic>P</italic>
= 4.9 × 10<sup>−9</sup>
). <italic>FNDC3B</italic>
was also associated with primary open-angle glaucoma (<italic>P</italic>
= 5.6 × 10<sup>−4</sup>
; tested in 3 cohorts with 2,979 cases and 7,399 controls). Further analyses implicate the collagen and extracellular matrix pathways in the regulation of CCT.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2419</journal-id>
<journal-id journal-id-type="nlm-ta">Nat Genet</journal-id>
<journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id>
<journal-title-group><journal-title>Nature genetics</journal-title>
</journal-title-group>
<issn pub-type="ppub">1061-4036</issn>
<issn pub-type="epub">1546-1718</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23291589</article-id>
<article-id pub-id-type="pmc">3720123</article-id>
<article-id pub-id-type="doi">10.1038/ng.2506</article-id>
<article-id pub-id-type="manuscript">NIHMS479022</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lu</surname>
<given-names>Yi</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN3" ref-type="author-notes">56</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vitart</surname>
<given-names>Veronique</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref rid="FN3" ref-type="author-notes">56</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Burdon</surname>
<given-names>Kathryn P</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
<xref rid="FN3" ref-type="author-notes">56</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Khor</surname>
<given-names>Chiea Chuen</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A7">7</xref>
<xref rid="FN3" ref-type="author-notes">56</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bykhovskaya</surname>
<given-names>Yelena</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mirshahi</surname>
<given-names>Alireza</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hewitt</surname>
<given-names>Alex W</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koehn</surname>
<given-names>Demelza</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hysi</surname>
<given-names>Pirro G</given-names>
</name>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ramdas</surname>
<given-names>Wishal D</given-names>
</name>
<xref ref-type="aff" rid="A14">14</xref>
<xref ref-type="aff" rid="A15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zeller</surname>
<given-names>Tanja</given-names>
</name>
<xref ref-type="aff" rid="A16">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vithana</surname>
<given-names>Eranga N</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cornes</surname>
<given-names>Belinda K</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tay</surname>
<given-names>Wan-Ting</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tai</surname>
<given-names>E Shyong</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cheng</surname>
<given-names>Ching-Yu</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Jianjun</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Foo</surname>
<given-names>Jia-Nee</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Saw</surname>
<given-names>Seang Mei</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thorleifsson</surname>
<given-names>Gudmar</given-names>
</name>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stefansson</surname>
<given-names>Kari</given-names>
</name>
<xref ref-type="aff" rid="A19">19</xref>
<xref ref-type="aff" rid="A20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dimasi</surname>
<given-names>David P</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mills</surname>
<given-names>Richard A</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mountain</surname>
<given-names>Jenny</given-names>
</name>
<xref ref-type="aff" rid="A21">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ang</surname>
<given-names>Wei</given-names>
</name>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hoehn</surname>
<given-names>René</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Verhoeven</surname>
<given-names>Virginie J M</given-names>
</name>
<xref ref-type="aff" rid="A14">14</xref>
<xref ref-type="aff" rid="A15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grus</surname>
<given-names>Franz</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wolfs</surname>
<given-names>Roger</given-names>
</name>
<xref ref-type="aff" rid="A14">14</xref>
<xref ref-type="aff" rid="A15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Castagne</surname>
<given-names>Raphaële</given-names>
</name>
<xref ref-type="aff" rid="A23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lackner</surname>
<given-names>Karl J</given-names>
</name>
<xref ref-type="aff" rid="A24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Springelkamp</surname>
<given-names>Henriët</given-names>
</name>
<xref ref-type="aff" rid="A14">14</xref>
<xref ref-type="aff" rid="A15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Jian</given-names>
</name>
<xref ref-type="aff" rid="A25">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jonasson</surname>
<given-names>Fridbert</given-names>
</name>
<xref ref-type="aff" rid="A20">20</xref>
<xref ref-type="aff" rid="A26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leung</surname>
<given-names>Dexter Y L</given-names>
</name>
<xref ref-type="aff" rid="A27">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Li J</given-names>
</name>
<xref ref-type="aff" rid="A27">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tham</surname>
<given-names>Clement C Y</given-names>
</name>
<xref ref-type="aff" rid="A27">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rudan</surname>
<given-names>Igor</given-names>
</name>
<xref ref-type="aff" rid="A28">28</xref>
<xref ref-type="aff" rid="A29">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vatavuk</surname>
<given-names>Zoran</given-names>
</name>
<xref ref-type="aff" rid="A30">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hayward</surname>
<given-names>Caroline</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gibson</surname>
<given-names>Jane</given-names>
</name>
<xref ref-type="aff" rid="A31">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cree</surname>
<given-names>Angela J</given-names>
</name>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>MacLeod</surname>
<given-names>Alex</given-names>
</name>
<xref ref-type="aff" rid="A33">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ennis</surname>
<given-names>Sarah</given-names>
</name>
<xref ref-type="aff" rid="A31">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Polasek</surname>
<given-names>Ozren</given-names>
</name>
<xref ref-type="aff" rid="A29">29</xref>
<xref ref-type="aff" rid="A34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Campbell</surname>
<given-names>Harry</given-names>
</name>
<xref ref-type="aff" rid="A28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wilson</surname>
<given-names>James F</given-names>
</name>
<xref ref-type="aff" rid="A28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Viswanathan</surname>
<given-names>Ananth C</given-names>
</name>
<xref ref-type="aff" rid="A35">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fleck</surname>
<given-names>Brian</given-names>
</name>
<xref ref-type="aff" rid="A36">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Xiaohui</given-names>
</name>
<xref ref-type="aff" rid="A37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Siscovick</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="A38">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Taylor</surname>
<given-names>Kent D</given-names>
</name>
<xref ref-type="aff" rid="A37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rotter</surname>
<given-names>Jerome I</given-names>
</name>
<xref ref-type="aff" rid="A37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yazar</surname>
<given-names>Seyhan</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ulmer</surname>
<given-names>Megan</given-names>
</name>
<xref ref-type="aff" rid="A39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Jun</given-names>
</name>
<xref ref-type="aff" rid="A40">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yaspan</surname>
<given-names>Brian L</given-names>
</name>
<xref ref-type="aff" rid="A41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ozel</surname>
<given-names>Ayse B</given-names>
</name>
<xref ref-type="aff" rid="A40">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Richards</surname>
<given-names>Julia E</given-names>
</name>
<xref ref-type="aff" rid="A42">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Moroi</surname>
<given-names>Sayoko E</given-names>
</name>
<xref ref-type="aff" rid="A42">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haines</surname>
<given-names>Jonathan L</given-names>
</name>
<xref ref-type="aff" rid="A41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kang</surname>
<given-names>Jae H</given-names>
</name>
<xref ref-type="aff" rid="A43">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pasquale</surname>
<given-names>Louis R</given-names>
</name>
<xref ref-type="aff" rid="A43">43</xref>
<xref ref-type="aff" rid="A44">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Allingham</surname>
<given-names>R Rand</given-names>
</name>
<xref ref-type="aff" rid="A45">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ashley-Koch</surname>
<given-names>Allison</given-names>
</name>
<xref ref-type="aff" rid="A39">39</xref>
</contrib>
<contrib contrib-type="author"><collab>NEIGHBOR Consortium</collab>
<xref rid="FN2" ref-type="author-notes">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mitchell</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="A46">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Jie Jin</given-names>
</name>
<xref ref-type="aff" rid="A46">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wright</surname>
<given-names>Alan F</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pennell</surname>
<given-names>Craig</given-names>
</name>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spector</surname>
<given-names>Timothy D</given-names>
</name>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Young</surname>
<given-names>Terri L</given-names>
</name>
<xref ref-type="aff" rid="A47">48</xref>
<xref ref-type="aff" rid="A48">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Klaver</surname>
<given-names>Caroline C W</given-names>
</name>
<xref ref-type="aff" rid="A14">14</xref>
<xref ref-type="aff" rid="A15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Martin</surname>
<given-names>Nicholas G</given-names>
</name>
<xref ref-type="aff" rid="A49">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Montgomery</surname>
<given-names>Grant W</given-names>
</name>
<xref ref-type="aff" rid="A50">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Anderson</surname>
<given-names>Michael G</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
<xref ref-type="aff" rid="A51">52</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aung</surname>
<given-names>Tin</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="aff" rid="A52">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Willoughby</surname>
<given-names>Colin E</given-names>
</name>
<xref ref-type="aff" rid="A53">54</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wiggs</surname>
<given-names>Janey L</given-names>
</name>
<xref ref-type="aff" rid="A44">44</xref>
<xref rid="FN4" ref-type="author-notes">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pang</surname>
<given-names>Chi P</given-names>
</name>
<xref ref-type="aff" rid="A27">27</xref>
<xref rid="FN4" ref-type="author-notes">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thorsteinsdottir</surname>
<given-names>Unnur</given-names>
</name>
<xref ref-type="aff" rid="A19">19</xref>
<xref ref-type="aff" rid="A20">20</xref>
<xref rid="FN4" ref-type="author-notes">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lotery</surname>
<given-names>Andrew J</given-names>
</name>
<xref ref-type="aff" rid="A32">32</xref>
<xref ref-type="aff" rid="A33">33</xref>
<xref rid="FN3" ref-type="author-notes">56</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hammond</surname>
<given-names>Christopher J</given-names>
</name>
<xref ref-type="aff" rid="A13">13</xref>
<xref rid="FN4" ref-type="author-notes">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Duijn</surname>
<given-names>Cornelia M</given-names>
</name>
<xref ref-type="aff" rid="A15">15</xref>
<xref rid="FN4" ref-type="author-notes">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hauser</surname>
<given-names>Michael A</given-names>
</name>
<xref ref-type="aff" rid="A39">39</xref>
<xref rid="FN4" ref-type="author-notes">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rabinowitz</surname>
<given-names>Yaron S</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A54">55</xref>
<xref rid="FN4" ref-type="author-notes">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pfeiffer</surname>
<given-names>Norbert</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
<xref rid="FN4" ref-type="author-notes">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mackey</surname>
<given-names>David A</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
<xref ref-type="aff" rid="A11">11</xref>
<xref rid="FN4" ref-type="author-notes">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Craig</surname>
<given-names>Jamie E</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
<xref rid="FN4" ref-type="author-notes">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Macgregor</surname>
<given-names>Stuart</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN4" ref-type="author-notes">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wong</surname>
<given-names>Tien Y</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A45">45</xref>
<xref rid="FN4" ref-type="author-notes">57</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland, Australia</aff>
<aff id="A2"><label>2</label>
Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</aff>
<aff id="A3"><label>3</label>
Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia</aff>
<aff id="A4"><label>4</label>
Singapore Eye Research Institute, Singapore</aff>
<aff id="A5"><label>5</label>
Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</aff>
<aff id="A6"><label>6</label>
Saw Swee Hock School of Public Health, National University of Singapore, Singapore</aff>
<aff id="A7"><label>7</label>
Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore</aff>
<aff id="A8"><label>8</label>
Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Research, Los Angeles, California, USA</aff>
<aff id="A9"><label>9</label>
Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</aff>
<aff id="A10"><label>10</label>
Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</aff>
<aff id="A11"><label>11</label>
Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia</aff>
<aff id="A12"><label>12</label>
Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, USA</aff>
<aff id="A13"><label>13</label>
Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London, UK</aff>
<aff id="A14"><label>14</label>
Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</aff>
<aff id="A15"><label>15</label>
Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</aff>
<aff id="A16"><label>16</label>
University Heart Center Hamburg, Clinic for General and Interventional Cardiology, Hamburg, Germany</aff>
<aff id="A17"><label>17</label>
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</aff>
<aff id="A18"><label>18</label>
Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of SIngapore Graduate Medical School, Singapore</aff>
<aff id="A19"><label>19</label>
deCODE genetics, Reykjavik, Iceland</aff>
<aff id="A20"><label>20</label>
Faculty of Medicine, University of Iceland, Reykjavik, Iceland</aff>
<aff id="A21"><label>21</label>
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia</aff>
<aff id="A22"><label>22</label>
School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia, Australia</aff>
<aff id="A23"><label>23</label>
Institut de Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche de Santé (UMRS) 937, Pierre and Marie Curie University and Medical School, Paris, France</aff>
<aff id="A24"><label>24</label>
Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany</aff>
<aff id="A25"><label>25</label>
University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia</aff>
<aff id="A26"><label>26</label>
Department of Ophthalmology, Landspitali National University Hospital, Reykjavik, Iceland</aff>
<aff id="A27"><label>27</label>
Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</aff>
<aff id="A28"><label>28</label>
Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</aff>
<aff id="A29"><label>29</label>
Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</aff>
<aff id="A30"><label>30</label>
Department of Ophthalmology, Hospital Sestre Milosrdnice, Zagreb, Croatia</aff>
<aff id="A31"><label>31</label>
Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</aff>
<aff id="A32"><label>32</label>
Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</aff>
<aff id="A33"><label>33</label>
Southampton Eye Unit, Southampton General Hospital, Southampton, UK</aff>
<aff id="A34"><label>34</label>
Department of Public Health, University of Split, Split, Croatia</aff>
<aff id="A35"><label>35</label>
National Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, London, UK</aff>
<aff id="A36"><label>36</label>
Princess Alexandra Eye Pavilion, Edinburgh, UK</aff>
<aff id="A37"><label>37</label>
Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</aff>
<aff id="A38"><label>38</label>
Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, Washington, USA</aff>
<aff id="A39"><label>39</label>
Department of Medicine, Duke University, Durham, North Carolina, USA</aff>
<aff id="A40"><label>40</label>
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA</aff>
<aff id="A41"><label>41</label>
Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee, USA</aff>
<aff id="A42"><label>42</label>
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA</aff>
<aff id="A43"><label>43</label>
Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts, USA</aff>
<aff id="A44"><label>44</label>
Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA</aff>
<aff id="A45"><label>45</label>
Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA</aff>
<aff id="A46"><label>47</label>
Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia</aff>
<aff id="A47"><label>48</label>
Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA</aff>
<aff id="A48"><label>49</label>
Duke-National University of Singapore, Singapore</aff>
<aff id="A49"><label>50</label>
Queensland Institute of Medical Research, Genetic Epidemiology, Herston, Brisbane, Queensland, Australia</aff>
<aff id="A50"><label>51</label>
Queensland Institute of Medical Research, Molecular Epidemiology, Herston, Brisbane, Queensland, Australia</aff>
<aff id="A51"><label>52</label>
Department of Ophthamology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA</aff>
<aff id="A52"><label>53</label>
Singapore National Eye Centre, Singapore</aff>
<aff id="A53"><label>54</label>
Centre for Vision and Vascular Science, Queen’s University Belfast, Belfast, UK</aff>
<aff id="A54"><label>55</label>
Cornea Genetic Eye Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</aff>
<author-notes><corresp id="FN1">Correspondence should be addressed to S.M. (<email>stuart.macgregor@qimr.edu.au</email>
) or T.Y.W. (<email>tien_yin_wong@nuhs.edu.sg</email>
)</corresp>
<fn id="FN2"><label>46</label>
<p>A list of members is provided in the <xref rid="SD1" ref-type="supplementary-material">supplementary Note</xref>
.</p>
</fn>
<fn id="FN3" fn-type="equal"><label>56</label>
<p>These authors contributed equally to this work.</p>
</fn>
<fn id="FN4"><label>57</label>
<p>These authors jointly directed this work.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>24</day>
<month>6</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>06</day>
<month>1</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>2</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>2</month>
<year>2014</year>
</pub-date>
<volume>45</volume>
<issue>2</issue>
<fpage>155</fpage>
<lpage>163</lpage>
<permissions><copyright-statement>© 2013 Nature America, Inc. All rights reserved.</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract><p id="P1">Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma. We performed a meta-analysis on >20,000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide significance (<italic>P</italic>
< 5 × 10<sup>−8</sup>
). We further showed that 2 CCT-associated loci, <italic>FOXO1</italic>
and <italic>FNDC3B</italic>
, conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls (rs2721051 near <italic>FOXO1</italic>
had odds ratio (OR) = 1.62, 95% confidence interval (CI) = 1.4–1.88, <italic>P</italic>
= 2.7 × 10<sup>−10</sup>
, and rs4894535 in <italic>FNDC3B</italic>
had OR = 1.47, 95% CI = 1.29–1.68, <italic>P</italic>
= 4.9 × 10<sup>−9</sup>
). <italic>FNDC3B</italic>
was also associated with primary open-angle glaucoma (<italic>P</italic>
= 5.6 × 10<sup>−4</sup>
; tested in 3 cohorts with 2,979 cases and 7,399 controls). Further analyses implicate the collagen and extracellular matrix pathways in the regulation of CCT.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Eye Institute : NEI</funding-source>
<award-id>R01 EY018825 || EY</award-id>
</award-group>
<award-group><funding-source country="United States">National Eye Institute : NEI</funding-source>
<award-id>F32 EY021436 || EY</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Croatie</li>
<li>France</li>
<li>Hong Kong</li>
<li>Islande</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Singapour</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Californie</li>
<li>Caroline du Nord</li>
<li>Grand Londres</li>
<li>Hambourg</li>
<li>Hollande-Méridionale</li>
<li>Iowa</li>
<li>Massachusetts</li>
<li>Michigan</li>
<li>Nouvelle-Galles du Sud</li>
<li>Rhénanie-Palatinat</li>
<li>Tennessee</li>
<li>Victoria (État)</li>
<li>Washington (État)</li>
<li>Écosse</li>
<li>Île-de-France</li>
</region>
<settlement><li>Hambourg</li>
<li>Iowa City</li>
<li>Londres</li>
<li>Mayence</li>
<li>Melbourne</li>
<li>Paris</li>
<li>Rotterdam</li>
<li>Seattle</li>
<li>Sha Tin</li>
<li>Sydney</li>
<li>Édimbourg</li>
</settlement>
<orgName><li>Université chinoise de Hong Kong</li>
<li>Université d'Édimbourg</li>
<li>Université de Melbourne</li>
<li>Université de Sydney</li>
<li>Université de Washington</li>
<li>Université de l'Iowa</li>
<li>Université nationale de Singapour</li>
</orgName>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Lu, Yi" sort="Lu, Yi" uniqKey="Lu Y" first="Yi" last="Lu">Yi Lu</name>
</noRegion>
<name sortKey="Ang, Wei" sort="Ang, Wei" uniqKey="Ang W" first="Wei" last="Ang">Wei Ang</name>
<name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P" last="Burdon">Kathryn P. Burdon</name>
<name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name>
<name sortKey="Dimasi, David P" sort="Dimasi, David P" uniqKey="Dimasi D" first="David P" last="Dimasi">David P. Dimasi</name>
<name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name>
<name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name>
<name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name>
<name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name>
<name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name>
<name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
<name sortKey="Mills, Richard A" sort="Mills, Richard A" uniqKey="Mills R" first="Richard A" last="Mills">Richard A. Mills</name>
<name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name>
<name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name>
<name sortKey="Mountain, Jenny" sort="Mountain, Jenny" uniqKey="Mountain J" first="Jenny" last="Mountain">Jenny Mountain</name>
<name sortKey="Pennell, Craig" sort="Pennell, Craig" uniqKey="Pennell C" first="Craig" last="Pennell">Craig Pennell</name>
<name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name>
<name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name>
<name sortKey="Yazar, Seyhan" sort="Yazar, Seyhan" uniqKey="Yazar S" first="Seyhan" last="Yazar">Seyhan Yazar</name>
</country>
<country name="Royaume-Uni"><region name="Écosse"><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name>
</region>
<name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
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<name sortKey="Gibson, Jane" sort="Gibson, Jane" uniqKey="Gibson J" first="Jane" last="Gibson">Jane Gibson</name>
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<name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name>
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<name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea Chuen" last="Khor">Chiea Chuen Khor</name>
<name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea Chuen" last="Khor">Chiea Chuen Khor</name>
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