A certified plasmid reference material for the standardisation of BCR–ABL1 mRNA quantification by real-time quantitative PCR
Identifieur interne : 001774 ( Pmc/Checkpoint ); précédent : 001773; suivant : 001775A certified plasmid reference material for the standardisation of BCR–ABL1 mRNA quantification by real-time quantitative PCR
Auteurs : H. White [Royaume-Uni] ; L. Deprez [Belgique] ; P. Corbisier [Belgique] ; V. Hall [Royaume-Uni] ; F. Lin [Royaume-Uni] ; S. Mazoua [Belgique] ; S. Trapmann [Belgique] ; A. Aggerholm [Danemark] ; H. Andrikovics [Hongrie] ; S. Akiki [Royaume-Uni] ; G. Barbany [Suède] ; N. Boeckx [Belgique] ; A. Bench [Royaume-Uni] ; M. Catherwood [Royaume-Uni] ; J-M Cayuela [France] ; S. Chudleigh [Royaume-Uni] ; T. Clench [Royaume-Uni] ; D. Colomer [Espagne] ; F. Daraio [Italie] ; S. Dulucq [France] ; J. Farrugia [Royaume-Uni] ; L. Fletcher [Australie] ; L. Foroni [Royaume-Uni] ; R. Ganderton [Royaume-Uni] ; G. Gerrard [Royaume-Uni] ; E. Gineikien [Lituanie] ; S. Hayette [France] ; H. El Housni [Belgique] ; B. Izzo [Italie] ; M. Jansson [Suède] ; P. Johnels [Suède] ; T. Jurcek [République tchèque] ; V. Kairisto [Finlande] ; A. Kizilors [Royaume-Uni] ; D-W Kim [Corée du Sud] ; T. Lange [Allemagne] ; T. Lion [Autriche] ; K M Polakova [République tchèque] ; G. Martinelli [Italie] ; S. Mccarron [Irlande (pays)] ; P A Merle [Pays-Bas] ; B. Milner [Royaume-Uni] ; G. Mitterbauer-Hohendanner [Autriche] ; M. Nagar [Israël] ; G. Nickless [Royaume-Uni] ; J. Nomdedéu [Espagne] ; D A Nymoen [Norvège] ; E O Leibundgut [Suisse] ; U. Ozbek [Turquie] ; T. Paji [Slovénie] ; H. Pfeifer [Allemagne] ; C. Preudhomme [France] ; K. Raudsepp [Estonie] ; G. Romeo [Australie] ; T. Sacha [Pologne] ; R. Talmaci [Roumanie] ; T. Touloumenidou [Grèce] ; V H J. Van Der Velden [Pays-Bas] ; P. Waits [Royaume-Uni] ; L. Wang [Royaume-Uni] ; E. Wilkinson [Royaume-Uni] ; G. Wilson [Royaume-Uni] ; D. Wren [Royaume-Uni] ; R. Zadro [Croatie] ; J. Ziermann [Allemagne] ; K. Zoi [Grèce] ; M C Müller [Allemagne] ; A. Hochhaus [Allemagne] ; H. Schimmel [Belgique] ; N C P. Cross [Royaume-Uni] ; H. Emons [Belgique]Source :
- Leukemia [ 0887-6924 ] ; 2014.
Abstract
Serial quantification of
Url:
DOI: 10.1038/leu.2014.217
PubMed: 25036192
PubMed Central: 4320294
Affiliations:
- Allemagne, Australie, Autriche, Belgique, Corée du Sud, Croatie, Danemark, Espagne, Estonie, Finlande, France, Grèce, Hongrie, Irlande (pays), Israël, Italie, Lituanie, Norvège, Pays-Bas, Pologne, Roumanie, Royaume-Uni, République tchèque, Slovénie, Suisse, Suède, Turquie
- Angleterre, Aquitaine, Attique (région), Bade-Wurtemberg, Bohême centrale, Canton de Berne, Catalogne, District de Darmstadt, District de Karlsruhe, District de Leipzig, East Middle Sweden, Finlande occidentale, Grand Londres, Hauts-de-France, Hesse (Land), Hollande-Méridionale, Hollande-Septentrionale, Moravie, Nord-Pas-de-Calais, Nouvelle-Aquitaine, Piémont, Région capitale de Séoul, Région de Bruxelles-Capitale, Saxe (Land), Svealand, Vienne (Autriche), Østlandet
- Amsterdam, Athènes, Barcelone, Berne, Bordeaux, Brno, Bruxelles, Francfort-sur-le-Main, Leipzig, Lille, Londres, Mannheim, Oslo, Prague, Rotterdam, Séoul, Turin, Turku, Uppsala, Vienne (Autriche)
- Université d'Uppsala
Links toward previous steps (curation, corpus...)
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PMC:4320294Le document en format XML
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White</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>, Salisbury,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Faculty of Medicine, University of Southampton</institution>, Southampton,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deprez, L" sort="Deprez, L" uniqKey="Deprez L" first="L" last="Deprez">L. Deprez</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>, Geel,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Corbisier, P" sort="Corbisier, P" uniqKey="Corbisier P" first="P" last="Corbisier">P. Corbisier</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>, Geel,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hall, V" sort="Hall, V" uniqKey="Hall V" first="V" last="Hall">V. Hall</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>, Salisbury,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, F" sort="Lin, F" uniqKey="Lin F" first="F" last="Lin">F. Lin</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>, Salisbury,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Faculty of Medicine, University of Southampton</institution>, Southampton,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mazoua, S" sort="Mazoua, S" uniqKey="Mazoua S" first="S" last="Mazoua">S. Mazoua</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>, Geel,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Trapmann, S" sort="Trapmann, S" uniqKey="Trapmann S" first="S" last="Trapmann">S. Trapmann</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>, Geel,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aggerholm, A" sort="Aggerholm, A" uniqKey="Aggerholm A" first="A" last="Aggerholm">A. Aggerholm</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Haematology, Aarhus University Hospital</institution>, Aarhus,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andrikovics, H" sort="Andrikovics, H" uniqKey="Andrikovics H" first="H" last="Andrikovics">H. Andrikovics</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Hungarian National Blood Transfusion Service</institution>, Budapest,<country>Hungary</country></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Akiki, S" sort="Akiki, S" uniqKey="Akiki S" first="S" last="Akiki">S. Akiki</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Regional Genetics Laboratory, Birmingham Women's NHS Foundation Trust</institution>, Birmingham,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barbany, G" sort="Barbany, G" uniqKey="Barbany G" first="G" last="Barbany">G. Barbany</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Molecular Medicine and Surgery, Clinical Genetics Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boeckx, N" sort="Boeckx, N" uniqKey="Boeckx N" first="N" last="Boeckx">N. Boeckx</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Laboratory Medicine</institution>, UZ Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Oncology, KU</institution> Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bench, A" sort="Bench, A" uniqKey="Bench A" first="A" last="Bench">A. Bench</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Molecular Malignancy Laboratory and Haemato-Oncology Diagnostic Service, Cambridge University Hospitals NHS Foundation Trust</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Catherwood, M" sort="Catherwood, M" uniqKey="Catherwood M" first="M" last="Catherwood">M. Catherwood</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Haematology Department, Belfast City Hospital</institution>, Belfast,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cayuela, J M" sort="Cayuela, J M" uniqKey="Cayuela J" first="J-M" last="Cayuela">J-M Cayuela</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Haematology Laboratory and EA3518, University Hospital Saint-Louis, AP-HP, University Paris Diderot</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chudleigh, S" sort="Chudleigh, S" uniqKey="Chudleigh S" first="S" last="Chudleigh">S. Chudleigh</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Department of Molecular Haematology, Yorkhill NHS Trust</institution>, Glasgow,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Clench, T" sort="Clench, T" uniqKey="Clench T" first="T" last="Clench">T. Clench</name><affiliation wicri:level="1"><nlm:aff id="aff14">Molecular Haematology, Bristol Royal Infirmary, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular Haematology, Bristol Royal Infirmary, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Colomer, D" sort="Colomer, D" uniqKey="Colomer D" first="D" last="Colomer">D. Colomer</name><affiliation wicri:level="3"><nlm:aff id="aff15">Hematopathology Unit, Hospital Clinic, IDIBAPS, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hematopathology Unit, Hospital Clinic, IDIBAPS, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Daraio, F" sort="Daraio, F" uniqKey="Daraio F" first="F" last="Daraio">F. Daraio</name><affiliation wicri:level="3"><nlm:aff id="aff16">Department of Clinical and Biological Science, University of Turin, Turin, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical and Biological Science, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Dulucq, S" sort="Dulucq, S" uniqKey="Dulucq S" first="S" last="Dulucq">S. Dulucq</name><affiliation wicri:level="3"><nlm:aff id="aff17">Laboratoire Hematologie, CHU Bordeaux, Hematopoiese Leucemique et Cibles Therapeutiques, INSERM U1035, Universite Bordeaux, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Hematologie, CHU Bordeaux, Hematopoiese Leucemique et Cibles Therapeutiques, INSERM U1035, Universite Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Farrugia, J" sort="Farrugia, J" uniqKey="Farrugia J" first="J" last="Farrugia">J. Farrugia</name><affiliation wicri:level="1"><nlm:aff id="aff18">Combined Laboratories, Derriford Hospital, Plymouth, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Combined Laboratories, Derriford Hospital, Plymouth</wicri:regionArea><wicri:noRegion>Plymouth</wicri:noRegion></affiliation></author><author><name sortKey="Fletcher, L" sort="Fletcher, L" uniqKey="Fletcher L" first="L" last="Fletcher">L. Fletcher</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation></author><author><name sortKey="Foroni, L" sort="Foroni, L" uniqKey="Foroni L" first="L" last="Foroni">L. Foroni</name><affiliation wicri:level="3"><nlm:aff id="aff20">Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ganderton, R" sort="Ganderton, R" uniqKey="Ganderton R" first="R" last="Ganderton">R. Ganderton</name><affiliation wicri:level="1"><nlm:aff id="aff21">Molecular Pathology, University Hospitals Southampton NHS Foundation Trust, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular Pathology, University Hospitals Southampton NHS Foundation Trust, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Gerrard, G" sort="Gerrard, G" uniqKey="Gerrard G" first="G" last="Gerrard">G. Gerrard</name><affiliation wicri:level="3"><nlm:aff id="aff20">Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gineikien, E" sort="Gineikien, E" uniqKey="Gineikien E" first="E" last="Gineikien">E. Gineikien</name><affiliation wicri:level="1"><nlm:aff id="aff22">Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Hayette, S" sort="Hayette, S" uniqKey="Hayette S" first="S" last="Hayette">S. Hayette</name><affiliation wicri:level="1"><nlm:aff id="aff23">Laboratory of Molecular Biology and UMR5239, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre Bénite, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Molecular Biology and UMR5239, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre Bénite</wicri:regionArea><wicri:noRegion>Pierre Bénite</wicri:noRegion><wicri:noRegion>Pierre Bénite</wicri:noRegion></affiliation></author><author><name sortKey="El Housni, H" sort="El Housni, H" uniqKey="El Housni H" first="H" last="El Housni">H. El Housni</name><affiliation wicri:level="3"><nlm:aff id="aff24">Medical Genetics Department, Erasme Hospital, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Medical Genetics Department, Erasme Hospital, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Izzo, B" sort="Izzo, B" uniqKey="Izzo B" first="B" last="Izzo">B. Izzo</name><affiliation wicri:level="1"><nlm:aff id="aff25">Department of Clinical Medicine and Surgery, University ‘Federico II' of Naples, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Medicine and Surgery, University ‘Federico II' of Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Jansson, M" sort="Jansson, M" uniqKey="Jansson M" first="M" last="Jansson">M. Jansson</name><affiliation wicri:level="4"><nlm:aff id="aff26">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Johnels, P" sort="Johnels, P" uniqKey="Johnels P" first="P" last="Johnels">P. Johnels</name><affiliation wicri:level="1"><nlm:aff id="aff27">Department of Clinical Genetics, University and Regional Laboratories, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Genetics, University and Regional Laboratories, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Jurcek, T" sort="Jurcek, T" uniqKey="Jurcek T" first="T" last="Jurcek">T. Jurcek</name><affiliation wicri:level="3"><nlm:aff id="aff28">Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital Brno, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Kairisto, V" sort="Kairisto, V" uniqKey="Kairisto V" first="V" last="Kairisto">V. Kairisto</name><affiliation wicri:level="3"><nlm:aff id="aff29">Turku University Hospital, TYKSLAB, Laboratory of Molecular Genetics, Turku, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Turku University Hospital, TYKSLAB, Laboratory of Molecular Genetics, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Kizilors, A" sort="Kizilors, A" uniqKey="Kizilors A" first="A" last="Kizilors">A. Kizilors</name><affiliation wicri:level="3"><nlm:aff id="aff30">Laboratory for Molecular Haemato-Oncology, Kings College Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Laboratory for Molecular Haemato-Oncology, Kings College Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kim, D W" sort="Kim, D W" uniqKey="Kim D" first="D-W" last="Kim">D-W Kim</name><affiliation wicri:level="3"><nlm:aff id="aff31">Cancer Research Institute, The Catholic University of Korea, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Cancer Research Institute, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lange, T" sort="Lange, T" uniqKey="Lange T" first="T" last="Lange">T. Lange</name><affiliation wicri:level="3"><nlm:aff id="aff32">Abteilung für Hämatologie und internistische Onkologie, Universität Leipzig, Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Abteilung für Hämatologie und internistische Onkologie, Universität Leipzig, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Lion, T" sort="Lion, T" uniqKey="Lion T" first="T" last="Lion">T. Lion</name><affiliation wicri:level="3"><nlm:aff id="aff33">Children's Cancer Research Institute/LabDia Labordiagnostik and Medical University, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute/LabDia Labordiagnostik and Medical University, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Polakova, K M" sort="Polakova, K M" uniqKey="Polakova K" first="K M" last="Polakova">K M Polakova</name><affiliation wicri:level="3"><nlm:aff id="aff34">Institute of Hematology and Blood Transfusion, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Hematology and Blood Transfusion, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Martinelli, G" sort="Martinelli, G" uniqKey="Martinelli G" first="G" last="Martinelli">G. Martinelli</name><affiliation wicri:level="1"><nlm:aff id="aff35">Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Mccarron, S" sort="Mccarron, S" uniqKey="Mccarron S" first="S" last="Mccarron">S. Mccarron</name><affiliation wicri:level="1"><nlm:aff id="aff36">Cancer Molecular Diagnostics, St James's Hospital, Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Cancer Molecular Diagnostics, St James's Hospital, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Merle, P A" sort="Merle, P A" uniqKey="Merle P" first="P A" last="Merle">P A Merle</name><affiliation wicri:level="3"><nlm:aff id="aff37">VU Medical Centre, Department of Haematology, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU Medical Centre, Department of Haematology, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Milner, B" sort="Milner, B" uniqKey="Milner B" first="B" last="Milner">B. Milner</name><affiliation wicri:level="1"><nlm:aff id="aff38">Department of Medical Genetics, NHS-Grampian, Aberdeen, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical Genetics, NHS-Grampian, Aberdeen</wicri:regionArea><wicri:noRegion>Aberdeen</wicri:noRegion></affiliation></author><author><name sortKey="Mitterbauer Hohendanner, G" sort="Mitterbauer Hohendanner, G" uniqKey="Mitterbauer Hohendanner G" first="G" last="Mitterbauer-Hohendanner">G. Mitterbauer-Hohendanner</name><affiliation wicri:level="3"><nlm:aff id="aff39">Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Laboratory Medicine, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Nagar, M" sort="Nagar, M" uniqKey="Nagar M" first="M" last="Nagar">M. Nagar</name><affiliation wicri:level="1"><nlm:aff id="aff40">Laboratory of Hematology, Sheba Medical Center, Tel Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Laboratory of Hematology, Sheba Medical Center, Tel Hashomer</wicri:regionArea><wicri:noRegion>Tel Hashomer</wicri:noRegion></affiliation></author><author><name sortKey="Nickless, G" sort="Nickless, G" uniqKey="Nickless G" first="G" last="Nickless">G. Nickless</name><affiliation wicri:level="3"><nlm:aff id="aff41">Molecular Oncology Diagnostics Unit, Guy's Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular Oncology Diagnostics Unit, Guy's Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Nomdedeu, J" sort="Nomdedeu, J" uniqKey="Nomdedeu J" first="J" last="Nomdedéu">J. Nomdedéu</name><affiliation wicri:level="3"><nlm:aff id="aff42">Lab Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Lab Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Nymoen, D A" sort="Nymoen, D A" uniqKey="Nymoen D" first="D A" last="Nymoen">D A Nymoen</name><affiliation wicri:level="3"><nlm:aff id="aff43">Division of Pathology, Rikshospital, Oslo University Hospital, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Division of Pathology, Rikshospital, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Leibundgut, E O" sort="Leibundgut, E O" uniqKey="Leibundgut E" first="E O" last="Leibundgut">E O Leibundgut</name><affiliation wicri:level="3"><nlm:aff id="aff44">Molecular Diagnostics Laboratory, Department of Hematology, University Hospital Bern, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Molecular Diagnostics Laboratory, Department of Hematology, University Hospital Bern, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Ozbek, U" sort="Ozbek, U" uniqKey="Ozbek U" first="U" last="Ozbek">U. Ozbek</name><affiliation wicri:level="1"><nlm:aff id="aff45">Genetics Department, Institute of Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Genetics Department, Institute of Experimental Medicine (DETAE), Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Paji, T" sort="Paji, T" uniqKey="Paji T" first="T" last="Paji">T. Paji</name><affiliation wicri:level="1"><nlm:aff id="aff46">Specialized Haematology Laboratory, Division of Internal Medicine, Department of Haematology, University Medical Centre, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Specialized Haematology Laboratory, Division of Internal Medicine, Department of Haematology, University Medical Centre, Ljubljana</wicri:regionArea><wicri:noRegion>Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Pfeifer, H" sort="Pfeifer, H" uniqKey="Pfeifer H" first="H" last="Pfeifer">H. Pfeifer</name><affiliation wicri:level="3"><nlm:aff id="aff47">Department of Internal Medicine, Hematology/Oncology, Goethe University, Frankfurt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine, Hematology/Oncology, Goethe University, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Preudhomme, C" sort="Preudhomme, C" uniqKey="Preudhomme C" first="C" last="Preudhomme">C. Preudhomme</name><affiliation wicri:level="3"><nlm:aff id="aff48">Laboratoire d'hématologie, CHU Lille, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'hématologie, CHU Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Raudsepp, K" sort="Raudsepp, K" uniqKey="Raudsepp K" first="K" last="Raudsepp">K. Raudsepp</name><affiliation wicri:level="1"><nlm:aff id="aff49">United Laboratories of Tartu University Hospitals, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>United Laboratories of Tartu University Hospitals, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Romeo, G" sort="Romeo, G" uniqKey="Romeo G" first="G" last="Romeo">G. Romeo</name><affiliation wicri:level="1"><nlm:aff id="aff50">Molecular Haematology Laboratory, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Haematology Laboratory, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Sacha, T" sort="Sacha, T" uniqKey="Sacha T" first="T" last="Sacha">T. Sacha</name><affiliation wicri:level="1"><nlm:aff id="aff51">Hematology Department, Jagiellonian University, Krakow, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Hematology Department, Jagiellonian University, Krakow</wicri:regionArea><wicri:noRegion>Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Talmaci, R" sort="Talmaci, R" uniqKey="Talmaci R" first="R" last="Talmaci">R. Talmaci</name><affiliation wicri:level="1"><nlm:aff id="aff52">Hematology Department, Fundeni Clinical Institute, University of Medicine and Pharmacy ‘Carol Davila', Bucharest, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Hematology Department, Fundeni Clinical Institute, University of Medicine and Pharmacy ‘Carol Davila', Bucharest</wicri:regionArea><wicri:noRegion>Bucharest</wicri:noRegion></affiliation></author><author><name sortKey="Touloumenidou, T" sort="Touloumenidou, T" uniqKey="Touloumenidou T" first="T" last="Touloumenidou">T. Touloumenidou</name><affiliation wicri:level="1"><nlm:aff id="aff53">Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Velden, V H J" sort="Van Der Velden, V H J" uniqKey="Van Der Velden V" first="V H J" last="Van Der Velden">V H J. Van Der Velden</name><affiliation wicri:level="3"><nlm:aff id="aff54">Department of Immunology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Immunology, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Waits, P" sort="Waits, P" uniqKey="Waits P" first="P" last="Waits">P. Waits</name><affiliation wicri:level="1"><nlm:aff id="aff55">Bristol Genetics Laboratory, Southmead Hospital, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bristol Genetics Laboratory, Southmead Hospital, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Wang, L" sort="Wang, L" uniqKey="Wang L" first="L" last="Wang">L. Wang</name><affiliation wicri:level="1"><nlm:aff id="aff56">Department of Haematology, Royal Liverpool University Hospital, Liverpool, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Royal Liverpool University Hospital, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Wilkinson, E" sort="Wilkinson, E" uniqKey="Wilkinson E" first="E" last="Wilkinson">E. Wilkinson</name><affiliation wicri:level="1"><nlm:aff id="aff57">HMDS, Leeds Institute of Oncology, St James's University Hospital, Leeds, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>HMDS, Leeds Institute of Oncology, St James's University Hospital, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, G" sort="Wilson, G" uniqKey="Wilson G" first="G" last="Wilson">G. Wilson</name><affiliation wicri:level="1"><nlm:aff id="aff58">Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Wren, D" sort="Wren, D" uniqKey="Wren D" first="D" last="Wren">D. Wren</name><affiliation wicri:level="1"><nlm:aff id="aff59">Molecular Diagnostics, The Royal Marsden NHS Foundation Trust, Sutton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular Diagnostics, The Royal Marsden NHS Foundation Trust, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Zadro, R" sort="Zadro, R" uniqKey="Zadro R" first="R" last="Zadro">R. Zadro</name><affiliation wicri:level="1"><nlm:aff id="aff60">Department of Laboratory Diagnostics, Clinical Hospital Center, Zagreb University School of Medicine, Zagreb, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Department of Laboratory Diagnostics, Clinical Hospital Center, Zagreb University School of Medicine, Zagreb</wicri:regionArea><wicri:noRegion>Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Ziermann, J" sort="Ziermann, J" uniqKey="Ziermann J" first="J" last="Ziermann">J. Ziermann</name><affiliation wicri:level="1"><nlm:aff id="aff61">Department of Hematology/Oncology, Jena University Hospital, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology/Oncology, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Zoi, K" sort="Zoi, K" uniqKey="Zoi K" first="K" last="Zoi">K. Zoi</name><affiliation wicri:level="3"><nlm:aff id="aff62">Haematology Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Haematology Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Muller, M C" sort="Muller, M C" uniqKey="Muller M" first="M C" last="Müller">M C Müller</name><affiliation wicri:level="3"><nlm:aff id="aff63">III. Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>III. Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Hochhaus, A" sort="Hochhaus, A" uniqKey="Hochhaus A" first="A" last="Hochhaus">A. Hochhaus</name><affiliation wicri:level="1"><nlm:aff id="aff61">Department of Hematology/Oncology, Jena University Hospital, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology/Oncology, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Schimmel, H" sort="Schimmel, H" uniqKey="Schimmel H" first="H" last="Schimmel">H. Schimmel</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>, Geel,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cross, N C P" sort="Cross, N C P" uniqKey="Cross N" first="N C P" last="Cross">N C P. Cross</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>, Salisbury,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Faculty of Medicine, University of Southampton</institution>, Southampton,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Emons, H" sort="Emons, H" uniqKey="Emons H" first="H" last="Emons">H. Emons</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>, Geel,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25036192</idno><idno type="pmc">4320294</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320294</idno><idno type="RBID">PMC:4320294</idno><idno type="doi">10.1038/leu.2014.217</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000100</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000100</idno><idno type="wicri:Area/Pmc/Curation">000100</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000100</idno><idno type="wicri:Area/Pmc/Checkpoint">001774</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001774</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A certified plasmid reference material for the standardisation of <italic>BCR–ABL1</italic> mRNA quantification by real-time quantitative PCR</title><author><name sortKey="White, H" sort="White, H" uniqKey="White H" first="H" last="White">H. White</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>, Salisbury,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Faculty of Medicine, University of Southampton</institution>, Southampton,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deprez, L" sort="Deprez, L" uniqKey="Deprez L" first="L" last="Deprez">L. Deprez</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>, Geel,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Corbisier, P" sort="Corbisier, P" uniqKey="Corbisier P" first="P" last="Corbisier">P. Corbisier</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>, Geel,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hall, V" sort="Hall, V" uniqKey="Hall V" first="V" last="Hall">V. Hall</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>, Salisbury,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, F" sort="Lin, F" uniqKey="Lin F" first="F" last="Lin">F. Lin</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>, Salisbury,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Faculty of Medicine, University of Southampton</institution>, Southampton,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mazoua, S" sort="Mazoua, S" uniqKey="Mazoua S" first="S" last="Mazoua">S. Mazoua</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>, Geel,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Trapmann, S" sort="Trapmann, S" uniqKey="Trapmann S" first="S" last="Trapmann">S. Trapmann</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>, Geel,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aggerholm, A" sort="Aggerholm, A" uniqKey="Aggerholm A" first="A" last="Aggerholm">A. Aggerholm</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Haematology, Aarhus University Hospital</institution>, Aarhus,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andrikovics, H" sort="Andrikovics, H" uniqKey="Andrikovics H" first="H" last="Andrikovics">H. Andrikovics</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Hungarian National Blood Transfusion Service</institution>, Budapest,<country>Hungary</country></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Akiki, S" sort="Akiki, S" uniqKey="Akiki S" first="S" last="Akiki">S. Akiki</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Regional Genetics Laboratory, Birmingham Women's NHS Foundation Trust</institution>, Birmingham,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barbany, G" sort="Barbany, G" uniqKey="Barbany G" first="G" last="Barbany">G. Barbany</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Molecular Medicine and Surgery, Clinical Genetics Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boeckx, N" sort="Boeckx, N" uniqKey="Boeckx N" first="N" last="Boeckx">N. Boeckx</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Laboratory Medicine</institution>, UZ Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Oncology, KU</institution> Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bench, A" sort="Bench, A" uniqKey="Bench A" first="A" last="Bench">A. Bench</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Molecular Malignancy Laboratory and Haemato-Oncology Diagnostic Service, Cambridge University Hospitals NHS Foundation Trust</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Catherwood, M" sort="Catherwood, M" uniqKey="Catherwood M" first="M" last="Catherwood">M. Catherwood</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Haematology Department, Belfast City Hospital</institution>, Belfast,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cayuela, J M" sort="Cayuela, J M" uniqKey="Cayuela J" first="J-M" last="Cayuela">J-M Cayuela</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Haematology Laboratory and EA3518, University Hospital Saint-Louis, AP-HP, University Paris Diderot</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chudleigh, S" sort="Chudleigh, S" uniqKey="Chudleigh S" first="S" last="Chudleigh">S. Chudleigh</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Department of Molecular Haematology, Yorkhill NHS Trust</institution>, Glasgow,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Clench, T" sort="Clench, T" uniqKey="Clench T" first="T" last="Clench">T. Clench</name><affiliation wicri:level="1"><nlm:aff id="aff14">Molecular Haematology, Bristol Royal Infirmary, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular Haematology, Bristol Royal Infirmary, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Colomer, D" sort="Colomer, D" uniqKey="Colomer D" first="D" last="Colomer">D. Colomer</name><affiliation wicri:level="3"><nlm:aff id="aff15">Hematopathology Unit, Hospital Clinic, IDIBAPS, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hematopathology Unit, Hospital Clinic, IDIBAPS, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Daraio, F" sort="Daraio, F" uniqKey="Daraio F" first="F" last="Daraio">F. Daraio</name><affiliation wicri:level="3"><nlm:aff id="aff16">Department of Clinical and Biological Science, University of Turin, Turin, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical and Biological Science, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Dulucq, S" sort="Dulucq, S" uniqKey="Dulucq S" first="S" last="Dulucq">S. Dulucq</name><affiliation wicri:level="3"><nlm:aff id="aff17">Laboratoire Hematologie, CHU Bordeaux, Hematopoiese Leucemique et Cibles Therapeutiques, INSERM U1035, Universite Bordeaux, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Hematologie, CHU Bordeaux, Hematopoiese Leucemique et Cibles Therapeutiques, INSERM U1035, Universite Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Farrugia, J" sort="Farrugia, J" uniqKey="Farrugia J" first="J" last="Farrugia">J. Farrugia</name><affiliation wicri:level="1"><nlm:aff id="aff18">Combined Laboratories, Derriford Hospital, Plymouth, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Combined Laboratories, Derriford Hospital, Plymouth</wicri:regionArea><wicri:noRegion>Plymouth</wicri:noRegion></affiliation></author><author><name sortKey="Fletcher, L" sort="Fletcher, L" uniqKey="Fletcher L" first="L" last="Fletcher">L. Fletcher</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation></author><author><name sortKey="Foroni, L" sort="Foroni, L" uniqKey="Foroni L" first="L" last="Foroni">L. Foroni</name><affiliation wicri:level="3"><nlm:aff id="aff20">Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ganderton, R" sort="Ganderton, R" uniqKey="Ganderton R" first="R" last="Ganderton">R. Ganderton</name><affiliation wicri:level="1"><nlm:aff id="aff21">Molecular Pathology, University Hospitals Southampton NHS Foundation Trust, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular Pathology, University Hospitals Southampton NHS Foundation Trust, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Gerrard, G" sort="Gerrard, G" uniqKey="Gerrard G" first="G" last="Gerrard">G. Gerrard</name><affiliation wicri:level="3"><nlm:aff id="aff20">Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gineikien, E" sort="Gineikien, E" uniqKey="Gineikien E" first="E" last="Gineikien">E. Gineikien</name><affiliation wicri:level="1"><nlm:aff id="aff22">Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Hayette, S" sort="Hayette, S" uniqKey="Hayette S" first="S" last="Hayette">S. Hayette</name><affiliation wicri:level="1"><nlm:aff id="aff23">Laboratory of Molecular Biology and UMR5239, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre Bénite, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Molecular Biology and UMR5239, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre Bénite</wicri:regionArea><wicri:noRegion>Pierre Bénite</wicri:noRegion><wicri:noRegion>Pierre Bénite</wicri:noRegion></affiliation></author><author><name sortKey="El Housni, H" sort="El Housni, H" uniqKey="El Housni H" first="H" last="El Housni">H. El Housni</name><affiliation wicri:level="3"><nlm:aff id="aff24">Medical Genetics Department, Erasme Hospital, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Medical Genetics Department, Erasme Hospital, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Izzo, B" sort="Izzo, B" uniqKey="Izzo B" first="B" last="Izzo">B. Izzo</name><affiliation wicri:level="1"><nlm:aff id="aff25">Department of Clinical Medicine and Surgery, University ‘Federico II' of Naples, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Medicine and Surgery, University ‘Federico II' of Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Jansson, M" sort="Jansson, M" uniqKey="Jansson M" first="M" last="Jansson">M. Jansson</name><affiliation wicri:level="4"><nlm:aff id="aff26">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Johnels, P" sort="Johnels, P" uniqKey="Johnels P" first="P" last="Johnels">P. Johnels</name><affiliation wicri:level="1"><nlm:aff id="aff27">Department of Clinical Genetics, University and Regional Laboratories, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Genetics, University and Regional Laboratories, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Jurcek, T" sort="Jurcek, T" uniqKey="Jurcek T" first="T" last="Jurcek">T. Jurcek</name><affiliation wicri:level="3"><nlm:aff id="aff28">Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital Brno, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Kairisto, V" sort="Kairisto, V" uniqKey="Kairisto V" first="V" last="Kairisto">V. Kairisto</name><affiliation wicri:level="3"><nlm:aff id="aff29">Turku University Hospital, TYKSLAB, Laboratory of Molecular Genetics, Turku, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Turku University Hospital, TYKSLAB, Laboratory of Molecular Genetics, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Kizilors, A" sort="Kizilors, A" uniqKey="Kizilors A" first="A" last="Kizilors">A. Kizilors</name><affiliation wicri:level="3"><nlm:aff id="aff30">Laboratory for Molecular Haemato-Oncology, Kings College Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Laboratory for Molecular Haemato-Oncology, Kings College Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kim, D W" sort="Kim, D W" uniqKey="Kim D" first="D-W" last="Kim">D-W Kim</name><affiliation wicri:level="3"><nlm:aff id="aff31">Cancer Research Institute, The Catholic University of Korea, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Cancer Research Institute, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lange, T" sort="Lange, T" uniqKey="Lange T" first="T" last="Lange">T. Lange</name><affiliation wicri:level="3"><nlm:aff id="aff32">Abteilung für Hämatologie und internistische Onkologie, Universität Leipzig, Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Abteilung für Hämatologie und internistische Onkologie, Universität Leipzig, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Lion, T" sort="Lion, T" uniqKey="Lion T" first="T" last="Lion">T. Lion</name><affiliation wicri:level="3"><nlm:aff id="aff33">Children's Cancer Research Institute/LabDia Labordiagnostik and Medical University, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute/LabDia Labordiagnostik and Medical University, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Polakova, K M" sort="Polakova, K M" uniqKey="Polakova K" first="K M" last="Polakova">K M Polakova</name><affiliation wicri:level="3"><nlm:aff id="aff34">Institute of Hematology and Blood Transfusion, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Hematology and Blood Transfusion, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Martinelli, G" sort="Martinelli, G" uniqKey="Martinelli G" first="G" last="Martinelli">G. Martinelli</name><affiliation wicri:level="1"><nlm:aff id="aff35">Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Mccarron, S" sort="Mccarron, S" uniqKey="Mccarron S" first="S" last="Mccarron">S. Mccarron</name><affiliation wicri:level="1"><nlm:aff id="aff36">Cancer Molecular Diagnostics, St James's Hospital, Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Cancer Molecular Diagnostics, St James's Hospital, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Merle, P A" sort="Merle, P A" uniqKey="Merle P" first="P A" last="Merle">P A Merle</name><affiliation wicri:level="3"><nlm:aff id="aff37">VU Medical Centre, Department of Haematology, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU Medical Centre, Department of Haematology, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Milner, B" sort="Milner, B" uniqKey="Milner B" first="B" last="Milner">B. Milner</name><affiliation wicri:level="1"><nlm:aff id="aff38">Department of Medical Genetics, NHS-Grampian, Aberdeen, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical Genetics, NHS-Grampian, Aberdeen</wicri:regionArea><wicri:noRegion>Aberdeen</wicri:noRegion></affiliation></author><author><name sortKey="Mitterbauer Hohendanner, G" sort="Mitterbauer Hohendanner, G" uniqKey="Mitterbauer Hohendanner G" first="G" last="Mitterbauer-Hohendanner">G. Mitterbauer-Hohendanner</name><affiliation wicri:level="3"><nlm:aff id="aff39">Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Laboratory Medicine, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Nagar, M" sort="Nagar, M" uniqKey="Nagar M" first="M" last="Nagar">M. Nagar</name><affiliation wicri:level="1"><nlm:aff id="aff40">Laboratory of Hematology, Sheba Medical Center, Tel Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Laboratory of Hematology, Sheba Medical Center, Tel Hashomer</wicri:regionArea><wicri:noRegion>Tel Hashomer</wicri:noRegion></affiliation></author><author><name sortKey="Nickless, G" sort="Nickless, G" uniqKey="Nickless G" first="G" last="Nickless">G. Nickless</name><affiliation wicri:level="3"><nlm:aff id="aff41">Molecular Oncology Diagnostics Unit, Guy's Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular Oncology Diagnostics Unit, Guy's Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Nomdedeu, J" sort="Nomdedeu, J" uniqKey="Nomdedeu J" first="J" last="Nomdedéu">J. Nomdedéu</name><affiliation wicri:level="3"><nlm:aff id="aff42">Lab Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Lab Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Nymoen, D A" sort="Nymoen, D A" uniqKey="Nymoen D" first="D A" last="Nymoen">D A Nymoen</name><affiliation wicri:level="3"><nlm:aff id="aff43">Division of Pathology, Rikshospital, Oslo University Hospital, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Division of Pathology, Rikshospital, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Leibundgut, E O" sort="Leibundgut, E O" uniqKey="Leibundgut E" first="E O" last="Leibundgut">E O Leibundgut</name><affiliation wicri:level="3"><nlm:aff id="aff44">Molecular Diagnostics Laboratory, Department of Hematology, University Hospital Bern, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Molecular Diagnostics Laboratory, Department of Hematology, University Hospital Bern, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Ozbek, U" sort="Ozbek, U" uniqKey="Ozbek U" first="U" last="Ozbek">U. Ozbek</name><affiliation wicri:level="1"><nlm:aff id="aff45">Genetics Department, Institute of Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Genetics Department, Institute of Experimental Medicine (DETAE), Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Paji, T" sort="Paji, T" uniqKey="Paji T" first="T" last="Paji">T. Paji</name><affiliation wicri:level="1"><nlm:aff id="aff46">Specialized Haematology Laboratory, Division of Internal Medicine, Department of Haematology, University Medical Centre, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Specialized Haematology Laboratory, Division of Internal Medicine, Department of Haematology, University Medical Centre, Ljubljana</wicri:regionArea><wicri:noRegion>Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Pfeifer, H" sort="Pfeifer, H" uniqKey="Pfeifer H" first="H" last="Pfeifer">H. Pfeifer</name><affiliation wicri:level="3"><nlm:aff id="aff47">Department of Internal Medicine, Hematology/Oncology, Goethe University, Frankfurt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine, Hematology/Oncology, Goethe University, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Preudhomme, C" sort="Preudhomme, C" uniqKey="Preudhomme C" first="C" last="Preudhomme">C. Preudhomme</name><affiliation wicri:level="3"><nlm:aff id="aff48">Laboratoire d'hématologie, CHU Lille, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'hématologie, CHU Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Raudsepp, K" sort="Raudsepp, K" uniqKey="Raudsepp K" first="K" last="Raudsepp">K. Raudsepp</name><affiliation wicri:level="1"><nlm:aff id="aff49">United Laboratories of Tartu University Hospitals, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>United Laboratories of Tartu University Hospitals, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Romeo, G" sort="Romeo, G" uniqKey="Romeo G" first="G" last="Romeo">G. Romeo</name><affiliation wicri:level="1"><nlm:aff id="aff50">Molecular Haematology Laboratory, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Haematology Laboratory, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Sacha, T" sort="Sacha, T" uniqKey="Sacha T" first="T" last="Sacha">T. Sacha</name><affiliation wicri:level="1"><nlm:aff id="aff51">Hematology Department, Jagiellonian University, Krakow, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Hematology Department, Jagiellonian University, Krakow</wicri:regionArea><wicri:noRegion>Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Talmaci, R" sort="Talmaci, R" uniqKey="Talmaci R" first="R" last="Talmaci">R. Talmaci</name><affiliation wicri:level="1"><nlm:aff id="aff52">Hematology Department, Fundeni Clinical Institute, University of Medicine and Pharmacy ‘Carol Davila', Bucharest, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Hematology Department, Fundeni Clinical Institute, University of Medicine and Pharmacy ‘Carol Davila', Bucharest</wicri:regionArea><wicri:noRegion>Bucharest</wicri:noRegion></affiliation></author><author><name sortKey="Touloumenidou, T" sort="Touloumenidou, T" uniqKey="Touloumenidou T" first="T" last="Touloumenidou">T. Touloumenidou</name><affiliation wicri:level="1"><nlm:aff id="aff53">Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Velden, V H J" sort="Van Der Velden, V H J" uniqKey="Van Der Velden V" first="V H J" last="Van Der Velden">V H J. Van Der Velden</name><affiliation wicri:level="3"><nlm:aff id="aff54">Department of Immunology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Immunology, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Waits, P" sort="Waits, P" uniqKey="Waits P" first="P" last="Waits">P. Waits</name><affiliation wicri:level="1"><nlm:aff id="aff55">Bristol Genetics Laboratory, Southmead Hospital, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bristol Genetics Laboratory, Southmead Hospital, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Wang, L" sort="Wang, L" uniqKey="Wang L" first="L" last="Wang">L. Wang</name><affiliation wicri:level="1"><nlm:aff id="aff56">Department of Haematology, Royal Liverpool University Hospital, Liverpool, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Royal Liverpool University Hospital, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Wilkinson, E" sort="Wilkinson, E" uniqKey="Wilkinson E" first="E" last="Wilkinson">E. Wilkinson</name><affiliation wicri:level="1"><nlm:aff id="aff57">HMDS, Leeds Institute of Oncology, St James's University Hospital, Leeds, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>HMDS, Leeds Institute of Oncology, St James's University Hospital, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, G" sort="Wilson, G" uniqKey="Wilson G" first="G" last="Wilson">G. Wilson</name><affiliation wicri:level="1"><nlm:aff id="aff58">Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Wren, D" sort="Wren, D" uniqKey="Wren D" first="D" last="Wren">D. Wren</name><affiliation wicri:level="1"><nlm:aff id="aff59">Molecular Diagnostics, The Royal Marsden NHS Foundation Trust, Sutton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular Diagnostics, The Royal Marsden NHS Foundation Trust, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Zadro, R" sort="Zadro, R" uniqKey="Zadro R" first="R" last="Zadro">R. Zadro</name><affiliation wicri:level="1"><nlm:aff id="aff60">Department of Laboratory Diagnostics, Clinical Hospital Center, Zagreb University School of Medicine, Zagreb, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Department of Laboratory Diagnostics, Clinical Hospital Center, Zagreb University School of Medicine, Zagreb</wicri:regionArea><wicri:noRegion>Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Ziermann, J" sort="Ziermann, J" uniqKey="Ziermann J" first="J" last="Ziermann">J. Ziermann</name><affiliation wicri:level="1"><nlm:aff id="aff61">Department of Hematology/Oncology, Jena University Hospital, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology/Oncology, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Zoi, K" sort="Zoi, K" uniqKey="Zoi K" first="K" last="Zoi">K. Zoi</name><affiliation wicri:level="3"><nlm:aff id="aff62">Haematology Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Haematology Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Muller, M C" sort="Muller, M C" uniqKey="Muller M" first="M C" last="Müller">M C Müller</name><affiliation wicri:level="3"><nlm:aff id="aff63">III. Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>III. Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Hochhaus, A" sort="Hochhaus, A" uniqKey="Hochhaus A" first="A" last="Hochhaus">A. Hochhaus</name><affiliation wicri:level="1"><nlm:aff id="aff61">Department of Hematology/Oncology, Jena University Hospital, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology/Oncology, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Schimmel, H" sort="Schimmel, H" uniqKey="Schimmel H" first="H" last="Schimmel">H. Schimmel</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>, Geel,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cross, N C P" sort="Cross, N C P" uniqKey="Cross N" first="N C P" last="Cross">N C P. Cross</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>, Salisbury,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Faculty of Medicine, University of Southampton</institution>, Southampton,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Emons, H" sort="Emons, H" uniqKey="Emons H" first="H" last="Emons">H. Emons</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>, Geel,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Leukemia</title><idno type="ISSN">0887-6924</idno><idno type="eISSN">1476-5551</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Serial quantification of <italic>BCR–ABL1</italic> mRNA is an important therapeutic indicator in chronic myeloid leukaemia, but there is a substantial variation in results reported by different laboratories. To improve comparability, an internationally accepted plasmid certified reference material (CRM) was developed according to ISO Guide 34:2009. Fragments of <italic>BCR–ABL1</italic> (e14a2 mRNA fusion)<italic>, BCR</italic> and <italic>GUSB</italic> transcripts were amplified and cloned into pUC18 to yield plasmid pIRMM0099. Six different linearised plasmid solutions were produced with the following copy number concentrations, assigned by digital PCR, and expanded uncertainties: 1.08±0.13 × 10<sup>6</sup>, 1.08±0.11 × 10<sup>5</sup>, 1.03±0.10 × 10<sup>4</sup>, 1.02±0.09 × 10<sup>3</sup>, 1.04±0.10 × 10<sup>2</sup> and 10.0±1.5 copies/μl. The certification of the material for the number of specific DNA fragments per plasmid, copy number concentration of the plasmid solutions and the assessment of inter-unit heterogeneity and stability were performed according to ISO Guide 35:2006. Two suitability studies performed by 63 <italic>BCR–ABL1</italic> testing laboratories demonstrated that this set of 6 plasmid CRMs can help to standardise a number of measured transcripts of e14a2 <italic>BCR–ABL1</italic> and three control genes (<italic>ABL1, BCR</italic> and <italic>GUSB</italic>). The set of six plasmid CRMs is distributed worldwide by the Institute for Reference Materials and Measurements (Belgium) and its authorised distributors (<ext-link ext-link-type="uri" xlink:href="https://ec.europa.eu/jrc/en/reference-materials/catalogue/">https://ec.europa.eu/jrc/en/reference-materials/catalogue/</ext-link>; CRM code ERM-AD623a-f).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cross, Nc" uniqKey="Cross N">NC Cross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Press, Rd" uniqKey="Press R">RD Press</name></author><author><name sortKey="Kamel Reid, S" uniqKey="Kamel Reid S">S Kamel-Reid</name></author><author><name sortKey="Ang, D" uniqKey="Ang D">D Ang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Branford, S" uniqKey="Branford S">S Branford</name></author><author><name sortKey="Prime, J" uniqKey="Prime J">J 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Leukemia</journal-id><journal-id journal-id-type="iso-abbrev">Leukemia</journal-id><journal-title-group><journal-title>Leukemia</journal-title></journal-title-group><issn pub-type="ppub">0887-6924</issn><issn pub-type="epub">1476-5551</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25036192</article-id><article-id pub-id-type="pmc">4320294</article-id><article-id pub-id-type="pii">leu2014217</article-id><article-id pub-id-type="doi">10.1038/leu.2014.217</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>A certified plasmid reference material for the standardisation of <italic>BCR–ABL1</italic> mRNA quantification by real-time quantitative PCR</article-title><alt-title alt-title-type="running">Certified plasmid reference material of <italic>BCR–ABL1</italic> mRNA</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>White</surname><given-names>H</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="corresp" rid="caf1">*</xref></contrib><contrib contrib-type="author"><name><surname>Deprez</surname><given-names>L</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="corresp" rid="caf2">*</xref></contrib><contrib contrib-type="author"><name><surname>Corbisier</surname><given-names>P</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>V</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>F</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mazoua</surname><given-names>S</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Trapmann</surname><given-names>S</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Aggerholm</surname><given-names>A</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Andrikovics</surname><given-names>H</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Akiki</surname><given-names>S</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Barbany</surname><given-names>G</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Boeckx</surname><given-names>N</given-names></name><xref ref-type="aff" rid="aff8">8</xref><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Bench</surname><given-names>A</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Catherwood</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Cayuela</surname><given-names>J-M</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Chudleigh</surname><given-names>S</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Clench</surname><given-names>T</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Colomer</surname><given-names>D</given-names></name><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib 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contrib-type="author"><name><surname>Emons</surname><given-names>H</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><aff id="aff1"><label>1</label><institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>, Salisbury,<country>UK</country></aff><aff id="aff2"><label>2</label><institution>Faculty of Medicine, University of Southampton</institution>, Southampton,<country>UK</country></aff><aff id="aff3"><label>3</label><institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>, Geel,<country>Belgium</country></aff><aff id="aff4"><label>4</label><institution>Department of Haematology, Aarhus University Hospital</institution>, Aarhus,<country>Denmark</country></aff><aff id="aff5"><label>5</label><institution>Hungarian National Blood Transfusion Service</institution>, Budapest,<country>Hungary</country></aff><aff id="aff6"><label>6</label><institution>Regional Genetics Laboratory, Birmingham Women's NHS Foundation Trust</institution>, Birmingham,<country>UK</country></aff><aff id="aff7"><label>7</label><institution>Department of Molecular Medicine and Surgery, Clinical Genetics Karolinska Institutet</institution>, Stockholm,<country>Sweden</country></aff><aff id="aff8"><label>8</label><institution>Department of Laboratory Medicine</institution>, UZ Leuven,<country>Belgium</country></aff><aff id="aff9"><label>9</label><institution>Department of Oncology, KU</institution> Leuven,<country>Belgium</country></aff><aff id="aff10"><label>10</label><institution>Molecular Malignancy Laboratory and Haemato-Oncology Diagnostic Service, Cambridge University Hospitals NHS Foundation Trust</institution>, Cambridge,<country>UK</country></aff><aff id="aff11"><label>11</label><institution>Haematology Department, Belfast City Hospital</institution>, Belfast,<country>UK</country></aff><aff id="aff12"><label>12</label><institution>Haematology Laboratory and EA3518, University Hospital Saint-Louis, AP-HP, University Paris Diderot</institution>, Paris,<country>France</country></aff><aff id="aff13"><label>13</label><institution>Department of Molecular Haematology, Yorkhill NHS Trust</institution>, Glasgow,<country>UK</country></aff><aff id="aff14"><label>14</label>Molecular Haematology, Bristol Royal Infirmary, Bristol, UK</aff><aff id="aff15"><label>15</label>Hematopathology Unit, Hospital Clinic, IDIBAPS, Barcelona, Spain</aff><aff id="aff16"><label>16</label>Department of Clinical and Biological Science, University of Turin, Turin, Italy</aff><aff id="aff17"><label>17</label>Laboratoire Hematologie, CHU Bordeaux, Hematopoiese Leucemique et Cibles Therapeutiques, INSERM U1035, Universite Bordeaux, Bordeaux, France</aff><aff id="aff18"><label>18</label>Combined Laboratories, Derriford Hospital, Plymouth, UK</aff><aff id="aff19"><label>19</label>Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia</aff><aff id="aff20"><label>20</label>Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London, UK</aff><aff id="aff21"><label>21</label>Molecular Pathology, University Hospitals Southampton NHS Foundation Trust, Southampton, UK</aff><aff id="aff22"><label>22</label>Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania</aff><aff id="aff23"><label>23</label>Laboratory of Molecular Biology and UMR5239, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre Bénite, France</aff><aff id="aff24"><label>24</label>Medical Genetics Department, Erasme Hospital, Brussels, Belgium</aff><aff id="aff25"><label>25</label>Department of Clinical Medicine and Surgery, University ‘Federico II' of Naples, Naples, Italy</aff><aff id="aff26"><label>26</label>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</aff><aff id="aff27"><label>27</label>Department of Clinical Genetics, University and Regional Laboratories, Lund, Sweden</aff><aff id="aff28"><label>28</label>Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic</aff><aff id="aff29"><label>29</label>Turku University Hospital, TYKSLAB, Laboratory of Molecular Genetics, Turku, Finland</aff><aff id="aff30"><label>30</label>Laboratory for Molecular Haemato-Oncology, Kings College Hospital, London, UK</aff><aff id="aff31"><label>31</label>Cancer Research Institute, The Catholic University of Korea, Seoul, South Korea</aff><aff id="aff32"><label>32</label>Abteilung für Hämatologie und internistische Onkologie, Universität Leipzig, Leipzig, Germany</aff><aff id="aff33"><label>33</label>Children's Cancer Research Institute/LabDia Labordiagnostik and Medical University, Vienna, Austria</aff><aff id="aff34"><label>34</label>Institute of Hematology and Blood Transfusion, Prague, Czech Republic</aff><aff id="aff35"><label>35</label>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy</aff><aff id="aff36"><label>36</label>Cancer Molecular Diagnostics, St James's Hospital, Dublin, Ireland</aff><aff id="aff37"><label>37</label>VU Medical Centre, Department of Haematology, Amsterdam, The Netherlands</aff><aff id="aff38"><label>38</label>Department of Medical Genetics, NHS-Grampian, Aberdeen, UK</aff><aff id="aff39"><label>39</label>Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria</aff><aff id="aff40"><label>40</label>Laboratory of Hematology, Sheba Medical Center, Tel Hashomer, Israel</aff><aff id="aff41"><label>41</label>Molecular Oncology Diagnostics Unit, Guy's Hospital, London, UK</aff><aff id="aff42"><label>42</label>Lab Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</aff><aff id="aff43"><label>43</label>Division of Pathology, Rikshospital, Oslo University Hospital, Oslo, Norway</aff><aff id="aff44"><label>44</label>Molecular Diagnostics Laboratory, Department of Hematology, University Hospital Bern, Bern, Switzerland</aff><aff id="aff45"><label>45</label>Genetics Department, Institute of Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey</aff><aff id="aff46"><label>46</label>Specialized Haematology Laboratory, Division of Internal Medicine, Department of Haematology, University Medical Centre, Ljubljana, Slovenia</aff><aff id="aff47"><label>47</label>Department of Internal Medicine, Hematology/Oncology, Goethe University, Frankfurt, Germany</aff><aff id="aff48"><label>48</label>Laboratoire d'hématologie, CHU Lille, Lille, France</aff><aff id="aff49"><label>49</label>United Laboratories of Tartu University Hospitals, Tartu, Estonia</aff><aff id="aff50"><label>50</label>Molecular Haematology Laboratory, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA, Australia</aff><aff id="aff51"><label>51</label>Hematology Department, Jagiellonian University, Krakow, Poland</aff><aff id="aff52"><label>52</label>Hematology Department, Fundeni Clinical Institute, University of Medicine and Pharmacy ‘Carol Davila', Bucharest, Romania</aff><aff id="aff53"><label>53</label>Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece</aff><aff id="aff54"><label>54</label>Department of Immunology, Erasmus MC, Rotterdam, The Netherlands</aff><aff id="aff55"><label>55</label>Bristol Genetics Laboratory, Southmead Hospital, Bristol, UK</aff><aff id="aff56"><label>56</label>Department of Haematology, Royal Liverpool University Hospital, Liverpool, UK</aff><aff id="aff57"><label>57</label>HMDS, Leeds Institute of Oncology, St James's University Hospital, Leeds, UK</aff><aff id="aff58"><label>58</label>Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK</aff><aff id="aff59"><label>59</label>Molecular Diagnostics, The Royal Marsden NHS Foundation Trust, Sutton, UK</aff><aff id="aff60"><label>60</label>Department of Laboratory Diagnostics, Clinical Hospital Center, Zagreb University School of Medicine, Zagreb, Croatia</aff><aff id="aff61"><label>61</label>Department of Hematology/Oncology, Jena University Hospital, Jena, Germany</aff><aff id="aff62"><label>62</label>Haematology Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens, Greece</aff><aff id="aff63"><label>63</label>III. Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany</aff></contrib-group><author-notes><corresp id="caf1"><label>*</label><institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>, Salisbury SP2 8BJ, <country>UK</country>E-mail: <email>hew@soton.ac.uk</email></corresp><corresp id="caf2"><label>*</label><institution>European Commission, Joint Research Centre (JRC), Institute for Reference Materials and Measurements (IRMM), Retieseweg 111</institution>, Geel 2440, <country>Belgium</country>. E-mail: <email>Liesbet.DEPREZ@ec.europa.eu</email></corresp></author-notes><pub-date pub-type="ppub"><month>02</month><year>2015</year></pub-date><pub-date pub-type="epreprint"><day>18</day><month>07</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>12</day><month>08</month><year>2014</year></pub-date><volume>29</volume><issue>2</issue><fpage>369</fpage><lpage>376</lpage><history><date date-type="received"><day>31</day><month>03</month><year>2014</year></date><date date-type="rev-recd"><day>21</day><month>05</month><year>2014</year></date><date date-type="accepted"><day>25</day><month>06</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2015 Macmillan Publishers Limited</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Macmillan Publishers Limited</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link></license-p></license></permissions><abstract><p>Serial quantification of <italic>BCR–ABL1</italic> mRNA is an important therapeutic indicator in chronic myeloid leukaemia, but there is a substantial variation in results reported by different laboratories. To improve comparability, an internationally accepted plasmid certified reference material (CRM) was developed according to ISO Guide 34:2009. Fragments of <italic>BCR–ABL1</italic> (e14a2 mRNA fusion)<italic>, BCR</italic> and <italic>GUSB</italic> transcripts were amplified and cloned into pUC18 to yield plasmid pIRMM0099. Six different linearised plasmid solutions were produced with the following copy number concentrations, assigned by digital PCR, and expanded uncertainties: 1.08±0.13 × 10<sup>6</sup>, 1.08±0.11 × 10<sup>5</sup>, 1.03±0.10 × 10<sup>4</sup>, 1.02±0.09 × 10<sup>3</sup>, 1.04±0.10 × 10<sup>2</sup> and 10.0±1.5 copies/μl. The certification of the material for the number of specific DNA fragments per plasmid, copy number concentration of the plasmid solutions and the assessment of inter-unit heterogeneity and stability were performed according to ISO Guide 35:2006. Two suitability studies performed by 63 <italic>BCR–ABL1</italic> testing laboratories demonstrated that this set of 6 plasmid CRMs can help to standardise a number of measured transcripts of e14a2 <italic>BCR–ABL1</italic> and three control genes (<italic>ABL1, BCR</italic> and <italic>GUSB</italic>). The set of six plasmid CRMs is distributed worldwide by the Institute for Reference Materials and Measurements (Belgium) and its authorised distributors (<ext-link ext-link-type="uri" xlink:href="https://ec.europa.eu/jrc/en/reference-materials/catalogue/">https://ec.europa.eu/jrc/en/reference-materials/catalogue/</ext-link>; CRM code ERM-AD623a-f).</p></abstract></article-meta></front><floats-group><fig id="fig1"><label>Figure 1</label><caption><p>Schematic map of the multitarget plasmid pIRMM0099. The arrows represent the inserts from the transcript fragments of <italic>BCR</italic>, <italic>GUSB</italic> and <italic>BCR–ABL1</italic>. The rectangles show the location of the PCR targets <italic>BCR–ABL1</italic> and <italic>ABL1</italic> (the <italic>ABL1</italic> CG is within the <italic>BCR–ABL1</italic> fragment) used quantify the copy number concentration of the plasmid. The single restriction site for <italic>Eco</italic>RV is also shown.</p></caption><graphic xlink:href="leu2014217f1"></graphic></fig><fig id="fig2"><label>Figure 2</label><caption><p>Comparison of measured % <italic>BCR-ABL1/ABL1</italic> ratio between laboratory calibrators (Lab) and ERM-AD623 for the cell line dilutions. Data from all centres in the second suitability study that used <italic>ABL1</italic> as a control gene are included; median values are indicated.</p></caption><graphic xlink:href="leu2014217f2"></graphic></fig><fig id="fig3"><label>Figure 3</label><caption><p>Comparison of measured % <italic>BCR-ABL1/ABL1</italic> ratio between laboratory calibrators (Lab) and ERM-AD623 for the aRNA mixtures. Data from all centres in the second suitability study that used <italic>ABL1</italic> as a control gene and returned aRNA data are included; median values are indicated.</p></caption><graphic xlink:href="leu2014217f3"></graphic></fig><fig id="fig4"><label>Figure 4</label><caption><p>Reported numbers of <italic>BCR–ABL1</italic> and <italic>ABL1</italic> transcripts using laboratory-specific methods (which vary with regard to the amount of material analysed), laboratory calibrators (Lab) and ERM-AD623 for cell line dilutions. Data from all centres in the second suitability study that used <italic>ABL1</italic> as a control gene are included; median values are indicated. Values for <italic>ABL1</italic> are for all three dilutions combined; values for <italic>BCR–ABL1</italic> differ between the three levels and are shown separately.</p></caption><graphic xlink:href="leu2014217f4"></graphic></fig><fig id="fig5"><label>Figure 5</label><caption><p>Estimates of copy numbers of <italic>BCR–ABL1</italic> and <italic>ABL1</italic> transcripts using laboratory calibrators and ERM-AD623 for the aRNA dilutions in the second suitability study. Individual laboratory protocols have been taken into account to derive estimate per μl of aRNA. Data from all centres in the second suitability study that used <italic>ABL1</italic> as a control gene and returned aRNA data are included; median values are indicated. Values for <italic>ABL1</italic> are for both dilutions combined; values for <italic>BCR–ABL1</italic> differ between the two levels and are shown separately. Expected values for <italic>ABL1</italic> if the lysis, reverse transcription and qPCR were all perfect is 305 500; expected <italic>BCR–ABL1</italic> values for levels 1 and 2 are 300 and 30, respectively.</p></caption><graphic xlink:href="leu2014217f5"></graphic></fig><table-wrap id="tbl1"><label>Table 1</label><caption><title>Certified copy number concentrations of double-stranded plasmid DNA and their uncertainties for the six ERM-AD623 dilutions</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="char"></col><col align="char"></col><col align="char"></col><col align="char"></col><col align="char"></col><col align="char"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><italic>CRM</italic></th><th align="center" valign="top" charoff="50"><italic>Copy number<xref ref-type="fn" rid="t1-fn2">a</xref> concentration of the plasmid (cp/μl)</italic></th><th align="center" valign="top" charoff="50">u<italic><sub>char,rel</sub> (%)</italic></th><th align="center" valign="top" charoff="50">u<italic><sub>bb,</sub><sub>rel</sub> (%)</italic></th><th align="center" valign="top" charoff="50">u<italic><sub>lts</sub><sub>,</sub><sub>rel</sub> (%)</italic></th><th align="center" valign="top" charoff="50">u<italic><sub>CRM</sub><sub>,rel</sub> (%)</italic></th><th align="center" valign="top" charoff="50">u<italic><sub>CRM</sub> (cp/μl)</italic></th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">ERM-AD623a</td><td align="center" valign="top" charoff="50">1.08 × 10<sup>6</sup></td><td align="center" valign="top" charoff="50">3.28</td><td align="center" valign="top" charoff="50">3.57</td><td align="center" valign="top" charoff="50">2.75</td><td align="center" valign="top" charoff="50">11.15</td><td align="center" valign="top" charoff="50">0.13 × 10<sup>6</sup></td></tr><tr><td align="left" valign="top" charoff="50">ERM-AD623b</td><td align="center" valign="top" charoff="50">1.08 × 10<sup>5</sup></td><td align="center" valign="top" charoff="50">3.58</td><td align="center" valign="top" charoff="50">2.88</td><td align="center" valign="top" charoff="50">2.21</td><td align="center" valign="top" charoff="50">10.19</td><td align="center" valign="top" charoff="50">0.11 × 10<sup>5</sup></td></tr><tr><td align="left" valign="top" charoff="50">ERM-AD623c</td><td align="center" valign="top" charoff="50">1.03 × 10<sup>4</sup></td><td align="center" valign="top" charoff="50">3.01</td><td align="center" valign="top" charoff="50">2.59</td><td align="center" valign="top" charoff="50">2.81</td><td align="center" valign="top" charoff="50">9.73</td><td align="center" valign="top" charoff="50">0.10 × 10<sup>4</sup></td></tr><tr><td align="left" valign="top" charoff="50">ERM-AD623d</td><td align="center" valign="top" charoff="50">1.02 × 10<sup>3</sup></td><td align="center" valign="top" charoff="50">2.66</td><td align="center" valign="top" charoff="50">2.47</td><td align="center" valign="top" charoff="50">2.11</td><td align="center" valign="top" charoff="50">8.40</td><td align="center" valign="top" charoff="50">0.09 × 10<sup>3</sup></td></tr><tr><td align="left" valign="top" charoff="50">ERM-AD623e</td><td align="center" valign="top" charoff="50">1.04 × 10<sup>2</sup></td><td align="center" valign="top" charoff="50">3.06</td><td align="center" valign="top" charoff="50">2.75</td><td align="center" valign="top" charoff="50">2.43</td><td align="center" valign="top" charoff="50">9.56</td><td align="center" valign="top" charoff="50">0.10 × 10<sup>2</sup></td></tr><tr><td align="left" valign="top" charoff="50">ERM-AD623f</td><td align="center" valign="top" charoff="50">10.0</td><td align="center" valign="top" charoff="50">4.28</td><td align="center" valign="top" charoff="50">4.37</td><td align="center" valign="top" charoff="50">3.83</td><td align="center" valign="top" charoff="50">14.42</td><td align="center" valign="top" charoff="50">1.5</td></tr></tbody></table><table-wrap-foot><fn id="t1-fn1"><p>Abbreviations: CRM, certified reference material; <italic>u</italic><sub>bb,rel</sub>, relative uncertainity related to potential between-unit heterogeneity of the material; <italic>u</italic><sub>char,rel</sub>, relative uncertainity related to the charecterisation study; <italic>u</italic><sub>CRM</sub>, expanded uncertainity of the certified value (with <italic>k</italic>=2); <italic>u</italic><sub>CRM,rel</sub>, relative expanded uncertainity of the certified value (with <italic>k</italic>=2); <italic>u</italic><sub>lts,rel</sub>, relative uncertainity related to potential degradation during long-term storage (24 months at −20 °C).</p></fn><fn id="t1-fn2"><label>a</label><p>As the copy number concentrations refer to the copy numbers of double-stranded plasmid, these numbers should be doubled when calibrating quantitative real-time PCR experiments that measure single-stranded cDNA samples.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tbl2"><label>Table 2</label><caption><title>Comparison of results for the cell line dilutions using local calibrators (Lab) and ERM-AD623</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="char"></col><col align="char"></col><col align="char"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><italic>Cell line dilution</italic></th><th align="center" valign="top" charoff="50"><italic>Standard curve</italic></th><th align="center" valign="top" charoff="50"><italic>Median value (% BCR–ABL1/CG)</italic></th><th align="center" valign="top" charoff="50"><italic>% Labs within twofold</italic></th><th align="center" valign="top" charoff="50"><italic>% Labs within fivefold</italic></th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">Level 1</td><td align="center" valign="top" charoff="50">Lab</td><td align="center" valign="top" charoff="50">5.732</td><td align="center" valign="top" charoff="50">80.8</td><td align="center" valign="top" charoff="50">100</td></tr><tr><td align="left" valign="top" charoff="50">Level 2</td><td align="center" valign="top" charoff="50">Lab</td><td align="center" valign="top" charoff="50">0.043</td><td align="center" valign="top" charoff="50">75.0</td><td align="center" valign="top" charoff="50">96.1</td></tr><tr><td align="left" valign="top" charoff="50">Level 3</td><td align="center" valign="top" charoff="50">Lab</td><td align="center" valign="top" charoff="50">0.004</td><td align="center" valign="top" charoff="50">67.3</td><td align="center" valign="top" charoff="50">86.5</td></tr><tr><td align="left" valign="top" charoff="50">Level 1</td><td align="center" valign="top" charoff="50">ERM-AD623</td><td align="center" valign="top" charoff="50">4.636</td><td align="center" valign="top" charoff="50">92.3</td><td align="center" valign="top" charoff="50">100</td></tr><tr><td align="left" valign="top" charoff="50">Level 2</td><td align="center" valign="top" charoff="50">ERM-AD623</td><td align="center" valign="top" charoff="50">0.034</td><td align="center" valign="top" charoff="50">86.5</td><td align="center" valign="top" charoff="50">96.1</td></tr><tr><td align="left" valign="top" charoff="50">Level 3</td><td align="center" valign="top" charoff="50">ERM-AD623</td><td align="center" valign="top" charoff="50">0.003</td><td align="center" valign="top" charoff="50">80.8</td><td align="center" valign="top" charoff="50">94.2</td></tr></tbody></table></table-wrap><table-wrap id="tbl3"><label>Table 3</label><caption><title>Comparison of results for the aRNA mixtures using local calibrators (Lab) and ERM-AD623</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="char"></col><col align="char"></col><col align="char"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><italic>aRNA mixture</italic></th><th align="center" valign="top" charoff="50"><italic>Standard curve</italic></th><th align="center" valign="top" charoff="50"><italic>Predicted value (% BCR–ABL1/CG)</italic></th><th align="center" valign="top" charoff="50"><italic>% Labs within twofold</italic></th><th align="center" valign="top" charoff="50"><italic>% Labs within fivefold</italic></th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">Level 1</td><td align="center" valign="top" charoff="50">Lab</td><td align="center" valign="top" charoff="50">0.1</td><td align="center" valign="top" charoff="50">72</td><td align="center" valign="top" charoff="50">92</td></tr><tr><td align="left" valign="top" charoff="50">Level 2</td><td align="center" valign="top" charoff="50">Lab</td><td align="center" valign="top" charoff="50">0.01</td><td align="center" valign="top" charoff="50">64</td><td align="center" valign="top" charoff="50">94</td></tr><tr><td align="left" valign="top" charoff="50">Level 1</td><td align="center" valign="top" charoff="50">ERM-AD623</td><td align="center" valign="top" charoff="50">0.1</td><td align="center" valign="top" charoff="50">80</td><td align="center" valign="top" charoff="50">94</td></tr><tr><td align="left" valign="top" charoff="50">Level 2</td><td align="center" valign="top" charoff="50">ERM-AD623</td><td align="center" valign="top" charoff="50">0.01</td><td align="center" valign="top" charoff="50">72</td><td align="center" valign="top" charoff="50">92</td></tr></tbody></table></table-wrap></floats-group></pmc><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Corée du Sud</li><li>Croatie</li><li>Danemark</li><li>Espagne</li><li>Estonie</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Hongrie</li><li>Irlande (pays)</li><li>Israël</li><li>Italie</li><li>Lituanie</li><li>Norvège</li><li>Pays-Bas</li><li>Pologne</li><li>Roumanie</li><li>Royaume-Uni</li><li>République tchèque</li><li>Slovénie</li><li>Suisse</li><li>Suède</li><li>Turquie</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Attique (région)</li><li>Bade-Wurtemberg</li><li>Bohême centrale</li><li>Canton de Berne</li><li>Catalogne</li><li>District de Darmstadt</li><li>District de Karlsruhe</li><li>District de Leipzig</li><li>East Middle Sweden</li><li>Finlande occidentale</li><li>Grand Londres</li><li>Hauts-de-France</li><li>Hesse (Land)</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Moravie</li><li>Nord-Pas-de-Calais</li><li>Nouvelle-Aquitaine</li><li>Piémont</li><li>Région capitale de Séoul</li><li>Région de Bruxelles-Capitale</li><li>Saxe (Land)</li><li>Svealand</li><li>Vienne (Autriche)</li><li>Østlandet</li></region><settlement><li>Amsterdam</li><li>Athènes</li><li>Barcelone</li><li>Berne</li><li>Bordeaux</li><li>Brno</li><li>Bruxelles</li><li>Francfort-sur-le-Main</li><li>Leipzig</li><li>Lille</li><li>Londres</li><li>Mannheim</li><li>Oslo</li><li>Prague</li><li>Rotterdam</li><li>Séoul</li><li>Turin</li><li>Turku</li><li>Uppsala</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université d'Uppsala</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="White, H" sort="White, H" uniqKey="White H" first="H" last="White">H. White</name></noRegion><name sortKey="Akiki, S" sort="Akiki, S" uniqKey="Akiki S" first="S" last="Akiki">S. Akiki</name><name sortKey="Bench, A" sort="Bench, A" uniqKey="Bench A" first="A" last="Bench">A. Bench</name><name sortKey="Catherwood, M" sort="Catherwood, M" uniqKey="Catherwood M" first="M" last="Catherwood">M. Catherwood</name><name sortKey="Chudleigh, S" sort="Chudleigh, S" uniqKey="Chudleigh S" first="S" last="Chudleigh">S. Chudleigh</name><name sortKey="Clench, T" sort="Clench, T" uniqKey="Clench T" first="T" last="Clench">T. Clench</name><name sortKey="Cross, N C P" sort="Cross, N C P" uniqKey="Cross N" first="N C P" last="Cross">N C P. Cross</name><name sortKey="Cross, N C P" sort="Cross, N C P" uniqKey="Cross N" first="N C P" last="Cross">N C P. Cross</name><name sortKey="Farrugia, J" sort="Farrugia, J" uniqKey="Farrugia J" first="J" last="Farrugia">J. Farrugia</name><name sortKey="Foroni, L" sort="Foroni, L" uniqKey="Foroni L" first="L" last="Foroni">L. Foroni</name><name sortKey="Ganderton, R" sort="Ganderton, R" uniqKey="Ganderton R" first="R" last="Ganderton">R. Ganderton</name><name sortKey="Gerrard, G" sort="Gerrard, G" uniqKey="Gerrard G" first="G" last="Gerrard">G. Gerrard</name><name sortKey="Hall, V" sort="Hall, V" uniqKey="Hall V" first="V" last="Hall">V. Hall</name><name sortKey="Kizilors, A" sort="Kizilors, A" uniqKey="Kizilors A" first="A" last="Kizilors">A. Kizilors</name><name sortKey="Lin, F" sort="Lin, F" uniqKey="Lin F" first="F" last="Lin">F. Lin</name><name sortKey="Lin, F" sort="Lin, F" uniqKey="Lin F" first="F" last="Lin">F. Lin</name><name sortKey="Milner, B" sort="Milner, B" uniqKey="Milner B" first="B" last="Milner">B. Milner</name><name sortKey="Nickless, G" sort="Nickless, G" uniqKey="Nickless G" first="G" last="Nickless">G. Nickless</name><name sortKey="Waits, P" sort="Waits, P" uniqKey="Waits P" first="P" last="Waits">P. Waits</name><name sortKey="Wang, L" sort="Wang, L" uniqKey="Wang L" first="L" last="Wang">L. Wang</name><name sortKey="White, H" sort="White, H" uniqKey="White H" first="H" last="White">H. White</name><name sortKey="Wilkinson, E" sort="Wilkinson, E" uniqKey="Wilkinson E" first="E" last="Wilkinson">E. Wilkinson</name><name sortKey="Wilson, G" sort="Wilson, G" uniqKey="Wilson G" first="G" last="Wilson">G. Wilson</name><name sortKey="Wren, D" sort="Wren, D" uniqKey="Wren D" first="D" last="Wren">D. Wren</name></country><country name="Belgique"><noRegion><name sortKey="Deprez, L" sort="Deprez, L" uniqKey="Deprez L" first="L" last="Deprez">L. Deprez</name></noRegion><name sortKey="Boeckx, N" sort="Boeckx, N" uniqKey="Boeckx N" first="N" last="Boeckx">N. Boeckx</name><name sortKey="Boeckx, N" sort="Boeckx, N" uniqKey="Boeckx N" first="N" last="Boeckx">N. Boeckx</name><name sortKey="Corbisier, P" sort="Corbisier, P" uniqKey="Corbisier P" first="P" last="Corbisier">P. Corbisier</name><name sortKey="El Housni, H" sort="El Housni, H" uniqKey="El Housni H" first="H" last="El Housni">H. El Housni</name><name sortKey="Emons, H" sort="Emons, H" uniqKey="Emons H" first="H" last="Emons">H. Emons</name><name sortKey="Mazoua, S" sort="Mazoua, S" uniqKey="Mazoua S" first="S" last="Mazoua">S. Mazoua</name><name sortKey="Schimmel, H" sort="Schimmel, H" uniqKey="Schimmel H" first="H" last="Schimmel">H. Schimmel</name><name sortKey="Trapmann, S" sort="Trapmann, S" uniqKey="Trapmann S" first="S" last="Trapmann">S. Trapmann</name></country><country name="Danemark"><noRegion><name sortKey="Aggerholm, A" sort="Aggerholm, A" uniqKey="Aggerholm A" first="A" last="Aggerholm">A. Aggerholm</name></noRegion></country><country name="Hongrie"><noRegion><name sortKey="Andrikovics, H" sort="Andrikovics, H" uniqKey="Andrikovics H" first="H" last="Andrikovics">H. Andrikovics</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Barbany, G" sort="Barbany, G" uniqKey="Barbany G" first="G" last="Barbany">G. Barbany</name></noRegion><name sortKey="Jansson, M" sort="Jansson, M" uniqKey="Jansson M" first="M" last="Jansson">M. Jansson</name><name sortKey="Johnels, P" sort="Johnels, P" uniqKey="Johnels P" first="P" last="Johnels">P. Johnels</name></country><country name="France"><noRegion><name sortKey="Cayuela, J M" sort="Cayuela, J M" uniqKey="Cayuela J" first="J-M" last="Cayuela">J-M Cayuela</name></noRegion><name sortKey="Dulucq, S" sort="Dulucq, S" uniqKey="Dulucq S" first="S" last="Dulucq">S. Dulucq</name><name sortKey="Hayette, S" sort="Hayette, S" uniqKey="Hayette S" first="S" last="Hayette">S. Hayette</name><name sortKey="Preudhomme, C" sort="Preudhomme, C" uniqKey="Preudhomme C" first="C" last="Preudhomme">C. Preudhomme</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Colomer, D" sort="Colomer, D" uniqKey="Colomer D" first="D" last="Colomer">D. Colomer</name></region><name sortKey="Nomdedeu, J" sort="Nomdedeu, J" uniqKey="Nomdedeu J" first="J" last="Nomdedéu">J. Nomdedéu</name></country><country name="Italie"><region name="Piémont"><name sortKey="Daraio, F" sort="Daraio, F" uniqKey="Daraio F" first="F" last="Daraio">F. Daraio</name></region><name sortKey="Izzo, B" sort="Izzo, B" uniqKey="Izzo B" first="B" last="Izzo">B. Izzo</name><name sortKey="Martinelli, G" sort="Martinelli, G" uniqKey="Martinelli G" first="G" last="Martinelli">G. Martinelli</name></country><country name="Australie"><noRegion><name sortKey="Fletcher, L" sort="Fletcher, L" uniqKey="Fletcher L" first="L" last="Fletcher">L. Fletcher</name></noRegion><name sortKey="Romeo, G" sort="Romeo, G" uniqKey="Romeo G" first="G" last="Romeo">G. Romeo</name></country><country name="Lituanie"><noRegion><name sortKey="Gineikien, E" sort="Gineikien, E" uniqKey="Gineikien E" first="E" last="Gineikien">E. Gineikien</name></noRegion></country><country name="République tchèque"><region name="Moravie"><name sortKey="Jurcek, T" sort="Jurcek, T" uniqKey="Jurcek T" first="T" last="Jurcek">T. Jurcek</name></region><name sortKey="Polakova, K M" sort="Polakova, K M" uniqKey="Polakova K" first="K M" last="Polakova">K M Polakova</name></country><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Kairisto, V" sort="Kairisto, V" uniqKey="Kairisto V" first="V" last="Kairisto">V. Kairisto</name></region></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, D W" sort="Kim, D W" uniqKey="Kim D" first="D-W" last="Kim">D-W Kim</name></region></country><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Lange, T" sort="Lange, T" uniqKey="Lange T" first="T" last="Lange">T. Lange</name></region><name sortKey="Hochhaus, A" sort="Hochhaus, A" uniqKey="Hochhaus A" first="A" last="Hochhaus">A. Hochhaus</name><name sortKey="Muller, M C" sort="Muller, M C" uniqKey="Muller M" first="M C" last="Müller">M C Müller</name><name sortKey="Pfeifer, H" sort="Pfeifer, H" uniqKey="Pfeifer H" first="H" last="Pfeifer">H. Pfeifer</name><name sortKey="Ziermann, J" sort="Ziermann, J" uniqKey="Ziermann J" first="J" last="Ziermann">J. Ziermann</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Lion, T" sort="Lion, T" uniqKey="Lion T" first="T" last="Lion">T. Lion</name></region><name sortKey="Mitterbauer Hohendanner, G" sort="Mitterbauer Hohendanner, G" uniqKey="Mitterbauer Hohendanner G" first="G" last="Mitterbauer-Hohendanner">G. Mitterbauer-Hohendanner</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Mccarron, S" sort="Mccarron, S" uniqKey="Mccarron S" first="S" last="Mccarron">S. Mccarron</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Merle, P A" sort="Merle, P A" uniqKey="Merle P" first="P A" last="Merle">P A Merle</name></region><name sortKey="Van Der Velden, V H J" sort="Van Der Velden, V H J" uniqKey="Van Der Velden V" first="V H J" last="Van Der Velden">V H J. Van Der Velden</name></country><country name="Israël"><noRegion><name sortKey="Nagar, M" sort="Nagar, M" uniqKey="Nagar M" first="M" last="Nagar">M. Nagar</name></noRegion></country><country name="Norvège"><region name="Østlandet"><name sortKey="Nymoen, D A" sort="Nymoen, D A" uniqKey="Nymoen D" first="D A" last="Nymoen">D A Nymoen</name></region></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Leibundgut, E O" sort="Leibundgut, E O" uniqKey="Leibundgut E" first="E O" last="Leibundgut">E O Leibundgut</name></region></country><country name="Turquie"><noRegion><name sortKey="Ozbek, U" sort="Ozbek, U" uniqKey="Ozbek U" first="U" last="Ozbek">U. Ozbek</name></noRegion></country><country name="Slovénie"><noRegion><name sortKey="Paji, T" sort="Paji, T" uniqKey="Paji T" first="T" last="Paji">T. Paji</name></noRegion></country><country name="Estonie"><noRegion><name sortKey="Raudsepp, K" sort="Raudsepp, K" uniqKey="Raudsepp K" first="K" last="Raudsepp">K. Raudsepp</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Sacha, T" sort="Sacha, T" uniqKey="Sacha T" first="T" last="Sacha">T. Sacha</name></noRegion></country><country name="Roumanie"><noRegion><name sortKey="Talmaci, R" sort="Talmaci, R" uniqKey="Talmaci R" first="R" last="Talmaci">R. Talmaci</name></noRegion></country><country name="Grèce"><noRegion><name sortKey="Touloumenidou, T" sort="Touloumenidou, T" uniqKey="Touloumenidou T" first="T" last="Touloumenidou">T. Touloumenidou</name></noRegion><name sortKey="Zoi, K" sort="Zoi, K" uniqKey="Zoi K" first="K" last="Zoi">K. Zoi</name></country><country name="Croatie"><noRegion><name sortKey="Zadro, R" sort="Zadro, R" uniqKey="Zadro R" first="R" last="Zadro">R. Zadro</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:4320294
|texte= A certified plasmid reference material for the standardisation of BCR–ABL1 mRNA quantification by real-time quantitative PCR
}}
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| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
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