The MLL recombinome of acute leukemias in 2013
Identifieur interne : 001856 ( Pmc/Checkpoint ); précédent : 001855; suivant : 001857The MLL recombinome of acute leukemias in 2013
Auteurs : C. Meyer [Allemagne] ; J. Hofmann [Allemagne] ; T. Burmeister [Allemagne] ; D. Gröger [Allemagne] ; T S Park [Corée du Sud] ; M. Emerenciano [Brésil] ; M. Pombo De Oliveira [Brésil] ; A. Renneville [France] ; P. Villarese [France] ; E. Macintyre [France] ; H. Cavé [France] ; E. Clappier [France] ; K. Mass-Malo [France] ; J. Zuna [République tchèque] ; J. Trka [République tchèque] ; E. De Braekeleer [France] ; M. De Braekeleer [France] ; S H Oh [Corée du Sud] ; G. Tsaur [Russie] ; L. Fechina [Russie] ; V H J. Van Der Velden [Pays-Bas] ; J J M. Van Dongen [Pays-Bas] ; E. Delabesse [France] ; R. Binato [Brésil] ; M L M. Silva [Brésil] ; A. Kustanovich ; O. Aleinikova ; M H Harris [États-Unis] ; T. Lund-Aho [Finlande] ; V. Juvonen [Finlande] ; O. Heidenreich [Royaume-Uni] ; J. Vormoor [Royaume-Uni] ; W W L. Choi [République populaire de Chine] ; M. Jarosova [République tchèque] ; A. Kolenova [Slovaquie] ; C. Bueno [Espagne] ; P. Menendez [Espagne] ; S. Wehner [Allemagne] ; C. Eckert [Allemagne] ; P. Talmant [France] ; S. Tondeur [France] ; E. Lippert [France] ; E. Launay [France] ; C. Henry [France] ; P. Ballerini [France] ; H. Lapillone [France] ; M B Callanan [France] ; J M Cayuela [France] ; C. Herbaux [France] ; G. Cazzaniga [Italie] ; P M Kakadiya [Allemagne] ; S. Bohlander [Allemagne] ; M. Ahlmann [Allemagne] ; J R Choi [Corée du Sud] ; P. Gameiro [Portugal] ; D S Lee [Corée du Sud] ; J. Krauter [Allemagne] ; P. Cornillet-Lefebvre [France] ; G. Te Kronnie [Italie] ; B W Sch Fer [Suisse] ; S. Kubetzko [Suisse] ; C N Alonso [Argentine] ; U. Zur Stadt [Allemagne] ; R. Sutton [Australie] ; N C Venn [Australie] ; S. Izraeli [Israël] ; L. Trakhtenbrot [Israël] ; H O Madsen [Danemark] ; P. Archer [Royaume-Uni] ; J. Hancock [Royaume-Uni] ; N. Cerveira [Portugal] ; M R Teixeira [Portugal] ; L. Lo Nigro [Italie] ; A. Möricke [Allemagne] ; M. Stanulla [Allemagne] ; M. Schrappe [Allemagne] ; L. Sedék [Pologne] ; T. Szczepa Ski [Pologne] ; C M Zwaan [Pays-Bas] ; E A Coenen [Pays-Bas] ; M M Van Den Heuvel-Eibrink [Pays-Bas] ; S. Strehl [Autriche] ; M. Dworzak [Autriche] ; R. Panzer-Grümayer [Autriche] ; T. Dingermann [Allemagne] ; T. Klingebiel [Allemagne] ; R. Marschalek [Allemagne]Source :
- Leukemia [ 0887-6924 ] ; 2013.
Abstract
Chromosomal rearrangements of the human
Url:
DOI: 10.1038/leu.2013.135
PubMed: 23628958
PubMed Central: 3826032
Affiliations:
- Allemagne, Argentine, Australie, Autriche, Brésil, Corée du Sud, Danemark, Espagne, Finlande, France, Israël, Italie, Pays-Bas, Pologne, Portugal, Royaume-Uni, Russie, République populaire de Chine, République tchèque, Slovaquie, Suisse, États-Unis
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PMC:3826032Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The <italic>MLL</italic>
recombinome of acute leukemias in 2013</title>
<author><name sortKey="Meyer, C" sort="Meyer, C" uniqKey="Meyer C" first="C" last="Meyer">C. Meyer</name>
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, Frankfurt/Main,<country>Germany</country>
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<country xml:lang="fr">Allemagne</country>
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, Frankfurt/Main,<country>Germany</country>
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<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Burmeister, T" sort="Burmeister, T" uniqKey="Burmeister T" first="T" last="Burmeister">T. Burmeister</name>
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<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Groger, D" sort="Groger, D" uniqKey="Groger D" first="D" last="Gröger">D. Gröger</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Park, T S" sort="Park, T S" uniqKey="Park T" first="T S" last="Park">T S Park</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Laboratory Medicine, School of Medicine, Kyung Hee University</institution>
, Seoul,<country>Korea</country>
</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Emerenciano, M" sort="Emerenciano, M" uniqKey="Emerenciano M" first="M" last="Emerenciano">M. Emerenciano</name>
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, Rio de Janeiro,<country>Brazil</country>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Pombo De Oliveira, M" sort="Pombo De Oliveira, M" uniqKey="Pombo De Oliveira M" first="M" last="Pombo De Oliveira">M. Pombo De Oliveira</name>
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, Rio de Janeiro,<country>Brazil</country>
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<country xml:lang="fr">Brésil</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Renneville, A" sort="Renneville, A" uniqKey="Renneville A" first="A" last="Renneville">A. Renneville</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Laboratory of Hematology, Biology and Pathology Center, CHRU of Lille; INSERM-U837, Team 3, Cancer Research Institute of Lille</institution>
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</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Villarese, P" sort="Villarese, P" uniqKey="Villarese P" first="P" last="Villarese">P. Villarese</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Biological Hematology, AP-HP Necker-Enfants Malades, Université Paris-Descartes</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Macintyre, E" sort="Macintyre, E" uniqKey="Macintyre E" first="E" last="Macintyre">E. Macintyre</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Biological Hematology, AP-HP Necker-Enfants Malades, Université Paris-Descartes</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Cave, H" sort="Cave, H" uniqKey="Cave H" first="H" last="Cavé">H. Cavé</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Genetics, AP-HP Robert Debré, Paris Diderot University</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Clappier, E" sort="Clappier, E" uniqKey="Clappier E" first="E" last="Clappier">E. Clappier</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Genetics, AP-HP Robert Debré, Paris Diderot University</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Mass Malo, K" sort="Mass Malo, K" uniqKey="Mass Malo K" first="K" last="Mass-Malo">K. Mass-Malo</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Genetics, AP-HP Robert Debré, Paris Diderot University</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zuna, J" sort="Zuna, J" uniqKey="Zuna J" first="J" last="Zuna">J. Zuna</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, Second Faculty of Medicine</institution>
, Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Trka, J" sort="Trka, J" uniqKey="Trka J" first="J" last="Trka">J. Trka</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, Second Faculty of Medicine</institution>
, Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="De Braekeleer, E" sort="De Braekeleer, E" uniqKey="De Braekeleer E" first="E" last="De Braekeleer">E. De Braekeleer</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, Laboratoire d'Histologie, Embryologie et Cytogénétique and INSERM-U1078</institution>
, Brest,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Braekeleer, M" sort="De Braekeleer, M" uniqKey="De Braekeleer M" first="M" last="De Braekeleer">M. De Braekeleer</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, Laboratoire d'Histologie, Embryologie et Cytogénétique and INSERM-U1078</institution>
, Brest,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oh, S H" sort="Oh, S H" uniqKey="Oh S" first="S H" last="Oh">S H Oh</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Laboratory Medicine, Inje University College of Medicine</institution>
, Busan,<country>Korea</country>
</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tsaur, G" sort="Tsaur, G" uniqKey="Tsaur G" first="G" last="Tsaur">G. Tsaur</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center</institution>
, Ekaterinburg,<country>Russia</country>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Fechina, L" sort="Fechina, L" uniqKey="Fechina L" first="L" last="Fechina">L. Fechina</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center</institution>
, Ekaterinburg,<country>Russia</country>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Velden, V H J" sort="Van Der Velden, V H J" uniqKey="Van Der Velden V" first="V H J" last="Van Der Velden">V H J. Van Der Velden</name>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Erasmus MC, Department of Immunology</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Dongen, J J M" sort="Van Dongen, J J M" uniqKey="Van Dongen J" first="J J M" last="Van Dongen">J J M. Van Dongen</name>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Erasmus MC, Department of Immunology</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Delabesse, E" sort="Delabesse, E" uniqKey="Delabesse E" first="E" last="Delabesse">E. Delabesse</name>
<affiliation wicri:level="1"><nlm:aff id="aff13"><institution>CHU Purpan, Laboratoire d'Hématologie</institution>
, Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Binato, R" sort="Binato, R" uniqKey="Binato R" first="R" last="Binato">R. Binato</name>
<affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Lab. Célula tronco-CEMO-INCA</institution>
, Rio de Janeiro,<country>Brazil</country>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Silva, M L M" sort="Silva, M L M" uniqKey="Silva M" first="M L M" last="Silva">M L M. Silva</name>
<affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Lab. Citogenética-CEMO-INCA</institution>
, Rio de Janeiro,<country>Brazil</country>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kustanovich, A" sort="Kustanovich, A" uniqKey="Kustanovich A" first="A" last="Kustanovich">A. Kustanovich</name>
<affiliation><nlm:aff id="aff16"><institution>Belarusian Research Center for Pediatric Oncology, Hematology and Immunology</institution>
, Minsk,<country>Republic of Belarus</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Republic of Belarus</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Aleinikova, O" sort="Aleinikova, O" uniqKey="Aleinikova O" first="O" last="Aleinikova">O. Aleinikova</name>
<affiliation><nlm:aff id="aff16"><institution>Belarusian Research Center for Pediatric Oncology, Hematology and Immunology</institution>
, Minsk,<country>Republic of Belarus</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Republic of Belarus</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Harris, M H" sort="Harris, M H" uniqKey="Harris M" first="M H" last="Harris">M H Harris</name>
<affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Departments of Pathology and Laboratory Medicine, Boston Children's Hospital</institution>
, Boston, MA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lund Aho, T" sort="Lund Aho, T" uniqKey="Lund Aho T" first="T" last="Lund-Aho">T. Lund-Aho</name>
<affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Laboratory of Clinical Genetics, Fimlab Laboratories</institution>
, Tampere,<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Juvonen, V" sort="Juvonen, V" uniqKey="Juvonen V" first="V" last="Juvonen">V. Juvonen</name>
<affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Department of Clinical Chemistry and TYKSLAB, University of Turku and Turku University Central Hospital</institution>
, Turku,<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heidenreich, O" sort="Heidenreich, O" uniqKey="Heidenreich O" first="O" last="Heidenreich">O. Heidenreich</name>
<affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Northern Institute for Cancer Research, Newcastle University</institution>
, Newcastle upon Tyne,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vormoor, J" sort="Vormoor, J" uniqKey="Vormoor J" first="J" last="Vormoor">J. Vormoor</name>
<affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Northern Institute for Cancer Research, Newcastle University and the Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust</institution>
, Newcastle upon Tyne,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Choi, W W L" sort="Choi, W W L" uniqKey="Choi W" first="W W L" last="Choi">W W L. Choi</name>
<affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</institution>
, Hong Kong,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jarosova, M" sort="Jarosova, M" uniqKey="Jarosova M" first="M" last="Jarosova">M. Jarosova</name>
<affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc</institution>
, Olomouc,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kolenova, A" sort="Kolenova, A" uniqKey="Kolenova A" first="A" last="Kolenova">A. Kolenova</name>
<affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Department of Pediatric Hematology and Oncology, University Childrens' Hospital and Medical School of Comenius University</institution>
, Bratislava,<country>Slovakia</country>
</nlm:aff>
<country xml:lang="fr">Slovaquie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bueno, C" sort="Bueno, C" uniqKey="Bueno C" first="C" last="Bueno">C. Bueno</name>
<affiliation wicri:level="1"><nlm:aff id="aff25"><institution>GENyO, Centre for Genomics and Oncological Research: Pfizer, Universidad de Granada, Junta de Andalucia, Granada and Josep Carreras Leukemia Research Institute/Cell Therapy Program University of Barcelona</institution>
, Barcelona,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Menendez, P" sort="Menendez, P" uniqKey="Menendez P" first="P" last="Menendez">P. Menendez</name>
<affiliation wicri:level="1"><nlm:aff id="aff25"><institution>GENyO, Centre for Genomics and Oncological Research: Pfizer, Universidad de Granada, Junta de Andalucia, Granada and Josep Carreras Leukemia Research Institute/Cell Therapy Program University of Barcelona</institution>
, Barcelona,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wehner, S" sort="Wehner, S" uniqKey="Wehner S" first="S" last="Wehner">S. Wehner</name>
<affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Pediatric Hematology and Oncology, University of Frankfurt</institution>
, Frankfurt,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eckert, C" sort="Eckert, C" uniqKey="Eckert C" first="C" last="Eckert">C. Eckert</name>
<affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Charité-Department of Pediatric Oncology and Hematology</institution>
, Berlin,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Talmant, P" sort="Talmant, P" uniqKey="Talmant P" first="P" last="Talmant">P. Talmant</name>
<affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Department of Hematology, Centre Hospitalier Universitaire</institution>
, Nantes,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tondeur, S" sort="Tondeur, S" uniqKey="Tondeur S" first="S" last="Tondeur">S. Tondeur</name>
<affiliation wicri:level="1"><nlm:aff id="aff29"><institution>CHU Montpellier, Institute for Research in Biotherapy, Laboratory of Hematology, Hôpital Saint-Eloi and NSERM-U847</institution>
, Montpellier,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lippert, E" sort="Lippert, E" uniqKey="Lippert E" first="E" last="Lippert">E. Lippert</name>
<affiliation wicri:level="1"><nlm:aff id="aff30"><institution>Laboratoire d'Hématologie, CHU de Bordeaux</institution>
, Bordeaux,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Launay, E" sort="Launay, E" uniqKey="Launay E" first="E" last="Launay">E. Launay</name>
<affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Service de Cytogénétique et de Biologie Cellulaire, CHU de Rennes, Hôpital Pontchaillou</institution>
, Rennes,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Henry, C" sort="Henry, C" uniqKey="Henry C" first="C" last="Henry">C. Henry</name>
<affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Service de Cytogénétique et de Biologie Cellulaire, CHU de Rennes, Hôpital Pontchaillou</institution>
, Rennes,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ballerini, P" sort="Ballerini, P" uniqKey="Ballerini P" first="P" last="Ballerini">P. Ballerini</name>
<affiliation wicri:level="1"><nlm:aff id="aff32"><institution>Biological Hematology, AP-HP A Trousseau, Pierre et Marie Curie University</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lapillone, H" sort="Lapillone, H" uniqKey="Lapillone H" first="H" last="Lapillone">H. Lapillone</name>
<affiliation wicri:level="1"><nlm:aff id="aff32"><institution>Biological Hematology, AP-HP A Trousseau, Pierre et Marie Curie University</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Callanan, M B" sort="Callanan, M B" uniqKey="Callanan M" first="M B" last="Callanan">M B Callanan</name>
<affiliation wicri:level="1"><nlm:aff id="aff33"><institution>INSERM-U823, Oncogenic Pathways in the Haematological Malignancies, Institut Albert Bonniot</institution>
, Grenoble,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cayuela, J M" sort="Cayuela, J M" uniqKey="Cayuela J" first="J M" last="Cayuela">J M Cayuela</name>
<affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Laboratoire d'Hématologie, AP-HP Saint-Louis, Paris Diderot University</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Herbaux, C" sort="Herbaux, C" uniqKey="Herbaux C" first="C" last="Herbaux">C. Herbaux</name>
<affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Service d'Hématologie Immunologie Cytogénétique, Centre Hospitalier de Valenciennes</institution>
, Valenciennes,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cazzaniga, G" sort="Cazzaniga, G" uniqKey="Cazzaniga G" first="G" last="Cazzaniga">G. Cazzaniga</name>
<affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Centro Ricerca Tettamanti, Clinica Pediatrica Univ. Milano Bicocca</institution>
, Monza,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kakadiya, P M" sort="Kakadiya, P M" uniqKey="Kakadiya P" first="P M" last="Kakadiya">P M Kakadiya</name>
<affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Center for Human Genetics, Philipps University Marburg</institution>
, Marburg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bohlander, S" sort="Bohlander, S" uniqKey="Bohlander S" first="S" last="Bohlander">S. Bohlander</name>
<affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Center for Human Genetics, Philipps University Marburg</institution>
, Marburg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ahlmann, M" sort="Ahlmann, M" uniqKey="Ahlmann M" first="M" last="Ahlmann">M. Ahlmann</name>
<affiliation wicri:level="1"><nlm:aff id="aff38"><institution>University Childrens Hospital Muenster, Pediatric Hematology and Oncology</institution>
, Muenster,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Choi, J R" sort="Choi, J R" uniqKey="Choi J" first="J R" last="Choi">J R Choi</name>
<affiliation wicri:level="1"><nlm:aff id="aff39"><institution>Department of Laboratory Medicine, Yonsei University College of Medicine</institution>
, Seoul,<country>Korea</country>
</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gameiro, P" sort="Gameiro, P" uniqKey="Gameiro P" first="P" last="Gameiro">P. Gameiro</name>
<affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Hemato-Oncology Laboratory, UIPM, Portuguese Institute of Oncology of Lisbon</institution>
, Lisbon,<country>Portugal</country>
</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, D S" sort="Lee, D S" uniqKey="Lee D" first="D S" last="Lee">D S Lee</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Laboratory Medicine, Seoul National University College of Medicine</institution>
, Seoul,<country>Korea</country>
</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krauter, J" sort="Krauter, J" uniqKey="Krauter J" first="J" last="Krauter">J. Krauter</name>
<affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Hannover Medical School, Clinic for Hematology, Hemostasis, Oncology and Stem Cell Transplantation</institution>
, Hannover,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cornillet Lefebvre, P" sort="Cornillet Lefebvre, P" uniqKey="Cornillet Lefebvre P" first="P" last="Cornillet-Lefebvre">P. Cornillet-Lefebvre</name>
<affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Laboratoire d'Hématologie, Hôpital Robert-Debré</institution>
, Reims,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Te Kronnie, G" sort="Te Kronnie, G" uniqKey="Te Kronnie G" first="G" last="Te Kronnie">G. Te Kronnie</name>
<affiliation wicri:level="1"><nlm:aff id="aff44"><institution>Department of Women's and Children's Health, University of Padova</institution>
, Padova,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sch Fer, B W" sort="Sch Fer, B W" uniqKey="Sch Fer B" first="B W" last="Sch Fer">B W Sch Fer</name>
<affiliation wicri:level="1"><nlm:aff id="aff45"><institution>University Children's Hospital Zurich, Department of Oncology</institution>
, Zurich,<country>Switzerland</country>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kubetzko, S" sort="Kubetzko, S" uniqKey="Kubetzko S" first="S" last="Kubetzko">S. Kubetzko</name>
<affiliation wicri:level="1"><nlm:aff id="aff45"><institution>University Children's Hospital Zurich, Department of Oncology</institution>
, Zurich,<country>Switzerland</country>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alonso, C N" sort="Alonso, C N" uniqKey="Alonso C" first="C N" last="Alonso">C N Alonso</name>
<affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Hospital Nacional de Pediatría Professor Dr JP Garrahan, Servcio de Hemato-Oncología</institution>
, Buenos Aires,<country>Argentina</country>
</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zur Stadt, U" sort="Zur Stadt, U" uniqKey="Zur Stadt U" first="U" last="Zur Stadt">U. Zur Stadt</name>
<affiliation wicri:level="1"><nlm:aff id="aff47"><institution>Center for Diagnostic, University Medical Center Hamburg Eppendorf</institution>
, Hamburg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sutton, R" sort="Sutton, R" uniqKey="Sutton R" first="R" last="Sutton">R. Sutton</name>
<affiliation wicri:level="1"><nlm:aff id="aff48"><institution>Children's Cancer Institute Australia, University of New South Wales</institution>
, Sydney, New South Wales,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Venn, N C" sort="Venn, N C" uniqKey="Venn N" first="N C" last="Venn">N C Venn</name>
<affiliation wicri:level="1"><nlm:aff id="aff48"><institution>Children's Cancer Institute Australia, University of New South Wales</institution>
, Sydney, New South Wales,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Izraeli, S" sort="Izraeli, S" uniqKey="Izraeli S" first="S" last="Izraeli">S. Izraeli</name>
<affiliation wicri:level="1"><nlm:aff id="aff49"><institution>The Chaim Sheba Medical Center, Department of Pediatric Hemato-Oncology and the Cancer Research Center, and Sackler Medical School Tel Aviv University</institution>
, Tel Aviv,<country>Israel</country>
</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Trakhtenbrot, L" sort="Trakhtenbrot, L" uniqKey="Trakhtenbrot L" first="L" last="Trakhtenbrot">L. Trakhtenbrot</name>
<affiliation wicri:level="1"><nlm:aff id="aff49"><institution>The Chaim Sheba Medical Center, Department of Pediatric Hemato-Oncology and the Cancer Research Center, and Sackler Medical School Tel Aviv University</institution>
, Tel Aviv,<country>Israel</country>
</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Madsen, H O" sort="Madsen, H O" uniqKey="Madsen H" first="H O" last="Madsen">H O Madsen</name>
<affiliation wicri:level="1"><nlm:aff id="aff50"><institution>Department of Clinical Immunology, University Hospital Rigshospitalet</institution>
, Copenhagen,<country>Denmark</country>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Archer, P" sort="Archer, P" uniqKey="Archer P" first="P" last="Archer">P. Archer</name>
<affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Bristol Genetics Laboratory, Pathology Sciences, Southmead Hospital, North Bristol NHS Trust</institution>
, Bristol,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hancock, J" sort="Hancock, J" uniqKey="Hancock J" first="J" last="Hancock">J. Hancock</name>
<affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Bristol Genetics Laboratory, Pathology Sciences, Southmead Hospital, North Bristol NHS Trust</institution>
, Bristol,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cerveira, N" sort="Cerveira, N" uniqKey="Cerveira N" first="N" last="Cerveira">N. Cerveira</name>
<affiliation wicri:level="1"><nlm:aff id="aff52"><institution>Department of Genetics, Portuguese Oncology Institute-Porto, and Biomedical Sciences Institute (ICBAS), University of Porto</institution>
, Porto,<country>Portugal</country>
</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Teixeira, M R" sort="Teixeira, M R" uniqKey="Teixeira M" first="M R" last="Teixeira">M R Teixeira</name>
<affiliation wicri:level="1"><nlm:aff id="aff52"><institution>Department of Genetics, Portuguese Oncology Institute-Porto, and Biomedical Sciences Institute (ICBAS), University of Porto</institution>
, Porto,<country>Portugal</country>
</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lo Nigro, L" sort="Lo Nigro, L" uniqKey="Lo Nigro L" first="L" last="Lo Nigro">L. Lo Nigro</name>
<affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Center of Pediatric Hematology Oncology, University of Catania</institution>
, Catania,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moricke, A" sort="Moricke, A" uniqKey="Moricke A" first="A" last="Möricke">A. Möricke</name>
<affiliation wicri:level="1"><nlm:aff id="aff54"><institution>Department of Pediatrics, University Medical Centre Schleswig-Holstein</institution>
, Kiel,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stanulla, M" sort="Stanulla, M" uniqKey="Stanulla M" first="M" last="Stanulla">M. Stanulla</name>
<affiliation wicri:level="1"><nlm:aff id="aff54"><institution>Department of Pediatrics, University Medical Centre Schleswig-Holstein</institution>
, Kiel,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schrappe, M" sort="Schrappe, M" uniqKey="Schrappe M" first="M" last="Schrappe">M. Schrappe</name>
<affiliation wicri:level="1"><nlm:aff id="aff54"><institution>Department of Pediatrics, University Medical Centre Schleswig-Holstein</institution>
, Kiel,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sedek, L" sort="Sedek, L" uniqKey="Sedek L" first="L" last="Sedék">L. Sedék</name>
<affiliation wicri:level="1"><nlm:aff id="aff55"><institution>Department of Pediatric Hematology and Oncology, Medical University of Silesia</institution>
, Zabrze,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Szczepa Ski, T" sort="Szczepa Ski, T" uniqKey="Szczepa Ski T" first="T" last="Szczepa Ski">T. Szczepa Ski</name>
<affiliation wicri:level="1"><nlm:aff id="aff55"><institution>Department of Pediatric Hematology and Oncology, Medical University of Silesia</institution>
, Zabrze,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zwaan, C M" sort="Zwaan, C M" uniqKey="Zwaan C" first="C M" last="Zwaan">C M Zwaan</name>
<affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Erasmus MC, Sophia Children's Hospital, Department of Pediatric Oncology/Hematology</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Coenen, E A" sort="Coenen, E A" uniqKey="Coenen E" first="E A" last="Coenen">E A Coenen</name>
<affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Erasmus MC, Sophia Children's Hospital, Department of Pediatric Oncology/Hematology</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Den Heuvel Eibrink, M M" sort="Van Den Heuvel Eibrink, M M" uniqKey="Van Den Heuvel Eibrink M" first="M M" last="Van Den Heuvel-Eibrink">M M Van Den Heuvel-Eibrink</name>
<affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Erasmus MC, Sophia Children's Hospital, Department of Pediatric Oncology/Hematology</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Strehl, S" sort="Strehl, S" uniqKey="Strehl S" first="S" last="Strehl">S. Strehl</name>
<affiliation wicri:level="1"><nlm:aff id="aff57"><institution>Children's Cancer Research Institute and Medical University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dworzak, M" sort="Dworzak, M" uniqKey="Dworzak M" first="M" last="Dworzak">M. Dworzak</name>
<affiliation wicri:level="1"><nlm:aff id="aff57"><institution>Children's Cancer Research Institute and Medical University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Panzer Grumayer, R" sort="Panzer Grumayer, R" uniqKey="Panzer Grumayer R" first="R" last="Panzer-Grümayer">R. Panzer-Grümayer</name>
<affiliation wicri:level="1"><nlm:aff id="aff57"><institution>Children's Cancer Research Institute and Medical University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dingermann, T" sort="Dingermann, T" uniqKey="Dingermann T" first="T" last="Dingermann">T. Dingermann</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Biochemistry, Chemistry and Pharmacy, Institute of Pharmaceutical Biology/ZAFES/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University of Frankfurt</institution>
, Frankfurt/Main,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klingebiel, T" sort="Klingebiel, T" uniqKey="Klingebiel T" first="T" last="Klingebiel">T. Klingebiel</name>
<affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Pediatric Hematology and Oncology, University of Frankfurt</institution>
, Frankfurt,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marschalek, R" sort="Marschalek, R" uniqKey="Marschalek R" first="R" last="Marschalek">R. Marschalek</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Biochemistry, Chemistry and Pharmacy, Institute of Pharmaceutical Biology/ZAFES/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University of Frankfurt</institution>
, Frankfurt/Main,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23628958</idno>
<idno type="pmc">3826032</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826032</idno>
<idno type="RBID">PMC:3826032</idno>
<idno type="doi">10.1038/leu.2013.135</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000099</idno>
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<idno type="wicri:Area/Pmc/Curation">000099</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000099</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001856</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001856</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The <italic>MLL</italic>
recombinome of acute leukemias in 2013</title>
<author><name sortKey="Meyer, C" sort="Meyer, C" uniqKey="Meyer C" first="C" last="Meyer">C. Meyer</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Biochemistry, Chemistry and Pharmacy, Institute of Pharmaceutical Biology/ZAFES/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University of Frankfurt</institution>
, Frankfurt/Main,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hofmann, J" sort="Hofmann, J" uniqKey="Hofmann J" first="J" last="Hofmann">J. Hofmann</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Biochemistry, Chemistry and Pharmacy, Institute of Pharmaceutical Biology/ZAFES/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University of Frankfurt</institution>
, Frankfurt/Main,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Burmeister, T" sort="Burmeister, T" uniqKey="Burmeister T" first="T" last="Burmeister">T. Burmeister</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Charité-Department of Hematology, Oncology and Tumor Immunology</institution>
, Berlin,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Groger, D" sort="Groger, D" uniqKey="Groger D" first="D" last="Gröger">D. Gröger</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Charité-Department of Hematology, Oncology and Tumor Immunology</institution>
, Berlin,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, T S" sort="Park, T S" uniqKey="Park T" first="T S" last="Park">T S Park</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Laboratory Medicine, School of Medicine, Kyung Hee University</institution>
, Seoul,<country>Korea</country>
</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Emerenciano, M" sort="Emerenciano, M" uniqKey="Emerenciano M" first="M" last="Emerenciano">M. Emerenciano</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro</institution>
, Rio de Janeiro,<country>Brazil</country>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pombo De Oliveira, M" sort="Pombo De Oliveira, M" uniqKey="Pombo De Oliveira M" first="M" last="Pombo De Oliveira">M. Pombo De Oliveira</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro</institution>
, Rio de Janeiro,<country>Brazil</country>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Renneville, A" sort="Renneville, A" uniqKey="Renneville A" first="A" last="Renneville">A. Renneville</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Laboratory of Hematology, Biology and Pathology Center, CHRU of Lille; INSERM-U837, Team 3, Cancer Research Institute of Lille</institution>
, Lille,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Villarese, P" sort="Villarese, P" uniqKey="Villarese P" first="P" last="Villarese">P. Villarese</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Biological Hematology, AP-HP Necker-Enfants Malades, Université Paris-Descartes</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Macintyre, E" sort="Macintyre, E" uniqKey="Macintyre E" first="E" last="Macintyre">E. Macintyre</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Biological Hematology, AP-HP Necker-Enfants Malades, Université Paris-Descartes</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cave, H" sort="Cave, H" uniqKey="Cave H" first="H" last="Cavé">H. Cavé</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Genetics, AP-HP Robert Debré, Paris Diderot University</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Clappier, E" sort="Clappier, E" uniqKey="Clappier E" first="E" last="Clappier">E. Clappier</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Genetics, AP-HP Robert Debré, Paris Diderot University</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mass Malo, K" sort="Mass Malo, K" uniqKey="Mass Malo K" first="K" last="Mass-Malo">K. Mass-Malo</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Genetics, AP-HP Robert Debré, Paris Diderot University</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zuna, J" sort="Zuna, J" uniqKey="Zuna J" first="J" last="Zuna">J. Zuna</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, Second Faculty of Medicine</institution>
, Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Trka, J" sort="Trka, J" uniqKey="Trka J" first="J" last="Trka">J. Trka</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, Second Faculty of Medicine</institution>
, Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Braekeleer, E" sort="De Braekeleer, E" uniqKey="De Braekeleer E" first="E" last="De Braekeleer">E. De Braekeleer</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, Laboratoire d'Histologie, Embryologie et Cytogénétique and INSERM-U1078</institution>
, Brest,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Braekeleer, M" sort="De Braekeleer, M" uniqKey="De Braekeleer M" first="M" last="De Braekeleer">M. De Braekeleer</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, Laboratoire d'Histologie, Embryologie et Cytogénétique and INSERM-U1078</institution>
, Brest,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oh, S H" sort="Oh, S H" uniqKey="Oh S" first="S H" last="Oh">S H Oh</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Laboratory Medicine, Inje University College of Medicine</institution>
, Busan,<country>Korea</country>
</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tsaur, G" sort="Tsaur, G" uniqKey="Tsaur G" first="G" last="Tsaur">G. Tsaur</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center</institution>
, Ekaterinburg,<country>Russia</country>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fechina, L" sort="Fechina, L" uniqKey="Fechina L" first="L" last="Fechina">L. Fechina</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center</institution>
, Ekaterinburg,<country>Russia</country>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Velden, V H J" sort="Van Der Velden, V H J" uniqKey="Van Der Velden V" first="V H J" last="Van Der Velden">V H J. Van Der Velden</name>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Erasmus MC, Department of Immunology</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Dongen, J J M" sort="Van Dongen, J J M" uniqKey="Van Dongen J" first="J J M" last="Van Dongen">J J M. Van Dongen</name>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Erasmus MC, Department of Immunology</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Delabesse, E" sort="Delabesse, E" uniqKey="Delabesse E" first="E" last="Delabesse">E. Delabesse</name>
<affiliation wicri:level="1"><nlm:aff id="aff13"><institution>CHU Purpan, Laboratoire d'Hématologie</institution>
, Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Binato, R" sort="Binato, R" uniqKey="Binato R" first="R" last="Binato">R. Binato</name>
<affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Lab. Célula tronco-CEMO-INCA</institution>
, Rio de Janeiro,<country>Brazil</country>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Silva, M L M" sort="Silva, M L M" uniqKey="Silva M" first="M L M" last="Silva">M L M. Silva</name>
<affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Lab. Citogenética-CEMO-INCA</institution>
, Rio de Janeiro,<country>Brazil</country>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kustanovich, A" sort="Kustanovich, A" uniqKey="Kustanovich A" first="A" last="Kustanovich">A. Kustanovich</name>
<affiliation><nlm:aff id="aff16"><institution>Belarusian Research Center for Pediatric Oncology, Hematology and Immunology</institution>
, Minsk,<country>Republic of Belarus</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Republic of Belarus</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Aleinikova, O" sort="Aleinikova, O" uniqKey="Aleinikova O" first="O" last="Aleinikova">O. Aleinikova</name>
<affiliation><nlm:aff id="aff16"><institution>Belarusian Research Center for Pediatric Oncology, Hematology and Immunology</institution>
, Minsk,<country>Republic of Belarus</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Republic of Belarus</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Harris, M H" sort="Harris, M H" uniqKey="Harris M" first="M H" last="Harris">M H Harris</name>
<affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Departments of Pathology and Laboratory Medicine, Boston Children's Hospital</institution>
, Boston, MA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lund Aho, T" sort="Lund Aho, T" uniqKey="Lund Aho T" first="T" last="Lund-Aho">T. Lund-Aho</name>
<affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Laboratory of Clinical Genetics, Fimlab Laboratories</institution>
, Tampere,<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Juvonen, V" sort="Juvonen, V" uniqKey="Juvonen V" first="V" last="Juvonen">V. Juvonen</name>
<affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Department of Clinical Chemistry and TYKSLAB, University of Turku and Turku University Central Hospital</institution>
, Turku,<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heidenreich, O" sort="Heidenreich, O" uniqKey="Heidenreich O" first="O" last="Heidenreich">O. Heidenreich</name>
<affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Northern Institute for Cancer Research, Newcastle University</institution>
, Newcastle upon Tyne,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vormoor, J" sort="Vormoor, J" uniqKey="Vormoor J" first="J" last="Vormoor">J. Vormoor</name>
<affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Northern Institute for Cancer Research, Newcastle University and the Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust</institution>
, Newcastle upon Tyne,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Choi, W W L" sort="Choi, W W L" uniqKey="Choi W" first="W W L" last="Choi">W W L. Choi</name>
<affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</institution>
, Hong Kong,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jarosova, M" sort="Jarosova, M" uniqKey="Jarosova M" first="M" last="Jarosova">M. Jarosova</name>
<affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc</institution>
, Olomouc,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kolenova, A" sort="Kolenova, A" uniqKey="Kolenova A" first="A" last="Kolenova">A. Kolenova</name>
<affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Department of Pediatric Hematology and Oncology, University Childrens' Hospital and Medical School of Comenius University</institution>
, Bratislava,<country>Slovakia</country>
</nlm:aff>
<country xml:lang="fr">Slovaquie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bueno, C" sort="Bueno, C" uniqKey="Bueno C" first="C" last="Bueno">C. Bueno</name>
<affiliation wicri:level="1"><nlm:aff id="aff25"><institution>GENyO, Centre for Genomics and Oncological Research: Pfizer, Universidad de Granada, Junta de Andalucia, Granada and Josep Carreras Leukemia Research Institute/Cell Therapy Program University of Barcelona</institution>
, Barcelona,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Menendez, P" sort="Menendez, P" uniqKey="Menendez P" first="P" last="Menendez">P. Menendez</name>
<affiliation wicri:level="1"><nlm:aff id="aff25"><institution>GENyO, Centre for Genomics and Oncological Research: Pfizer, Universidad de Granada, Junta de Andalucia, Granada and Josep Carreras Leukemia Research Institute/Cell Therapy Program University of Barcelona</institution>
, Barcelona,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wehner, S" sort="Wehner, S" uniqKey="Wehner S" first="S" last="Wehner">S. Wehner</name>
<affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Pediatric Hematology and Oncology, University of Frankfurt</institution>
, Frankfurt,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eckert, C" sort="Eckert, C" uniqKey="Eckert C" first="C" last="Eckert">C. Eckert</name>
<affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Charité-Department of Pediatric Oncology and Hematology</institution>
, Berlin,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Talmant, P" sort="Talmant, P" uniqKey="Talmant P" first="P" last="Talmant">P. Talmant</name>
<affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Department of Hematology, Centre Hospitalier Universitaire</institution>
, Nantes,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tondeur, S" sort="Tondeur, S" uniqKey="Tondeur S" first="S" last="Tondeur">S. Tondeur</name>
<affiliation wicri:level="1"><nlm:aff id="aff29"><institution>CHU Montpellier, Institute for Research in Biotherapy, Laboratory of Hematology, Hôpital Saint-Eloi and NSERM-U847</institution>
, Montpellier,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lippert, E" sort="Lippert, E" uniqKey="Lippert E" first="E" last="Lippert">E. Lippert</name>
<affiliation wicri:level="1"><nlm:aff id="aff30"><institution>Laboratoire d'Hématologie, CHU de Bordeaux</institution>
, Bordeaux,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Launay, E" sort="Launay, E" uniqKey="Launay E" first="E" last="Launay">E. Launay</name>
<affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Service de Cytogénétique et de Biologie Cellulaire, CHU de Rennes, Hôpital Pontchaillou</institution>
, Rennes,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Henry, C" sort="Henry, C" uniqKey="Henry C" first="C" last="Henry">C. Henry</name>
<affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Service de Cytogénétique et de Biologie Cellulaire, CHU de Rennes, Hôpital Pontchaillou</institution>
, Rennes,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ballerini, P" sort="Ballerini, P" uniqKey="Ballerini P" first="P" last="Ballerini">P. Ballerini</name>
<affiliation wicri:level="1"><nlm:aff id="aff32"><institution>Biological Hematology, AP-HP A Trousseau, Pierre et Marie Curie University</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lapillone, H" sort="Lapillone, H" uniqKey="Lapillone H" first="H" last="Lapillone">H. Lapillone</name>
<affiliation wicri:level="1"><nlm:aff id="aff32"><institution>Biological Hematology, AP-HP A Trousseau, Pierre et Marie Curie University</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Callanan, M B" sort="Callanan, M B" uniqKey="Callanan M" first="M B" last="Callanan">M B Callanan</name>
<affiliation wicri:level="1"><nlm:aff id="aff33"><institution>INSERM-U823, Oncogenic Pathways in the Haematological Malignancies, Institut Albert Bonniot</institution>
, Grenoble,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cayuela, J M" sort="Cayuela, J M" uniqKey="Cayuela J" first="J M" last="Cayuela">J M Cayuela</name>
<affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Laboratoire d'Hématologie, AP-HP Saint-Louis, Paris Diderot University</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Herbaux, C" sort="Herbaux, C" uniqKey="Herbaux C" first="C" last="Herbaux">C. Herbaux</name>
<affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Service d'Hématologie Immunologie Cytogénétique, Centre Hospitalier de Valenciennes</institution>
, Valenciennes,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cazzaniga, G" sort="Cazzaniga, G" uniqKey="Cazzaniga G" first="G" last="Cazzaniga">G. Cazzaniga</name>
<affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Centro Ricerca Tettamanti, Clinica Pediatrica Univ. Milano Bicocca</institution>
, Monza,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kakadiya, P M" sort="Kakadiya, P M" uniqKey="Kakadiya P" first="P M" last="Kakadiya">P M Kakadiya</name>
<affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Center for Human Genetics, Philipps University Marburg</institution>
, Marburg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bohlander, S" sort="Bohlander, S" uniqKey="Bohlander S" first="S" last="Bohlander">S. Bohlander</name>
<affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Center for Human Genetics, Philipps University Marburg</institution>
, Marburg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ahlmann, M" sort="Ahlmann, M" uniqKey="Ahlmann M" first="M" last="Ahlmann">M. Ahlmann</name>
<affiliation wicri:level="1"><nlm:aff id="aff38"><institution>University Childrens Hospital Muenster, Pediatric Hematology and Oncology</institution>
, Muenster,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Choi, J R" sort="Choi, J R" uniqKey="Choi J" first="J R" last="Choi">J R Choi</name>
<affiliation wicri:level="1"><nlm:aff id="aff39"><institution>Department of Laboratory Medicine, Yonsei University College of Medicine</institution>
, Seoul,<country>Korea</country>
</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gameiro, P" sort="Gameiro, P" uniqKey="Gameiro P" first="P" last="Gameiro">P. Gameiro</name>
<affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Hemato-Oncology Laboratory, UIPM, Portuguese Institute of Oncology of Lisbon</institution>
, Lisbon,<country>Portugal</country>
</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, D S" sort="Lee, D S" uniqKey="Lee D" first="D S" last="Lee">D S Lee</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Laboratory Medicine, Seoul National University College of Medicine</institution>
, Seoul,<country>Korea</country>
</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krauter, J" sort="Krauter, J" uniqKey="Krauter J" first="J" last="Krauter">J. Krauter</name>
<affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Hannover Medical School, Clinic for Hematology, Hemostasis, Oncology and Stem Cell Transplantation</institution>
, Hannover,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cornillet Lefebvre, P" sort="Cornillet Lefebvre, P" uniqKey="Cornillet Lefebvre P" first="P" last="Cornillet-Lefebvre">P. Cornillet-Lefebvre</name>
<affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Laboratoire d'Hématologie, Hôpital Robert-Debré</institution>
, Reims,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Te Kronnie, G" sort="Te Kronnie, G" uniqKey="Te Kronnie G" first="G" last="Te Kronnie">G. Te Kronnie</name>
<affiliation wicri:level="1"><nlm:aff id="aff44"><institution>Department of Women's and Children's Health, University of Padova</institution>
, Padova,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sch Fer, B W" sort="Sch Fer, B W" uniqKey="Sch Fer B" first="B W" last="Sch Fer">B W Sch Fer</name>
<affiliation wicri:level="1"><nlm:aff id="aff45"><institution>University Children's Hospital Zurich, Department of Oncology</institution>
, Zurich,<country>Switzerland</country>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kubetzko, S" sort="Kubetzko, S" uniqKey="Kubetzko S" first="S" last="Kubetzko">S. Kubetzko</name>
<affiliation wicri:level="1"><nlm:aff id="aff45"><institution>University Children's Hospital Zurich, Department of Oncology</institution>
, Zurich,<country>Switzerland</country>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alonso, C N" sort="Alonso, C N" uniqKey="Alonso C" first="C N" last="Alonso">C N Alonso</name>
<affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Hospital Nacional de Pediatría Professor Dr JP Garrahan, Servcio de Hemato-Oncología</institution>
, Buenos Aires,<country>Argentina</country>
</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zur Stadt, U" sort="Zur Stadt, U" uniqKey="Zur Stadt U" first="U" last="Zur Stadt">U. Zur Stadt</name>
<affiliation wicri:level="1"><nlm:aff id="aff47"><institution>Center for Diagnostic, University Medical Center Hamburg Eppendorf</institution>
, Hamburg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sutton, R" sort="Sutton, R" uniqKey="Sutton R" first="R" last="Sutton">R. Sutton</name>
<affiliation wicri:level="1"><nlm:aff id="aff48"><institution>Children's Cancer Institute Australia, University of New South Wales</institution>
, Sydney, New South Wales,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Venn, N C" sort="Venn, N C" uniqKey="Venn N" first="N C" last="Venn">N C Venn</name>
<affiliation wicri:level="1"><nlm:aff id="aff48"><institution>Children's Cancer Institute Australia, University of New South Wales</institution>
, Sydney, New South Wales,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Izraeli, S" sort="Izraeli, S" uniqKey="Izraeli S" first="S" last="Izraeli">S. Izraeli</name>
<affiliation wicri:level="1"><nlm:aff id="aff49"><institution>The Chaim Sheba Medical Center, Department of Pediatric Hemato-Oncology and the Cancer Research Center, and Sackler Medical School Tel Aviv University</institution>
, Tel Aviv,<country>Israel</country>
</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Trakhtenbrot, L" sort="Trakhtenbrot, L" uniqKey="Trakhtenbrot L" first="L" last="Trakhtenbrot">L. Trakhtenbrot</name>
<affiliation wicri:level="1"><nlm:aff id="aff49"><institution>The Chaim Sheba Medical Center, Department of Pediatric Hemato-Oncology and the Cancer Research Center, and Sackler Medical School Tel Aviv University</institution>
, Tel Aviv,<country>Israel</country>
</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Madsen, H O" sort="Madsen, H O" uniqKey="Madsen H" first="H O" last="Madsen">H O Madsen</name>
<affiliation wicri:level="1"><nlm:aff id="aff50"><institution>Department of Clinical Immunology, University Hospital Rigshospitalet</institution>
, Copenhagen,<country>Denmark</country>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Archer, P" sort="Archer, P" uniqKey="Archer P" first="P" last="Archer">P. Archer</name>
<affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Bristol Genetics Laboratory, Pathology Sciences, Southmead Hospital, North Bristol NHS Trust</institution>
, Bristol,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hancock, J" sort="Hancock, J" uniqKey="Hancock J" first="J" last="Hancock">J. Hancock</name>
<affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Bristol Genetics Laboratory, Pathology Sciences, Southmead Hospital, North Bristol NHS Trust</institution>
, Bristol,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cerveira, N" sort="Cerveira, N" uniqKey="Cerveira N" first="N" last="Cerveira">N. Cerveira</name>
<affiliation wicri:level="1"><nlm:aff id="aff52"><institution>Department of Genetics, Portuguese Oncology Institute-Porto, and Biomedical Sciences Institute (ICBAS), University of Porto</institution>
, Porto,<country>Portugal</country>
</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Teixeira, M R" sort="Teixeira, M R" uniqKey="Teixeira M" first="M R" last="Teixeira">M R Teixeira</name>
<affiliation wicri:level="1"><nlm:aff id="aff52"><institution>Department of Genetics, Portuguese Oncology Institute-Porto, and Biomedical Sciences Institute (ICBAS), University of Porto</institution>
, Porto,<country>Portugal</country>
</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lo Nigro, L" sort="Lo Nigro, L" uniqKey="Lo Nigro L" first="L" last="Lo Nigro">L. Lo Nigro</name>
<affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Center of Pediatric Hematology Oncology, University of Catania</institution>
, Catania,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moricke, A" sort="Moricke, A" uniqKey="Moricke A" first="A" last="Möricke">A. Möricke</name>
<affiliation wicri:level="1"><nlm:aff id="aff54"><institution>Department of Pediatrics, University Medical Centre Schleswig-Holstein</institution>
, Kiel,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stanulla, M" sort="Stanulla, M" uniqKey="Stanulla M" first="M" last="Stanulla">M. Stanulla</name>
<affiliation wicri:level="1"><nlm:aff id="aff54"><institution>Department of Pediatrics, University Medical Centre Schleswig-Holstein</institution>
, Kiel,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schrappe, M" sort="Schrappe, M" uniqKey="Schrappe M" first="M" last="Schrappe">M. Schrappe</name>
<affiliation wicri:level="1"><nlm:aff id="aff54"><institution>Department of Pediatrics, University Medical Centre Schleswig-Holstein</institution>
, Kiel,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sedek, L" sort="Sedek, L" uniqKey="Sedek L" first="L" last="Sedék">L. Sedék</name>
<affiliation wicri:level="1"><nlm:aff id="aff55"><institution>Department of Pediatric Hematology and Oncology, Medical University of Silesia</institution>
, Zabrze,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Szczepa Ski, T" sort="Szczepa Ski, T" uniqKey="Szczepa Ski T" first="T" last="Szczepa Ski">T. Szczepa Ski</name>
<affiliation wicri:level="1"><nlm:aff id="aff55"><institution>Department of Pediatric Hematology and Oncology, Medical University of Silesia</institution>
, Zabrze,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zwaan, C M" sort="Zwaan, C M" uniqKey="Zwaan C" first="C M" last="Zwaan">C M Zwaan</name>
<affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Erasmus MC, Sophia Children's Hospital, Department of Pediatric Oncology/Hematology</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Coenen, E A" sort="Coenen, E A" uniqKey="Coenen E" first="E A" last="Coenen">E A Coenen</name>
<affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Erasmus MC, Sophia Children's Hospital, Department of Pediatric Oncology/Hematology</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Den Heuvel Eibrink, M M" sort="Van Den Heuvel Eibrink, M M" uniqKey="Van Den Heuvel Eibrink M" first="M M" last="Van Den Heuvel-Eibrink">M M Van Den Heuvel-Eibrink</name>
<affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Erasmus MC, Sophia Children's Hospital, Department of Pediatric Oncology/Hematology</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Strehl, S" sort="Strehl, S" uniqKey="Strehl S" first="S" last="Strehl">S. Strehl</name>
<affiliation wicri:level="1"><nlm:aff id="aff57"><institution>Children's Cancer Research Institute and Medical University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dworzak, M" sort="Dworzak, M" uniqKey="Dworzak M" first="M" last="Dworzak">M. Dworzak</name>
<affiliation wicri:level="1"><nlm:aff id="aff57"><institution>Children's Cancer Research Institute and Medical University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Panzer Grumayer, R" sort="Panzer Grumayer, R" uniqKey="Panzer Grumayer R" first="R" last="Panzer-Grümayer">R. Panzer-Grümayer</name>
<affiliation wicri:level="1"><nlm:aff id="aff57"><institution>Children's Cancer Research Institute and Medical University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dingermann, T" sort="Dingermann, T" uniqKey="Dingermann T" first="T" last="Dingermann">T. Dingermann</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Biochemistry, Chemistry and Pharmacy, Institute of Pharmaceutical Biology/ZAFES/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University of Frankfurt</institution>
, Frankfurt/Main,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klingebiel, T" sort="Klingebiel, T" uniqKey="Klingebiel T" first="T" last="Klingebiel">T. Klingebiel</name>
<affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Pediatric Hematology and Oncology, University of Frankfurt</institution>
, Frankfurt,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marschalek, R" sort="Marschalek, R" uniqKey="Marschalek R" first="R" last="Marschalek">R. Marschalek</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Biochemistry, Chemistry and Pharmacy, Institute of Pharmaceutical Biology/ZAFES/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University of Frankfurt</institution>
, Frankfurt/Main,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Leukemia</title>
<idno type="ISSN">0887-6924</idno>
<idno type="eISSN">1476-5551</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Chromosomal rearrangements of the human <italic>MLL</italic>
(mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 <italic>MLL</italic>
-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the <italic>MLL</italic>
gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different <italic>MLL</italic>
rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem to be predominantly associated with illegitimate recombinations of the <italic>MLL</italic>
gene (∼90%): <italic>AFF1/AF4</italic>
, <italic>MLLT3/AF9</italic>
, <italic>MLLT1/ENL</italic>
, <italic>MLLT10/AF10</italic>
, <italic>ELL</italic>
, partial tandem duplications (<italic>MLL</italic>
PTDs) and <italic>MLLT4/AF6</italic>
, respectively. The <italic>MLL</italic>
breakpoint distributions for all clinical relevant subtypes (gender, disease type, age at diagnosis, reciprocal, complex and therapy-induced translocations) are presented. Finally, we present the extending network of reciprocal <italic>MLL</italic>
fusions deriving from complex rearrangements.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pui, Ch" uniqKey="Pui C">CH Pui</name>
</author>
<author><name sortKey="Gaynon, Ps" uniqKey="Gaynon P">PS Gaynon</name>
</author>
<author><name sortKey="Boyett, Jm" uniqKey="Boyett J">JM Boyett</name>
</author>
<author><name sortKey="Chessells, Jm" uniqKey="Chessells J">JM Chessells</name>
</author>
<author><name sortKey="Baruchel, A" uniqKey="Baruchel A">A Baruchel</name>
</author>
<author><name sortKey="Kamps, W" uniqKey="Kamps W">W Kamps</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pui, Ch" uniqKey="Pui C">CH Pui</name>
</author>
<author><name sortKey="Chessells, Jm" uniqKey="Chessells J">JM Chessells</name>
</author>
<author><name sortKey="Camitta, B" uniqKey="Camitta B">B Camitta</name>
</author>
<author><name sortKey="Baruchel, A" uniqKey="Baruchel A">A Baruchel</name>
</author>
<author><name sortKey="Biondi, A" uniqKey="Biondi A">A Biondi</name>
</author>
<author><name sortKey="Boyett, Jm" uniqKey="Boyett J">JM Boyett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balgobind, Bv" uniqKey="Balgobind B">BV Balgobind</name>
</author>
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<article-id pub-id-type="doi">10.1038/leu.2013.135</article-id>
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<title-group><article-title>The <italic>MLL</italic>
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<xref ref-type="aff" rid="aff54">54</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schrappe</surname>
<given-names>M</given-names>
</name>
<xref ref-type="aff" rid="aff54">54</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sedék</surname>
<given-names>L</given-names>
</name>
<xref ref-type="aff" rid="aff55">55</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Szczepański</surname>
<given-names>T</given-names>
</name>
<xref ref-type="aff" rid="aff55">55</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zwaan</surname>
<given-names>C M</given-names>
</name>
<xref ref-type="aff" rid="aff56">56</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Coenen</surname>
<given-names>E A</given-names>
</name>
<xref ref-type="aff" rid="aff56">56</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van den Heuvel-Eibrink</surname>
<given-names>M M</given-names>
</name>
<xref ref-type="aff" rid="aff56">56</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Strehl</surname>
<given-names>S</given-names>
</name>
<xref ref-type="aff" rid="aff57">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dworzak</surname>
<given-names>M</given-names>
</name>
<xref ref-type="aff" rid="aff57">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Panzer-Grümayer</surname>
<given-names>R</given-names>
</name>
<xref ref-type="aff" rid="aff57">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dingermann</surname>
<given-names>T</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Klingebiel</surname>
<given-names>T</given-names>
</name>
<xref ref-type="aff" rid="aff26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Marschalek</surname>
<given-names>R</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="caf1">*</xref>
</contrib>
<aff id="aff1"><label>1</label>
<institution>Department of Biochemistry, Chemistry and Pharmacy, Institute of Pharmaceutical Biology/ZAFES/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University of Frankfurt</institution>
, Frankfurt/Main,<country>Germany</country>
</aff>
<aff id="aff2"><label>2</label>
<institution>Charité-Department of Hematology, Oncology and Tumor Immunology</institution>
, Berlin,<country>Germany</country>
</aff>
<aff id="aff3"><label>3</label>
<institution>Department of Laboratory Medicine, School of Medicine, Kyung Hee University</institution>
, Seoul,<country>Korea</country>
</aff>
<aff id="aff4"><label>4</label>
<institution>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro</institution>
, Rio de Janeiro,<country>Brazil</country>
</aff>
<aff id="aff5"><label>5</label>
<institution>Laboratory of Hematology, Biology and Pathology Center, CHRU of Lille; INSERM-U837, Team 3, Cancer Research Institute of Lille</institution>
, Lille,<country>France</country>
</aff>
<aff id="aff6"><label>6</label>
<institution>Biological Hematology, AP-HP Necker-Enfants Malades, Université Paris-Descartes</institution>
, Paris,<country>France</country>
</aff>
<aff id="aff7"><label>7</label>
<institution>Department of Genetics, AP-HP Robert Debré, Paris Diderot University</institution>
, Paris,<country>France</country>
</aff>
<aff id="aff8"><label>8</label>
<institution>CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, Second Faculty of Medicine</institution>
, Prague,<country>Czech Republic</country>
</aff>
<aff id="aff9"><label>9</label>
<institution>Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, Laboratoire d'Histologie, Embryologie et Cytogénétique and INSERM-U1078</institution>
, Brest,<country>France</country>
</aff>
<aff id="aff10"><label>10</label>
<institution>Department of Laboratory Medicine, Inje University College of Medicine</institution>
, Busan,<country>Korea</country>
</aff>
<aff id="aff11"><label>11</label>
<institution>Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center</institution>
, Ekaterinburg,<country>Russia</country>
</aff>
<aff id="aff12"><label>12</label>
<institution>Erasmus MC, Department of Immunology</institution>
, Rotterdam,<country>The Netherlands</country>
</aff>
<aff id="aff13"><label>13</label>
<institution>CHU Purpan, Laboratoire d'Hématologie</institution>
, Toulouse,<country>France</country>
</aff>
<aff id="aff14"><label>14</label>
<institution>Lab. Célula tronco-CEMO-INCA</institution>
, Rio de Janeiro,<country>Brazil</country>
</aff>
<aff id="aff15"><label>15</label>
<institution>Lab. Citogenética-CEMO-INCA</institution>
, Rio de Janeiro,<country>Brazil</country>
</aff>
<aff id="aff16"><label>16</label>
<institution>Belarusian Research Center for Pediatric Oncology, Hematology and Immunology</institution>
, Minsk,<country>Republic of Belarus</country>
</aff>
<aff id="aff17"><label>17</label>
<institution>Departments of Pathology and Laboratory Medicine, Boston Children's Hospital</institution>
, Boston, MA,<country>USA</country>
</aff>
<aff id="aff18"><label>18</label>
<institution>Laboratory of Clinical Genetics, Fimlab Laboratories</institution>
, Tampere,<country>Finland</country>
</aff>
<aff id="aff19"><label>19</label>
<institution>Department of Clinical Chemistry and TYKSLAB, University of Turku and Turku University Central Hospital</institution>
, Turku,<country>Finland</country>
</aff>
<aff id="aff20"><label>20</label>
<institution>Northern Institute for Cancer Research, Newcastle University</institution>
, Newcastle upon Tyne,<country>UK</country>
</aff>
<aff id="aff21"><label>21</label>
<institution>Northern Institute for Cancer Research, Newcastle University and the Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust</institution>
, Newcastle upon Tyne,<country>UK</country>
</aff>
<aff id="aff22"><label>22</label>
<institution>Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</institution>
, Hong Kong,<country>China</country>
</aff>
<aff id="aff23"><label>23</label>
<institution>Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc</institution>
, Olomouc,<country>Czech Republic</country>
</aff>
<aff id="aff24"><label>24</label>
<institution>Department of Pediatric Hematology and Oncology, University Childrens' Hospital and Medical School of Comenius University</institution>
, Bratislava,<country>Slovakia</country>
</aff>
<aff id="aff25"><label>25</label>
<institution>GENyO, Centre for Genomics and Oncological Research: Pfizer, Universidad de Granada, Junta de Andalucia, Granada and Josep Carreras Leukemia Research Institute/Cell Therapy Program University of Barcelona</institution>
, Barcelona,<country>Spain</country>
</aff>
<aff id="aff26"><label>26</label>
<institution>Pediatric Hematology and Oncology, University of Frankfurt</institution>
, Frankfurt,<country>Germany</country>
</aff>
<aff id="aff27"><label>27</label>
<institution>Charité-Department of Pediatric Oncology and Hematology</institution>
, Berlin,<country>Germany</country>
</aff>
<aff id="aff28"><label>28</label>
<institution>Department of Hematology, Centre Hospitalier Universitaire</institution>
, Nantes,<country>France</country>
</aff>
<aff id="aff29"><label>29</label>
<institution>CHU Montpellier, Institute for Research in Biotherapy, Laboratory of Hematology, Hôpital Saint-Eloi and NSERM-U847</institution>
, Montpellier,<country>France</country>
</aff>
<aff id="aff30"><label>30</label>
<institution>Laboratoire d'Hématologie, CHU de Bordeaux</institution>
, Bordeaux,<country>France</country>
</aff>
<aff id="aff31"><label>31</label>
<institution>Service de Cytogénétique et de Biologie Cellulaire, CHU de Rennes, Hôpital Pontchaillou</institution>
, Rennes,<country>France</country>
</aff>
<aff id="aff32"><label>32</label>
<institution>Biological Hematology, AP-HP A Trousseau, Pierre et Marie Curie University</institution>
, Paris,<country>France</country>
</aff>
<aff id="aff33"><label>33</label>
<institution>INSERM-U823, Oncogenic Pathways in the Haematological Malignancies, Institut Albert Bonniot</institution>
, Grenoble,<country>France</country>
</aff>
<aff id="aff34"><label>34</label>
<institution>Laboratoire d'Hématologie, AP-HP Saint-Louis, Paris Diderot University</institution>
, Paris,<country>France</country>
</aff>
<aff id="aff35"><label>35</label>
<institution>Service d'Hématologie Immunologie Cytogénétique, Centre Hospitalier de Valenciennes</institution>
, Valenciennes,<country>France</country>
</aff>
<aff id="aff36"><label>36</label>
<institution>Centro Ricerca Tettamanti, Clinica Pediatrica Univ. Milano Bicocca</institution>
, Monza,<country>Italy</country>
</aff>
<aff id="aff37"><label>37</label>
<institution>Center for Human Genetics, Philipps University Marburg</institution>
, Marburg,<country>Germany</country>
</aff>
<aff id="aff38"><label>38</label>
<institution>University Childrens Hospital Muenster, Pediatric Hematology and Oncology</institution>
, Muenster,<country>Germany</country>
</aff>
<aff id="aff39"><label>39</label>
<institution>Department of Laboratory Medicine, Yonsei University College of Medicine</institution>
, Seoul,<country>Korea</country>
</aff>
<aff id="aff40"><label>40</label>
<institution>Hemato-Oncology Laboratory, UIPM, Portuguese Institute of Oncology of Lisbon</institution>
, Lisbon,<country>Portugal</country>
</aff>
<aff id="aff41"><label>41</label>
<institution>Department of Laboratory Medicine, Seoul National University College of Medicine</institution>
, Seoul,<country>Korea</country>
</aff>
<aff id="aff42"><label>42</label>
<institution>Hannover Medical School, Clinic for Hematology, Hemostasis, Oncology and Stem Cell Transplantation</institution>
, Hannover,<country>Germany</country>
</aff>
<aff id="aff43"><label>43</label>
<institution>Laboratoire d'Hématologie, Hôpital Robert-Debré</institution>
, Reims,<country>France</country>
</aff>
<aff id="aff44"><label>44</label>
<institution>Department of Women's and Children's Health, University of Padova</institution>
, Padova,<country>Italy</country>
</aff>
<aff id="aff45"><label>45</label>
<institution>University Children's Hospital Zurich, Department of Oncology</institution>
, Zurich,<country>Switzerland</country>
</aff>
<aff id="aff46"><label>46</label>
<institution>Hospital Nacional de Pediatría Professor Dr JP Garrahan, Servcio de Hemato-Oncología</institution>
, Buenos Aires,<country>Argentina</country>
</aff>
<aff id="aff47"><label>47</label>
<institution>Center for Diagnostic, University Medical Center Hamburg Eppendorf</institution>
, Hamburg,<country>Germany</country>
</aff>
<aff id="aff48"><label>48</label>
<institution>Children's Cancer Institute Australia, University of New South Wales</institution>
, Sydney, New South Wales,<country>Australia</country>
</aff>
<aff id="aff49"><label>49</label>
<institution>The Chaim Sheba Medical Center, Department of Pediatric Hemato-Oncology and the Cancer Research Center, and Sackler Medical School Tel Aviv University</institution>
, Tel Aviv,<country>Israel</country>
</aff>
<aff id="aff50"><label>50</label>
<institution>Department of Clinical Immunology, University Hospital Rigshospitalet</institution>
, Copenhagen,<country>Denmark</country>
</aff>
<aff id="aff51"><label>51</label>
<institution>Bristol Genetics Laboratory, Pathology Sciences, Southmead Hospital, North Bristol NHS Trust</institution>
, Bristol,<country>UK</country>
</aff>
<aff id="aff52"><label>52</label>
<institution>Department of Genetics, Portuguese Oncology Institute-Porto, and Biomedical Sciences Institute (ICBAS), University of Porto</institution>
, Porto,<country>Portugal</country>
</aff>
<aff id="aff53"><label>53</label>
<institution>Center of Pediatric Hematology Oncology, University of Catania</institution>
, Catania,<country>Italy</country>
</aff>
<aff id="aff54"><label>54</label>
<institution>Department of Pediatrics, University Medical Centre Schleswig-Holstein</institution>
, Kiel,<country>Germany</country>
</aff>
<aff id="aff55"><label>55</label>
<institution>Department of Pediatric Hematology and Oncology, Medical University of Silesia</institution>
, Zabrze,<country>Poland</country>
</aff>
<aff id="aff56"><label>56</label>
<institution>Erasmus MC, Sophia Children's Hospital, Department of Pediatric Oncology/Hematology</institution>
, Rotterdam,<country>The Netherlands</country>
</aff>
<aff id="aff57"><label>57</label>
<institution>Children's Cancer Research Institute and Medical University of Vienna</institution>
, Vienna,<country>Austria</country>
</aff>
</contrib-group>
<author-notes><corresp id="caf1"><label>*</label>
<institution>Department of Biochemistry, Chemistry and Pharmacy, Institute of Pharmaceutical Biology/ZAFES/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University of Frankfurt</institution>
, Marie-Curie Strasse 9, Frankfurt/Main 60439, <country>Germany</country>
. E-mail: <email>Rolf.Marschalek@em.uni-frankfurt.de</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>11</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epreprint"><day>30</day>
<month>04</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>17</day>
<month>05</month>
<year>2013</year>
</pub-date>
<volume>27</volume>
<issue>11</issue>
<fpage>2165</fpage>
<lpage>2176</lpage>
<history><date date-type="received"><day>25</day>
<month>03</month>
<year>2013</year>
</date>
<date date-type="rev-recd"><day>23</day>
<month>04</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>25</day>
<month>04</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2013 Macmillan Publishers Limited</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder>Macmillan Publishers Limited</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/</license-p>
</license>
</permissions>
<abstract><p>Chromosomal rearrangements of the human <italic>MLL</italic>
(mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 <italic>MLL</italic>
-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the <italic>MLL</italic>
gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different <italic>MLL</italic>
rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem to be predominantly associated with illegitimate recombinations of the <italic>MLL</italic>
gene (∼90%): <italic>AFF1/AF4</italic>
, <italic>MLLT3/AF9</italic>
, <italic>MLLT1/ENL</italic>
, <italic>MLLT10/AF10</italic>
, <italic>ELL</italic>
, partial tandem duplications (<italic>MLL</italic>
PTDs) and <italic>MLLT4/AF6</italic>
, respectively. The <italic>MLL</italic>
breakpoint distributions for all clinical relevant subtypes (gender, disease type, age at diagnosis, reciprocal, complex and therapy-induced translocations) are presented. Finally, we present the extending network of reciprocal <italic>MLL</italic>
fusions deriving from complex rearrangements.</p>
</abstract>
<kwd-group><kwd><italic>MLL</italic>
</kwd>
<kwd>chromosomal translocations</kwd>
<kwd>translocation partner genes</kwd>
<kwd>acute leukemia</kwd>
<kwd>ALL</kwd>
<kwd>AML</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="fig1"><label>Figure 1</label>
<caption><p>Age distribution of investigated patients. The age distribution of all analyzed patients (<italic>n</italic>
=1690) is summarized. (Upper part) Diagram displaying ALL and AML patients. Age at diagnosis was for infants (0–1 year), pediatric (1–18 years) and adult patients (>18 years). The number of ALL, AML and other patients is listed below. We also added the information about TIL patients, the number of complex <italic>MLL</italic>
rearrangements (CL) and specified the ‘Non-ALL' and ‘Non-AML' patients (MLL, myelodysplastic syndrome (MDS), primary myelofibrosis (PMF) and unknown) in more detail for each age group. The precise number of patient cases summarized on the right.</p>
</caption>
<graphic xlink:href="leu2013135f1"></graphic>
</fig>
<fig id="fig2"><label>Figure 2</label>
<caption><p>Classification of patients according to age classes and disease type. (Top) Frequency of most frequent TPGs in the investigated patient cohort of MLL-rearranged acute leukemia patients (<italic>n=</italic>
1590). This patient cohort was divided into ALL (left) and AML patients (right). Gene names are written in black, and percentages are indicated as white numbers. Thirty-three patients could not be classified into the ALL or the AML disease types, respectively. (Middle) TPG frequencies for the infant, pediatric and adult patient group. (Bottom) Subdivision of all three age groups into ALL and AML patients. Negative numbers confer again to the number of patients who were neither classified to the ‘ALL' nor to the ‘AML' subgroup.</p>
</caption>
<graphic xlink:href="leu2013135f2"></graphic>
</fig>
<fig id="fig3"><label>Figure 3</label>
<caption><p>World distribution of patients. (Top) Worldmap grossly dividing the investigated patients into three distinct subgroups: American, European and Asian countries. The number of investigated patients is shown and the contribution of individual countries is given in patient numbers. Each country is indicated by its international country code. (Below) Information about the patient cohort. Mean age, age range and the amount of infants (I), pediatric (P) and adult patients (A) is indicated. In addition, we added the amount of therapy-induced malignancies in number and percentage. The breakpoint distribution for each subgroup within MLL exon 9/intron 9, MLL exon 10/intron 10 and MLL exon 11/intron 11 is displayed. Red mark in <italic>MLL</italic>
intron 11: fragile site within <italic>MLL</italic>
that is sensible to exogenous drug exposure.</p>
</caption>
<graphic xlink:href="leu2013135f3"></graphic>
</fig>
<fig id="fig4"><label>Figure 4</label>
<caption><p>General recombination mechanism and associated TPGs. (Top) Genes are categorized either by reciprocal chromosomal translocation (rCTL; <italic>n</italic>
=51), spliced fusion (Spl; <italic>n</italic>
=3), inversions at 11p/q (Inv; <italic>n</italic>
=9), insertions (Ins1 and Ins2; <italic>n</italic>
=12) or 11q deletions (Del; <italic>n</italic>
=4). (Bottom) All identified recombination events, arranged according to the number of DNA double-strand breaks (DSBs) necessary to explain the recombination event. Green: Chromosome 11; red and orange: partner chromosomes involved in the recombination process. Green vertical bars: <italic>MLL</italic>
; red, orange, blue and pink vertical bars: partner genes involved in recombination events; derivative 11 chromosomes is always depicted by ‘Der'. Black and white horizontal lines: recombination sites on wild-type and derivative chromosomes. rCTL: reciprocal chromosomal translocation; Del/Inv: deletion/inversion; 3 W-CTL: three-way chromosomal translocation; CTL+Δ: chromosomal translocation including deletion(s); Ins1: chromosomal fragment including portions of the <italic>MLL</italic>
gene is inserted into a partner chromosome; Ins2: chromosomal fragment including portions of a partner gene is inserted into the <italic>MLL</italic>
gene; cCTL: complex chromosomal translocations, for example, by chromothripsis.</p>
</caption>
<graphic xlink:href="leu2013135f4"></graphic>
</fig>
<fig id="fig5"><label>Figure 5</label>
<caption><p>Common pathways of the most frequent MLL fusions. The four most frequent MLL fusions, MLL-ENL, MLL-AF9, MLL-AF10 and AF4-MLL, are either interacting directly with the AF4 complex or are mimicking the AF4 complex in case of AF4-MLL. The crucial components within the AF4 complex are the P-TEFb kinase and the H3K79 HMT DOT1L protein. Hyperactive AF4 or AF4-MLL is strongly enhances the transcriptional processes. In addition, changes in the steady-state AF4 complex stability is causing extended H3K79me2/3 signatures. Future inhibitory strategies are indicated in red.</p>
</caption>
<graphic xlink:href="leu2013135f5"></graphic>
</fig>
<table-wrap id="tbl1"><label>Table 1</label>
<caption><title>Overview about all investigated TPGs</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
</colgroup>
<thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><italic>Direct TPG</italic>
</th>
<th colspan="3" align="center" valign="top" char="." charoff="50"><italic>Infant</italic>
<hr></hr>
</th>
<th colspan="3" align="center" valign="top" char="." charoff="50"><italic>Pediatric</italic>
<hr></hr>
</th>
<th colspan="3" align="center" valign="top" char="." charoff="50"><italic>Adult</italic>
<hr></hr>
</th>
<th align="center" valign="top" char="." charoff="50"><italic>Total</italic>
</th>
</tr>
<tr><th align="left" valign="top" charoff="50"> </th>
<th align="char" valign="top" char="." charoff="50"><italic>ALL</italic>
</th>
<th align="char" valign="top" char="." charoff="50"><italic>AML</italic>
</th>
<th align="char" valign="top" char="." charoff="50"><italic>Other</italic>
</th>
<th align="char" valign="top" char="." charoff="50"><italic>ALL</italic>
</th>
<th align="char" valign="top" char="." charoff="50"><italic>AML</italic>
</th>
<th align="char" valign="top" char="." charoff="50"><italic>Other</italic>
</th>
<th align="char" valign="top" char="." charoff="50"><italic>ALL</italic>
</th>
<th align="char" valign="top" char="." charoff="50"><italic>AML</italic>
</th>
<th align="char" valign="top" char="." charoff="50"><italic>Other</italic>
</th>
<th align="char" valign="top" char="." charoff="50"> </th>
</tr>
</thead>
<tbody valign="top"><tr><td align="left" valign="top" charoff="50"><italic>AFF1/AF4</italic>
</td>
<td align="char" valign="top" char="." charoff="50">216</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">4</td>
<td align="char" valign="top" char="." charoff="50">97</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">274</td>
<td align="char" valign="top" char="." charoff="50">3</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">600</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>MLLT3/AF9</italic>
</td>
<td align="char" valign="top" char="." charoff="50">73</td>
<td align="char" valign="top" char="." charoff="50">23</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">37</td>
<td align="char" valign="top" char="." charoff="50">73</td>
<td align="char" valign="top" char="." charoff="50">3</td>
<td align="char" valign="top" char="." charoff="50">6</td>
<td align="char" valign="top" char="." charoff="50">71</td>
<td align="char" valign="top" char="." charoff="50">3</td>
<td align="char" valign="top" char="." charoff="50">291</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>MLLT1/ENL</italic>
</td>
<td align="char" valign="top" char="." charoff="50">96</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">40</td>
<td align="char" valign="top" char="." charoff="50">10</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">37</td>
<td align="char" valign="top" char="." charoff="50">12</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">199</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>MLLT10/AF10</italic>
</td>
<td align="char" valign="top" char="." charoff="50">22</td>
<td align="char" valign="top" char="." charoff="50">28</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">4</td>
<td align="char" valign="top" char="." charoff="50">40</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">20</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">120</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>ELL</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">18</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">19</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">29</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">68</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>PTD</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">64</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">68</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>MLLT4/AF6</italic>
</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">3</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">5</td>
<td align="char" valign="top" char="." charoff="50">19</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">6</td>
<td align="char" valign="top" char="." charoff="50">33</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">67</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>EPS15</italic>
</td>
<td align="char" valign="top" char="." charoff="50">12</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">4</td>
<td align="char" valign="top" char="." charoff="50">3</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">4</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">26</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>MLLT11/AF1Q</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">7</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">4</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">13</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>SEPT9</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">5</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">5</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">12</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>SEPT6</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">3</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">6</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">11</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>MLLT6/AF17</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">7</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">10</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>NA</italic>
</td>
<td align="char" valign="top" char="." charoff="50">9</td>
<td align="char" valign="top" char="." charoff="50">3</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">3</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">19</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>AFF3/LAF4</italic>
</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">3</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">5</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>TET1</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">5</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>PICALM</italic>
</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">4</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>ABI1</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">3</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>CASC5</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">3</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>MYO1F</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">3</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">3</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>SEPT5</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">3</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>ACTN4</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>FLNA</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
</tr>
<tr><td align="justify" valign="top" charoff="50"><italic>FOXO3</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>CEP170B</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>MAML2</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>SEPT11</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>TNRC18</italic>
</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>ABI2</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>ACACA</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>AFF4/AF5</italic>
</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>AKAP13</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>AP2A2</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">–</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>ARHGEF12</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">–</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">–</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>ARHGEF17</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>BCL9L</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>BUD13</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">——</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>C2CD3</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>CASP8AP2</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>CBL</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>CEP164</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>CREBBP</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>DCP1A</italic>
</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>DCPS</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>FNBP1</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>GAS7</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>GMPS</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>KIAA1524</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>LAMC3</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>LOC100131626</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>BTBD18</italic>
</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>ME2</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>MYH11</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>NEBL</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>NRIP3</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>PDS5A</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>PRPF19</italic>
</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>RUNDC3B</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>EEFSEC/SELB</italic>
</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>SEPT2</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>SMAP1</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>TOP3A</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>VAV1</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>1p13.1</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>1p32 (EPS15)</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>9p13.3</italic>
</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>9p22 (MLLT3/AF9)</italic>
</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>11q23</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">2</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>11q23.3</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>11q24</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>21q22</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>Xq26.3 (CT45A2)</italic>
</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">—</td>
<td align="char" valign="top" char="." charoff="50">1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50">Sum</td>
<td align="char" valign="top" char="." charoff="50">440</td>
<td align="char" valign="top" char="." charoff="50">105</td>
<td align="char" valign="top" char="." charoff="50">13</td>
<td align="char" valign="top" char="." charoff="50">205</td>
<td align="char" valign="top" char="." charoff="50">202</td>
<td align="char" valign="top" char="." charoff="50">9</td>
<td align="char" valign="top" char="." charoff="50">333</td>
<td align="char" valign="top" char="." charoff="50">272</td>
<td align="char" valign="top" char="." charoff="50">11</td>
<td align="char" valign="top" char="." charoff="50">1590</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t1-fn1"><p>Abbreviations: ALL, acute lymphocytic leukemia; AML, acute myeloid leukemia; DCAL, Diagnostic Center of Acute Leukemia.</p>
</fn>
<fn id="t1-fn2"><p>All fusion genes that have been analyzed at the DCAL and their distribution between infant, pediatric and adult leukemia patients are shown. Total numbers are given for each patient group separate in ALL, AML and other diseases. The most frequent fusion partner genes were separated from the gene that has been isolated less frequently.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
<affiliations><list><country><li>Allemagne</li>
<li>Argentine</li>
<li>Australie</li>
<li>Autriche</li>
<li>Brésil</li>
<li>Corée du Sud</li>
<li>Danemark</li>
<li>Espagne</li>
<li>Finlande</li>
<li>France</li>
<li>Israël</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Portugal</li>
<li>Royaume-Uni</li>
<li>Russie</li>
<li>République populaire de Chine</li>
<li>République tchèque</li>
<li>Slovaquie</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
</list>
<tree><noCountry><name sortKey="Aleinikova, O" sort="Aleinikova, O" uniqKey="Aleinikova O" first="O" last="Aleinikova">O. Aleinikova</name>
<name sortKey="Kustanovich, A" sort="Kustanovich, A" uniqKey="Kustanovich A" first="A" last="Kustanovich">A. Kustanovich</name>
</noCountry>
<country name="Allemagne"><noRegion><name sortKey="Meyer, C" sort="Meyer, C" uniqKey="Meyer C" first="C" last="Meyer">C. Meyer</name>
</noRegion>
<name sortKey="Ahlmann, M" sort="Ahlmann, M" uniqKey="Ahlmann M" first="M" last="Ahlmann">M. Ahlmann</name>
<name sortKey="Bohlander, S" sort="Bohlander, S" uniqKey="Bohlander S" first="S" last="Bohlander">S. Bohlander</name>
<name sortKey="Burmeister, T" sort="Burmeister, T" uniqKey="Burmeister T" first="T" last="Burmeister">T. Burmeister</name>
<name sortKey="Dingermann, T" sort="Dingermann, T" uniqKey="Dingermann T" first="T" last="Dingermann">T. Dingermann</name>
<name sortKey="Eckert, C" sort="Eckert, C" uniqKey="Eckert C" first="C" last="Eckert">C. Eckert</name>
<name sortKey="Groger, D" sort="Groger, D" uniqKey="Groger D" first="D" last="Gröger">D. Gröger</name>
<name sortKey="Hofmann, J" sort="Hofmann, J" uniqKey="Hofmann J" first="J" last="Hofmann">J. Hofmann</name>
<name sortKey="Kakadiya, P M" sort="Kakadiya, P M" uniqKey="Kakadiya P" first="P M" last="Kakadiya">P M Kakadiya</name>
<name sortKey="Klingebiel, T" sort="Klingebiel, T" uniqKey="Klingebiel T" first="T" last="Klingebiel">T. Klingebiel</name>
<name sortKey="Krauter, J" sort="Krauter, J" uniqKey="Krauter J" first="J" last="Krauter">J. Krauter</name>
<name sortKey="Marschalek, R" sort="Marschalek, R" uniqKey="Marschalek R" first="R" last="Marschalek">R. Marschalek</name>
<name sortKey="Moricke, A" sort="Moricke, A" uniqKey="Moricke A" first="A" last="Möricke">A. Möricke</name>
<name sortKey="Schrappe, M" sort="Schrappe, M" uniqKey="Schrappe M" first="M" last="Schrappe">M. Schrappe</name>
<name sortKey="Stanulla, M" sort="Stanulla, M" uniqKey="Stanulla M" first="M" last="Stanulla">M. Stanulla</name>
<name sortKey="Wehner, S" sort="Wehner, S" uniqKey="Wehner S" first="S" last="Wehner">S. Wehner</name>
<name sortKey="Zur Stadt, U" sort="Zur Stadt, U" uniqKey="Zur Stadt U" first="U" last="Zur Stadt">U. Zur Stadt</name>
</country>
<country name="Corée du Sud"><noRegion><name sortKey="Park, T S" sort="Park, T S" uniqKey="Park T" first="T S" last="Park">T S Park</name>
</noRegion>
<name sortKey="Choi, J R" sort="Choi, J R" uniqKey="Choi J" first="J R" last="Choi">J R Choi</name>
<name sortKey="Lee, D S" sort="Lee, D S" uniqKey="Lee D" first="D S" last="Lee">D S Lee</name>
<name sortKey="Oh, S H" sort="Oh, S H" uniqKey="Oh S" first="S H" last="Oh">S H Oh</name>
</country>
<country name="Brésil"><noRegion><name sortKey="Emerenciano, M" sort="Emerenciano, M" uniqKey="Emerenciano M" first="M" last="Emerenciano">M. Emerenciano</name>
</noRegion>
<name sortKey="Binato, R" sort="Binato, R" uniqKey="Binato R" first="R" last="Binato">R. Binato</name>
<name sortKey="Pombo De Oliveira, M" sort="Pombo De Oliveira, M" uniqKey="Pombo De Oliveira M" first="M" last="Pombo De Oliveira">M. Pombo De Oliveira</name>
<name sortKey="Silva, M L M" sort="Silva, M L M" uniqKey="Silva M" first="M L M" last="Silva">M L M. Silva</name>
</country>
<country name="France"><noRegion><name sortKey="Renneville, A" sort="Renneville, A" uniqKey="Renneville A" first="A" last="Renneville">A. Renneville</name>
</noRegion>
<name sortKey="Ballerini, P" sort="Ballerini, P" uniqKey="Ballerini P" first="P" last="Ballerini">P. Ballerini</name>
<name sortKey="Callanan, M B" sort="Callanan, M B" uniqKey="Callanan M" first="M B" last="Callanan">M B Callanan</name>
<name sortKey="Cave, H" sort="Cave, H" uniqKey="Cave H" first="H" last="Cavé">H. Cavé</name>
<name sortKey="Cayuela, J M" sort="Cayuela, J M" uniqKey="Cayuela J" first="J M" last="Cayuela">J M Cayuela</name>
<name sortKey="Clappier, E" sort="Clappier, E" uniqKey="Clappier E" first="E" last="Clappier">E. Clappier</name>
<name sortKey="Cornillet Lefebvre, P" sort="Cornillet Lefebvre, P" uniqKey="Cornillet Lefebvre P" first="P" last="Cornillet-Lefebvre">P. Cornillet-Lefebvre</name>
<name sortKey="De Braekeleer, E" sort="De Braekeleer, E" uniqKey="De Braekeleer E" first="E" last="De Braekeleer">E. De Braekeleer</name>
<name sortKey="De Braekeleer, M" sort="De Braekeleer, M" uniqKey="De Braekeleer M" first="M" last="De Braekeleer">M. De Braekeleer</name>
<name sortKey="Delabesse, E" sort="Delabesse, E" uniqKey="Delabesse E" first="E" last="Delabesse">E. Delabesse</name>
<name sortKey="Henry, C" sort="Henry, C" uniqKey="Henry C" first="C" last="Henry">C. Henry</name>
<name sortKey="Herbaux, C" sort="Herbaux, C" uniqKey="Herbaux C" first="C" last="Herbaux">C. Herbaux</name>
<name sortKey="Lapillone, H" sort="Lapillone, H" uniqKey="Lapillone H" first="H" last="Lapillone">H. Lapillone</name>
<name sortKey="Launay, E" sort="Launay, E" uniqKey="Launay E" first="E" last="Launay">E. Launay</name>
<name sortKey="Lippert, E" sort="Lippert, E" uniqKey="Lippert E" first="E" last="Lippert">E. Lippert</name>
<name sortKey="Macintyre, E" sort="Macintyre, E" uniqKey="Macintyre E" first="E" last="Macintyre">E. Macintyre</name>
<name sortKey="Mass Malo, K" sort="Mass Malo, K" uniqKey="Mass Malo K" first="K" last="Mass-Malo">K. Mass-Malo</name>
<name sortKey="Talmant, P" sort="Talmant, P" uniqKey="Talmant P" first="P" last="Talmant">P. Talmant</name>
<name sortKey="Tondeur, S" sort="Tondeur, S" uniqKey="Tondeur S" first="S" last="Tondeur">S. Tondeur</name>
<name sortKey="Villarese, P" sort="Villarese, P" uniqKey="Villarese P" first="P" last="Villarese">P. Villarese</name>
</country>
<country name="République tchèque"><noRegion><name sortKey="Zuna, J" sort="Zuna, J" uniqKey="Zuna J" first="J" last="Zuna">J. Zuna</name>
</noRegion>
<name sortKey="Jarosova, M" sort="Jarosova, M" uniqKey="Jarosova M" first="M" last="Jarosova">M. Jarosova</name>
<name sortKey="Trka, J" sort="Trka, J" uniqKey="Trka J" first="J" last="Trka">J. Trka</name>
</country>
<country name="Russie"><noRegion><name sortKey="Tsaur, G" sort="Tsaur, G" uniqKey="Tsaur G" first="G" last="Tsaur">G. Tsaur</name>
</noRegion>
<name sortKey="Fechina, L" sort="Fechina, L" uniqKey="Fechina L" first="L" last="Fechina">L. Fechina</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Van Der Velden, V H J" sort="Van Der Velden, V H J" uniqKey="Van Der Velden V" first="V H J" last="Van Der Velden">V H J. Van Der Velden</name>
</noRegion>
<name sortKey="Coenen, E A" sort="Coenen, E A" uniqKey="Coenen E" first="E A" last="Coenen">E A Coenen</name>
<name sortKey="Van Den Heuvel Eibrink, M M" sort="Van Den Heuvel Eibrink, M M" uniqKey="Van Den Heuvel Eibrink M" first="M M" last="Van Den Heuvel-Eibrink">M M Van Den Heuvel-Eibrink</name>
<name sortKey="Van Dongen, J J M" sort="Van Dongen, J J M" uniqKey="Van Dongen J" first="J J M" last="Van Dongen">J J M. Van Dongen</name>
<name sortKey="Zwaan, C M" sort="Zwaan, C M" uniqKey="Zwaan C" first="C M" last="Zwaan">C M Zwaan</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Harris, M H" sort="Harris, M H" uniqKey="Harris M" first="M H" last="Harris">M H Harris</name>
</noRegion>
</country>
<country name="Finlande"><noRegion><name sortKey="Lund Aho, T" sort="Lund Aho, T" uniqKey="Lund Aho T" first="T" last="Lund-Aho">T. Lund-Aho</name>
</noRegion>
<name sortKey="Juvonen, V" sort="Juvonen, V" uniqKey="Juvonen V" first="V" last="Juvonen">V. Juvonen</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Heidenreich, O" sort="Heidenreich, O" uniqKey="Heidenreich O" first="O" last="Heidenreich">O. Heidenreich</name>
</noRegion>
<name sortKey="Archer, P" sort="Archer, P" uniqKey="Archer P" first="P" last="Archer">P. Archer</name>
<name sortKey="Hancock, J" sort="Hancock, J" uniqKey="Hancock J" first="J" last="Hancock">J. Hancock</name>
<name sortKey="Vormoor, J" sort="Vormoor, J" uniqKey="Vormoor J" first="J" last="Vormoor">J. Vormoor</name>
</country>
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