Does Stress within a Muscle Change in Response to an Acute Noxious Stimulus?
Identifieur interne : 001636 ( Pmc/Checkpoint ); précédent : 001635; suivant : 001637Does Stress within a Muscle Change in Response to an Acute Noxious Stimulus?
Auteurs : Kylie Tucker [Australie] ; Paul W. Hodges [Australie] ; Wolbert Van Den Hoorn [Australie] ; Antoine Nordez [France] ; François Hug [Australie, France]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Altered muscle activation during pain is thought to redistribute stress within muscles and ultimately decrease the load on painful structures. However, change in muscle stress during pain has not been directly tested. The aim of the present study is to determine whether stress within muscle tissue is reduced during local acute experimental pain.
Ten participants attended 2 experimental sessions that each involved isometric knee extension tasks in 2 series of control trials and 1 series of test trials at ∼10%MVC. Shear elastic modulus was measured from vastus lateralis using a shear wave elastographic technique (Supersonic Shear Imaging). Prior to the test contractions, a bolus of hypertonic (Pain) or isotonic saline (No-pain) was injected into vastus lateralis. Pain intensity was 5.2±1.0 during the painful contractions. The intra-session repeatability of the shear elastic modulus determined between control trials was good (ICC: 0.95 and 0.99; SEM: 5.1 and 9.3 kPa for No-pain and Pain, respectively). Muscle shear elastic modulus did not change systematically during Pain or No-pain contractions (all main effects and interaction P>0.14). Examination of data for individual participants showed that stress either increased or decreased. If the absolute change in modulus is considered between the control and the test trials, the change during Pain (16.2±9.5 kPa) was double that observed with No pain (7.9±5.9 kPa; P = 0.046).
This is the first study to directly determine the change in stress within a muscle (change in shear elastic modulus) during pain. We conclude that experimental pain induced by hypertonic saline does not induce a systematic reduction in muscle stress during a single-joint isometric task. Therefore, the changes in muscle activity reported previously during similar tasks are unlikely to systematically reduce load in the painful region. Whether the individual-specific increase and decrease are physiologically relevant or purposeful requires further investigation.
Url:
DOI: 10.1371/journal.pone.0091899
PubMed: 24626150
PubMed Central: 3953640
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Hodges</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>School of Health and Rehabilitation Sciences, National Health and Medical Research Council (NHMRC) Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, The University of Queensland, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Health and Rehabilitation Sciences, National Health and Medical Research Council (NHMRC) Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, The University of Queensland, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Hoorn, Wolbert" sort="Van Den Hoorn, Wolbert" uniqKey="Van Den Hoorn W" first="Wolbert" last="Van Den Hoorn">Wolbert Van Den Hoorn</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>School of Health and Rehabilitation Sciences, National Health and Medical Research Council (NHMRC) Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, The University of Queensland, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Health and Rehabilitation Sciences, National Health and Medical Research Council (NHMRC) Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, The University of Queensland, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Nordez, Antoine" sort="Nordez, Antoine" uniqKey="Nordez A" first="Antoine" last="Nordez">Antoine Nordez</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>University of Nantes, Laboratory “Motricité, Interactions, Performance” (EA 4334), Nantes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Nantes, Laboratory “Motricité, Interactions, Performance” (EA 4334), 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xml:lang="fr">Australie</country><wicri:regionArea>School of Health and Rehabilitation Sciences, National Health and Medical Research Council (NHMRC) Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, The University of Queensland, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Hodges, Paul W" sort="Hodges, Paul W" uniqKey="Hodges P" first="Paul W." last="Hodges">Paul W. Hodges</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>School of Health and Rehabilitation Sciences, National Health and Medical Research Council (NHMRC) Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, The University of Queensland, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Health and Rehabilitation Sciences, National Health and Medical Research Council (NHMRC) Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, The University of Queensland, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Hoorn, Wolbert" sort="Van Den Hoorn, Wolbert" uniqKey="Van Den Hoorn W" first="Wolbert" last="Van Den Hoorn">Wolbert Van Den Hoorn</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>School of Health and Rehabilitation Sciences, National Health and Medical Research Council (NHMRC) Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, The University of Queensland, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Health and Rehabilitation Sciences, National Health and Medical Research Council (NHMRC) Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, The University of Queensland, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Nordez, Antoine" sort="Nordez, Antoine" uniqKey="Nordez A" first="Antoine" last="Nordez">Antoine Nordez</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>University of Nantes, Laboratory “Motricité, Interactions, Performance” (EA 4334), Nantes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Nantes, Laboratory “Motricité, Interactions, Performance” (EA 4334), Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Hug, Francois" sort="Hug, Francois" uniqKey="Hug F" first="François" last="Hug">François Hug</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>School of Health and Rehabilitation Sciences, National Health and Medical Research Council (NHMRC) Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, The University of Queensland, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Health and Rehabilitation Sciences, National Health and Medical Research Council (NHMRC) Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, The University of Queensland, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>University of Nantes, Laboratory “Motricité, Interactions, Performance” (EA 4334), Nantes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Nantes, Laboratory “Motricité, Interactions, Performance” (EA 4334), Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Altered muscle activation during pain is thought to redistribute stress within muscles and ultimately decrease the load on painful structures. However, change in muscle stress during pain has not been directly tested. The aim of the present study is to determine whether stress within muscle tissue is reduced during local acute experimental pain.</p></sec><sec><title>Methods and Results</title><p>Ten participants attended 2 experimental sessions that each involved isometric knee extension tasks in 2 series of control trials and 1 series of test trials at ∼10%MVC. Shear elastic modulus was measured from vastus lateralis using a shear wave elastographic technique (Supersonic Shear Imaging). Prior to the test contractions, a bolus of hypertonic (Pain) or isotonic saline (No-pain) was injected into vastus lateralis. Pain intensity was 5.2±1.0 during the painful contractions. The intra-session repeatability of the shear elastic modulus determined between control trials was good (ICC: 0.95 and 0.99; SEM: 5.1 and 9.3 kPa for No-pain and Pain, respectively). Muscle shear elastic modulus did not change systematically during Pain or No-pain contractions (all main effects and interaction P>0.14). Examination of data for individual participants showed that stress either increased or decreased. If the absolute change in modulus is considered between the control and the test trials, the change during Pain (16.2±9.5 kPa) was double that observed with No pain (7.9±5.9 kPa; P = 0.046).</p></sec><sec><title>Conclusion</title><p>This is the first study to directly determine the change in stress within a muscle (change in shear elastic modulus) during pain. We conclude that experimental pain induced by hypertonic saline does not induce a systematic reduction in muscle stress during a single-joint isometric task. Therefore, the changes in muscle activity reported previously during similar tasks are unlikely to systematically reduce load in the painful region. Whether the individual-specific increase and decrease are physiologically relevant or purposeful requires further investigation.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hirata, Rp" uniqKey="Hirata R">RP Hirata</name></author><author><name sortKey="Arendt Nielsen, L" uniqKey="Arendt Nielsen L">L Arendt-Nielsen</name></author><author><name sortKey="Graven Nielsen, T" uniqKey="Graven Nielsen T">T Graven-Nielsen</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Falla, D" uniqKey="Falla D">D Falla</name></author><author><name sortKey="Arendt Nielsen, L" uniqKey="Arendt Nielsen L">L Arendt-Nielsen</name></author><author><name sortKey="Farina, D" uniqKey="Farina D">D Farina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madeleine, P" uniqKey="Madeleine P">P Madeleine</name></author><author><name sortKey="Leclerc, F" 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uniqKey="Hodges P">PW Hodges</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Svensson, P" uniqKey="Svensson P">P Svensson</name></author><author><name sortKey="Arendt Nielsen, L" uniqKey="Arendt Nielsen L">L Arendt-Nielsen</name></author><author><name sortKey="Houe, L" uniqKey="Houe L">L Houe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farina, D" uniqKey="Farina D">D Farina</name></author><author><name sortKey="Merletti, R" uniqKey="Merletti R">R Merletti</name></author><author><name sortKey="Enoka, Rm" uniqKey="Enoka R">RM Enoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hug, F" uniqKey="Hug F">F Hug</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, M" uniqKey="Smith M">M Smith</name></author><author><name sortKey="Coppieters, Mw" uniqKey="Coppieters M">MW Coppieters</name></author><author><name sortKey="Hodges, Pw" uniqKey="Hodges P">PW Hodges</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24626150</article-id><article-id pub-id-type="pmc">3953640</article-id><article-id pub-id-type="publisher-id">PONE-D-13-35951</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0091899</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology</subject><subj-group><subject>Anatomy and Physiology</subject><subj-group><subject>Musculoskeletal System</subject><subj-group><subject>Biomechanics</subject><subj-group><subject>Tissue Mechanics</subject></subj-group></subj-group></subj-group></subj-group><subj-group><subject>Molecular Cell Biology</subject><subj-group><subject>Cellular Stress Responses</subject></subj-group></subj-group><subj-group><subject>Neuroscience</subject><subj-group><subject>Cognitive Neuroscience</subject><subj-group><subject>Pain</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject><subj-group><subject>Anatomy and Physiology</subject><subj-group><subject>Musculoskeletal System</subject><subj-group><subject>Muscle</subject></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Does Stress within a Muscle Change in Response to an Acute Noxious Stimulus?</article-title><alt-title alt-title-type="running-head">Altered Muscle Stress with Acute Pain</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tucker</surname><given-names>Kylie</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hodges</surname><given-names>Paul W.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Van den Hoorn</surname><given-names>Wolbert</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nordez</surname><given-names>Antoine</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hug</surname><given-names>François</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>School of Health and Rehabilitation Sciences, National Health and Medical Research Council (NHMRC) Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, The University of Queensland, Brisbane, Queensland, Australia</addr-line></aff><aff id="aff2"><label>2</label><addr-line>School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia</addr-line></aff><aff id="aff3"><label>3</label><addr-line>University of Nantes, Laboratory “Motricité, Interactions, Performance” (EA 4334), Nantes, France</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Kellermayer</surname><given-names>Miklos S.</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Semmelweis University, Hungary</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>f.hug@uq.edu.au</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>Co-author François HUG is a PLOS ONE Editorial Board member. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: KT PWH WVdDH AN FH. Performed the experiments: KT WVdH FH. Analyzed the data: KT WVdH FH. Contributed reagents/materials/analysis tools: KT WVdH FH. Wrote the paper: KT PWH WVdH AN FH.</p></fn></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>13</day><month>3</month><year>2014</year></pub-date><volume>9</volume><issue>3</issue><elocation-id>e91899</elocation-id><history><date date-type="received"><day>2</day><month>9</month><year>2013</year></date><date date-type="accepted"><day>11</day><month>2</month><year>2014</year></date></history><permissions><copyright-year>2014</copyright-year><copyright-holder>Tucker et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><sec><title>Background</title><p>Altered muscle activation during pain is thought to redistribute stress within muscles and ultimately decrease the load on painful structures. However, change in muscle stress during pain has not been directly tested. The aim of the present study is to determine whether stress within muscle tissue is reduced during local acute experimental pain.</p></sec><sec><title>Methods and Results</title><p>Ten participants attended 2 experimental sessions that each involved isometric knee extension tasks in 2 series of control trials and 1 series of test trials at ∼10%MVC. Shear elastic modulus was measured from vastus lateralis using a shear wave elastographic technique (Supersonic Shear Imaging). Prior to the test contractions, a bolus of hypertonic (Pain) or isotonic saline (No-pain) was injected into vastus lateralis. Pain intensity was 5.2±1.0 during the painful contractions. The intra-session repeatability of the shear elastic modulus determined between control trials was good (ICC: 0.95 and 0.99; SEM: 5.1 and 9.3 kPa for No-pain and Pain, respectively). Muscle shear elastic modulus did not change systematically during Pain or No-pain contractions (all main effects and interaction P>0.14). Examination of data for individual participants showed that stress either increased or decreased. If the absolute change in modulus is considered between the control and the test trials, the change during Pain (16.2±9.5 kPa) was double that observed with No pain (7.9±5.9 kPa; P = 0.046).</p></sec><sec><title>Conclusion</title><p>This is the first study to directly determine the change in stress within a muscle (change in shear elastic modulus) during pain. We conclude that experimental pain induced by hypertonic saline does not induce a systematic reduction in muscle stress during a single-joint isometric task. Therefore, the changes in muscle activity reported previously during similar tasks are unlikely to systematically reduce load in the painful region. Whether the individual-specific increase and decrease are physiologically relevant or purposeful requires further investigation.</p></sec></abstract><funding-group><funding-statement>National Health and Medical Research Council provided research fellowships for PH: ID401599 and KT: ID1009410. Financial support for KT was also provided by a Queensland Government Research Travel Fellowship, 2012; Project support was provided by a grant from the European Regional Development Fund (FH and AN, FEDER No 37400), and NHMRC Program grant (PH: ID631717). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="7"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Pays de la Loire</li></region><settlement><li>Nantes</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Tucker, Kylie" sort="Tucker, Kylie" uniqKey="Tucker K" first="Kylie" last="Tucker">Kylie Tucker</name></noRegion><name sortKey="Hodges, Paul W" sort="Hodges, Paul W" uniqKey="Hodges P" first="Paul W." last="Hodges">Paul W. Hodges</name><name sortKey="Hug, Francois" sort="Hug, Francois" uniqKey="Hug F" first="François" last="Hug">François Hug</name><name sortKey="Tucker, Kylie" sort="Tucker, Kylie" uniqKey="Tucker K" first="Kylie" last="Tucker">Kylie Tucker</name><name sortKey="Van Den Hoorn, Wolbert" sort="Van Den Hoorn, Wolbert" uniqKey="Van Den Hoorn W" first="Wolbert" last="Van Den Hoorn">Wolbert Van Den Hoorn</name></country><country name="France"><region name="Pays de la Loire"><name sortKey="Nordez, Antoine" sort="Nordez, Antoine" uniqKey="Nordez A" first="Antoine" last="Nordez">Antoine Nordez</name></region><name sortKey="Hug, Francois" sort="Hug, Francois" uniqKey="Hug F" first="François" last="Hug">François Hug</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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